Hub : Genes

FAS

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.5690 0.0360 0.0e+00 0.539 0.488 0.589 0.306 0.449 6.0e-78 1.3e-67 4.8e-89 7.2e-38 2.1e-60
2 GTEx Adipose Subcutaneous 0.3440 0.0480 1.3e-14 0.158 NA 0.253 NA 0.246 6.9e-13 NA 1.1e-20 NA 4.1e-20
3 GTEx Adrenal Gland 0.5278 0.0744 2.8e-08 0.497 NA 0.472 NA 0.490 2.8e-20 NA 5.3e-19 NA 6.4e-20
4 GTEx Brain Caudate basal ganglia 0.7240 0.0730 4.5e-07 0.469 NA 0.404 NA 0.394 3.3e-15 NA 9.9e-13 NA 2.1e-12
5 GTEx Brain Cortex 0.4530 0.1110 2.4e-03 0.252 NA 0.128 NA 0.253 1.3e-07 NA 2.2e-04 NA 1.3e-07
6 GTEx Brain Hippocampus 0.7174 0.0907 4.3e-06 0.294 NA 0.336 NA 0.248 1.2e-07 NA 1.0e-08 NA 1.6e-06
7 GTEx Brain Nucleus accumbens basal ganglia 0.3750 0.1010 2.3e-03 0.200 NA 0.244 NA 0.128 4.7e-06 NA 3.4e-07 NA 2.7e-04
8 GTEx Brain Putamen basal ganglia 0.4240 0.0960 1.8e-04 0.351 NA 0.279 NA 0.270 3.3e-09 NA 2.4e-07 NA 4.0e-07
9 GTEx Breast Mammary Tissue 0.2870 0.0680 7.6e-06 0.127 NA 0.120 NA 0.027 4.9e-07 NA 9.6e-07 NA 1.6e-02
10 GTEx Breast Mammary Tissue (Male) 0.1773 0.1106 9.6e-02 0.028 NA 0.047 NA 0.029 7.5e-02 NA 3.0e-02 NA 7.2e-02
11 GTEx Breast Mammary Tissue (Female) 0.2517 0.0843 3.7e-03 0.193 NA 0.087 NA 0.149 2.0e-06 NA 1.4e-03 NA 3.3e-05
12 GTEx Esophagus Muscularis 0.1990 0.0580 1.1e-03 0.061 NA 0.051 NA 0.038 1.3e-04 NA 5.0e-04 NA 2.2e-03
13 GTEx Muscle Skeletal 0.1976 0.0480 1.2e-05 0.072 NA 0.072 NA 0.073 1.3e-07 NA 1.3e-07 NA 1.1e-07
14 GTEx Nerve Tibial 0.2398 0.0539 7.6e-07 0.140 NA 0.174 NA 0.176 3.8e-10 NA 2.4e-12 NA 1.7e-12
15 GTEx Skin Sun Exposed Lower leg 0.1200 0.0440 3.4e-03 0.014 NA 0.012 NA 0.024 2.3e-02 NA 3.3e-02 NA 3.8e-03
16 GTEx Whole Blood 0.0770 0.0290 3.6e-03 0.013 NA 0.037 NA 0.029 2.0e-02 NA 2.4e-04 NA 1.0e-03
17 METSIM Adipose 0.2839 0.0375 0.0e+00 0.212 0.201 0.280 0.262 0.274 4.0e-31 2.1e-29 3.9e-42 4.7e-39 3.7e-41
18 NTR Blood 0.0366 0.0119 1.4e-04 0.031 0.013 0.029 0.022 0.027 2.8e-10 2.7e-05 7.9e-10 9.6e-08 2.6e-09
19 ROSMAP Brain Pre-frontal Cortex 0.4737 0.0391 0.0e+00 0.425 0.414 0.482 0.462 0.473 1.6e-59 1.3e-57 2.5e-70 2.1e-66 1.7e-68
20 YFS Blood 0.1402 0.0255 0.0e+00 0.075 0.088 0.099 0.103 0.101 2.4e-23 2.6e-27 1.1e-30 5.5e-32 2.4e-31
21 TCGA Brain Lower Grade Glioma 0.0298 0.0145 5.9e-03 0.033 0.017 0.025 NA 0.015 1.1e-04 3.9e-03 6.1e-04 NA 7.1e-03
22 TCGA Lung Adenocarcinoma 0.0346 0.0170 7.8e-03 -0.002 0.009 0.002 NA -0.002 6.2e-01 3.0e-02 1.7e-01 NA 6.5e-01
23 TCGA Prostate Adenocarcinoma 0.0454 0.0214 3.4e-03 0.015 0.023 0.022 NA 0.016 9.6e-03 1.6e-03 2.1e-03 NA 7.7e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Bipolar Disorder (2018) 0.2 0.3 1.2 0.6 -0.2 0.0 0.3 0.6 1.1 0.3 0.5 -0.6 -0.8 -0.1 -0.9 -0.5 -0.5 -1.0 -0.3 -0.6 -0.4 0.7 -0.0 0.7 -0.8 0.0
Bipolar Disorder or Schizophrenia 0.6 1.4 3.5 1.6 -0.8 -0.2 1.3 1.4 0.8 1.9 0.9 -0.7 -0.6 -1.7 -0.8 -1.2 -1.3 -1.1 -1.1 -1.1 -1.4 1.6 0.1 1.2 -1.6 0.7
Depressed Affect (Nagel 2018) 0.3 0.7 2.0 -0.7 0.2 -1.4 -0.3 -0.6 -1.3 1.2 -0.1 0.5 0.3 0.9 0.5 0.5 0.5 0.7 -0.5 1.1 -0.0 -1.1 0.7 -1.3 -1.1 -1.1
Depression (Nagel 2018) 0.1 0.1 0.9 -0.2 -0.3 -0.3 0.0 0.1 -0.7 0.2 0.2 0.3 0.0 0.6 0.2 -0.3 -0.1 -0.4 -0.2 0.3 -0.1 -0.5 0.2 -0.5 -0.9 -0.6
Intelligence (Savage-Jansen 2018) 0.4 1.2 5.1 -1.0 1.1 -0.9 -1.0 -0.8 -1.8 -1.0 -1.2 0.9 0.6 0.9 0.9 0.8 0.9 0.3 -0.0 0.7 2.3 -1.2 1.4 -0.6 0.8 -1.3
Neuroticism (Nagel 2018) 0.1 0.3 1.3 -0.5 0.0 -0.3 -0.1 -0.4 -0.6 0.2 -0.2 0.2 -0.7 0.3 0.6 0.1 0.2 0.4 -1.1 0.6 -0.5 -0.8 0.3 -0.7 -0.9 -0.8
Schizophrenia (2018) 0.6 1.3 4.7 1.5 -0.9 -0.3 1.5 1.3 0.1 2.2 0.8 -0.4 -0.2 -2.1 -0.3 -1.2 -1.3 -0.6 -1.2 -1.0 -1.3 1.5 0.1 1.0 -1.3 0.9
Schizophrenia vs Biploar Disorder 0.1 0.1 0.7 0.3 -0.2 -0.3 0.4 0.1 -0.4 -0.1 -0.5 0.1 0.1 -0.8 -0.1 0.0 -0.3 0.6 -0.1 -0.2 -0.3 0.3 -0.4 0.3 0.3 0.9
Worry (Nagel 2018) 0.1 0.1 0.7 0.1 -0.2 -0.6 0.3 0.4 -0.3 -0.3 0.1 -0.4 -0.9 -0.5 -0.3 -0.1 -0.1 0.5 -0.5 0.2 -0.6 -0.0 0.0 -0.3 -0.3 -0.5
Alzheimer’s Disease (in mother) 1.2 1.5 2.9 1.5 -1.5 0.8 1.6 1.3 0.5 1.6 1.4 -0.1 -1.4 -0.9 -0.5 -1.7 -1.5 -1.0 -1.7 -1.3 -1.3 1.4 -0.9 1.0 -0.4 -0.3
Alzheimer’s Disease (in father) 0.4 0.5 3.8 -0.1 1.0 0.4 -0.2 -0.3 0.2 -0.2 -0.2 0.3 2.0 0.3 -1.6 0.5 0.3 -0.1 0.5 0.1 0.0 -0.1 -0.5 -0.1 1.0 0.7
Alzheimer’s Disease (including proxy) 0.8 1.1 2.4 1.4 -0.7 0.6 1.4 1.0 1.2 1.4 1.3 -0.0 0.1 -0.5 -1.5 -1.2 -1.1 -1.0 -1.0 -1.2 -1.0 1.4 -1.2 1.1 -0.0 0.0
Crohns Disease (2017) 1.0 2.2 13.0 1.4 -1.7 0.2 1.3 1.2 0.7 -0.1 1.4 -0.9 -3.6 -1.4 -0.8 -1.3 -1.0 -0.9 -3.3 -0.7 -1.2 1.1 -0.6 0.5 -2.1 -0.3
Irritable Bowel Disease (IBD) 0.6 1.3 9.0 0.2 -0.8 -1.7 0.1 0.2 -0.2 -0.3 0.4 -0.8 -3.0 -0.3 0.4 -0.2 0.1 0.4 -2.7 0.7 -0.4 0.3 0.6 -0.9 -2.2 -1.5
Ulcerative Colitis (UC) 0.7 1.4 9.1 -0.9 0.4 -3.0 -0.8 -0.7 -0.8 -0.0 -0.4 -0.1 -0.6 0.8 0.9 0.7 0.8 1.6 -0.8 1.7 0.5 -0.6 1.2 -2.0 -1.4 -1.8
Major Depression (MDD) 0.3 0.4 1.9 0.5 -0.4 -0.2 0.6 0.6 0.6 0.1 0.9 -0.3 0.1 -0.4 -0.5 -0.7 -0.9 -0.6 -0.5 -0.3 -1.4 0.4 -0.9 0.3 -0.5 0.3
Reaction Time 1.3 2.5 7.4 -1.3 2.0 -1.1 -1.3 -1.5 -0.3 -2.7 -2.0 1.9 1.4 1.5 0.2 1.8 1.6 2.0 1.6 1.5 0.9 -1.2 0.7 -1.2 2.6 -0.8
Verbal and Numeric Reasoning (VNR) 0.7 1.6 5.0 -1.4 1.2 -1.3 -1.3 -1.3 -1.7 -1.2 -0.9 0.5 0.6 1.4 1.0 1.4 1.4 1.0 0.3 1.4 2.2 -1.6 0.7 -1.3 0.7 -1.6
Breast Cancer 0.3 0.8 3.3 0.6 -1.1 1.2 0.7 0.4 1.8 0.5 1.0 -0.0 0.1 -0.6 -0.6 -1.0 -1.0 -1.3 -0.2 -1.2 -0.8 0.8 -1.0 0.9 0.2 1.0
Ovarian Cancer 0.5 0.7 3.5 0.7 -1.0 0.4 0.9 0.3 0.5 0.3 1.2 -1.9 -0.7 -0.9 -0.4 -0.4 -0.9 -0.3 -0.7 -1.0 -0.2 0.4 -1.1 1.1 -0.2 0.9
Prostate Cancer 3.5 5.0 9.3 2.4 -2.6 0.3 2.5 2.6 1.2 3.0 2.7 -1.2 -2.3 -2.1 -1.0 -2.8 -2.6 -2.4 -2.6 -2.2 -2.0 2.5 -1.9 2.0 -2.8 0.9
Age at First Birth 0.5 0.7 2.9 -0.6 0.1 -1.6 -0.9 -0.3 -1.2 0.1 -0.4 -0.1 -0.5 0.3 0.9 0.9 1.0 1.0 -0.1 0.9 1.2 -0.3 1.7 -0.9 -0.3 -1.1
Bipolar Disorder (2011) 2.2 2.2 7.0 1.5 -1.5 1.1 1.7 1.3 2.6 0.6 1.5 -1.3 -0.6 -1.4 -2.3 -1.7 -1.7 -1.3 -0.5 -1.6 -2.0 1.5 -0.7 1.6 -0.7 0.3
Body Mass Index (BMI) (2010) 0.2 0.3 1.7 0.6 -0.6 -0.3 0.6 0.3 0.2 -0.3 0.3 -0.6 -1.3 0.0 0.2 -0.3 -0.3 0.3 -1.2 -0.5 -0.3 0.6 0.3 0.7 -0.4 -0.1
Coronary Artery Disease (CAD) 1.7 2.0 4.0 -1.8 1.9 0.3 -1.7 -1.3 -1.0 -1.7 -2.0 1.8 0.0 1.3 1.1 1.3 1.5 0.9 -0.0 1.5 1.8 -1.7 1.6 -1.6 1.1 -0.9
Crohns Disease (2012) 1.2 2.0 16.9 1.0 -1.7 -0.6 0.8 1.1 -0.0 -0.6 0.6 -0.7 -4.1 -0.6 -0.1 -1.1 -0.5 -0.7 -3.2 -0.5 -0.5 1.1 0.5 0.5 -2.2 -1.0
Mean Putamen Volume 0.9 1.0 2.7 1.1 -1.2 0.0 0.8 1.3 1.0 1.0 1.0 -0.6 -1.6 -0.8 -1.2 -1.1 -0.7 -0.9 -1.6 -1.0 -1.1 1.4 0.3 1.0 -0.4 0.2
Fasting Glucose 0.6 0.8 3.4 1.2 -0.6 -0.7 1.1 1.0 1.8 0.2 0.7 -0.2 -0.2 -0.9 -0.9 -0.8 -0.9 -0.6 -0.9 -0.8 -1.1 1.2 -0.0 0.9 -0.7 0.5
