TWAS hub - NUCB2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cortex	0.2120	0.0720	1.3e-03	0.117	NA	0.089	NA	0.099	4.0e-04	NA	2.0e-03	NA	1.1e-03
2	GTEx	Cells EBV-transformed lymphocytes	0.3640	0.0880	1.5e-05	0.227	NA	0.202	NA	0.238	5.8e-08	NA	3.6e-07	NA	2.6e-08
3	GTEx	Cells Transformed fibroblasts	0.1330	0.0420	4.1e-05	0.114	NA	0.090	NA	0.093	6.7e-09	NA	2.9e-07	NA	1.7e-07
4	GTEx	Colon Transverse	0.1270	0.0450	5.6e-04	0.093	NA	0.040	NA	0.058	3.4e-05	NA	5.2e-03	NA	9.5e-04
5	GTEx	Esophagus Mucosa	0.0760	0.0320	4.4e-03	0.028	NA	0.040	NA	0.042	5.7e-03	NA	1.1e-03	NA	8.8e-04
6	GTEx	Ovary	0.3140	0.0970	1.2e-03	-0.011	NA	0.008	NA	-0.007	8.1e-01	NA	2.0e-01	NA	5.0e-01
7	GTEx	Spleen	0.2020	0.0730	3.1e-03	0.209	NA	0.153	NA	0.168	4.4e-06	NA	1.0e-04	NA	4.2e-05
8	GTEx	Testis	0.2840	0.0730	8.1e-05	0.131	NA	0.072	NA	0.103	2.0e-06	NA	4.1e-04	NA	2.5e-05
9	GTEx	Thyroid	0.0740	0.0330	9.5e-03	0.022	NA	0.017	NA	0.018	7.3e-03	NA	1.8e-02	NA	1.3e-02
10	METSIM	Adipose	0.0546	0.0169	8.3e-07	0.067	0.040	0.051	0.038	0.035	2.6e-10	1.0e-06	4.0e-08	1.7e-06	5.2e-06
11	NTR	Blood	0.0410	0.0137	1.4e-04	0.002	0.016	0.003	0.016	0.000	6.9e-02	5.6e-06	3.2e-02	4.9e-06	4.3e-01
12	ROSMAP	Brain Pre-frontal Cortex	0.2342	0.0349	0.0e+00	0.316	0.251	0.311	0.308	0.312	2.0e-41	5.1e-32	1.1e-40	2.7e-40	8.1e-41
13	YFS	Blood	0.1153	0.0226	0.0e+00	0.134	0.112	0.137	0.140	0.143	1.3e-41	1.2e-34	1.4e-42	1.6e-43	2.7e-44
14	TCGA	Breast Invasive Carcinoma	0.1781	0.0534	3.9e-09	0.046	0.051	0.052	NA	0.044	8.4e-10	1.2e-10	7.9e-11	NA	1.8e-09
15	TCGA	Esophageal Carcinoma	0.2990	0.1070	5.2e-03	-0.008	0.042	0.038	NA	0.004	6.8e-01	1.8e-02	2.4e-02	NA	2.4e-01
16	TCGA	Kidney Renal Clear Cell Carcinoma	0.1010	0.0418	2.4e-05	0.043	0.043	0.050	NA	0.042	1.3e-05	1.2e-05	2.6e-06	NA	1.5e-05
17	TCGA	Brain Lower Grade Glioma	0.0711	0.0401	1.1e-03	0.004	0.024	0.023	NA	0.009	1.1e-01	8.5e-04	1.0e-03	NA	3.1e-02
18	TCGA	Prostate Adenocarcinoma	0.1737	0.0669	4.7e-08	0.059	0.064	0.053	NA	0.057	8.2e-07	2.8e-07	2.7e-06	NA	1.4e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Systolic Blood Pressure	8.7	43.7	84.5	7.2	-7.2	-7.3	-7.4	-7.0	-5.7	-7.2	7.0	-7.3	-7.2	-4.6	7.2	-5.3	-2.4	-4.4	-9.2	2.2	8.4
Medication: Gliclazide	7.9	9.0	15.3	3.9	-3.2	-3.3	-3.5	-3.3	-1.6	-3.4	3.4	-3.1	-3.4	-2.5	3.4	-3.2	-1.6	-0.8	-3.6	2.6	2.3
Mouth/teeth dental problems: Dentures	7.8	13.1	21.4	-4.6	4.3	4.4	4.5	4.3	3.6	4.2	-3.9	2.8	4.5	2.0	-4.1	3.5	-1.3	0.9	3.9	-1.3	-3.6
Financial situation satisfaction	6.7	8.3	13.8	-3.5	3.7	3.5	3.4	3.2	2.4	3.5	-3.3	2.8	3.5	0.5	-3.3	2.9	0.1	0.7	3.0	-1.6	-2.7
Ulcerative Colitis	6.1	8.9	20.6	-4.4	3.6	3.2	3.3	3.0	1.8	3.4	-3.6	3.3	3.1	0.8	-4.5	2.7	0.6	-1.3	2.2	-3.5	-1.1
High blood pressure (mother)	6.1	8.6	19.4	3.0	-3.8	-3.3	-3.2	-2.9	-0.8	-3.6	3.1	-4.4	-3.1	-1.5	3.2	-2.9	-1.0	-2.1	-3.8	1.6	2.6
Medication: Omeprazole (e.g. Zanprol)	5.9	7.2	13.8	2.9	-3.1	-3.5	-3.5	-3.7	-2.9	-3.3	3.2	-2.4	-3.5	-1.5	1.8	-3.4	0.8	0.9	-1.8	1.5	0.3
Medication: Omeprazole	5.8	7.0	13.5	2.7	-3.1	-3.5	-3.5	-3.7	-2.9	-3.3	3.1	-2.3	-3.6	-1.2	1.5	-3.5	1.4	0.4	-2.1	1.0	0.3
Hair/balding pattern: Pattern 2	5.7	7.3	16.3	1.2	-4.0	-3.3	-3.2	-2.8	-4.0	-3.5	2.7	-3.3	-3.1	-0.9	0.8	-2.8	-2.0	-1.7	-3.3	0.5	1.1
Diabetes (self-reported)	5.3	8.1	15.8	4.0	-2.6	-2.9	-3.3	-3.1	-1.7	-2.9	2.9	-3.5	-3.2	-2.5	3.3	-2.7	-1.1	-1.2	-3.9	1.4	3.1
Schizophrenia (2014)	5.2	11.6	18.4	-3.5	3.9	4.0	4.3	4.0	2.9	4.0	-3.6	4.3	4.2	-0.0	-3.6	3.4	-0.5	0.3	4.1	-1.3	-3.7
Medication: Paracetamol	5.2	8.0	15.6	-1.9	3.4	3.6	3.7	3.4	3.2	3.4	-3.0	2.9	3.8	0.2	-1.8	3.1	-0.6	1.4	4.0	-0.6	-2.4
High blood pressure	4.9	13.6	29.7	3.5	-3.5	-4.1	-4.0	-3.6	-2.2	-4.2	3.8	-5.2	-4.0	-2.8	3.4	-3.7	-2.6	-3.3	-5.5	2.4	3.0
Cardiovascular Disease	4.8	15.8	38.3	3.8	-4.4	-4.6	-4.5	-4.1	-2.1	-4.8	4.5	-6.2	-4.5	-2.6	3.9	-3.8	-1.6	-2.9	-4.9	1.9	3.2
Systolic blood pressure, automated reading	4.8	13.9	26.5	3.7	-3.9	-4.4	-4.4	-4.3	-4.0	-4.2	3.9	-4.2	-4.4	-2.5	3.4	-3.5	-1.0	-1.7	-5.2	1.2	4.0
Type 2 Diabetes (T2D) (2018)	4.7	8.9	15.9	4.0	-2.9	-2.9	-3.4	-3.2	-2.0	-2.9	2.8	-3.9	-3.4	-2.0	3.5	-3.0	-1.3	-1.1	-4.0	1.4	3.5
Comparative height size at age 10	4.7	25.6	44.9	5.2	-5.4	-6.2	-6.3	-6.4	-5.3	-5.9	5.4	-5.0	-6.2	-1.9	4.5	-5.0	-1.2	-2.7	-6.7	1.5	5.3
Hypertension (Self-reported)	4.7	13.2	27.9	3.5	-3.7	-4.0	-3.9	-3.6	-2.3	-4.2	3.8	-4.9	-3.9	-3.0	3.5	-3.6	-2.2	-3.0	-5.3	2.3	2.9
Diabetes diagnosed by doctor	4.7	7.7	16.8	4.1	-2.7	-2.8	-3.3	-3.1	-1.6	-2.8	2.7	-3.4	-3.2	-1.8	3.3	-2.9	-0.9	-0.8	-3.5	1.4	3.0
Age when periods started (menarche)	4.6	11.1	42.4	-2.7	4.0	4.1	4.0	3.7	0.3	4.0	-3.8	6.5	4.0	1.0	-2.5	4.3	-0.2	-1.0	2.8	-2.6	-0.2
Cholesterol lowering medication	4.6	6.8	16.8	2.2	-3.1	-3.3	-3.1	-2.9	-0.9	-3.5	3.1	-4.1	-3.1	-0.8	2.0	-3.2	-1.1	-1.6	-3.0	1.5	0.7
Medication: Bendroflumethiazide	4.5	6.8	14.3	3.0	-2.1	-3.0	-2.8	-2.8	-1.6	-2.8	2.8	-3.0	-2.8	-2.8	2.9	-2.4	-0.8	-1.9	-3.8	1.8	2.6
Smoking status: Current	4.3	6.8	12.8	-2.4	3.4	3.2	3.4	3.3	2.9	3.0	-2.8	1.2	3.4	0.6	-2.3	1.9	-0.4	1.7	3.0	0.4	-3.6
Smoking Status	4.2	10.0	23.6	-3.2	4.2	3.6	4.0	3.8	4.3	3.4	-3.0	1.5	3.7	1.9	-3.0	1.8	-1.2	1.3	3.3	0.9	-4.9
Qualifications: O levels/GCSEs or equivalent	4.2	6.6	10.1	2.6	-3.2	-3.0	-3.1	-2.9	-2.4	-3.1	3.1	-2.5	-3.1	-1.6	2.7	-2.8	0.6	-1.6	-2.8	0.7	2.5
Height	4.0	76.4	125.4	8.9	-9.5	-10.7	-11.2	-11.1	-10.4	-10.2	9.4	-6.7	-11.0	-6.7	7.3	-8.9	-0.9	-3.5	-11.2	3.3	7.0
Current tobacco smoking	4.0	6.6	14.1	-2.5	3.3	3.1	3.3	3.3	2.8	2.8	-2.7	1.1	3.3	0.3	-2.4	1.7	-0.8	1.4	2.8	0.5	-3.8
Mouth/teeth dental problems	4.0	6.1	12.0	2.7	-2.5	-3.1	-3.1	-3.1	-2.2	-2.9	2.6	-1.8	-3.2	-0.9	2.0	-2.3	1.8	-0.9	-2.9	-0.3	3.5
