TWAS hub - ATAD1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0900	0.0260	7.6e-07	0.056	0.035	0.034	0.034	0.049	2.0e-07	3.8e-05	4.4e-05	5.0e-05	1.2e-06
2	GTEx	Adipose Subcutaneous	0.1190	0.0360	2.3e-05	0.075	NA	0.080	NA	0.074	1.0e-06	NA	4.0e-07	NA	1.2e-06
3	GTEx	Artery Aorta	0.1430	0.0580	5.7e-03	-0.005	NA	0.006	NA	-0.004	8.6e-01	NA	1.4e-01	NA	6.4e-01
4	GTEx	Breast Mammary Tissue	0.2210	0.0830	3.5e-03	-0.005	NA	0.064	NA	0.020	6.8e-01	NA	3.2e-04	NA	3.0e-02
5	GTEx	Cells Transformed fibroblasts	0.0630	0.0260	5.0e-03	-0.003	NA	-0.003	NA	0.000	6.2e-01	NA	6.0e-01	NA	3.1e-01
6	YFS	Blood	0.0669	0.0157	1.7e-16	0.077	0.051	0.065	0.071	0.074	7.2e-24	3.1e-16	1.6e-20	3.3e-22	4.2e-23
7	TCGA	Brain Lower Grade Glioma	0.0552	0.0277	9.2e-04	0.026	0.009	0.019	NA	0.007	5.5e-04	2.9e-02	2.8e-03	NA	5.1e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	4	5	6	7
Body Mass Index (BMI) (2010)	6.2	8.5	13.0	-3.6	-3.5	-2.9	-0.9	-3.5	-3.6
Vascular/heart problems diagnosed by doctor	4.7	12.8	18.1	3.8	4.3	3.1	3.9	4.1	3.9
Long-standing illness, disability or infirmity	4.6	7.1	10.0	-3.2	-3.1	-2.1	-2.8	-2.9	-3.0
Leg pain on walking	4.4	5.5	8.6	-2.7	-2.8	-2.9	-1.4	-2.7	-2.4
Current tobacco smoking	4.0	6.5	13.7	-2.4	-2.6	-3.2	-1.6	-2.6	-3.7
High blood pressure	3.8	10.6	16.4	-3.3	-3.8	-2.5	-3.4	-3.7	-4.0
Hypertension (Self-reported)	3.7	10.4	15.1	-3.5	-3.9	-2.5	-3.3	-3.8	-3.8
Medication: Blood pressure	3.7	7.0	10.0	-2.8	-3.2	-2.0	-3.0	-3.1	-2.9
Smoking status: Current	3.5	5.6	10.9	-2.2	-2.4	-3.1	-1.4	-2.4	-3.3
Illnesses of father: High blood pressure	3.5	4.4	11.8	-2.2	-2.4	-0.9	-1.5	-2.3	-3.4
Major Depression (MDD)	3.4	4.1	8.1	-2.7	-2.9	-1.5	-0.6	-2.8	-1.8
Guilty feelings	3.4	5.2	9.2	2.9	3.0	1.5	2.2	3.0	1.7
Medication: Aspirin	3.3	4.3	8.4	-2.3	-2.4	-1.5	-2.9	-2.3	-1.8
Frequency of depressed mood in last 2 weeks	3.2	4.5	8.6	2.6	2.7	0.8	2.9	2.6	1.1
Mouth/teeth dental problems: Loose teeth	3.2	3.7	8.9	-2.6	-2.2	-3.0	-0.2	-2.2	-0.5
Chest pain or discomfort	3.2	4.6	7.0	-2.4	-2.6	-2.2	-2.1	-2.6	-2.0
Fasting Glucose	2.8	3.4	5.7	2.0	2.0	2.4	1.9	2.1	1.2
Medication: Aspirin	2.7	3.5	7.3	-2.1	-2.3	-1.0	-2.7	-2.1	-1.6
Medication: Bendroflumethiazide	2.7	4.2	8.6	-2.4	-2.5	-1.6	-0.6	-2.4	-2.9
Medication: Ibuprofen (e.g. Nurofen)	2.6	3.3	7.9	1.7	2.3	1.4	2.8	2.3	0.5
Relative age of first facial hair	2.5	5.2	12.4	2.4	2.6	-0.0	2.4	2.5	3.5
Wears glasses or contact lenses	2.5	2.9	4.8	-2.1	-2.2	-2.1	-1.4	-2.1	-0.5
Relative age voice broke	2.4	3.6	5.7	2.2	2.4	0.8	1.9	2.4	2.2
Number of incorrect matches in round	2.3	3.7	6.3	-2.1	-2.5	-2.1	-2.2	-2.5	-0.1
Diabetes (self-reported)	2.3	3.5	11.6	-2.1	-1.9	-0.9	-1.1	-1.8	-3.4
Age at first live birth	2.3	4.1	7.2	2.7	2.4	2.2	1.9	2.4	1.3
Heart disease (mother)	2.3	2.8	5.1	-1.9	-2.1	-0.9	-1.0	-2.1	-2.2
Depression (Nagel 2018)	2.2	3.3	6.2	2.2	2.2	1.3	2.5	2.2	0.5
Medication: Ramipril	2.2	2.8	8.7	-1.7	-2.0	-0.4	-3.0	-1.9	-0.4
Illnesses of mother	2.2	2.8	5.3	1.6	1.8	1.1	2.0	1.7	2.3
Mouth/teeth dental problems: Dentures	2.1	3.6	13.4	-1.7	-2.2	-0.7	-0.2	-1.9	-3.7
