Hub : Genes

ZDHHC5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.0952	0.0376	1.2e-03	-0.002	NA	0.003	NA	0.000	4.7e-01	NA	1.7e-01	NA	3.1e-01
2	GTEx	Skin Sun Exposed Lower leg	0.0510	0.0210	6.4e-04	0.029	NA	0.020	NA	0.022	1.7e-03	NA	8.6e-03	NA	6.2e-03
3	GTEx	Whole Blood	0.0600	0.0300	4.8e-03	0.002	NA	-0.002	NA	-0.002	2.2e-01	NA	4.8e-01	NA	5.7e-01
4	ROSMAP	Brain Pre-frontal Cortex	0.0488	0.0222	1.4e-03	0.019	0.027	0.015	0.026	0.013	1.5e-03	2.0e-04	4.1e-03	2.1e-04	6.4e-03
5	YFS	Blood	0.0586	0.0144	0.0e+00	0.074	0.065	0.073	0.069	0.072	3.2e-23	2.6e-20	1.2e-22	1.2e-21	2.2e-22
6	TCGA	Breast Invasive Carcinoma	0.0159	0.0103	2.0e-03	0.006	0.012	0.007	NA	0.010	2.0e-02	1.5e-03	1.4e-02	NA	2.9e-03
7	TCGA	Colon Adenocarcinoma	0.1050	0.0710	1.3e-03	0.045	0.042	0.028	NA	0.038	1.3e-03	1.8e-03	9.3e-03	NA	2.9e-03
8	TCGA	Prostate Adenocarcinoma	0.0990	0.0453	2.0e-09	0.113	0.096	0.100	NA	0.107	7.7e-12	2.9e-10	1.2e-10	NA	2.9e-11

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bipolar Disorder (2018)	0.6	1.0	2.7	1.6	-0.1	-0.2	0.1	0.2	-1.3	-1.3	-1.3
Bipolar Disorder or Schizophrenia	2.9	7.1	12.5	3.2	3.2	3.5	-2.8	3.5	-0.7	-1.1	-1.6
Depressed Affect (Nagel 2018)	4.5	9.5	18.4	3.0	3.8	3.1	-4.3	4.1	-0.9	-1.8	-2.0
Depression (Nagel 2018)	8.2	12.4	27.0	2.4	5.2	3.6	-4.8	5.2	-0.0	-1.1	-1.4
Intelligence (Savage-Jansen 2018)	2.4	7.4	19.1	-1.9	-4.4	-2.7	3.0	-4.3	0.1	0.6	1.0
Neuroticism (Nagel 2018)	9.7	22.9	44.9	4.9	6.3	4.2	-6.6	6.7	-0.7	-2.4	-2.5
Schizophrenia (2018)	4.8	10.0	22.6	2.7	4.2	4.8	-3.6	4.4	0.2	-0.4	-1.0
Schizophrenia vs Biploar Disorder	4.6	6.0	13.8	0.6	3.7	1.3	-2.6	2.6	2.9	2.4	2.1
Worry (Nagel 2018)	4.5	9.5	19.1	4.3	3.7	2.8	-3.5	4.4	-0.5	-1.5	-1.6
Alzheimer’s Disease (in mother)	0.3	0.4	1.0	-0.7	0.7	-0.5	-1.0	0.4	-0.1	-0.5	-0.5
Alzheimer’s Disease (in father)	0.4	0.4	1.1	0.4	0.8	1.0	-0.7	0.9	-0.2	0.1	-0.2
Alzheimer’s Disease (including proxy)	0.5	0.7	2.2	-0.1	1.5	0.8	-1.0	1.2	0.1	-0.2	-0.4
Crohns Disease (2017)	0.6	1.3	4.9	2.2	-0.8	1.7	0.8	-0.9	0.3	0.0	0.4
Irritable Bowel Disease (IBD)	0.8	1.8	9.4	3.1	-0.9	1.6	0.9	-0.9	0.2	0.0	0.4
Ulcerative Colitis (UC)	0.5	1.0	6.2	2.5	-0.3	1.2	0.4	-0.2	0.1	-0.1	0.3
