Hub : Genes

ZDHHC5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Lung 0.0952 0.0376 1.2e-03 -0.002 NA 0.003 NA 0.000 4.7e-01 NA 1.7e-01 NA 3.1e-01
2 GTEx Skin Sun Exposed Lower leg 0.0510 0.0210 6.4e-04 0.029 NA 0.020 NA 0.022 1.7e-03 NA 8.6e-03 NA 6.2e-03
3 GTEx Whole Blood 0.0600 0.0300 4.8e-03 0.002 NA -0.002 NA -0.002 2.2e-01 NA 4.8e-01 NA 5.7e-01
4 ROSMAP Brain Pre-frontal Cortex 0.0488 0.0222 1.4e-03 0.019 0.027 0.015 0.026 0.013 1.5e-03 2.0e-04 4.1e-03 2.1e-04 6.4e-03
5 YFS Blood 0.0586 0.0144 0.0e+00 0.074 0.065 0.073 0.069 0.072 3.2e-23 2.6e-20 1.2e-22 1.2e-21 2.2e-22
6 TCGA Breast Invasive Carcinoma 0.0159 0.0103 2.0e-03 0.006 0.012 0.007 NA 0.010 2.0e-02 1.5e-03 1.4e-02 NA 2.9e-03
7 TCGA Colon Adenocarcinoma 0.1050 0.0710 1.3e-03 0.045 0.042 0.028 NA 0.038 1.3e-03 1.8e-03 9.3e-03 NA 2.9e-03
8 TCGA Prostate Adenocarcinoma 0.0990 0.0453 2.0e-09 0.113 0.096 0.100 NA 0.107 7.7e-12 2.9e-10 1.2e-10 NA 2.9e-11

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.6 1.0 2.7 1.6 -0.1 -0.2 0.1 0.2 -1.3 -1.3 -1.3
Bipolar Disorder or Schizophrenia 2.9 7.1 12.5 3.2 3.2 3.5 -2.8 3.5 -0.7 -1.1 -1.6
Depressed Affect (Nagel 2018) 4.5 9.5 18.4 3.0 3.8 3.1 -4.3 4.1 -0.9 -1.8 -2.0
Depression (Nagel 2018) 8.2 12.4 27.0 2.4 5.2 3.6 -4.8 5.2 -0.0 -1.1 -1.4
Intelligence (Savage-Jansen 2018) 2.4 7.4 19.1 -1.9 -4.4 -2.7 3.0 -4.3 0.1 0.6 1.0
Neuroticism (Nagel 2018) 9.7 22.9 44.9 4.9 6.3 4.2 -6.6 6.7 -0.7 -2.4 -2.5
Schizophrenia (2018) 4.8 10.0 22.6 2.7 4.2 4.8 -3.6 4.4 0.2 -0.4 -1.0
Schizophrenia vs Biploar Disorder 4.6 6.0 13.8 0.6 3.7 1.3 -2.6 2.6 2.9 2.4 2.1
Worry (Nagel 2018) 4.5 9.5 19.1 4.3 3.7 2.8 -3.5 4.4 -0.5 -1.5 -1.6
Alzheimer’s Disease (in mother) 0.3 0.4 1.0 -0.7 0.7 -0.5 -1.0 0.4 -0.1 -0.5 -0.5
Alzheimer’s Disease (in father) 0.4 0.4 1.1 0.4 0.8 1.0 -0.7 0.9 -0.2 0.1 -0.2
Alzheimer’s Disease (including proxy) 0.5 0.7 2.2 -0.1 1.5 0.8 -1.0 1.2 0.1 -0.2 -0.4
Crohns Disease (2017) 0.6 1.3 4.9 2.2 -0.8 1.7 0.8 -0.9 0.3 0.0 0.4
Irritable Bowel Disease (IBD) 0.8 1.8 9.4 3.1 -0.9 1.6 0.9 -0.9 0.2 0.0 0.4
Ulcerative Colitis (UC) 0.5 1.0 6.2 2.5 -0.3 1.2 0.4 -0.2 0.1 -0.1 0.3
Major Depression (MDD) 8.9 10.8 25.7 2.1 5.1 4.0 -4.0 4.5 1.9 0.3 0.3
Reaction Time 0.7 1.3 4.2 0.9 2.0 -0.5 -0.7 1.9 0.6 0.8 0.3
Verbal and Numeric Reasoning (VNR) 2.6 6.3 16.4 -2.0 -4.1 -2.8 2.3 -4.0 0.3 0.7 1.1
Breast Cancer 1.9 4.6 10.7 -0.6 -3.3 -3.2 1.6 -2.4 -2.0 -1.2 -1.2
Ovarian Cancer 0.8 1.1 2.1 -0.6 -1.2 -0.8 1.3 -1.5 0.3 1.1 1.0
Prostate Cancer 2.4 3.4 7.9 -2.0 -2.2 -2.3 1.5 -2.8 0.3 1.0 1.2
Age at First Birth 1.0 1.5 3.6 -0.1 0.4 -0.7 -0.7 1.1 -1.8 -1.7 -1.9
Bipolar Disorder (2011) 1.4 1.3 6.8 2.6 0.6 0.6 -0.1 1.2 -0.8 -0.7 -0.8
Body Mass Index (BMI) (2010) 1.4 1.9 4.8 1.4 1.7 1.1 -0.9 2.2 -0.7 -1.1 -1.5
Coronary Artery Disease (CAD) 3.0 3.6 10.7 0.5 0.7 0.4 0.4 -0.1 3.3 2.9 3.0
Crohns Disease (2012) 0.7 1.1 2.8 0.9 -1.7 0.0 1.6 -1.6 0.2 0.1 0.3
Mean Putamen Volume 1.4 1.6 5.8 -0.3 -1.5 -1.0 2.4 -1.6 0.4 0.8 0.8
Fasting Glucose 1.0 1.2 3.2 -0.1 -0.5 -0.7 -0.1 0.2 -1.6 -1.6 -1.8
HbA1C 0.9 1.0 2.5 -0.8 -0.3 -1.6 0.0 -0.6 -1.0 -1.5 -1.1
HDL Cholesterol 0.7 1.1 2.7 0.1 1.2 -0.7 -1.1 1.6 -1.0 -1.0 -1.2
LDL Cholesterol 0.8 1.2 3.0 -1.0 -0.3 -0.3 0.4 -0.6 1.4 1.7 1.7
Lupus 0.8 1.1 3.5 -0.3 0.7 0.3 -0.3 -0.1 1.9 1.4 1.7
Neuroticism (2016) 3.5 5.1 12.6 1.2 3.0 1.7 -3.6 3.4 -0.4 -1.2 -1.2
Primary Biliary Cirrhosis 1.6 2.3 5.3 0.4 1.4 0.7 -0.6 0.3 2.3 2.1 2.2
Rheumatoid Arthritis 0.2 0.3 1.9 -0.8 -0.1 1.4 0.3 0.1 0.3 0.1 0.2