HbA1C 0.9 1.0 2.5 -1.3 0.9 -0.7 -1.4 -1.3 -0.7 -0.4 -1.6 0.7 0.4 1.6 1.3 0.8 1.1 0.4 0.2 0.9 0.8 -1.2 0.7 -1.0 1.1 -1.4
HDL Cholesterol 0.1 0.2 1.0 0.4 0.2 -0.4 0.3 0.1 -0.3 0.5 -0.2 0.1 0.3 -0.9 0.2 0.0 -0.3 0.2 0.7 -0.1 -1.0 0.2 -0.2 0.1 -0.4 0.3
LDL Cholesterol 0.1 0.2 0.7 0.4 0.1 0.5 -0.1 0.7 0.1 -0.7 -0.5 -0.6 0.1 -0.1 -0.3 -0.2 0.0 -0.4 0.1 0.1 -0.8 0.6 0.1 0.0 0.3 0.3
Lupus 0.5 0.8 1.5 1.1 -0.9 0.8 1.0 1.0 1.2 0.0 0.3 -1.0 -1.2 -1.0 -0.7 -1.1 -1.1 -0.9 -0.0 -1.0 -0.0 0.9 -1.1 0.8 0.7 0.4
Neuroticism (2016) 0.3 0.4 1.4 -0.3 -0.1 -1.1 -0.1 -0.2 0.0 1.1 -0.1 0.5 -0.8 0.3 1.2 0.2 0.2 0.2 -1.2 0.6 0.5 -0.3 -0.0 -0.8 -0.4 -0.8
Primary Biliary Cirrhosis 0.6 0.9 2.0 1.4 -0.8 0.1 1.2 0.9 0.4 1.1 0.9 -0.8 -0.1 -1.4 -0.6 -0.7 -1.1 -1.3 -0.9 -1.0 -0.6 1.0 -0.7 1.1 -1.3 0.8
Rheumatoid Arthritis 0.7 0.9 3.2 0.8 0.2 1.2 0.9 0.8 0.7 0.1 0.2 0.5 1.7 -1.6 -1.0 -0.4 -0.9 -1.2 0.6 -0.7 -0.7 0.1 -1.5 0.7 0.3 1.8
Schizophrenia (2014) 0.1 0.3 1.2 0.4 0.2 -1.1 0.2 0.3 -1.0 0.9 -0.4 -0.2 -0.1 -1.0 -0.1 0.1 -0.1 0.6 -0.2 0.1 -0.3 0.4 1.0 0.1 -0.7 0.2
Triglycerides 1.0 1.7 4.2 1.3 -1.1 1.6 1.1 1.4 1.2 0.9 1.6 -1.4 -0.7 -1.3 -1.7 -1.2 -1.1 -1.2 -0.6 -1.7 -0.3 1.3 -0.4 1.8 -0.8 2.0
Type 2 Diabetes (T2D) (2012) 0.4 0.4 2.2 0.4 0.0 1.5 0.3 0.7 0.5 -0.4 0.3 0.4 0.3 -0.4 0.5 -0.6 -0.4 -0.7 0.2 -0.8 -1.4 0.6 0.2 0.9 0.6 0.6
Ulcerative Colitis 1.0 1.5 11.3 -0.4 0.4 -3.4 -0.6 -0.1 -0.8 -0.2 -0.9 -0.1 -1.0 0.4 1.0 0.6 0.8 1.4 -0.8 1.5 1.4 -0.0 1.5 -1.5 -0.6 -2.3
Blood Eosinophil Count 2.5 19.1 51.8 -4.8 5.1 0.4 -4.9 -4.4 -4.4 -3.2 -3.2 4.2 6.5 5.2 4.8 4.0 4.4 3.0 7.2 3.1 4.8 -4.7 3.9 -2.8 4.7 -1.7
Blood Platelet Count 0.7 7.9 16.5 -2.9 2.5 -2.2 -2.8 -2.7 -2.2 -3.5 -2.3 2.9 2.2 3.4 3.4 2.2 2.6 2.2 2.1 2.7 3.3 -2.8 3.7 -2.8 1.9 -4.1
Blood Red Count 3.5 34.2 46.2 6.8 -6.5 3.5 6.8 5.7 6.6 6.8 5.1 -4.6 -4.7 -6.5 -5.4 -6.2 -6.8 -5.2 -4.1 -5.9 -6.2 6.2 -6.6 5.7 -5.5 5.5
Blood White Count 1.6 11.7 18.6 -3.5 3.4 -3.2 -3.9 -3.3 -3.2 -4.1 -3.2 1.7 0.8 3.6 3.9 3.9 4.1 4.0 1.9 3.8 4.3 -3.1 4.1 -3.5 2.5 -3.3
Heel T-Score 0.1 0.7 2.6 0.9 -0.6 0.2 1.2 0.4 -0.0 0.5 0.2 0.8 -0.4 -0.3 -1.0 -1.0 -1.3 -1.2 -0.8 -0.6 -1.1 0.4 -1.3 0.5 -1.6 0.2
BMI 0.1 0.5 2.5 0.1 -0.4 -0.7 0.4 0.1 0.1 1.6 0.5 -1.2 -0.2 -0.7 -1.3 0.2 -0.3 0.0 -1.6 0.1 -0.2 0.2 -0.3 0.1 -1.3 0.9
Height 0.1 1.2 3.6 1.4 -0.8 0.2 1.3 1.9 1.5 0.5 1.4 -0.8 -0.7 -1.9 -0.8 -0.9 -0.9 -1.2 -0.1 -1.4 -0.3 1.4 0.2 1.7 0.3 0.8
Waist Hip Ratio (WHR) 0.2 0.7 7.4 0.0 0.8 -0.2 -0.2 0.2 0.5 0.3 -0.6 1.5 1.6 0.3 0.4 0.2 0.3 0.4 2.7 0.1 0.2 0.3 -0.2 -0.1 1.1 0.3
Systolic Blood Pressure 0.2 0.9 5.6 -0.2 0.2 -2.4 -0.2 -0.1 -0.8 -1.0 -0.8 1.1 0.8 0.8 -0.1 0.3 0.5 0.9 0.8 1.0 -0.3 0.2 1.5 -1.0 0.6 -1.7
Smoking Status 0.7 1.6 5.6 -0.8 1.0 -2.2 -1.1 0.1 -0.2 -0.9 -0.1 1.5 2.2 0.3 2.4 0.7 1.1 1.1 1.6 0.9 0.1 -0.2 2.2 -0.6 1.8 -1.1
Allergy or Eczema 0.2 0.6 2.7 0.4 -1.0 1.0 0.5 0.9 -0.6 0.9 0.8 1.0 0.3 -0.3 0.1 -1.2 -0.8 -0.9 0.4 -0.5 -0.5 0.3 0.3 0.6 -1.6 -0.5
Cardiovascular Disease 0.2 0.7 2.1 -0.7 0.2 -1.4 -0.5 -0.6 -0.8 -0.8 -1.1 0.6 1.0 0.3 0.1 0.6 0.6 1.1 1.4 0.9 0.2 -0.5 0.9 -0.8 1.0 -0.6
Hypothyroidism (self reported) 6.0 13.7 23.1 4.5 -3.8 2.5 4.3 4.7 2.3 2.8 4.2 -3.0 -1.5 -4.4 -3.0 -4.4 -4.4 -3.9 -1.5 -4.7 -3.3 4.6 -2.2 4.8 -3.0 3.8
Respiratory disease 0.2 0.5 1.7 0.2 -0.4 0.5 0.4 0.7 0.1 0.8 0.7 -0.4 1.0 -0.6 -1.0 -0.6 -0.3 -1.1 1.3 -0.6 0.2 0.3 0.9 0.9 0.6 0.1
Type 2 Diabetes (T2D) (2018) 0.2 0.4 2.0 0.3 -0.4 0.3 0.1 0.7 0.1 1.4 -0.1 -0.4 -0.6 -0.4 -1.0 -0.4 -0.2 -0.8 -0.6 -0.6 -0.1 0.5 0.4 0.9 -1.0 0.6
Lung FEV1/FVC ratio 0.3 1.4 4.0 -0.8 1.6 -1.3 -1.3 -1.3 -0.2 -0.3 -1.3 0.8 2.0 0.8 0.9 1.9 1.4 1.9 1.1 1.3 1.2 -1.0 0.5 -0.9 0.8 0.0
Lung FVC 0.1 0.7 3.7 0.5 -1.0 1.3 0.4 0.5 -0.1 0.3 1.2 -1.9 -0.6 -0.7 -0.9 -0.5 -0.7 -1.4 -0.3 -0.5 -0.4 0.3 -1.0 0.4 -1.5 0.3
Neuroticism 0.5 1.1 3.4 -1.4 0.4 -1.0 -1.0 -1.0 -1.3 0.0 -0.9 -0.1 -0.2 0.7 0.8 1.1 1.1 1.5 0.5 1.7 0.3 -1.5 0.7 -1.9 -1.1 -1.1
Chronotype (morning person) 0.2 0.4 2.5 -0.5 0.5 1.6 -0.3 -0.6 -0.2 -0.6 -0.7 -0.1 0.6 0.3 -0.3 0.1 0.1 0.2 -0.1 -0.1 1.1 -0.6 -1.2 -0.0 0.8 0.6
Hair Pigment 0.0 1.0 4.3 0.7 -0.9 2.1 0.5 0.5 1.0 0.6 0.3 -1.1 -0.0 -1.4 -0.9 -0.5 -0.7 -1.0 0.5 -1.0 -1.3 0.5 -1.1 1.1 -0.2 1.9
Tanning 0.0 0.3 1.9 -0.1 0.1 -0.3 0.2 0.4 0.0 0.9 0.8 0.6 1.4 0.4 -0.6 -0.4 -0.4 -0.5 1.0 0.2 0.4 0.0 -0.1 -0.4 -0.5 -0.6
Hand grip strength (left) 0.3 0.7 3.4 -0.6 0.6 -1.8 -0.7 -0.8 -0.6 -0.9 -0.5 -0.3 0.2 0.6 -0.1 1.1 0.9 1.3 0.4 1.0 1.0 -0.6 1.4 -0.8 -0.5 -0.8
Number of treatments/medications taken 0.3 0.5 1.3 0.6 -0.8 -0.6 0.4 1.1 -0.1 1.1 0.6 -1.2 -0.7 -1.0 -0.3 -0.6 -0.4 -0.2 0.2 -0.2 -1.1 1.0 0.2 0.4 -0.9 0.2
Average weekly spirits intake 1.4 1.8 4.1 -1.2 1.3 -2.0 -0.9 -0.7 -0.3 -1.7 -1.2 1.1 1.4 0.7 1.8 1.0 1.1 1.5 0.9 1.5 1.1 -0.9 1.4 -1.6 2.0 -1.8
Sensitivity / hurt feelings 0.5 0.8 2.9 -1.1 -0.2 -0.3 -1.0 -0.7 -0.5 -1.4 -0.8 0.7 -1.2 1.1 1.7 0.3 0.7 0.3 -1.0 0.8 -0.2 -1.1 0.7 -0.8 0.3 -1.3
Frequency of depressed mood in last 2 weeks 0.3 0.4 2.0 -0.5 0.0 -0.6 -0.4 -0.0 -0.8 0.0 0.2 0.9 -0.7 1.0 1.4 -0.0 0.4 0.1 -0.9 0.5 0.4 -0.4 1.0 -0.5 -0.8 -0.8
Hearing difficulty/problems: Yes 0.3 0.4 1.4 -0.8 0.7 0.1 -0.7 -0.4 -0.3 0.5 -0.3 1.1 0.6 0.3 0.9 0.5 0.6 0.5 1.1 0.6 0.7 -0.7 0.4 -0.6 1.2 -0.1
Relative age of first facial hair 0.3 0.6 3.6 -0.3 -0.1 1.8 -0.8 -0.1 -0.9 -0.7 0.1 -1.5 -0.1 0.1 -0.4 0.1 0.3 -0.2 1.9 -0.4 0.4 -0.2 -0.1 0.5 0.3 1.0
Other serious medical condition/disability diagnosed by doctor 2.0 2.5 5.7 -1.7 1.3 -1.7 -1.8 -1.5 -2.3 -1.5 -1.5 0.3 0.7 1.8 1.5 1.7 1.7 2.4 1.6 1.5 1.5 -1.3 1.5 -1.3 1.8 -1.2
Ever used hormone-replacement therapy (HRT) 1.4 1.8 8.0 1.5 -1.7 -0.8 1.7 1.4 1.2 1.1 1.4 -1.1 -0.1 -1.8 -1.5 -1.2 -1.5 -0.0 -1.4 -0.5 -1.4 1.4 -0.8 0.4 -2.8 0.5
Ever had hysterectomy (womb removed) 2.2 2.5 6.5 1.9 -1.3 0.4 1.9 1.8 1.3 2.5 1.8 -0.6 -0.2 -2.0 -0.4 -1.7 -1.8 -0.6 -2.5 -1.4 -1.6 2.0 -1.2 1.3 -2.0 1.2
Systolic blood pressure, automated reading 0.1 0.2 1.2 -0.1 -0.5 -0.3 0.3 0.1 0.0 -0.1 -0.3 1.0 -0.1 0.2 -0.8 -0.4 -0.2 0.3 0.7 0.4 -0.8 0.1 0.1 -0.5 0.2 -1.1
Eye problems/disorders: Diabetes related eye disease 0.3 0.4 1.5 -0.6 0.4 0.8 -0.7 -0.1 -1.2 -0.5 -0.6 0.3 0.9 0.2 0.7 0.2 0.5 -0.5 0.5 -0.0 0.5 -0.5 0.9 0.0 1.2 0.4
Angina 0.3 0.3 0.9 0.7 -0.4 0.3 0.9 0.8 0.8 0.8 0.3 0.2 -0.0 -0.6 -0.1 -0.7 -0.7 -0.0 -0.5 -0.6 -0.4 0.6 -0.5 0.6 0.8 0.3
Medication for hormone replacement therapy 0.1 0.1 0.4 0.3 -0.2 -0.0 0.4 0.2 0.5 -0.5 0.0 0.3 -0.0 0.3 -0.5 -0.0 -0.1 0.6 -0.4 0.1 0.1 0.3 -0.5 -0.2 0.1 -0.2
