Hub : Genes

TP53INP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0330	0.0170	1.3e-02	0.051	0.006	0.047	0.012	0.043	8.0e-07	5.3e-02	2.2e-06	1.2e-02	4.7e-06
2	GTEx	Artery Aorta	0.0810	0.0370	8.7e-03	0.017	NA	0.029	NA	0.021	3.9e-02	NA	9.7e-03	NA	2.5e-02
3	GTEx	Skin Sun Exposed Lower leg	0.0950	0.0290	1.1e-05	0.056	NA	0.067	NA	0.011	1.9e-05	NA	3.3e-06	NA	3.7e-02
4	GTEx	Testis	0.1210	0.0470	1.5e-03	0.098	NA	0.042	NA	0.000	4.1e-05	NA	6.1e-03	NA	3.1e-01
5	GTEx	Whole Blood	0.0730	0.0260	4.1e-04	0.041	NA	0.023	NA	0.000	1.1e-04	NA	2.9e-03	NA	3.5e-01
6	YFS	Blood	0.0273	0.0085	5.5e-07	0.018	0.015	0.018	0.015	0.018	1.4e-06	8.1e-06	8.6e-07	5.5e-06	8.0e-07
7	TCGA	Head and Neck Squamous Cell Carcinoma	0.0440	0.0201	3.2e-06	0.054	0.058	0.057	NA	0.054	1.1e-06	4.2e-07	5.5e-07	NA	1.0e-06
8	TCGA	Prostate Adenocarcinoma	0.0365	0.0220	7.0e-03	0.003	0.015	0.003	NA	0.007	1.6e-01	8.5e-03	1.4e-01	NA	5.1e-02
9	TCGA	Stomach Adenocarcinoma	0.0570	0.0360	2.0e-03	0.024	0.029	0.024	NA	0.030	7.1e-03	3.5e-03	7.5e-03	NA	2.8e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	0.7	1.1	4.1	1.1	-0.9	0.4	0.5	-0.7	-0.5	-1.2	-2.0	-1.0
Bipolar Disorder or Schizophrenia	0.7	1.6	7.0	2.1	-1.0	-0.3	0.2	-0.4	-0.5	-1.2	-2.6	-0.7
Depressed Affect (Nagel 2018)	0.6	1.3	2.9	-0.4	0.7	-1.6	-1.0	1.4	1.2	0.9	-0.4	1.7
Depression (Nagel 2018)	0.3	0.5	1.2	-0.0	-0.1	-1.1	-0.8	0.7	0.6	0.6	-0.6	0.8
Intelligence (Savage-Jansen 2018)	0.6	1.9	4.6	-0.1	-0.0	1.7	1.8	-1.6	-2.2	-1.3	-0.0	-1.5
Neuroticism (Nagel 2018)	0.2	0.4	1.0	-0.6	0.5	-0.6	-0.1	0.6	0.8	0.6	0.2	1.0
Schizophrenia (2018)	0.4	0.8	3.1	1.7	-0.6	-0.7	-0.1	0.1	-0.2	-0.5	-1.8	-0.1
Schizophrenia vs Biploar Disorder	0.9	1.2	3.7	1.9	0.9	-1.3	-1.3	0.6	0.1	1.2	0.1	1.0
Worry (Nagel 2018)	0.2	0.4	2.3	-0.7	1.5	-0.1	0.5	-0.0	0.1	0.2	0.6	0.4
Alzheimer’s Disease (in mother)	0.7	0.9	1.9	-1.4	-0.0	0.9	1.1	-1.4	-0.8	-0.6	0.6	-0.8
Alzheimer’s Disease (in father)	2.9	3.2	6.4	-2.5	-0.8	2.1	2.3	-2.0	-0.8	-1.7	1.0	-2.0
Alzheimer’s Disease (including proxy)	8.2	11.9	21.8	-3.1	-2.5	3.8	3.8	-4.4	-2.8	-3.7	-0.5	-4.7
Crohns Disease (2017)	0.2	0.4	2.4	-0.7	-1.6	-0.0	0.1	0.5	-0.1	-0.5	-0.1	0.5
Irritable Bowel Disease (IBD)	0.2	0.4	1.5	-1.2	-1.0	-0.2	0.2	0.5	0.1	-0.5	-0.1	0.4
Ulcerative Colitis (UC)	0.1	0.3	1.1	-1.0	-0.2	-0.2	0.3	0.1	-0.1	-0.8	-0.7	-0.2
Major Depression (MDD)	0.1	0.2	0.5	-0.1	-0.6	-0.1	0.3	0.2	-0.7	-0.1	-0.6	-0.1
Reaction Time	1.1	2.0	3.4	1.7	1.7	-1.5	-1.7	1.2	1.8	1.2	-0.1	1.1
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.2	-0.0	0.1	0.9	1.1	-0.6	-0.5	-0.6	-0.1	-0.9
Breast Cancer	0.9	2.1	10.9	-2.3	1.1	0.3	0.4	-0.1	0.6	0.7	3.3	0.4
Ovarian Cancer	0.3	0.3	1.2	-1.1	-1.0	0.4	0.2	0.5	0.7	0.1	0.2	0.1
Prostate Cancer	1.4	1.9	7.4	-2.3	1.2	-0.2	0.2	0.6	0.2	1.1	2.7	1.2
Age at First Birth	0.4	0.5	1.4	0.8	0.6	-0.5	-0.7	1.0	0.6	0.4	-1.2	0.4
Bipolar Disorder (2011)	0.2	0.2	0.8	0.9	-0.1	0.2	-0.2	0.5	0.0	0.1	-0.6	0.1
Body Mass Index (BMI) (2010)	0.7	1.0	1.9	1.4	-0.7	-1.0	-1.1	0.9	1.3	0.9	-0.2	1.1
Coronary Artery Disease (CAD)	3.3	4.0	9.8	0.2	0.8	-1.3	-1.9	1.6	1.9	3.1	2.6	2.5
Crohns Disease (2012)	0.1	0.1	0.8	0.0	-0.9	0.3	0.3	-0.1	-0.3	-0.2	0.3	0.1
Mean Putamen Volume	0.2	0.2	1.0	-0.3	1.0	0.1	0.3	0.6	-0.4	0.0	-0.2	0.2
Fasting Glucose	2.4	2.9	5.5	1.0	1.3	-2.1	-2.3	1.7	2.3	1.7	-0.2	1.4
HbA1C	0.8	0.9	1.9	-0.7	1.1	-0.8	-1.0	1.4	0.7	1.1	0.5	1.2
HDL Cholesterol	0.3	0.6	2.1	-1.4	-0.1	0.8	0.6	-0.7	-0.9	-0.3	0.4	-0.4
LDL Cholesterol	0.6	1.0	4.4	-0.4	1.2	0.2	-0.6	0.6	0.3	1.1	2.1	0.8
Lupus	0.6	0.9	4.1	0.7	-2.0	0.1	-0.1	0.1	-0.9	-0.4	-1.6	0.0
Neuroticism (2016)	0.2	0.3	0.7	0.3	-0.6	-0.0	-0.2	0.4	0.1	0.7	0.8	0.8
Primary Biliary Cirrhosis	0.3	0.5	1.7	0.3	-1.2	-0.2	0.5	-0.1	-0.6	-0.5	-1.3	-0.2