Schizophrenia (2014) 4.8 10.5 21.6 2.6 4.6 4.2 -4.0 4.6 0.4 -0.4 -0.8
Triglycerides 1.2 2.0 5.2 0.7 0.8 1.9 0.5 0.6 2.3 1.7 1.5
Type 2 Diabetes (T2D) (2012) 0.5 0.5 2.4 0.4 -0.2 -1.0 1.6 0.1 -0.6 -0.2 -0.4
Ulcerative Colitis 0.7 1.0 2.7 0.9 -1.6 0.4 1.5 -1.2 -0.7 -0.6 -0.2
Blood Eosinophil Count 1.2 9.4 27.6 0.0 4.5 1.7 -5.2 3.3 -1.3 -2.1 -2.8
Blood Platelet Count 4.1 47.7 96.2 9.5 9.8 6.6 -8.1 8.3 -0.4 -2.8 -2.8
Blood Red Count 1.9 18.8 36.2 3.8 4.9 4.2 -4.3 6.0 -2.6 -3.8 -4.2
Blood White Count 0.4 2.8 5.5 2.3 0.9 1.4 -0.9 1.9 -1.5 -1.8 -2.1
Heel T-Score 1.3 10.3 32.0 -0.1 5.7 2.9 -3.5 4.7 2.5 0.9 0.8
BMI 0.7 3.8 11.3 2.4 2.7 2.0 -1.3 3.4 0.1 -0.6 -0.7
Height 1.6 31.4 64.0 -3.8 -5.3 -4.8 1.8 -2.7 -8.0 -7.5 -7.3
Waist Hip Ratio (WHR) 0.7 3.0 7.3 0.1 0.1 -0.5 -1.0 1.2 -2.7 -2.7 -2.6
Systolic Blood Pressure 5.9 29.4 52.0 -1.2 -6.7 -2.2 6.6 -7.2 3.9 5.8 6.2
Smoking Status 0.9 2.1 5.5 -1.2 2.1 -0.2 -2.2 2.3 -0.1 -0.5 -0.5
Allergy or Eczema 0.1 0.2 0.6 -0.4 0.4 0.8 -0.4 0.4 -0.3 -0.1 -0.0
Cardiovascular Disease 1.3 4.1 9.3 1.6 0.3 2.4 0.6 0.1 2.8 2.7 3.0
Hypothyroidism (self reported) 1.7 3.9 9.5 0.4 -0.7 -0.5 0.7 -1.5 2.9 3.0 3.1
Respiratory disease 2.1 4.6 8.8 -0.6 1.8 1.3 -2.2 2.0 -2.4 -2.9 -3.0
Type 2 Diabetes (T2D) (2018) 0.4 0.8 2.2 0.4 -0.6 0.2 0.6 -0.5 1.0 1.4 1.5
Lung FEV1/FVC ratio 2.9 14.5 36.7 -1.8 -6.1 -3.7 6.0 -4.1 -2.5 -1.5 -1.4
Lung FVC 0.3 1.5 4.1 -0.7 -0.2 1.1 2.0 -0.6 1.7 1.1 1.2
Neuroticism 9.7 23.3 48.1 4.9 6.7 3.7 -6.7 6.9 -0.8 -2.0 -2.5
Chronotype (morning person) 2.9 6.7 19.7 -0.1 -4.4 -1.5 4.3 -3.2 -1.5 -0.8 -0.6
Hair Pigment 0.1 1.5 3.6 -1.2 0.5 -1.0 0.3 -0.2 1.9 1.4 1.9
Tanning 0.4 4.3 10.4 -0.5 -3.0 -2.7 3.2 -2.5 -0.3 0.6 0.7
Hand grip strength (left) 2.9 7.7 16.0 -3.5 -3.8 -4.0 3.0 -2.5 -1.7 -0.8 -0.8
Number of treatments/medications taken 0.4 0.8 2.5 0.7 0.6 1.6 -0.6 1.1 -0.5 -0.8 -0.7
Average weekly spirits intake 0.5 0.6 1.0 0.3 0.8 0.5 -0.8 0.7 -1.0 -0.9 -0.9
Sensitivity / hurt feelings 5.8 10.0 19.2 3.8 4.1 1.1 -4.1 4.4 -1.1 -2.3 -2.2
Frequency of depressed mood in last 2 weeks 7.0 9.8 23.7 2.2 4.9 3.0 -4.5 4.4 0.9 0.0 -0.2
Hearing difficulty/problems: Yes 3.2 4.8 11.5 3.0 2.6 2.9 -1.7 3.4 -0.1 -0.3 -0.6
Relative age of first facial hair 0.2 0.3 0.9 -0.8 -0.4 0.9 0.6 -0.4 0.1 -0.3 -0.5
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.3 1.1 0.8 1.0 -0.7 0.7 0.9 0.4 0.6
Ever used hormone-replacement therapy (HRT) 1.5 1.9 5.7 -0.8 1.1 1.4 -0.1 0.4 2.4 1.6 1.7
Ever had hysterectomy (womb removed) 1.8 2.0 4.4 -0.6 -1.8 0.0 1.4 -2.1 1.4 1.3 1.5
Systolic blood pressure, automated reading 4.6 13.3 22.4 -1.1 -4.3 -1.5 4.2 -4.7 2.9 4.2 4.4
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 1.5 -0.5 -1.2 -0.3 0.8 -1.1 0.1 0.3 0.3
Angina 1.1 1.4 3.8 -0.9 -1.9 -0.4 1.0 -1.8 0.5 0.9 1.0
Medication for hormone replacement therapy 0.6 0.7 3.8 -2.0 0.5 0.2 -0.0 0.4 0.5 0.6 0.6
Vitamin and mineral supplements 0.9 1.2 2.9 -1.2 -1.3 -1.4 1.7 -1.1 -0.3 0.6 0.2
Supplements: Zinc 0.5 0.5 2.7 -1.6 0.0 -0.7 -0.8 -0.1 -0.2 0.2 0.4
Medication: Co-codamol 1.8 2.1 5.0 2.2 1.7 1.9 -0.9 1.9 -0.2 -0.6 -0.4
Medication: Metformin 0.2 0.3 0.7 0.5 0.4 0.1 -0.6 0.6 0.4 0.8 0.8
Diabetes (father) 0.4 0.5 1.4 -0.0 -0.3 0.9 -0.2 -0.1 -1.0 -0.9 -1.2
Diabetes (mother) 0.4 0.5 1.6 0.3 -0.7 -0.4 -0.0 0.3 -0.9 -1.3 -1.0
Severe depression (siblings) 1.1 1.3 3.2 -0.6 0.9 -0.3 -1.8 0.8 -1.3 -1.3 -1.3
Pack years adult smoking proportion 3.3 5.0 10.9 2.1 3.3 2.8 -2.3 3.3 0.0 -0.5 -0.8
