Best TWAS P=8.03e-18 · Best GWAS P=7.8e-38 conditioned to 1.18e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PTEN | 0.07 | 0.00 | blup | 450 | 0.01 | 6.0e-02 | -8.7 | 8.6 | 8.0e-18 | 0.64 | 0.00 | 0.98 | TRUE |
| 2 | GTEx | Breast Mammary Tissue (Male) | FAS | 0.18 | 0.03 | enet | 5 | 0.05 | 3.0e-02 | 7.8 | 6.5 | 6.9e-11 | 0.10 | 0.04 | 0.56 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | FAS | 0.25 | 0.19 | lasso | 6 | 0.15 | 3.3e-05 | -5.1 | 5.2 | 2.7e-07 | 0.05 | 0.33 | 0.07 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | ATAD1 | 0.06 | 0.00 | lasso | 5 | 0.00 | 3.1e-01 | 2.3 | -5.2 | 1.7e-07 | -0.41 | 0.07 | 0.36 | TRUE |
| 5 | GTEx | Whole Blood | FAS | 0.08 | 0.01 | enet | 13 | 0.04 | 2.4e-04 | 4.6 | 7.2 | 6.1e-13 | 0.09 | 0.08 | 0.72 | TRUE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ATAD1 | 0.06 | 0.03 | enet | 11 | 0.02 | 2.8e-03 | -8.4 | 6.7 | 2.7e-11 | 0.29 | 0.05 | 0.26 | FALSE |