TWAS hub - FAM84B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.165	0.0364	1.1e-08	0.117	0.054	0.107	0.110	0.118	4.7e-17	1.4e-08	1.2e-15	4.1e-16	2.8e-17
2	YFS	Blood	0.295	0.0324	0.0e+00	0.200	0.186	0.206	0.209	0.211	1.9e-63	1.2e-58	1.8e-65	1.6e-66	2.5e-67

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Mother’s age at death	6.0	7.5	7.8	-2.8	-2.7
Blood Eosinophil Count	4.7	36.4	37.9	-6.2	-5.9
Blood White Count	4.5	33.6	34.9	-5.9	-5.7
Illnesses of siblings	4.3	6.0	6.8	2.3	2.6
Mean Putamen Volume	4.2	4.8	5.4	-2.0	-2.3
Chronic bronchitis/emphysema (mother)	3.8	4.4	4.6	2.0	2.1
Tinnitus: Yes, but not now, but have in the past	3.7	4.0	4.4	-1.9	-2.1
Maternal smoking around birth	3.6	5.2	6.1	2.5	2.1
Prospective memory result	3.6	4.5	4.6	2.1	2.1
Bipolar Disorder (2018)	3.5	5.6	6.5	-2.2	-2.5
Medication: Gliclazide	3.4	3.9	4.1	2.0	1.9
Commuting to job workplace: Cycle	3.3	4.0	4.3	-1.9	-2.1
Medication: Ventolin 100micrograms inhaler	3.2	4.1	4.5	-2.1	-1.9
Supplements: Vitamin C	3.2	3.8	4.5	-1.8	-2.1
Medication: Paracetamol	3.0	4.6	4.6	2.1	2.1
Ovarian Cancer	2.8	3.8	4.7	-1.7	-2.2
Number of self-reported non-cancer illnesses	2.8	4.8	4.8	-2.2	-2.2
Prostate Cancer	2.7	3.8	4.0	2.0	1.9
Illness, injury, bereavement, stress in last 2 years	2.7	3.3	4.0	-1.6	-2.0
Commuting to job workplace: Public transport	2.7	3.2	3.7	-1.7	-1.9
HbA1C	2.5	2.8	3.1	-1.8	-1.6
BMI	2.5	14.4	16.7	4.1	3.5
Hypothyroidism (self reported)	2.4	5.5	6.5	2.5	2.1
Medication for hormone replacement therapy	2.4	2.7	2.9	-1.7	-1.6
Hayfever, allergic rhinitis or eczema	2.4	5.3	6.0	-2.1	-2.4
Ever taken oral contraceptive pill	2.4	2.6	2.7	1.6	1.6
Medication: Paracetamol	2.3	3.7	3.8	1.9	1.9
Leg pain on walking	2.3	2.9	3.1	1.8	1.6
Osteoarthritis (self-reported)	2.3	2.9	3.3	-1.6	-1.8
Alzheimer’s Disease (including proxy)	2.2	3.2	3.7	-1.7	-1.9
Medication: Levothyroxine sodium	2.2	3.7	5.2	2.3	1.5
Type 2 Diabetes (T2D) (2012)	2.1	2.4	2.9	1.7	1.4
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.5	2.6	-1.6	-1.6
Qualifications: CSEs or equivalent	2.0	2.6	3.0	1.7	1.5
Financial difficulties in last 2 years	2.0	2.7	3.1	1.6	1.8
Age at last live birth	2.0	2.9	3.1	-1.6	-1.8
Supplements: Glucosamine	1.9	2.5	2.6	-1.6	-1.5
Alcohol usually taken with meals	1.9	3.0	3.1	-1.7	-1.8
High blood pressure (siblings)	1.9	2.8	3.3	-1.5	-1.8
Commuting to job workplace: Car/motor vehicle	1.9	2.1	2.2	1.4	1.5
Sensitivity / hurt feelings	1.8	3.2	3.5	1.7	1.9
Medication: Aspirin	1.8	2.3	2.4	-1.5	-1.5
Hypothyroidism/myxoedema (self-reported)	1.7	3.3	3.7	1.9	1.7
Health satisfaction	1.7	2.2	2.5	1.6	1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	3.6	-1.9	-1.9
Ever had bowel cancer screening	1.7	2.0	2.0	-1.4	-1.4
Alzheimer’s Disease (in mother)	1.6	1.8	2.0	-1.3	-1.4
Allergy or Eczema	1.6	4.3	5.0	-1.9	-2.2
Age when periods started (menarche)	1.6	3.8	4.6	-1.7	-2.1
Impedance of arm (right)	1.6	7.6	8.1	-2.8	-2.7