Impedance of leg (right) 0.1 0.5 1.2 -0.1 0.5 0.5 -0.8 0.5 -0.7 -0.8 -1.1
Leg fat-free mass (left) 0.4 2.2 6.0 -0.1 -1.2 -0.2 0.6 0.1 -2.1 -2.4 -2.3
Trunk fat percentage 2.5 10.0 23.5 3.3 4.1 4.1 -2.4 4.8 -0.2 -1.5 -1.8
Hand grip strength (right) 1.9 5.1 11.4 -2.2 -3.4 -2.2 3.3 -2.1 -1.6 -0.9 -1.0
Townsend deprivation index at recruitment 5.2 7.3 16.6 2.7 4.1 3.8 -2.6 3.5 1.3 0.3 0.1
Current tobacco smoking 2.2 3.7 10.0 0.1 2.7 1.9 -2.2 3.2 -0.4 -1.3 -1.3
Average weekly fortified wine intake 0.3 0.3 1.5 -0.9 -0.0 -1.2 0.0 -0.4 0.1 0.3 0.3
Maternal smoking around birth 0.3 0.5 1.3 0.8 0.2 1.1 -0.4 -0.2 0.7 0.8 0.8
Fed-up feelings 7.2 13.1 24.2 3.9 4.9 4.7 -4.4 4.8 0.6 -0.5 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 7.1 9.5 25.1 1.4 5.0 3.3 -3.9 4.7 0.4 -0.5 -0.8
Relative age voice broke 0.5 0.7 4.0 -2.0 0.1 0.4 -0.1 -0.4 0.7 0.6 0.6
Taking other prescription medications 1.3 2.0 3.5 0.9 1.4 1.0 -1.3 1.9 -1.1 -1.6 -1.7
Age when periods started (menarche) 1.6 3.9 10.2 0.7 -0.3 -0.9 0.1 0.8 -3.0 -3.2 -3.2
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.4 -0.4 -1.5 -0.5 1.4 -1.1 0.5 0.8 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 2.7 0.0 0.4 -0.8 -0.4 1.1 -1.1 -1.6 -1.6
Tinnitus: Yes, but not now, but have in the past 1.3 1.4 4.0 -0.1 -0.0 0.2 0.2 0.5 -1.8 -1.9 -2.0
Qualifications: CSEs or equivalent 3.2 4.2 12.1 1.9 3.1 2.4 -1.4 3.5 0.7 0.3 0.2
Serious illness, injury or assault to yourself 0.8 1.0 3.0 1.0 -0.2 0.6 -0.2 0.1 -1.3 -1.7 -1.4
High blood pressure 1.0 2.8 6.2 1.8 -0.3 2.5 0.7 0.2 1.9 2.0 2.2
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.8 -0.3 -0.5 -0.1 0.1 -0.3 -0.9 -0.6 -0.5
Multivitamins +/- minerals 0.4 0.6 1.6 0.4 1.0 1.2 -0.7 0.7 0.8 0.1 0.6
Stomach or abdominal pain in last month 0.6 0.8 3.0 1.7 0.5 1.1 -0.8 0.8 -0.3 -0.4 -0.4
Supplements: Glucosamine 1.3 1.7 3.3 -1.4 -1.8 -1.8 1.2 -1.4 -1.2 -0.5 -0.4
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.5 -0.4 0.1 -0.7 -0.3 0.6 -0.7 -0.2 -0.5
Medication: Atenolol 0.6 0.7 1.3 0.5 1.1 0.9 -1.0 1.0 0.7 0.9 0.7
Medication: Levothyroxine sodium 1.2 2.0 5.0 0.1 -0.2 1.1 0.1 -0.8 2.2 2.0 2.2
Sitting height 1.9 13.3 34.2 -3.8 -5.8 -3.5 3.5 -5.4 -1.9 -0.7 -0.7
Chronic bronchitis/emphysema (father) 1.6 1.8 4.7 -0.4 0.1 -0.1 -0.8 0.8 -2.2 -2.0 -2.1
High blood pressure (mother) 1.1 1.6 4.1 0.1 -2.0 -1.2 2.0 -1.5 0.2 0.7 0.6
Body mass index (BMI) 0.6 2.5 5.9 2.0 1.9 2.4 -0.7 2.4 0.7 -0.2 -0.1
Impedance of leg (left) 0.1 0.7 1.5 -0.1 0.7 0.6 -0.9 0.9 -0.8 -0.9 -1.2
Leg predicted mass (left) 0.4 2.1 5.8 -0.0 -1.2 -0.2 0.6 0.1 -2.1 -2.4 -2.3
Trunk fat mass 1.4 6.1 14.1 2.5 2.7 3.1 -1.6 3.8 -0.9 -2.0 -2.2
Waist circumference 0.7 2.7 5.4 1.7 0.5 1.0 -0.0 2.0 -1.8 -2.3 -2.3
Number of incorrect matches in round 0.2 0.4 0.9 0.7 0.3 -0.5 -0.8 0.0 0.6 0.8 0.9
Past tobacco smoking 0.4 0.8 1.9 1.4 -0.8 -0.1 1.3 -0.4 -0.9 -0.7 -0.9
Alcohol usually taken with meals 7.1 11.5 31.2 -1.4 -5.6 -3.5 4.9 -4.7 -0.8 0.2 0.0
Nervous feelings 0.8 1.6 5.4 2.3 1.2 1.3 -1.6 1.3 0.2 -0.1 0.2
Frequency of tenseness / restlessness in last 2 weeks 3.3 5.1 11.4 2.3 2.7 2.7 -3.4 2.6 -0.4 -0.9 -1.2
Hearing difficulty/problems with background noise 1.2 2.0 5.4 2.3 1.3 1.0 -0.2 1.5 1.6 1.3 1.1
Hair/balding pattern: Pattern 2 4.2 5.3 9.1 -1.4 -3.0 -2.4 2.4 -1.8 -2.8 -2.2 -2.1
Had menopause 1.1 1.4 3.4 -0.8 -0.2 0.4 -0.5 -1.3 1.9 1.4 1.8
Had other major operations 0.3 0.4 1.3 -1.1 -0.8 -1.0 0.5 -0.2 0.0 -0.4 -0.1
