TWAS hub - EGR2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.081	0.033	0.0018	0.01	NA	0.023	NA	0.000	0.0560	NA	0.0064	NA	0.310
2	TCGA	Skin Cutaneous Melanoma	0.123	0.070	0.0059	0.10	0.098	0.042	NA	0.078	0.0012	0.0014	0.0280	NA	0.004

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Crohns Disease (2017)	15.2	33.4	50.4	4.0	7.1
Crohns Disease (2012)	14.4	23.2	32.2	3.8	5.7
Irritable Bowel Disease (IBD)	13.0	30.9	44.7	4.1	6.7
Seen doctor (GP) for nerves, anxiety, tension or depression	9.4	14.4	14.6	-3.8	-3.8
Blood Eosinophil Count	7.9	60.9	88.9	-5.7	-9.4
Supplements: Glucosamine	6.8	8.9	10.3	-3.2	-2.7
Ever depressed for a whole week	6.7	8.3	8.8	-2.8	-3.0
Major Depression (MDD)	5.6	6.8	8.4	-2.3	-2.9
Medication: Ventolin 100micrograms inhaler	4.9	6.3	8.6	-2.0	-2.9
Breast Cancer	4.8	11.5	19.7	-1.8	-4.4
Ever unenthusiastic/disinterested for a whole week	4.3	5.2	6.0	-2.1	-2.5
Blood White Count	4.2	31.2	42.6	-4.5	-6.5
Breast cancer (self-reported)	4.0	4.7	6.0	1.9	2.5
Ulcerative Colitis (UC)	3.9	7.4	9.5	2.3	3.1
Breastfed as a baby	3.9	4.9	9.1	-0.8	-3.0
Ever used hormone-replacement therapy (HRT)	3.7	4.7	6.9	-1.6	-2.6
Forced expiratory volume in 1-second (FEV1), Best measure	3.7	11.7	12.0	3.4	3.5
Age when periods started (menarche)	3.6	8.6	12.8	2.1	3.6
Relative age of first facial hair	3.4	7.0	12.3	1.3	3.5
Forced vital capacity (FVC), Best measure	3.2	11.9	12.7	3.6	3.3
Pain experienced in last month	3.2	5.3	10.0	3.2	0.8
Health satisfaction	3.1	4.1	5.8	-2.4	-1.5
Guilty feelings	3.1	4.7	6.8	-2.6	-1.6
Emphysema/chronic bronchitis	3.0	3.3	3.9	-2.0	-1.7
Illnesses of father: Heart disease	3.0	4.2	7.8	0.8	2.8
Alzheimer’s Disease (in father)	2.9	3.2	5.6	-2.4	-0.9
Vitamin and mineral supplements	2.9	3.9	4.5	1.8	2.1
Basal cell carcinoma (self-reported)	2.9	3.5	4.4	-2.1	1.6
Smoking Status	2.8	6.8	8.5	-2.3	-2.9
Medication: Seretide 50 evohaler	2.8	3.2	5.9	-0.7	-2.4
Schizophrenia vs Biploar Disorder	2.6	3.5	4.6	1.5	2.1
Ulcerative Colitis	2.6	3.8	3.9	2.0	1.9
Worrier / anxious feelings	2.6	4.9	5.7	-2.0	-2.4
Gout (self-reported)	2.6	3.5	5.0	2.2	1.4
Ever had stillbirth, spontaneous miscarriage or termination	2.6	2.8	3.7	1.9	-1.4
Maternal smoking around birth	2.5	3.6	4.0	-1.8	-2.0
Depression (Nagel 2018)	2.4	3.6	4.6	-2.1	-1.6
Medication: Co-codamol	2.4	2.8	4.6	-2.1	-1.0
Forced expiratory volume in 1-second (FEV1)	2.4	8.2	9.3	2.7	3.0
Ever smoked	2.4	4.1	8.0	-0.6	-2.8
Height	2.3	44.4	61.8	5.2	7.9
Standing height	2.3	22.4	34.5	3.2	5.9
Forced vital capacity (FVC)	2.2	8.4	8.6	2.9	2.9
Number of children fathered	2.2	2.4	2.8	-1.4	1.7
Wheeze or whistling in the chest in last year	2.1	3.8	3.9	-2.0	-1.9
Headache pain in last month	2.0	3.4	3.8	-2.0	-1.7
Smoking status: Current	2.0	3.1	5.1	-1.0	-2.3
Wears glasses or contact lenses	2.0	2.3	3.3	-1.8	-1.1
Unable to work because of sickness or disability	2.0	2.6	4.5	-2.1	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	4.6	-2.2	-0.6