Overall health rating	2.1	4.4	10.2	-2.1	-2.2	-1.8	-3.2	-2.2	-1.8
Medication for cholesterol	2.1	3.2	5.4	2.0	2.3	0.7	2.3	2.2	1.6
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	6.0	1.8	1.8	2.4	0.6	1.7	0.7
Hypothyroidism/myxoedema (self-reported)	2.0	3.8	10.1	-2.3	-2.4	0.2	-3.2	-2.3	-0.6
Forced vital capacity (FVC), Best measure	2.0	7.3	15.0	3.0	2.8	2.7	2.2	2.7	3.9
Tinnitus: Yes, now most or all of the time	2.0	2.3	8.7	-0.8	-0.8	-1.9	1.5	-0.8	-3.0
Systolic blood pressure, automated reading	1.9	5.4	7.2	-2.6	-2.7	-2.3	-2.3	-2.7	-2.5
Medication: Co-codamol	1.9	2.2	4.6	-2.0	-2.1	0.6	-0.8	-2.1	-1.3
Worry too long after embarrassment	1.9	3.1	5.5	2.2	2.1	1.6	2.3	2.1	0.5
Angina (self-reported)	1.9	2.5	4.0	-1.9	-1.9	-0.9	-2.0	-1.8	-1.5
Irritability	1.9	3.2	4.8	2.2	2.2	1.5	2.0	2.2	1.3
Number of treatments/medications taken	1.8	3.2	9.5	-2.0	-2.1	-0.7	-3.1	-2.0	-0.4
Health satisfaction	1.8	2.4	7.4	-1.4	-1.2	-1.5	-2.7	-1.2	-1.4
Emphysema/chronic bronchitis	1.8	2.0	4.2	-2.0	-1.8	-0.7	-1.5	-1.8	-0.9
Commuting to job workplace: Walk	1.8	1.9	8.1	-1.1	-1.4	-0.1	-2.8	-1.4	0.5
High blood pressure (mother)	1.7	2.4	5.9	-1.2	-1.7	0.0	-1.9	-1.6	-2.4
Forced vital capacity (FVC)	1.7	6.5	17.9	2.6	2.5	2.5	1.6	2.4	4.2
Father’s age at death	1.7	2.3	4.3	1.4	1.6	0.9	1.9	1.6	2.1
Commuting to job workplace: Car/motor vehicle	1.7	1.9	3.3	1.6	1.8	1.7	1.2	1.8	0.6
Average weekly champagne plus white wine intake	1.7	2.4	4.3	1.4	1.4	2.1	1.7	1.3	-2.0
Blood Eosinophil Count	1.6	12.0	44.4	-1.8	-2.1	-1.1	-5.2	-1.9	6.7
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	3.5	-1.8	-1.4	-1.6	-1.9	-1.5	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.2	9.0	2.6	2.5	1.8	3.0	2.4	2.4
Loud music exposure frequency	1.6	1.8	2.5	1.5	1.6	1.3	1.0	1.6	1.6
Headache pain in last month	1.6	2.8	7.4	-1.7	-1.9	-0.6	-2.7	-1.9	-1.5
Medication: Blood pressure	1.6	2.9	4.6	-1.7	-2.0	-1.5	-1.4	-2.0	-2.1
Financial situation satisfaction	1.6	2.0	3.9	2.0	2.0	0.9	-0.9	1.9	-0.9
Ever depressed for a whole week	1.6	1.9	3.5	-1.5	-1.6	-1.6	-1.9	-1.5	-0.1
Alzheimer’s Disease (in father)	1.5	1.6	3.0	1.3	1.4	1.7	1.2	1.4	1.2
Smoking Status	1.5	3.6	7.9	-1.6	-1.8	-2.7	-1.0	-1.8	-2.8
Angina	1.5	2.0	3.8	-1.6	-1.6	-0.9	-1.9	-1.5	-1.4
Medication: Atenolol	1.5	1.9	3.4	-1.7	-1.8	1.4	-1.0	-1.7	-1.1
Heart attack	1.5	1.9	4.2	-2.1	-1.9	-0.9	-1.0	-1.7	-0.6
Knee pain experienced in last month	1.5	2.3	3.8	-1.8	-2.0	-1.8	-0.4	-2.0	-1.3
Diabetes diagnosed by doctor	1.5	2.4	8.6	-1.6	-1.4	-1.0	-0.9	-1.4	-2.9
Ever taken oral contraceptive pill	1.5	1.7	6.9	1.4	1.2	0.3	2.6	1.2	-0.3
Number of operations (self-reported)	1.5	2.2	4.1	-1.6	-2.0	-1.8	-1.4	-2.0	-0.0
Risk taking	1.5	2.2	3.6	1.7	1.8	1.6	1.9	1.8	-0.3
Unable to work because of sickness or disability	1.5	1.9	8.7	-1.2	-1.0	-3.0	-1.2	-1.0	-0.3
Cardiovascular Disease	1.4	4.5	7.5	-2.2	-2.6	-1.5	-2.1	-2.5	-2.7
Medication: Amlodipine	1.4	2.0	5.5	-1.7	-1.5	-1.2	-0.2	-1.5	-2.4
Neuroticism (Nagel 2018)	1.3	3.0	4.8	2.2	2.1	1.9	1.3	2.1	1.5
Systolic Blood Pressure	1.3	6.6	12.5	-2.5	-2.7	-2.2	-2.8	-2.8	-3.5
Hypothyroidism (self reported)	1.3	2.9	8.5	-1.9	-2.0	1.0	-2.9	-1.9	-0.1