Rheumatoid Arthritis	1.6	2.1	3.6	-0.8	-1.9	1.1	1.4	-1.7	-1.2	-1.7	-1.3	-1.6
Schizophrenia (2014)	0.4	0.9	4.9	2.2	-0.4	-0.7	-0.4	0.0	-0.3	-0.3	-1.6	-0.1
Triglycerides	2.3	3.8	7.3	0.6	1.4	-2.0	-1.9	2.0	2.7	2.4	1.5	2.4
Type 2 Diabetes (T2D) (2012)	10.5	12.1	21.4	3.0	2.0	-3.7	-4.0	3.8	4.6	4.0	1.0	3.7
Ulcerative Colitis	0.6	0.8	2.4	-0.4	1.1	-0.9	-0.6	1.2	1.6	0.6	0.2	0.8
Blood Eosinophil Count	3.7	28.2	41.5	-4.5	-4.3	5.4	6.1	-6.4	-6.1	-5.8	-0.3	-6.0
Blood Platelet Count	1.0	11.9	16.6	-2.9	-3.8	3.5	3.9	-3.0	-4.0	-4.1	-1.4	-3.6
Blood Red Count	4.9	47.5	73.3	2.2	6.7	-7.5	-7.5	7.2	7.6	8.6	3.5	8.3
Blood White Count	0.3	2.3	7.4	1.4	-2.0	-1.7	-1.6	1.1	0.1	0.0	-2.7	0.8
Heel T-Score	0.3	2.7	7.6	2.4	-2.8	1.1	1.1	-1.3	-2.0	-1.2	-0.4	-1.2
BMI	0.5	2.8	10.0	-3.2	2.1	-0.2	0.0	0.2	1.2	1.3	2.7	0.5
Height	0.1	1.4	6.8	0.0	2.0	0.3	-0.5	0.6	0.5	0.8	2.6	0.2
Waist Hip Ratio (WHR)	0.0	0.2	0.9	-0.0	-0.2	-0.2	-0.2	-0.8	1.0	0.1	-0.1	-0.1
Systolic Blood Pressure	4.2	21.0	34.8	3.1	3.3	-5.0	-5.0	5.9	5.6	4.8	0.1	5.2
Smoking Status	0.3	0.7	1.2	-0.1	-0.0	-0.8	-0.9	0.6	1.0	1.1	1.1	0.8
Allergy or Eczema	0.5	1.3	5.6	2.1	-1.0	-0.2	-0.1	0.0	-0.7	-0.7	-2.4	-0.5
Cardiovascular Disease	7.2	23.7	34.6	1.8	5.2	-4.7	-4.7	5.6	5.7	5.9	2.5	5.8
Hypothyroidism (self reported)	1.1	2.6	9.8	-3.1	0.3	1.6	1.4	-1.1	-0.5	-0.1	2.6	-0.9
Respiratory disease	0.6	1.4	4.6	-2.1	-0.9	0.9	1.3	-1.1	-1.6	-0.6	0.9	-0.3
Type 2 Diabetes (T2D) (2018)	9.0	16.9	26.0	3.5	3.0	-4.5	-4.8	4.0	4.6	5.1	1.5	4.7
Lung FEV1/FVC ratio	2.4	12.4	18.2	-3.4	-2.6	3.4	4.3	-3.9	-3.5	-4.2	-0.9	-4.1
Lung FVC	0.6	2.8	10.2	0.6	-2.6	-0.5	0.9	-0.7	-1.6	-1.9	-3.2	-0.6
Neuroticism	0.2	0.5	2.5	-0.6	1.6	0.1	0.2	0.1	0.9	0.4	0.9	0.3
Chronotype (morning person)	0.2	0.5	1.4	0.7	-0.2	-0.8	-0.3	0.7	1.2	0.5	-0.3	1.0
Hair Pigment	0.1	4.0	7.1	0.1	1.6	-2.4	-1.4	2.3	2.7	2.2	1.0	2.6
Tanning	0.0	0.1	0.3	-0.3	-0.0	0.2	-0.1	-0.2	-0.1	-0.1	0.5	-0.4
Hand grip strength (left)	0.2	0.5	1.2	-0.9	0.8	-0.7	-0.3	0.4	1.1	0.8	0.7	0.5
Number of treatments/medications taken	3.3	5.9	11.8	0.5	3.4	-2.1	-2.2	2.9	1.5	2.8	1.5	3.2
Average weekly spirits intake	0.5	0.6	1.6	1.0	0.4	-0.9	-1.3	0.4	0.8	0.9	0.3	0.6
Sensitivity / hurt feelings	1.8	3.1	6.1	-1.8	-1.4	2.5	2.3	-2.0	-0.8	-1.1	1.9	-1.4
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.5	0.9	-0.7	-1.2	-1.0	0.9	0.9	0.9	-0.6	1.0
Hearing difficulty/problems: Yes	0.8	1.2	3.5	-0.7	0.2	1.8	1.2	-0.9	-1.9	-0.6	0.8	-0.8
Relative age of first facial hair	0.1	0.2	0.5	0.1	-0.6	0.6	0.7	0.0	-0.7	0.1	0.5	0.1
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	3.3	0.1	1.8	-0.6	-0.7	0.4	0.3	1.4	1.2	1.0
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.0	-0.7	1.0	-0.3	-0.8	0.2	-0.5	0.7	0.9	0.8
Ever had hysterectomy (womb removed)	0.3	0.3	1.3	-0.8	0.5	0.5	-0.2	-0.4	0.0	0.4	1.1	-0.2
Systolic blood pressure, automated reading	2.2	6.3	10.5	1.1	2.8	-2.5	-2.5	3.2	3.0	2.8	0.4	2.9
Eye problems/disorders: Diabetes related eye disease	3.6	4.0	6.6	1.6	1.3	-1.8	-2.4	2.3	2.4	2.6	0.8	1.9
Angina	3.4	4.5	8.9	0.3	1.4	-1.5	-2.3	3.0	2.7	2.6	1.5	2.2
Medication for hormone replacement therapy	0.5	0.5	1.1	0.4	0.0	-1.0	-1.1	0.8	-0.5	0.6	-0.5	1.0
Vitamin and mineral supplements	0.7	0.9	2.1	-1.2	-0.4	1.1	1.1	-1.4	-0.3	-0.3	1.2	-0.8
Supplements: Zinc	0.9	1.0	2.2	0.5	-0.3	0.5	0.6	-1.2	-0.9	-1.2	-1.5	-1.5
Medication: Co-codamol	0.9	1.0	3.9	-2.0	-0.9	1.0	0.7	-0.4	-0.6	-1.0	0.7	-1.0
Medication: Metformin	4.2	6.0	9.0	2.6	1.6	-2.8	-2.9	2.0	2.8	3.0	0.5	2.8
Diabetes (father)	1.4	1.8	3.6	1.7	0.6	-1.3	-1.9	1.1	1.9	1.4	0.0	1.0
Diabetes (mother)	4.4	5.7	10.2	1.0	2.2	-2.2	-2.8	2.8	3.2	2.9	0.4	2.4
Severe depression (siblings)	0.6	0.7	1.5	1.0	-1.2	0.7	0.3	-0.8	-0.3	-0.7	-0.8	-1.0