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	3.6	-1.9	-1.1
Back pain experienced in last month	1.9	2.7	5.3	-2.3	-0.4
Mineral and other dietary supplements	1.9	2.6	3.0	1.7	1.5
Worry (Nagel 2018)	1.8	3.8	4.2	-2.1	-1.8
Medication for hormone replacement therapy	1.8	2.0	3.2	-1.8	-0.9
Current tobacco smoking	1.8	3.0	4.8	-1.1	-2.2
Ever highly irritable/argumentative for 2 days	1.8	2.2	2.7	-1.7	-1.3
Frequency of depressed mood in last 2 weeks	1.7	2.3	2.8	-1.7	-1.4
Birth weight	1.7	3.6	4.9	-1.5	-2.2
Knee pain experienced in last month	1.7	2.6	4.5	-2.1	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.5	4.7	1.5	2.2
HbA1C	1.6	1.8	3.6	-0.0	1.9
Had other major operations	1.6	1.9	3.6	-0.6	-1.9
Pain all over the body in last month	1.6	1.7	2.1	-1.1	1.5
Chronic bronchitis/emphysema (mother)	1.6	1.9	3.4	-1.9	0.6
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	3.7	0.3	-1.9
Ever had hysterectomy (womb removed)	1.5	1.7	2.8	-0.8	-1.7
Supplements: Zinc	1.5	1.6	3.1	-0.3	-1.7
Medication: Atenolol	1.5	1.9	3.6	1.9	0.4
Impedance of arm (right)	1.5	6.9	8.2	2.4	2.9
Lung cancer (father)	1.5	1.8	2.2	1.5	-1.1
Length of working week for main job	1.5	1.7	3.4	0.1	1.8
Medication: Blood pressure	1.5	2.6	3.4	-1.8	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.0	4.8	1.1	2.2
Tinnitus: Yes, now most or all of the time	1.5	1.7	2.0	-1.4	-1.2
Triglycerides	1.4	2.3	2.7	-1.4	-1.6
Financial difficulties in last 2 years	1.4	1.8	1.8	-1.3	-1.4
Impedance of arm (left)	1.4	6.4	6.9	2.4	2.6
Medication: Paracetamol	1.4	2.3	2.8	-1.4	-1.7
Medication: Allopurinol	1.4	1.9	2.8	1.0	1.7
Average weekly champagne plus white wine intake	1.4	1.9	3.8	-0.1	2.0
High blood pressure (mother)	1.3	1.9	3.7	1.9	0.1
Past tobacco smoking	1.3	2.3	3.8	0.9	2.0
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	2.6	-1.6	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.6	2.6	-0.8	-1.6
Eye problems/disorders: None of the above	1.3	1.5	2.8	1.7	-0.5
Medication for pain relief, constipation, heartburn	1.3	2.2	3.2	1.8	1.1
Medication: Gliclazide	1.3	1.5	3.0	1.7	-0.1
Multivitamins +/- minerals	1.2	1.6	1.6	-1.3	-1.2
Illnesses of siblings	1.2	1.7	3.3	0.1	1.8
Exposure to tobacco smoke outside home	1.2	1.6	2.8	-1.7	-0.6
Neck or shoulder pain in last month	1.2	1.7	3.2	0.6	1.8
Bipolar Disorder (2018)	1.1	1.7	1.8	-1.4	-1.3
Schizophrenia (2018)	1.1	2.3	2.7	1.4	-1.6
Blood Platelet Count	1.1	12.4	18.8	2.5	-4.3
Average weekly fortified wine intake	1.1	1.3	1.4	-1.2	1.1
Number of live births	1.1	1.5	1.7	1.3	-1.2
Pulse rate	1.1	1.9	3.2	1.8	-0.8
Loud music exposure frequency	1.1	1.1	1.7	-1.3	-0.8
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	2.8	-1.7	0.2
Worry too long after embarrassment	1.1	1.9	3.3	-1.8	0.7
Supplements: Vitamin C	1.1	1.3	1.5	-1.2	-1.1
Loneliness, isolation	1.1	1.5	2.1	-1.4	0.9
Eye problems/disorders: Cataract	1.1	1.3	2.2	-1.5	-0.5
Mother’s age at death	1.1	1.3	2.7	-0.0	-1.6
Commuting to job workplace: Public transport	1.1	1.4	2.7	-1.6	0.1