Illnesses of father: High blood pressure	3.9	4.8	9.4	2.1	-2.6	-2.4	-2.4	-2.2	-1.5	-2.7	2.8	-3.1	-2.3	-2.3	2.7	-2.2	-0.9	-0.6	-2.0	1.8	1.0
Medication: Metformin	3.8	5.3	10.5	3.2	-2.7	-2.5	-2.6	-2.4	-0.9	-2.5	2.4	-2.5	-2.6	-1.8	2.8	-2.0	-0.6	-0.4	-2.8	0.9	2.9
Irritable Bowel Disease (IBD)	3.7	8.8	21.5	-4.6	3.2	3.3	3.2	3.0	1.9	3.3	-3.4	2.0	3.2	1.8	-4.6	2.7	0.7	0.0	3.0	-3.3	-2.2
Qualifications: None of the above	3.7	8.0	15.0	-3.5	3.8	3.1	3.2	2.9	2.0	3.3	-3.4	1.9	3.2	3.1	-3.9	3.0	-0.2	0.7	2.4	-2.1	-1.9
Average weekly red wine intake	3.7	5.5	9.8	3.1	-2.7	-2.9	-2.6	-2.5	-2.0	-2.8	2.8	-2.4	-2.7	-1.0	3.1	-2.6	-0.4	0.7	-2.1	2.1	1.2
Bipolar Disorder or Schizophrenia	3.3	8.0	13.7	-3.4	3.2	3.2	3.5	3.0	2.5	3.2	-3.1	3.7	3.4	-0.4	-3.4	2.8	-0.9	-0.7	3.2	-1.4	-2.5
Exposure to tobacco smoke at home	3.3	3.7	6.2	-2.5	2.2	2.4	2.4	2.2	1.6	2.4	-2.5	1.1	2.5	1.0	-2.5	2.4	-0.8	-0.8	1.3	-1.0	-0.7
Back pain experienced in last month	3.2	4.7	9.0	-3.0	1.9	2.4	2.7	2.5	1.7	2.3	-2.8	2.2	2.5	-0.2	-2.8	2.3	0.3	0.2	2.7	-1.6	-1.4
Body Mass Index (BMI) (2010)	3.1	4.3	13.2	-1.5	2.1	2.2	2.5	2.5	3.0	1.9	-1.6	1.0	2.4	0.8	-0.9	1.4	0.3	2.1	3.6	0.4	-3.0
Fluid intelligence score	3.1	6.5	27.6	3.3	-2.3	-2.1	-2.7	-2.5	-1.9	-2.1	2.3	-2.2	-2.4	0.7	3.3	-1.2	-0.4	-3.0	-3.0	0.0	5.3
Medication: Paracetamol	3.1	5.2	11.7	-1.8	2.8	2.7	2.9	2.7	2.0	2.5	-2.5	2.4	3.0	0.6	-1.7	2.4	-0.8	1.2	3.4	-0.6	-2.0
Prospective memory result	3.0	3.7	7.2	-2.3	2.3	2.1	1.9	1.6	0.5	2.1	-2.2	2.7	1.9	2.0	-2.4	1.9	1.7	0.6	2.0	-1.9	-1.1
Vascular/heart problems diagnosed by doctor	3.0	8.2	20.1	-2.4	2.6	3.2	3.0	2.8	1.4	3.3	-2.9	4.5	3.1	2.5	-2.4	2.9	2.0	2.6	4.3	-1.7	-2.0
Schizophrenia (2018)	2.9	6.1	11.6	-2.5	3.0	2.8	3.2	2.8	2.5	2.8	-2.5	3.4	3.0	-0.4	-2.7	2.3	-1.2	-0.4	2.6	-0.6	-2.7
Crohns Disease (2017)	2.9	6.4	11.5	-3.2	2.7	3.0	2.6	2.5	0.9	3.0	-3.1	0.8	2.9	3.3	-3.4	2.7	0.3	-0.1	2.9	-2.4	-1.8
Blood Eosinophil Count	2.9	22.6	35.6	4.5	-5.2	-5.8	-5.5	-5.4	-2.6	-6.0	5.6	-5.7	-5.5	-3.6	5.1	-6.0	-1.7	-0.4	-4.9	5.2	1.1
Impedance of leg (right)	2.9	14.1	23.8	4.5	-4.1	-3.9	-4.3	-4.0	-3.7	-3.8	4.0	-1.3	-4.1	-4.1	4.2	-3.2	-0.8	-3.0	-4.9	1.4	4.9
Medication: Blood pressure	2.9	5.1	13.7	1.8	-1.7	-2.5	-2.5	-2.3	-0.8	-2.4	2.1	-3.3	-2.5	-2.2	1.6	-2.0	-1.8	-2.6	-3.7	0.8	1.8
Medication: Ramipril	2.8	3.6	6.4	1.3	-1.9	-2.5	-2.4	-2.5	-1.6	-2.3	1.7	-2.5	-2.5	-0.8	0.9	-1.7	0.5	-1.3	-2.4	-0.5	2.5
Ever smoked	2.8	5.0	10.6	-3.0	2.8	2.3	2.5	2.2	1.9	2.4	-2.2	0.9	2.3	2.5	-2.8	1.5	-0.1	1.3	2.5	-0.7	-3.3
Noisy workplace	2.7	3.3	9.8	-2.3	2.1	2.0	2.0	1.7	2.6	2.0	-1.9	0.6	2.0	-0.4	-1.8	0.8	-1.5	-0.3	1.7	0.4	-3.1
Standing height	2.7	27.3	47.6	5.2	-5.5	-6.4	-6.7	-6.5	-6.4	-6.2	5.6	-3.5	-6.5	-3.2	4.1	-4.9	-1.1	-3.3	-6.9	1.1	5.3
Medication: Blood pressure	2.7	5.2	11.5	1.9	-2.3	-2.7	-2.6	-2.4	-2.2	-2.8	2.2	-2.9	-2.5	-0.9	2.0	-1.9	-0.9	-1.7	-3.4	0.3	2.8
Ovarian Cancer	2.6	3.4	6.5	2.6	-1.9	-2.0	-2.2	-2.1	-1.1	-1.9	1.6	-2.4	-2.2	-1.8	2.2	-2.0	-0.0	0.9	-1.8	1.8	1.4
Blood Platelet Count	2.6	30.2	52.4	-5.2	6.0	6.6	7.2	7.2	5.9	6.1	-5.9	4.4	7.0	4.0	-4.6	6.0	2.4	2.3	6.9	-3.1	-3.8
Vitamin and mineral supplements	2.6	3.5	6.8	1.9	-1.9	-2.2	-2.1	-1.8	-1.5	-2.2	1.8	-2.6	-2.1	-1.9	1.6	-1.8	-0.2	-1.9	-2.6	0.5	1.6
Medication: Co-codamol	2.6	3.0	7.5	-1.9	2.7	1.9	2.1	2.1	1.5	1.9	-1.5	1.3	2.0	0.9	-1.8	1.3	0.2	1.3	2.0	-0.2	-2.2
Birth weight	2.6	5.6	15.8	-2.6	2.9	2.6	2.4	2.2	0.9	2.7	-2.4	4.0	2.6	2.2	-2.5	2.6	0.7	-1.1	2.9	-1.9	-0.8
Ulcerative Colitis (UC)	2.5	4.8	13.8	-3.7	2.4	2.2	2.4	2.2	2.0	2.2	-2.1	2.2	2.2	0.3	-3.5	1.6	0.9	0.2	1.9	-2.6	-1.3
Hypothyroidism (self reported)	2.5	5.8	12.6	1.8	-2.3	-3.1	-3.4	-3.5	-2.5	-2.7	2.2	-3.3	-3.3	-1.7	1.0	-2.8	0.4	-1.4	-2.6	0.1	1.3
Past tobacco smoking	2.5	4.6	9.1	3.0	-2.6	-2.1	-2.3	-2.1	-2.2	-2.2	2.0	-0.7	-2.0	-2.9	2.9	-1.2	0.3	-0.9	-2.2	1.0	3.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.5	2.9	7.2	-0.7	2.5	1.9	1.9	1.9	2.0	1.9	-1.2	1.1	1.9	0.8	-0.6	1.3	0.2	2.4	2.1	1.0	-2.7
Unable to work because of sickness or disability	2.5	3.2	6.6	-1.2	2.6	2.2	2.4	2.0	1.4	2.4	-2.0	0.2	2.1	0.9	-1.5	1.7	1.0	1.2	2.4	-0.5	-2.0
Type 2 Diabetes (T2D) (2012)	2.4	2.8	7.0	2.3	-1.8	-1.5	-1.8	-2.0	-0.1	-1.6	1.4	-0.7	-1.9	-2.4	1.9	-1.2	1.3	0.1	-1.7	-0.5	2.6
Impedance of arm (right)	2.4	11.3	28.0	4.5	-3.7	-3.4	-3.8	-3.4	-4.0	-3.4	3.4	-0.7	-3.6	-2.8	3.9	-2.2	0.0	-2.1	-4.4	0.3	5.3
Pulse wave reflection index	2.4	3.0	6.3	-2.1	1.1	2.0	1.8	1.7	2.5	2.2	-2.4	1.7	1.8	1.5	-1.8	2.1	0.8	0.3	1.3	-1.8	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.4	2.9	5.4	1.9	-1.8	-2.3	-2.2	-2.1	-1.1	-2.3	2.3	-1.1	-2.2	-0.1	1.9	-2.2	0.2	-0.5	-1.6	1.0	1.0
Happiness	2.3	2.8	5.2	-1.6	2.1	2.0	2.1	1.9	1.9	2.1	-1.7	1.4	1.9	0.4	-1.6	1.2	0.6	0.8	1.9	-0.5	-2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.5	9.5	-0.8	2.1	2.3	2.5	2.4	3.1	2.2	-1.6	2.6	2.3	0.3	-0.1	1.9	-0.3	1.3	1.9	0.9	-1.4
Medication for cholesterol, blood pressure or diabetes	2.3	3.8	10.7	-1.7	1.8	2.2	2.2	2.1	0.9	2.1	-1.9	3.3	2.3	1.8	-1.6	1.8	1.1	1.4	2.8	-1.1	-1.2
Alcohol drinker status: Never	2.3	2.7	6.7	1.4	-1.7	-2.1	-2.0	-2.2	-1.1	-2.0	1.9	-2.6	-2.1	0.2	1.1	-2.0	0.8	1.4	-1.2	0.8	-0.0
Impedance of whole body	2.3	11.8	27.7	4.6	-3.8	-3.4	-3.9	-3.4	-4.2	-3.4	3.5	-0.5	-3.7	-2.9	4.2	-2.4	0.1	-2.3	-4.3	0.5	5.3
Maternal smoking around birth	2.2	3.1	8.4	-2.8	2.1	1.6	1.6	1.7	2.9	1.7	-2.0	0.3	1.7	-0.3	-2.5	1.3	-1.8	-1.9	-0.0	-0.8	-1.3
Impedance of leg (left)	2.2	10.6	25.9	4.1	-3.5	-3.2	-3.5	-3.2	-3.6	-3.1	3.3	-0.8	-3.5	-3.2	3.8	-2.5	-0.2	-2.7	-4.2	0.7	5.1
Qualifications: A levels/AS levels or equivalent	2.2	5.0	8.6	2.9	-2.5	-2.5	-2.7	-2.7	-2.7	-2.5	2.7	-2.3	-2.6	-0.1	2.8	-2.1	1.4	-0.4	-1.5	1.0	1.9