Other serious medical condition/disability diagnosed by doctor	1.3	1.6	4.5	-1.4	-1.4	1.1	-2.1	-1.2	-0.3
Hearing difficulty/problems with background noise	1.3	2.0	5.2	-1.7	-1.4	-0.9	-1.1	-1.4	-2.3
Mouth/teeth dental problems	1.3	2.0	6.9	1.2	1.7	0.4	0.5	1.5	2.6
Noisy workplace	1.3	1.6	3.0	-1.7	-1.7	-0.1	-0.6	-1.7	-1.5
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.8	-1.5	-1.3	-1.9	-1.1	-1.4	-0.4
Number of self-reported non-cancer illnesses	1.3	2.3	6.9	-1.4	-1.5	-1.2	-2.6	-1.4	-1.2
Heart attack/myocardial infarction (self-reported)	1.3	1.6	3.9	-2.0	-1.8	-0.7	-1.0	-1.6	-0.5
Sensitivity / hurt feelings	1.2	2.1	5.0	2.2	1.9	0.8	0.8	1.8	-1.0
Forced expiratory volume in 1-second (FEV1)	1.2	4.1	7.6	2.2	2.2	1.5	2.3	2.0	2.8
Ulcerative Colitis	1.1	1.6	3.2	1.8	1.7	-0.5	1.3	1.6	0.5
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.5	1.3	1.4	1.1	1.6	1.4	0.3
Medication: Levothyroxine sodium	1.1	1.9	5.8	-1.5	-1.4	1.2	-2.4	-1.3	-0.6
Nervous feelings	1.1	2.0	3.7	1.9	1.8	0.9	1.6	1.7	1.0
Medication: Simvastatin	1.1	1.6	2.8	-1.7	-1.6	-1.2	-1.6	-1.4	-0.2
Time employed in main current job	1.1	1.3	2.7	1.7	1.5	-0.7	-0.8	1.4	0.7
Medication: Ibuprofen	1.1	1.3	3.8	1.0	1.4	0.8	1.9	1.4	0.0
Mean time to correctly identify matches	1.1	2.1	3.9	-2.0	-1.9	-0.8	-1.5	-1.8	1.0
Qualifications: nursing, teaching	1.1	1.8	3.8	1.9	1.7	1.5	0.5	1.7	-0.6
Bipolar Disorder (2018)	1.0	1.6	2.7	-1.3	-1.5	-0.8	-1.5	-1.5	-1.7
Bipolar Disorder or Schizophrenia	1.0	2.4	3.7	-1.9	-1.9	-1.5	-1.9	-1.8	-0.8
Prostate Cancer	1.0	1.4	3.2	-1.1	-0.8	-1.7	0.7	-0.9	-1.8
Coronary Artery Disease (CAD)	1.0	1.2	3.4	-1.0	-1.2	-1.3	-1.9	-1.1	-0.4
Fluid intelligence score	1.0	2.0	3.5	1.5	1.6	1.0	1.9	1.5	1.6
Tense / ‘highly strung’	1.0	1.7	4.0	-0.9	-1.4	-1.1	-1.2	-1.5	2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	3.2	-1.4	-1.7	-0.7	-1.2	-1.8	-1.0
Medication: Seretide 50 evohaler	1.0	1.2	2.7	-1.5	-1.0	-1.0	-1.6	-1.0	0.1
Pulse rate, automated reading	1.0	3.1	11.7	-1.2	-1.4	-1.9	-1.1	-1.5	-3.4
Pack years of smoking	1.0	1.4	3.5	-1.4	-1.4	-1.9	-0.2	-1.5	-0.5
Rheumatoid Arthritis	0.9	1.2	2.6	-1.1	-1.2	-1.2	-1.6	-1.2	0.4
Neuroticism	0.9	2.1	3.6	1.8	1.9	1.7	1.2	1.9	0.4
Multivitamins +/- minerals	0.9	1.2	1.8	-1.2	-1.3	0.4	-1.0	-1.4	-1.4
Chronic bronchitis/emphysema (father)	0.9	1.1	2.2	-1.5	-1.3	-0.4	-1.4	-1.1	-0.4
Asthma	0.9	1.8	3.6	-1.6	-1.6	-1.1	-1.9	-1.6	0.2
Depression (self-reported)	0.9	1.1	1.5	-1.2	-1.1	-1.2	-1.2	-1.2	1.1
Prospective memory result	0.9	1.1	4.7	-0.9	-1.0	-2.2	-0.5	-0.9	-0.4
Chronic bronchitis/emphysema (mother)	0.9	1.1	3.8	-1.1	-0.9	-0.2	-2.0	-0.9	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	5.1	-0.9	-0.9	-0.2	-2.3	-0.9	0.3
Wheeze or whistling in the chest in last year	0.9	1.6	2.8	-1.1	-1.4	-1.1	-1.5	-1.4	-1.7
Medication: Gliclazide	0.9	1.1	4.9	-1.1	-0.7	-0.5	-0.4	-0.7	-2.2
Hearing aid user	0.9	1.0	3.4	-0.4	-0.8	-1.9	0.0	-0.8	-1.4
Schizophrenia (2014)	0.8	1.7	3.2	-1.5	-1.5	-1.5	-1.8	-1.4	-0.5
Height	0.8	16.2	41.5	4.2	3.9	4.8	1.2	3.8	6.4
Taking other prescription medications	0.8	1.3	5.9	-0.6	-0.7	1.1	-2.4	-0.6	0.7