Major Depression (MDD)	8.9	10.8	25.7	2.1	5.1	4.0	-4.0	4.5	1.9	0.3	0.3
Reaction Time	0.7	1.3	4.2	0.9	2.0	-0.5	-0.7	1.9	0.6	0.8	0.3
Verbal and Numeric Reasoning (VNR)	2.6	6.3	16.4	-2.0	-4.1	-2.8	2.3	-4.0	0.3	0.7	1.1
Breast Cancer	1.9	4.6	10.7	-0.6	-3.3	-3.2	1.6	-2.4	-2.0	-1.2	-1.2
Ovarian Cancer	0.8	1.1	2.1	-0.6	-1.2	-0.8	1.3	-1.5	0.3	1.1	1.0
Prostate Cancer	2.4	3.4	7.9	-2.0	-2.2	-2.3	1.5	-2.8	0.3	1.0	1.2
Age at First Birth	1.0	1.5	3.6	-0.1	0.4	-0.7	-0.7	1.1	-1.8	-1.7	-1.9
Bipolar Disorder (2011)	1.4	1.3	6.8	2.6	0.6	0.6	-0.1	1.2	-0.8	-0.7	-0.8
Body Mass Index (BMI) (2010)	1.4	1.9	4.8	1.4	1.7	1.1	-0.9	2.2	-0.7	-1.1	-1.5
Coronary Artery Disease (CAD)	3.0	3.6	10.7	0.5	0.7	0.4	0.4	-0.1	3.3	2.9	3.0
Crohns Disease (2012)	0.7	1.1	2.8	0.9	-1.7	0.0	1.6	-1.6	0.2	0.1	0.3
Mean Putamen Volume	1.4	1.6	5.8	-0.3	-1.5	-1.0	2.4	-1.6	0.4	0.8	0.8
Fasting Glucose	1.0	1.2	3.2	-0.1	-0.5	-0.7	-0.1	0.2	-1.6	-1.6	-1.8
HbA1C	0.9	1.0	2.5	-0.8	-0.3	-1.6	0.0	-0.6	-1.0	-1.5	-1.1
HDL Cholesterol	0.7	1.1	2.7	0.1	1.2	-0.7	-1.1	1.6	-1.0	-1.0	-1.2
LDL Cholesterol	0.8	1.2	3.0	-1.0	-0.3	-0.3	0.4	-0.6	1.4	1.7	1.7
Lupus	0.8	1.1	3.5	-0.3	0.7	0.3	-0.3	-0.1	1.9	1.4	1.7
Neuroticism (2016)	3.5	5.1	12.6	1.2	3.0	1.7	-3.6	3.4	-0.4	-1.2	-1.2
Primary Biliary Cirrhosis	1.6	2.3	5.3	0.4	1.4	0.7	-0.6	0.3	2.3	2.1	2.2
Rheumatoid Arthritis	0.2	0.3	1.9	-0.8	-0.1	1.4	0.3	0.1	0.3	0.1	0.2
Schizophrenia (2014)	4.8	10.5	21.6	2.6	4.6	4.2	-4.0	4.6	0.4	-0.4	-0.8
Triglycerides	1.2	2.0	5.2	0.7	0.8	1.9	0.5	0.6	2.3	1.7	1.5
Type 2 Diabetes (T2D) (2012)	0.5	0.5	2.4	0.4	-0.2	-1.0	1.6	0.1	-0.6	-0.2	-0.4
Ulcerative Colitis	0.7	1.0	2.7	0.9	-1.6	0.4	1.5	-1.2	-0.7	-0.6	-0.2
Blood Eosinophil Count	1.2	9.4	27.6	0.0	4.5	1.7	-5.2	3.3	-1.3	-2.1	-2.8
Blood Platelet Count	4.1	47.7	96.2	9.5	9.8	6.6	-8.1	8.3	-0.4	-2.8	-2.8
Blood Red Count	1.9	18.8	36.2	3.8	4.9	4.2	-4.3	6.0	-2.6	-3.8	-4.2
Blood White Count	0.4	2.8	5.5	2.3	0.9	1.4	-0.9	1.9	-1.5	-1.8	-2.1
Heel T-Score	1.3	10.3	32.0	-0.1	5.7	2.9	-3.5	4.7	2.5	0.9	0.8
BMI	0.7	3.8	11.3	2.4	2.7	2.0	-1.3	3.4	0.1	-0.6	-0.7
Height	1.6	31.4	64.0	-3.8	-5.3	-4.8	1.8	-2.7	-8.0	-7.5	-7.3
