Hub : Genes

ADO

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0360	0.0160	4.7e-03	0.012	0.019	-0.001	0.018	0.000	1.0e-02	1.8e-03	4.1e-01	0.0023	2.8e-01
2	GTEx	Muscle Skeletal	0.1473	0.0351	5.4e-12	0.165	NA	0.158	NA	0.162	6.1e-16	NA	2.6e-15	NA	1.1e-15
3	GTEx	Stomach	0.1910	0.0700	2.2e-03	0.010	NA	0.105	NA	0.017	1.0e-01	NA	1.0e-05	NA	5.2e-02
4	GTEx	Testis	0.2050	0.0550	3.9e-07	0.234	NA	0.184	NA	0.215	9.3e-11	NA	1.4e-08	NA	6.6e-10
5	METSIM	Adipose	0.0702	0.0296	4.9e-04	0.004	0.006	0.001	0.006	0.005	6.3e-02	3.9e-02	2.3e-01	0.0340	4.9e-02
6	ROSMAP	Brain Pre-frontal Cortex	0.0584	0.0218	1.1e-04	0.038	0.019	0.042	0.020	0.060	1.0e-05	1.6e-03	3.3e-06	0.0011	3.1e-08
7	TCGA	Breast Invasive Carcinoma	0.0316	0.0155	1.2e-06	0.016	0.028	0.025	NA	0.023	1.9e-04	1.8e-06	5.1e-06	NA	1.1e-05
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0980	0.0416	2.1e-05	0.032	0.034	0.057	NA	0.052	1.3e-04	9.0e-05	4.6e-07	NA	1.7e-06
9	TCGA	Brain Lower Grade Glioma	0.0744	0.0323	3.3e-07	0.059	0.049	0.040	NA	0.045	2.7e-07	2.5e-06	2.0e-05	NA	6.3e-06
10	TCGA	Lung Adenocarcinoma	0.1436	0.0594	2.3e-06	0.046	0.046	0.044	NA	0.046	4.1e-06	3.8e-06	5.8e-06	NA	4.1e-06
11	TCGA	Pancreatic Adenocarcinoma	0.0620	0.0350	8.3e-03	0.043	0.008	0.008	NA	0.005	6.6e-03	1.4e-01	1.4e-01	NA	1.9e-01
12	TCGA	Thyroid Carcinoma	0.1160	0.0420	8.6e-08	0.096	0.069	0.076	NA	0.089	1.3e-09	2.9e-07	7.9e-08	NA	5.2e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	2.4	3.7	8.0	-1.0	-2.1	0.9	1.9	0.0	-2.1	-2.6	-2.1	-1.6	-1.6	-2.5	-2.8
Bipolar Disorder or Schizophrenia	0.8	1.9	4.3	-0.2	-1.6	1.1	2.1	0.8	0.2	-1.9	-1.8	-2.0	-0.5	-0.9	-1.7
Depressed Affect (Nagel 2018)	0.3	0.6	3.0	-0.0	-1.0	1.7	0.8	0.8	-0.0	-0.3	-0.6	-0.9	0.1	-0.4	-0.8
Depression (Nagel 2018)	1.4	2.1	6.0	-0.9	-2.4	-0.6	2.1	0.8	-1.2	-1.7	-1.1	-1.9	-0.8	-1.2	-1.6
Intelligence (Savage-Jansen 2018)	1.3	4.1	8.4	-0.0	1.7	-0.8	-1.3	2.9	2.6	2.0	2.4	0.6	2.8	2.4	2.2
Neuroticism (Nagel 2018)	0.3	0.7	1.9	-1.3	-1.1	0.3	1.2	0.1	-0.2	-0.8	-0.6	-1.4	-0.1	-0.7	-0.9
Schizophrenia (2018)	0.4	0.8	3.7	0.6	-0.3	0.6	1.1	1.0	1.9	-0.3	-0.6	-1.3	0.6	0.9	0.1
Schizophrenia vs Biploar Disorder	6.3	8.3	15.0	2.2	3.0	0.9	-2.9	1.4	3.9	3.7	3.0	2.5	2.1	3.9	3.4
Worry (Nagel 2018)	1.6	3.4	6.9	-2.6	-1.8	-1.3	2.1	-1.0	-1.7	-2.2	-1.4	-1.9	-1.0	-2.3	-1.7
Alzheimer’s Disease (in mother)	0.2	0.2	0.6	-0.5	-0.2	-0.2	0.3	-0.7	-0.1	0.4	-0.4	0.3	-0.6	-0.4	-0.8
Alzheimer’s Disease (in father)	0.6	0.7	2.2	-0.5	-0.1	0.2	0.1	1.4	0.3	0.4	1.5	-0.2	1.4	0.8	0.8
Alzheimer’s Disease (including proxy)	0.1	0.1	0.6	-0.5	-0.2	-0.3	0.3	-0.0	-0.4	-0.0	0.1	0.1	-0.1	-0.5	-0.8
Crohns Disease (2017)	15.9	34.9	72.4	7.9	8.5	1.6	-8.2	2.4	4.3	6.7	5.7	7.4	2.5	5.1	5.0
Irritable Bowel Disease (IBD)	11.9	28.4	69.0	7.8	8.3	1.5	-7.6	1.3	3.2	5.7	4.7	6.7	1.6	4.4	4.2
Ulcerative Colitis (UC)	2.8	5.3	17.5	4.1	4.2	1.1	-3.5	-0.8	0.1	1.6	1.5	2.7	-0.4	1.1	1.1
Major Depression (MDD)	2.8	3.3	8.6	-1.7	-1.3	-0.2	1.9	-0.2	-1.8	-2.9	-1.5	-2.5	-0.8	-2.5	-2.3
Reaction Time	1.2	2.2	5.4	0.3	-1.4	-0.1	0.7	-0.5	-2.2	-1.2	-1.8	0.2	-2.3	-2.0	-2.3
Verbal and Numeric Reasoning (VNR)	1.1	2.5	6.0	-0.3	1.1	0.2	-0.4	2.1	2.2	1.7	1.7	-0.3	2.4	2.2	1.7
Breast Cancer	4.0	9.5	33.8	-2.7	1.9	3.3	-0.8	3.4	3.2	0.5	2.8	-2.1	5.8	2.8	3.9
Ovarian Cancer	1.0	1.3	7.1	-1.1	-0.9	-2.7	1.1	1.8	0.1	-0.2	0.5	-0.9	0.2	0.2	-0.6
Prostate Cancer	0.1	0.2	1.0	0.2	-0.2	1.0	-0.2	0.8	-0.5	-0.1	0.3	-0.1	-0.2	-0.2	-0.3
Age at First Birth	1.3	2.0	5.5	-0.2	1.9	-1.5	-1.5	0.2	0.8	0.9	2.3	1.3	1.6	0.9	1.8
Bipolar Disorder (2011)	1.6	1.5	6.1	0.0	0.2	1.3	-0.3	-2.5	-1.7	-1.2	-0.9	0.2	-1.2	-1.6	-1.0
Body Mass Index (BMI) (2010)	0.4	0.5	1.6	0.8	-0.4	0.9	0.1	0.6	-0.7	-0.6	-0.7	-0.3	-0.9	-0.5	-1.3
Coronary Artery Disease (CAD)	0.6	0.7	6.4	-0.6	-0.0	-2.5	-0.0	0.5	0.1	-0.4	0.1	-0.7	0.7	-0.2	0.2
Crohns Disease (2012)	15.2	24.4	51.5	5.9	7.2	2.1	-7.1	1.8	3.6	5.4	4.9	6.3	2.9	4.1	4.3
Mean Putamen Volume	2.6	2.9	5.6	-1.4	-1.5	-1.2	1.4	-1.3	-1.7	-1.7	-2.4	-0.9	-2.2	-2.2	-2.0
Fasting Glucose	1.5	1.8	4.8	0.6	-1.2	1.0	0.8	-1.8	-1.0	-0.7	-2.0	-0.6	-2.2	-1.3	-1.8
HbA1C	3.2	3.6	7.4	0.9	2.3	0.8	-2.0	0.9	1.6	2.7	1.7	2.1	2.2	2.3	2.0
HDL Cholesterol	0.3	0.4	1.7	-0.6	-0.2	-1.3	0.5	-0.8	-0.7	-0.5	-0.6	-0.0	-0.7	-0.6	-0.5
LDL Cholesterol	0.6	0.9	2.9	-1.5	0.1	-1.7	-0.7	-0.2	0.7	1.0	0.8	0.7	0.6	1.0	1.0