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.1	-1.4	-1.3	-0.1	0.3	-1.2	-0.9
Impedance of arm (right)	0.8	3.9	7.6	2.8	2.4	0.2	1.2	2.4	2.5
Happiness	0.8	1.0	3.9	1.0	0.9	0.4	-0.6	0.9	2.0
Medication: Lansoprazole	0.8	0.9	3.6	-0.7	-0.7	1.1	-1.9	-0.6	0.4
Impedance of arm (left)	0.8	3.6	6.6	2.6	2.3	0.0	1.6	2.3	2.4
Birth weight of first child	0.8	1.5	3.9	1.6	1.2	0.8	0.2	1.3	2.0
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.4	1.2	1.3	1.6	1.3	1.3	-0.4
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	2.3	1.2	1.4	1.5	0.4	1.3	1.5
Glaucoma (self-reported)	0.8	0.9	3.8	-0.7	-0.9	-0.4	-2.0	-0.9	-0.4
Asthma (self-reported)	0.8	1.7	3.3	-1.5	-1.5	-1.1	-1.8	-1.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	3.0	1.4	1.5	1.5	1.7	1.4	0.7
Supplements: Calcium	0.8	0.9	3.6	0.3	0.2	0.7	-1.5	0.2	1.9
Depressed Affect (Nagel 2018)	0.7	1.4	2.9	1.4	1.6	0.4	1.3	1.7	0.6
Age at First Birth	0.7	1.0	1.6	1.1	1.0	1.3	0.9	1.0	1.2
Mean Putamen Volume	0.7	0.8	1.4	-1.2	-0.9	1.0	-1.0	-0.9	0.4
Blood White Count	0.7	5.4	10.4	-2.5	-2.8	-3.2	-1.8	-2.7	-1.6
Type 2 Diabetes (T2D) (2018)	0.7	1.2	4.0	-1.4	-1.1	-0.6	0.0	-1.0	-2.0
Pack years adult smoking proportion	0.7	1.1	2.4	-1.2	-1.3	-1.6	-0.1	-1.4	-0.5
Hand grip strength (right)	0.7	1.8	4.9	1.4	1.3	1.5	2.2	1.2	0.5
Average weekly fortified wine intake	0.7	0.8	1.6	0.7	1.1	1.3	1.1	1.0	-0.1
Fed-up feelings	0.7	1.3	2.2	1.2	1.4	0.4	1.5	1.5	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	6.0	-0.4	-0.0	-0.1	2.5	0.1	-2.2
Had other major operations	0.7	0.9	1.6	-1.0	-1.1	-1.2	-0.9	-1.1	-0.5
Qualifications: None of the above	0.7	1.4	2.6	-1.5	-1.6	-1.0	-1.3	-1.4	-0.4
Financial difficulties in last 2 years	0.7	0.9	3.9	0.8	0.5	-0.4	0.9	0.6	-2.0
Illnesses of siblings	0.7	0.9	2.3	-0.4	-0.2	-1.4	-1.4	-0.2	1.5
Medication: Cholesterol lowering	0.7	1.1	1.9	-1.2	-1.1	-1.3	0.0	-1.0	-1.4
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.5	-1.0	-0.8	-0.1	-0.7	-0.7	1.9
Number of children fathered	0.7	0.8	1.3	1.0	1.1	0.3	0.9	1.0	1.1
Neck or shoulder pain in last month	0.7	1.1	2.0	1.1	1.3	1.4	-0.6	1.4	-0.4
Alcohol intake frequency.	0.7	1.5	7.3	-0.8	-1.0	-0.1	-0.9	-1.0	-2.7
Comparative height size at age 10	0.7	3.8	6.9	2.1	2.2	2.3	0.9	2.1	2.6
Age at last live birth	0.7	1.0	2.7	1.2	0.8	1.6	0.7	0.8	1.0
Handedness (chirality/laterality): Left-handed	0.7	0.9	3.0	-0.3	-0.4	-1.7	-0.0	-0.5	1.7
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.7	1.3	1.1	1.6	0.8	1.2	-0.0
Schizophrenia (2018)	0.6	1.2	2.1	-1.4	-1.2	-1.3	-1.3	-1.1	0.3
Ulcerative Colitis (UC)	0.6	1.2	2.1	1.4	1.5	-0.5	1.1	1.4	0.9
Neuroticism (2016)	0.6	0.8	1.7	0.8	0.9	-0.6	1.3	0.9	1.1
Heel T-Score	0.6	4.6	10.8	-3.0	-2.0	-0.2	2.1	-2.0	-3.3
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.0	-0.9	-1.1	-1.4	-0.2	-1.0	-0.1
Diabetes (father)	0.6	0.7	3.4	0.6	0.7	1.9	0.2	0.6	-0.5
Severe depression (siblings)	0.6	0.7	1.9	-1.0	-0.9	-1.4	-0.2	-0.9	0.4
Townsend deprivation index at recruitment	0.6	0.8	3.3	-0.2	-0.2	0.7	-1.3	-0.2	-1.8