Pack years adult smoking proportion	0.3	0.4	1.2	-1.1	0.5	-0.7	-0.7	0.2	0.1	0.7	0.7	0.7
Impedance of leg (right)	2.4	11.8	24.8	5.0	0.7	-4.0	-3.8	4.0	3.1	2.4	-2.6	3.4
Leg fat-free mass (left)	0.8	4.0	15.3	-3.2	1.5	1.5	1.4	-1.7	-0.6	0.2	3.9	-1.0
Trunk fat percentage	0.6	2.4	7.6	-1.6	2.7	-0.7	-0.8	0.5	1.1	1.7	2.3	1.1
Hand grip strength (right)	0.4	1.0	2.6	-0.8	1.2	-0.9	-0.7	0.8	1.6	1.0	0.9	0.7
Townsend deprivation index at recruitment	0.1	0.2	0.6	0.2	0.8	-0.3	-0.4	-0.4	0.2	0.4	0.7	0.2
Current tobacco smoking	0.4	0.6	1.7	-0.8	-0.2	-0.9	-0.7	0.6	0.4	0.9	0.5	1.3
Average weekly fortified wine intake	1.8	2.1	4.0	-1.2	-0.7	2.0	1.7	-1.7	-1.6	-0.9	1.5	-1.1
Maternal smoking around birth	0.3	0.4	1.4	-0.1	-0.9	-0.1	-0.1	-0.8	0.6	0.5	1.2	0.0
Fed-up feelings	0.2	0.5	1.9	-1.4	0.2	-0.3	-0.2	0.5	1.0	0.3	0.6	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	1.5	0.8	-1.2	-1.2	-0.9	0.8	0.3	0.3	-1.0	0.7
Relative age voice broke	0.3	0.4	0.8	0.3	0.1	-0.1	-0.8	0.9	0.5	0.9	0.6	0.8
Taking other prescription medications	0.0	0.1	0.2	-0.1	0.0	-0.2	-0.4	0.1	0.1	0.2	-0.3	0.5
Age when periods started (menarche)	0.4	0.9	4.5	0.5	-2.1	-0.4	-0.0	-0.1	-0.4	-0.8	-1.6	-0.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.7	-0.2	-0.8	-0.4	-0.1	-0.1	-0.7	-0.1	-0.9	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.5	0.7	-0.5	-0.2	-0.2	0.0	-0.0	0.1	-0.1	-0.1
Tinnitus: Yes, but not now, but have in the past	2.6	2.8	5.1	1.4	1.1	-2.0	-2.2	1.6	1.1	2.3	0.2	2.0
Qualifications: CSEs or equivalent	0.4	0.5	2.3	-0.7	-0.1	0.5	-0.3	-0.1	1.0	0.0	1.5	-0.4
Serious illness, injury or assault to yourself	1.7	2.0	4.0	0.3	1.3	-1.1	-1.5	1.4	1.2	2.0	1.4	1.9
High blood pressure	5.6	15.7	23.8	1.2	4.7	-3.8	-3.4	4.4	4.4	4.9	2.3	4.8
Hayfever, allergic rhinitis or eczema	1.0	2.1	6.6	2.6	-1.4	0.2	0.3	-0.5	-1.2	-1.3	-2.5	-1.1
Multivitamins +/- minerals	1.4	1.8	6.1	1.9	0.7	-1.2	-1.1	1.7	0.3	0.0	-2.5	0.7
Stomach or abdominal pain in last month	0.7	0.8	2.1	0.4	0.6	-0.9	-0.9	1.2	-0.1	1.2	0.7	1.4
Supplements: Glucosamine	0.2	0.3	1.4	-0.1	1.2	0.4	0.4	-0.1	-0.6	-0.4	-0.7	-0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.8	-0.2	0.6	-0.9	-0.3	0.9	0.8	0.5	-0.5	0.7
Medication: Atenolol	1.6	2.1	3.9	0.9	1.0	-2.0	-1.9	1.8	1.3	1.2	0.1	1.7
Medication: Levothyroxine sodium	0.9	1.5	7.0	-2.6	0.4	0.9	0.7	-0.7	-0.1	0.1	2.0	-0.6
Sitting height	0.5	3.7	7.2	0.8	2.5	-1.4	-1.8	2.0	1.6	2.0	2.7	1.6
Chronic bronchitis/emphysema (father)	0.3	0.3	0.8	-0.9	0.7	0.5	0.2	-0.8	-0.5	-0.4	0.3	-0.4
High blood pressure (mother)	3.6	5.0	9.8	0.4	1.9	-2.4	-1.9	2.7	2.5	2.7	1.3	3.1
Body mass index (BMI)	0.9	4.0	14.8	-3.8	2.0	0.8	1.1	-1.3	0.1	0.7	3.5	-0.4
Impedance of leg (left)	3.0	14.5	29.3	5.4	0.8	-4.4	-4.4	4.5	3.4	2.7	-2.9	3.9
Leg predicted mass (left)	0.7	3.9	14.6	-3.1	1.3	1.5	1.4	-1.7	-0.6	0.1	3.8	-1.0
Trunk fat mass	0.8	3.3	10.3	-2.1	3.0	-0.5	-0.5	0.2	1.1	1.8	3.2	0.9
Waist circumference	1.2	4.3	15.6	-2.8	2.9	-0.5	-0.4	-0.1	1.7	1.9	3.9	0.9
Number of incorrect matches in round	0.9	1.5	6.5	-1.7	1.3	0.5	0.2	-0.2	0.5	1.0	2.5	0.8
Past tobacco smoking	0.6	1.0	4.8	0.5	-1.4	-0.1	0.4	-0.1	-1.0	-1.0	-2.2	0.1
Alcohol usually taken with meals	0.6	0.9	4.3	0.6	2.1	-0.4	-0.7	0.9	1.2	0.5	0.3	0.4
Nervous feelings	0.7	1.3	3.1	-1.3	-0.4	1.3	1.7	-1.3	-1.1	-0.8	0.9	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	3.0	0.5	-1.7	0.7	0.7	-1.0	-0.6	-0.9	-0.4	-0.8
Hearing difficulty/problems with background noise	0.1	0.2	0.5	0.5	0.7	0.2	-0.0	-0.0	-0.1	0.6	0.2	0.5
Hair/balding pattern: Pattern 2	0.1	0.2	1.1	-0.2	0.3	-1.0	-0.2	0.2	-0.0	0.1	-0.3	0.4
Had menopause	0.1	0.1	0.6	0.0	-0.0	-0.0	0.1	-0.4	-0.6	-0.4	-0.8	-0.3