Vitamin and mineral supplements 0.2 0.3 1.5 0.3 0.0 -1.1 0.1 0.7 -0.7 0.7 0.6 -0.3 -0.3 -0.1 0.0 -0.2 0.0 -0.1 -0.2 -0.5 0.2 0.7 1.2 0.8 -1.0 -0.1
Supplements: Zinc 0.5 0.5 3.0 -0.7 0.6 0.4 -0.7 -0.8 0.3 -0.8 -1.0 1.0 0.7 0.5 0.6 0.8 0.6 0.4 1.7 0.7 0.0 -0.7 -0.4 -0.8 0.6 0.6
Medication: Co-codamol 0.3 0.4 2.0 -0.5 0.4 1.2 -0.2 -0.8 0.7 -0.6 0.0 0.3 -0.0 1.1 -0.2 0.2 0.1 0.5 -0.1 0.1 -0.2 -0.6 -1.4 -0.2 1.1 0.0
Medication: Metformin 0.4 0.5 1.4 0.7 -0.5 0.9 0.7 0.8 0.7 1.1 0.0 0.4 0.2 -0.4 -0.7 -0.8 -0.6 -0.9 -0.4 -1.0 -1.1 0.6 -0.2 1.2 0.3 0.5
Diabetes (father) 0.2 0.3 1.9 0.1 -0.5 -0.2 0.4 -0.3 -0.2 0.4 -0.6 -0.8 -0.2 -0.6 -1.4 0.1 -0.3 -0.1 -0.6 0.2 -0.4 -0.2 -1.0 -0.3 -0.1 0.3
Diabetes (mother) 1.0 1.3 3.7 -1.2 0.8 -0.8 -1.2 -1.0 -1.5 -0.8 -0.4 0.8 0.1 1.3 1.9 0.8 1.2 1.2 0.3 1.2 1.4 -1.2 1.4 -1.3 0.3 -1.9
Severe depression (siblings) 0.5 0.5 1.9 0.5 -0.7 0.8 0.2 0.9 0.3 0.6 0.5 0.2 0.1 -1.1 -1.4 -0.6 -0.3 -0.4 0.8 -0.6 -0.8 0.7 0.5 0.8 -0.7 1.4
Pack years adult smoking proportion 4.3 6.5 10.4 -2.4 2.8 -3.2 -2.3 -2.4 -1.5 -3.0 -3.0 2.6 1.8 2.3 2.3 2.9 2.8 3.2 1.3 3.1 2.3 -2.2 2.2 -3.0 2.6 -2.4
Impedance of leg (right) 0.1 0.6 1.6 1.0 -0.7 0.0 0.9 1.0 0.8 0.4 0.9 -0.4 0.4 -1.3 -0.1 -0.9 -1.1 -0.6 0.5 -0.7 -1.0 0.9 -0.8 0.7 -0.6 0.9
Leg fat-free mass (left) 0.2 1.3 3.9 -1.3 1.5 -1.2 -1.3 -1.1 -0.8 -0.3 -1.2 0.4 0.6 1.1 0.6 1.5 1.5 1.2 0.0 1.1 1.7 -1.1 2.0 -0.9 0.8 -0.9
Trunk fat percentage 0.1 0.4 1.6 -0.3 0.4 -1.3 0.1 -0.5 -0.1 1.2 -0.4 0.6 0.4 -0.1 0.1 0.5 0.1 0.7 -1.2 0.7 0.2 -0.4 -0.5 -0.8 -0.8 0.2
Hand grip strength (right) 0.1 0.3 1.3 0.0 0.3 -0.3 -0.3 -0.2 -0.5 -0.9 -0.3 -0.6 0.4 0.2 -0.9 0.4 0.3 0.7 0.9 -0.1 0.3 0.1 1.2 0.4 0.2 0.1
Townsend deprivation index at recruitment 4.9 6.9 14.3 -2.6 2.5 -3.2 -2.5 -2.2 -2.0 -2.0 -2.2 3.8 2.0 2.8 3.0 2.4 2.7 2.5 1.9 2.9 3.2 -2.4 3.1 -2.9 1.6 -2.8
Current tobacco smoking 2.0 3.2 8.5 -1.4 1.8 -2.9 -1.6 -0.9 -0.5 -2.0 -1.1 1.4 2.5 1.3 1.9 1.8 1.9 2.0 2.4 1.8 1.1 -1.0 2.5 -1.4 2.2 -1.6
Average weekly fortified wine intake 0.4 0.4 1.8 0.2 -0.6 0.6 0.6 -0.1 0.9 -0.3 0.6 -1.3 -0.4 -0.4 0.3 -0.7 -0.9 -0.6 -0.7 -0.6 -0.9 -0.0 -1.3 0.4 0.1 0.1
Maternal smoking around birth 0.5 0.8 3.3 -0.8 1.3 -0.3 -0.9 -0.9 -1.1 -0.9 -0.3 0.6 1.8 0.1 0.6 1.3 1.0 0.7 0.6 0.5 0.7 -0.8 1.2 -0.2 0.8 0.9
Fed-up feelings 1.8 3.2 6.6 -2.3 1.5 -1.0 -1.9 -2.2 -2.2 -0.8 -1.5 1.4 1.3 2.1 1.5 1.9 1.9 2.2 1.0 2.2 1.8 -2.6 1.1 -2.4 0.2 -1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 3.0 -0.9 0.5 -0.5 -0.8 -0.7 -0.9 -0.2 -0.4 0.6 0.5 0.7 1.7 0.8 0.8 0.8 0.3 1.0 1.2 -1.1 0.7 -1.0 0.5 -0.5
Relative age voice broke 0.3 0.5 2.2 -0.6 -0.1 1.5 -0.6 -0.4 -1.0 0.5 0.4 -1.2 0.4 -0.2 1.1 0.1 0.1 -0.3 0.9 -0.4 0.6 -0.7 -0.1 0.5 0.4 1.2
Taking other prescription medications 0.1 0.2 0.8 0.5 -0.1 -0.5 0.1 0.9 -0.4 0.1 0.3 -0.6 -0.3 0.2 0.0 -0.1 0.1 0.4 0.3 -0.2 -0.1 0.8 -0.0 0.4 0.4 -0.3
Age when periods started (menarche) 0.0 0.1 0.7 -0.0 0.2 0.7 0.1 -0.1 -0.2 -0.8 0.1 0.1 0.4 -0.3 -0.3 0.1 -0.2 -0.1 -0.2 -0.1 0.0 -0.3 -0.6 0.1 0.3 0.6
Bilateral oophorectomy (both ovaries removed) 2.9 3.3 6.6 2.1 -1.3 0.5 2.0 2.2 1.7 2.3 1.3 -1.7 0.0 -2.1 -2.4 -1.9 -2.0 -1.2 -1.4 -1.9 -2.6 2.3 -1.1 2.0 -1.6 1.8
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 2.0 -0.4 0.4 -1.4 -0.4 -0.3 -0.1 -0.2 -0.5 -0.2 0.6 0.3 0.2 0.7 0.4 0.6 -0.2 0.7 -0.1 -0.3 0.1 -0.7 -0.5 0.4
Tinnitus: Yes, but not now, but have in the past 1.3 1.4 3.3 1.1 -1.3 0.8 1.1 1.3 0.8 1.1 1.3 -1.4 -0.1 -1.4 0.1 -1.4 -1.4 -1.7 -0.9 -1.3 -1.8 1.1 -1.6 1.1 -0.1 0.9
Qualifications: CSEs or equivalent 0.6 0.8 2.1 -1.1 0.7 -0.2 -0.8 -1.4 -0.1 0.2 -1.2 0.5 -0.5 0.9 -0.3 1.2 1.0 0.5 0.2 1.1 1.4 -1.4 -0.3 -1.5 0.6 -0.5
Serious illness, injury or assault to yourself 0.8 1.0 3.5 1.1 -0.5 0.7 0.6 1.3 -0.6 0.3 1.1 -1.9 0.2 -1.4 -0.9 -0.5 -0.6 -0.1 -0.1 -1.2 -1.0 1.3 -0.0 1.5 -1.0 1.4
High blood pressure 0.3 0.7 4.0 -0.5 0.4 -1.4 -0.5 -0.5 0.0 -0.8 -1.3 0.2 1.1 -0.1 -0.8 0.9 0.6 1.5 2.0 1.0 0.4 -0.4 0.2 -0.8 0.5 -0.4
Hayfever, allergic rhinitis or eczema 0.3 0.6 4.2 0.4 -1.1 1.1 0.5 0.7 -0.9 0.9 0.9 0.6 0.3 -0.4 0.5 -1.0 -0.7 -1.0 0.1 -0.5 -0.4 0.4 0.1 0.6 -2.1 0.2
Multivitamins +/- minerals 0.2 0.3 1.3 -0.0 0.4 0.5 -0.1 -0.6 1.1 -0.8 -0.8 -0.4 0.3 -0.1 -0.2 0.6 0.2 0.3 0.5 0.6 0.1 -0.5 -0.6 -0.7 0.3 0.2
Stomach or abdominal pain in last month 0.3 0.4 1.9 -0.8 0.4 0.1 -0.8 -0.7 -0.2 -0.2 -0.0 0.1 0.4 0.8 1.4 0.6 0.7 0.6 0.4 0.8 0.4 -0.6 0.1 -1.0 0.7 -0.4
Supplements: Glucosamine 0.9 1.2 3.6 1.2 -1.0 -0.2 1.3 0.8 0.8 1.9 1.1 -1.2 -1.0 -1.1 -1.4 -0.6 -1.1 -1.3 -1.3 -0.6 -0.5 0.5 -1.3 0.6 -1.8 0.5
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 2.2 0.6 -0.8 1.5 0.6 0.7 0.8 1.5 0.9 -0.8 -0.3 -0.1 -0.4 -1.1 -0.9 -1.5 -0.5 -0.9 -1.0 0.5 -1.5 0.7 -0.6 0.6
Medication: Atenolol 0.2 0.2 1.6 -0.3 0.1 -1.0 -0.2 -0.1 -1.3 0.1 -0.4 -0.5 0.0 -0.3 0.5 0.3 0.2 0.9 -0.3 0.4 0.3 -0.3 0.4 -0.4 0.4 -0.3
Medication: Levothyroxine sodium 2.3 3.9 7.4 2.2 -2.0 2.1 2.3 2.5 0.8 1.5 1.7 -1.1 -1.3 -2.2 -1.8 -2.7 -2.4 -2.4 -1.1 -2.7 -1.0 2.4 -1.3 2.6 -1.5 1.5
Sitting height 0.2 1.1 9.6 -0.8 1.0 -2.0 -0.9 -0.4 -1.0 -0.4 -0.0 0.5 0.4 0.5 0.6 0.9 1.1 1.0 0.1 0.7 1.1 -0.4 3.1 -0.5 0.1 -1.7
Chronic bronchitis/emphysema (father) 0.7 0.8 3.5 0.9 -0.5 1.1 1.2 0.7 0.5 1.9 0.7 -0.3 1.2 -1.4 0.1 -0.8 -1.1 -0.4 -0.6 -0.9 -0.8 0.7 -0.7 0.8 -0.8 1.2
High blood pressure (mother) 0.4 0.6 2.2 -0.6 1.0 -0.5 -0.5 -0.3 -1.3 -0.6 -0.4 1.2 0.9 0.5 0.8 0.3 0.6 0.7 0.2 0.7 0.6 -0.4 1.5 -0.8 0.2 -1.4
Body mass index (BMI) 0.1 0.5 1.4 -0.6 0.5 -0.9 -0.4 -0.7 -0.6 0.9 -0.5 0.5 0.4 0.5 0.3 0.9 0.6 0.9 -0.9 0.9 0.6 -0.6 0.1 -0.9 -1.2 -0.2
Impedance of leg (left) 0.1 0.5 1.1 1.0 -0.3 0.1 0.8 0.8 0.9 0.1 0.7 0.0 0.9 -1.0 -0.2 -0.6 -0.8 -0.2 0.8 -0.6 -1.1 0.8 -0.8 0.6 0.1 0.9
Leg predicted mass (left) 0.2 1.2 3.7 -1.3 1.5 -1.1 -1.3 -1.1 -0.8 -0.3 -1.2 0.3 0.6 1.0 0.6 1.5 1.5 1.2 0.0 1.0 1.7 -1.1 1.9 -0.8 0.8 -0.8
Trunk fat mass 0.1 0.6 2.6 -0.7 0.8 -1.6 -0.4 -0.8 -0.3 0.9 -0.7 0.8 0.6 0.3 0.4 1.0 0.7 1.0 -0.8 1.1 0.8 -0.8 0.4 -1.0 -0.6 -0.2
Waist circumference 0.1 0.2 1.2 -0.0 0.5 -0.7 -0.0 0.1 0.0 1.1 -0.3 0.7 0.8 -0.0 -0.0 0.5 0.4 0.6 -0.0 0.3 0.3 0.2 0.3 -0.1 -0.6 0.7
Number of incorrect matches in round 0.2 0.3 1.5 0.2 -0.6 0.7 0.6 0.2 0.4 -0.0 0.4 -0.0 -1.1 -0.6 0.6 -0.4 -0.5 -0.5 -1.2 -0.0 -0.1 -0.1 -0.6 -0.2 0.1 -0.2
Past tobacco smoking 0.5 0.9 2.4 -0.7 0.7 0.4 -0.8 -1.6 -0.8 -1.5 -1.5 -0.9 -0.5 0.8 -0.3 1.5 0.9 0.9 0.3 1.0 1.1 -1.2 -0.4 -0.9 0.0 0.5
Alcohol usually taken with meals 3.9 6.4 10.0 2.7 -2.6 2.5 2.5 2.2 1.9 2.7 2.1 -2.5 -1.3 -3.0 -2.6 -2.5 -2.7 -2.5 -2.5 -2.9 -3.2 2.4 -2.7 2.9 -1.4 2.8