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.9	0.6	0.4	1.4	-1.1	0.5	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.9	0.9	1.2	-0.6	1.4	1.2	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	6.7	-0.3	0.1	-0.2	2.6	0.1	-1.4
Neuroticism score	0.6	1.2	2.4	1.6	1.5	0.4	1.2	1.4	0.4
Hair/balding pattern: Pattern 3	0.6	0.9	5.5	-0.2	-0.3	-0.5	-2.3	-0.2	-0.5
Standing height	0.6	5.7	23.0	2.1	1.9	2.2	-0.4	1.9	4.8
Breastfed as a baby	0.6	0.8	1.5	0.8	0.9	1.2	1.1	0.9	0.7
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.7	-0.5	-0.3	-1.1	-1.2	-0.4	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	4.0	-0.5	-0.6	-2.0	0.3	-0.5	0.0
Qualifications: College or University degree	0.6	2.0	4.0	1.5	1.6	2.0	1.4	1.4	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.4	0.9	1.2	0.1	1.0	1.1	0.6
Average weekly red wine intake	0.6	0.9	2.0	0.6	0.9	-0.5	1.4	0.9	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.1	0.3	0.2	-1.4	-0.1	0.2	1.4
Friendships satisfaction	0.6	0.7	1.8	-0.4	-0.8	-1.3	-1.2	-0.8	0.8
Back pain experienced in last month	0.6	0.9	3.4	-0.2	-0.6	-1.9	0.2	-0.5	-1.5
Medication: Lisinopril	0.6	0.8	1.3	-0.7	-0.9	-1.2	-1.0	-0.8	-1.1
Fractured/broken bones in last 5 years	0.6	0.7	1.4	1.0	1.0	-0.4	1.2	1.0	0.8
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.9	-0.8	-0.9	0.1	-1.4	-0.8	-1.0
Impedance of whole body	0.6	3.0	6.6	2.6	2.3	0.1	1.5	2.2	1.5
Reaction Time	0.5	0.9	1.7	-1.3	-1.2	-0.8	-0.9	-1.1	0.5
Verbal and Numeric Reasoning (VNR)	0.5	1.1	3.1	1.1	1.2	0.6	0.7	1.2	1.8
Primary Biliary Cirrhosis	0.5	0.7	1.9	0.6	0.6	1.4	1.1	0.6	0.9
Blood Platelet Count	0.5	6.3	38.3	0.4	0.4	0.1	2.4	0.1	-6.2
Respiratory disease	0.5	1.0	3.3	-0.9	-1.1	-0.6	-1.8	-1.1	0.6
Lung FEV1/FVC ratio	0.5	2.6	6.7	-0.8	-0.3	-2.3	2.3	-0.2	-2.6
Hand grip strength (left)	0.5	1.2	4.0	0.9	0.9	1.3	2.0	0.8	0.5
Ever had hysterectomy (womb removed)	0.5	0.6	1.5	-0.9	-0.8	-1.2	-0.4	-0.8	-0.3
Vitamin and mineral supplements	0.5	0.6	3.3	0.2	0.6	0.1	1.8	0.6	0.6
Supplements: Zinc	0.5	0.5	1.7	0.6	0.4	-0.2	1.1	0.3	1.3
Maternal smoking around birth	0.5	0.7	2.1	0.8	1.0	-0.2	1.5	0.9	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.5	-0.1	0.2	-1.5	0.3	0.2	-1.6
Alcohol intake versus 10 years previously	0.5	0.8	4.8	-0.3	-0.4	-0.5	-0.6	-0.4	-2.2
Worrier / anxious feelings	0.5	0.9	2.0	-0.6	-1.1	-1.4	-1.2	-1.1	0.1
Length of working week for main job	0.5	0.5	1.4	-0.7	-0.5	-1.1	-0.2	-0.5	-1.2
Medication: Omeprazole	0.5	0.5	1.3	-0.7	-0.8	-0.0	-1.1	-0.7	-1.0
Family relationship satisfaction	0.5	0.6	3.0	-0.5	-0.6	-1.7	-0.3	-0.6	0.1
Medication: Paracetamol	0.5	0.8	2.4	-0.9	-1.1	-0.3	-1.6	-1.1	-0.3
Medication: Atorvastatin	0.5	0.6	4.1	0.4	0.1	-0.2	-0.4	0.1	-2.0
Leg fat percentage (left)	0.5	1.8	9.1	-0.8	-0.7	-0.7	1.2	-0.6	-3.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.6	-0.1	-0.3	-1.6	0.9	-0.4	0.7
Pain experienced in last month	0.5	0.8	1.7	0.6	0.8	0.8	1.3	0.8	1.3
Ovarian Cancer	0.4	0.5	2.1	0.7	0.6	0.4	1.4	0.7	0.1
Triglycerides	0.4	0.7	2.2	-0.6	-0.7	-1.5	-0.1	-0.7	-1.1
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.0	-0.5	-0.6	-0.8	-0.8	-0.4	-1.0
Waist Hip Ratio (WHR)	0.4	1.9	8.0	0.3	0.8	0.2	2.1	0.7	-2.8
