Best TWAS P=1.06e-12 · Best GWAS P=7.24e-28 conditioned to 1.87e-16
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | APLNR | 0.07 | 0.01 | enet | 29 | 0.04 | 1.6e-05 | -5.62 | -5.9 | 3.7e-09 | -0.33 | 0.41 | 0.02 | TRUE |
2 | GTEx | Artery Tibial | MED19 | 0.22 | 0.12 | enet | 37 | 0.16 | 6.6e-13 | -2.82 | -6.8 | 8.9e-12 | -0.20 | 1.00 | 0.00 | FALSE |
3 | GTEx | Colon Transverse | MED19 | 0.10 | 0.00 | enet | 28 | 0.08 | 1.4e-04 | -2.82 | -5.7 | 9.2e-09 | 0.03 | 0.29 | 0.04 | FALSE |
4 | GTEx | Esophagus Mucosa | MED19 | 0.14 | 0.07 | lasso | 4 | 0.11 | 5.9e-08 | 6.77 | -6.4 | 1.4e-10 | 0.03 | 1.00 | 0.00 | FALSE |
5 | GTEx | Lung | MED19 | 0.12 | 0.00 | enet | 12 | 0.06 | 2.9e-05 | -2.82 | -6.1 | 1.2e-09 | 0.00 | 0.60 | 0.02 | FALSE |
6 | GTEx | Nerve Tibial | MED19 | 0.12 | 0.00 | enet | 25 | 0.02 | 2.1e-02 | -2.76 | -5.4 | 7.4e-08 | 0.04 | 0.71 | 0.02 | FALSE |
7 | GTEx | Skin Not Sun Exposed Suprapubic | MED19 | 0.12 | 0.05 | enet | 31 | 0.05 | 7.5e-04 | 4.83 | -5.9 | 3.5e-09 | 0.08 | 0.57 | 0.02 | FALSE |
8 | GTEx | Skin Sun Exposed Lower leg | MED19 | 0.15 | 0.11 | lasso | 7 | 0.09 | 1.3e-07 | 4.87 | -5.6 | 2.5e-08 | 0.11 | 1.00 | 0.00 | FALSE |
9 | GTEx | Thyroid | MED19 | 0.11 | 0.02 | lasso | 12 | 0.07 | 3.2e-06 | 6.81 | -7.1 | 1.1e-12 | 0.00 | 0.91 | 0.00 | TRUE |
10 | GTEx | Vagina | MED19 | 0.26 | 0.03 | lasso | 10 | 0.06 | 1.5e-02 | -3.25 | -5.3 | 9.8e-08 | 0.02 | 0.12 | 0.09 | FALSE |
11 | ROSMAP | Brain Pre-frontal Cortex | SLC43A3 | 0.04 | 0.01 | enet | 16 | 0.02 | 2.7e-03 | 1.12 | -5.8 | 7.9e-09 | -0.50 | 0.14 | 0.34 | FALSE |
12 | ROSMAP | Brain Pre-frontal Cortex | ZDHHC5 | 0.05 | 0.02 | blup | 401 | 0.03 | 2.0e-04 | 3.96 | -5.2 | 1.5e-07 | 0.06 | 0.38 | 0.02 | FALSE |
13 | YFS | Blood | MED19 | 0.47 | 0.18 | enet | 73 | 0.28 | 7.1e-93 | -2.71 | -5.3 | 9.4e-08 | 0.00 | 1.00 | 0.00 | FALSE |
14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LRRC55 | 0.10 | 0.01 | blup | 62 | 0.04 | 1.2e-05 | 0.04 | 6.0 | 1.7e-09 | 0.26 | 0.01 | 0.20 | TRUE |