Heart disease (mother)	1.6	2.0	2.1	1.4	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	2.2	1.3	1.5
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	2.1	1.4	1.3
Medication: Aspirin	1.6	2.0	2.1	-1.4	-1.5
Age at First Birth	1.5	2.1	2.4	1.4	1.5
Supplements: Zinc	1.5	1.7	1.7	-1.3	-1.3
Body mass index (BMI)	1.5	6.2	7.2	2.7	2.3
Unable to work because of sickness or disability	1.5	1.9	2.3	-1.5	-1.3
Basal cell carcinoma (self-reported)	1.5	1.8	2.0	1.3	1.4
Bipolar Disorder or Schizophrenia	1.4	3.5	3.7	-1.9	-1.8
Hearing difficulty/problems with background noise	1.4	2.3	2.6	-1.6	-1.4
Pain all over the body in last month	1.4	1.5	1.5	-1.2	-1.2
Mouth/teeth dental problems: Dentures	1.4	2.3	2.8	1.3	1.7
Illnesses of mother	1.4	1.7	2.1	-1.4	-1.2
Arm fat-free mass (right)	1.4	7.2	8.0	2.8	2.5
Fluid intelligence score	1.3	2.6	2.8	-1.7	-1.6
Impedance of arm (left)	1.3	6.1	6.2	-2.5	-2.4
Arm fat mass (right)	1.3	5.3	6.4	2.5	2.0
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	2.4	1.6	1.4
Leg fat percentage (right)	1.3	4.7	5.1	2.3	2.0
Leg fat mass (right)	1.3	5.2	6.0	2.5	2.1
Asthma (self-reported)	1.3	2.5	2.8	-1.7	-1.5
Pain type(s) experienced in last month: Hip pain	1.3	1.6	1.9	-1.2	-1.4
Bipolar Disorder (2011)	1.2	1.2	1.6	-1.3	-0.9
LDL Cholesterol	1.2	1.9	1.9	-1.4	-1.4
Hair/balding pattern: Pattern 4	1.2	2.8	2.9	1.7	1.7
Arm predicted mass (right)	1.2	5.9	6.6	2.6	2.3
Arm fat percentage (left)	1.2	4.7	5.6	2.4	1.9
Average weekly red wine intake	1.2	1.8	1.9	-1.3	-1.4
Medication for cholesterol	1.2	1.8	1.9	1.4	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	2.6	1.6	1.6
Supplements: Fish oil (including cod liver oil)	1.2	1.6	1.8	1.3	1.2
Leg fat mass (left)	1.2	4.6	5.4	2.3	1.9
Hair/balding pattern: Pattern 2	1.1	1.4	1.7	1.3	1.1
Qualifications: None of the above	1.1	2.4	2.4	1.6	1.5
Hip circumference	1.1	4.7	5.4	2.3	2.0
Breastfed as a baby	1.1	1.4	1.7	-1.3	-1.1
Ever smoked	1.1	1.9	2.3	-1.5	-1.3
Vascular/heart problems diagnosed by doctor	1.1	2.9	3.2	1.8	1.6
Pack years of smoking	1.1	1.6	1.8	1.4	1.2
Impedance of whole body	1.1	5.5	6.1	-2.5	-2.2
Arm predicted mass (left)	1.1	5.8	6.2	2.5	2.3
Ulcerative Colitis	1.0	1.4	1.9	-1.4	-1.0
Medication: Metformin	1.0	1.4	1.7	1.1	1.3
Arm fat percentage (right)	1.0	4.0	4.8	2.2	1.8
Asthma	1.0	2.0	2.1	-1.4	-1.4
Emphysema/chronic bronchitis	1.0	1.1	1.2	-1.1	-1.1
Whole body fat mass	1.0	4.3	5.2	2.3	1.9
Loneliness, isolation	1.0	1.4	2.0	1.4	0.9
Arm fat mass (left)	1.0	4.2	5.0	2.2	1.8
Hearing aid user	1.0	1.1	1.5	1.2	0.9
Illnesses of father: High blood pressure	1.0	1.3	1.5	-1.2	-1.0
Leg fat percentage (left)	1.0	3.7	4.1	2.0	1.8
Depression (Nagel 2018)	0.9	1.3	2.0	1.4	0.8
Schizophrenia vs Biploar Disorder	0.9	1.2	1.5	1.0	1.2
Pack years adult smoking proportion	0.9	1.4	1.5	1.2	1.1
Allergy	0.9	2.1	2.5	1.3	1.6
Weight	0.9	4.4	5.0	2.2	2.0
Qualifications: College or University degree	0.9	2.9	3.7	-1.9	-1.5
Illnesses of siblings: Diabetes	0.9	1.1	1.4	-1.2	-0.9