Lupus	0.9	1.4	5.2	-2.3	-0.5	0.4	0.7	1.0	1.2	0.5	1.3	-1.2	1.3	1.3	0.9
Neuroticism (2016)	0.2	0.3	1.0	0.3	-1.0	0.3	0.7	-0.5	-0.2	-0.3	-0.4	-0.1	-0.8	-0.6	-0.7
Primary Biliary Cirrhosis	0.3	0.4	0.7	-0.0	0.6	0.6	-0.7	0.4	0.9	0.8	0.4	0.9	0.3	0.5	0.8
Rheumatoid Arthritis	0.3	0.4	1.2	-0.7	-0.6	0.1	0.3	-0.1	1.1	0.6	-0.1	-0.4	0.3	1.0	1.0
Schizophrenia (2014)	0.2	0.5	2.1	1.0	-0.0	1.5	0.6	0.1	0.9	-0.5	-0.6	-0.6	-0.4	0.1	-0.5
Triglycerides	1.0	1.6	4.0	0.9	0.7	0.9	-0.7	2.0	2.0	0.3	0.9	-0.2	2.0	1.0	1.6
Type 2 Diabetes (T2D) (2012)	2.0	2.3	5.2	0.1	1.1	2.1	-1.4	0.6	2.3	1.3	1.2	0.4	1.8	1.8	2.2
Ulcerative Colitis	2.0	2.9	12.3	2.9	3.5	0.7	-2.6	-1.2	-0.2	0.6	0.7	1.9	-0.4	0.3	0.6
Blood Eosinophil Count	3.0	22.8	83.4	-9.1	-5.7	0.5	5.5	5.3	1.8	-3.8	-2.3	-7.8	3.8	-0.2	-0.5
Blood Platelet Count	6.4	73.9	190.4	-8.5	-8.9	-13.8	8.6	-4.4	-8.9	-8.2	-7.1	-7.5	-7.4	-8.6	-8.4
Blood Red Count	1.1	10.9	19.5	0.8	-2.3	1.7	2.1	-3.7	-4.0	-3.8	-3.9	-1.9	-4.4	-4.4	-4.0
Blood White Count	2.5	18.4	50.8	-4.0	-6.3	3.8	6.3	4.1	-0.2	-4.5	-3.9	-7.1	-0.1	-0.8	-2.8
Heel T-Score	0.3	2.3	9.6	-0.5	1.8	-0.9	-0.7	0.6	2.0	1.0	1.2	-0.5	3.1	1.3	2.0
BMI	0.2	0.9	4.5	0.4	0.1	1.3	-0.4	1.1	0.7	0.0	0.4	-0.4	2.1	0.6	1.4
Height	3.2	61.5	112.4	7.5	10.3	0.7	-10.1	-0.1	6.2	9.8	8.8	10.6	5.1	7.3	8.4
Waist Hip Ratio (WHR)	0.4	1.8	4.7	0.5	-2.2	-2.0	2.1	-0.1	-0.7	-1.0	-1.3	-1.6	-0.8	-1.0	-1.1
Systolic Blood Pressure	9.5	47.5	80.6	2.9	6.5	4.0	-6.2	4.8	8.4	7.3	8.3	4.0	8.8	9.0	8.7
Smoking Status	3.7	8.7	16.5	-2.0	-4.0	0.6	4.1	-0.3	-2.4	-3.5	-3.6	-3.9	-2.3	-2.7	-3.1
Allergy or Eczema	3.1	8.2	12.8	-1.6	-2.3	-2.3	2.4	-3.1	-3.1	-3.0	-3.4	-2.3	-3.3	-3.6	-3.3
Cardiovascular Disease	11.9	39.4	66.1	3.3	6.2	1.7	-5.6	5.8	7.2	6.7	7.4	4.0	8.1	8.0	7.5
Hypothyroidism (self reported)	0.4	0.9	3.0	-1.7	-1.6	0.6	1.2	-0.4	-0.4	0.7	-0.9	-0.4	-0.6	0.3	-0.7
Respiratory disease	1.6	3.5	10.2	-1.6	-1.6	-1.0	1.4	-3.2	-1.8	-1.5	-1.8	-0.7	-2.4	-2.4	-1.8
Type 2 Diabetes (T2D) (2018)	1.1	2.1	5.2	0.5	1.6	-0.6	-1.4	0.5	1.7	1.4	1.5	0.5	2.3	1.7	2.1
Lung FEV1/FVC ratio	4.7	24.0	36.5	4.0	4.5	4.0	-4.5	4.1	5.9	5.1	5.1	3.5	5.7	5.5	6.0
Lung FVC	0.9	4.5	14.7	2.2	0.6	3.8	-1.0	2.4	2.9	2.5	1.4	1.4	1.1	2.6	1.0
Neuroticism	0.5	1.1	1.8	-0.9	-1.2	1.2	1.3	0.1	-0.7	-1.1	-1.0	-1.3	-0.6	-1.0	-1.4
Chronotype (morning person)	1.7	4.0	7.9	0.6	1.8	1.7	-1.5	2.3	2.5	1.7	2.0	0.9	2.8	2.4	2.6
Hair Pigment	0.3	7.2	15.9	3.6	1.3	1.8	-1.3	3.8	3.7	3.4	2.1	1.9	0.4	4.0	1.9
Tanning	2.2	26.5	41.5	-3.4	-5.1	-1.4	5.0	-2.5	-6.4	-6.3	-6.4	-4.7	-5.1	-6.2	-6.2
Hand grip strength (left)	0.2	0.6	2.2	1.1	0.6	0.6	-0.7	-1.5	-0.1	0.6	0.6	1.0	0.7	-0.1	0.2
Number of treatments/medications taken	0.3	0.5	2.3	-0.2	0.4	0.1	-0.6	0.4	0.5	0.3	0.9	0.1	1.3	0.6	1.5
Average weekly spirits intake	0.2	0.3	1.5	1.2	0.2	0.2	-0.1	0.3	0.1	0.5	1.0	0.1	0.7	0.3	0.3
Sensitivity / hurt feelings	0.2	0.3	0.8	0.4	0.9	0.3	-0.6	0.1	0.8	0.7	0.4	0.3	0.5	0.5	0.6
Frequency of depressed mood in last 2 weeks	0.9	1.2	5.7	-0.6	-1.6	-1.1	1.3	2.4	0.1	-0.5	0.1	-1.5	0.8	0.2	-0.3
Hearing difficulty/problems: Yes	0.2	0.3	0.8	0.9	0.4	-0.8	-0.6	-0.4	0.5	0.2	-0.6	0.3	-0.5	0.1	0.1
Relative age of first facial hair	1.3	2.7	10.2	0.5	1.3	-3.2	-1.4	-1.3	-0.8	1.8	1.6	3.0	-1.2	0.2	0.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.1	-0.3	-0.8	0.0	1.0	-0.6	-0.4	-1.4	-1.0	-1.2	-0.6	-1.1	-0.4
Ever used hormone-replacement therapy (HRT)	2.5	3.1	6.7	-1.8	-2.1	-2.1	1.9	0.7	-1.4	-2.6	-1.3	-2.6	-0.7	-1.7	-1.3
Ever had hysterectomy (womb removed)	1.9	2.1	5.6	-0.3	-0.9	-0.8	1.0	-1.2	-2.0	-2.4	-1.4	-1.6	-1.4	-2.1	-1.2
Systolic blood pressure, automated reading	10.8	31.4	56.1	2.7	5.8	2.9	-5.8	3.1	6.6	5.9	6.5	3.8	6.9	6.8	7.5
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	5.7	0.9	1.3	1.0	-1.4	0.6	1.9	2.0	0.9	1.1	1.0	2.4	1.7
Angina	0.6	0.7	2.3	1.2	1.0	-0.9	-0.9	0.4	-0.3	0.7	1.2	1.5	0.0	-0.1	0.4
Medication for hormone replacement therapy	0.9	1.0	2.4	-0.7	-1.6	-1.5	1.4	-0.3	-1.0	-0.8	-0.7	-1.1	-0.5	-0.9	-0.9
Vitamin and mineral supplements	1.5	2.0	4.9	1.0	1.4	2.2	-1.8	-0.1	1.0	2.0	0.7	1.6	1.0	1.6	1.0
Supplements: Zinc	1.2	1.4	7.3	-1.5	0.5	-2.7	0.0	1.3	0.3	-0.3	1.2	-0.9	1.5	0.2	0.4
Medication: Co-codamol	0.9	1.0	1.7	-0.3	-1.1	0.2	1.1	-1.0	-1.2	-1.3	-1.2	-1.0	-1.2	-1.2	-0.8
Medication: Metformin	0.6	0.8	2.6	0.6	1.0	1.6	-1.0	-0.3	1.0	0.9	0.2	0.9	0.7	0.8	1.0