Nervous feelings 0.5 1.0 6.0 -1.0 0.1 -0.7 -0.5 -0.7 -1.0 -1.3 -0.6 0.7 -2.5 0.8 0.2 0.1 0.6 0.4 -0.6 0.9 0.8 -1.0 0.9 -1.1 -0.6 -2.0
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 2.0 0.1 0.1 -0.8 -0.1 0.4 -0.1 0.8 0.4 0.5 -0.6 0.3 -0.0 -0.2 0.1 -0.1 -1.4 0.1 -0.3 0.2 0.5 -0.1 -1.2 -0.2
Hearing difficulty/problems with background noise 0.1 0.2 1.6 0.1 -0.4 0.1 0.4 0.1 0.0 0.3 0.4 0.1 -0.7 -0.7 0.2 -0.2 -0.3 0.3 -1.3 -0.0 -0.5 0.1 0.0 -0.0 -0.3 0.2
Hair/balding pattern: Pattern 2 2.0 2.5 4.5 -1.9 1.7 0.2 -1.4 -2.0 -1.4 -1.7 -2.0 2.1 1.7 1.3 0.5 1.7 1.5 1.9 1.4 1.6 1.8 -1.8 -0.0 -1.8 2.0 -0.2
Had menopause 0.3 0.4 2.0 0.3 -1.1 -0.3 0.8 0.0 -0.8 0.8 0.6 -0.1 -0.2 -0.3 0.5 -0.5 -0.6 0.8 -0.7 0.3 -0.4 -0.0 -0.8 -0.5 -0.4 -1.4
Had other major operations 0.4 0.4 2.6 0.4 -0.4 0.7 0.7 0.5 -0.1 1.6 0.5 -0.5 1.0 -0.8 -0.3 -0.6 -0.7 -0.5 0.3 -0.7 -0.6 0.2 -0.8 0.6 0.2 0.8
Forced vital capacity (FVC) 0.1 0.2 1.1 -0.1 0.3 0.0 -0.3 0.1 -0.2 0.4 0.2 -1.0 -0.0 -0.3 -0.7 0.3 0.1 -0.8 0.8 -0.1 0.1 -0.1 0.6 0.3 -1.1 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 1.5 0.2 0.4 -1.2 0.4 0.0 0.7 0.5 -0.0 0.3 1.0 -0.2 -0.3 0.2 -0.3 0.2 0.2 0.3 -0.5 0.2 -0.5 -0.3 -1.2 0.7
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 1.4 0.4 -0.4 0.0 0.5 0.3 1.2 0.6 0.4 -0.3 0.8 -0.7 -0.8 -0.3 -0.5 -0.4 0.7 -0.1 -0.4 0.3 -0.4 0.1 -0.1 0.5
Qualifications: None of the above 0.1 0.2 0.9 -0.2 -0.2 0.9 0.2 -0.0 0.0 0.3 0.8 0.1 0.6 0.0 0.5 -0.5 -0.5 -0.5 0.2 -0.2 -0.6 -0.5 -0.9 0.1 -0.2 0.4
Financial difficulties in last 2 years 0.5 0.7 2.6 0.8 -0.9 -0.6 0.5 1.4 1.0 0.2 1.1 -0.4 -1.6 -0.2 1.1 -0.9 -0.5 -0.2 -1.1 -0.9 -0.6 1.3 -0.3 1.0 0.8 0.1
Mouth/teeth dental problems 1.2 1.9 3.6 1.9 -1.3 0.6 1.7 1.9 0.6 0.9 1.3 -1.2 -0.9 -1.5 -1.2 -1.8 -1.7 -1.3 -1.0 -1.7 -1.1 1.9 -0.7 1.7 -1.3 0.8
Heart attack 0.3 0.3 2.5 -0.0 1.1 -0.2 -0.3 0.5 -0.4 -0.5 -0.1 0.4 1.1 0.3 -0.5 0.4 0.6 0.0 1.6 0.2 0.3 -0.0 0.4 0.0 0.6 0.0
Allergy 0.2 0.3 2.1 0.3 0.1 -0.6 -0.0 -0.2 0.8 0.1 -0.2 -1.4 -1.2 -0.5 -0.3 0.3 0.0 0.6 -0.8 0.1 -0.7 0.1 -0.8 -0.2 0.7 0.4
Pain all over the body in last month 0.2 0.2 1.4 -0.2 -0.2 -0.8 -0.1 -0.1 0.1 0.5 0.3 0.2 0.7 0.1 1.2 -0.1 -0.0 0.6 0.2 0.3 -0.1 -0.1 -0.5 -0.5 0.6 -1.0
Diabetes (self-reported) 0.1 0.1 0.6 -0.0 0.3 -0.2 -0.2 0.3 -0.3 0.1 -0.7 0.6 0.8 -0.0 -0.2 0.0 0.2 -0.1 0.5 -0.2 -0.1 0.1 0.6 0.4 0.3 0.3
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.5 0.6 -1.1 0.1 0.7 0.7 -0.1 1.2 0.5 -0.9 0.5 -1.1 0.0 -0.6 -0.8 -0.3 -0.2 -0.5 0.4 0.5 -0.3 0.4 -0.6 0.3
Medication: Ramipril 1.0 1.3 2.5 -1.1 1.4 -1.5 -0.9 -0.8 -0.4 -0.6 -1.4 1.3 1.5 1.0 0.8 0.9 1.0 1.2 1.2 1.3 0.5 -1.1 1.2 -1.2 1.0 -1.6
Medication: Simvastatin 0.2 0.3 2.7 -0.0 -0.1 -0.1 0.4 -0.0 -0.7 0.4 -0.3 1.6 -0.6 -0.0 0.3 -0.3 -0.2 0.4 -1.3 0.3 -0.5 -0.1 -0.7 -0.6 -0.1 -0.7
Fluid intelligence score 0.7 1.4 3.5 -1.3 1.1 -1.4 -1.2 -1.1 -1.1 -1.2 -1.4 1.0 -0.1 1.4 1.0 1.1 1.2 0.6 -0.2 1.4 1.7 -1.4 0.9 -1.5 0.2 -1.9
Illnesses of siblings 0.4 0.5 1.1 0.8 -0.9 0.8 0.8 0.5 0.1 0.9 0.8 -0.4 -0.4 -0.4 -0.4 -0.9 -1.0 -1.0 -0.0 -1.0 -0.7 0.7 -1.0 0.9 -0.4 0.6
Neuroticism score 0.3 0.5 2.0 -1.0 0.1 -0.3 -0.4 -0.9 -0.8 -0.2 -0.6 0.4 -1.1 0.6 0.7 0.4 0.4 0.7 -0.5 0.9 0.5 -1.4 0.1 -1.2 -0.2 -1.0
Weight 0.1 0.7 2.1 -0.8 0.9 -1.4 -0.6 -0.8 -0.3 0.8 -0.6 0.8 0.5 0.6 0.3 1.1 0.9 1.1 -0.6 1.0 1.1 -0.7 0.9 -0.9 -0.4 -0.6
Impedance of arm (right) 0.3 1.2 2.4 1.3 -1.3 0.3 1.3 1.1 1.2 0.5 0.6 -1.0 -1.4 -1.2 -0.6 -1.4 -1.5 -1.2 -1.1 -1.2 -1.2 1.2 -1.5 1.0 0.2 0.8
Arm fat percentage (right) 0.1 0.4 3.1 -0.0 -0.1 -0.7 0.4 -0.3 0.3 1.6 -0.1 0.1 -0.0 -0.1 -0.0 0.2 -0.2 0.0 -1.8 0.3 0.1 -0.2 -1.1 -0.4 -1.0 0.3
Trunk fat-free mass 0.3 1.6 6.2 -1.4 1.6 -1.1 -1.5 -1.1 -0.7 -0.4 -0.9 0.9 1.2 1.2 0.7 1.7 1.7 1.2 0.6 1.1 1.9 -1.2 2.5 -0.8 0.8 -1.1
Hip circumference 0.2 0.8 3.5 -0.7 0.8 -1.9 -0.8 -0.6 -0.6 0.5 -0.5 0.2 0.4 0.6 0.4 1.2 1.1 1.2 -0.9 1.0 0.8 -0.5 1.4 -0.8 -0.7 -0.3
Time employed in main current job 0.3 0.3 0.8 0.5 -0.2 -0.6 0.6 0.8 0.0 0.6 0.3 0.7 -0.7 -0.4 0.5 -0.9 -0.6 -0.5 -0.8 -0.4 -0.3 0.8 0.6 0.3 -0.8 -0.7
Alcohol intake versus 10 years previously 2.8 4.2 8.0 -2.1 2.2 -1.9 -2.0 -2.5 -1.5 -2.5 -2.4 1.5 1.2 2.6 0.9 2.6 2.3 2.8 2.1 2.4 2.0 -2.1 1.0 -2.3 1.1 -1.8
Father’s age at death 0.9 1.2 2.8 1.1 -1.3 1.7 1.1 1.1 -0.1 1.0 1.3 -1.0 -0.7 -0.8 -0.9 -1.6 -1.4 -1.3 -0.8 -1.4 -0.3 0.7 -0.9 1.3 -1.6 0.6
Worrier / anxious feelings 0.2 0.3 1.8 -0.6 -0.2 -0.4 -0.4 -0.2 -1.3 0.1 -0.5 -0.3 -1.1 -0.2 0.5 0.2 0.3 0.4 -0.0 0.6 -0.1 -0.7 0.6 -0.7 0.1 -1.0
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.5 -0.5 0.2 -0.4 -0.3 -0.2 0.1 0.6 0.5 0.2 0.7 0.3 0.5 0.3 0.3 -0.1 0.4 0.2 0.5 -0.5 0.4 -0.3 -0.5 0.1
Falls in the last year 1.5 2.1 3.5 1.5 -1.8 1.3 1.6 1.8 0.6 1.8 1.7 -1.1 -1.3 -1.6 -1.1 -1.9 -1.7 -1.5 -0.9 -1.6 -1.7 1.4 -0.8 1.4 -1.2 1.2
Hair/balding pattern: Pattern 3 0.3 0.4 2.6 0.2 -0.7 -1.0 -0.1 0.4 -0.6 1.2 0.3 -1.1 -1.6 -0.2 0.2 -0.2 0.0 -0.5 -0.4 -0.0 -0.3 0.2 0.8 0.2 -0.2 -1.2
Number of live births 1.3 1.8 4.8 1.1 -1.5 1.4 1.1 1.5 1.1 2.0 1.6 -1.3 -1.0 -1.3 -1.0 -1.7 -1.5 -2.2 -0.5 -1.4 -0.8 1.0 -1.3 1.2 -0.9 1.0
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 0.6 -0.5 0.6 -0.2 -0.6 -0.7 -0.3 0.0 -0.3 -0.5 0.4 0.1 0.0 0.8 0.5 -0.1 0.4 0.4 0.6 -0.6 0.5 -0.3 -0.6 0.1
Pulse rate 0.1 0.2 1.2 0.4 -0.8 0.3 0.5 0.2 0.3 0.6 0.4 -0.4 -0.5 -0.9 -1.1 -0.2 -0.3 0.0 -0.3 -0.2 -0.3 0.3 0.1 0.2 -0.4 0.3
Happiness 2.7 3.3 6.3 -2.3 1.8 -0.9 -2.2 -2.0 -2.0 -1.4 -1.6 1.6 1.2 2.4 1.6 1.8 1.9 1.6 2.5 1.8 1.5 -2.3 1.5 -1.8 1.7 -1.6
Noisy workplace 0.5 0.6 2.0 0.8 -0.4 -1.1 0.6 1.4 -0.3 0.8 0.9 -0.2 0.2 -0.8 1.1 -0.9 -0.5 -0.6 -0.5 -0.2 -1.2 1.3 0.8 0.1 -0.7 -0.3
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.4 0.7 -0.6 0.6 0.3 0.6 -0.6 0.4 0.8 -0.8 -1.2 -0.1 -0.0 -0.8 -0.5 -0.9 -0.9 -0.9 0.2 0.6 0.4 1.0 -1.2 -0.2
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.5 -0.7 0.9 -0.9 -0.5 -0.6 -0.1 -0.5 0.2 0.3 0.9 1.1 0.3 0.8 0.5 0.4 1.2 0.7 0.6 -0.6 -0.4 -0.7 -0.5 -0.6
Mouth/teeth dental problems: Dentures 0.3 0.4 1.6 -0.6 0.1 -0.8 -0.5 -0.4 0.7 -0.2 -0.1 1.1 0.1 0.4 0.2 0.6 0.7 1.0 0.8 1.0 0.4 -0.2 0.3 -1.0 0.6 -1.3
Asthma 0.2 0.4 2.0 -0.2 0.3 0.5 0.0 0.2 0.1 0.3 0.1 0.5 1.2 0.2 -1.0 -0.1 0.2 -0.7 1.4 -0.1 1.1 -0.1 1.0 0.2 0.5 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.8 -0.3 0.5 -0.1 -0.4 -0.2 -0.1 -0.9 -0.6 -0.1 0.1 0.4 -0.7 0.3 0.3 0.1 -0.1 0.0 -0.6 -0.1 0.2 0.0 0.1 0.4
Medication: Cholesterol lowering 0.6 0.9 2.4 1.3 -0.5 0.8 1.2 1.6 -0.7 0.5 0.6 -0.5 -0.3 -1.4 -0.5 -1.2 -0.9 -0.9 -1.3 -1.2 -1.0 1.3 0.2 1.3 -0.6 0.7