Average weekly spirits intake	0.4	0.5	1.8	0.5	0.6	0.8	0.2	0.5	-1.3
Hearing difficulty/problems: Yes	0.4	0.6	2.2	0.2	0.5	0.2	1.2	0.7	-1.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.3	-0.8	-0.5	-0.2	0.6	-0.4	-1.1
Diabetes (mother)	0.4	0.5	1.2	0.5	0.6	-0.2	1.1	0.7	-1.1
Serious illness, injury or assault to yourself	0.4	0.4	0.8	-0.6	-0.9	-0.6	-0.6	-0.8	-0.7
Supplements: Glucosamine	0.4	0.5	1.3	0.7	0.5	0.9	-0.6	0.5	1.1
Alcohol usually taken with meals	0.4	0.7	1.9	-0.7	-0.5	-1.1	-0.7	-0.5	1.4
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.6	0.1	0.3	-1.2	-1.0	0.2	-1.3
Pulse wave reflection index	0.4	0.5	1.9	-0.3	-0.6	-1.4	-0.9	-0.6	0.2
High blood pressure (siblings)	0.4	0.6	1.6	0.7	0.6	1.3	0.5	0.6	-1.1
Shortness of breath walking on level ground	0.4	0.5	2.4	-0.4	-0.4	-0.3	0.6	-0.5	-1.6
Migraine (self-reported)	0.4	0.5	2.2	0.1	-0.0	-0.4	-1.5	-0.0	1.2
Medication: Allopurinol	0.4	0.5	1.0	0.4	0.8	0.6	0.6	1.0	1.0
Suffer from ‘nerves’	0.4	0.6	1.6	1.0	0.8	1.3	-0.2	0.8	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.1	-0.7	-0.8	-1.1	-0.7	-0.6	-0.5
Mineral and other dietary supplements	0.4	0.5	1.3	-0.8	-0.7	0.3	-0.6	-0.7	-1.1
Miserableness	0.4	0.7	1.6	1.2	1.3	-0.3	0.4	1.2	0.7
Commuting to job workplace: Public transport	0.4	0.5	1.3	-0.7	-0.9	-0.6	-1.1	-0.9	-0.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.5	-0.4	-0.3	-0.8	0.1	-0.2	-1.6
Ever smoked	0.4	0.7	1.8	-0.5	-0.6	-1.4	-0.8	-0.6	-1.2
Age started oral contraceptive pill	0.4	0.5	1.8	-0.1	-0.3	1.2	0.4	-0.3	1.3
Commuting to job workplace: Cycle	0.4	0.5	1.1	0.7	0.8	-0.5	1.1	0.7	0.5
Cholesterol lowering medication	0.4	0.6	3.0	-0.3	-0.6	-0.4	-1.7	-0.5	0.4
Worry (Nagel 2018)	0.3	0.7	2.0	1.0	0.7	0.9	-0.4	0.7	1.4
Lung FVC	0.3	1.4	5.7	0.7	0.8	0.2	1.5	0.8	2.4
Chronotype (morning person)	0.3	0.6	1.6	-0.6	-0.9	-1.3	0.2	-0.8	0.7
Medication: Metformin	0.3	0.5	2.0	-0.7	-0.6	0.0	0.1	-0.5	-1.4
Trunk fat percentage	0.3	1.0	3.9	0.8	1.0	-0.7	2.0	1.0	0.0
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	0.2	0.3	0.9	0.7	0.4	0.9
Had menopause	0.3	0.4	0.9	-0.6	-1.0	0.2	-0.8	-0.8	-0.6
Falls in the last year	0.3	0.5	1.3	0.4	0.6	-1.1	1.1	0.6	0.1
Exposure to tobacco smoke at home	0.3	0.3	1.9	-0.1	-0.2	-0.1	-1.4	-0.1	0.1
Hair/balding pattern: Pattern 4	0.3	0.7	3.4	-0.6	-0.2	-0.3	1.1	-0.3	-1.8
Birth weight	0.3	0.8	1.7	0.8	0.8	1.3	0.9	0.8	1.0
Leg fat percentage (right)	0.3	1.1	5.7	-0.4	-0.3	-0.2	1.3	-0.2	-2.4
Comparative body size at age 10	0.3	0.9	5.3	-0.3	0.1	0.6	0.8	0.1	-2.3
Pulse wave peak to peak time	0.3	0.3	1.6	-0.2	-0.2	1.2	-0.1	-0.2	0.6
Supplements: Vitamin C	0.3	0.3	1.5	0.2	-0.1	-1.2	-0.8	-0.2	0.1
Illnesses of father: Heart disease	0.3	0.4	1.7	0.4	0.6	-0.7	-0.1	0.6	1.3
Ever had bowel cancer screening	0.3	0.4	0.7	-0.5	-0.8	-0.9	-0.4	-0.8	-0.2
Osteoarthritis (self-reported)	0.3	0.4	2.2	-0.0	-0.0	0.2	-1.5	-0.1	-0.7
Illnesses of father: None of the above (group 1)	0.3	0.3	1.5	0.7	0.3	0.3	-0.2	0.3	1.2
Schizophrenia vs Biploar Disorder	0.2	0.2	0.6	0.8	0.4	-0.0	0.4	0.5	-0.6
Irritable Bowel Disease (IBD)	0.2	0.5	1.1	0.7	0.7	-0.1	1.1	0.7	0.9