Had other major operations	0.4	0.5	2.1	1.4	0.3	-0.6	-0.7	0.5	0.2	0.7	-0.1	0.4
Forced vital capacity (FVC)	0.2	0.6	1.8	0.5	-1.3	-0.5	0.3	0.4	-0.5	-0.8	-1.3	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.3	-0.2	-0.0	0.9	1.0	-1.2	-0.7	-0.4	0.9	-0.9
Ever unenthusiastic/disinterested for a whole week	3.5	4.3	6.2	2.5	1.6	-2.1	-2.5	2.2	1.9	2.3	0.2	2.3
Qualifications: None of the above	0.7	1.6	3.1	-1.0	-1.7	0.8	1.2	-1.7	-1.8	-1.1	-0.4	-0.8
Financial difficulties in last 2 years	0.2	0.2	0.9	-0.2	-0.0	0.6	0.4	-1.0	-0.5	-0.2	0.5	-0.4
Mouth/teeth dental problems	2.0	3.0	7.9	0.3	-2.8	1.5	1.7	-0.9	-1.9	-1.9	-1.9	-1.7
Heart attack	4.0	5.2	8.7	0.4	2.9	-1.5	-1.8	2.1	2.7	2.9	2.7	2.2
Allergy	1.5	3.4	8.7	-0.5	1.9	-1.4	-1.4	2.0	2.9	2.1	1.5	1.7
Pain all over the body in last month	0.3	0.3	1.4	0.7	0.6	-0.4	-0.3	0.3	-0.6	-0.2	-1.2	0.0
Diabetes (self-reported)	6.5	10.0	15.2	3.1	2.3	-3.5	-3.8	2.6	3.6	3.9	1.1	3.4
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	8.9	2.5	-0.1	-1.1	-0.9	0.9	-0.2	-0.9	-3.0	-0.3
Medication: Ramipril	2.1	2.7	7.1	-1.0	2.3	-0.3	-0.5	1.0	2.2	1.9	2.7	1.0
Medication: Simvastatin	2.5	3.7	6.2	1.4	2.5	-1.9	-2.1	1.9	2.2	2.0	0.7	2.0
Fluid intelligence score	0.2	0.4	0.8	-0.1	-0.6	0.7	0.9	-0.7	-0.4	-0.7	-0.5	-0.9
Illnesses of siblings	3.9	5.5	8.7	-2.2	-2.4	2.5	2.7	-2.9	-2.5	-2.2	0.3	-2.4
Neuroticism score	0.2	0.5	0.9	-0.9	-0.0	0.8	1.0	-0.7	-0.1	-0.4	0.9	-0.4
Weight	0.8	4.1	16.8	-2.9	3.0	-0.0	0.0	-0.3	0.9	1.5	4.1	0.5
Impedance of arm (right)	0.6	2.9	9.5	3.1	-0.1	-1.2	-1.8	2.1	0.7	0.4	-2.3	1.1
Arm fat percentage (right)	0.8	3.0	10.3	-3.2	2.2	0.5	0.5	-0.4	0.5	1.1	3.1	0.3
Trunk fat-free mass	0.4	2.1	11.0	-1.7	1.8	0.1	0.1	-0.3	0.8	1.1	3.3	0.3
Hip circumference	0.8	3.6	10.2	-1.9	2.8	-1.1	-0.8	0.9	1.3	2.1	3.2	1.3
Time employed in main current job	2.6	3.1	5.4	0.7	2.3	-2.0	-1.8	2.2	1.7	1.7	-0.3	1.9
Alcohol intake versus 10 years previously	0.9	1.4	3.2	-0.1	1.6	-0.7	-0.8	0.5	1.8	1.1	1.8	0.8
Father’s age at death	0.2	0.3	1.1	0.8	0.1	-0.1	-0.4	0.5	0.1	-0.4	-1.0	-0.3
Worrier / anxious feelings	0.1	0.2	0.8	-0.2	-0.2	0.5	0.9	-0.2	-0.8	-0.6	0.2	-0.2
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.8	6.9	2.4	1.2	-2.0	-2.0	2.6	2.2	1.8	-0.4	2.1
Falls in the last year	1.0	1.3	4.0	1.8	-0.8	-1.0	-0.9	1.1	0.6	0.1	-2.0	0.4
Hair/balding pattern: Pattern 3	0.6	0.9	2.1	-0.5	-0.5	1.4	0.6	-1.1	-0.9	-1.1	-0.4	-1.2
Number of live births	0.5	0.7	1.7	-0.2	0.5	-0.7	-0.3	0.5	1.1	1.2	1.3	0.7
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.5	-0.6	-1.9	0.6	1.6	-0.8	-1.4	-1.7	-0.9	-1.1
Pulse rate	0.9	1.5	3.0	-0.8	1.2	-0.7	-1.2	0.8	0.9	1.7	1.7	1.4
Happiness	1.4	1.7	3.2	0.9	-0.0	-1.8	-1.6	1.6	1.3	1.2	-0.3	1.8
Noisy workplace	0.4	0.5	1.3	-0.1	0.5	-0.8	-0.5	0.5	0.2	1.0	0.8	1.1
Qualifications: A levels/AS levels or equivalent	0.5	1.0	4.0	1.4	0.4	0.3	0.6	-0.1	-1.1	-1.0	-2.0	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.6	1.6	0.3	-0.3	-0.5	0.0	0.6	-0.2	-1.6	-0.3
Mouth/teeth dental problems: Dentures	2.4	4.0	10.0	-1.3	3.2	-1.2	-1.8	1.0	1.6	2.2	2.9	1.8
Asthma	0.5	1.0	2.0	-1.4	-0.7	1.1	0.8	-1.3	-1.4	-0.9	0.4	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.3	0.0	0.7	-0.2	-0.4	0.6	-0.8	1.0	0.9	1.1
Medication: Cholesterol lowering	2.6	4.0	5.8	1.4	1.7	-2.2	-2.4	2.3	2.2	2.2	0.4	2.3
Depression (self-reported)	0.1	0.1	0.3	-0.2	0.3	0.2	0.3	0.2	-0.4	0.1	0.6	-0.2
Medication: Lansoprazole	0.3	0.3	1.7	0.2	-1.3	-0.3	-0.2	0.6	-0.1	0.5	0.1	0.8
Prospective memory result	3.8	4.6	13.0	3.6	0.2	-2.5	-2.9	1.8	1.5	1.3	-1.9	1.7
Lung cancer (father)	2.1	2.5	6.6	-0.5	-0.9	1.9	1.6	-1.8	-2.6	-1.6	0.1	-1.8