Illnesses of father: None of the above (group 1)	0.9	1.1	1.2	1.1	1.0
Basal metabolic rate	0.9	5.0	5.5	2.3	2.1
Arm fat-free mass (left)	0.9	4.6	4.9	2.2	2.1
Supplements: Calcium	0.9	1.0	1.3	-0.9	-1.1
Leg fat-free mass (left)	0.8	4.4	5.3	2.3	1.9
Leg predicted mass (left)	0.8	4.2	5.0	2.2	1.8
Waist circumference	0.8	3.1	3.5	1.9	1.6
Father’s age at death	0.8	1.0	1.1	1.0	1.0
Body fat percentage	0.8	3.0	3.7	1.9	1.6
Whole body fat-free mass	0.8	4.4	4.6	2.1	2.0
Mood swings	0.8	1.5	1.6	1.2	1.3
Eye problems/disorders: Cataract	0.8	0.9	0.9	-1.0	-0.9
Whole body water mass	0.8	4.4	4.6	2.1	2.0
Number of operations (self-reported)	0.8	1.3	1.4	-1.0	-1.2
Cardiovascular Disease	0.7	2.4	2.9	-1.7	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.4	1.2	0.6
Trunk fat mass	0.7	3.2	3.9	2.0	1.6
Noisy workplace	0.7	0.9	1.0	0.9	1.0
Tense / ‘highly strung’	0.7	1.2	1.3	-1.0	-1.2
Peak expiratory flow (PEF)	0.7	1.6	2.0	1.4	1.1
Shortness of breath walking on level ground	0.7	0.8	1.1	0.7	1.0
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.1	0.7	1.1
Neck or shoulder pain in last month	0.7	1.0	1.0	-1.0	-1.0
Hypertension (Self-reported)	0.7	1.9	2.1	-1.4	-1.3
Leg fat-free mass (right)	0.7	3.9	4.6	2.2	1.8
Leg predicted mass (right)	0.7	3.5	4.2	2.1	1.7
Average weekly champagne plus white wine intake	0.7	1.0	1.1	-1.1	-0.9
Financial situation satisfaction	0.7	0.9	1.1	0.8	1.1
Eye problems/disorders: Glaucoma	0.7	0.8	1.3	0.5	1.2
Verbal and Numeric Reasoning (VNR)	0.6	1.5	1.7	-1.3	-1.1
Lung FEV1/FVC ratio	0.6	3.0	3.6	1.9	1.5
Ever used hormone-replacement therapy (HRT)	0.6	0.8	0.8	0.9	0.9
Fed-up feelings	0.6	1.1	1.3	1.0	1.1
Impedance of leg (left)	0.6	2.8	3.6	-1.9	-1.4
Past tobacco smoking	0.6	1.2	1.4	1.2	1.0
Diabetes (self-reported)	0.6	0.9	1.0	0.8	1.0
Trunk fat-free mass	0.6	3.5	3.6	1.9	1.9
Happiness	0.6	0.8	0.9	0.8	0.9
Trunk predicted mass	0.6	3.5	3.6	1.9	1.9
Exposure to tobacco smoke outside home	0.6	0.8	1.1	1.1	0.7
Number of children fathered	0.6	0.7	0.8	0.8	0.9
Angina (self-reported)	0.6	0.8	0.9	-0.7	-1.0
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.0	0.6	1.0
Long-standing illness, disability or infirmity	0.6	1.0	1.1	0.9	1.1
Diabetes diagnosed by doctor	0.6	1.0	1.1	1.0	1.0
Medication: Blood pressure	0.6	1.1	1.3	-1.1	-1.0
Ever had prostate specific antigen (PSA) test	0.6	0.7	0.8	-0.9	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	0.9	-0.7	-0.9
Major Depression (MDD)	0.5	0.6	0.9	0.9	0.6
Lupus	0.5	0.8	1.0	0.7	1.0
Angina	0.5	0.7	0.8	-0.7	-0.9
Trunk fat percentage	0.5	1.9	2.5	1.6	1.2
Hand grip strength (right)	0.5	1.2	1.6	-0.9	-1.3
Taking other prescription medications	0.5	0.8	0.8	-0.9	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.4	1.2	0.5
Medication: Ramipril	0.5	0.6	0.9	-0.6	-0.9
Neuroticism score	0.5	1.0	1.3	1.2	0.8
Medication: Allopurinol	0.5	0.7	1.0	-0.6	-1.0
Smoking status: Previous	0.5	0.7	1.0	-1.0	-0.7
Guilty feelings	0.5	0.7	1.0	1.0	0.6