Impedance of arm (left)	2.2	10.0	24.4	4.6	-3.6	-3.1	-3.5	-3.0	-3.9	-3.1	3.2	-0.3	-3.3	-2.4	4.1	-1.9	0.0	-1.8	-3.8	0.6	4.9
Glaucoma (self-reported)	2.2	2.5	6.5	1.9	-1.4	-1.6	-1.9	-1.7	-2.1	-1.3	1.4	-2.6	-1.8	-1.0	1.2	-1.3	-1.1	-1.6	-1.6	0.7	1.6
Diabetes (mother)	2.1	2.7	10.1	1.7	-1.7	-1.7	-1.9	-1.6	-0.8	-1.6	1.3	-1.8	-1.8	-1.6	1.0	-1.1	0.5	-1.3	-2.2	-0.9	3.2
Medication: Simvastatin	2.1	3.0	9.2	1.0	-1.5	-2.2	-2.1	-2.0	-1.2	-2.1	1.6	-3.0	-2.2	-0.0	0.4	-2.0	-0.6	-1.7	-2.6	0.2	1.2
Medication for cholesterol	2.1	3.3	10.6	-0.9	1.9	2.3	2.0	1.8	1.5	2.5	-1.9	3.2	2.1	1.2	-1.0	2.0	0.9	1.2	2.2	-0.7	-0.6
Number of self-reported non-cancer illnesses	2.1	3.7	6.7	1.5	-1.7	-2.1	-2.2	-2.1	-2.2	-2.2	2.2	-1.9	-2.1	-1.4	1.3	-2.1	-2.1	-1.7	-2.6	1.5	0.5
Basal cell carcinoma (self-reported)	2.1	2.4	7.2	-0.6	1.8	1.9	1.7	1.6	1.4	1.9	-2.1	2.7	1.9	0.6	-0.8	2.3	0.0	-0.6	1.6	-1.1	-0.4
Intelligence (Savage-Jansen 2018)	2.0	6.1	13.9	3.1	-2.9	-2.7	-2.9	-2.7	-0.9	-2.8	2.8	-2.8	-2.8	1.6	2.8	-2.0	1.4	-1.0	-2.2	-0.1	3.7
Hearing difficulty/problems: Yes	2.0	3.0	6.4	0.9	-2.5	-2.2	-2.2	-2.1	-1.5	-2.3	1.9	-2.5	-2.2	0.3	0.7	-2.1	-0.1	-0.5	-2.2	-0.2	1.0
Time employed in main current job	2.0	2.3	3.8	1.8	-1.5	-1.9	-1.8	-1.7	-1.5	-2.0	1.9	-1.5	-1.8	-1.0	1.5	-1.7	1.3	1.5	-0.9	0.8	0.3
Illnesses of father: None of the above (group 1)	2.0	2.5	4.5	-1.3	1.8	1.7	1.6	1.5	1.3	1.7	-2.1	2.0	1.7	1.8	-1.6	1.8	1.4	0.1	1.4	-1.7	0.6
Multivitamins +/- minerals	1.9	2.4	6.2	-1.5	1.1	1.7	1.7	1.5	1.0	1.8	-1.1	2.2	1.7	0.8	-1.2	1.1	0.1	2.4	2.5	-0.0	-1.7
Stomach or abdominal pain in last month	1.9	2.3	8.1	-0.2	1.0	1.0	1.2	1.2	1.3	0.7	-0.1	0.6	1.2	-2.7	-0.1	0.3	-0.9	2.8	2.0	2.1	-2.9
Loud music exposure frequency	1.9	2.0	6.8	1.8	-1.4	-1.2	-1.4	-1.3	-1.4	-1.0	1.2	-1.5	-1.4	0.3	1.8	-1.0	2.6	0.4	-1.2	0.0	2.2
Shortness of breath walking on level ground	1.9	2.3	5.8	-1.4	1.7	1.8	1.6	1.2	2.4	2.0	-1.8	1.5	1.6	-0.3	-1.6	1.3	-0.2	0.5	1.4	0.1	-2.2
Deep venous thrombosis (DVT) (self-reported)	1.9	2.5	4.5	1.9	-2.0	-1.9	-1.7	-1.6	-0.9	-1.9	2.0	-1.4	-1.7	-0.8	2.0	-1.8	-0.8	0.4	-1.4	2.1	0.4
Chronic bronchitis/emphysema (mother)	1.8	2.1	8.2	-1.8	1.0	1.5	1.9	1.8	2.9	1.4	-1.3	1.0	1.7	-1.3	-1.4	1.1	-0.5	-0.5	1.3	-0.2	-1.2
Age at First Birth	1.7	2.4	5.8	-1.1	1.7	1.8	1.6	1.5	-0.1	2.0	-1.8	1.6	1.7	1.9	-1.4	2.4	1.2	0.2	1.1	-2.0	0.7
Hypothyroidism/myxoedema (self-reported)	1.7	3.3	7.5	1.7	-1.7	-2.3	-2.6	-2.7	-2.1	-2.0	1.7	-2.1	-2.5	-0.7	1.1	-2.2	0.9	-0.5	-1.7	0.2	1.2
Loneliness, isolation	1.7	2.4	5.4	-2.0	1.6	1.7	1.7	1.3	1.9	1.7	-1.6	1.1	1.8	0.1	-1.8	1.2	-1.1	1.0	1.6	0.1	-2.3
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.9	4.9	-1.6	1.4	1.5	1.3	1.2	0.9	1.4	-1.5	1.5	1.4	2.2	-1.6	1.1	-0.7	0.5	1.8	-0.7	-1.1
Pain type(s) experienced in last month: Hip pain	1.7	2.2	5.8	-1.6	1.0	1.6	1.6	1.2	0.7	1.6	-1.2	0.9	1.4	1.3	-1.5	1.0	1.0	2.4	2.1	-0.4	-2.4
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	6.5	-1.2	1.4	1.6	1.7	1.8	1.3	1.2	-0.9	1.5	2.0	1.0	-0.3	1.5	-2.5	-0.6	1.3	0.8	-1.7
Hair/balding pattern: Pattern 3	1.6	2.4	5.6	0.4	1.6	1.9	2.0	1.9	2.4	1.9	-1.6	1.5	1.9	0.0	0.6	1.6	1.4	1.1	2.3	0.2	-0.5
Illnesses of mother	1.6	2.0	5.2	-1.7	1.6	1.4	1.4	1.5	0.0	1.6	-1.3	2.3	1.3	1.8	-1.8	1.4	0.1	0.5	1.5	-0.8	-1.4
Blood clot in the leg (DVT)	1.6	2.1	4.2	1.8	-1.8	-1.6	-1.5	-1.4	-0.9	-1.7	1.8	-1.2	-1.5	-0.7	1.7	-1.6	-1.1	0.3	-1.5	2.0	0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.2	8.4	1.3	-1.5	-1.9	-2.0	-1.8	-1.7	-1.9	1.8	-1.4	-2.0	-0.1	0.9	-1.4	-0.9	-2.8	-2.9	-0.6	2.6
High cholesterol (Self-reported)	1.6	2.8	6.0	1.2	-1.6	-2.0	-2.0	-2.1	-1.2	-1.9	1.8	-2.5	-2.1	-0.8	1.0	-1.9	-0.9	-1.6	-2.2	1.3	0.1
Commuting to job workplace: Cycle	1.6	1.9	4.5	1.8	-2.0	-1.5	-1.4	-1.4	-0.3	-1.5	1.6	-1.1	-1.5	-0.1	1.8	-1.3	-0.0	-0.7	-1.5	0.4	2.1
Bipolar Disorder (2018)	1.5	2.3	5.7	-2.4	1.3	1.7	1.7	1.4	0.9	1.7	-1.8	1.7	1.7	-0.2	-2.1	1.6	0.0	-0.6	1.9	-1.5	-0.6
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	4.7	2.2	-0.9	-0.9	-1.3	-1.4	-0.9	-0.7	1.2	-1.5	-1.4	-2.1	1.8	-1.1	-0.1	0.2	-1.4	1.1	0.2
Townsend deprivation index at recruitment	1.5	2.1	5.2	-1.9	2.0	1.3	1.6	1.7	0.8	1.1	-1.0	-0.4	1.7	1.0	-1.8	0.9	-1.9	-0.1	1.3	0.1	-2.3
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	7.3	2.7	-1.1	-0.9	-1.1	-0.9	-1.7	-0.9	1.2	-0.5	-1.0	-1.7	2.2	-1.1	-0.4	-0.1	-0.5	2.1	0.6
Medication: Ibuprofen	1.5	1.8	4.4	-1.9	1.1	1.4	1.2	1.1	0.0	1.4	-1.4	1.3	1.4	0.8	-2.0	1.3	-2.1	-1.9	0.6	-0.6	-0.8
Illnesses of father: Heart disease	1.5	2.1	3.8	1.6	-1.5	-1.6	-1.6	-1.7	0.0	-1.4	1.8	-1.5	-1.7	-1.6	1.5	-1.9	-0.5	0.7	-0.6	1.8	-1.0
Average weekly champagne plus white wine intake	1.5	2.1	6.6	-1.2	1.9	1.7	1.4	1.2	0.3	1.8	-1.6	2.6	1.6	0.9	-1.1	1.9	-1.1	-1.3	0.6	-1.1	0.2
Eye problems/disorders: Glaucoma	1.5	1.7	4.0	1.5	-1.0	-1.3	-1.7	-1.6	-1.8	-1.1	1.4	-2.0	-1.6	-1.4	0.9	-1.4	-0.4	-0.8	-1.1	0.8	0.8
Crohns Disease (2012)	1.4	2.2	8.7	-2.3	1.2	1.0	0.6	0.7	-0.0	1.2	-1.9	-0.2	0.9	2.1	-2.7	1.5	0.4	-1.4	0.7	-3.0	0.4
Waist Hip Ratio (WHR)	1.4	6.2	16.0	2.6	-2.7	-2.7	-2.8	-2.4	0.6	-2.8	2.4	-2.0	-2.7	-2.1	2.8	-1.8	-1.6	-2.0	-3.6	0.5	4.0
Medication: Lisinopril	1.4	1.8	6.2	0.5	-1.0	-1.2	-1.4	-1.4	-1.2	-1.1	0.9	-2.5	-1.2	-1.2	0.4	-0.9	-1.0	-2.4	-2.1	-0.0	1.0
Coronary Artery Disease (CAD)	1.3	1.5	5.7	0.8	-0.3	-0.6	-1.0	-0.9	-1.0	-0.5	0.3	-0.2	-1.0	-2.1	0.4	-0.8	-2.3	-1.7	-2.4	0.8	1.5
Fasting Glucose	1.3	1.6	4.9	-0.9	1.2	1.3	1.5	1.4	2.2	1.2	-1.1	1.6	1.4	0.0	-1.3	1.1	0.5	0.7	1.9	-0.7	-1.0
HbA1C	1.3	1.4	3.3	0.8	-1.5	-1.8	-1.5	-1.4	-0.2	-1.7	1.5	-1.5	-1.5	0.3	0.6	-1.7	0.3	0.1	-1.0	0.9	-0.7
Medication: Levothyroxine sodium	1.3	2.2	5.4	1.0	-1.4	-1.9	-2.1	-2.3	-2.0	-1.6	1.4	-1.6	-2.1	-0.4	0.5	-1.9	1.3	-0.1	-1.4	-0.0	0.5