Illnesses of mother	4.7	5.8	10.0	-1.3	-0.5	2.4	3.0	-2.7	-2.9	-3.2	-1.0	-3.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.4	4.4	-0.5	-2.1	0.6	1.3	-0.8	-1.3	-1.5	-0.6	-1.1
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	-0.2	0.6	0.5	-0.1	0.6	-0.2	0.4	0.7	0.3
Impedance of arm (left)	0.5	2.5	10.0	3.2	-0.8	-0.8	-1.2	1.3	-0.2	-0.3	-2.8	0.5
Arm fat mass (right)	0.9	3.6	13.5	-3.3	2.4	0.3	0.5	-0.5	0.5	1.2	3.7	0.3
Trunk predicted mass	0.4	2.1	10.8	-1.8	1.7	0.2	0.2	-0.4	0.7	1.0	3.3	0.2
Standing height	0.4	3.7	6.3	1.8	2.5	-1.7	-2.1	2.1	1.8	1.9	1.6	1.7
Length of working week for main job	2.5	2.8	5.5	-2.3	0.1	2.0	1.7	-2.1	-1.4	-1.2	1.4	-1.7
Exposure to tobacco smoke at home	0.5	0.6	1.3	-1.1	-0.8	0.4	0.1	-1.1	-0.7	-0.1	1.1	-0.5
Breastfed as a baby	3.6	4.5	7.6	2.4	1.6	-2.5	-2.4	2.8	1.6	1.9	-0.7	2.3
Tense / ‘highly strung’	0.2	0.3	1.0	-0.7	0.0	0.3	0.5	-0.7	-0.0	0.2	1.0	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.3	1.1	-1.3	-0.3	0.3	-0.4	-0.8	-0.7	-1.5	-0.5
Hair/balding pattern: Pattern 4	3.9	9.3	14.1	-2.9	-2.9	2.9	3.8	-3.1	-3.0	-3.4	-1.3	-3.5
Birth weight of first child	0.7	1.2	2.9	-0.5	-1.0	1.7	1.2	-0.9	-1.2	-0.8	1.3	-0.8
Peak expiratory flow (PEF)	0.2	0.4	0.9	-0.6	-0.9	0.5	0.5	-0.9	-0.2	-0.3	0.9	-0.6
Pulse wave reflection index	1.2	1.4	2.9	-1.4	-0.9	1.7	1.4	-1.1	-1.0	-0.8	1.0	-1.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.6	0.2	-0.8	0.1	0.1	-0.1	0.2	0.4	0.2	0.3
Loud music exposure frequency	2.8	3.1	5.3	1.9	0.7	-2.0	-2.1	1.8	1.2	2.3	0.3	2.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	2.1	0.9	1.5	-0.5	-0.5	1.1	0.7	0.7	0.2	0.5
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.2	-0.2	1.5	-0.1	-0.2	0.1	1.0	0.8	1.1	0.4
Blood clot in the leg (DVT)	2.5	3.2	6.2	-1.1	-1.8	1.6	1.5	-2.4	-2.5	-2.2	-0.8	-1.7
Medication: Paracetamol	1.2	2.0	4.7	-1.4	-0.4	1.6	1.6	-1.5	-2.2	-1.0	1.2	-1.0
Headache pain in last month	1.0	1.7	4.6	2.1	-0.2	-1.3	-1.4	1.4	0.3	1.4	-0.6	1.6
Medication for cholesterol, blood pressure or diabetes	6.5	10.8	15.1	-1.6	-3.9	3.3	3.3	-3.7	-3.5	-3.8	-1.4	-3.9
Glaucoma (self-reported)	5.0	5.8	9.4	-0.4	-2.6	2.3	2.4	-2.3	-2.6	-3.1	-2.3	-2.8
Gout (self-reported)	0.8	1.0	2.2	-1.5	1.2	0.9	1.3	-0.9	-0.5	-0.7	0.9	-0.9
Hypothyroidism/myxoedema (self-reported)	1.3	2.6	8.4	-2.9	0.1	1.9	1.5	-1.5	-0.8	-0.7	2.0	-1.4
Medication: Amlodipine	0.5	0.7	2.4	0.2	1.5	-0.9	-0.9	0.7	1.1	0.7	0.0	0.6
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.5	0.2	-0.1	-0.4	-0.3	-0.5	-0.2	0.7	0.5	0.5
Birth weight	4.5	9.9	15.8	-2.4	-1.5	3.3	3.6	-3.6	-3.5	-3.8	-1.0	-4.0
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.6	0.7	0.0	-0.4	-0.8	-0.1	-0.1	0.7	0.8	0.4
High blood pressure (siblings)	3.5	5.1	8.9	1.4	2.3	-2.1	-2.1	3.0	2.9	2.5	0.7	2.4
Forced vital capacity (FVC), Best measure	0.1	0.5	2.3	0.4	-1.5	-0.4	0.1	0.3	-0.6	-0.6	-0.8	-0.1
Body fat percentage	0.8	3.1	8.1	-2.0	2.8	-0.7	-0.6	0.5	1.2	1.9	2.8	1.2
Leg fat percentage (right)	1.4	4.9	11.8	-2.1	3.0	-1.3	-1.0	0.8	2.2	2.6	3.4	1.9
Arm fat-free mass (right)	0.5	2.5	13.6	-1.8	1.9	0.0	0.2	-0.7	0.5	1.2	3.7	0.2
Exposure to tobacco smoke outside home	0.1	0.1	0.3	0.5	-0.3	-0.2	-0.2	-0.1	-0.5	0.2	0.5	0.3
Comparative body size at age 10	0.0	0.1	0.8	-0.9	0.3	-0.1	-0.2	0.0	0.3	0.3	-0.1	0.1
Number of full brothers	0.4	0.6	1.5	0.5	-1.2	0.8	0.5	-0.6	-0.6	-0.8	-0.2	-1.1
Worry too long after embarrassment	0.1	0.2	0.5	-0.5	-0.6	0.6	0.4	0.1	0.1	0.1	0.7	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	1.5	0.3	1.2	-0.5	-0.4	0.3	0.2	0.2	0.3	0.2
Wheeze or whistling in the chest in last year	0.4	0.7	2.9	-1.2	0.5	0.5	0.3	-0.6	-0.9	0.3	1.7	0.1
Number of children fathered	0.1	0.2	0.6	0.1	0.8	-0.1	0.2	0.2	0.3	0.6	0.5	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.5	0.7	-0.4	0.5	0.4	0.3	-0.3	-0.3	-0.7	-0.4