Waist Hip Ratio (WHR)	0.7	3.0	7.3	0.1	0.1	-0.5	-1.0	1.2	-2.7	-2.7	-2.6
Systolic Blood Pressure	5.9	29.4	52.0	-1.2	-6.7	-2.2	6.6	-7.2	3.9	5.8	6.2
Smoking Status	0.9	2.1	5.5	-1.2	2.1	-0.2	-2.2	2.3	-0.1	-0.5	-0.5
Allergy or Eczema	0.1	0.2	0.6	-0.4	0.4	0.8	-0.4	0.4	-0.3	-0.1	-0.0
Cardiovascular Disease	1.3	4.1	9.3	1.6	0.3	2.4	0.6	0.1	2.8	2.7	3.0
Hypothyroidism (self reported)	1.7	3.9	9.5	0.4	-0.7	-0.5	0.7	-1.5	2.9	3.0	3.1
Respiratory disease	2.1	4.6	8.8	-0.6	1.8	1.3	-2.2	2.0	-2.4	-2.9	-3.0
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.2	0.4	-0.6	0.2	0.6	-0.5	1.0	1.4	1.5
Lung FEV1/FVC ratio	2.9	14.5	36.7	-1.8	-6.1	-3.7	6.0	-4.1	-2.5	-1.5	-1.4
Lung FVC	0.3	1.5	4.1	-0.7	-0.2	1.1	2.0	-0.6	1.7	1.1	1.2
Neuroticism	9.7	23.3	48.1	4.9	6.7	3.7	-6.7	6.9	-0.8	-2.0	-2.5
Chronotype (morning person)	2.9	6.7	19.7	-0.1	-4.4	-1.5	4.3	-3.2	-1.5	-0.8	-0.6
Hair Pigment	0.1	1.5	3.6	-1.2	0.5	-1.0	0.3	-0.2	1.9	1.4	1.9
Tanning	0.4	4.3	10.4	-0.5	-3.0	-2.7	3.2	-2.5	-0.3	0.6	0.7
Hand grip strength (left)	2.9	7.7	16.0	-3.5	-3.8	-4.0	3.0	-2.5	-1.7	-0.8	-0.8
Number of treatments/medications taken	0.4	0.8	2.5	0.7	0.6	1.6	-0.6	1.1	-0.5	-0.8	-0.7
Average weekly spirits intake	0.5	0.6	1.0	0.3	0.8	0.5	-0.8	0.7	-1.0	-0.9	-0.9
Sensitivity / hurt feelings	5.8	10.0	19.2	3.8	4.1	1.1	-4.1	4.4	-1.1	-2.3	-2.2
Frequency of depressed mood in last 2 weeks	7.0	9.8	23.7	2.2	4.9	3.0	-4.5	4.4	0.9	0.0	-0.2
Hearing difficulty/problems: Yes	3.2	4.8	11.5	3.0	2.6	2.9	-1.7	3.4	-0.1	-0.3	-0.6
Relative age of first facial hair	0.2	0.3	0.9	-0.8	-0.4	0.9	0.6	-0.4	0.1	-0.3	-0.5
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.3	1.1	0.8	1.0	-0.7	0.7	0.9	0.4	0.6
Ever used hormone-replacement therapy (HRT)	1.5	1.9	5.7	-0.8	1.1	1.4	-0.1	0.4	2.4	1.6	1.7
Ever had hysterectomy (womb removed)	1.8	2.0	4.4	-0.6	-1.8	0.0	1.4	-2.1	1.4	1.3	1.5
Systolic blood pressure, automated reading	4.6	13.3	22.4	-1.1	-4.3	-1.5	4.2	-4.7	2.9	4.2	4.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.5	-0.5	-1.2	-0.3	0.8	-1.1	0.1	0.3	0.3
Angina	1.1	1.4	3.8	-0.9	-1.9	-0.4	1.0	-1.8	0.5	0.9	1.0
Medication for hormone replacement therapy	0.6	0.7	3.8	-2.0	0.5	0.2	-0.0	0.4	0.5	0.6	0.6