Breast Cancer	0.2	0.4	1.8	0.2	-0.3	-1.4	-0.2	-0.1	-0.8
Crohns Disease (2012)	0.2	0.3	1.1	-0.4	-0.5	-1.1	0.3	-0.6	0.0
LDL Cholesterol	0.2	0.3	1.1	-0.2	-0.1	-0.8	-0.2	-0.1	1.1
Blood Red Count	0.2	1.5	2.9	-0.7	-1.5	-0.1	-1.6	-1.4	1.7
Impedance of leg (right)	0.2	1.2	3.0	1.7	1.4	0.8	1.0	1.3	0.2
Age when periods started (menarche)	0.2	0.4	2.1	0.5	0.6	0.4	0.2	0.5	1.4
Stomach or abdominal pain in last month	0.2	0.3	0.9	1.0	0.3	0.0	-0.7	0.2	-0.7
Sitting height	0.2	1.2	7.0	0.2	0.1	0.5	-1.2	0.1	2.6
Body mass index (BMI)	0.2	0.9	3.0	-1.1	-0.8	-0.6	0.4	-0.8	-1.7
Impedance of leg (left)	0.2	0.7	1.8	1.4	1.0	-0.0	1.1	0.9	-0.5
Past tobacco smoking	0.2	0.5	0.9	0.5	0.6	0.9	1.0	0.5	0.8
Allergy	0.2	0.4	0.9	0.8	0.9	0.2	0.7	0.9	-0.0
Pain all over the body in last month	0.2	0.2	0.7	0.2	-0.0	-0.9	-0.4	-0.0	0.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.9	0.0	-0.1	-0.5	-0.8	-0.0	0.9
Trunk fat-free mass	0.2	0.9	3.4	-0.1	0.0	1.9	-0.8	0.1	1.4
Number of live births	0.2	0.3	0.6	-0.1	-0.8	0.2	0.5	-0.7	-0.7
Pulse wave Arterial Stiffness index	0.2	0.2	1.1	0.3	0.3	-1.0	0.1	0.3	-0.2
Trunk predicted mass	0.2	0.9	3.6	-0.0	0.1	1.9	-0.8	0.2	1.5
Peak expiratory flow (PEF)	0.2	0.4	1.1	-0.5	-0.5	-1.0	0.6	-0.7	0.6
Blood clot in the leg (DVT)	0.2	0.3	0.5	0.7	0.6	0.5	-0.4	0.5	-0.6
Medication: Paracetamol	0.2	0.3	0.8	-0.6	-0.7	0.1	-0.9	-0.8	-0.1
Gout (self-reported)	0.2	0.3	1.0	0.2	0.7	-0.3	-0.5	0.7	1.0
Body fat percentage	0.2	0.8	3.3	0.4	0.6	-0.6	1.8	0.7	-0.9
Exposure to tobacco smoke outside home	0.2	0.3	0.8	-0.5	-0.4	-0.9	-0.1	-0.4	-0.9
Number of full brothers	0.2	0.3	1.4	-0.2	-0.2	0.1	1.2	-0.2	-0.8
Medication for pain relief, constipation, heartburn	0.2	0.3	0.6	0.7	0.6	-0.4	0.8	0.6	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.9	-0.2	-0.2	0.4	0.9	-0.2	-0.4
Illnesses of siblings: Diabetes	0.2	0.2	0.8	-0.1	-0.0	0.0	0.9	-0.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.9	1.0	0.8	0.3	-0.7	0.7	0.8
Loneliness, isolation	0.2	0.2	0.4	0.4	0.6	-0.4	0.6	0.6	0.6
Eye problems/disorders: Cataract	0.2	0.3	1.7	0.1	0.1	-0.1	0.5	0.1	-1.3
Osteoporosis (self-reported)	0.2	0.2	0.5	-0.0	-0.4	-0.3	0.7	-0.4	-0.7
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	0.7	0.4	0.5	-0.7	0.5	0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.7	0.3	0.2	-0.5	0.7	0.2	0.8
High cholesterol (Self-reported)	0.2	0.4	1.6	-0.4	-0.6	0.0	-1.3	-0.4	-0.7
Diastolic blood pressure, automated reading	0.2	0.8	1.7	-1.3	-1.3	-0.2	-0.7	-1.2	-0.1
Myopia	0.2	0.3	1.8	0.1	-0.0	1.4	-0.6	0.0	-0.4
Basal cell carcinoma (self-reported)	0.2	0.2	0.7	0.3	0.1	0.5	-0.9	0.1	0.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.9	0.2	0.1	0.4	-0.6	-0.0	-0.9
Heart disease (siblings)	0.2	0.3	0.8	-0.4	-0.5	0.9	0.5	-0.5	-0.3
Leg fat mass (left)	0.2	0.6	2.9	-0.7	-0.5	-0.4	0.8	-0.4	-1.7
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.9	0.8	0.7	0.7	0.3	0.7	0.9
Alzheimer’s Disease (in mother)	0.1	0.2	0.4	-0.4	-0.3	-0.5	0.0	-0.3	-0.6
Alzheimer’s Disease (including proxy)	0.1	0.1	0.4	0.2	0.2	0.4	0.2	0.1	-0.6