Diabetes (father)	0.5	0.6	1.5	-1.1	0.3	0.4	-0.7	0.8	0.7	0.7	0.6	0.1	1.2	1.1	0.9
Diabetes (mother)	0.3	0.4	1.3	-1.1	-0.2	0.3	0.2	0.8	0.8	-0.3	-0.5	-1.0	1.0	0.2	0.3
Severe depression (siblings)	0.3	0.3	1.0	-0.6	-1.0	0.7	0.5	0.5	0.6	-0.2	-0.2	-0.7	-0.2	0.3	0.1
Pack years adult smoking proportion	0.5	0.8	1.5	0.8	-1.0	-0.4	1.2	1.1	-0.6	-0.9	-0.9	-1.1	-0.2	-1.0	-0.7
Impedance of leg (right)	1.0	5.0	10.8	-2.7	-2.1	-3.3	2.7	-1.6	-1.3	-1.2	-2.0	-2.4	-2.3	-1.5	-2.7
Leg fat-free mass (left)	3.0	15.6	29.2	4.2	5.0	2.6	-5.4	0.8	2.7	3.7	4.3	4.7	3.7	3.1	4.8
Trunk fat percentage	0.4	1.5	2.5	1.5	1.5	1.5	-1.6	-1.3	0.9	1.2	0.4	1.1	0.7	0.6	1.4
Hand grip strength (right)	0.4	1.2	2.2	1.3	1.2	1.2	-1.1	-0.8	0.4	1.0	1.5	1.5	1.2	0.2	0.9
Townsend deprivation index at recruitment	0.1	0.2	0.6	0.3	0.0	-0.2	-0.2	0.5	0.5	0.2	0.4	0.1	0.2	0.6	0.8
Current tobacco smoking	3.7	6.0	12.6	-1.6	-3.5	0.7	3.5	0.6	-1.7	-2.7	-3.0	-3.3	-1.9	-1.8	-2.7
Average weekly fortified wine intake	0.8	0.9	2.4	1.3	1.2	0.7	-1.4	-0.4	-0.0	1.1	0.0	1.5	-0.2	0.5	1.2
Maternal smoking around birth	1.4	2.0	6.0	-1.0	-1.6	0.5	1.7	0.4	-0.7	-1.7	-2.3	-2.4	-0.5	-1.1	-1.1
Fed-up feelings	0.3	0.6	1.7	-1.1	-0.9	0.8	0.4	1.3	0.3	-0.0	0.4	-1.0	1.1	0.0	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.9	-0.3	-2.0	0.1	1.9	0.3	-1.3	-1.2	-0.8	-1.5	-1.2	-1.2	-1.8
Relative age voice broke	0.6	1.0	8.8	-0.2	0.6	-3.0	-0.2	-0.1	0.4	0.8	0.8	0.8	-0.2	0.4	0.3
Taking other prescription medications	0.2	0.3	1.3	0.5	-0.1	-1.0	-0.1	-1.1	0.4	0.2	-0.7	0.4	-0.4	-0.2	0.5
Age when periods started (menarche)	1.8	4.3	13.4	3.0	2.4	-2.2	-2.2	-2.4	-0.2	2.1	1.3	3.7	-1.2	-0.3	1.0
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	6.8	0.1	0.3	2.6	-0.7	0.9	1.5	0.6	1.0	0.1	1.3	1.6	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	4.6	1.4	1.4	-0.0	-1.1	-0.0	1.6	2.1	0.2	1.3	1.4	1.7	1.2
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	2.0	0.5	1.1	-0.7	-0.6	0.9	0.9	1.0	0.8	0.4	1.1	1.4	0.8
Qualifications: CSEs or equivalent	0.4	0.5	1.8	-0.5	-0.7	1.0	0.8	0.2	-1.3	-1.0	-0.2	-0.4	-0.5	-0.7	-0.4
Serious illness, injury or assault to yourself	0.5	0.6	2.0	0.6	0.0	-0.5	0.6	-1.4	-0.9	-0.6	-0.6	-0.6	-1.4	-0.5	-0.6
High blood pressure	9.7	27.0	46.6	3.3	5.9	3.0	-5.5	3.6	5.5	5.0	5.6	3.4	6.8	6.0	6.7
Hayfever, allergic rhinitis or eczema	1.5	3.2	6.3	-0.3	-1.4	-1.1	1.3	-2.4	-2.1	-1.7	-2.1	-0.8	-2.4	-2.5	-2.0
Multivitamins +/- minerals	2.9	3.7	5.7	-1.1	-1.9	-1.4	2.2	-0.9	-2.0	-2.4	-1.8	-1.8	-2.1	-2.3	-2.2
Stomach or abdominal pain in last month	0.3	0.4	1.2	0.9	0.5	-1.1	-0.1	-0.8	-0.9	-0.6	-0.0	-0.5	-0.3	-0.7	0.1
Supplements: Glucosamine	9.1	11.8	20.1	-2.1	-3.2	-3.4	3.3	-2.1	-4.1	-4.1	-3.8	-3.1	-3.0	-4.5	-3.7
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.2	1.5	1.4	1.0	-1.4	0.1	0.6	1.1	1.5	1.4	0.5	0.8	1.2
Medication: Atenolol	1.2	1.5	3.5	1.8	1.5	1.9	-1.2	-0.8	0.7	0.9	0.6	1.2	1.0	0.7	1.6
Medication: Levothyroxine sodium	0.5	0.9	4.9	-2.2	-1.7	0.3	1.1	0.2	0.6	0.5	-0.1	-0.9	0.3	0.6	0.1
Sitting height	1.6	11.1	18.9	3.5	4.3	1.4	-4.3	0.7	2.3	3.6	4.2	4.3	2.6	2.8	3.3
Chronic bronchitis/emphysema (father)	0.2	0.2	1.0	-0.3	-0.3	-1.0	-0.1	0.6	0.0	-0.5	0.4	-0.0	-0.0	-0.6	-0.2
High blood pressure (mother)	5.0	7.0	12.1	1.4	2.6	1.6	-2.3	2.3	3.5	2.6	3.0	1.6	3.4	3.0	3.2
Body mass index (BMI)	0.4	1.7	7.5	1.3	0.8	2.7	-1.3	0.7	0.9	0.3	0.7	0.2	2.0	0.7	1.7
Impedance of leg (left)	1.0	5.0	8.7	-2.9	-2.5	-2.7	3.0	-1.3	-1.2	-1.1	-1.9	-2.4	-2.4	-1.3	-2.8
Leg predicted mass (left)	2.9	15.4	28.9	4.2	5.0	2.7	-5.4	0.8	2.7	3.6	4.3	4.7	3.7	3.0	4.8
Trunk fat mass	0.8	3.5	6.6	2.2	2.4	2.0	-2.6	-0.9	1.4	1.8	1.4	2.0	1.5	1.2	2.3
Waist circumference	0.9	3.4	6.8	2.2	1.9	1.3	-2.5	-0.2	1.5	1.8	1.6	1.9	2.0	1.3	2.6
Number of incorrect matches in round	0.2	0.3	1.3	0.9	0.3	0.3	-0.6	0.1	-0.1	0.7	0.4	1.1	-0.0	0.0	0.4
Past tobacco smoking	0.8	1.5	4.2	1.3	1.4	-0.3	-1.6	0.6	0.8	1.6	1.3	2.1	0.3	1.0	0.9
Alcohol usually taken with meals	0.6	0.9	8.3	-0.0	1.1	-2.9	-0.3	0.2	-0.1	0.2	0.8	0.3	0.5	0.2	0.5
Nervous feelings	0.6	1.2	6.0	-1.5	-1.1	-2.4	1.4	0.2	0.4	-0.3	-0.8	-1.1	-0.2	-0.3	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.0	1.0	-0.1	1.0	0.0	0.5	0.5	0.5	0.8	0.3	0.0	0.4	0.1
Hearing difficulty/problems with background noise	1.4	2.2	5.7	0.7	-1.1	-0.3	1.5	-1.2	-1.4	-1.2	-2.0	-0.8	-2.4	-1.6	-2.2