Vitamin and mineral supplements	0.9	1.2	2.9	-1.2	-1.3	-1.4	1.7	-1.1	-0.3	0.6	0.2
Supplements: Zinc	0.5	0.5	2.7	-1.6	0.0	-0.7	-0.8	-0.1	-0.2	0.2	0.4
Medication: Co-codamol	1.8	2.1	5.0	2.2	1.7	1.9	-0.9	1.9	-0.2	-0.6	-0.4
Medication: Metformin	0.2	0.3	0.7	0.5	0.4	0.1	-0.6	0.6	0.4	0.8	0.8
Diabetes (father)	0.4	0.5	1.4	-0.0	-0.3	0.9	-0.2	-0.1	-1.0	-0.9	-1.2
Diabetes (mother)	0.4	0.5	1.6	0.3	-0.7	-0.4	-0.0	0.3	-0.9	-1.3	-1.0
Severe depression (siblings)	1.1	1.3	3.2	-0.6	0.9	-0.3	-1.8	0.8	-1.3	-1.3	-1.3
Pack years adult smoking proportion	3.3	5.0	10.9	2.1	3.3	2.8	-2.3	3.3	0.0	-0.5	-0.8
Impedance of leg (right)	0.1	0.5	1.2	-0.1	0.5	0.5	-0.8	0.5	-0.7	-0.8	-1.1
Leg fat-free mass (left)	0.4	2.2	6.0	-0.1	-1.2	-0.2	0.6	0.1	-2.1	-2.4	-2.3
Trunk fat percentage	2.5	10.0	23.5	3.3	4.1	4.1	-2.4	4.8	-0.2	-1.5	-1.8
Hand grip strength (right)	1.9	5.1	11.4	-2.2	-3.4	-2.2	3.3	-2.1	-1.6	-0.9	-1.0
Townsend deprivation index at recruitment	5.2	7.3	16.6	2.7	4.1	3.8	-2.6	3.5	1.3	0.3	0.1
Current tobacco smoking	2.2	3.7	10.0	0.1	2.7	1.9	-2.2	3.2	-0.4	-1.3	-1.3
Average weekly fortified wine intake	0.3	0.3	1.5	-0.9	-0.0	-1.2	0.0	-0.4	0.1	0.3	0.3
Maternal smoking around birth	0.3	0.5	1.3	0.8	0.2	1.1	-0.4	-0.2	0.7	0.8	0.8
Fed-up feelings	7.2	13.1	24.2	3.9	4.9	4.7	-4.4	4.8	0.6	-0.5	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	7.1	9.5	25.1	1.4	5.0	3.3	-3.9	4.7	0.4	-0.5	-0.8
Relative age voice broke	0.5	0.7	4.0	-2.0	0.1	0.4	-0.1	-0.4	0.7	0.6	0.6
Taking other prescription medications	1.3	2.0	3.5	0.9	1.4	1.0	-1.3	1.9	-1.1	-1.6	-1.7
Age when periods started (menarche)	1.6	3.9	10.2	0.7	-0.3	-0.9	0.1	0.8	-3.0	-3.2	-3.2
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.4	-0.4	-1.5	-0.5	1.4	-1.1	0.5	0.8	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.7	0.0	0.4	-0.8	-0.4	1.1	-1.1	-1.6	-1.6
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	4.0	-0.1	-0.0	0.2	0.2	0.5	-1.8	-1.9	-2.0
Qualifications: CSEs or equivalent	3.2	4.2	12.1	1.9	3.1	2.4	-1.4	3.5	0.7	0.3	0.2
Serious illness, injury or assault to yourself	0.8	1.0	3.0	1.0	-0.2	0.6	-0.2	0.1	-1.3	-1.7	-1.4