Forced vital capacity (FVC) 0.6 2.3 5.8 -1.3 -2.4 -0.2 2.0 -1.5 -1.1 -1.3 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 3.0 -0.6 1.2 -0.8 -0.9 1.7 -0.6 -1.1 -1.1
Ever unenthusiastic/disinterested for a whole week 2.1 2.6 7.0 1.2 2.6 0.5 -2.5 2.1 0.8 0.7 0.5
Qualifications: None of the above 4.0 8.5 20.4 1.7 4.5 3.6 -2.8 3.9 2.3 1.3 1.2
Financial difficulties in last 2 years 2.8 3.8 11.5 0.1 3.4 1.0 -2.5 2.7 1.4 1.1 0.8
Mouth/teeth dental problems 1.8 2.7 7.5 -0.7 -2.7 -2.1 1.7 -2.3 -1.0 -0.1 -0.0
Heart attack 0.3 0.4 0.9 -0.7 -0.3 -0.4 -0.6 -0.6 0.8 0.7 0.9
Allergy 1.1 2.6 5.5 -0.8 -0.7 -0.9 1.1 -1.2 2.3 2.3 2.3
Pain all over the body in last month 3.6 3.9 8.4 2.7 2.9 1.8 -2.2 2.7 0.6 -0.0 -0.0
Diabetes (self-reported) 0.6 0.9 1.9 -0.2 -1.4 -0.6 0.4 -1.1 0.6 1.2 1.4
Hayfever/allergic rhinitis (self-reported) 1.4 1.8 6.2 -2.5 -1.3 -1.2 1.5 -1.4 0.3 0.9 0.7
Medication: Ramipril 0.8 1.0 3.4 -0.4 -1.9 0.1 1.5 -1.3 -0.0 0.6 0.6
Medication: Simvastatin 0.9 1.3 2.8 0.8 -0.6 -0.5 1.6 -0.5 1.3 1.5 1.7
Fluid intelligence score 2.0 4.1 13.0 -0.6 -3.6 -2.3 1.7 -3.2 -0.1 0.5 0.7
Illnesses of siblings 1.6 2.2 6.6 0.0 -0.3 -0.5 0.1 0.6 -2.0 -2.5 -2.6
Neuroticism score 9.8 20.5 46.8 4.6 6.3 3.5 -5.8 6.8 -0.7 -2.0 -2.3
Weight 0.5 2.5 6.4 1.0 0.1 1.1 -0.0 1.5 -1.9 -2.5 -2.5
Impedance of arm (right) 2.5 11.9 25.3 2.7 4.4 2.6 -3.4 5.0 -2.1 -2.9 -3.4
Arm fat percentage (right) 2.8 11.0 27.5 3.4 4.4 4.1 -2.5 5.2 -0.2 -1.5 -1.8
Trunk fat-free mass 1.2 7.0 15.6 -2.1 -4.0 -2.3 2.5 -2.5 -2.8 -2.5 -2.3
Hip circumference 0.6 2.5 5.4 1.4 -0.6 1.1 1.0 1.1 -1.8 -2.3 -2.3
Time employed in main current job 0.2 0.2 0.7 0.8 -0.4 -0.2 0.5 0.1 0.6 0.3 0.4
Alcohol intake versus 10 years previously 0.5 0.7 1.6 -0.1 1.3 0.2 -0.9 1.1 1.2 0.5 0.6
Father’s age at death 1.8 2.4 4.2 -2.0 -0.9 -1.9 0.2 -0.5 -2.0 -1.6 -1.8
Worrier / anxious feelings 8.1 15.3 33.4 5.0 5.2 3.8 -4.2 5.8 -0.1 -1.5 -1.6
Frequency of tiredness / lethargy in last 2 weeks 7.8 12.6 26.9 1.8 5.2 4.9 -4.5 4.9 1.4 -0.5 -0.5
Falls in the last year 1.0 1.4 2.5 0.6 1.2 1.4 -0.9 1.3 -0.8 -1.6 -1.4
Hair/balding pattern: Pattern 3 0.9 1.4 5.7 -2.4 -1.4 -0.9 1.2 -0.9 -0.4 -0.1 -0.0
Number of live births 0.1 0.1 0.4 0.7 0.4 0.6 -0.3 0.3 0.2 -0.1 0.0
Forced expiratory volume in 1-second (FEV1) 2.0 6.9 18.5 -2.3 -4.3 -1.3 4.1 -3.1 -1.2 -1.0 -0.8
Pulse rate 0.8 1.4 2.9 0.0 0.5 -1.2 -1.2 0.7 -1.6 -1.7 -1.6
Happiness 2.9 3.5 6.8 0.3 2.2 2.5 -1.1 1.0 2.6 2.2 1.9
Noisy workplace 0.7 0.9 1.9 -1.4 -0.7 -0.9 1.4 -1.0 0.0 0.7 0.5
Qualifications: A levels/AS levels or equivalent 2.1 4.5 10.1 -2.8 -3.2 -1.9 1.9 -3.2 -1.1 -0.3 -0.4
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 2.1 1.5 -1.0 -0.9 0.6 -0.7 -0.9 -0.6 -0.4
Mouth/teeth dental problems: Dentures 1.3 2.1 3.7 -1.0 1.7 1.6 -1.3 0.8 1.9 1.5 1.6
Asthma 1.7 3.4 6.2 -0.6 1.6 1.6 -1.8 1.6 -1.9 -2.5 -2.5
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 2.2 -0.3 0.9 0.8 -0.1 1.4 -1.1 -1.1 -1.5
Medication: Cholesterol lowering 0.6 0.9 2.3 0.8 -1.4 -1.0 1.5 -0.8 0.2 0.4 0.7
Depression (self-reported) 3.6 4.4 9.4 2.0 3.1 2.2 -2.6 3.0 0.8 -0.3 -0.3
Medication: Lansoprazole 1.2 1.4 5.2 0.7 1.1 2.3 -1.3 1.6 0.4 -0.3 -0.1
Prospective memory result 3.8 4.6 9.7 2.2 3.1 2.7 -2.8 2.4 0.9 0.5 0.3
Lung cancer (father) 1.0 1.2 3.7 0.0 1.5 0.4 -1.9 1.4 -0.5 -0.8 -0.9
Illnesses of mother 0.8 0.9 2.9 -0.0 0.9 1.7 -0.4 1.0 -0.6 -1.0 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.9 6.1 15.6 -2.4 -3.8 -1.6 4.0 -2.3 -1.5 -1.3 -1.2