Depression (self-reported) 0.2 0.2 1.0 -0.1 0.0 -0.7 -0.1 0.5 0.8 0.2 0.5 0.9 -0.2 0.4 -0.5 -0.3 0.1 -0.1 0.2 0.3 0.3 0.2 -0.3 -0.4 -0.4 -1.0
Medication: Lansoprazole 0.3 0.4 2.5 -0.1 0.9 -0.4 -0.4 -0.3 -0.7 -0.2 -0.6 1.0 1.6 0.3 0.6 0.7 0.6 0.1 0.4 0.6 -0.2 -0.4 0.1 -0.4 0.7 0.1
Prospective memory result 0.2 0.2 1.4 0.5 0.0 0.3 0.4 0.6 1.2 0.4 0.6 1.0 0.5 -0.3 -0.4 -0.4 -0.3 -0.2 0.3 -0.4 0.1 0.5 -0.4 0.4 -0.3 0.2
Lung cancer (father) 0.2 0.3 1.2 0.4 -0.8 1.1 0.4 0.5 0.7 -0.0 0.7 -0.1 -0.3 -0.2 -0.5 -0.7 -0.5 -0.6 -0.9 -0.4 -0.2 0.3 -0.6 0.3 0.0 -0.2
Illnesses of mother 0.5 0.6 4.4 0.2 -0.4 0.7 -0.1 0.0 0.6 0.9 0.3 -1.5 0.3 -0.3 -1.3 0.3 -0.2 -0.8 0.1 -0.4 -0.0 0.2 -0.8 0.6 -0.9 2.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.4 -0.3 0.5 -0.1 -0.2 -0.6 -0.3 0.0 -0.2 -0.6 0.4 -0.2 0.6 0.5 0.1 -0.4 0.4 0.2 0.2 -0.6 -0.0 -0.1 -0.5 0.1
Pulse wave Arterial Stiffness index 0.2 0.2 1.0 0.1 0.7 -0.6 0.1 -0.4 1.0 0.3 -0.1 0.5 0.1 0.1 -0.7 0.3 0.1 0.6 -0.5 0.4 0.7 0.0 0.6 -0.4 -0.8 -0.4
Impedance of arm (left) 0.4 1.7 3.7 1.5 -1.4 0.4 1.7 1.3 1.1 0.8 0.9 -1.2 -1.6 -1.4 -1.0 -1.7 -1.8 -1.4 -1.4 -1.3 -1.5 1.3 -1.9 1.0 0.2 0.8
Arm fat mass (right) 0.1 0.4 1.5 -0.5 0.6 -1.1 -0.2 -0.7 0.0 1.2 -0.5 0.5 0.4 0.3 0.2 0.8 0.5 0.7 -1.1 0.8 0.6 -0.6 -0.2 -0.8 -0.6 -0.1
Trunk predicted mass 0.3 1.7 6.4 -1.4 1.7 -1.1 -1.5 -1.1 -0.7 -0.4 -0.9 0.8 1.2 1.2 0.6 1.7 1.7 1.2 0.7 1.1 1.9 -1.2 2.5 -0.8 0.8 -1.1
Standing height 0.1 0.6 4.0 -0.4 1.0 -1.4 -0.5 -0.1 0.7 -0.2 -0.2 0.5 0.0 0.2 0.0 0.6 0.6 0.6 0.3 0.2 1.2 -0.3 2.0 -0.0 1.4 -0.9
Length of working week for main job 0.5 0.6 1.9 -0.6 0.8 -1.0 -0.5 -0.8 -1.4 0.4 -0.4 0.8 0.4 0.2 0.6 0.5 0.4 0.6 -0.2 0.8 0.9 -0.9 1.1 -0.8 0.0 -1.3
Exposure to tobacco smoke at home 0.9 1.0 2.7 -1.1 1.1 -0.6 -0.9 -1.0 -1.5 -0.9 -1.6 1.1 0.6 1.0 0.0 1.0 0.8 1.1 0.9 1.1 1.4 -1.2 0.5 -1.1 0.2 -0.5
Breastfed as a baby 0.3 0.4 3.4 -0.2 0.1 1.9 -0.1 -0.3 0.3 0.5 -0.3 -0.2 -0.2 0.1 -0.3 -0.2 -0.3 -0.4 0.0 -0.3 0.3 -0.3 -1.8 0.1 -0.1 1.0
Tense / ‘highly strung’ 0.3 0.5 2.2 -0.4 0.0 -0.7 -0.0 -0.5 -0.1 -1.3 -0.4 0.4 -0.9 0.2 1.5 0.3 0.2 0.7 -0.8 0.7 -0.2 -0.7 0.2 -0.8 0.7 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 1.5 0.5 -0.6 0.3 0.7 0.4 1.0 0.2 0.3 -0.5 -1.1 -0.3 -1.0 -0.5 -0.6 0.0 -0.8 -0.3 -0.5 0.4 -1.2 0.2 -0.1 0.4
Hair/balding pattern: Pattern 4 0.1 0.3 2.2 0.2 -0.4 -0.1 0.4 -0.1 0.2 0.7 -0.2 -0.1 -0.1 -0.3 0.0 -0.3 -0.5 -0.2 -1.5 0.2 -1.0 -0.2 -0.2 -0.3 -1.2 -0.3
Birth weight of first child 0.2 0.4 1.8 0.1 -0.5 1.1 0.5 0.0 0.4 -0.6 0.4 0.0 -1.3 -0.1 -0.7 -0.6 -0.5 -0.4 -1.2 -0.4 1.3 -0.3 -0.8 0.3 -0.1 -0.2
Peak expiratory flow (PEF) 0.1 0.2 0.8 -0.2 -0.1 -0.4 -0.1 -0.4 -0.6 0.5 -0.3 -0.9 -0.2 -0.2 -0.1 0.2 0.1 0.1 -0.7 0.4 0.2 -0.6 0.5 -0.4 -0.7 -0.4
Pulse wave reflection index 0.5 0.6 1.7 1.2 0.1 -0.6 0.8 0.8 1.1 0.7 1.0 -0.9 -0.1 -0.8 -0.4 -0.3 -0.6 -0.0 -0.7 -0.6 -0.3 1.3 -0.1 0.9 -1.0 0.8
Ever highly irritable/argumentative for 2 days 0.2 0.2 1.1 0.2 -0.2 -0.2 -0.1 0.7 0.1 1.0 0.3 -0.5 0.4 -0.6 0.3 -0.2 -0.0 -0.5 0.5 -0.4 -1.0 0.7 0.2 0.5 -0.0 0.7
Loud music exposure frequency 0.3 0.3 1.9 -0.1 -0.3 0.2 -0.4 0.2 -0.6 -0.5 -0.2 -0.9 -0.6 -0.1 0.6 -0.1 0.2 -0.4 0.9 -0.3 -1.4 0.2 0.2 0.4 0.9 -0.0
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 3.1 -0.2 0.5 0.2 -0.6 -0.1 0.4 -0.5 -0.5 0.2 -0.2 0.3 0.5 0.4 0.6 0.5 0.5 0.4 1.8 -0.1 0.5 -0.4 0.2 -0.9
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 2.0 -0.3 0.0 0.9 0.2 -0.7 -0.0 0.1 0.1 -0.5 0.9 0.1 -0.3 0.3 -0.2 0.1 0.3 -0.2 -0.2 -0.7 -1.4 0.2 0.8 1.0
Blood clot in the leg (DVT) 1.7 2.2 5.8 -1.8 1.3 -0.1 -1.8 -1.5 -1.6 -2.4 -1.8 0.1 0.0 2.1 1.6 1.4 1.8 1.0 0.1 1.3 1.9 -1.8 1.4 -1.4 1.5 -1.3
Medication: Paracetamol 0.6 1.0 7.8 -0.3 1.3 -0.9 -0.3 -0.2 -0.4 -0.5 -0.6 -0.5 2.8 -0.6 1.0 1.2 0.4 0.9 1.7 0.6 -0.2 -0.2 -0.2 -0.3 0.8 1.7
Headache pain in last month 0.5 0.8 2.1 0.9 -1.1 -0.3 0.9 1.1 1.3 0.9 1.2 -0.9 -1.2 -0.5 0.2 -1.1 -1.0 -1.5 -1.0 -1.0 -0.3 0.9 -0.1 0.8 -0.2 0.2
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.5 0.2 -0.7 0.8 0.4 -0.2 1.2 1.1 0.9 -0.6 -0.4 0.0 0.0 -0.5 -0.7 -0.7 -0.3 -0.4 -0.2 0.1 -1.2 0.1 -0.2 0.2
Glaucoma (self-reported) 0.3 0.3 1.3 -0.8 0.5 -0.1 -0.5 -0.5 -1.0 0.1 -0.5 0.7 0.7 0.4 0.3 0.1 0.4 0.1 0.6 0.4 -0.2 -0.7 1.1 -0.4 0.9 -0.8
Gout (self-reported) 0.8 1.1 5.1 -0.7 0.3 -1.8 -0.8 -0.5 -2.3 -0.1 -0.7 -1.0 0.4 0.3 1.7 0.9 0.8 1.4 -0.3 1.3 0.2 -0.4 1.4 -1.3 -0.7 -0.8
Hypothyroidism/myxoedema (self-reported) 6.1 11.9 19.5 4.0 -3.8 2.7 3.9 4.3 1.9 2.8 3.8 -3.0 -2.5 -3.9 -2.8 -4.2 -4.0 -3.8 -2.0 -4.4 -2.5 4.2 -2.2 4.4 -3.1 3.0
Medication: Amlodipine 0.4 0.6 1.6 -0.8 0.3 -1.2 -0.7 -0.5 -1.2 -0.6 -0.8 0.7 0.7 0.4 -0.0 0.4 0.6 0.5 1.0 1.0 0.4 -0.7 0.9 -0.9 -0.4 -1.3
Medication: Ventolin 100micrograms inhaler 0.5 0.7 3.2 0.1 -0.9 1.8 0.2 0.4 -0.6 -0.3 1.1 -1.8 -0.7 -0.2 -0.8 -0.7 -0.6 -0.5 0.8 -1.0 0.1 0.3 -0.2 1.2 -0.9 0.8
Birth weight 0.5 1.0 3.3 -1.0 1.0 -1.0 -0.7 -1.0 -0.1 -1.1 -0.3 0.8 0.4 0.7 1.1 0.9 0.8 1.5 0.4 1.2 1.8 -1.1 0.8 -1.2 -0.2 -1.5
Chronic bronchitis/emphysema (mother) 0.3 0.4 3.6 -0.0 -0.6 0.6 -0.3 -0.2 -0.1 -1.0 -0.3 -1.2 -1.9 0.0 0.8 0.3 0.3 1.0 -0.2 -0.2 -0.2 -0.0 -0.0 0.3 0.1 0.6
High blood pressure (siblings) 0.6 0.9 3.8 0.9 -0.5 0.7 0.9 1.2 1.3 0.6 1.0 -1.0 -0.5 -1.0 -1.9 -0.8 -0.8 -0.8 -0.2 -0.9 -1.0 1.0 -0.8 1.0 -0.9 1.0
Forced vital capacity (FVC), Best measure 0.0 0.1 0.5 -0.1 0.3 -0.1 -0.0 -0.1 -0.4 0.2 0.1 -0.7 0.2 -0.5 0.1 0.2 -0.1 -0.7 0.7 -0.1 -0.1 -0.2 0.0 0.1 -0.7 0.3
Body fat percentage 0.1 0.4 2.0 -0.1 0.1 -1.0 0.2 -0.3 0.0 1.4 -0.1 0.4 0.3 -0.1 0.1 0.4 0.0 0.5 -1.2 0.6 -0.0 -0.2 -0.6 -0.6 -1.4 0.3
Leg fat percentage (right) 0.1 0.4 3.1 -0.2 0.2 -1.0 -0.1 -0.2 -0.0 1.3 -0.1 0.5 1.0 -0.1 0.3 0.6 0.3 0.7 -0.2 0.8 0.1 -0.1 -0.4 -0.7 -1.8 0.4
Arm fat-free mass (right) 0.3 1.6 4.3 -1.5 1.8 -1.0 -1.5 -1.3 -0.7 -0.2 -0.8 0.9 1.6 1.0 0.9 1.7 1.6 1.3 0.8 1.2 1.7 -1.4 2.1 -1.0 0.7 -0.7
Exposure to tobacco smoke outside home 0.1 0.2 0.7 -0.3 0.5 0.3 -0.2 -0.5 0.7 -0.4 -0.4 0.5 0.7 0.4 -0.8 0.5 0.3 0.1 0.1 0.2 -0.5 -0.4 -0.0 -0.1 0.5 0.2
Comparative body size at age 10 0.2 0.7 5.4 1.0 -0.4 0.0 0.9 1.0 2.3 0.7 0.5 0.3 -0.0 -0.4 -0.2 -1.0 -0.9 -0.7 -0.1 -1.0 -0.1 1.1 -0.6 1.0 -0.7 -0.0
Number of full brothers 1.9 2.4 6.5 -1.8 2.1 0.2 -1.9 -1.6 -0.6 -1.2 -1.9 1.9 1.9 1.6 0.5 1.7 1.7 0.8 1.3 1.1 2.0 -1.9 0.8 -1.1 2.6 0.2
Worry too long after embarrassment 0.4 0.6 1.9 -1.0 0.6 0.3 -0.8 -1.3 -0.8 -0.6 -0.7 0.1 -0.6 0.8 1.1 0.9 0.7 0.4 -0.6 0.9 0.5 -1.4 0.1 -0.8 -0.6 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 1.9 -0.1 0.6 -1.4 -0.0 0.1 -0.2 0.2 0.3 0.6 0.9 0.2 0.1 0.3 0.3 1.0 0.4 0.5 0.2 -0.1 0.1 -0.6 0.0 -0.9