Medication: Atorvastatin	0.5	0.6	1.1	-0.4	-1.1
Risk taking	0.5	0.8	1.1	-1.0	-0.7
Crohns Disease (2017)	0.4	0.9	1.2	1.1	0.8
Breast Cancer	0.4	0.8	0.9	-1.0	-0.9
Fasting Glucose	0.4	0.5	0.6	0.8	0.6
Schizophrenia (2014)	0.4	0.8	1.2	-1.1	-0.7
Triglycerides	0.4	0.6	0.7	-0.8	-0.7
Blood Platelet Count	0.4	4.4	5.2	-2.3	-1.9
Blood Red Count	0.4	4.3	5.3	1.8	2.3
Systolic Blood Pressure	0.4	1.8	2.4	-1.6	-1.1
Smoking Status	0.4	0.9	1.3	-1.1	-0.8
Type 2 Diabetes (T2D) (2018)	0.4	0.8	0.9	1.0	0.8
Frequency of depressed mood in last 2 weeks	0.4	0.6	0.9	1.0	0.4
Number of incorrect matches in round	0.4	0.7	1.2	1.1	0.6
Nervous feelings	0.4	0.7	1.1	1.1	0.6
Had menopause	0.4	0.4	0.5	-0.6	-0.7
Alcohol intake versus 10 years previously	0.4	0.5	0.7	0.6	0.9
Blood clot in the leg (DVT)	0.4	0.5	0.5	-0.7	-0.7
Gout (self-reported)	0.4	0.5	0.8	-0.5	-0.9
Number of full brothers	0.4	0.5	0.5	-0.7	-0.7
Suffer from ‘nerves’	0.4	0.7	1.1	1.1	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.7	-0.4	-0.8
Friendships satisfaction	0.4	0.5	0.9	0.5	0.9
Back pain experienced in last month	0.4	0.7	0.7	0.8	0.9
Medication: Lisinopril	0.4	0.5	0.6	0.7	0.8
Ever depressed for a whole week	0.4	0.5	0.6	-0.8	-0.7
Myopia	0.4	0.6	0.6	-0.7	-0.8
Heart disease (siblings)	0.4	0.5	0.7	-0.6	-0.9
Reaction Time	0.3	0.5	1.0	-1.0	-0.3
Rheumatoid Arthritis	0.3	0.4	0.5	0.7	0.6
Waist Hip Ratio (WHR)	0.3	1.2	1.4	-1.2	-1.0
Relative age of first facial hair	0.3	0.6	0.6	0.7	0.8
Vitamin and mineral supplements	0.3	0.4	0.6	-0.8	-0.5
Severe depression (siblings)	0.3	0.3	0.7	-0.1	-0.8
Impedance of leg (right)	0.3	1.3	1.8	-1.3	-0.9
High blood pressure	0.3	0.8	0.9	-1.0	-0.8
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	0.5	-0.4	-0.7
Medication: Simvastatin	0.3	0.4	0.5	-0.7	-0.5
Qualifications: A levels/AS levels or equivalent	0.3	0.7	0.9	-0.9	-0.8
Medication: Cholesterol lowering	0.3	0.5	0.6	-0.7	-0.8
Depression (self-reported)	0.3	0.4	0.4	-0.6	-0.6
Medication: Lansoprazole	0.3	0.3	0.4	0.4	0.6
Length of working week for main job	0.3	0.3	0.4	0.6	0.5
Glaucoma (self-reported)	0.3	0.4	0.7	0.1	0.8
Medication: Blood pressure	0.3	0.5	0.7	-0.8	-0.5
Alcohol intake frequency.	0.3	0.7	0.8	0.9	0.7
Had major operations	0.3	0.3	0.3	-0.6	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	0.4	0.7
Qualifications: nursing, teaching	0.3	0.4	0.8	-0.9	-0.2
Ulcerative Colitis (UC)	0.2	0.4	0.6	-0.8	-0.5
Serious illness, injury or assault to yourself	0.2	0.3	0.4	-0.6	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.4	-0.6	-0.6
Mouth/teeth dental problems	0.2	0.3	0.5	-0.4	-0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	0.7	0.8	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.4	0.6	0.1
Birth weight of first child	0.2	0.4	0.4	-0.6	-0.6
Pulse wave reflection index	0.2	0.2	0.4	-0.2	-0.6
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.3	0.6	0.4
Headache pain in last month	0.2	0.3	0.6	0.3	0.8