Pulse wave Arterial Stiffness index 0.4 0.5 1.3 0.6 -1.1 -1.0 0.6 -0.6 -0.6 -0.4 -0.2
Impedance of arm (left) 2.2 10.4 20.5 2.5 4.0 2.6 -3.3 4.5 -2.0 -2.8 -3.2
Arm fat mass (right) 1.4 5.8 13.5 2.5 2.6 3.1 -1.6 3.7 -0.8 -1.8 -1.9
Trunk predicted mass 1.2 7.0 15.5 -2.1 -3.9 -2.3 2.5 -2.4 -2.7 -2.5 -2.2
Standing height 1.5 15.4 31.5 -2.3 -4.1 -3.0 1.5 -1.9 -5.6 -5.2 -5.2
Length of working week for main job 0.7 0.8 1.4 -1.1 -0.2 -0.6 -1.1 -0.1 -1.2 -0.9 -1.1
Exposure to tobacco smoke at home 1.7 1.9 3.9 0.9 2.0 1.1 -1.9 1.6 1.1 1.0 0.9
Breastfed as a baby 0.7 0.9 3.6 -1.9 -0.8 -1.5 0.5 -0.7 -0.3 -0.1 0.0
Tense / ‘highly strung’ 3.7 6.2 13.4 3.0 3.7 1.7 -3.2 3.6 0.2 -0.5 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 4.3 6.5 15.0 2.7 3.6 2.3 -3.1 3.9 -0.4 -0.9 -1.1
Hair/balding pattern: Pattern 4 2.3 5.5 13.8 1.1 0.2 1.5 -0.1 -1.3 3.7 3.4 3.7
Birth weight of first child 1.5 2.7 6.2 -0.7 -1.1 -1.9 0.3 -0.4 -2.4 -2.2 -2.5
Peak expiratory flow (PEF) 2.4 5.7 13.7 -1.7 -3.7 -1.0 3.6 -2.5 -1.8 -1.5 -1.6
Pulse wave reflection index 0.4 0.5 1.4 1.2 -0.5 0.9 0.5 -0.4 0.7 0.3 0.6
Ever highly irritable/argumentative for 2 days 0.9 1.1 2.6 1.6 0.4 0.4 1.0 1.6 -0.5 -1.0 -1.0
Loud music exposure frequency 1.1 1.2 1.9 0.4 1.2 1.2 -1.1 1.4 -0.9 -1.2 -1.2
Qualifications: O levels/GCSEs or equivalent 1.8 2.9 6.6 -1.5 -2.6 -2.3 1.1 -2.4 -1.2 -0.8 -0.6
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 3.1 0.8 -0.9 0.1 1.8 -0.4 0.0 0.0 -0.1
Blood clot in the leg (DVT) 1.3 1.7 5.3 2.3 1.6 0.8 -0.9 1.7 -0.2 -0.5 -1.0
Medication: Paracetamol 3.8 6.3 10.0 2.6 2.4 1.4 -1.8 3.2 -2.2 -3.0 -3.0
Headache pain in last month 6.1 10.4 18.6 2.2 3.6 2.4 -3.2 4.3 -2.2 -3.5 -3.7
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 2.5 -1.6 0.4 0.2 -0.4 -0.3 0.3 0.1 -0.0
Glaucoma (self-reported) 2.3 2.7 5.9 -1.4 -2.4 -2.2 2.1 -1.8 -1.0 -0.6 -0.3
Gout (self-reported) 0.4 0.6 1.8 0.3 -1.0 1.3 1.1 -0.1 -0.2 -0.6 -0.4
Hypothyroidism/myxoedema (self-reported) 2.0 3.8 9.0 -0.5 -0.9 -0.7 1.2 -1.7 2.8 2.9 3.0
Medication: Amlodipine 2.4 3.4 9.6 -0.7 -0.8 -0.2 0.7 -1.5 2.3 2.9 3.1
Medication: Ventolin 100micrograms inhaler 1.5 1.9 3.5 0.8 1.7 0.3 -1.9 1.5 -1.0 -1.4 -1.7
Birth weight 1.3 2.8 10.0 -1.0 -0.4 -3.2 -0.6 0.1 -2.0 -1.8 -1.8
Chronic bronchitis/emphysema (mother) 1.6 1.9 4.3 2.0 1.6 0.3 -2.1 1.9 -0.2 -0.4 -0.7
High blood pressure (siblings) 0.7 1.0 1.9 0.4 -1.1 -0.5 1.2 -1.1 0.5 1.4 1.4
Forced vital capacity (FVC), Best measure 0.6 2.1 4.1 -1.7 -1.9 -0.5 2.0 -0.9 -1.2 -1.4 -1.3
Body fat percentage 2.3 9.1 21.1 3.1 4.0 4.2 -2.3 4.6 0.1 -1.2 -1.4
Leg fat percentage (right) 1.1 4.0 10.1 1.9 2.6 3.2 -1.3 3.0 0.6 -0.5 -0.6
Arm fat-free mass (right) 0.8 4.2 11.9 -1.9 -3.5 -1.6 2.2 -2.5 -1.3 -1.2 -0.9
Exposure to tobacco smoke outside home 0.5 0.6 1.8 0.2 -1.3 -1.3 0.5 -0.7 -0.7 -0.3 -0.4
Comparative body size at age 10 1.6 4.4 13.5 3.7 1.8 2.3 -1.2 2.5 -0.8 -1.7 -1.4
Number of full brothers 2.6 3.3 5.8 -1.5 -1.6 -2.0 2.4 -2.0 0.9 1.9 1.8
Worry too long after embarrassment 10.1 16.9 40.7 2.8 6.1 3.1 -5.6 6.4 -0.4 -2.0 -2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 2.4 3.2 6.2 1.3 2.4 1.4 -2.4 2.5 -0.5 -1.4 -1.3
Wheeze or whistling in the chest in last year 1.2 2.2 3.8 -0.7 1.2 0.8 -1.7 1.3 -1.7 -1.9 -1.9
Number of children fathered 0.8 0.9 2.2 -1.4 -1.2 -0.4 0.9 -1.5 0.5 0.6 0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 2.3 1.5 0.6 0.2 -0.7 0.7 -0.1 -0.4 -0.4