Wheeze or whistling in the chest in last year 0.2 0.3 2.2 0.4 -0.2 -0.6 0.3 1.1 0.5 0.7 0.5 -0.3 0.2 -0.7 -0.1 -0.4 -0.2 -0.0 1.5 -0.2 -0.3 0.7 0.2 0.3 0.4 0.2
Number of children fathered 0.2 0.2 1.0 0.6 -0.4 0.1 0.4 0.6 -0.6 0.1 0.4 0.3 0.3 -0.2 0.4 -0.5 -0.3 -0.5 -1.0 -0.4 -0.4 0.7 -0.2 0.4 -0.5 0.0
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 2.2 0.0 0.2 0.2 -0.1 0.2 0.3 -0.3 -0.2 -0.4 0.1 -0.0 0.1 0.1 -0.0 -0.3 0.5 -0.3 -0.2 0.1 -0.5 0.4 1.5 0.7
Age at first live birth 0.4 0.6 2.8 -0.6 0.6 -1.0 -0.9 -0.3 -1.2 -0.1 -0.2 -1.2 0.9 0.1 -0.4 0.9 0.7 0.9 1.7 0.5 0.1 -0.4 1.3 -0.3 -0.9 0.6
Pulse wave peak to peak time 0.2 0.2 1.3 -0.3 -0.4 0.1 -0.3 0.1 -1.2 -0.5 -0.2 -0.2 -0.1 0.1 1.0 0.0 0.2 -0.3 0.5 -0.1 -0.4 -0.3 -0.3 -0.0 0.9 0.0
Health satisfaction 1.6 2.1 4.4 -1.8 1.6 -0.7 -2.0 -1.6 -1.7 -0.6 -1.3 1.2 1.1 1.8 2.1 1.9 1.9 1.2 1.3 1.7 0.6 -1.7 1.5 -1.5 0.6 -0.5
Shortness of breath walking on level ground 0.2 0.2 1.2 -0.6 0.3 0.4 -0.5 -0.5 -0.4 0.3 -0.8 0.2 0.2 0.2 0.1 0.4 0.4 0.3 0.6 0.0 0.3 -0.3 0.7 -0.0 0.1 1.1
Qualifications: College or University degree 0.8 2.6 7.1 -1.6 1.7 -1.3 -1.9 -1.5 -1.8 -2.6 -1.8 0.4 1.4 1.7 0.3 1.5 1.8 1.0 2.2 1.3 1.7 -1.5 2.7 -0.9 0.9 -1.4
Eye problems/disorders: None of the above 0.5 0.6 3.8 1.1 -0.2 -0.8 1.0 0.6 1.9 1.4 0.4 0.1 0.2 -0.8 -0.7 -0.3 -0.5 0.6 -0.3 -0.2 -0.5 1.0 -0.3 0.1 -0.8 -0.1
Mouth/teeth dental problems: Loose teeth 2.1 2.5 5.7 -1.6 1.6 -2.4 -1.6 -1.2 -2.1 -1.5 -1.3 1.3 1.4 1.4 1.9 1.8 1.7 1.6 0.5 2.1 0.8 -1.3 1.3 -2.0 0.9 -1.7
Emphysema/chronic bronchitis 0.2 0.2 1.1 0.2 0.2 -1.0 -0.0 0.4 0.1 -0.0 0.1 0.4 1.0 -0.1 0.3 0.2 0.3 0.2 1.1 0.3 0.2 0.4 0.4 -0.1 0.2 -0.8
Medication for pain relief, constipation, heartburn 0.3 0.4 2.0 0.2 -0.9 -0.8 0.2 0.1 0.4 0.6 0.5 0.6 -1.1 0.2 -0.8 -0.6 -0.3 -0.2 -0.9 -0.0 0.9 0.1 0.6 -0.2 -0.8 -1.4
Neck or shoulder pain in last month 0.3 0.4 1.4 0.3 -0.7 1.0 0.4 0.3 0.9 0.8 0.6 -1.0 -0.4 -0.8 0.0 -0.1 -0.5 -0.4 0.4 -0.5 -1.0 0.1 -1.2 0.5 -0.5 1.0
Medication: Blood pressure 0.6 1.0 3.1 -0.8 1.1 -1.8 -0.9 -0.6 -1.1 -0.7 -1.0 0.7 1.0 0.3 0.4 1.4 1.2 1.4 1.0 1.2 0.4 -0.9 1.5 -0.8 0.3 -0.2
Angina (self-reported) 0.4 0.5 1.2 0.9 -0.7 0.5 1.1 0.9 0.8 1.1 0.6 -0.1 -0.2 -0.8 -0.4 -0.9 -0.9 -0.2 -0.7 -0.8 -0.5 0.7 -0.7 0.8 0.4 0.5
Migraine (self-reported) 0.2 0.2 1.0 0.0 0.1 0.9 -0.1 -0.1 0.8 0.5 -0.2 0.2 -0.3 0.5 0.5 -0.2 -0.1 -1.0 0.1 -0.2 0.5 0.0 -0.4 0.1 0.5 0.2
Medication: Ibuprofen 0.3 0.3 1.1 0.4 -0.2 0.5 0.3 0.5 0.7 -0.3 0.2 -0.5 -0.2 -0.4 -1.1 -0.4 -0.5 -0.6 -0.4 -0.8 -1.0 0.5 -0.4 0.9 0.4 1.0
Medication: Allopurinol 0.8 1.1 3.4 -0.7 0.3 -1.8 -0.8 -0.5 -1.8 -0.7 -0.8 -0.6 0.2 0.6 1.4 0.8 1.0 1.4 -0.4 1.4 0.2 -0.3 1.5 -1.3 -1.2 -1.2
Medication: Omeprazole 0.5 0.5 3.5 -0.1 -0.1 1.8 0.2 -0.4 -0.3 0.1 0.1 -0.7 -0.5 0.1 1.1 -0.2 -0.6 -1.0 0.1 -0.4 -0.0 -0.7 -1.9 0.2 0.6 1.0
Medication: Seretide 50 evohaler 0.3 0.4 3.1 0.5 -0.5 -0.1 0.9 0.2 0.2 0.4 0.7 -0.1 0.1 -0.4 -0.8 -0.5 -0.8 -0.1 0.5 -0.1 -0.8 0.2 -1.8 -0.1 0.7 -0.1
Mean time to correctly identify matches 0.3 0.6 1.8 -0.5 0.9 -0.9 -0.4 -0.7 0.1 -1.3 -1.0 1.3 0.9 0.6 -0.0 0.9 0.7 1.1 0.8 0.8 0.2 -0.6 0.2 -0.5 1.4 -0.7
Heart disease (mother) 0.3 0.4 2.0 -0.4 0.3 -0.9 -0.5 -0.0 -0.6 -0.7 0.0 0.4 -0.6 0.5 1.3 -0.0 0.4 0.3 -0.2 0.6 -0.4 -0.4 0.8 -0.6 0.7 -1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 2.0 0.4 -1.0 0.2 0.4 0.6 -0.2 0.3 0.5 -1.2 -1.4 0.1 -0.2 -0.8 -0.4 -0.6 -0.7 -0.6 -0.4 0.6 0.1 0.6 0.0 -0.4
Whole body fat mass 0.1 0.5 1.6 -0.5 0.6 -1.3 -0.2 -0.6 -0.1 1.2 -0.4 0.5 0.5 0.1 0.1 0.8 0.5 0.9 -1.1 0.8 0.5 -0.5 0.2 -0.8 -1.1 0.0
Leg fat mass (right) 0.1 0.4 1.9 -0.2 0.4 -1.1 -0.1 -0.2 0.0 1.4 -0.1 0.3 0.8 -0.1 0.2 0.6 0.3 0.7 -0.6 0.6 0.4 -0.1 0.2 -0.6 -1.4 0.3
Arm predicted mass (right) 0.4 1.9 5.3 -1.6 1.9 -1.1 -1.6 -1.4 -1.0 -0.3 -0.9 1.0 1.6 1.2 0.9 1.9 1.7 1.5 0.7 1.3 1.7 -1.5 2.3 -1.1 0.5 -0.8
Pulse rate, automated reading 0.5 1.5 4.8 1.5 -0.8 0.6 1.0 1.6 1.9 0.8 0.4 -1.3 -0.3 -2.0 -2.0 -0.6 -0.7 -0.3 -0.1 -1.1 -0.6 1.8 0.2 1.5 -0.4 2.2
Alcohol intake frequency. 0.2 0.4 1.5 -0.7 0.6 1.2 -0.5 -1.0 0.0 -1.0 -0.8 0.1 -0.1 0.5 0.9 0.5 0.4 0.7 0.5 0.1 0.8 -0.9 -0.4 -0.3 0.5 0.4
Comparative height size at age 10 0.4 2.1 6.2 -1.3 1.4 -2.3 -1.3 -1.1 0.1 -1.3 -1.8 0.5 -0.2 1.0 0.8 1.6 1.7 1.7 -0.4 1.3 2.0 -1.0 1.9 -1.1 2.5 -1.6
Number of full sisters 0.4 0.5 2.3 -0.7 0.8 0.5 -0.5 -0.9 -0.3 -0.7 -0.6 -0.6 0.9 1.0 0.9 0.6 0.5 0.3 0.2 0.2 1.0 -0.9 -0.7 -0.2 1.5 0.2
Suffer from ‘nerves’ 0.3 0.5 2.4 0.6 -0.9 -0.1 0.7 0.6 1.4 -0.1 0.9 -0.6 -1.6 -0.3 -0.1 -0.6 -0.7 -0.1 -1.1 -0.4 -0.3 0.5 -1.4 0.2 -0.1 -0.2
Overall health rating 0.6 1.4 3.4 -1.3 0.9 -0.6 -1.2 -1.2 -1.5 -0.2 -1.1 0.1 1.4 0.9 1.8 1.4 1.3 1.8 1.9 1.3 0.5 -1.3 0.4 -1.3 0.7 -0.3
Chest pain or discomfort 1.3 1.8 4.2 -1.4 1.7 0.9 -1.4 -1.4 -1.9 -1.5 -1.1 1.4 1.8 1.3 1.4 1.3 1.3 0.7 1.8 0.9 0.9 -1.6 0.6 -0.8 2.0 0.1
Had major operations 2.2 2.5 11.1 -1.4 2.1 -0.7 -1.5 -1.0 0.2 -1.7 -1.2 1.3 3.3 0.7 0.6 1.8 1.6 1.8 2.8 1.1 1.1 -1.4 1.6 -0.7 2.4 -0.2
Age at last live birth 1.7 2.5 10.2 1.6 -1.2 0.3 1.2 2.0 0.2 1.6 1.7 -3.2 -0.2 -2.0 -1.5 -1.2 -1.3 -0.9 -0.2 -1.4 -1.6 1.7 -0.3 1.5 -2.6 2.2
Family relationship satisfaction 1.2 1.4 4.6 -1.5 0.3 0.2 -1.8 -1.2 -1.8 -1.0 -0.7 -0.2 -0.5 1.9 2.1 1.1 1.3 0.7 1.2 0.9 0.8 -1.5 1.2 -0.9 0.5 -1.0
Leg pain on walking 0.6 0.7 3.1 0.0 -0.7 1.8 0.5 0.2 -0.5 1.3 0.9 -0.2 -0.4 -0.3 1.1 -1.0 -0.7 -1.6 -1.6 -0.6 -0.3 -0.1 -0.7 0.4 -0.7 0.4
Qualifications: NVQ or HND or HNC or equivalent 1.7 2.1 5.3 1.5 -1.5 0.8 1.6 1.3 0.9 2.3 1.7 -1.2 -1.2 -1.3 -1.5 -1.2 -1.3 -1.3 -1.8 -1.5 -1.6 1.5 -0.9 1.4 -0.4 1.9
Commuting to job workplace: Car/motor vehicle 0.3 0.4 1.9 -0.2 0.3 -0.9 -0.4 -0.7 -0.5 0.3 -0.6 -1.4 0.5 -0.1 0.5 1.0 0.5 0.8 -0.6 0.8 -0.1 -0.5 0.4 -0.7 -0.7 0.4
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 3.8 -0.2 -1.1 1.9 -0.1 -0.6 1.3 1.0 -0.2 0.2 -2.0 0.2 -0.2 -0.6 -0.3 -1.5 -0.6 -0.3 0.1 -0.7 -0.4 0.0 -0.3 0.0
Medication: Aspirin 0.2 0.3 2.7 0.2 -0.0 1.6 0.3 0.3 -0.1 -0.0 -0.4 -0.5 0.2 -0.3 -0.5 -0.3 -0.2 -0.1 0.1 -0.6 -0.9 0.3 -0.4 0.6 0.4 1.2
Supplements: Vitamin C 0.4 0.5 3.7 -0.2 -0.2 1.9 0.2 -0.4 0.1 0.3 -0.5 0.3 -0.1 0.0 -1.1 -0.5 -0.5 -0.4 0.1 -0.3 -0.2 -0.5 -1.7 0.1 1.1 0.7
Knee pain experienced in last month 0.1 0.2 2.1 0.2 0.1 -0.0 0.7 0.1 -0.1 1.5 0.5 0.4 0.3 -0.2 -0.9 -0.2 -0.4 0.1 -0.7 0.1 -0.2 -0.1 -0.5 -0.1 -0.3 -0.1
Hypertension (Self-reported) 0.2 0.6 4.0 -0.3 0.3 -1.3 -0.1 -0.2 -0.1 -0.6 -1.1 0.2 1.2 -0.4 -0.9 0.7 0.3 1.4 2.0 0.8 0.3 -0.2 0.0 -0.7 0.7 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 3.0 -1.2 0.5 0.5 -1.0 -1.5 -1.4 -0.2 -0.7 0.4 -0.5 1.6 1.0 0.8 0.8 0.0 0.7 0.7 0.9 -1.7 -0.2 -0.8 0.6 -1.4