Health satisfaction	1.3	1.7	7.4	-1.8	1.0	1.2	1.2	1.1	1.8	1.1	-1.1	0.2	1.2	-0.2	-1.9	0.5	0.3	1.1	1.5	-0.5	-2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	3.5	-0.4	-1.4	-1.4	-1.7	-1.9	-1.8	-1.3	1.3	-0.8	-1.5	-0.5	-1.0	-1.5	-1.0	-0.8	-1.3	-0.1	-1.0
Smoking status: Previous	1.3	1.9	7.6	-2.1	1.8	1.2	1.2	1.1	1.2	1.3	-1.1	0.5	1.1	2.8	-1.9	0.7	-0.2	0.5	1.1	-0.9	-1.7
Pain experienced in last month	1.3	2.2	7.8	1.4	-1.3	-1.8	-1.8	-1.5	-0.5	-1.7	1.3	-1.3	-1.9	0.4	0.9	-1.3	2.8	-0.6	-1.5	-1.0	2.1
Chronotype (morning person)	1.2	2.7	9.9	-0.6	-0.4	0.2	-0.3	0.0	-2.7	0.4	-1.2	2.8	-0.1	0.8	-1.1	1.3	0.4	-2.5	-0.7	-3.1	3.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	5.6	-0.6	1.4	1.3	1.4	1.2	2.4	1.3	-1.0	0.6	1.4	-0.8	-0.1	0.9	1.1	2.1	1.8	0.1	-1.0
Sitting height	1.2	8.2	15.3	2.9	-3.0	-3.7	-3.8	-3.9	-3.6	-3.4	3.0	-1.1	-3.8	-1.6	1.9	-2.9	-0.1	-1.6	-3.6	0.8	2.6
Length of working week for main job	1.2	1.3	4.9	-1.4	1.0	1.2	0.9	1.1	1.8	1.3	-1.4	0.6	1.0	-0.3	-1.3	0.7	-1.3	-2.2	0.3	-0.3	-0.5
Emphysema/chronic bronchitis	1.2	1.4	3.8	0.8	-1.5	-1.2	-0.8	-1.1	-0.2	-1.2	1.2	-1.0	-0.9	-1.9	0.6	-1.7	0.1	1.1	0.1	1.5	-1.9
Lupus	1.1	1.6	7.3	-0.8	0.8	0.9	1.2	0.9	1.1	0.8	-0.6	1.3	1.1	-1.6	-1.2	0.5	1.0	2.0	1.9	0.2	-2.7
Rheumatoid Arthritis	1.1	1.5	7.8	1.5	-0.8	-0.7	-0.5	-0.5	-0.2	-0.8	1.2	-1.4	-0.6	-0.4	1.8	-1.2	-1.5	1.5	0.1	2.8	-1.4
Blood White Count	1.1	8.4	33.6	2.1	-3.6	-3.7	-3.4	-3.4	-1.1	-3.9	3.2	-5.8	-3.2	-0.1	2.1	-3.2	-0.6	0.0	-2.7	1.6	1.1
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	9.2	0.4	-0.1	-0.1	0.0	-0.4	0.4	-0.1	0.7	-0.7	-0.1	-1.9	1.2	-0.3	2.0	3.0	1.7	1.1	-1.7
Number of incorrect matches in round	1.1	1.7	8.2	-2.6	0.8	0.4	0.2	-0.1	-0.5	0.6	-0.9	0.7	0.2	-0.9	-2.9	0.4	-0.9	-2.7	-1.2	-1.6	-0.5
Medication: Cholesterol lowering	1.1	1.7	4.7	1.0	-1.2	-1.5	-1.5	-1.5	-0.9	-1.4	1.3	-2.2	-1.6	-1.3	0.8	-1.5	-0.7	-0.7	-1.8	1.0	0.3
High blood pressure (siblings)	1.1	1.5	4.7	0.3	-0.7	-1.4	-1.4	-1.3	-1.7	-1.4	1.1	-2.2	-1.3	0.6	0.6	-0.8	-0.6	-1.5	-1.6	-0.3	1.7
Number of full brothers	1.1	1.3	8.6	-0.5	0.4	0.5	0.9	0.9	1.5	0.4	-0.5	-0.5	0.6	-0.1	-1.1	0.2	2.9	1.8	1.6	-1.3	-1.1
Wheeze or whistling in the chest in last year	1.1	1.9	6.0	-2.5	0.6	1.4	1.3	1.0	0.8	1.2	-1.1	1.4	1.4	-0.2	-2.1	0.7	-2.1	-0.6	0.9	0.1	-2.4
Eye problems/disorders: None of the above	1.1	1.3	6.5	-1.5	0.7	1.1	1.3	1.1	0.8	1.1	-1.3	0.8	1.2	2.6	-1.2	1.2	-0.1	-0.4	0.6	-0.8	-0.5
Family relationship satisfaction	1.1	1.3	2.9	-1.4	1.5	1.3	1.3	1.1	1.1	1.4	-1.2	0.8	1.3	0.2	-1.5	0.8	0.2	0.5	1.1	-0.6	-1.7
Alzheimer’s Disease (in father)	1.0	1.0	3.1	-0.9	1.2	1.1	0.8	0.3	-0.9	1.4	-1.3	0.8	0.8	1.8	-1.0	1.2	0.7	0.2	1.0	-1.2	-0.4
Mean Putamen Volume	1.0	1.1	2.6	0.9	-0.5	-1.2	-1.4	-1.4	-1.3	-1.1	0.8	-0.5	-1.3	1.2	0.5	-1.0	-0.1	-1.0	-1.6	-0.3	1.0
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	5.5	0.1	-0.7	-1.1	-1.2	-1.2	-2.3	-1.1	1.1	-0.0	-1.0	0.4	0.0	-0.9	-1.6	-1.4	-1.4	0.1	0.8
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	3.2	-0.2	0.4	1.0	1.2	1.1	1.8	1.0	-1.2	1.3	1.2	0.6	-0.5	1.1	0.6	1.4	1.5	0.3	-0.8
Financial difficulties in last 2 years	1.0	1.3	3.5	-0.5	1.4	1.3	1.4	1.2	0.3	1.2	-0.8	-0.3	1.4	-1.2	0.1	0.7	-1.3	0.6	1.0	1.9	-1.8
Medication: Lansoprazole	1.0	1.2	12.1	-1.0	-0.1	-0.2	-0.2	-0.0	-0.0	-0.3	0.1	-0.2	-0.0	-0.3	-0.7	-0.2	-3.5	-2.2	-1.3	0.6	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	8.1	0.3	0.4	0.7	0.9	0.7	1.6	0.8	0.1	0.9	0.7	-0.7	0.3	0.4	0.7	2.8	1.5	1.3	-1.8
Miserableness	1.0	1.8	10.5	-1.2	1.4	1.2	1.2	0.9	1.1	1.3	-1.2	0.7	1.1	-0.2	-1.6	0.3	-1.6	0.8	0.7	1.5	-3.2
Medication: Atorvastatin	1.0	1.2	4.3	1.2	-1.0	-1.1	-0.8	-0.9	0.5	-1.0	1.4	-1.1	-0.9	-2.1	1.5	-1.2	-0.4	-0.3	-0.5	1.6	-0.7
Verbal and Numeric Reasoning (VNR)	0.9	2.2	13.6	2.2	-1.3	-1.1	-1.5	-1.3	-0.1	-1.1	1.3	-0.8	-1.3	1.0	2.2	-0.2	0.8	-1.1	-1.3	-0.6	3.7
Neuroticism (2016)	0.9	1.3	2.9	0.9	-1.3	-1.4	-1.2	-1.2	-0.2	-1.3	1.5	-1.7	-1.3	-0.7	1.3	-1.6	-0.3	0.3	-0.6	1.4	-0.6
Medication: Atenolol	0.9	1.1	2.8	-1.0	1.7	1.2	0.8	0.6	1.1	1.3	-1.3	1.2	0.9	-1.3	-1.3	1.2	0.5	-0.6	0.4	-1.2	0.1
Had menopause	0.9	1.1	3.4	0.9	-0.6	-1.1	-1.1	-1.3	-0.6	-1.1	1.2	-0.2	-1.0	-0.7	1.0	-1.5	-0.2	1.8	-0.2	1.7	-0.8
Father’s age at death	0.9	1.2	5.1	2.2	0.4	-0.2	-0.2	-0.4	-0.2	-0.3	0.8	1.1	-0.3	-2.3	2.2	-0.3	0.2	0.9	0.1	1.9	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.9	0.7	-0.9	-1.0	-1.0	-0.9	-0.2	-0.9	0.8	-1.8	-1.1	1.3	0.6	-0.9	2.0	0.5	-0.3	-0.8	0.9
Hair/balding pattern: Pattern 4	0.9	2.2	7.2	-2.6	1.9	1.3	1.2	0.9	0.7	1.5	-1.5	1.1	1.2	1.0	-2.7	1.1	-0.3	-0.6	0.9	-1.1	-2.1
Ever highly irritable/argumentative for 2 days	0.9	1.1	4.8	-1.3	1.3	0.8	1.1	1.0	2.2	0.7	-0.8	0.6	1.0	0.5	-1.2	0.2	-0.6	-0.9	0.7	-0.0	-1.9
Number of children fathered	0.9	1.1	2.3	-1.5	0.1	0.6	0.9	1.0	0.9	0.5	-0.8	1.0	0.7	1.3	-1.5	0.7	1.5	1.0	1.3	-1.4	-0.6
Chest pain or discomfort	0.9	1.3	4.8	-2.2	0.9	1.1	0.6	0.3	0.1	1.2	-1.4	1.5	0.8	0.1	-2.0	0.9	0.6	-1.1	0.3	-1.7	-0.4
Knee pain experienced in last month	0.9	1.4	3.3	-1.5	1.5	1.4	1.2	1.1	0.6	1.3	-1.5	-0.3	1.3	1.0	-1.6	1.1	-1.0	0.2	0.8	-0.2	-1.8
Friendships satisfaction	0.9	1.1	3.5	-0.5	0.8	0.9	1.1	0.9	1.9	0.8	-0.6	0.4	1.1	-1.2	-0.4	0.5	0.7	1.8	1.5	0.5	-1.4
Qualifications: nursing, teaching	0.9	1.4	2.7	1.0	-1.1	-1.4	-1.4	-1.2	-1.4	-1.5	1.6	-1.3	-1.5	-0.8	0.9	-1.7	0.7	0.3	-0.6	1.1	-0.1
Wears glasses or contact lenses	0.9	1.0	8.0	0.9	-0.1	0.2	0.3	0.4	0.2	0.2	-0.1	0.5	0.2	1.6	1.0	0.9	2.8	0.4	0.8	-1.2	1.6
Depressed Affect (Nagel 2018)	0.8	1.7	9.4	-1.8	1.1	0.9	1.0	0.6	1.6	0.9	-1.0	1.0	0.9	-0.7	-2.2	0.1	-1.0	0.6	1.0	0.6	-3.1