Hair/balding pattern: Pattern 2	0.4	0.5	1.1	1.0	-0.3	0.7	0.2	-1.0	-1.1	0.1	-0.2	0.7	-0.9	-0.8	-0.6
Had menopause	1.3	1.6	4.3	-0.0	-1.2	-0.5	0.8	-1.6	-1.5	-1.2	-0.9	-0.4	-2.1	-1.9	-1.3
Had other major operations	9.5	11.6	17.3	-1.7	-4.0	-0.7	3.7	-1.9	-3.7	-4.0	-4.2	-3.4	-3.8	-3.9	-3.9
Forced vital capacity (FVC)	2.1	8.0	15.8	2.2	2.3	2.8	-2.7	2.0	3.2	4.0	3.1	2.9	2.6	3.3	2.2
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	6.3	1.7	1.8	0.2	-1.4	0.5	1.7	2.5	0.5	1.6	1.7	1.8	1.2
Ever unenthusiastic/disinterested for a whole week	2.7	3.3	7.8	-2.3	-2.8	-0.5	2.5	1.9	-0.5	-1.6	-2.1	-2.8	-0.1	-0.8	-1.4
Qualifications: None of the above	0.6	1.3	7.2	2.7	0.9	1.1	-1.4	-0.6	0.4	0.6	-0.5	1.5	-1.0	0.1	0.3
Financial difficulties in last 2 years	0.7	1.0	2.4	-0.7	-1.5	0.3	1.1	0.5	-0.7	-1.5	-0.8	-1.5	-0.4	-1.0	-0.9
Mouth/teeth dental problems	0.3	0.4	2.6	1.6	0.9	0.7	-0.4	0.2	0.3	0.2	0.0	0.7	-0.1	-0.1	0.1
Heart attack	0.8	1.0	3.4	-0.8	0.6	0.0	-0.5	1.3	1.0	0.6	1.4	-0.1	1.9	0.8	1.2
Allergy	1.9	4.5	7.9	1.2	2.1	2.0	-1.8	2.8	2.3	1.9	2.1	1.1	2.5	2.7	2.1
Pain all over the body in last month	0.9	1.0	3.1	0.8	1.8	0.0	-1.4	-0.7	0.7	1.0	1.5	1.0	-0.0	0.7	0.6
Diabetes (self-reported)	0.5	0.8	2.4	0.3	0.4	0.2	-0.3	0.3	1.4	1.0	-0.1	-0.4	1.6	1.4	1.4
Hayfever/allergic rhinitis (self-reported)	2.6	3.5	6.5	-0.8	-2.0	-0.9	2.0	-1.6	-2.0	-1.9	-2.4	-1.4	-2.0	-2.5	-1.9
Medication: Ramipril	0.5	0.6	2.5	0.0	0.3	-0.2	-0.7	1.6	0.0	0.3	1.1	0.4	1.4	0.4	0.8
Medication: Simvastatin	1.4	2.1	3.6	0.4	1.7	1.2	-1.9	0.2	1.6	1.6	1.2	1.1	1.7	1.6	1.8
Fluid intelligence score	2.1	4.5	9.1	1.1	2.3	0.2	-1.7	2.0	2.6	3.0	2.1	1.6	2.2	2.7	2.2
Illnesses of siblings	4.1	5.7	15.7	0.5	-0.7	-1.7	0.6	-3.5	-3.3	-1.7	-2.0	0.2	-4.0	-2.9	-3.2
Neuroticism score	0.2	0.4	1.0	-1.0	-0.4	0.6	0.6	0.9	0.7	-0.0	0.1	-0.9	0.4	0.2	0.1
Weight	2.1	10.3	18.9	3.6	3.9	2.9	-4.3	0.1	2.3	3.0	3.2	3.5	3.2	2.4	3.9
Impedance of arm (right)	0.4	2.0	8.8	-0.5	0.4	-3.0	0.3	-2.4	-0.6	0.8	-0.3	1.0	-2.3	-0.7	-1.1
Arm fat percentage (right)	0.2	0.8	4.4	1.0	0.7	2.1	-0.9	-0.5	0.6	0.3	-0.1	0.2	0.9	0.1	1.0
Trunk fat-free mass	2.4	13.8	24.7	3.9	4.5	2.4	-5.0	1.1	2.5	3.4	4.2	4.5	3.7	3.0	4.4
Hip circumference	2.6	11.3	19.4	3.1	3.8	2.3	-4.4	0.6	2.9	3.6	3.8	3.7	3.3	3.0	4.1
Time employed in main current job	0.4	0.5	3.6	-0.1	-1.0	1.9	0.6	-0.1	0.4	0.3	-0.2	-0.5	0.1	0.6	-0.2
Alcohol intake versus 10 years previously	0.2	0.2	0.7	0.4	0.1	-0.8	0.2	0.1	0.7	0.5	-0.7	-0.3	0.1	0.6	0.2
Father’s age at death	1.1	1.5	3.9	0.1	-0.5	-0.2	0.9	-1.8	-1.7	-1.8	0.0	-0.3	-1.4	-2.0	-1.1
Worrier / anxious feelings	3.2	6.0	12.4	-3.5	-2.9	-0.5	3.0	0.1	-1.9	-2.9	-2.5	-3.2	-1.3	-2.3	-2.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.4	-0.6	-1.6	-0.1	1.2	1.3	-0.1	-0.6	-0.5	-1.4	0.4	-0.3	-0.5
Falls in the last year	0.5	0.6	3.1	0.9	-0.6	0.3	0.4	-0.0	-0.7	-0.2	-0.8	-0.0	-1.8	-0.5	-1.3
Hair/balding pattern: Pattern 3	2.1	3.2	6.1	-2.1	-1.9	-1.6	2.1	0.1	-1.0	-1.9	-2.3	-2.5	-1.4	-1.3	-1.9
Number of live births	4.8	6.8	17.1	0.7	2.9	1.2	-2.6	2.1	2.6	1.7	3.5	1.1	4.1	2.6	3.7
Forced expiratory volume in 1-second (FEV1)	5.3	17.8	29.8	3.2	3.6	3.7	-3.9	3.3	4.8	5.5	4.5	3.9	4.5	5.1	4.1
Pulse rate	1.0	1.8	4.7	1.8	1.0	-0.7	-0.5	1.4	2.2	0.8	1.4	-0.0	1.0	1.6	1.8
Happiness	1.4	1.7	5.9	0.8	0.9	1.5	-0.6	2.4	1.9	0.7	0.8	-0.0	1.6	1.3	1.2
Noisy workplace	0.4	0.4	0.9	0.6	0.8	0.7	-0.7	-0.8	0.6	0.6	0.2	0.4	0.7	0.6	0.9
Qualifications: A levels/AS levels or equivalent	0.3	0.6	5.0	-0.6	0.4	-2.2	0.3	-0.1	-0.5	-0.2	1.0	0.2	0.8	-0.5	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.8	-0.1	0.1	0.4	-0.2	0.1	0.9	-0.1	-0.4	-0.5	0.1	0.6	0.6
Mouth/teeth dental problems: Dentures	1.2	2.0	4.2	-0.2	-1.6	-0.1	1.1	-1.7	-1.9	-1.1	-1.9	-0.7	-2.0	-1.5	-1.4
Asthma	1.4	2.8	4.9	-2.2	-2.1	-1.6	1.7	-1.5	-1.5	-1.4	-1.9	-1.4	-1.2	-1.8	-1.4
Medication: Ibuprofen (e.g. Nurofen)	3.6	4.6	9.2	-1.4	-2.4	-3.0	2.0	-1.0	-3.0	-2.1	-1.9	-1.3	-1.6	-2.7	-2.2
Medication: Cholesterol lowering	0.9	1.3	3.1	-0.0	1.2	0.2	-1.4	0.2	0.9	1.2	1.8	1.0	1.5	1.4	1.5
Depression (self-reported)	0.3	0.4	0.7	-0.8	-0.8	0.3	0.8	0.7	-0.6	-0.7	0.2	-0.8	0.2	-0.6	-0.5
Medication: Lansoprazole	1.8	2.0	5.0	-0.9	-1.5	0.3	1.5	-0.4	-1.0	-1.3	-2.2	-2.0	-1.5	-1.0	-1.9
Prospective memory result	2.5	3.1	5.9	-2.1	-2.0	-1.1	1.3	-1.5	-2.4	-1.5	-1.3	-0.8	-1.9	-1.9	-2.4
Lung cancer (father)	1.3	1.5	4.2	-2.1	-1.1	-0.3	1.4	-1.0	-1.2	-1.5	-0.8	-1.3	-0.5	-1.5	-1.2