Age at first live birth 0.7 1.3 2.1 -0.3 -1.5 -1.1 0.1 -1.1 -1.4 -1.3 -1.4
Pulse wave peak to peak time 0.3 0.3 0.7 -0.8 0.9 0.7 -0.6 0.5 0.1 -0.0 -0.2
Health satisfaction 0.5 0.6 4.6 0.6 0.4 2.1 0.0 0.1 0.1 0.2 0.1
Shortness of breath walking on level ground 4.2 5.0 8.8 3.0 1.9 1.4 -1.6 2.6 -1.9 -2.4 -2.6
Qualifications: College or University degree 2.5 8.0 20.5 -1.6 -4.5 -2.8 3.6 -4.2 -1.4 -0.6 -0.6
Eye problems/disorders: None of the above 0.3 0.4 1.0 0.8 0.6 1.0 -0.2 0.5 -0.1 -0.5 -0.5
Mouth/teeth dental problems: Loose teeth 1.6 2.0 5.7 1.3 2.0 1.3 -2.4 1.6 0.1 -0.1 -0.2
Emphysema/chronic bronchitis 0.4 0.5 1.3 0.2 -1.0 -0.5 0.5 -1.1 -0.6 -0.7 -0.4
Medication for pain relief, constipation, heartburn 1.9 3.2 6.4 -2.0 -1.6 -1.0 0.6 -2.5 1.6 2.0 2.2
Neck or shoulder pain in last month 0.7 1.0 2.3 1.0 1.1 1.5 -1.1 0.6 0.9 0.8 0.6
Medication: Blood pressure 0.6 1.0 4.0 2.0 0.6 1.0 -0.4 1.4 -0.6 -0.5 -0.5
Angina (self-reported) 1.1 1.5 3.6 -0.8 -1.9 -0.6 1.0 -1.9 0.6 1.1 1.1
Migraine (self-reported) 1.5 1.9 3.6 0.5 1.6 0.2 -1.0 1.7 -1.3 -1.9 -1.7
Medication: Ibuprofen 0.4 0.4 0.8 -0.7 0.7 0.6 -0.2 0.8 -0.5 -0.6 -0.9
Medication: Allopurinol 0.9 1.3 4.3 1.4 0.3 2.1 0.1 1.3 -0.4 -0.9 -1.0
Medication: Omeprazole 0.5 0.6 1.3 0.1 0.4 1.0 -0.4 0.8 -0.7 -1.1 -1.0
Medication: Seretide 50 evohaler 3.1 3.6 8.3 1.9 2.9 2.3 -1.9 2.7 0.2 -0.5 -0.7
Mean time to correctly identify matches 1.0 1.9 5.8 0.4 2.4 -0.1 -1.4 2.0 1.0 1.1 0.8
Heart disease (mother) 3.3 4.0 9.7 -1.0 -2.4 -2.5 1.4 -3.1 0.8 1.8 1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 3.3 1.8 -1.2 -1.4 1.0 -0.3 -0.1 0.1 -0.2
Whole body fat mass 1.1 4.6 10.4 2.3 2.2 2.8 -1.3 3.2 -0.7 -1.8 -1.8
Leg fat mass (right) 0.7 2.8 6.7 1.6 1.7 2.4 -0.9 2.6 -0.4 -1.4 -1.4
Arm predicted mass (right) 0.7 3.6 10.0 -1.9 -3.2 -1.4 2.1 -2.3 -1.2 -1.2 -1.0
Pulse rate, automated reading 3.4 11.0 27.8 2.1 5.3 3.5 -4.2 4.8 0.7 -0.9 -0.8
Alcohol intake frequency. 4.3 9.9 24.7 2.5 5.0 3.2 -4.4 4.2 0.8 -0.6 -0.7
Comparative height size at age 10 0.3 1.8 3.2 -1.4 -1.4 -0.8 0.5 -0.8 -1.7 -1.7 -1.8
Number of full sisters 1.0 1.3 2.0 -0.9 -0.9 -0.7 1.4 -1.3 1.0 1.4 1.1
Suffer from ‘nerves’ 1.1 1.7 4.6 1.0 1.8 0.6 -1.6 2.1 -0.3 -0.8 -0.9
Overall health rating 4.3 9.2 19.0 2.3 4.3 4.4 -3.6 3.4 2.1 1.1 0.9
Chest pain or discomfort 0.4 0.6 2.6 -0.7 -0.9 -1.6 -0.1 -1.0 0.3 0.2 0.5
Had major operations 1.6 1.9 5.9 2.4 -0.2 1.0 0.5 0.9 -1.4 -1.6 -1.5
Age at last live birth 0.8 1.2 2.5 0.3 1.6 1.5 -1.5 1.4 0.1 -0.3 -0.5
Family relationship satisfaction 0.6 0.7 1.6 -0.2 0.6 -0.2 0.7 0.2 1.2 1.3 1.2
Leg pain on walking 1.5 1.9 6.0 -0.3 -2.1 -0.4 2.5 -1.3 -1.3 -0.8 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.9 -1.0 0.5 0.0 -0.1 0.7 -0.1 -0.2 -0.1
Commuting to job workplace: Car/motor vehicle 1.6 1.8 5.0 0.5 2.1 -0.7 -2.2 1.8 -0.2 -0.7 -0.9
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 2.5 -1.6 -0.9 -0.7 0.8 -1.2 0.8 1.1 0.9
Medication: Aspirin 0.5 0.6 1.3 0.3 0.6 0.7 0.2 0.7 1.1 1.2 1.1
Supplements: Vitamin C 1.3 1.5 3.1 1.0 1.2 -0.4 -1.0 1.8 -1.0 -1.4 -1.5
Knee pain experienced in last month 0.4 0.6 1.7 0.1 -0.0 1.0 1.3 0.8 -0.5 -0.6 -0.7
Hypertension (Self-reported) 1.1 2.9 5.9 1.8 -0.6 2.3 0.7 -0.3 1.9 2.1 2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 1.3 -1.1 -0.2 0.4 -1.1 0.5 -0.7 -0.8 -0.5
Illnesses of father: Heart disease 1.0 1.4 3.5 0.0 -0.7 -0.6 1.2 -0.7 1.5 1.6 1.9
Illnesses of siblings: Diabetes 0.1 0.2 0.5 0.2 0.4 0.3 -0.3 0.7 -0.2 -0.5 -0.3
