Best TWAS P=4.28e-21 · Best GWAS P=7.35e-97 conditioned to 4.25e-85
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ADO | 0.04 | 0.01 | blup | 465 | 0.02 | 1.8e-03 | -4.9 | -9.1 | 6.9e-20 | 0.52 | 0.07 | 0.49 | TRUE |
| 2 | GTEx | Muscle Skeletal | ADO | 0.15 | 0.16 | lasso | 8 | 0.16 | 1.1e-15 | -5.5 | -5.7 | 1.1e-08 | 0.56 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Testis | ADO | 0.21 | 0.23 | lasso | 7 | 0.22 | 6.6e-10 | -5.5 | 5.5 | 3.2e-08 | -0.57 | 0.93 | 0.07 | FALSE |
| 4 | GTEx | Thyroid | EGR2 | 0.08 | 0.01 | enet | 40 | 0.02 | 6.4e-03 | -2.6 | -5.7 | 9.8e-09 | 0.16 | 0.57 | 0.05 | FALSE |
| 5 | METSIM | Adipose | ADO | 0.07 | 0.00 | bslmm | 461 | 0.01 | 3.4e-02 | 8.9 | 5.3 | 1.3e-07 | 0.11 | 0.53 | 0.05 | TRUE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADO | 0.07 | 0.06 | blup | 53 | 0.05 | 2.5e-06 | -4.9 | -7.8 | 4.2e-15 | 0.51 | 0.99 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | EGR2 | 0.12 | 0.10 | blup | 56 | 0.10 | 1.4e-03 | -5.6 | -9.4 | 4.3e-21 | 0.35 | 0.02 | 0.29 | TRUE |