Illnesses of mother	1.1	1.3	4.3	0.6	-1.1	0.1	0.7	-0.7	-1.9	-0.8	-0.9	0.5	-2.1	-1.3	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	6.9	22.0	36.0	4.0	4.1	3.7	-4.3	3.5	5.5	6.0	5.0	4.5	4.5	5.5	4.7
Pulse wave Arterial Stiffness index	0.3	0.3	1.4	0.8	-0.1	1.2	-0.3	0.0	0.3	-0.4	-0.3	-0.9	0.7	0.2	0.1
Impedance of arm (left)	0.5	2.2	8.5	-0.3	0.4	-2.9	0.5	-2.8	-0.6	0.7	-0.6	0.8	-2.5	-0.8	-1.1
Arm fat mass (right)	0.8	3.5	7.1	2.0	2.0	2.7	-2.3	0.0	1.6	1.4	1.4	1.5	2.2	1.3	2.5
Trunk predicted mass	2.3	13.3	23.8	3.9	4.4	2.4	-4.9	1.1	2.5	3.3	4.2	4.4	3.6	2.9	4.4
Standing height	2.8	27.7	60.7	5.3	7.1	0.6	-7.1	-1.0	3.4	6.4	6.0	7.8	2.9	4.2	5.4
Length of working week for main job	0.8	0.9	2.5	1.1	-0.7	0.8	0.4	-0.2	-0.9	0.1	-1.4	0.5	-1.6	-0.6	-1.5
Exposure to tobacco smoke at home	0.6	0.7	2.2	0.4	0.5	0.1	-0.6	0.9	1.5	1.1	0.2	0.6	0.4	1.4	0.9
Breastfed as a baby	3.1	3.8	8.8	-2.3	-2.1	-1.7	2.5	1.7	-1.1	-2.6	-1.4	-3.0	-0.4	-1.6	-1.6
Tense / ‘highly strung’	0.4	0.7	3.3	-1.0	-0.5	0.3	0.7	1.8	-0.1	-1.2	0.3	-1.2	0.3	-0.3	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	5.6	8.5	18.6	-4.3	-3.8	-2.0	3.6	0.9	-1.8	-3.6	-2.5	-4.1	-1.0	-2.3	-2.4
Hair/balding pattern: Pattern 4	0.2	0.4	1.1	0.4	1.1	-0.9	-0.5	-0.4	-0.8	-0.5	0.3	0.0	0.9	-0.7	0.3
Birth weight of first child	0.1	0.2	1.0	-1.0	0.1	-0.3	-0.2	-0.1	-0.3	-0.3	0.0	-0.2	1.0	-0.2	0.5
Peak expiratory flow (PEF)	0.4	0.9	2.6	0.5	0.7	0.6	-0.8	0.7	1.1	1.6	0.8	1.1	1.1	1.0	0.6
Pulse wave reflection index	0.8	1.0	2.4	0.0	-0.7	1.5	0.4	-0.7	-1.6	-1.2	-1.1	-0.8	-0.2	-1.4	-1.1
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.1	-0.3	-1.1	0.0	1.3	0.4	-1.3	-1.3	-1.8	-1.4	-0.7	-1.0	-1.2
Loud music exposure frequency	0.4	0.4	1.3	0.8	-0.6	-0.2	0.5	-0.2	-1.1	-0.8	0.5	-0.4	-0.6	-0.8	-0.4
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	4.5	-0.7	0.1	-2.1	0.7	-1.4	-1.4	-0.7	-0.1	-0.3	0.4	-1.5	-0.7
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	4.8	-0.9	0.4	-0.6	-0.8	1.6	1.3	1.1	2.2	0.8	1.7	1.6	1.4
Blood clot in the leg (DVT)	0.2	0.3	0.8	0.6	0.3	-0.6	-0.6	-0.7	0.2	0.1	-0.1	0.8	-0.9	-0.0	0.2
Medication: Paracetamol	0.5	0.8	3.9	0.7	0.0	-2.0	0.4	-0.1	-0.8	-1.5	-0.3	-0.8	-0.2	-1.1	0.1
Headache pain in last month	1.5	2.5	7.6	-0.7	-0.5	-1.0	0.4	2.8	2.1	1.0	0.8	-1.0	2.5	2.1	1.8
Medication for cholesterol, blood pressure or diabetes	3.1	5.1	13.2	0.7	-1.9	-0.3	1.9	-1.6	-2.5	-1.9	-3.1	-0.9	-3.6	-2.7	-3.3
Glaucoma (self-reported)	0.3	0.3	1.1	-0.1	-0.2	-0.8	0.1	-0.6	-0.3	0.2	-0.5	0.3	-1.0	-0.3	-1.1
Gout (self-reported)	5.7	7.8	12.5	1.6	2.4	3.5	-2.9	1.6	3.5	3.0	2.9	2.7	2.5	3.2	3.0
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	7.5	-2.7	-2.0	-0.3	1.7	-0.2	-0.4	-0.1	-0.9	-1.3	-0.1	0.0	-0.4
Medication: Amlodipine	3.1	4.3	13.0	0.9	1.3	2.4	-1.1	2.5	2.5	1.6	1.1	0.1	3.6	2.5	2.7
Medication: Ventolin 100micrograms inhaler	7.2	9.2	19.8	-4.5	-3.9	-2.7	3.6	-1.2	-2.4	-3.3	-2.9	-3.4	-1.9	-2.6	-2.6
Birth weight	1.9	4.1	8.8	-1.8	-2.1	0.4	2.4	-1.2	-1.6	-2.6	-3.0	-2.3	-1.2	-2.4	-2.1
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.3	-0.8	-0.5	-0.4	0.5	-1.1	-0.1	0.3	-0.6	-0.3	-0.8	0.2	-0.5
High blood pressure (siblings)	9.2	13.3	27.4	0.3	1.8	3.4	-1.9	4.3	5.2	3.5	3.2	1.0	5.2	4.7	4.8
Forced vital capacity (FVC), Best measure	3.6	13.3	23.4	3.1	3.3	2.7	-3.5	2.5	4.3	4.8	4.1	3.9	3.2	4.1	3.3
Body fat percentage	0.2	0.7	2.9	1.1	0.8	1.7	-0.9	-1.1	0.7	0.5	-0.2	0.2	0.6	0.2	0.9
Leg fat percentage (right)	0.2	0.6	3.2	0.3	-0.2	1.8	0.1	-0.6	0.6	-0.5	-0.8	-1.4	0.9	-0.1	0.5
Arm fat-free mass (right)	1.8	9.4	15.8	3.2	3.4	2.6	-4.0	1.2	2.3	2.6	3.2	3.2	3.3	2.7	3.9
Exposure to tobacco smoke outside home	0.6	0.7	2.0	-0.6	-1.3	1.4	1.0	0.9	-0.6	-0.5	-0.5	-1.2	-0.0	-0.2	-0.7
Comparative body size at age 10	1.9	5.2	13.7	0.4	1.5	1.2	-1.9	3.1	2.8	1.9	2.1	0.9	3.7	2.6	2.9
Number of full brothers	0.2	0.3	1.0	0.7	0.2	1.0	-0.5	0.3	0.7	0.7	-0.3	0.2	0.4	0.4	0.4
Worry too long after embarrassment	0.2	0.3	1.1	-0.1	0.5	0.4	-0.4	0.1	0.8	1.1	0.7	0.3	0.3	0.9	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	6.3	-2.5	-2.4	0.6	1.8	1.7	-0.5	-1.4	-0.6	-1.8	-0.2	-0.5	-1.1
Wheeze or whistling in the chest in last year	2.4	4.3	11.9	-2.1	-1.8	-3.4	1.9	-1.7	-2.2	-2.2	-1.3	-2.0	-1.6	-2.3	-1.5