Supplements: Zinc	0.8	0.9	3.6	-0.8	1.0	0.9	1.1	1.2	0.7	1.1	-1.0	0.3	1.0	-0.5	-0.7	0.7	-0.2	0.9	1.9	-0.5	-0.9
Qualifications: CSEs or equivalent	0.8	1.1	5.5	-1.1	0.0	0.0	-0.1	0.0	1.0	0.0	-0.3	-0.4	-0.1	-2.2	-1.3	-0.2	-2.3	-1.4	-1.3	0.3	-0.9
Body mass index (BMI)	0.8	3.6	13.8	-2.7	1.7	1.5	1.6	1.3	2.9	1.4	-1.7	-1.1	1.6	2.1	-2.5	0.5	-1.1	1.2	1.6	0.6	-3.7
Breastfed as a baby	0.8	0.9	6.2	1.3	0.1	-0.6	-0.7	-0.5	-0.6	-0.3	0.6	-1.0	-0.8	-0.1	1.3	-0.4	2.5	1.7	0.4	-0.2	0.8
Tense / ‘highly strung’	0.8	1.3	3.4	-1.9	1.3	1.2	1.2	1.0	0.3	1.2	-1.1	1.6	1.2	0.2	-1.3	1.0	-1.5	-1.4	0.5	-0.3	-0.9
Age at first live birth	0.8	1.4	6.4	1.3	-1.6	-0.9	-1.1	-1.0	-2.0	-0.8	1.0	-0.2	-1.1	0.3	1.7	-0.1	0.6	-0.3	-1.3	-0.2	2.5
Qualifications: College or University degree	0.8	2.5	10.7	2.7	-1.6	-1.4	-1.2	-1.1	-1.1	-1.5	2.1	0.3	-1.2	-0.5	3.3	-0.8	1.6	0.5	-0.4	0.8	2.5
Overall health rating	0.8	1.7	9.8	-1.8	1.1	0.6	0.9	0.8	1.6	0.3	-0.5	-1.2	0.9	-0.2	-1.6	-0.2	-2.3	-0.6	0.5	1.1	-3.1
Leg pain on walking	0.8	1.0	4.2	-0.5	1.0	0.9	1.0	0.7	1.4	0.9	-0.4	0.9	0.9	-0.8	-0.1	0.4	0.4	2.0	1.7	0.4	-1.5
Supplements: Vitamin C	0.8	0.9	2.4	-1.5	0.8	0.8	0.7	0.6	0.7	0.9	-1.2	0.7	0.8	1.2	-1.3	1.2	-0.1	-0.1	0.6	-1.5	0.6
Illnesses of siblings: Diabetes	0.8	1.0	2.2	1.1	-1.1	-1.1	-1.1	-1.3	-0.5	-1.0	1.0	-1.4	-1.2	-1.5	1.0	-1.3	-0.0	0.1	-1.0	0.5	0.5
Commuting to job workplace: Walk	0.8	0.9	1.9	0.9	-0.7	-0.9	-0.9	-1.1	-0.9	-0.9	0.9	-0.6	-0.8	1.3	1.1	-1.2	-0.9	0.7	-0.4	1.4	-0.9
Mother’s age at death	0.8	1.0	4.7	1.8	0.2	-0.1	0.1	-0.2	-0.9	-0.0	0.8	0.6	-0.1	-0.4	2.2	-0.1	1.4	1.9	0.8	1.5	0.4
Tinnitus: Yes, now most or all of the time	0.8	0.9	4.1	-0.6	0.7	0.3	0.3	0.5	0.2	0.5	-1.0	0.4	0.3	0.9	-0.6	1.3	-0.3	-2.0	-1.0	-1.6	1.5
Heart disease (siblings)	0.8	1.0	3.7	-1.8	0.4	0.7	0.7	0.7	1.3	0.4	-1.2	0.5	0.8	0.1	-1.9	0.5	0.5	0.3	1.2	-1.1	-1.2
Prostate Cancer	0.7	0.9	3.1	-0.4	1.3	1.0	0.8	0.7	0.1	1.2	-1.1	0.9	0.7	0.0	-0.6	1.3	1.8	-0.5	0.5	-1.5	1.1
LDL Cholesterol	0.7	1.1	2.8	1.1	-1.2	-1.4	-1.1	-0.8	-1.7	-1.3	1.3	-1.0	-1.1	-0.2	1.2	-1.0	-0.1	1.1	-0.7	1.1	0.2
Lung FEV1/FVC ratio	0.7	3.6	16.6	1.5	-0.7	-1.3	-1.4	-1.7	0.4	-1.3	2.0	-2.2	-1.4	-4.1	1.3	-2.4	-0.7	1.1	-0.3	3.0	-3.0
Frequency of depressed mood in last 2 weeks	0.7	0.9	6.0	0.1	-0.2	-0.1	0.1	-0.2	0.7	-0.0	0.4	-0.7	-0.0	-1.5	0.2	-0.8	0.7	2.5	1.2	1.1	-2.0
Ever had hysterectomy (womb removed)	0.7	0.7	2.2	0.3	1.5	1.1	1.0	1.0	0.7	1.0	-0.9	0.6	1.1	0.5	0.0	0.9	0.4	1.1	1.3	-0.2	-0.1
Pulse wave peak to peak time	0.7	0.9	2.0	0.9	-0.6	-0.9	-0.7	-0.8	-1.3	-1.0	1.2	-0.5	-0.8	-1.3	0.7	-1.2	-0.4	-0.3	-0.2	1.3	-1.4
Angina (self-reported)	0.7	0.9	6.4	-1.2	0.7	0.4	0.5	0.5	2.5	0.2	-0.4	-0.6	0.5	-1.1	-0.9	-0.0	-0.4	0.5	0.8	0.3	-2.0
Medication: Allopurinol	0.7	1.0	2.7	0.5	-0.6	-1.0	-1.0	-0.8	-0.7	-1.0	0.9	-0.6	-1.0	-0.7	0.1	-1.6	-1.5	-0.5	-1.1	1.5	-1.2
Pulse rate, automated reading	0.7	2.1	10.0	0.8	0.8	1.0	1.3	1.4	1.1	0.7	0.1	0.6	1.3	-1.6	1.6	0.3	-2.0	1.7	1.1	3.2	-2.4
Age at last live birth	0.7	1.0	3.3	1.5	-1.2	-0.8	-1.0	-0.9	-1.1	-0.8	1.1	0.0	-1.0	0.6	1.8	-0.4	-0.1	-0.6	-1.2	0.7	1.2
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	6.0	0.6	0.4	0.7	0.9	1.1	1.2	0.6	-0.5	0.3	0.9	0.2	0.3	0.6	0.7	2.5	1.7	1.2	-1.7
Osteoarthritis (self-reported)	0.7	0.9	3.0	-1.2	1.2	0.9	0.9	0.8	-0.2	0.9	-0.5	0.8	0.9	1.1	-1.7	0.7	-1.0	0.1	0.8	-0.4	-1.7
Supplements: Calcium	0.7	0.8	3.9	-0.6	0.5	0.6	1.0	0.8	2.0	0.7	-0.2	0.5	0.8	-1.3	-0.3	0.0	0.6	0.8	1.2	0.6	-1.1
Depression (Nagel 2018)	0.6	0.9	4.0	0.0	0.6	0.4	0.4	-0.1	1.5	0.5	-0.2	0.5	0.2	-2.0	-0.1	-0.4	1.0	1.9	1.0	0.6	-1.4
Schizophrenia vs Biploar Disorder	0.6	0.8	2.0	-0.9	1.4	1.0	1.0	1.0	1.4	0.9	-0.8	0.9	0.9	-0.2	-1.0	0.9	-0.7	-0.8	0.4	-0.1	-1.0
Alzheimer’s Disease (in mother)	0.6	0.7	4.1	1.0	0.8	0.3	0.3	0.0	0.4	0.4	0.4	0.3	0.3	-2.0	1.2	-0.3	-0.3	0.5	0.0	1.8	-0.9
BMI	0.6	3.4	18.5	-2.2	1.0	1.1	1.3	1.0	3.5	0.8	-0.9	-1.7	1.3	1.3	-1.5	-0.0	-0.5	2.2	2.2	1.4	-4.3
Angina	0.6	0.8	6.1	-1.0	0.6	0.2	0.4	0.4	2.5	0.1	-0.2	-0.8	0.3	-1.0	-0.8	-0.2	-0.2	0.6	0.8	0.4	-1.9
Diabetes (father)	0.6	0.8	6.4	0.3	-0.7	-0.5	-0.6	-0.3	-1.3	-0.7	0.3	-0.4	-0.6	-0.4	0.3	0.3	-0.5	-0.7	-1.2	-1.2	2.5
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	5.1	-2.0	0.8	0.9	0.8	0.7	0.6	0.8	-1.4	0.8	0.8	0.9	-1.8	0.8	-1.1	-2.3	-0.4	-1.5	-0.1
Serious illness, injury or assault to yourself	0.6	0.7	2.4	0.7	-0.3	-0.9	-0.8	-0.8	0.1	-1.0	1.0	-1.2	-0.8	-1.5	0.7	-0.8	0.8	1.2	0.1	0.3	-0.8
Falls in the last year	0.6	0.9	4.2	-0.9	1.0	0.6	0.6	0.5	1.1	0.6	-0.6	-0.2	0.7	0.5	-1.4	-0.0	0.3	1.6	1.3	0.2	-2.0
Number of live births	0.6	0.9	3.5	1.9	-0.7	-0.7	-0.8	-1.0	0.4	-0.5	0.6	-0.1	-0.9	-1.1	1.4	-0.9	1.0	1.5	0.1	0.8	-0.2
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	4.6	2.1	-1.7	-1.4	-1.4	-1.4	-2.1	-1.4	1.7	-1.6	-1.4	-0.4	1.9	-1.1	0.9	-0.1	-0.9	0.9	1.3
Asthma	0.6	1.2	6.6	0.2	-1.0	-0.7	-0.7	-0.6	-1.0	-0.7	1.1	0.0	-0.5	-0.5	0.6	-1.0	-2.6	-0.3	-1.1	2.1	-1.4
Medication for pain relief, constipation, heartburn	0.6	1.1	4.2	1.4	-1.2	-0.9	-0.9	-0.7	-0.1	-0.9	1.1	-0.5	-0.9	0.3	2.0	-0.5	0.6	-0.0	-1.2	0.6	2.0
Neck or shoulder pain in last month	0.6	0.9	2.6	-0.7	1.6	1.4	1.2	1.2	0.7	1.4	-1.0	0.2	1.2	0.0	0.1	1.2	-0.2	0.7	1.2	-0.1	-0.4
Medication: Seretide 50 evohaler	0.6	0.7	2.9	-0.4	0.7	0.7	0.6	0.4	0.0	0.8	-0.3	0.9	0.7	1.4	-0.2	0.6	0.4	1.6	0.9	0.5	-1.7
Heart disease (mother)	0.6	0.8	1.5	0.5	-0.6	-1.0	-1.1	-1.1	-1.0	-0.9	0.9	-0.8	-1.0	-1.2	0.7	-1.0	-0.4	-0.9	-1.1	0.2	0.8
Commuting to job workplace: Car/motor vehicle	0.6	0.7	3.4	-1.2	0.2	-0.1	0.1	0.3	0.4	-0.3	-0.2	-0.1	0.0	-0.3	-1.8	-0.4	-1.4	-1.6	-0.5	-0.3	-1.2
Mood swings	0.6	1.0	5.0	-2.0	0.6	0.3	0.5	0.5	1.5	0.3	-0.5	-0.1	0.4	-0.5	-1.8	-0.1	-1.5	0.1	0.3	0.3	-2.2