Smoking status: Previous 0.7 1.0 2.2 -1.1 0.0 -0.7 -0.4 -0.6 1.3 1.4 1.5
Forced expiratory volume in 1-second (FEV1), predicted 2.6 5.5 12.1 -0.8 -2.0 -3.1 1.0 -1.0 -3.5 -2.6 -2.9
Whole body fat-free mass 0.7 4.3 9.1 -1.4 -3.0 -1.5 1.9 -1.7 -2.3 -2.2 -2.0
Leg fat-free mass (right) 0.4 2.1 5.2 -0.2 -1.3 -0.4 0.8 -0.0 -2.1 -2.3 -2.2
Arm fat percentage (left) 2.5 10.1 24.7 3.3 4.2 4.2 -2.4 5.0 -0.0 -1.4 -1.6
Average weekly red wine intake 9.9 14.7 39.6 -1.9 -6.3 -3.9 5.6 -5.1 -1.3 0.1 0.3
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.8 0.1 0.6 -0.8 -0.5 0.9 -0.5 -0.4 -0.5
Mood swings 3.7 6.7 13.9 2.9 3.1 2.3 -2.8 3.7 -1.1 -1.8 -2.0
Loneliness, isolation 4.5 6.2 14.0 2.5 3.7 1.8 -3.6 3.5 0.0 -0.7 -0.9
Long-standing illness, disability or infirmity 0.2 0.2 1.2 1.1 0.1 0.5 -0.6 0.0 -0.2 0.2 0.1
Ever had bowel cancer screening 1.0 1.2 2.1 0.1 -1.0 -0.8 1.0 -1.4 1.1 1.3 1.4
Diabetes diagnosed by doctor 0.8 1.2 2.9 0.6 0.4 0.9 -0.5 0.5 1.5 1.7 1.7
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.7 -0.3 -0.6 -0.5 0.8 0.2 -0.6 -0.6 -0.7
Friendships satisfaction 0.3 0.4 1.6 -0.7 0.5 1.2 -0.3 0.2 0.5 0.3 0.4
Qualifications: nursing, teaching 2.9 4.4 14.6 -0.2 -3.8 -2.2 2.1 -2.7 -1.6 -1.1 -0.9
Commuting to job workplace: Walk 0.7 0.8 2.7 0.1 -1.6 -1.1 0.6 -1.3 -0.3 0.1 0.0
Eye problems/disorders: Cataract 0.1 0.1 0.3 0.6 -0.0 -0.1 -0.1 -0.0 0.3 0.5 0.4
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 2.6 0.8 0.6 0.5 -0.3 1.0 -1.1 -1.5 -1.6
Medication for cholesterol 2.0 3.0 7.8 1.0 0.7 -0.6 -1.3 0.8 -2.4 -2.6 -2.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 1.0 0.4 -0.0 -0.6 -1.0 -0.2 0.2 0.2 0.1
Back pain experienced in last month 0.4 0.6 1.5 -0.2 0.5 1.2 -0.9 1.0 -0.3 -0.8 -0.8
Mineral and other dietary supplements 2.7 3.6 7.0 1.3 2.6 2.1 -1.5 2.0 2.2 1.6 1.5
Breast cancer (self-reported) 0.8 0.9 3.2 0.9 1.5 0.8 -0.5 1.8 0.4 -0.4 -0.2
Asthma (self-reported) 1.7 3.4 6.4 -0.5 1.6 1.4 -1.9 1.8 -1.9 -2.5 -2.5
Osteoporosis (self-reported) 1.4 1.7 5.0 0.7 -0.4 2.2 0.5 -0.9 1.8 1.3 1.4
Osteoarthritis (self-reported) 0.2 0.3 0.5 0.7 0.2 0.7 0.6 0.7 -0.4 -0.5 -0.3
Medication: Aspirin 0.3 0.4 1.2 -0.1 0.0 0.2 0.4 0.0 0.9 1.1 1.1
Medication: Gliclazide 0.4 0.4 2.1 1.4 -0.0 0.3 -0.7 -0.1 0.5 0.5 0.6
Illnesses of father: None of the above (group 1) 0.7 0.8 1.7 -0.2 0.7 -0.7 -0.8 0.6 -1.3 -1.1 -1.3
Smoking status: Current 2.3 3.6 9.5 -0.1 2.7 1.6 -2.4 3.1 -0.5 -1.3 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.2 4.7 23.6 -0.0 -3.0 -1.1 4.9 -1.9 -0.4 -0.2 -0.1
Whole body water mass 0.7 3.8 8.0 -1.3 -2.8 -1.3 1.8 -1.6 -2.2 -2.2 -1.9
Leg predicted mass (right) 0.4 2.3 5.7 -0.2 -1.3 -0.4 0.8 0.0 -2.2 -2.4 -2.3
Arm fat mass (left) 1.3 5.4 12.5 2.3 2.6 3.0 -1.6 3.5 -0.7 -1.8 -1.9
Number of self-reported non-cancer illnesses 0.4 0.8 2.3 -0.7 -0.2 0.5 0.3 -0.4 1.1 1.3 1.5
Average weekly champagne plus white wine intake 0.1 0.1 0.3 0.2 -0.5 -0.1 0.5 -0.5 -0.2 -0.3 -0.2
Miserableness 1.8 3.2 6.4 1.3 2.4 1.9 -2.1 2.5 -0.8 -1.1 -1.4
Guilty feelings 9.7 14.6 32.8 2.8 5.1 2.9 -5.1 5.7 -1.4 -2.6 -2.7
Wears glasses or contact lenses 2.8 3.3 7.9 -1.4 -2.8 -1.7 2.1 -2.3 -1.4 -0.8 -1.1
Ever taken oral contraceptive pill 2.8 3.1 10.3 -3.2 -2.1 -2.0 1.4 -1.7 -1.0 -0.4 -0.3
Hearing aid user 1.3 1.5 5.1 0.7 -2.3 -0.9 1.3 -1.7 -0.9 -0.3 -0.2
Mother’s age at death 0.6 0.8 1.5 -1.1 -0.1 0.7 0.6 0.7 -1.0 -1.2 -1.2
Financial situation satisfaction 1.0 1.2 4.2 0.5 2.0 0.9 -0.1 2.1 0.5 0.5 0.2