High blood pressure	1.0	2.8	6.2	1.8	-0.3	2.5	0.7	0.2	1.9	2.0	2.2
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.8	-0.3	-0.5	-0.1	0.1	-0.3	-0.9	-0.6	-0.5
Multivitamins +/- minerals	0.4	0.6	1.6	0.4	1.0	1.2	-0.7	0.7	0.8	0.1	0.6
Stomach or abdominal pain in last month	0.6	0.8	3.0	1.7	0.5	1.1	-0.8	0.8	-0.3	-0.4	-0.4
Supplements: Glucosamine	1.3	1.7	3.3	-1.4	-1.8	-1.8	1.2	-1.4	-1.2	-0.5	-0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	-0.4	0.1	-0.7	-0.3	0.6	-0.7	-0.2	-0.5
Medication: Atenolol	0.6	0.7	1.3	0.5	1.1	0.9	-1.0	1.0	0.7	0.9	0.7
Medication: Levothyroxine sodium	1.2	2.0	5.0	0.1	-0.2	1.1	0.1	-0.8	2.2	2.0	2.2
Sitting height	1.9	13.3	34.2	-3.8	-5.8	-3.5	3.5	-5.4	-1.9	-0.7	-0.7
Chronic bronchitis/emphysema (father)	1.6	1.8	4.7	-0.4	0.1	-0.1	-0.8	0.8	-2.2	-2.0	-2.1
High blood pressure (mother)	1.1	1.6	4.1	0.1	-2.0	-1.2	2.0	-1.5	0.2	0.7	0.6
Body mass index (BMI)	0.6	2.5	5.9	2.0	1.9	2.4	-0.7	2.4	0.7	-0.2	-0.1
Impedance of leg (left)	0.1	0.7	1.5	-0.1	0.7	0.6	-0.9	0.9	-0.8	-0.9	-1.2
Leg predicted mass (left)	0.4	2.1	5.8	-0.0	-1.2	-0.2	0.6	0.1	-2.1	-2.4	-2.3
Trunk fat mass	1.4	6.1	14.1	2.5	2.7	3.1	-1.6	3.8	-0.9	-2.0	-2.2
Waist circumference	0.7	2.7	5.4	1.7	0.5	1.0	-0.0	2.0	-1.8	-2.3	-2.3
Number of incorrect matches in round	0.2	0.4	0.9	0.7	0.3	-0.5	-0.8	0.0	0.6	0.8	0.9
Past tobacco smoking	0.4	0.8	1.9	1.4	-0.8	-0.1	1.3	-0.4	-0.9	-0.7	-0.9
Alcohol usually taken with meals	7.1	11.5	31.2	-1.4	-5.6	-3.5	4.9	-4.7	-0.8	0.2	0.0
Nervous feelings	0.8	1.6	5.4	2.3	1.2	1.3	-1.6	1.3	0.2	-0.1	0.2
Frequency of tenseness / restlessness in last 2 weeks	3.3	5.1	11.4	2.3	2.7	2.7	-3.4	2.6	-0.4	-0.9	-1.2
Hearing difficulty/problems with background noise	1.2	2.0	5.4	2.3	1.3	1.0	-0.2	1.5	1.6	1.3	1.1
Hair/balding pattern: Pattern 2	4.2	5.3	9.1	-1.4	-3.0	-2.4	2.4	-1.8	-2.8	-2.2	-2.1
Had menopause	1.1	1.4	3.4	-0.8	-0.2	0.4	-0.5	-1.3	1.9	1.4	1.8
Had other major operations	0.3	0.4	1.3	-1.1	-0.8	-1.0	0.5	-0.2	0.0	-0.4	-0.1
Forced vital capacity (FVC)	0.6	2.3	5.8	-1.3	-2.4	-0.2	2.0	-1.5	-1.1	-1.3	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	3.0	-0.6	1.2	-0.8	-0.9	1.7	-0.6	-1.1	-1.1