Number of children fathered	0.7	0.8	2.4	0.4	0.8	-1.0	-1.3	-1.3	-1.3	0.4	0.6	1.6	-0.3	-0.4	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.8	-0.3	0.5	-1.3	-0.2	0.8	0.7	-0.3	0.9	-0.1	0.9	0.2	0.6
Age at first live birth	1.3	2.2	4.9	-1.1	-1.6	-1.7	1.3	-2.0	-1.7	-0.3	-1.2	0.3	-2.2	-1.4	-1.9
Pulse wave peak to peak time	0.5	0.5	2.2	-0.4	0.7	-1.2	-0.4	-0.1	0.1	0.9	0.8	1.5	-0.4	0.2	0.4
Health satisfaction	0.4	0.6	1.3	-1.0	-0.2	-1.0	0.6	1.2	0.3	-0.3	1.0	-0.9	1.1	-0.1	0.3
Shortness of breath walking on level ground	0.4	0.5	2.2	0.9	-0.2	-0.8	0.3	-1.2	-0.4	-0.0	0.1	0.5	-1.5	-0.5	-0.4
Qualifications: College or University degree	1.4	4.3	9.1	-1.0	1.9	-2.0	-0.9	1.8	2.6	1.7	2.8	0.3	3.0	2.6	2.3
Eye problems/disorders: None of the above	0.3	0.3	1.1	0.3	0.4	1.0	-0.4	1.0	0.0	-0.3	1.0	0.2	0.4	0.0	0.2
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.7	-1.0	-0.1	1.6	0.2	0.8	1.0	-0.1	-0.3	-1.0	0.7	0.7	0.3
Emphysema/chronic bronchitis	3.0	3.4	6.2	-1.7	-2.0	-2.5	2.0	-0.7	-1.5	-1.7	-2.4	-2.1	-1.0	-1.6	-1.8
Medication for pain relief, constipation, heartburn	0.7	1.3	7.4	0.1	0.7	2.7	-0.8	0.6	1.3	1.3	0.2	0.7	0.6	1.3	0.4
Neck or shoulder pain in last month	0.3	0.4	1.4	1.2	0.2	-0.2	-0.7	0.2	-0.1	0.7	-0.1	1.2	-0.7	-0.0	-0.3
Medication: Blood pressure	3.4	6.0	17.2	-0.8	2.2	0.7	-2.1	1.8	2.5	1.7	3.2	0.8	4.1	2.7	3.8
Angina (self-reported)	0.4	0.5	1.6	1.3	0.7	-0.9	-0.6	0.4	-0.3	0.5	0.8	1.3	-0.2	-0.2	0.2
Migraine (self-reported)	0.5	0.6	4.1	-1.1	-0.9	-2.0	0.5	-0.2	-0.4	-0.5	0.3	-0.5	0.2	-0.1	-0.2
Medication: Ibuprofen	1.7	2.1	5.7	-0.6	-1.5	-2.3	0.8	-0.9	-2.4	-1.0	-1.1	0.0	-1.3	-1.9	-1.5
Medication: Allopurinol	3.0	4.0	6.3	1.1	1.6	1.8	-2.2	1.2	2.2	2.4	2.5	2.2	1.5	2.5	2.1
Medication: Omeprazole	0.3	0.4	0.9	-0.1	0.3	0.5	-0.3	0.4	0.9	0.4	0.9	-0.1	0.6	0.9	0.9
Medication: Seretide 50 evohaler	4.4	5.1	10.7	-3.3	-2.8	-1.3	2.8	0.0	-1.6	-2.1	-3.1	-2.7	-0.8	-2.1	-2.2
Mean time to correctly identify matches	1.8	3.4	7.6	-0.4	-1.6	-0.8	1.1	-1.1	-2.5	-1.9	-2.0	-0.4	-2.8	-2.7	-2.5
Heart disease (mother)	0.2	0.3	0.8	-0.8	-0.0	0.1	0.4	-0.9	-0.0	-0.6	-0.4	-0.9	-0.4	-0.3	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.3	-1.2	-1.1	-0.4	1.5	-0.7	-1.2	-1.4	-1.2	-1.4	-0.9	-1.3	-0.9
Whole body fat mass	0.7	3.0	5.3	2.0	2.0	2.1	-2.3	-0.5	1.4	1.5	1.3	1.6	1.7	1.2	2.3
Leg fat mass (right)	0.6	2.3	5.8	1.7	1.5	2.4	-1.8	-0.2	1.5	1.0	1.1	0.8	1.8	1.1	2.0
Arm predicted mass (right)	2.0	10.1	17.6	3.4	3.6	2.5	-4.2	1.2	2.3	2.9	3.4	3.4	3.3	2.8	3.9
Pulse rate, automated reading	0.3	0.9	2.8	-0.0	-1.1	-0.8	1.1	1.2	1.7	-0.1	-0.4	-1.5	-0.3	0.7	0.3
Alcohol intake frequency.	0.1	0.2	1.3	0.9	0.3	-1.1	0.1	0.4	0.3	-0.0	-0.3	-0.4	0.3	0.2	0.3
Comparative height size at age 10	1.0	5.4	10.5	2.5	2.6	2.2	-3.2	-0.6	1.7	2.8	2.3	3.0	1.4	2.2	2.3
Number of full sisters	6.4	7.8	15.1	1.0	2.2	1.6	-2.4	3.0	3.0	2.7	3.9	1.8	3.8	3.1	3.6
Suffer from ‘nerves’	0.7	1.1	2.9	-1.7	-0.7	-1.1	1.0	-0.9	-1.4	-1.1	-0.1	-0.5	-0.8	-1.5	-0.9
Overall health rating	0.6	1.4	2.8	0.7	0.7	1.1	-0.9	1.5	1.7	0.7	1.4	0.0	1.5	1.2	1.6
Chest pain or discomfort	0.7	1.0	2.7	-0.8	0.3	-1.6	-0.2	1.2	1.1	0.6	0.5	-0.7	1.3	1.3	1.1
Had major operations	0.6	0.7	3.1	0.7	-0.3	1.8	0.4	0.0	-0.8	-1.0	-0.4	-0.7	-0.9	-0.6	-1.0
Age at last live birth	1.0	1.5	3.2	-1.8	-1.7	-1.5	1.3	-0.7	-1.3	-0.9	-0.4	-0.9	-0.7	-1.1	-1.3
Family relationship satisfaction	0.5	0.6	3.1	0.1	0.6	0.5	-0.3	1.7	0.8	-0.0	0.8	-0.1	1.4	0.2	0.7
Leg pain on walking	2.7	3.4	6.2	-0.6	-1.7	-0.7	1.7	-2.4	-2.3	-2.0	-1.8	-1.0	-2.5	-2.4	-1.9
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.9	-0.3	0.4	1.4	-0.9	-0.1	0.8	0.6	0.6	0.0	1.3	1.1	1.3
Commuting to job workplace: Car/motor vehicle	3.0	3.4	6.4	-2.3	-1.9	0.4	1.3	-1.7	-2.5	-2.3	-1.8	-1.4	-1.2	-2.3	-1.9
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.9	-0.7	-0.3	-1.7	0.3	-0.7	-0.5	0.2	-0.3	0.3	-0.9	-0.6	-0.8
Medication: Aspirin	1.2	1.5	4.7	1.1	1.4	0.0	-1.4	0.3	0.7	1.4	2.2	1.1	1.2	1.1	1.4
Supplements: Vitamin C	0.3	0.3	1.3	0.8	0.5	-1.0	0.2	1.1	0.2	-0.3	0.4	-0.2	0.6	-0.2	0.3
Knee pain experienced in last month	0.9	1.3	3.1	-1.0	-1.3	0.2	1.1	0.4	-1.7	-1.8	-0.5	-1.5	-0.8	-1.0	-1.3
Hypertension (Self-reported)	8.1	22.5	40.2	2.9	5.3	2.4	-4.9	3.5	5.2	4.6	5.0	3.0	6.3	5.6	6.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.8	-0.3	-0.6	1.4	0.3	1.2	0.9	0.1	0.3	-0.8	1.4	0.9	0.7
Illnesses of father: Heart disease	2.7	3.7	6.7	1.9	2.1	0.9	-2.2	0.6	1.9	2.6	2.4	2.2	0.8	2.3	1.8