Tinnitus: Yes, now most or all of the time 0.9 1.1 2.3 0.8 1.5 1.0 -1.3 1.2 0.6 0.8 0.7
Commuting to job workplace: Public transport 1.0 1.2 3.9 -0.2 -2.0 -0.7 1.7 -1.4 -0.6 0.2 0.3
Eye problems/disorders: Glaucoma 3.1 3.6 6.4 -2.2 -2.5 -2.5 1.6 -1.9 -1.7 -1.3 -1.0
Medication: Blood pressure 1.9 3.7 9.2 -0.2 -1.4 0.6 1.3 -1.8 2.3 2.7 3.0
Pain type(s) experienced in last month: Hip pain 1.3 1.7 5.9 0.5 0.6 2.4 -0.4 1.3 -0.8 -1.6 -1.5
Supplements: Fish oil (including cod liver oil) 2.4 3.1 7.4 -1.3 -2.5 -2.7 1.9 -2.1 -1.0 -0.6 -0.4
High cholesterol (Self-reported) 0.8 1.5 3.5 0.9 0.8 0.7 0.4 0.7 1.9 1.6 1.9
Medication: Bendroflumethiazide 0.3 0.5 1.7 0.4 -1.3 0.5 0.6 -1.1 0.2 0.3 0.7
Medication: Paracetamol 3.9 6.0 9.9 2.3 2.6 2.1 -2.1 3.1 -1.8 -2.7 -2.6
Medication: Lisinopril 0.4 0.5 2.1 0.8 -0.8 -0.4 1.4 -0.3 0.0 -0.0 0.1
Medication: Atorvastatin 1.8 2.3 5.2 -1.1 -0.7 -0.0 1.4 -0.6 2.2 2.1 2.3
Illnesses of father: High blood pressure 1.7 2.1 3.9 0.1 -1.6 0.6 2.0 -1.6 1.6 1.4 1.8
Alcohol drinker status: Never 3.2 3.9 6.3 2.1 1.8 2.5 -1.7 2.5 -0.8 -1.9 -1.8
Ever smoked 0.9 1.5 4.0 -1.6 1.5 0.7 -2.0 1.4 -0.3 -0.7 -0.6
Basal metabolic rate 0.6 3.1 6.2 -0.7 -2.1 -0.7 1.3 -0.7 -2.3 -2.5 -2.3
Leg fat percentage (left) 1.2 4.2 10.3 1.9 2.7 3.2 -1.4 3.1 0.5 -0.5 -0.6
Arm fat-free mass (left) 0.6 3.1 8.2 -1.2 -2.9 -1.3 1.9 -1.8 -1.6 -1.4 -1.3
Number of operations (self-reported) 1.5 2.2 4.5 -0.1 -1.9 -1.1 2.1 -0.8 -1.8 -1.6 -1.5
Average weekly beer plus cider intake 1.2 1.7 3.6 -1.1 -1.2 -0.6 0.5 -1.9 1.3 1.5 1.8
Irritability 4.5 7.6 16.4 2.6 3.3 2.0 -4.0 3.6 -1.2 -1.9 -2.1
Risk taking 1.5 2.2 5.2 -0.4 -0.6 -1.3 0.5 0.3 -2.3 -2.2 -2.2
Ever had prostate specific antigen (PSA) test 0.9 1.1 4.1 -0.3 -1.9 0.3 0.8 -2.0 -0.3 -0.1 -0.1
Fractured/broken bones in last 5 years 0.9 1.2 2.6 -1.6 -1.4 -0.7 1.3 -1.4 0.3 0.4 0.5
Age started oral contraceptive pill 1.0 1.2 2.6 -0.5 -1.1 -0.2 0.8 -0.9 -1.5 -1.6 -1.4
Diastolic blood pressure, automated reading 1.6 4.8 13.3 0.7 -0.7 0.9 1.5 -1.0 3.1 3.3 3.6
Ever depressed for a whole week 1.1 1.3 3.1 -0.0 1.8 0.2 -1.3 1.4 1.1 1.1 1.1
Unable to work because of sickness or disability 5.5 7.1 13.8 2.4 3.7 3.1 -3.3 3.7 -0.1 -1.1 -1.2
Commuting to job workplace: Cycle 2.3 2.8 8.5 -1.0 -2.6 -0.3 2.1 -2.9 0.4 0.7 1.0
Myopia 0.2 0.4 1.1 -0.8 0.7 1.0 -0.5 0.5 -0.0 -0.3 -0.3
Vascular/heart problems diagnosed by doctor 1.2 3.3 7.0 -1.4 0.6 -2.3 -1.2 0.2 -2.2 -2.4 -2.6
Cholesterol lowering medication 1.4 2.0 4.8 0.4 1.1 0.8 -0.2 0.7 2.2 2.0 2.1
Medication: Omeprazole (e.g. Zanprol) 0.4 0.4 1.6 0.3 0.4 1.3 -0.9 0.6 -0.1 -0.6 -0.3
Pain experienced in last month 3.4 5.6 12.0 -2.3 -3.2 -2.8 2.5 -3.5 0.4 1.1 1.4
Supplements: Calcium 0.2 0.2 0.5 -0.7 -0.2 -0.3 -0.3 -0.2 0.4 0.6 0.5
Basal cell carcinoma (self-reported) 0.3 0.3 0.6 -0.4 -0.1 0.4 0.4 -0.8 0.8 0.6 0.6
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.4 -0.7 -0.2 -0.3 -0.6 -0.7 1.1 0.9 1.2
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 4.5 2.1 1.2 0.8 -0.5 1.4 -0.5 -0.7 -1.1
Heart disease (siblings) 1.6 2.0 5.6 -0.6 0.4 0.5 -0.2 -0.9 2.0 2.2 2.4
Alcohol drinker status: Previous 4.9 5.6 9.9 2.6 3.1 1.4 -2.9 3.1 -1.2 -1.7 -2.1
Pack years of smoking 2.9 4.3 9.7 1.8 3.1 2.7 -2.1 3.0 0.1 -0.4 -0.7
Impedance of whole body 0.7 3.8 7.2 1.2 2.6 1.6 -2.2 2.7 -1.1 -1.5 -1.9
Leg fat mass (left) 0.7 2.8 6.8 1.6 1.7 2.4 -1.0 2.6 -0.4 -1.3 -1.4
Arm predicted mass (left) 0.5 2.4 6.7 -1.2 -2.6 -1.0 1.5 -1.6 -1.4 -1.3 -1.1