Asthma (self-reported)	0.6	1.3	6.6	0.2	-1.1	-0.8	-0.7	-0.7	-1.0	-0.8	1.2	-0.0	-0.6	-0.4	0.7	-1.1	-2.6	-0.3	-1.1	2.2	-1.5
Age started oral contraceptive pill	0.6	0.8	4.0	0.4	0.1	0.1	0.4	0.2	-0.0	-0.0	0.4	1.0	0.3	-1.5	1.1	-0.0	0.8	2.0	1.0	1.4	-1.1
Myopia	0.6	0.9	3.7	0.0	-0.9	-0.5	-0.5	-0.5	-0.1	-0.4	0.2	-1.2	-0.5	1.3	-0.4	0.1	0.7	-1.4	-1.0	-1.8	1.9
Bipolar Disorder (2011)	0.5	0.5	1.3	-0.1	0.3	0.9	0.8	0.9	1.1	0.8	-0.9	0.7	0.8	-0.6	-0.1	0.7	0.5	0.5	0.6	-0.5	0.9
Primary Biliary Cirrhosis	0.5	0.8	3.0	-0.8	0.9	0.2	0.4	0.2	1.1	0.2	-0.4	0.0	0.4	-0.2	-1.2	0.2	1.7	0.8	1.6	-0.9	-1.3
Number of treatments/medications taken	0.5	0.8	2.9	0.6	-0.2	-0.7	-0.9	-0.9	-1.1	-0.5	0.6	-0.9	-0.8	-1.6	0.1	-0.6	-1.7	-0.9	-1.5	0.7	0.4
Relative age of first facial hair	0.5	1.0	5.0	-0.1	0.1	0.4	0.4	0.6	0.4	0.4	0.2	1.4	0.3	-1.9	0.3	-0.2	0.6	2.2	1.6	0.6	-1.6
Average weekly fortified wine intake	0.5	0.6	8.3	-0.7	-0.1	0.1	0.2	0.1	-0.8	0.1	-0.0	0.0	0.2	2.9	-0.5	0.4	0.2	-0.8	-0.1	-0.4	0.4
Relative age voice broke	0.5	0.7	3.7	0.5	-0.0	0.3	0.6	0.6	1.0	0.4	0.3	1.4	0.5	-1.2	1.1	0.3	1.2	1.9	0.9	0.3	-0.3
Chronic bronchitis/emphysema (father)	0.5	0.5	3.6	-0.9	-0.3	-0.5	-0.0	0.1	0.5	-0.7	0.5	-0.5	-0.2	-0.8	-0.8	-0.8	-0.9	0.7	0.3	0.6	-1.9
Trunk fat mass	0.5	2.2	7.0	0.6	-1.2	-1.6	-1.8	-1.8	-0.3	-1.7	1.2	-2.6	-1.6	0.5	0.1	-1.9	-2.0	-0.5	-2.0	1.5	-0.8
Hearing difficulty/problems with background noise	0.5	0.8	3.8	-1.0	-0.7	-0.1	-0.3	-0.5	-0.2	-0.1	-0.3	-1.9	-0.3	1.8	-1.6	-0.7	0.4	0.5	0.2	-0.9	-1.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.9	-1.0	0.6	0.8	0.7	0.4	1.2	1.0	-0.7	0.8	0.7	1.4	-0.8	0.6	-0.0	-0.8	0.4	-0.2	-0.4
Pulse rate	0.5	0.8	3.5	0.9	0.4	0.3	0.6	0.8	0.9	-0.1	0.8	-0.1	0.7	0.3	1.5	-0.0	-0.2	1.9	1.2	1.8	-0.5
Lung cancer (father)	0.5	0.6	2.8	-0.8	-0.2	-0.6	-0.4	-0.3	-1.2	-0.6	0.2	-1.7	-0.5	0.7	-1.0	-0.5	0.3	0.4	-0.3	-1.2	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	5.8	1.7	-1.6	-1.3	-1.4	-1.2	-2.4	-1.3	1.5	-1.8	-1.2	0.2	1.3	-0.9	0.0	-0.7	-1.0	0.5	1.3
Pulse wave Arterial Stiffness index	0.5	0.5	3.9	-0.5	-0.0	0.2	-0.0	0.1	0.7	0.3	-0.6	-0.0	0.1	1.2	-0.5	0.7	0.3	-0.3	-0.6	-1.3	2.0
Peak expiratory flow (PEF)	0.5	1.2	2.7	1.4	-1.2	-1.2	-1.1	-1.0	-0.7	-1.2	1.5	-1.6	-1.1	0.6	1.3	-1.2	0.5	0.5	-0.1	1.0	-0.4
Medication: Ventolin 100micrograms inhaler	0.5	0.7	4.7	-0.3	0.7	0.4	0.4	0.2	-0.4	0.4	-0.1	0.8	0.4	-0.6	0.1	-0.0	-2.2	-0.2	-0.2	1.5	-1.7
Leg fat percentage (right)	0.5	1.7	7.4	-0.2	-0.8	-1.0	-1.1	-1.3	0.7	-1.1	0.7	-2.7	-1.0	-0.1	-0.4	-1.7	-2.2	-0.5	-1.5	1.8	-1.5
Comparative body size at age 10	0.5	1.3	7.2	1.5	0.0	-0.2	0.0	-0.2	1.9	-0.1	0.5	-1.5	-0.1	0.9	1.4	-0.3	1.7	2.7	1.1	1.2	-0.5
Migraine (self-reported)	0.5	0.6	6.8	0.6	0.3	0.1	-0.1	-0.4	-0.3	0.1	0.2	0.4	-0.0	-2.6	0.4	-0.2	-0.4	-0.2	-0.5	1.2	-0.9
Mean time to correctly identify matches	0.5	1.0	3.5	-1.6	0.2	0.6	0.7	0.6	1.3	0.4	-0.8	0.2	0.8	0.7	-1.8	0.7	1.1	0.6	1.4	-1.9	0.1
Number of full sisters	0.5	0.6	2.8	-1.3	0.2	0.0	0.1	-0.0	-1.5	0.1	-0.6	-0.2	0.1	1.7	-1.3	0.2	0.0	-0.6	0.1	-0.9	0.0
Suffer from ‘nerves’	0.5	0.8	3.4	-0.9	0.3	0.3	0.2	0.0	-1.1	0.4	-0.6	0.8	0.1	1.8	-0.7	0.3	-1.1	-1.6	-1.2	-0.6	0.7
Had major operations	0.5	0.6	1.6	1.2	-0.8	-0.7	-0.6	-0.6	-1.1	-0.8	1.0	-1.3	-0.8	-0.0	0.7	-0.8	0.1	-0.2	-0.1	0.6	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	3.5	-0.4	-0.1	-0.0	0.4	0.6	1.9	-0.2	0.1	-0.3	0.2	-0.2	-0.2	-0.3	-1.4	0.5	-0.4	1.2	-1.4
Hearing aid user	0.5	0.5	2.7	-1.3	0.1	0.3	0.1	0.3	-0.1	0.3	-0.7	0.0	0.1	0.7	-1.6	0.0	0.2	-0.9	-0.9	-1.5	-0.2
Commuting to job workplace: Public transport	0.5	0.6	1.7	-0.4	0.8	0.8	0.7	0.6	1.2	0.7	-0.7	0.6	0.8	1.2	-0.6	-0.1	-0.6	-0.4	0.8	0.7	-1.3
Alzheimer’s Disease (including proxy)	0.4	0.5	3.5	0.6	0.1	-0.4	-0.6	-1.1	-0.8	-0.2	0.7	0.2	-0.5	-1.9	1.3	-0.4	0.3	0.0	-0.7	0.7	0.3
Breast Cancer	0.4	1.0	5.9	2.3	-0.0	-0.5	-0.4	-0.5	-0.2	-0.3	0.7	-0.0	-0.6	-0.8	2.4	-0.3	0.1	1.4	-0.3	1.3	0.4
Allergy or Eczema	0.4	1.0	6.2	-1.1	0.5	0.8	0.8	1.0	-0.7	0.8	-0.7	0.7	0.8	2.5	-0.9	0.8	0.5	0.9	1.0	-0.8	-0.6
Respiratory disease	0.4	1.0	4.0	-0.7	-1.1	-0.8	-0.6	-0.7	-0.9	-0.8	1.0	-0.3	-0.6	-0.9	-0.4	-1.1	-1.2	1.2	0.1	1.5	-2.0
Ever used hormone-replacement therapy (HRT)	0.4	0.5	3.1	-1.4	0.1	-0.1	0.1	0.1	0.0	-0.3	0.1	0.0	0.2	0.7	-1.2	-0.2	-0.7	1.2	0.6	0.4	-1.8
Severe depression (siblings)	0.4	0.4	2.3	-0.8	0.7	0.4	0.2	-0.1	0.1	0.4	-0.5	0.1	0.2	-0.2	-1.5	0.2	-0.4	-1.5	0.0	-1.0	-0.4
Trunk fat percentage	0.4	1.6	4.7	0.5	-1.0	-1.2	-1.4	-1.4	-0.3	-1.3	0.9	-2.2	-1.2	0.8	0.1	-1.6	-1.9	-0.5	-1.8	1.3	-0.7
Taking other prescription medications	0.4	0.6	3.6	0.8	-0.1	-0.7	-0.9	-1.2	-1.2	-0.5	0.6	0.2	-0.8	-1.9	0.1	-0.5	-0.3	-0.1	-0.6	0.4	-0.3
Heart attack	0.4	0.5	2.2	-0.9	0.8	0.2	0.0	-0.1	-0.0	0.4	-0.6	-0.6	-0.1	-0.2	-1.2	-0.2	1.0	0.3	0.8	-1.0	-1.5
Pain all over the body in last month	0.4	0.5	1.9	0.9	-0.7	-0.6	-0.7	-0.8	-0.6	-0.7	1.0	0.0	-0.7	0.2	1.4	-0.8	-0.1	0.4	-0.3	0.8	0.2
Neuroticism score	0.4	0.8	2.3	-1.5	1.1	1.0	0.9	0.7	0.7	1.0	-1.0	0.9	0.9	0.8	-1.2	0.5	-0.8	-0.3	0.6	0.1	-1.2
Weight	0.4	1.8	6.9	-0.2	-0.9	-1.4	-1.5	-1.6	-0.0	-1.5	0.9	-2.6	-1.3	0.5	-0.5	-1.8	-1.7	-0.3	-1.5	1.2	-1.3
Trunk fat-free mass	0.4	2.4	5.9	0.3	-1.3	-2.0	-2.0	-2.2	-1.1	-2.0	1.6	-2.4	-1.9	-0.5	0.0	-2.0	-1.3	-0.8	-2.0	1.0	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	2.1	-1.3	0.3	0.5	0.3	0.3	-0.4	0.4	-0.6	0.5	0.5	0.6	-1.4	0.3	-1.5	-1.2	0.5	-0.4	-0.5
Trunk predicted mass	0.4	2.3	5.7	0.3	-1.3	-2.0	-2.0	-2.1	-1.1	-2.0	1.6	-2.4	-1.9	-0.5	0.1	-1.9	-1.3	-0.9	-2.0	0.9	-0.2
Headache pain in last month	0.4	0.6	4.3	0.7	-0.5	0.1	-0.2	-0.2	-0.9	-0.0	0.2	-0.4	0.0	-1.0	0.8	-0.3	-2.1	0.5	0.2	1.7	-0.9