Age at first live birth	1.0	1.8	4.3	1.2	0.7	-1.5	-1.3	2.1	1.1	0.5	-1.8	0.8
Pulse wave peak to peak time	0.3	0.3	1.0	0.7	-0.3	-1.0	-0.4	-0.1	0.5	-0.1	-0.9	0.2
Health satisfaction	0.3	0.4	1.0	-0.6	-0.7	0.7	0.3	-0.7	-1.0	-0.1	0.6	-0.2
Shortness of breath walking on level ground	0.7	0.8	3.9	-2.0	-1.0	0.1	0.3	-0.1	-0.6	0.6	1.2	0.5
Qualifications: College or University degree	0.4	1.1	4.7	2.2	0.8	-0.1	0.1	1.0	0.1	-0.2	-1.9	0.0
Eye problems/disorders: None of the above	0.5	0.6	1.3	0.8	0.7	-0.8	-0.9	0.7	1.2	0.7	0.3	0.8
Mouth/teeth dental problems: Loose teeth	0.6	0.7	3.1	-1.8	0.4	0.5	0.8	-0.7	-0.6	-0.5	0.7	-0.5
Emphysema/chronic bronchitis	0.2	0.3	1.0	0.1	0.3	0.6	0.1	-0.5	-1.0	-0.1	0.9	0.1
Medication for pain relief, constipation, heartburn	0.3	0.5	1.2	-0.5	-1.0	0.4	0.3	-1.1	0.5	-0.6	-0.3	-0.9
Neck or shoulder pain in last month	0.1	0.2	0.7	-0.0	-0.9	0.2	-0.1	0.2	0.6	0.2	0.4	0.1
Medication: Blood pressure	4.4	7.7	11.2	0.9	3.3	-2.8	-2.5	3.0	3.0	3.3	1.7	3.3
Angina (self-reported)	2.8	3.7	7.2	0.2	1.0	-1.4	-2.2	2.7	2.5	2.4	1.5	2.1
Migraine (self-reported)	0.3	0.4	1.0	0.2	-0.2	0.6	0.8	-0.8	-1.0	-0.5	-0.3	-0.7
Medication: Ibuprofen	0.3	0.4	1.1	-0.6	0.2	0.3	0.3	0.4	-1.0	0.4	1.0	0.7
Medication: Allopurinol	0.5	0.6	1.4	-1.2	1.1	0.6	0.6	-0.7	-0.5	-0.1	1.2	-0.4
Medication: Omeprazole	1.1	1.3	2.3	1.2	0.5	-1.3	-1.5	1.4	0.9	0.7	-1.2	1.0
Medication: Seretide 50 evohaler	1.4	1.6	3.7	-0.5	-1.3	0.9	0.9	-1.3	-1.9	-1.3	-1.3	-1.4
Mean time to correctly identify matches	0.6	1.1	2.3	1.5	1.5	-0.9	-1.2	0.8	1.2	0.7	-0.8	0.6
Heart disease (mother)	4.8	5.8	11.4	1.9	1.5	-2.1	-2.6	2.7	3.4	3.0	1.1	2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	1.2	0.4	0.7	-0.4	-0.5	0.2	1.1	0.5	0.1	0.3
Whole body fat mass	0.8	3.3	11.0	-2.3	2.9	-0.5	-0.3	0.1	0.9	1.8	3.3	0.9
Leg fat mass (right)	1.1	4.3	15.6	-2.7	2.9	-0.5	-0.2	0.0	1.4	2.0	4.0	1.0
Arm predicted mass (right)	0.6	2.9	14.3	-2.0	2.2	0.0	0.2	-0.5	0.6	1.4	3.8	0.3
Pulse rate, automated reading	0.2	0.8	4.1	-1.1	0.6	0.6	0.0	-0.4	0.2	0.8	2.0	0.0
Alcohol intake frequency.	0.6	1.4	3.1	0.5	1.2	-1.8	-0.9	0.9	1.2	1.3	-0.1	1.7
Comparative height size at age 10	0.8	4.1	8.7	0.6	3.0	-2.0	-2.1	2.2	1.7	2.2	1.5	2.2
Number of full sisters	0.3	0.3	0.7	-0.3	-0.8	0.3	0.7	-0.8	-0.7	-0.4	0.4	-0.4
Suffer from ‘nerves’	0.3	0.4	0.9	-1.0	0.9	0.6	0.7	-0.7	-0.3	-0.4	0.8	-0.2
Overall health rating	0.8	1.7	10.5	-1.6	0.8	0.7	0.2	-0.4	0.3	1.0	3.2	0.2
Chest pain or discomfort	0.4	0.6	2.6	-0.8	-0.7	0.5	0.0	0.0	-1.2	0.3	1.6	0.2
Had major operations	0.3	0.3	0.6	0.8	-0.2	-0.3	-0.4	0.7	-0.5	0.4	-0.6	0.8
Age at last live birth	0.4	0.6	1.6	0.5	0.3	-0.9	-0.7	1.3	1.1	0.5	-0.5	0.4
Family relationship satisfaction	1.8	2.2	3.7	1.2	0.5	-1.8	-1.9	1.7	1.6	1.6	0.1	1.6
Leg pain on walking	0.3	0.4	0.8	-0.4	-0.8	0.5	0.6	-0.9	-0.7	-0.7	-0.1	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.4	-1.0	1.4	-0.2	0.0	0.6	0.4	0.6	1.6	0.5
Commuting to job workplace: Car/motor vehicle	2.2	2.5	4.6	1.5	0.6	-2.1	-1.6	2.1	1.5	1.2	-1.4	1.6
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.7	-1.3	-1.1	0.2	0.7	0.1	-0.4	-0.1	0.5	0.1
Medication: Aspirin	0.8	1.1	3.1	0.4	0.8	-0.6	-0.7	1.2	1.8	1.3	1.1	0.7
Supplements: Vitamin C	0.2	0.2	0.7	0.1	0.2	-0.4	-0.8	0.8	0.4	0.1	-0.2	0.3
Knee pain experienced in last month	0.1	0.2	0.9	0.4	-0.2	-0.3	-0.6	0.0	0.1	-0.2	-0.9	0.1
Hypertension (Self-reported)	6.8	18.8	28.4	1.4	4.8	-4.4	-3.9	5.0	4.9	5.3	2.3	5.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.9	-0.3	-0.5	1.0	0.9	0.2	-0.6	-0.5	0.3	-0.3
Illnesses of father: Heart disease	0.8	1.1	2.7	0.9	1.3	-0.9	-1.0	1.6	0.2	1.3	0.0	1.1