Myopia	1.1	1.5	2.5	-0.8	-1.6
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	3.3	-1.8	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	1.9	-0.6	-1.4
Diabetes diagnosed by doctor	1.0	1.6	2.2	-1.5	-1.0
Age started oral contraceptive pill	1.0	1.3	1.7	-1.3	-0.9
Diastolic blood pressure, automated reading	1.0	3.0	4.4	2.1	1.3
Bipolar Disorder or Schizophrenia	0.9	2.2	4.2	0.3	-2.1
Chronotype (morning person)	0.9	2.1	4.2	2.0	-0.3
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.8	-0.4	1.3
Medication: Levothyroxine sodium	0.9	1.5	2.9	-1.7	-0.4
Sitting height	0.9	6.3	8.6	2.0	2.9
Glaucoma (self-reported)	0.9	1.1	1.9	0.5	1.4
Medication: Amlodipine	0.9	1.2	1.8	-0.8	-1.3
Pulse wave peak to peak time	0.9	1.0	1.9	-0.4	1.4
Coronary Artery Disease (CAD)	0.8	0.9	1.0	1.0	-0.9
Systolic Blood Pressure	0.8	3.9	6.8	2.6	1.1
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	1.3	0.8	1.1
Number of incorrect matches in round	0.8	1.3	1.9	-0.8	1.4
Mouth/teeth dental problems	0.8	1.2	2.2	1.5	0.4
Birth weight of first child	0.8	1.4	1.5	-1.2	-1.1
Number of full brothers	0.8	1.0	1.9	1.4	0.3
Shortness of breath walking on level ground	0.8	0.9	1.4	-1.2	0.6
Medication: Ibuprofen	0.8	0.9	1.9	-1.4	0.1
Eye problems/disorders: Glaucoma	0.8	1.0	1.9	0.1	1.4
Impedance of whole body	0.8	4.2	4.4	2.0	2.1
Neuroticism (Nagel 2018)	0.7	1.6	2.3	-1.5	-0.9
BMI	0.7	4.0	4.1	-2.0	-2.0
Waist Hip Ratio (WHR)	0.7	3.0	3.3	-1.8	-1.6
Angina	0.7	0.9	1.7	-0.2	1.3
Hair/balding pattern: Pattern 2	0.7	0.9	1.1	-1.1	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	2.3	0.9	1.5
Qualifications: None of the above	0.7	1.5	2.4	0.8	1.5
Diabetes (self-reported)	0.7	1.0	1.5	-1.2	-0.8
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.1	-0.9	-1.1
Medication: Simvastatin	0.7	1.0	1.6	1.3	0.6
Hair/balding pattern: Pattern 3	0.7	1.0	1.6	-0.6	-1.3
Pulse wave Arterial Stiffness index	0.7	0.8	0.8	0.9	-0.9
Long-standing illness, disability or infirmity	0.7	1.1	2.1	-0.2	-1.5
Osteoporosis (self-reported)	0.7	0.9	1.7	-1.3	0.4
Medication: Aspirin	0.7	0.9	1.6	-0.4	1.3
Number of operations (self-reported)	0.7	1.1	1.5	-0.9	-1.2
Supplements: Calcium	0.7	0.7	0.8	-0.9	-0.8
Lupus	0.6	0.8	1.4	-0.5	-1.2
Cardiovascular Disease	0.6	2.0	2.2	1.4	1.5
Lung FVC	0.6	2.9	3.5	1.5	1.9
Diabetes (mother)	0.6	0.8	1.5	0.2	-1.2
Neuroticism score	0.6	1.2	2.1	-1.5	-0.6
Hip circumference	0.6	2.4	3.0	1.4	1.7
Falls in the last year	0.6	0.8	1.5	-0.4	1.2
Asthma	0.6	1.1	1.5	-0.8	-1.2
Tense / ‘highly strung’	0.6	1.0	1.6	-0.6	-1.3
Pulse wave reflection index	0.6	0.8	1.0	-1.0	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.6	1.3	-0.0	-1.1
Age at first live birth	0.6	1.0	2.1	0.0	1.4
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.2	-0.4	-1.1
Mean time to correctly identify matches	0.6	1.1	1.9	-1.4	0.5
Family relationship satisfaction	0.6	0.8	1.3	-0.6	-1.1
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.4	0.3	-1.2
