Best TWAS P=2.44e-09 · Best GWAS P=2.24e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | NUCB2 | 0.36 | 0.23 | lasso | 6 | 0.24 | 2.6e-08 | -6.0 | -5.2 | 1.6e-07 | 0.95 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | NUCB2 | 0.13 | 0.11 | lasso | 2 | 0.09 | 1.7e-07 | -5.9 | -5.8 | 8.7e-09 | 0.99 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Colon Transverse | NUCB2 | 0.13 | 0.09 | lasso | 6 | 0.06 | 9.6e-04 | -4.7 | -5.5 | 2.9e-08 | 0.96 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Esophagus Mucosa | NUCB2 | 0.08 | 0.03 | lasso | 4 | 0.04 | 8.8e-04 | 4.7 | -5.4 | 7.1e-08 | 0.92 | 0.02 | 0.97 | FALSE |
| 5 | GTEx | Spleen | NUCB2 | 0.20 | 0.21 | lasso | 2 | 0.17 | 4.2e-05 | -6.0 | -6.0 | 2.4e-09 | 1.00 | 0.01 | 0.98 | TRUE |
| 6 | GTEx | Testis | NUCB2 | 0.28 | 0.13 | lasso | 9 | 0.10 | 2.5e-05 | -5.9 | 5.6 | 2.3e-08 | -0.97 | 0.00 | 0.99 | FALSE |
| 7 | GTEx | Thyroid | NUCB2 | 0.07 | 0.02 | lasso | 4 | 0.02 | 1.3e-02 | -5.9 | -5.7 | 1.1e-08 | 0.88 | 0.02 | 0.92 | FALSE |
| 8 | METSIM | Adipose | NUCB2 | 0.05 | 0.07 | enet | 10 | 0.05 | 4.0e-08 | -5.9 | -5.5 | 3.9e-08 | 0.96 | 0.01 | 0.99 | FALSE |
| 9 | YFS | Blood | NUCB2 | 0.12 | 0.13 | lasso | 4 | 0.14 | 2.7e-44 | -5.9 | -6.0 | 2.6e-09 | 0.95 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NUCB2 | 0.07 | 0.00 | blup | 66 | 0.02 | 8.5e-04 | -3.8 | 5.2 | 2.2e-07 | -0.52 | 0.01 | 0.70 | FALSE |