Crohns Disease (2017)	0.1	0.3	0.8	-0.4	-0.3	0.9	0.8	-0.3	0.5
Bipolar Disorder (2011)	0.1	0.1	0.5	0.1	0.3	0.7	-0.1	0.3	0.0
HDL Cholesterol	0.1	0.1	0.3	-0.2	-0.3	-0.3	0.5	-0.3	0.0
Lupus	0.1	0.2	0.5	-0.3	-0.6	0.1	-0.0	-0.7	-0.7
BMI	0.1	0.8	3.0	-0.8	-0.7	-0.1	1.1	-0.7	-1.7
Allergy or Eczema	0.1	0.3	1.7	-0.2	-0.3	-0.1	0.4	-0.3	1.3
Hair Pigment	0.1	1.6	3.7	-1.9	-1.5	-0.6	-1.2	-1.5	-0.9
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.3	-0.4	-0.2	0.0	-0.5	-0.3
Leg fat-free mass (left)	0.1	0.7	2.9	0.2	0.4	1.2	-0.3	0.4	1.7
Qualifications: CSEs or equivalent	0.1	0.2	0.8	0.3	0.4	-0.2	0.0	0.4	-0.9
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.8	-0.2	-0.4	0.3	0.5	-0.4	0.9
Leg predicted mass (left)	0.1	0.7	2.8	0.2	0.4	1.2	-0.3	0.4	1.7
Trunk fat mass	0.1	0.4	1.8	0.5	0.7	-0.3	1.3	0.7	0.2
Waist circumference	0.1	0.2	1.1	-0.5	-0.2	-0.3	0.4	-0.2	-1.1
Arm fat percentage (right)	0.1	0.5	2.1	0.3	0.6	-0.7	1.5	0.6	-0.6
Hip circumference	0.1	0.4	1.5	0.5	0.5	0.6	-0.0	0.6	1.2
Pulse rate	0.1	0.1	0.5	-0.2	-0.2	0.3	-0.0	-0.2	-0.7
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.0	0.4	0.4	1.0	-0.1	0.3	0.8
Lung cancer (father)	0.1	0.1	0.1	0.3	0.3	0.3	0.3	0.3	0.0
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	1.0	-0.0	-0.1	-0.0	-1.0	0.0	0.1
Arm fat-free mass (right)	0.1	0.3	1.0	-0.4	-0.3	1.0	-0.5	-0.3	0.7
Eye problems/disorders: None of the above	0.1	0.1	0.8	0.0	-0.2	-0.4	-0.3	-0.2	0.9
Leg fat mass (right)	0.1	0.4	2.0	-0.6	-0.3	-0.1	0.7	-0.2	-1.4
Arm predicted mass (right)	0.1	0.4	1.5	-0.5	-0.3	1.2	-0.4	-0.3	0.8
Number of full sisters	0.1	0.1	0.4	-0.1	-0.3	0.6	-0.2	-0.3	0.2
Had major operations	0.1	0.1	0.7	-0.1	-0.3	-0.2	0.0	-0.2	0.8
Smoking status: Previous	0.1	0.2	0.5	0.5	0.6	0.1	0.1	0.7	0.2
Whole body fat-free mass	0.1	0.7	2.2	-0.1	0.0	1.4	-0.7	0.0	1.5
Leg fat-free mass (right)	0.1	0.5	2.4	0.1	0.3	0.8	-0.3	0.3	1.6
Arm fat percentage (left)	0.1	0.6	2.5	0.0	0.3	-0.7	1.6	0.4	-0.9
Mood swings	0.1	0.1	0.7	-0.0	0.3	0.3	-0.2	0.3	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.7	-0.1	-0.2	0.5	-0.8	-0.2	-0.2
Breast cancer (self-reported)	0.1	0.1	0.2	-0.1	-0.1	-0.4	0.5	-0.1	-0.4
Whole body water mass	0.1	0.7	2.7	-0.1	0.1	1.3	-0.7	0.1	1.6
Leg predicted mass (right)	0.1	0.4	2.1	0.0	0.2	0.7	-0.3	0.2	1.4
Mother’s age at death	0.1	0.2	0.4	0.6	0.3	0.7	-0.3	0.3	0.3
Alcohol drinker status: Never	0.1	0.2	0.4	0.4	0.5	0.6	-0.0	0.6	-0.2
Basal metabolic rate	0.1	0.5	1.6	-0.0	0.1	1.2	-0.4	0.1	1.2
Arm fat-free mass (left)	0.1	0.4	1.2	-0.4	-0.2	1.1	-0.4	-0.2	0.9
Average weekly beer plus cider intake	0.1	0.1	0.3	0.1	0.2	0.5	0.0	0.3	-0.5
Alcohol drinker status: Previous	0.1	0.1	0.4	-0.4	-0.4	-0.6	-0.0	-0.4	0.0
Arm predicted mass (left)	0.1	0.4	1.8	0.0	0.1	1.3	-0.3	0.1	1.1
HbA1C	0.0	0.0	0.1	0.2	0.0	-0.3	0.1	-0.0	-0.1
Tanning	0.0	0.1	0.5	0.0	-0.1	0.7	-0.5	0.0	0.1
Weight	0.0	0.1	0.3	-0.1	0.0	0.5	0.1	0.1	0.5
Arm fat mass (right)	0.0	0.2	0.8	-0.2	0.1	-0.4	0.9	0.2	-0.3
Whole body fat mass	0.0	0.2	1.0	0.1	0.3	-0.1	1.0	0.4	-0.4
Arm fat mass (left)	0.0	0.1	0.5	-0.3	-0.0	-0.4	0.7	0.0	-0.4

Hub : Genes

ATAD1

Models

Trait associations