Medication: Amlodipine	0.2	0.3	0.3	-0.6	-0.4
Birth weight	0.2	0.5	1.0	0.1	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.3	-0.5	-0.6
Age at first live birth	0.2	0.4	0.5	-0.6	-0.7
Medication: Ibuprofen	0.2	0.2	0.4	0.6	0.2
Medication: Omeprazole	0.2	0.3	0.4	-0.4	-0.6
Mean time to correctly identify matches	0.2	0.4	0.7	-0.8	-0.4
Comparative height size at age 10	0.2	1.0	1.5	0.7	1.2
Illnesses of father: Heart disease	0.2	0.3	0.3	0.6	0.5
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.3	-0.5	-0.3
Irritability	0.2	0.4	0.4	-0.6	-0.6
Fractured/broken bones in last 5 years	0.2	0.2	0.3	0.4	0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.3	-0.4	-0.5
Depressed Affect (Nagel 2018)	0.1	0.3	0.3	0.5	0.5
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.3	-0.6	-0.3
Schizophrenia (2018)	0.1	0.3	0.5	-0.7	-0.3
Alzheimer’s Disease (in father)	0.1	0.2	0.2	-0.3	-0.4
Body Mass Index (BMI) (2010)	0.1	0.1	0.1	0.2	0.3
Coronary Artery Disease (CAD)	0.1	0.2	0.3	0.6	-0.0
Crohns Disease (2012)	0.1	0.1	0.1	-0.3	-0.3
HDL Cholesterol	0.1	0.1	0.2	0.4	0.4
Neuroticism (2016)	0.1	0.1	0.2	0.4	0.3
Respiratory disease	0.1	0.2	0.3	-0.6	-0.3
Lung FVC	0.1	0.4	0.6	-0.8	-0.6
Neuroticism	0.1	0.2	0.4	-0.0	-0.6
Hair Pigment	0.1	2.0	2.8	1.1	1.7
Tanning	0.1	1.5	1.8	-1.1	-1.3
Average weekly spirits intake	0.1	0.1	0.1	-0.2	-0.3
Hearing difficulty/problems: Yes	0.1	0.2	0.2	-0.4	-0.5
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.4	0.3
Medication: Co-codamol	0.1	0.1	0.2	0.4	0.1
Diabetes (father)	0.1	0.1	0.1	-0.2	-0.3
Townsend deprivation index at recruitment	0.1	0.2	0.3	-0.1	-0.5
Current tobacco smoking	0.1	0.2	0.4	-0.6	-0.3
Average weekly fortified wine intake	0.1	0.1	0.2	-0.4	-0.3
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.1	-0.3	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.1	-0.4	-0.4
Multivitamins +/- minerals	0.1	0.1	0.2	0.3	0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	0.5	-0.1
Medication: Atenolol	0.1	0.1	0.2	0.4	0.3
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.3	-0.5
Heart attack	0.1	0.1	0.2	0.2	0.4
Time employed in main current job	0.1	0.1	0.2	0.4	0.2
Worrier / anxious feelings	0.1	0.2	0.4	0.6	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.1	0.3	0.3
Lung cancer (father)	0.1	0.1	0.1	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.5	0.6	0.6	0.8
Loud music exposure frequency	0.1	0.1	0.2	0.5	0.2
Comparative body size at age 10	0.1	0.2	0.3	0.5	0.2
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.5	-0.0
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	-0.6	-0.3
Migraine (self-reported)	0.1	0.2	0.3	0.3	0.5
Medication: Seretide 50 evohaler	0.1	0.1	0.2	-0.4	-0.0
Number of full sisters	0.1	0.2	0.3	-0.2	0.6
Overall health rating	0.1	0.2	0.2	0.5	0.4
Chest pain or discomfort	0.1	0.1	0.2	-0.3	-0.4
Family relationship satisfaction	0.1	0.1	0.1	0.3	0.2
Commuting to job workplace: Walk	0.1	0.1	0.2	0.1	0.5
