Best TWAS P=2.95e-13 · Best GWAS P=6.94e-56 conditioned to 5.53e-41
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Lung | PVT1 | 0.19 | 0.12 | lasso | 2 | 0.09 | 3.1e-07 | 7.3 | 7.3 | 3.0e-13 | -0.49 | 0.99 | 0.00 | TRUE |
| 2 | GTEx | Skin Sun Exposed Lower leg | PVT1 | 0.17 | 0.00 | enet | 29 | 0.01 | 4.9e-02 | 7.5 | 6.8 | 9.0e-12 | -0.26 | 0.15 | 0.09 | TRUE |
| 3 | GTEx | Whole Blood | PVT1 | 0.12 | 0.07 | lasso | 4 | 0.06 | 6.3e-06 | 7.3 | 7.2 | 5.4e-13 | -0.47 | 0.97 | 0.01 | FALSE |
| 4 | METSIM | Adipose | FAM84B | 0.17 | 0.12 | lasso | 5 | 0.12 | 2.8e-17 | 6.3 | -6.2 | 7.3e-10 | 0.00 | 0.00 | 1.00 | TRUE |
| 5 | YFS | Blood | FAM84B | 0.29 | 0.20 | lasso | 10 | 0.21 | 2.5e-67 | 6.3 | -5.9 | 3.4e-09 | -0.01 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PVT1 | 0.06 | 0.04 | lasso | 4 | 0.04 | 4.2e-05 | 7.3 | 6.6 | 4.1e-11 | -0.45 | 0.49 | 0.02 | FALSE |