Illnesses of father: Heart disease 0.3 0.5 1.9 0.5 -0.3 0.9 0.8 0.3 0.4 0.6 0.6 -0.3 0.5 -0.8 -0.0 -0.8 -0.9 -1.0 -0.1 -0.6 -0.5 0.0 -1.2 0.4 1.4 0.6
Illnesses of siblings: Diabetes 2.5 3.1 5.2 -2.1 1.5 -1.2 -2.0 -2.0 -1.4 -0.9 -2.2 1.5 1.1 1.7 2.1 1.9 2.0 1.7 0.3 2.2 2.1 -2.1 1.7 -2.3 1.1 -1.3
Smoking status: Previous 1.1 1.6 4.3 1.2 -1.3 0.5 1.4 1.9 0.5 1.7 1.9 0.5 -0.1 -1.0 -0.1 -2.1 -1.5 -1.5 -0.9 -1.6 -1.4 1.6 -0.4 1.6 -0.8 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 2.6 0.1 0.5 -0.4 -0.2 0.3 -0.9 -0.2 -0.3 0.2 -0.2 0.4 -0.1 -0.0 0.3 -0.6 0.5 -0.5 0.5 0.4 1.6 0.7 0.4 -0.4
Whole body fat-free mass 0.4 2.0 6.2 -1.6 1.9 -1.3 -1.6 -1.3 -0.9 -0.6 -1.2 0.9 1.2 1.3 0.8 1.9 1.9 1.5 0.6 1.3 2.0 -1.4 2.5 -1.1 1.0 -1.1
Leg fat-free mass (right) 0.3 1.6 4.0 -1.5 1.8 -1.0 -1.5 -1.3 -0.8 -0.5 -1.4 0.6 0.8 1.2 0.6 1.7 1.7 1.3 0.3 1.1 1.9 -1.3 2.0 -1.0 1.3 -0.9
Arm fat percentage (left) 0.1 0.4 3.3 0.1 -0.1 -0.7 0.5 -0.2 0.1 1.7 0.0 -0.0 -0.2 -0.2 -0.1 0.1 -0.3 -0.1 -1.8 0.3 -0.1 -0.1 -1.1 -0.3 -1.1 0.4
Average weekly red wine intake 1.0 1.5 3.2 1.2 -1.7 1.5 1.2 1.1 1.4 0.7 0.9 -1.3 -0.7 -1.6 -1.0 -1.4 -1.4 -1.8 -1.3 -1.5 -0.9 1.0 -1.2 1.5 0.3 0.9
Handedness (chirality/laterality): Left-handed 0.2 0.2 1.5 0.1 -0.4 0.3 0.1 0.1 -0.2 0.8 -0.1 -0.4 0.1 -0.7 0.6 -0.4 -0.4 -0.6 0.3 -0.3 0.5 0.2 -0.2 0.0 -1.2 0.5
Mood swings 0.2 0.3 2.1 -0.4 0.3 -1.5 0.1 -0.4 -0.1 0.6 -0.3 0.6 0.3 0.4 0.4 0.1 0.0 0.9 -0.3 0.5 0.3 -0.7 0.1 -0.7 0.2 -0.8
Loneliness, isolation 1.0 1.4 3.8 -1.1 0.4 -1.9 -0.8 -0.9 -1.7 -0.1 -0.0 1.1 -0.2 1.2 1.8 0.9 1.1 0.9 -0.4 1.4 1.3 -1.1 1.7 -1.6 -0.1 -2.0
Long-standing illness, disability or infirmity 1.1 1.7 3.4 -1.5 1.3 -0.9 -1.7 -1.3 -1.7 -0.9 -1.8 0.5 -0.1 1.4 1.8 1.5 1.6 1.4 0.0 1.1 1.3 -1.3 1.5 -1.0 1.1 -1.0
Ever had bowel cancer screening 0.4 0.5 2.5 -0.5 -0.2 -0.2 -0.5 -0.5 -0.7 0.2 -0.1 -0.4 -1.0 0.6 1.3 0.3 0.4 0.7 -0.7 0.7 -0.1 -0.3 0.3 -0.5 -1.6 -1.4
Diabetes diagnosed by doctor 0.1 0.2 0.9 -0.3 0.5 0.0 -0.4 0.1 -0.5 0.1 -0.9 0.9 0.4 0.2 0.0 0.1 0.4 -0.0 -0.2 0.0 0.1 -0.2 0.8 0.1 0.8 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 2.5 2.7 5.3 1.8 -1.9 0.1 2.0 2.0 1.2 1.6 2.2 -0.9 -0.8 -2.3 -0.5 -2.3 -2.1 -2.0 -1.9 -1.6 -2.0 1.8 -1.1 1.3 -0.8 0.6
Friendships satisfaction 0.3 0.4 1.5 -0.6 -0.2 0.6 -0.7 -0.5 -0.3 -0.3 -0.5 -0.2 -0.7 0.8 1.2 0.3 0.4 0.5 0.7 0.2 1.0 -0.5 -0.2 -0.2 1.2 -0.2
Qualifications: nursing, teaching 0.3 0.5 2.3 0.6 0.3 0.6 0.5 0.1 0.6 0.2 0.3 -0.5 1.5 -0.5 -0.8 -0.2 -0.7 0.5 0.9 -0.9 -0.6 0.3 -0.3 1.0 0.3 1.3
Commuting to job workplace: Walk 0.3 0.4 1.8 -0.3 0.7 0.5 -0.4 0.1 -0.7 -0.9 -0.6 1.3 0.4 0.5 0.2 0.0 0.3 0.3 1.0 0.1 0.7 -0.1 0.2 -0.0 1.2 -0.4
Eye problems/disorders: Cataract 0.9 1.0 2.6 -1.4 0.6 0.4 -1.2 -1.3 -1.5 -1.3 -0.3 -0.2 0.9 1.5 1.4 0.9 0.8 -0.0 0.8 0.9 1.0 -1.6 -0.3 -0.9 0.6 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 3.2 -1.1 1.1 -0.5 -1.3 -1.1 -0.8 0.2 -1.4 0.9 0.6 1.3 1.0 1.3 1.3 0.6 1.0 1.3 0.7 -1.1 0.4 -1.4 1.8 0.1
Medication for cholesterol 1.5 2.3 5.7 1.5 -0.7 1.8 1.2 1.6 1.2 1.1 1.8 -1.5 -0.9 -1.5 -1.1 -1.4 -1.4 -2.3 -0.8 -2.2 -1.3 1.5 -0.7 2.4 -0.8 2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 5.1 -1.1 1.1 -1.8 -1.1 -1.1 -2.3 0.0 -0.4 0.4 1.2 0.7 1.9 1.5 1.3 1.3 -0.5 1.7 1.0 -1.1 1.0 -1.7 -0.1 -0.8
Back pain experienced in last month 0.3 0.5 2.4 -0.8 -0.3 0.6 -0.6 -0.6 -0.2 -0.4 -0.5 -0.1 -1.1 0.7 0.8 0.1 0.3 -0.3 0.3 0.2 0.9 -1.0 0.6 -0.3 1.6 -0.8
Mineral and other dietary supplements 1.4 1.8 5.3 -1.4 1.8 -0.1 -1.7 -1.0 -1.3 -2.2 -1.1 1.4 0.5 1.8 1.3 1.0 1.6 0.8 1.6 0.7 1.2 -0.9 2.3 -0.5 1.4 -0.8
Breast cancer (self-reported) 0.9 1.1 4.2 0.9 -1.4 0.7 1.0 0.7 -1.0 2.1 0.7 -1.8 -1.4 -0.7 -0.5 -0.7 -0.8 -0.3 -1.4 -0.5 -1.0 0.7 -1.2 0.5 -1.4 -0.2
Asthma (self-reported) 0.2 0.4 3.2 -0.2 0.2 0.4 0.0 0.3 0.2 0.5 0.1 0.4 1.2 0.1 -1.1 -0.1 0.1 -0.7 1.8 -0.2 1.0 -0.1 1.1 0.3 0.4 -0.1
Osteoporosis (self-reported) 0.3 0.3 2.1 0.1 -0.4 1.5 0.1 0.0 0.2 -0.4 0.2 -1.0 -0.7 -0.0 -0.8 -0.3 -0.2 -0.4 0.8 -0.6 0.1 -0.4 -0.6 0.5 1.0 0.3
Osteoarthritis (self-reported) 1.6 2.0 4.9 -1.6 1.0 -1.6 -1.3 -1.5 -1.7 -1.8 -1.0 0.5 0.7 2.2 1.4 1.5 1.5 1.3 0.7 1.6 0.4 -1.6 0.3 -1.6 1.8 -2.0
Medication: Aspirin 0.4 0.5 2.9 0.6 -0.3 1.7 0.7 0.7 0.6 0.3 0.0 -0.3 -0.2 -0.4 -0.7 -0.7 -0.6 -0.3 -0.1 -0.8 -1.3 0.7 -0.8 0.8 0.1 1.2
Medication: Gliclazide 2.7 3.0 5.3 1.7 -1.7 2.2 1.5 1.7 0.2 2.0 1.8 -1.7 -0.3 -1.8 -2.2 -1.6 -1.7 -1.9 -1.1 -2.1 -2.0 1.5 -1.3 2.2 -1.8 2.3
Illnesses of father: None of the above (group 1) 0.6 0.8 3.3 -0.8 0.7 -0.7 -1.1 -0.5 0.2 -1.8 -0.8 0.7 -0.2 1.0 0.9 1.1 1.2 0.7 0.7 0.7 0.8 -0.4 1.4 -0.5 0.9 -0.9
Smoking status: Current 2.0 3.2 8.3 -1.4 1.8 -2.9 -1.7 -0.9 -0.3 -1.9 -1.2 1.1 2.6 1.2 1.7 1.9 1.9 2.1 2.5 1.9 0.9 -1.0 2.4 -1.5 2.5 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 1.7 0.2 -0.1 0.4 0.3 -0.2 -0.5 0.2 -0.1 0.0 -0.4 -0.2 -0.4 0.0 -0.3 -0.1 -1.2 0.1 -1.0 -0.1 -1.1 -0.1 -1.3 0.4
Whole body water mass 0.4 2.1 6.2 -1.7 1.9 -1.2 -1.7 -1.4 -1.0 -0.6 -1.3 1.0 1.3 1.4 0.8 1.9 1.9 1.5 0.6 1.4 2.1 -1.5 2.5 -1.1 1.0 -1.1
Leg predicted mass (right) 0.3 1.5 3.9 -1.4 1.7 -0.9 -1.4 -1.2 -0.8 -0.4 -1.3 0.6 0.8 1.2 0.6 1.6 1.6 1.2 0.2 1.0 1.8 -1.2 2.0 -0.9 1.3 -0.9
Arm fat mass (left) 0.1 0.4 2.1 -0.4 0.3 -0.9 0.0 -0.5 -0.0 1.3 -0.2 0.3 0.3 0.2 0.1 0.6 0.2 0.5 -1.4 0.6 0.6 -0.5 -0.3 -0.6 -0.8 0.0
Number of self-reported non-cancer illnesses 0.3 0.6 2.7 -0.8 0.2 -0.4 -0.8 -0.5 -0.8 -0.1 -0.8 -0.5 0.3 0.4 1.2 0.8 0.8 0.7 1.2 0.7 0.5 -0.7 0.0 -0.7 1.6 -1.0
Average weekly champagne plus white wine intake 0.4 0.5 6.0 -0.2 0.5 1.0 -0.4 -0.2 0.7 -0.9 -0.6 0.5 0.4 0.1 0.7 0.1 0.1 -0.6 0.3 -0.6 -0.4 -0.2 -0.2 0.8 2.5 0.4
Miserableness 0.3 0.6 2.0 -0.9 0.1 -0.5 -0.5 -0.8 -1.3 0.9 -0.3 -0.1 0.3 0.6 1.4 0.7 0.6 0.9 -0.7 0.9 0.2 -1.2 0.1 -1.2 0.2 -0.1
Guilty feelings 0.4 0.5 3.7 -0.4 -0.8 1.3 -0.0 -0.2 -0.6 -0.3 0.1 0.2 -1.9 0.1 1.6 -0.5 -0.3 -0.6 -1.0 0.1 -0.4 -0.5 -0.4 -0.3 -0.8 -0.4
Wears glasses or contact lenses 1.0 1.1 4.2 -0.7 1.6 -0.1 -0.7 -1.0 -0.2 -1.3 -0.9 2.0 1.9 1.0 -0.2 1.0 0.8 1.4 1.5 1.1 0.9 -0.9 0.0 -1.0 0.8 -0.3
Ever taken oral contraceptive pill 0.4 0.4 2.6 0.2 -0.1 -1.6 -0.1 0.4 -0.7 0.1 0.6 -1.3 0.8 -0.2 0.1 0.3 0.2 -0.0 0.8 -0.0 0.2 0.5 1.4 0.2 0.3 -0.2
Hearing aid user 0.7 0.7 2.8 0.4 -0.8 1.4 0.4 0.5 0.4 0.6 1.2 -0.4 -0.3 -0.2 -0.2 -0.8 -0.9 -0.6 -0.7 -1.2 -1.6 0.5 -1.2 1.1 0.1 1.7
Mother’s age at death 0.9 1.1 2.9 -0.8 1.4 -1.6 -0.8 -0.8 -0.6 -0.2 -0.7 0.5 1.6 0.7 -0.3 1.4 1.2 1.2 1.7 1.1 0.7 -0.8 1.5 -0.8 0.6 -0.7