Ever unenthusiastic/disinterested for a whole week	2.1	2.6	7.0	1.2	2.6	0.5	-2.5	2.1	0.8	0.7	0.5
Qualifications: None of the above	4.0	8.5	20.4	1.7	4.5	3.6	-2.8	3.9	2.3	1.3	1.2
Financial difficulties in last 2 years	2.8	3.8	11.5	0.1	3.4	1.0	-2.5	2.7	1.4	1.1	0.8
Mouth/teeth dental problems	1.8	2.7	7.5	-0.7	-2.7	-2.1	1.7	-2.3	-1.0	-0.1	-0.0
Heart attack	0.3	0.4	0.9	-0.7	-0.3	-0.4	-0.6	-0.6	0.8	0.7	0.9
Allergy	1.1	2.6	5.5	-0.8	-0.7	-0.9	1.1	-1.2	2.3	2.3	2.3
Pain all over the body in last month	3.6	3.9	8.4	2.7	2.9	1.8	-2.2	2.7	0.6	-0.0	-0.0
Diabetes (self-reported)	0.6	0.9	1.9	-0.2	-1.4	-0.6	0.4	-1.1	0.6	1.2	1.4
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	6.2	-2.5	-1.3	-1.2	1.5	-1.4	0.3	0.9	0.7
Medication: Ramipril	0.8	1.0	3.4	-0.4	-1.9	0.1	1.5	-1.3	-0.0	0.6	0.6
Medication: Simvastatin	0.9	1.3	2.8	0.8	-0.6	-0.5	1.6	-0.5	1.3	1.5	1.7
Fluid intelligence score	2.0	4.1	13.0	-0.6	-3.6	-2.3	1.7	-3.2	-0.1	0.5	0.7
Illnesses of siblings	1.6	2.2	6.6	0.0	-0.3	-0.5	0.1	0.6	-2.0	-2.5	-2.6
Neuroticism score	9.8	20.5	46.8	4.6	6.3	3.5	-5.8	6.8	-0.7	-2.0	-2.3
Weight	0.5	2.5	6.4	1.0	0.1	1.1	-0.0	1.5	-1.9	-2.5	-2.5
Impedance of arm (right)	2.5	11.9	25.3	2.7	4.4	2.6	-3.4	5.0	-2.1	-2.9	-3.4
Arm fat percentage (right)	2.8	11.0	27.5	3.4	4.4	4.1	-2.5	5.2	-0.2	-1.5	-1.8
Trunk fat-free mass	1.2	7.0	15.6	-2.1	-4.0	-2.3	2.5	-2.5	-2.8	-2.5	-2.3
Hip circumference	0.6	2.5	5.4	1.4	-0.6	1.1	1.0	1.1	-1.8	-2.3	-2.3
Time employed in main current job	0.2	0.2	0.7	0.8	-0.4	-0.2	0.5	0.1	0.6	0.3	0.4
Alcohol intake versus 10 years previously	0.5	0.7	1.6	-0.1	1.3	0.2	-0.9	1.1	1.2	0.5	0.6
Father’s age at death	1.8	2.4	4.2	-2.0	-0.9	-1.9	0.2	-0.5	-2.0	-1.6	-1.8
Worrier / anxious feelings	8.1	15.3	33.4	5.0	5.2	3.8	-4.2	5.8	-0.1	-1.5	-1.6
Frequency of tiredness / lethargy in last 2 weeks	7.8	12.6	26.9	1.8	5.2	4.9	-4.5	4.9	1.4	-0.5	-0.5
Falls in the last year	1.0	1.4	2.5	0.6	1.2	1.4	-0.9	1.3	-0.8	-1.6	-1.4
Hair/balding pattern: Pattern 3	0.9	1.4	5.7	-2.4	-1.4	-0.9	1.2	-0.9	-0.4	-0.1	-0.0
Number of live births	0.1	0.1	0.4	0.7	0.4	0.6	-0.3	0.3	0.2	-0.1	0.0