Gout (self-reported)	0.4	0.6	1.4	0.4	-0.7	-0.8	-0.7	-0.6	-0.5	-0.9	0.7	-1.2	-0.7	-1.1	0.1	-1.2	-0.3	0.4	-0.4	1.2	-1.1
Forced vital capacity (FVC), Best measure	0.4	1.4	8.8	1.3	-1.2	-1.0	-1.0	-0.9	-3.0	-1.0	1.1	-1.1	-0.9	1.0	0.7	-0.3	0.2	-1.0	-0.8	-0.3	1.7
Leg fat mass (right)	0.4	1.4	6.0	-0.5	-0.3	-0.7	-0.9	-1.1	0.9	-0.9	0.4	-2.4	-0.7	0.4	-0.8	-1.4	-2.1	-0.1	-1.0	1.5	-1.9
Alcohol intake frequency.	0.4	1.0	5.0	-0.6	-0.7	-1.0	-1.2	-1.4	-0.5	-1.0	0.7	-2.2	-1.1	0.6	-0.5	-1.1	-0.8	0.1	-0.9	0.1	-1.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.6	0.9	-0.4	-0.3	-0.5	-0.4	-0.1	-0.3	0.4	0.3	-0.4	-1.0	0.7	-0.0	-1.6	-0.8	-1.2	0.6	0.8
Eye problems/disorders: Cataract	0.4	0.4	2.2	0.7	-0.1	-0.1	-0.1	-0.1	0.1	-0.1	0.4	0.7	-0.1	-1.2	0.5	-0.6	0.3	1.5	0.8	0.9	-0.9
Osteoporosis (self-reported)	0.4	0.5	1.2	-0.3	0.8	0.8	0.9	0.5	1.1	1.0	-0.5	1.0	0.8	1.0	-0.1	0.8	-0.5	0.8	0.2	0.4	-0.6
Medication: Aspirin	0.4	0.6	2.8	-0.4	-0.7	-0.6	-0.7	-0.6	-0.5	-0.6	0.1	-1.7	-0.7	-0.9	-0.6	-0.5	-0.3	-1.0	-1.2	-0.6	0.6
Guilty feelings	0.4	0.7	6.0	-1.0	0.6	0.5	0.5	0.4	0.5	0.5	-0.5	0.3	0.3	0.5	-1.0	-0.3	-1.1	-0.5	0.3	0.6	-2.4
Number of operations (self-reported)	0.4	0.6	2.5	-0.3	0.6	0.7	0.7	0.9	0.6	0.5	-0.3	0.5	0.8	1.5	-0.5	0.4	-1.4	0.1	0.6	0.4	-1.6
Average weekly beer plus cider intake	0.4	0.5	3.1	-1.0	0.5	0.5	0.8	0.7	1.8	0.4	-0.2	-0.0	0.6	0.2	-0.9	0.1	-0.5	0.1	0.6	0.3	-1.3
Diastolic blood pressure, automated reading	0.4	1.2	3.2	0.8	-1.3	-1.3	-1.1	-1.0	-0.5	-1.4	1.1	-1.4	-1.1	-1.8	0.8	-1.2	-0.9	-0.3	-1.3	0.8	0.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.2	-0.8	0.7	0.1	0.0	-0.1	0.2	0.3	-0.5	-0.6	-0.1	-0.2	-1.1	-0.2	1.2	0.4	0.9	-1.0	-1.5
Major Depression (MDD)	0.3	0.4	2.9	-0.4	0.5	0.3	0.6	0.6	0.3	0.1	-0.2	-0.1	0.4	-0.1	-0.2	-0.0	0.5	1.3	1.0	0.1	-1.7
Reaction Time	0.3	0.6	3.0	-1.7	-0.4	0.1	0.3	0.3	1.5	-0.2	-0.1	-0.4	0.4	-0.5	-1.5	0.1	0.4	0.5	1.1	-1.0	-0.7
Lung FVC	0.3	1.4	5.7	0.2	1.2	1.3	1.3	1.2	-1.5	1.1	-0.6	-0.1	1.4	2.4	-0.2	0.9	0.3	1.4	1.8	0.7	-1.1
Average weekly spirits intake	0.3	0.4	1.9	-1.3	0.2	0.1	0.2	0.2	0.2	0.2	-0.4	0.3	0.1	0.6	-1.4	0.2	-1.1	-0.6	-0.6	-0.7	-0.3
Fed-up feelings	0.3	0.5	2.3	-0.5	-0.2	-0.3	-0.2	-0.3	0.7	-0.5	0.5	-1.0	-0.1	-0.3	-0.4	-0.6	-1.4	0.8	-0.3	1.2	-1.5
Hayfever, allergic rhinitis or eczema	0.3	0.7	6.5	-0.2	0.1	0.7	0.6	0.7	-0.3	0.7	-0.4	0.6	0.7	2.6	0.1	0.9	0.4	1.2	1.2	-0.1	-0.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.7	0.5	0.8	0.4	0.6	0.4	1.3	0.5	0.0	0.5	0.6	-0.3	0.8	0.5	0.2	0.2	-0.1	1.0	-0.3
Alcohol usually taken with meals	0.3	0.5	2.6	0.6	-0.2	-0.3	-0.5	-0.8	-1.4	-0.1	-0.0	0.3	-0.6	0.0	0.2	0.1	1.6	1.2	0.2	-0.9	0.7
Had other major operations	0.3	0.4	2.4	0.5	-0.0	-0.2	-0.0	-0.1	1.0	-0.1	0.2	-0.2	-0.1	0.8	0.8	-0.0	1.6	1.2	0.8	0.4	-0.4
Forced vital capacity (FVC)	0.3	1.2	5.8	1.7	-1.1	-0.7	-0.7	-0.6	-2.4	-0.7	0.9	-0.8	-0.6	0.5	1.4	-0.1	1.3	-0.0	-0.3	0.2	1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	4.9	-1.5	0.2	0.3	0.4	0.4	0.9	0.2	-0.7	0.6	0.4	0.1	-1.1	0.5	-2.2	-1.5	-0.7	-0.4	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	2.3	-0.7	0.7	0.4	0.4	0.3	0.3	0.2	-0.0	-0.4	0.5	0.1	-0.3	0.1	-1.5	0.4	0.5	1.1	-1.5
Depression (self-reported)	0.3	0.3	1.3	-0.5	0.5	0.5	0.4	0.2	0.9	0.7	-0.2	0.9	0.4	0.1	-0.4	0.4	0.6	1.2	0.6	-0.2	-0.7
Birth weight of first child	0.3	0.6	3.7	-0.0	0.3	0.5	0.3	0.3	0.1	0.4	-0.3	1.6	0.6	1.9	0.9	1.0	0.1	-0.5	0.3	0.1	0.9
Medication: Amlodipine	0.3	0.4	1.5	0.8	0.6	0.4	0.4	0.5	1.1	0.3	0.0	0.1	0.3	-1.1	1.1	0.4	0.1	-0.4	-0.3	-0.2	1.2
Body fat percentage	0.3	1.0	4.0	0.0	-0.5	-0.7	-0.9	-1.0	0.4	-0.8	0.4	-2.0	-0.7	1.0	-0.4	-1.2	-1.9	-0.4	-1.3	1.2	-1.1
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.6	-0.9	0.1	0.5	0.7	0.6	0.5	0.3	-0.5	-0.4	0.7	0.2	-0.2	0.5	0.3	0.7	1.2	-0.2	-0.6
Whole body fat mass	0.3	1.4	5.7	0.0	-0.5	-0.9	-1.1	-1.2	0.4	-1.1	0.6	-2.4	-1.0	0.9	-0.3	-1.4	-2.1	-0.4	-1.4	1.3	-1.0
Medication: Aspirin	0.3	0.4	2.0	-0.5	-0.5	-0.5	-0.4	-0.4	-0.3	-0.5	0.0	-1.4	-0.5	-0.8	-0.8	-0.3	0.1	-0.8	-0.7	-0.8	0.5
Whole body fat-free mass	0.3	1.4	5.1	-0.3	-0.8	-1.5	-1.4	-1.6	-0.5	-1.5	1.0	-2.3	-1.4	0.2	-0.5	-1.6	-1.2	-0.2	-1.2	0.8	-1.1
Arm fat mass (left)	0.3	1.0	4.5	-0.5	-0.1	-0.4	-0.6	-0.7	0.9	-0.6	0.1	-2.1	-0.4	1.0	-0.8	-1.0	-1.7	0.2	-0.7	1.3	-1.9
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.2	-0.2	0.5	0.5	0.7	0.8	0.9	0.4	-0.3	0.5	0.7	0.6	0.1	0.6	-0.3	1.1	0.7	0.4	-0.3
Basal metabolic rate	0.3	1.5	5.4	-0.3	-0.8	-1.4	-1.4	-1.5	-0.3	-1.5	1.0	-2.3	-1.3	0.3	-0.5	-1.6	-1.4	-0.2	-1.3	1.0	-1.2
Leg fat percentage (left)	0.3	1.0	4.9	-0.8	-0.1	-0.2	-0.3	-0.5	1.0	-0.3	0.0	-2.2	-0.2	0.7	-1.0	-1.1	-2.0	-0.3	-0.8	1.2	-1.7
Arm fat-free mass (left)	0.3	1.7	6.0	-0.4	-0.7	-1.5	-1.4	-1.7	-0.4	-1.5	1.0	-2.5	-1.4	-0.1	-0.6	-1.8	-1.4	-0.2	-1.4	1.1	-1.4
Pack years of smoking	0.3	0.4	1.3	-0.8	-0.2	-0.3	-0.6	-0.5	-0.1	-0.2	0.2	-1.0	-0.6	-1.0	-0.6	-0.9	0.0	-0.2	-0.5	0.1	-1.1
Leg fat mass (left)	0.3	1.1	4.7	-0.9	0.0	-0.3	-0.4	-0.6	1.1	-0.5	0.0	-2.2	-0.3	0.8	-1.1	-1.1	-2.0	0.1	-0.6	1.2	-2.0
Arm predicted mass (left)	0.3	1.4	5.3	-0.5	-0.6	-1.4	-1.4	-1.6	-0.2	-1.4	0.8	-2.3	-1.3	-0.1	-0.7	-1.6	-1.1	-0.2	-1.3	0.9	-1.3
Neuroticism (Nagel 2018)	0.2	0.4	1.4	-1.0	0.1	-0.0	0.0	-0.2	0.3	0.1	-0.2	0.4	-0.2	-0.3	-1.1	-0.5	-1.2	-0.9	-0.6	0.1	-1.0
Blood Red Count	0.2	2.0	6.1	1.0	-1.8	-1.6	-1.2	-0.9	0.3	-2.1	1.9	-2.3	-1.0	-0.5	1.4	-1.5	-0.7	1.2	-0.2	2.5	-0.8
Neuroticism	0.2	0.5	3.4	-1.1	0.6	0.4	0.3	0.1	0.5	0.4	-0.3	0.7	0.3	-0.2	-0.6	-0.2	-1.0	0.2	0.3	0.8	-1.8
Hair Pigment	0.2	4.6	26.6	-3.1	1.0	1.1	0.7	0.1	-0.4	1.2	-1.8	5.2	1.1	0.0	-3.2	1.2	-2.5	-3.5	-0.6	-2.5	-0.5