Illnesses of siblings: Diabetes	3.5	4.2	7.2	2.7	0.7	-2.6	-2.5	2.1	1.7	2.3	-0.0	2.3
Smoking status: Previous	0.8	1.2	5.3	0.0	1.8	0.2	-0.5	0.2	0.9	1.0	2.3	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.8	-0.7	0.1	0.0	0.3	0.4	0.2	0.1	0.9	0.1
Whole body fat-free mass	0.5	2.8	14.0	-2.5	1.6	0.7	0.7	-0.9	0.2	0.8	3.7	-0.3
Leg fat-free mass (right)	0.7	3.6	13.2	-3.0	1.3	1.5	1.3	-1.6	-0.7	0.1	3.6	-1.1
Arm fat percentage (left)	0.8	3.1	11.2	-3.3	2.0	0.7	0.9	-0.9	0.0	0.8	3.2	-0.1
Average weekly red wine intake	0.3	0.4	1.5	0.2	0.6	0.8	0.4	-0.4	0.1	-0.9	-0.5	-1.2
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.9	0.3	0.8	-0.5	-0.2	0.3	-0.1	-0.5	-1.0	-0.2
Mood swings	0.1	0.2	1.0	-1.0	-0.4	0.0	0.4	0.3	0.6	-0.2	0.1	0.3
Loneliness, isolation	0.1	0.1	0.5	0.0	-0.4	-0.2	0.3	-0.5	0.2	0.0	0.7	-0.3
Long-standing illness, disability or infirmity	3.9	5.9	9.3	2.1	1.5	-2.3	-2.9	2.6	2.4	3.1	1.3	3.0
Ever had bowel cancer screening	3.2	3.7	5.8	2.3	1.9	-2.4	-2.3	2.0	1.2	1.8	-0.8	2.1
Diabetes diagnosed by doctor	6.0	9.8	16.3	2.9	2.2	-3.4	-4.0	2.6	3.3	4.0	1.2	3.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	0.7	-0.5	-0.7	-0.6	0.2	0.2	0.1	-0.4	0.2
Friendships satisfaction	0.4	0.5	2.4	-0.8	0.8	0.4	0.6	-0.0	0.5	0.6	1.6	0.2
Qualifications: nursing, teaching	0.7	1.1	4.8	2.2	0.4	-0.6	-1.3	0.7	0.5	0.5	-1.2	0.3
Commuting to job workplace: Walk	0.6	0.6	1.3	0.9	-0.1	0.6	0.4	-0.3	-1.1	-1.0	-1.1	-0.8
Eye problems/disorders: Cataract	1.4	1.6	4.9	-1.4	0.1	1.2	1.4	-1.1	-2.2	-1.3	-0.0	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.7	0.6	1.3	-0.4	0.0	0.0	0.6	0.8	1.0	0.8
Medication for cholesterol	2.0	3.1	7.4	-0.1	-2.7	1.0	1.4	-1.6	-1.8	-2.2	-1.9	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	3.9	2.0	1.4	-1.5	-1.1	1.7	0.2	1.0	-1.2	1.5
Back pain experienced in last month	0.7	1.0	3.5	-1.1	1.3	-0.3	-0.1	0.6	-0.5	1.1	1.9	0.9
Mineral and other dietary supplements	0.5	0.6	2.3	-0.6	-1.5	0.3	0.7	-1.0	0.1	-0.0	1.2	-0.3
Breast cancer (self-reported)	1.1	1.3	4.9	2.2	0.1	-0.9	-0.9	0.7	-0.1	0.0	-2.2	0.4
Asthma (self-reported)	0.5	1.0	2.1	-1.5	-0.7	1.0	0.8	-1.3	-1.3	-0.7	0.5	-0.6
Osteoporosis (self-reported)	0.7	0.9	1.8	-0.1	0.6	-1.0	-0.8	1.3	1.3	1.0	0.8	1.1
Osteoarthritis (self-reported)	1.2	1.6	4.7	0.3	-1.0	1.2	1.0	-1.2	-2.2	-1.4	-1.2	-1.2
Medication: Aspirin	1.0	1.3	3.4	0.7	1.0	-0.7	-0.8	1.3	1.8	1.4	1.1	0.8
Medication: Gliclazide	2.5	2.9	4.5	1.7	1.7	-1.7	-2.1	1.1	1.7	2.1	1.0	1.7
Illnesses of father: None of the above (group 1)	1.2	1.5	2.8	-1.0	-0.9	1.1	1.6	-1.3	-1.3	-1.7	-0.1	-1.4
Smoking status: Current	0.4	0.6	1.8	-0.2	-0.4	-1.1	-0.8	0.7	0.5	0.9	0.1	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	1.1	0.1	-1.1	-0.2	0.4	-0.5	-0.9	-0.2	-0.4	0.0
Whole body water mass	0.5	2.9	14.5	-2.5	1.7	0.7	0.6	-0.9	0.3	0.8	3.8	-0.2
Leg predicted mass (right)	0.6	3.4	13.2	-2.9	1.3	1.4	1.2	-1.5	-0.6	0.2	3.6	-0.9
Arm fat mass (left)	0.9	3.7	13.4	-3.4	2.4	0.6	0.7	-0.9	0.2	1.0	3.7	0.0
Number of self-reported non-cancer illnesses	1.0	1.7	2.9	0.5	1.3	-1.5	-1.5	1.4	0.9	1.6	0.6	1.7
Average weekly champagne plus white wine intake	0.7	1.0	2.1	0.6	-1.4	1.1	1.0	-0.2	-1.1	-1.0	-0.9	-1.0
Miserableness	0.2	0.4	1.4	0.6	-0.6	-0.9	-0.3	0.4	0.3	0.6	-0.2	1.2
Guilty feelings	0.5	0.7	2.0	-1.4	-1.0	0.7	1.1	-0.8	-0.2	-0.3	0.8	-0.2
Wears glasses or contact lenses	1.5	1.7	4.0	-0.2	2.0	-0.7	-1.0	0.9	1.0	1.8	1.4	1.6
Ever taken oral contraceptive pill	0.6	0.7	2.3	0.2	-1.5	0.0	0.3	-0.6	-0.8	-0.9	-1.1	-0.9
Hearing aid user	0.1	0.1	0.4	-0.6	0.5	0.3	0.5	0.0	-0.3	-0.1	0.2	-0.4
Mother’s age at death	0.6	0.7	1.9	0.9	1.0	-0.7	-1.4	0.9	0.8	0.7	-0.5	0.5
Financial situation satisfaction	0.3	0.4	1.7	-1.3	0.5	0.4	0.4	-0.8	-0.1	0.0	0.8	-0.2