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	0.8	-0.9	0.9
Illnesses of siblings: Diabetes	0.6	0.7	0.8	0.8	-0.9
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.5	-0.4	-1.2
Alzheimer’s Disease (in mother)	0.5	0.6	1.3	-0.1	1.1
Schizophrenia (2014)	0.5	1.1	1.8	1.3	-0.6
Neuroticism	0.5	1.3	1.9	-1.4	-0.8
Fluid intelligence score	0.5	1.0	2.0	-0.1	1.4
Depression (self-reported)	0.5	0.7	1.1	-0.5	-1.0
Illnesses of mother	0.5	0.6	1.3	-0.0	1.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.3	1.1	0.6
High blood pressure (siblings)	0.5	0.8	1.0	-0.8	-1.0
Leg fat percentage (right)	0.5	1.9	3.7	-0.1	-1.9
Angina (self-reported)	0.5	0.7	1.3	-0.3	1.1
Migraine (self-reported)	0.5	0.6	0.6	0.7	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	0.1	-1.1
Comparative height size at age 10	0.5	2.9	5.2	0.7	2.3
Age at last live birth	0.5	0.7	1.2	1.1	-0.4
Smoking status: Previous	0.5	0.7	0.9	-0.9	-0.8
Leg fat-free mass (right)	0.5	2.9	4.8	1.0	2.2
Commuting to job workplace: Walk	0.5	0.5	1.0	1.0	0.1
Asthma (self-reported)	0.5	1.1	1.5	-0.8	-1.2
Leg predicted mass (right)	0.5	2.8	4.8	0.9	2.2
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.3	-1.1	0.2
Alcohol drinker status: Previous	0.5	0.6	0.8	0.9	-0.5
Reaction Time	0.4	0.8	1.5	-0.3	1.2
Rheumatoid Arthritis	0.4	0.5	0.8	-0.9	-0.4
Number of treatments/medications taken	0.4	0.7	0.9	-0.6	-1.0
Sensitivity / hurt feelings	0.4	0.6	1.2	1.1	0.3
Systolic blood pressure, automated reading	0.4	1.1	1.2	1.1	1.0
Pack years adult smoking proportion	0.4	0.6	1.3	-0.1	-1.1
Leg fat-free mass (left)	0.4	1.9	3.3	0.7	1.8
Fed-up feelings	0.4	0.8	1.2	-1.1	-0.7
Relative age voice broke	0.4	0.6	0.7	0.7	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.6	0.7	1.3
Nervous feelings	0.4	0.7	1.0	-1.0	-0.6
Had menopause	0.4	0.5	1.0	-1.0	0.2
Father’s age at death	0.4	0.6	0.9	0.5	-0.9
Suffer from ‘nerves’	0.4	0.7	1.2	-1.1	-0.4
Medication: Aspirin	0.4	0.5	0.8	-0.5	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.9	0.2	1.0
Miserableness	0.4	0.7	0.9	-1.0	-0.6
Financial situation satisfaction	0.4	0.5	0.9	-0.9	-0.3
Medication: Blood pressure	0.4	0.8	1.2	0.7	1.1
Leg fat percentage (left)	0.4	1.5	3.0	0.2	-1.7
Average weekly beer plus cider intake	0.4	0.6	0.8	-0.7	-0.9
Irritability	0.4	0.6	0.9	-0.6	-1.0
Fractured/broken bones in last 5 years	0.4	0.5	1.0	0.1	1.0
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	0.8	0.2	-0.9
Depressed Affect (Nagel 2018)	0.3	0.6	1.0	-1.0	-0.4
Fasting Glucose	0.3	0.3	0.4	0.4	0.7
HDL Cholesterol	0.3	0.5	1.1	1.0	0.0
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.4	-0.7	-0.5
Heel T-Score	0.3	2.0	2.7	-1.1	-1.6
Hypothyroidism (self reported)	0.3	0.6	1.3	-0.2	1.1
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.7	-0.9	-0.5
Hair Pigment	0.3	8.1	8.9	2.7	3.0
Tanning	0.3	4.2	8.3	-0.4	-2.9
Hand grip strength (left)	0.3	0.7	1.2	1.1	0.4
Medication: Metformin	0.3	0.4	0.8	0.9	0.2
Trunk fat percentage	0.3	1.1	2.0	1.4	0.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.3	-0.5	0.5