Forced expiratory volume in 1-second (FEV1)	2.0	6.9	18.5	-2.3	-4.3	-1.3	4.1	-3.1	-1.2	-1.0	-0.8
Pulse rate	0.8	1.4	2.9	0.0	0.5	-1.2	-1.2	0.7	-1.6	-1.7	-1.6
Happiness	2.9	3.5	6.8	0.3	2.2	2.5	-1.1	1.0	2.6	2.2	1.9
Noisy workplace	0.7	0.9	1.9	-1.4	-0.7	-0.9	1.4	-1.0	0.0	0.7	0.5
Qualifications: A levels/AS levels or equivalent	2.1	4.5	10.1	-2.8	-3.2	-1.9	1.9	-3.2	-1.1	-0.3	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.1	1.5	-1.0	-0.9	0.6	-0.7	-0.9	-0.6	-0.4
Mouth/teeth dental problems: Dentures	1.3	2.1	3.7	-1.0	1.7	1.6	-1.3	0.8	1.9	1.5	1.6
Asthma	1.7	3.4	6.2	-0.6	1.6	1.6	-1.8	1.6	-1.9	-2.5	-2.5
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.2	-0.3	0.9	0.8	-0.1	1.4	-1.1	-1.1	-1.5
Medication: Cholesterol lowering	0.6	0.9	2.3	0.8	-1.4	-1.0	1.5	-0.8	0.2	0.4	0.7
Depression (self-reported)	3.6	4.4	9.4	2.0	3.1	2.2	-2.6	3.0	0.8	-0.3	-0.3
Medication: Lansoprazole	1.2	1.4	5.2	0.7	1.1	2.3	-1.3	1.6	0.4	-0.3	-0.1
Prospective memory result	3.8	4.6	9.7	2.2	3.1	2.7	-2.8	2.4	0.9	0.5	0.3
Lung cancer (father)	1.0	1.2	3.7	0.0	1.5	0.4	-1.9	1.4	-0.5	-0.8	-0.9
Illnesses of mother	0.8	0.9	2.9	-0.0	0.9	1.7	-0.4	1.0	-0.6	-1.0	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.1	15.6	-2.4	-3.8	-1.6	4.0	-2.3	-1.5	-1.3	-1.2
Pulse wave Arterial Stiffness index	0.4	0.5	1.3	0.6	-1.1	-1.0	0.6	-0.6	-0.6	-0.4	-0.2
Impedance of arm (left)	2.2	10.4	20.5	2.5	4.0	2.6	-3.3	4.5	-2.0	-2.8	-3.2
Arm fat mass (right)	1.4	5.8	13.5	2.5	2.6	3.1	-1.6	3.7	-0.8	-1.8	-1.9
Trunk predicted mass	1.2	7.0	15.5	-2.1	-3.9	-2.3	2.5	-2.4	-2.7	-2.5	-2.2
Standing height	1.5	15.4	31.5	-2.3	-4.1	-3.0	1.5	-1.9	-5.6	-5.2	-5.2
Length of working week for main job	0.7	0.8	1.4	-1.1	-0.2	-0.6	-1.1	-0.1	-1.2	-0.9	-1.1
Exposure to tobacco smoke at home	1.7	1.9	3.9	0.9	2.0	1.1	-1.9	1.6	1.1	1.0	0.9
Breastfed as a baby	0.7	0.9	3.6	-1.9	-0.8	-1.5	0.5	-0.7	-0.3	-0.1	0.0
Tense / ‘highly strung’	3.7	6.2	13.4	3.0	3.7	1.7	-3.2	3.6	0.2	-0.5	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	4.3	6.5	15.0	2.7	3.6	2.3	-3.1	3.9	-0.4	-0.9	-1.1
Hair/balding pattern: Pattern 4	2.3	5.5	13.8	1.1	0.2	1.5	-0.1	-1.3	3.7	3.4	3.7
Birth weight of first child	1.5	2.7	6.2	-0.7	-1.1	-1.9	0.3	-0.4	-2.4	-2.2	-2.5