Tanning	0.2	1.9	5.4	-0.8	1.2	1.4	1.7	1.3	2.3	1.6	-0.9	-1.3	1.4	1.2	-0.7	0.7	0.4	1.7	1.6	1.3	-1.9
Medication for hormone replacement therapy	0.2	0.2	1.1	0.0	-0.2	-0.3	0.1	0.2	0.0	-0.5	0.5	-0.4	0.1	-1.1	0.1	-0.4	0.2	0.8	0.6	0.7	-0.7
Leg fat-free mass (left)	0.2	1.0	4.0	-0.6	-0.4	-0.9	-0.8	-0.9	0.2	-1.0	0.6	-2.0	-0.7	0.7	-0.7	-1.1	-1.4	0.5	-0.5	0.9	-1.8
Supplements: Glucosamine	0.2	0.3	1.9	0.8	0.1	0.0	-0.2	-0.3	-0.4	0.1	-0.0	-0.2	-0.1	-0.8	0.3	0.2	1.4	0.4	0.5	-0.5	0.8
Leg predicted mass (left)	0.2	1.0	3.8	-0.6	-0.4	-0.9	-0.8	-0.9	0.3	-1.0	0.5	-2.0	-0.7	0.7	-0.7	-1.1	-1.4	0.5	-0.5	1.0	-1.9
Waist circumference	0.2	0.7	3.1	-0.6	0.2	-0.3	-0.4	-0.6	1.5	-0.4	-0.1	-1.7	-0.2	0.5	-0.7	-0.6	-1.7	-0.2	-0.9	0.9	-1.1
Nervous feelings	0.2	0.3	1.5	-1.1	-0.0	0.3	0.5	0.4	-0.7	0.4	-0.3	1.2	0.3	0.5	-0.5	0.5	0.0	0.2	0.4	-0.8	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.8	0.2	0.4	0.2	0.3	-0.0	0.9	0.3	0.0	0.1	0.3	0.2	0.5	0.1	-0.2	1.3	0.6	1.0	-0.9
Arm fat percentage (right)	0.2	0.8	3.4	-0.5	0.1	-0.1	-0.4	-0.4	1.1	-0.2	-0.1	-1.9	-0.1	0.9	-0.9	-0.7	-1.6	0.1	-0.7	1.1	-1.6
Hip circumference	0.2	0.9	4.7	-1.3	0.5	0.1	-0.2	-0.3	0.2	-0.1	-0.4	-1.1	0.0	1.3	-1.5	-0.6	-1.6	-0.2	-0.3	0.7	-2.2
Worrier / anxious feelings	0.2	0.4	1.8	0.6	-0.8	-0.4	-0.3	-0.1	0.2	-0.5	0.4	-1.1	-0.4	0.5	0.7	-0.6	-1.3	-0.1	-0.3	1.3	-0.3
Arm fat mass (right)	0.2	0.9	4.3	-0.7	-0.0	-0.3	-0.6	-0.7	1.0	-0.5	0.1	-2.1	-0.4	0.9	-1.0	-0.9	-1.4	0.3	-0.7	1.0	-1.7
Arm fat-free mass (right)	0.2	1.0	3.0	-0.5	-0.3	-1.1	-1.0	-1.2	-0.1	-1.0	0.7	-1.7	-0.9	0.5	-0.5	-1.3	-1.3	0.1	-0.7	1.0	-1.6
Exposure to tobacco smoke outside home	0.2	0.2	1.3	-1.1	0.1	0.2	0.1	0.1	0.1	0.1	-0.4	-0.1	0.2	0.5	-1.0	-0.1	-0.7	-0.8	0.0	-0.4	-0.1
Arm predicted mass (right)	0.2	1.1	3.5	-0.4	-0.5	-1.2	-1.1	-1.3	-0.1	-1.2	0.8	-1.9	-1.1	0.3	-0.6	-1.4	-1.3	0.1	-0.8	1.0	-1.6
Arm fat percentage (left)	0.2	0.8	3.5	-0.6	0.3	0.2	-0.0	-0.1	1.3	0.0	-0.3	-1.5	0.2	1.3	-0.8	-0.4	-1.7	0.2	-0.3	1.1	-1.9
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.1	0.1	1.0	0.4	0.4	0.5	0.9	0.3	-0.3	0.2	0.4	-0.2	-0.0	0.2	-1.0	-0.5	0.3	0.6	-0.6
Long-standing illness, disability or infirmity	0.2	0.3	1.3	-0.9	0.1	0.1	0.2	-0.0	0.5	-0.0	-0.2	-0.3	0.1	-0.6	-1.0	0.0	-0.4	0.5	0.2	-0.4	-1.2
Ever had bowel cancer screening	0.2	0.2	1.0	-0.1	-0.3	0.0	-0.1	-0.3	-1.0	0.0	-0.2	-0.0	0.1	0.8	-0.9	-0.0	0.4	0.7	0.6	0.0	-0.6
Mineral and other dietary supplements	0.2	0.3	2.1	-0.0	-0.4	-0.2	-0.5	-0.4	-0.7	-0.2	-0.1	-0.5	-0.4	0.5	-0.1	-0.1	-0.6	-1.4	-1.1	-0.3	0.5
Breast cancer (self-reported)	0.2	0.2	0.8	0.3	-0.0	-0.6	-0.4	-0.6	-0.1	-0.6	0.5	-0.8	-0.4	0.9	0.0	-0.3	0.5	0.1	-0.4	-0.1	0.2
Whole body water mass	0.2	1.3	4.6	-0.4	-0.6	-1.4	-1.3	-1.5	-0.4	-1.4	0.9	-2.1	-1.2	0.1	-0.6	-1.5	-1.3	-0.2	-1.2	0.8	-1.2
Ever taken oral contraceptive pill	0.2	0.2	1.0	0.4	-0.2	0.2	0.4	0.6	1.0	0.2	0.0	-0.0	0.4	0.4	0.4	0.3	0.1	0.9	0.5	0.5	-0.5
Irritability	0.2	0.4	4.4	0.1	0.2	-0.0	0.3	0.5	0.2	-0.2	0.2	-0.6	0.2	-2.1	0.5	-0.2	-0.7	-0.4	-0.3	0.6	0.2
Ever depressed for a whole week	0.2	0.2	0.9	-0.6	-0.5	-0.4	-0.3	-0.6	0.9	-0.2	0.3	0.0	-0.4	0.6	-0.4	-0.7	0.3	-0.6	-0.2	-0.2	-0.6
Alcohol drinker status: Previous	0.2	0.3	2.1	0.3	0.2	0.1	-0.1	-0.3	0.5	0.1	0.0	-0.5	-0.0	-0.3	0.7	-0.3	0.3	0.5	-0.0	1.0	-1.4
Worry (Nagel 2018)	0.1	0.1	0.5	-0.5	-0.4	-0.0	-0.2	-0.2	-0.4	0.1	-0.1	0.6	-0.2	0.4	-0.2	-0.1	0.1	-0.6	-0.3	-0.7	0.6
HDL Cholesterol	0.1	0.2	1.5	0.2	-0.3	-0.1	-0.2	-0.1	0.4	-0.0	-0.1	-0.4	-0.2	-0.3	-0.1	0.2	-0.3	-0.9	-0.8	-0.6	1.2
Triglycerides	0.1	0.2	1.4	0.0	0.4	0.0	-0.0	0.1	0.2	0.1	0.1	0.3	-0.0	-0.2	-0.1	-0.5	-1.2	-0.1	-0.0	0.6	-1.1
Heel T-Score	0.1	1.0	2.9	1.0	-1.3	-0.6	-1.1	-1.3	-0.8	-0.5	0.3	-0.7	-0.9	1.7	0.8	-0.4	-1.1	-0.8	-1.5	0.5	1.1
Hand grip strength (left)	0.1	0.2	0.9	0.5	-0.5	-0.3	-0.4	-0.0	-0.1	-0.4	0.4	0.1	-0.4	0.7	0.7	-0.2	-0.6	-0.9	-0.6	0.2	0.7
Sensitivity / hurt feelings	0.1	0.2	0.9	-0.5	0.2	0.4	0.2	0.2	0.3	0.5	-0.5	0.6	0.3	0.1	-0.8	0.6	-0.3	-0.9	0.4	-0.5	0.8
Pack years adult smoking proportion	0.1	0.2	1.4	-1.0	0.2	0.2	-0.0	0.1	0.1	0.3	-0.2	-0.6	-0.1	-0.6	-0.7	-0.4	0.0	-0.3	-0.1	0.1	-1.2
Hand grip strength (right)	0.1	0.3	1.4	0.7	-0.5	-0.2	-0.2	0.1	-0.1	-0.3	0.4	-0.0	-0.2	0.5	0.9	-0.2	-1.2	-0.5	0.1	1.0	-0.4
Allergy	0.1	0.2	1.2	-0.0	0.6	0.0	0.0	-0.1	0.4	0.0	-0.2	-0.5	-0.1	-1.1	-0.6	-0.2	0.4	-0.8	-0.3	-0.7	0.5
Illnesses of siblings	0.1	0.2	1.2	0.3	0.0	0.4	0.5	0.6	-0.0	0.5	-0.3	1.1	0.4	0.1	0.1	0.4	0.5	0.2	0.4	-0.0	-0.1
Alcohol intake versus 10 years previously	0.1	0.2	0.7	-0.8	0.6	0.1	-0.0	-0.2	-0.2	0.4	-0.3	-0.4	0.0	-0.3	-0.5	0.3	0.5	0.3	-0.3	-0.7	-0.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.6	0.2	-0.6	-0.0	-0.3	-0.3	-0.2	0.1	-0.2	0.1	-0.2	-0.8	0.4	0.1	0.0	0.3	-0.6	-0.1	-0.2
Worry too long after embarrassment	0.1	0.2	1.4	-0.2	-0.2	0.0	-0.2	-0.2	0.2	0.0	0.0	0.5	-0.2	1.0	-0.0	-0.0	-0.4	-1.2	-0.4	-0.3	0.4
Leg fat-free mass (right)	0.1	0.6	2.6	-0.8	0.0	-0.5	-0.4	-0.4	0.2	-0.5	0.1	-1.5	-0.3	1.2	-0.9	-0.6	-0.9	0.6	-0.1	0.4	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	2.0	0.2	0.2	0.1	-0.0	-0.1	-0.5	0.1	0.0	-1.0	0.1	1.4	-0.2	-0.0	-0.1	-0.8	0.1	0.2	-0.2
Leg predicted mass (right)	0.1	0.6	2.5	-0.8	-0.0	-0.5	-0.4	-0.5	0.2	-0.6	0.1	-1.6	-0.3	1.2	-0.9	-0.6	-0.9	0.6	-0.1	0.5	-1.6
Risk taking	0.1	0.2	1.9	-0.6	0.2	-0.1	-0.0	-0.2	-0.3	-0.0	-0.1	-0.1	-0.1	1.4	-0.2	-0.3	-0.3	-0.7	-0.3	-0.0	0.0
Ever had prostate specific antigen (PSA) test	0.1	0.1	1.1	0.4	-0.2	-0.1	0.0	0.1	0.3	0.0	0.1	0.3	-0.0	0.3	0.1	-0.2	1.1	0.8	0.6	0.3	-0.1
Fractured/broken bones in last 5 years	0.1	0.1	0.6	0.4	0.2	-0.1	-0.0	-0.1	0.6	-0.0	0.1	-0.7	-0.1	0.3	0.3	-0.3	-0.4	-0.3	0.2	0.8	-0.4

Hub : Genes

NUCB2

Models

Trait associations