Tinnitus: Yes, now most or all of the time	2.4	2.8	4.3	-1.8	-1.4	1.9	1.7	-1.6	-2.0	-2.1	-0.4	-1.6
Commuting to job workplace: Public transport	0.6	0.7	1.9	-0.1	-0.7	1.2	0.6	-1.4	-0.2	-0.7	0.4	-1.3
Eye problems/disorders: Glaucoma	3.4	4.0	6.5	-0.7	-1.7	1.9	2.2	-1.9	-2.3	-2.5	-2.0	-2.3
Medication: Blood pressure	2.2	4.2	7.4	0.2	2.6	-1.5	-1.6	1.7	2.7	2.6	2.0	2.3
Pain type(s) experienced in last month: Hip pain	1.2	1.5	4.2	-0.2	0.9	-1.0	-1.2	1.0	0.1	1.9	2.0	1.4
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.5	0.8	0.5	-0.5	-1.0	1.2	0.3	0.3	-1.1	0.5
High cholesterol (Self-reported)	0.4	0.7	1.8	0.7	1.3	-0.8	-0.7	0.7	1.1	0.5	-0.7	0.6
Medication: Bendroflumethiazide	1.6	2.4	4.8	-0.9	2.2	-0.9	-0.9	1.1	1.6	1.9	2.2	1.6
Medication: Paracetamol	2.1	3.3	6.2	-2.4	-0.6	2.0	2.0	-1.5	-2.3	-0.8	2.5	-0.9
Medication: Lisinopril	0.8	1.0	2.0	0.1	0.9	-0.6	-0.5	0.7	1.4	1.3	1.4	1.3
Medication: Atorvastatin	0.1	0.1	0.6	-0.8	0.4	0.3	0.0	-0.2	0.5	0.0	0.2	-0.1
Illnesses of father: High blood pressure	2.8	3.5	5.2	1.5	1.1	-2.0	-2.2	2.2	2.0	2.3	0.3	2.2
Alcohol drinker status: Never	3.0	3.5	5.6	1.0	1.8	-2.4	-1.9	2.3	1.9	2.0	0.0	2.3
Ever smoked	0.2	0.3	1.4	-0.9	0.3	0.2	-0.0	0.0	0.2	0.4	1.2	-0.2
Basal metabolic rate	0.6	3.2	15.4	-2.6	2.0	0.5	0.4	-0.7	0.5	1.1	3.9	-0.0
Leg fat percentage (left)	1.4	5.2	11.2	-2.0	3.2	-1.5	-1.2	1.0	2.3	2.7	3.3	2.0
Arm fat-free mass (left)	0.6	2.8	12.8	-2.1	2.2	-0.1	-0.0	-0.3	0.9	1.5	3.6	0.5
Number of operations (self-reported)	0.6	0.9	3.4	1.1	-0.7	-0.1	0.0	0.1	-1.4	-0.8	-1.9	-0.4
Average weekly beer plus cider intake	0.4	0.6	1.6	-1.1	0.2	0.4	0.8	-1.3	-0.9	-0.2	0.8	-0.5
Irritability	0.2	0.3	1.7	0.6	0.4	0.1	-0.0	-0.1	0.2	-0.7	-1.3	-0.5
Risk taking	0.3	0.4	1.8	1.3	0.1	0.1	-0.0	-0.6	0.3	-0.5	-1.0	-0.5
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.6	0.4	-0.2	0.5	0.2	-0.6	-0.8	0.1	-0.0	-0.2
Fractured/broken bones in last 5 years	2.2	2.8	5.1	1.2	1.3	-2.3	-1.8	2.3	1.4	1.3	-1.4	1.8
Age started oral contraceptive pill	0.3	0.3	0.6	0.1	0.7	-0.6	-0.3	0.7	0.6	0.4	-0.8	0.6
Diastolic blood pressure, automated reading	3.2	10.0	29.4	-2.4	4.8	-0.8	-1.1	1.4	2.9	3.6	5.4	2.5
Ever depressed for a whole week	0.9	1.1	2.4	0.9	1.5	-0.9	-0.7	1.0	0.3	1.4	0.7	1.4
Unable to work because of sickness or disability	1.2	1.6	3.6	0.1	-0.2	-1.9	-1.7	1.0	0.9	1.7	0.4	1.6
Commuting to job workplace: Cycle	0.6	0.7	2.7	0.8	0.4	-0.4	-0.6	1.1	1.1	-0.3	-1.6	-0.1
Myopia	1.5	2.1	6.7	-0.8	1.8	-0.3	-0.6	0.7	1.9	1.6	2.6	1.0
Vascular/heart problems diagnosed by doctor	7.4	20.1	31.7	-1.2	-5.2	4.0	4.1	-5.0	-5.1	-5.6	-3.1	-5.3
Cholesterol lowering medication	0.1	0.2	0.7	0.4	0.8	0.3	0.1	-0.2	0.7	0.2	-0.1	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.8	1.1	0.5	-0.9	-1.0	1.2	0.6	0.5	-1.3	0.8
Pain experienced in last month	0.2	0.3	0.9	0.7	0.3	-0.8	-0.4	0.2	1.0	0.0	-0.6	0.2
Supplements: Calcium	0.9	1.0	5.3	1.2	-0.8	-0.4	0.0	0.5	-0.6	-0.9	-2.3	-0.2
Basal cell carcinoma (self-reported)	2.2	2.7	5.2	0.1	-1.9	1.1	1.6	-1.6	-1.1	-2.3	-2.0	-1.9
Heart attack/myocardial infarction (self-reported)	3.5	4.6	8.1	0.3	2.7	-1.3	-1.6	1.9	2.6	2.9	2.7	2.0
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	4.0	-0.9	-1.5	1.3	1.1	-2.0	-2.0	-1.9	-0.8	-1.4
Heart disease (siblings)	1.8	2.2	6.2	0.1	2.5	-1.1	-1.5	1.7	1.8	1.5	0.5	1.3
Alcohol drinker status: Previous	1.5	1.7	3.1	0.4	1.7	-1.5	-0.7	1.2	1.8	1.4	0.8	1.5
Pack years of smoking	0.4	0.5	2.2	-1.5	0.6	-0.5	-0.5	0.1	-0.1	0.5	1.0	0.6
Impedance of whole body	1.3	6.8	20.6	4.5	0.0	-2.6	-2.8	2.9	1.4	1.1	-3.1	2.1
Leg fat mass (left)	1.1	4.5	15.9	-2.8	3.0	-0.5	-0.3	0.1	1.4	2.0	4.0	1.0
Arm predicted mass (left)	0.6	3.0	14.3	-2.1	2.2	-0.1	0.0	-0.2	0.9	1.5	3.8	0.6