Illnesses of siblings: Diabetes	0.9	1.1	3.2	-0.7	-0.0	-0.0	-0.2	1.8	1.6	0.7	-0.0	-0.3	1.6	1.4	1.4
Smoking status: Previous	0.2	0.3	1.7	-0.7	-0.1	0.2	0.4	-1.3	-0.2	-0.7	-0.3	-0.6	-0.1	-0.6	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	4.0	8.3	15.2	2.0	2.6	1.2	-2.8	1.9	3.1	3.9	3.2	3.1	2.5	3.6	3.5
Whole body fat-free mass	2.6	14.7	26.8	4.1	4.7	2.7	-5.2	1.0	2.6	3.5	4.3	4.6	3.7	3.0	4.6
Leg fat-free mass (right)	3.0	16.0	29.3	4.3	4.9	3.0	-5.4	1.0	2.7	3.8	4.4	5.0	3.5	3.1	4.7
Arm fat percentage (left)	0.2	0.7	4.1	1.0	0.6	2.0	-0.7	-0.7	0.4	0.1	-0.3	0.0	0.7	-0.1	0.9
Average weekly red wine intake	1.2	1.8	9.7	-1.2	-0.4	-3.1	0.8	-0.3	-1.5	-1.4	-0.1	-0.7	-0.7	-1.3	-1.4
Handedness (chirality/laterality): Left-handed	0.2	0.3	2.6	-0.2	0.0	1.6	-0.1	-0.4	0.2	0.4	-0.5	0.1	0.3	0.1	-0.0
Mood swings	0.8	1.5	3.0	1.0	0.6	1.4	-0.6	1.7	1.7	1.6	0.8	0.5	1.3	1.5	1.0
Loneliness, isolation	0.7	1.0	1.9	1.4	0.8	-0.4	-1.0	0.9	0.7	1.2	1.1	1.2	0.8	0.9	1.4
Long-standing illness, disability or infirmity	0.6	0.9	2.1	-1.5	-1.4	-1.2	0.9	0.8	-0.2	-0.6	-0.6	-1.5	0.4	-0.2	-0.2
Ever had bowel cancer screening	0.5	0.5	3.6	1.0	0.3	0.1	-0.0	-1.9	-0.0	-0.0	-0.3	0.6	-1.0	-0.6	0.2
Diabetes diagnosed by doctor	0.2	0.4	1.1	-0.3	0.2	-0.1	-0.2	-0.8	0.5	0.4	-0.3	-0.6	1.1	0.7	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.5	0.4	1.0	0.9	-0.6	0.1	0.9	-0.4	0.9	-0.2	0.9	-0.0	1.2
Friendships satisfaction	6.1	7.5	12.5	2.6	2.6	1.2	-2.2	3.0	3.5	2.7	2.8	1.9	3.1	3.2	3.2
Qualifications: nursing, teaching	0.9	1.4	5.0	-1.3	-1.1	-2.2	1.3	-0.7	-1.1	-0.8	-0.9	-1.0	-0.7	-0.9	-1.1
Commuting to job workplace: Walk	4.3	4.6	12.2	1.4	1.6	0.1	-1.0	2.2	3.5	2.5	2.5	0.9	2.6	2.7	2.4
Eye problems/disorders: Cataract	1.7	2.0	4.0	-1.6	-1.6	-1.4	1.3	-1.3	-1.3	-1.1	-2.0	-1.0	-1.1	-1.5	-1.5
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	4.3	-0.6	0.8	-2.1	-0.2	0.4	0.8	0.6	0.3	-0.2	0.9	0.9	0.7
Medication for cholesterol	3.0	4.6	7.3	-1.9	-2.3	-1.3	2.0	-1.1	-2.2	-2.6	-2.0	-1.5	-2.6	-2.6	-2.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.5	1.1	0.0	-1.2	-0.2	0.0	-0.1	0.3	0.5	0.8	-0.3	-0.0	-0.1
Back pain experienced in last month	0.7	1.0	3.2	0.5	0.5	-0.7	-0.9	0.5	0.6	0.9	1.3	0.4	1.8	0.9	1.5
Mineral and other dietary supplements	3.4	4.6	9.0	1.6	1.0	3.0	-1.3	2.4	2.6	2.6	2.1	1.5	2.2	2.8	1.7
Breast cancer (self-reported)	1.8	2.1	9.3	1.7	-0.5	-0.5	-0.3	-1.6	-1.3	-0.2	-1.7	1.2	-3.0	-1.2	-1.4
Asthma (self-reported)	1.5	3.0	5.6	-2.4	-2.2	-1.2	1.7	-1.7	-1.4	-1.4	-2.0	-1.6	-1.4	-1.8	-1.5
Osteoporosis (self-reported)	1.3	1.6	3.3	-0.7	-1.8	-1.6	1.5	-0.4	-1.4	-0.7	-1.2	-0.4	-1.7	-1.2	-1.6
Osteoarthritis (self-reported)	0.7	0.9	3.8	-0.2	0.5	-1.0	-0.5	-1.9	-1.4	-1.0	0.4	0.1	-0.7	-1.5	-0.5
Medication: Aspirin	1.4	1.8	3.9	1.3	1.6	0.2	-1.7	0.4	0.9	1.6	2.0	1.5	1.0	1.3	1.5
Medication: Gliclazide	0.6	0.6	1.8	0.8	0.7	1.4	-1.0	0.6	1.1	0.5	-0.2	0.2	0.9	0.6	0.8
Illnesses of father: None of the above (group 1)	2.0	2.5	4.8	-0.7	-0.8	-2.2	1.1	-2.0	-2.2	-1.3	-1.6	-0.6	-1.7	-1.9	-1.7
Smoking status: Current	3.5	5.6	12.6	-1.5	-3.5	0.4	3.5	0.6	-1.6	-2.6	-2.9	-3.2	-1.7	-1.8	-2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.6	9.8	13.4	3.6	2.5	3.4	-2.8	2.2	3.3	3.7	3.6	3.1	2.5	3.3	3.1
Whole body water mass	2.5	14.4	26.0	4.0	4.5	2.8	-5.1	1.1	2.6	3.5	4.2	4.5	3.7	3.1	4.6
Leg predicted mass (right)	3.0	15.8	28.9	4.3	4.9	2.9	-5.4	0.9	2.7	3.8	4.4	5.0	3.5	3.1	4.7
Arm fat mass (left)	0.7	2.8	5.8	1.9	1.8	2.4	-2.1	-0.1	1.3	1.2	1.2	1.4	2.0	1.1	2.2
Number of self-reported non-cancer illnesses	1.3	2.3	5.2	0.2	1.3	0.2	-1.6	0.6	1.8	1.6	1.5	0.9	2.3	1.7	2.3
Average weekly champagne plus white wine intake	0.9	1.2	5.1	0.8	0.8	-2.3	-0.7	-1.0	-0.5	0.9	0.8	2.0	-0.7	-0.0	0.2
Miserableness	0.8	1.3	4.2	0.4	0.2	1.9	-0.1	2.0	1.6	0.7	-0.1	-0.7	1.5	1.2	0.8
Guilty feelings	0.4	0.6	2.0	-1.0	-0.5	-1.4	1.1	-0.2	0.3	-0.3	0.5	-1.0	0.9	0.1	0.4
Wears glasses or contact lenses	0.7	0.8	2.0	-1.4	0.3	-0.7	-0.1	0.5	1.4	0.4	0.9	-0.6	1.2	0.8	1.1
Ever taken oral contraceptive pill	0.3	0.4	1.8	-0.9	-0.3	-1.3	0.3	0.6	-0.2	0.3	0.0	-0.3	0.9	0.3	0.1
Hearing aid user	0.2	0.3	1.0	-0.7	-0.5	0.1	0.5	0.6	0.1	0.1	-0.6	-1.0	0.2	0.8	0.0
Mother’s age at death	0.6	0.8	1.7	-1.2	-0.6	-1.3	1.3	0.2	-0.2	-1.0	-0.8	-1.3	-0.4	-0.6	-0.6