Body mass index (BMI)	0.3	1.2	2.1	-0.6	-1.4
Leg predicted mass (left)	0.3	1.8	3.2	0.7	1.8
Medication: Lansoprazole	0.3	0.4	0.6	-0.8	-0.4
Exposure to tobacco smoke at home	0.3	0.4	0.4	-0.6	0.6
Peak expiratory flow (PEF)	0.3	0.6	1.1	0.3	1.1
Blood clot in the leg (DVT)	0.3	0.3	0.7	-0.1	0.8
Pulse rate, automated reading	0.3	1.0	2.0	-0.0	-1.4
Alcohol intake frequency.	0.3	0.7	1.0	1.0	-0.6
Overall health rating	0.3	0.7	1.0	-1.0	-0.6
Chest pain or discomfort	0.3	0.4	0.6	-0.4	-0.8
Leg pain on walking	0.3	0.3	0.3	-0.6	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.6	0.8	-0.2
Whole body fat-free mass	0.3	1.5	2.7	0.6	1.6
Mood swings	0.3	0.6	0.6	0.8	0.7
Medication for cholesterol	0.3	0.5	0.5	0.7	-0.7
Medication: Bendroflumethiazide	0.3	0.5	1.0	0.2	-1.0
Medication: Paracetamol	0.3	0.5	0.8	-0.9	-0.4
Illnesses of father: High blood pressure	0.3	0.4	0.5	0.6	0.7
Basal metabolic rate	0.3	1.5	2.4	0.8	1.6
Commuting to job workplace: Cycle	0.3	0.3	0.6	0.1	0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.5	-0.7	-0.7
Ovarian Cancer	0.2	0.3	0.4	-0.6	-0.5
Age at First Birth	0.2	0.2	0.4	0.7	-0.0
Mean Putamen Volume	0.2	0.2	0.4	0.6	-0.2
Primary Biliary Cirrhosis	0.2	0.3	0.5	-0.3	0.7
Allergy or Eczema	0.2	0.6	1.1	-0.3	-1.1
Townsend deprivation index at recruitment	0.2	0.2	0.4	0.6	-0.2
Trunk fat mass	0.2	1.0	1.4	1.2	0.7
Heart attack	0.2	0.3	0.3	0.5	-0.5
Medication: Ramipril	0.2	0.2	0.3	-0.6	-0.4
Weight	0.2	0.8	1.2	0.7	1.1
Trunk fat-free mass	0.2	1.4	2.6	0.5	1.6
Alcohol intake versus 10 years previously	0.2	0.2	0.5	-0.7	-0.0
Happiness	0.2	0.3	0.3	-0.4	-0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.3	0.4	-0.7	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	0.5	-0.5
Mouth/teeth dental problems: Dentures	0.2	0.3	0.6	-0.8	0.1
Medication: Cholesterol lowering	0.2	0.4	0.5	0.5	0.7
Trunk predicted mass	0.2	1.2	2.3	0.4	1.5
Hair/balding pattern: Pattern 4	0.2	0.5	1.0	0.3	-1.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.5	-0.3	-0.7
Body fat percentage	0.2	0.6	1.1	1.1	-0.3
Qualifications: College or University degree	0.2	0.5	0.9	-0.4	-0.9
Medication: Omeprazole	0.2	0.2	0.2	0.5	-0.4
Heart disease (mother)	0.2	0.3	0.4	-0.4	-0.7
Hypertension (Self-reported)	0.2	0.5	0.6	-0.8	0.6
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	-0.6	-0.3
Whole body water mass	0.2	1.4	2.5	0.5	1.6
Medication: Atorvastatin	0.2	0.2	0.4	-0.6	-0.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	-0.2	-0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.3	0.6	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.4	-0.2	0.6
Heart disease (siblings)	0.2	0.2	0.3	0.6	-0.3
Pack years of smoking	0.2	0.3	0.5	-0.2	-0.7
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.2	0.5	-0.4
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	-0.5	0.2
Prostate Cancer	0.1	0.1	0.2	-0.4	0.4
Bipolar Disorder (2011)	0.1	0.1	0.1	-0.2	0.3
Body Mass Index (BMI) (2010)	0.1	0.2	0.3	0.0	0.6