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	0.2	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	0.1	0.5
Mineral and other dietary supplements	0.1	0.1	0.1	0.4	0.2
Miserableness	0.1	0.1	0.2	0.2	0.4
Wears glasses or contact lenses	0.1	0.1	0.1	-0.2	-0.4
High cholesterol (Self-reported)	0.1	0.2	0.3	-0.3	-0.5
Medication: Bendroflumethiazide	0.1	0.2	0.2	-0.3	-0.4
Cholesterol lowering medication	0.1	0.2	0.2	-0.5	-0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.2	0.3	0.5
Alcohol drinker status: Previous	0.1	0.1	0.2	0.0	-0.5
Neuroticism (Nagel 2018)	0.0	0.1	0.1	0.4	-0.0
Worry (Nagel 2018)	0.0	0.1	0.2	0.4	-0.2
Irritable Bowel Disease (IBD)	0.0	0.1	0.1	-0.3	-0.3
Primary Biliary Cirrhosis	0.0	0.0	0.0	-0.1	-0.1
Heel T-Score	0.0	0.1	0.1	-0.2	-0.3
Height	0.0	0.2	0.2	0.5	0.5
Chronotype (morning person)	0.0	0.0	0.1	0.0	-0.3
Hand grip strength (left)	0.0	0.0	0.0	0.2	-0.0
Number of treatments/medications taken	0.0	0.1	0.1	-0.3	-0.2
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	0.2	-0.2
Systolic blood pressure, automated reading	0.0	0.1	0.2	0.4	0.3
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	-0.0	-0.3
Diabetes (mother)	0.0	0.0	0.1	0.2	-0.2
Relative age voice broke	0.0	0.0	0.0	-0.1	-0.1
Stomach or abdominal pain in last month	0.0	0.0	0.0	-0.0	0.0
Sitting height	0.0	0.3	0.3	0.5	0.5
High blood pressure (mother)	0.0	0.0	0.0	0.2	-0.2
Had other major operations	0.0	0.0	0.0	-0.2	-0.2
Forced vital capacity (FVC)	0.0	0.1	0.2	0.2	0.4
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.1	0.1	-0.2
Falls in the last year	0.0	0.1	0.1	-0.1	0.3
Hair/balding pattern: Pattern 3	0.0	0.0	0.0	-0.1	0.1
Number of live births	0.0	0.0	0.0	-0.1	0.0
Pulse rate	0.0	0.0	0.0	0.2	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.1	0.2	-0.1
Pulse wave Arterial Stiffness index	0.0	0.1	0.1	0.0	-0.3
Standing height	0.0	0.4	0.5	-0.7	-0.5
Exposure to tobacco smoke at home	0.0	0.0	0.0	-0.1	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.2	-0.3
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	-0.1	-0.2
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.0	0.1	0.2
Forced vital capacity (FVC), Best measure	0.0	0.0	0.0	-0.2	0.1
Worry too long after embarrassment	0.0	0.0	0.0	0.1	0.0
Wheeze or whistling in the chest in last year	0.0	0.0	0.0	0.2	-0.0
Pulse wave peak to peak time	0.0	0.0	0.0	-0.1	0.2
Pulse rate, automated reading	0.0	0.0	0.1	0.1	0.2
Knee pain experienced in last month	0.0	0.0	0.0	-0.1	0.1
Breast cancer (self-reported)	0.0	0.0	0.0	0.0	0.2
Osteoporosis (self-reported)	0.0	0.0	0.0	-0.1	-0.1
Smoking status: Current	0.0	0.0	0.0	-0.1	0.0
Alcohol drinker status: Never	0.0	0.0	0.0	0.0	-0.0
Average weekly beer plus cider intake	0.0	0.0	0.1	0.3	0.1
Age started oral contraceptive pill	0.0	0.0	0.1	-0.1	-0.3
Diastolic blood pressure, automated reading	0.0	0.0	0.0	-0.1	-0.1
Pain experienced in last month	0.0	0.1	0.1	-0.3	-0.2

Hub : Genes

FAM84B

Models

Trait associations