Financial situation satisfaction 0.3 0.4 2.0 -0.5 -0.8 1.0 -0.6 -0.2 -1.4 -0.8 0.1 0.0 -1.0 0.5 0.8 -0.1 0.3 -0.4 0.5 -0.1 0.3 -0.5 0.5 0.0 0.4 0.0
Tinnitus: Yes, now most or all of the time 0.8 0.9 7.2 -0.5 1.2 -0.5 -0.4 -0.4 -0.2 -0.3 -0.4 1.8 2.7 0.1 -0.5 0.5 0.5 0.8 1.7 0.5 1.3 -0.4 0.9 -0.5 1.0 -0.3
Commuting to job workplace: Public transport 0.2 0.2 1.5 0.1 -0.6 0.4 0.1 0.3 0.9 0.5 0.1 -0.3 -0.9 -0.5 -1.2 -0.4 -0.3 -0.7 0.2 -0.3 -0.1 0.1 -0.4 0.3 0.5 -0.2
Eye problems/disorders: Glaucoma 0.1 0.2 0.6 0.2 -0.4 -0.4 0.3 0.4 -0.0 0.2 0.2 -0.2 -0.1 -0.6 -0.8 -0.6 -0.4 -0.3 -0.5 -0.3 -0.4 0.3 0.6 0.4 0.6 -0.4
Medication: Blood pressure 0.4 0.7 2.3 -0.5 0.3 -1.4 -0.5 -0.3 -0.8 -0.3 -1.3 0.1 0.6 0.1 -0.7 0.6 0.7 1.5 0.8 1.2 0.8 -0.3 0.7 -1.2 0.0 -1.0
Pain type(s) experienced in last month: Hip pain 1.5 1.9 4.7 -2.1 1.1 0.1 -2.0 -2.1 -1.5 -0.7 -1.0 0.1 0.6 2.0 1.2 1.9 1.8 0.8 0.4 1.5 0.6 -2.2 0.8 -1.4 1.4 -1.1
Supplements: Fish oil (including cod liver oil) 0.9 1.1 5.8 0.8 -1.5 0.2 1.3 0.4 1.5 1.1 0.7 -1.2 -0.6 -1.2 -0.9 -0.7 -1.3 -0.4 -1.5 -0.5 -1.1 0.3 -2.4 0.1 -0.7 0.8
High cholesterol (Self-reported) 0.8 1.5 4.0 1.0 -1.9 0.5 1.4 1.0 -0.4 1.5 1.8 -0.9 -1.0 -1.0 0.2 -1.3 -1.4 -0.9 -2.0 -0.6 -1.7 0.9 -1.2 0.4 -2.0 0.1
Medication: Bendroflumethiazide 0.1 0.2 1.0 -0.3 -0.4 -0.0 -0.2 -0.3 0.0 0.0 -0.7 -0.8 0.4 -0.5 -0.5 0.4 0.2 0.6 1.0 0.7 -0.2 -0.3 -0.3 -0.7 -0.1 0.2
Medication: Paracetamol 0.4 0.6 5.2 0.2 0.7 -0.1 0.3 0.2 0.2 -0.0 -0.2 0.2 2.3 -0.7 0.7 0.2 -0.3 -0.4 1.4 -0.1 -0.3 0.1 -0.4 0.4 0.7 1.7
Medication: Lisinopril 0.3 0.4 3.3 0.4 -0.6 -1.8 0.3 0.6 -0.1 0.5 0.8 0.3 -0.8 -0.5 0.7 -0.3 -0.3 0.3 -0.1 0.0 0.3 0.5 1.3 -0.0 -0.8 -0.3
Medication: Atorvastatin 0.9 1.1 3.6 0.9 -0.8 1.4 0.9 0.7 0.5 0.7 1.1 -1.9 0.6 -1.3 -1.1 -0.8 -1.1 -1.1 -0.3 -1.1 -0.8 0.6 -0.6 1.3 -0.7 1.8
Illnesses of father: High blood pressure 3.1 3.8 5.9 2.2 -2.4 0.4 2.4 2.0 2.2 2.0 2.1 -1.1 -1.9 -2.2 -1.9 -2.3 -2.4 -1.8 -2.3 -1.9 -1.9 1.9 -2.1 1.5 -1.1 1.3
Alcohol drinker status: Never 0.2 0.3 1.1 -0.4 0.3 0.5 -0.2 -0.4 -0.9 -0.7 -0.7 0.8 0.2 0.3 1.1 0.2 0.3 -0.2 -0.1 0.2 1.0 -0.6 0.3 -0.2 0.8 -0.5
Ever smoked 0.9 1.6 5.7 1.2 -1.3 -1.1 1.2 1.9 1.4 2.4 1.7 0.1 -0.3 -1.2 -0.3 -1.6 -1.2 -0.8 -0.9 -1.0 -1.5 1.8 0.3 1.0 -1.1 -0.2
Basal metabolic rate 0.3 1.7 4.7 -1.5 1.7 -1.2 -1.5 -1.3 -0.8 -0.3 -1.1 0.8 1.2 1.2 0.7 1.8 1.7 1.4 0.3 1.2 1.8 -1.3 2.2 -1.0 0.7 -0.9
Leg fat percentage (left) 0.1 0.4 1.6 -0.2 0.4 -0.9 -0.1 -0.4 0.1 1.1 -0.2 0.7 1.2 0.0 0.2 0.8 0.4 1.0 -0.1 0.8 0.0 -0.2 -0.4 -0.7 -1.2 0.5
Arm fat-free mass (left) 0.3 1.7 4.5 -1.5 1.7 -1.1 -1.4 -1.3 -0.9 -0.2 -0.8 1.1 1.6 1.1 0.9 1.8 1.6 1.5 0.5 1.3 1.7 -1.4 2.1 -1.0 0.5 -0.8
Number of operations (self-reported) 0.3 0.4 2.3 -0.5 0.4 -0.7 -0.1 -0.4 -0.6 0.0 -0.7 0.4 1.5 0.3 0.8 0.1 -0.1 -0.0 0.5 0.5 0.5 -1.0 -0.3 -0.6 0.8 -0.8
Average weekly beer plus cider intake 1.1 1.6 3.9 -1.0 1.4 -2.0 -1.2 -1.1 -1.6 -0.5 -1.2 -0.3 1.9 0.3 1.5 1.8 1.3 1.1 1.4 1.3 1.5 -1.1 1.2 -1.0 0.2 -0.3
Irritability 0.6 0.9 2.3 -1.4 1.1 0.0 -1.1 -1.4 -0.2 -0.1 -1.2 1.3 0.2 0.8 1.2 1.1 1.0 1.0 0.6 1.0 1.2 -1.5 0.5 -1.1 0.4 -0.3
Risk taking 0.3 0.4 3.1 -0.2 -0.7 0.2 -0.6 0.1 -0.1 -0.3 0.3 -1.7 -0.8 0.3 1.3 0.1 0.4 -0.2 0.0 -0.2 -0.6 0.0 0.0 0.3 1.1 -0.6
Ever had prostate specific antigen (PSA) test 1.3 1.5 4.4 1.5 -0.9 -0.3 1.1 1.5 1.1 1.3 0.6 -1.4 -1.2 -1.4 -0.7 -1.1 -1.1 -0.9 -2.1 -1.2 -1.6 1.7 -0.6 1.2 -1.0 0.4
Fractured/broken bones in last 5 years 0.5 0.7 3.1 0.1 -0.8 1.8 -0.1 0.3 -0.3 0.9 1.4 -1.1 0.2 -0.5 -0.3 -0.2 -0.1 -1.0 0.8 -0.9 -0.5 0.1 0.5 1.2 -0.1 1.5
Age started oral contraceptive pill 0.4 0.5 3.8 -0.1 0.7 -1.9 -0.0 -0.1 -0.4 -0.2 -0.4 0.8 1.2 -0.1 -0.6 0.5 0.4 1.7 0.6 0.6 0.4 -0.1 0.5 -0.6 0.2 -0.3
Diastolic blood pressure, automated reading 0.1 0.4 4.1 0.1 -0.0 -0.7 0.4 0.0 1.1 0.1 0.0 0.5 1.2 -0.2 -0.8 0.1 -0.2 0.5 2.0 0.3 -0.6 0.2 -0.3 -0.2 0.7 0.2
Ever depressed for a whole week 0.3 0.3 1.1 0.3 -0.7 0.0 0.6 0.5 1.0 0.9 0.7 0.7 -0.1 -0.7 0.5 -0.9 -0.7 -0.9 -0.1 -0.2 -0.4 0.3 -0.0 -0.1 -0.5 -0.1
Unable to work because of sickness or disability 0.3 0.5 1.3 0.8 -0.7 -0.9 0.6 1.0 0.2 0.4 0.3 -1.1 -0.7 -1.0 -0.5 -0.6 -0.5 -0.6 0.3 -0.7 -0.5 1.0 0.2 0.8 -0.3 0.6
Commuting to job workplace: Cycle 1.0 1.2 4.8 -1.1 0.6 -0.1 -1.4 -0.6 -1.2 -1.7 -1.0 0.8 -1.0 1.4 0.2 0.5 1.4 0.5 0.1 0.8 1.1 -0.9 2.2 -0.7 0.5 -1.8
Myopia 0.1 0.2 1.1 0.2 0.2 0.2 -0.1 0.0 0.7 -0.4 0.0 1.1 -0.7 0.5 0.8 -0.0 0.1 -0.2 0.1 -0.0 0.4 0.0 -0.1 0.2 0.6 -0.8
Vascular/heart problems diagnosed by doctor 0.1 0.4 2.5 0.4 -0.2 0.9 0.4 0.3 0.2 0.3 1.1 -0.0 -0.5 0.2 0.6 -0.6 -0.4 -1.1 -1.6 -0.8 -0.1 0.3 -0.1 0.6 -0.1 0.1
Cholesterol lowering medication 0.3 0.4 1.4 -0.6 -0.2 -1.0 0.0 -0.7 -0.5 0.5 0.1 1.1 0.3 0.7 0.7 0.1 0.0 0.8 -0.1 0.9 0.1 -0.7 -0.3 -1.2 -0.0 -1.2
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 2.1 -0.3 0.1 1.5 -0.0 -0.5 -0.4 -0.3 -0.3 -0.1 0.1 0.2 1.2 0.1 -0.2 -0.6 1.0 -0.1 -0.2 -0.8 -1.4 -0.1 0.5 0.7
Pain experienced in last month 1.0 1.6 3.6 1.6 -0.8 0.7 1.5 1.3 1.2 0.9 0.9 -0.4 0.0 -1.6 -1.8 -1.3 -1.4 -0.9 0.1 -1.5 -0.8 1.7 -1.0 1.6 -1.7 1.9
Supplements: Calcium 0.4 0.4 2.5 -0.3 0.0 -0.7 0.0 -0.2 -0.6 0.5 -0.5 0.8 0.6 0.3 1.0 0.0 0.1 0.3 1.6 0.7 0.5 -0.4 -0.5 -1.0 0.3 -0.8
Basal cell carcinoma (self-reported) 0.6 0.7 4.1 0.4 -1.2 -0.1 0.4 0.0 -0.4 -0.0 0.1 -0.8 -1.7 -0.2 1.6 -0.5 -0.6 -0.0 -2.0 -0.3 -1.6 0.2 -0.4 0.1 -0.5 -0.6
Heart attack/myocardial infarction (self-reported) 0.4 0.5 3.3 -0.3 1.4 -0.3 -0.6 0.3 -0.5 -0.7 -0.4 0.5 1.4 0.3 -0.4 0.7 0.9 0.1 1.8 0.5 0.4 -0.3 0.6 -0.2 0.8 0.0
Deep venous thrombosis (DVT) (self-reported) 1.4 1.8 5.3 -1.6 1.2 0.3 -1.6 -1.4 -1.5 -2.3 -1.6 0.1 0.0 1.8 1.2 1.2 1.6 0.8 0.2 1.0 1.8 -1.7 1.1 -1.1 1.6 -0.9
Heart disease (siblings) 0.8 1.0 2.9 -1.2 0.7 -0.2 -1.3 -1.0 -1.6 -1.7 -0.9 0.3 0.2 1.0 1.6 0.9 1.0 0.9 0.0 1.0 1.0 -1.3 0.8 -0.8 -0.2 -0.9
Alcohol drinker status: Previous 0.6 0.6 1.9 0.8 0.0 1.3 0.9 0.7 1.0 0.5 -0.0 0.4 0.2 -0.9 -0.6 -0.8 -0.9 -0.6 -0.4 -1.1 -0.5 0.6 -1.4 1.0 0.3 1.1
Pack years of smoking 3.4 5.0 9.2 -2.0 2.5 -3.0 -1.9 -2.0 -1.2 -2.6 -2.6 2.6 1.6 1.9 2.0 2.4 2.3 2.8 0.7 2.8 2.0 -1.9 2.0 -2.7 2.1 -2.3
Impedance of whole body 0.2 1.2 2.5 1.4 -1.0 0.3 1.4 1.2 1.1 0.7 1.0 -0.8 -0.5 -1.4 -0.7 -1.3 -1.5 -1.0 -0.4 -1.1 -1.6 1.1 -1.6 0.9 0.1 1.0
Leg fat mass (left) 0.1 0.3 1.6 -0.2 0.5 -1.1 -0.1 -0.2 0.1 1.3 -0.1 0.3 0.9 -0.1 0.1 0.7 0.4 0.8 -0.5 0.6 0.3 -0.1 0.2 -0.5 -1.1 0.3
Arm predicted mass (left) 0.4 1.9 5.2 -1.6 1.8 -1.3 -1.5 -1.5 -0.9 -0.4 -1.1 0.9 1.7 1.1 0.9 2.0 1.8 1.7 0.6 1.4 1.7 -1.5 2.3 -1.2 0.7 -0.9