LDL Cholesterol	0.1	0.1	0.2	-0.1	0.4
Neuroticism (2016)	0.1	0.1	0.2	-0.1	0.4
Blood Red Count	0.1	0.7	1.4	-1.2	-0.3
Lung FEV1/FVC ratio	0.1	0.4	0.8	-0.2	0.9
Hearing difficulty/problems: Yes	0.1	0.1	0.2	0.1	0.5
Severe depression (siblings)	0.1	0.1	0.2	0.1	-0.5
Hand grip strength (right)	0.1	0.1	0.2	0.4	0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.1	0.3	-0.4
Qualifications: CSEs or equivalent	0.1	0.1	0.2	-0.3	-0.4
High blood pressure	0.1	0.4	0.5	-0.5	0.7
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.3	0.6	-0.4
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.2	-0.5
Impedance of leg (left)	0.1	0.4	0.9	0.9	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	0.2	0.6
Hearing difficulty/problems with background noise	0.1	0.2	0.3	-0.6	0.3
Allergy	0.1	0.3	0.5	-0.0	0.7
Arm fat percentage (right)	0.1	0.5	0.6	0.8	-0.6
Time employed in main current job	0.1	0.1	0.2	-0.4	0.2
Prospective memory result	0.1	0.1	0.1	-0.3	0.4
Arm fat mass (right)	0.1	0.2	0.4	0.6	-0.2
Comparative body size at age 10	0.1	0.4	0.5	-0.7	-0.5
Whole body fat mass	0.1	0.3	0.6	0.8	0.2
Leg fat mass (right)	0.1	0.2	0.3	0.3	-0.6
Arm predicted mass (right)	0.1	0.5	0.9	0.0	1.0
Number of full sisters	0.1	0.1	0.2	0.4	0.2
Arm fat percentage (left)	0.1	0.6	0.7	0.7	-0.8
Average weekly red wine intake	0.1	0.2	0.2	0.4	-0.4
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.2	0.4	0.4
Friendships satisfaction	0.1	0.1	0.2	0.0	0.4
Qualifications: nursing, teaching	0.1	0.2	0.3	0.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	-0.5	-0.1
Osteoarthritis (self-reported)	0.1	0.1	0.2	-0.5	-0.1
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	-0.4	-0.1
Ever taken oral contraceptive pill	0.1	0.1	0.1	-0.4	-0.2
Hearing aid user	0.1	0.1	0.1	0.1	-0.4
High cholesterol (Self-reported)	0.1	0.1	0.1	0.4	-0.4
Medication: Lisinopril	0.1	0.1	0.1	0.4	-0.2
Alcohol drinker status: Never	0.1	0.1	0.3	0.1	-0.5
Arm fat-free mass (left)	0.1	0.4	0.8	0.3	0.9
Risk taking	0.1	0.2	0.3	0.5	-0.4
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.2	0.5	-0.5
Cholesterol lowering medication	0.1	0.1	0.2	0.1	0.4
Leg fat mass (left)	0.1	0.3	0.3	0.5	-0.5
Arm predicted mass (left)	0.1	0.3	0.6	-0.2	0.7
Respiratory disease	0.0	0.1	0.1	0.3	-0.3
Average weekly spirits intake	0.0	0.0	0.1	-0.2	0.2
Diabetes (father)	0.0	0.0	0.0	-0.2	0.0
Impedance of leg (right)	0.0	0.2	0.4	0.6	-0.1
Taking other prescription medications	0.0	0.0	0.0	0.1	-0.1
Serious illness, injury or assault to yourself	0.0	0.0	0.0	0.2	-0.1
Chronic bronchitis/emphysema (father)	0.0	0.0	0.0	-0.2	-0.2
Waist circumference	0.0	0.2	0.3	-0.6	0.1
Alcohol usually taken with meals	0.0	0.1	0.1	-0.4	-0.0
Noisy workplace	0.0	0.0	0.1	-0.2	-0.2
Arm fat-free mass (right)	0.0	0.1	0.3	-0.0	0.5
Had major operations	0.0	0.1	0.1	-0.3	-0.1
Ever had bowel cancer screening	0.0	0.0	0.1	-0.1	0.3
Arm fat mass (left)	0.0	0.1	0.2	0.4	-0.3

Hub : Genes

EGR2

Models

Trait associations