Financial situation satisfaction	2.3	2.9	5.3	-0.7	-2.1	-1.1	2.1	-0.1	-2.2	-1.7	-1.4	-1.2	-1.9	-1.9	-2.3
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.5	-1.2	-0.5	0.1	0.4	0.4	0.8	-0.2	-0.5	-1.1	0.4	0.3	0.4
Commuting to job workplace: Public transport	1.4	1.7	3.4	1.1	1.8	-1.6	-1.1	0.5	1.4	1.3	1.4	0.8	1.2	1.2	1.7
Eye problems/disorders: Glaucoma	0.7	0.8	2.4	0.2	-0.8	-0.1	0.6	-1.1	-0.9	-0.1	-0.8	0.2	-1.5	-1.0	-1.5
Medication: Blood pressure	5.4	10.3	15.7	2.9	3.9	1.8	-3.5	1.8	3.4	3.5	2.9	2.3	3.7	3.7	4.0
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.3	0.6	0.5	0.5	-0.5	-1.1	-1.0	-0.2	-0.4	0.1	-0.4	-0.6	0.3
Supplements: Fish oil (including cod liver oil)	1.3	1.7	4.1	-0.4	-0.5	-1.6	0.8	-1.1	-1.6	-2.0	-1.3	-1.1	-1.4	-1.8	-1.0
High cholesterol (Self-reported)	2.6	4.5	9.6	-0.5	1.7	0.4	-1.6	2.4	3.1	1.7	2.6	0.4	2.9	2.9	2.6
Medication: Bendroflumethiazide	4.9	7.4	13.1	1.9	3.3	2.0	-2.3	2.4	3.6	1.9	2.8	0.9	3.6	2.9	3.5
Medication: Paracetamol	0.3	0.5	1.7	1.1	0.6	-1.3	-0.4	-0.3	-0.6	-0.7	0.1	0.3	-0.5	-0.8	0.2
Medication: Lisinopril	7.4	9.6	19.1	0.8	2.2	1.0	-2.4	2.6	4.0	3.3	3.4	1.2	4.4	4.3	4.2
Medication: Atorvastatin	2.2	2.7	5.3	0.8	1.2	1.2	-1.1	2.2	1.9	1.3	2.3	0.8	2.2	1.7	1.9
Illnesses of father: High blood pressure	5.9	7.3	13.7	2.2	2.3	3.7	-2.3	3.1	2.6	2.4	2.2	1.2	2.8	3.6	2.9
Alcohol drinker status: Never	0.4	0.5	1.7	0.4	-0.2	-1.3	0.4	0.2	-0.5	-1.1	-0.7	-0.5	-0.7	-1.1	-0.5
Ever smoked	2.5	4.4	10.4	-2.3	-2.6	0.2	3.0	-0.0	-1.6	-2.5	-2.5	-3.2	-0.6	-1.6	-1.9
Basal metabolic rate	2.6	14.5	26.4	4.1	4.6	2.9	-5.1	0.9	2.7	3.5	4.1	4.4	3.8	3.0	4.6
Leg fat percentage (left)	0.2	0.7	5.1	0.2	-0.4	2.2	0.1	-0.2	0.8	-0.3	-0.6	-1.2	0.9	0.1	0.4
Arm fat-free mass (left)	2.1	10.6	18.9	3.3	3.6	2.8	-4.3	1.4	2.5	2.9	3.4	3.4	3.5	2.9	4.0
Number of operations (self-reported)	5.5	8.2	15.0	-1.0	-2.8	-0.1	2.4	-2.1	-3.9	-3.6	-2.9	-2.6	-3.3	-3.6	-3.6
Average weekly beer plus cider intake	0.6	0.9	2.7	-0.3	-1.1	0.4	1.3	0.1	-0.7	-1.2	-1.6	-1.2	-0.7	-0.7	-0.9
Irritability	0.4	0.7	2.0	-0.6	-0.2	1.3	0.1	1.4	1.2	0.0	0.6	-0.7	1.2	0.9	0.5
Risk taking	0.2	0.2	1.3	-0.4	-0.5	1.2	0.6	0.6	0.0	-0.1	0.4	0.1	0.2	0.1	0.0
Ever had prostate specific antigen (PSA) test	0.3	0.4	2.6	-1.0	-0.3	-1.6	0.5	0.4	0.1	-0.5	-0.2	-0.5	0.3	-0.2	-0.4
Fractured/broken bones in last 5 years	0.1	0.2	1.1	-0.1	-0.2	0.1	-0.0	0.6	-0.2	0.1	0.3	0.4	-1.1	0.1	-0.4
Age started oral contraceptive pill	0.6	0.7	1.4	-0.5	-0.4	-0.5	0.6	-1.2	-0.8	-1.2	-0.8	-0.9	-1.0	-1.1	-0.5
Diastolic blood pressure, automated reading	12.9	40.1	68.7	4.0	6.4	3.7	-6.2	4.3	8.2	6.7	6.6	4.2	7.1	7.9	8.3
Ever depressed for a whole week	2.4	2.9	9.3	-2.1	-2.2	-1.3	2.4	1.4	-0.2	-1.7	-1.8	-3.0	0.2	-0.5	-0.8
Unable to work because of sickness or disability	0.9	1.1	2.2	-0.3	-1.3	-0.3	1.2	-0.8	-1.2	-1.4	-0.7	-1.0	-1.5	-1.4	-1.0
Commuting to job workplace: Cycle	0.3	0.3	1.3	1.1	0.4	0.0	-0.2	-0.4	0.6	0.8	-0.0	0.7	0.1	0.8	0.4
Myopia	0.5	0.7	3.2	-1.8	-0.7	0.0	0.9	1.0	0.4	-0.7	0.3	-1.4	0.7	0.1	-0.2
Vascular/heart problems diagnosed by doctor	8.9	24.3	45.6	-2.8	-5.4	-2.5	5.1	-4.0	-5.2	-4.7	-5.5	-3.1	-6.8	-5.6	-6.3
Cholesterol lowering medication	4.1	6.0	9.8	1.5	2.5	1.2	-2.2	2.4	3.1	2.6	2.3	1.6	3.1	2.8	3.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	3.5	-0.1	0.3	1.9	-0.1	0.6	0.6	-0.2	0.5	-0.6	0.6	0.5	0.6
Pain experienced in last month	0.5	0.8	1.7	1.0	1.2	1.1	-1.1	0.6	0.7	0.8	0.9	1.3	0.5	0.7	0.6
Supplements: Calcium	0.2	0.3	2.1	-0.4	0.0	-1.4	-0.2	0.2	0.1	-0.4	0.1	-0.2	-0.3	-0.1	0.6
Basal cell carcinoma (self-reported)	1.0	1.2	2.5	1.5	1.1	-0.4	-1.2	-0.7	0.1	1.6	1.3	1.6	0.6	0.7	1.0
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.7	-0.8	0.6	0.0	-0.4	0.9	0.7	0.4	1.2	-0.2	1.6	0.4	0.9
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.5	0.5	0.4	-0.3	-0.7	-0.6	0.4	0.2	-0.1	0.7	-0.6	0.0	0.4
Heart disease (siblings)	0.6	0.7	1.8	0.2	0.9	0.7	-0.7	0.7	1.0	0.6	1.1	0.3	1.4	0.4	1.0
Alcohol drinker status: Previous	0.6	0.7	2.0	-0.1	0.5	0.1	-0.2	1.1	1.0	0.6	1.2	0.4	1.4	0.9	1.0
Pack years of smoking	0.3	0.5	0.9	0.7	-0.8	-0.5	0.9	1.0	-0.5	-0.6	-0.7	-0.7	-0.2	-0.9	-0.6
Impedance of whole body	0.6	3.2	9.6	-1.5	-1.0	-3.1	1.6	-2.4	-0.9	0.1	-1.3	-0.5	-2.9	-1.0	-2.2
Leg fat mass (left)	0.7	2.6	7.6	1.7	1.5	2.8	-1.8	0.0	1.6	1.2	1.2	0.9	1.9	1.2	2.1
Arm predicted mass (left)	1.8	9.4	16.1	3.1	3.2	2.6	-4.0	1.5	2.4	2.8	3.2	3.2	3.5	2.7	3.8