Peak expiratory flow (PEF)	2.4	5.7	13.7	-1.7	-3.7	-1.0	3.6	-2.5	-1.8	-1.5	-1.6
Pulse wave reflection index	0.4	0.5	1.4	1.2	-0.5	0.9	0.5	-0.4	0.7	0.3	0.6
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.6	1.6	0.4	0.4	1.0	1.6	-0.5	-1.0	-1.0
Loud music exposure frequency	1.1	1.2	1.9	0.4	1.2	1.2	-1.1	1.4	-0.9	-1.2	-1.2
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	6.6	-1.5	-2.6	-2.3	1.1	-2.4	-1.2	-0.8	-0.6
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	3.1	0.8	-0.9	0.1	1.8	-0.4	0.0	0.0	-0.1
Blood clot in the leg (DVT)	1.3	1.7	5.3	2.3	1.6	0.8	-0.9	1.7	-0.2	-0.5	-1.0
Medication: Paracetamol	3.8	6.3	10.0	2.6	2.4	1.4	-1.8	3.2	-2.2	-3.0	-3.0
Headache pain in last month	6.1	10.4	18.6	2.2	3.6	2.4	-3.2	4.3	-2.2	-3.5	-3.7
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	2.5	-1.6	0.4	0.2	-0.4	-0.3	0.3	0.1	-0.0
Glaucoma (self-reported)	2.3	2.7	5.9	-1.4	-2.4	-2.2	2.1	-1.8	-1.0	-0.6	-0.3
Gout (self-reported)	0.4	0.6	1.8	0.3	-1.0	1.3	1.1	-0.1	-0.2	-0.6	-0.4
Hypothyroidism/myxoedema (self-reported)	2.0	3.8	9.0	-0.5	-0.9	-0.7	1.2	-1.7	2.8	2.9	3.0
Medication: Amlodipine	2.4	3.4	9.6	-0.7	-0.8	-0.2	0.7	-1.5	2.3	2.9	3.1
Medication: Ventolin 100micrograms inhaler	1.5	1.9	3.5	0.8	1.7	0.3	-1.9	1.5	-1.0	-1.4	-1.7
Birth weight	1.3	2.8	10.0	-1.0	-0.4	-3.2	-0.6	0.1	-2.0	-1.8	-1.8
Chronic bronchitis/emphysema (mother)	1.6	1.9	4.3	2.0	1.6	0.3	-2.1	1.9	-0.2	-0.4	-0.7
High blood pressure (siblings)	0.7	1.0	1.9	0.4	-1.1	-0.5	1.2	-1.1	0.5	1.4	1.4
Forced vital capacity (FVC), Best measure	0.6	2.1	4.1	-1.7	-1.9	-0.5	2.0	-0.9	-1.2	-1.4	-1.3
Body fat percentage	2.3	9.1	21.1	3.1	4.0	4.2	-2.3	4.6	0.1	-1.2	-1.4
Leg fat percentage (right)	1.1	4.0	10.1	1.9	2.6	3.2	-1.3	3.0	0.6	-0.5	-0.6
Arm fat-free mass (right)	0.8	4.2	11.9	-1.9	-3.5	-1.6	2.2	-2.5	-1.3	-1.2	-0.9
Exposure to tobacco smoke outside home	0.5	0.6	1.8	0.2	-1.3	-1.3	0.5	-0.7	-0.7	-0.3	-0.4
Comparative body size at age 10	1.6	4.4	13.5	3.7	1.8	2.3	-1.2	2.5	-0.8	-1.7	-1.4
Number of full brothers	2.6	3.3	5.8	-1.5	-1.6	-2.0	2.4	-2.0	0.9	1.9	1.8
Worry too long after embarrassment	10.1	16.9	40.7	2.8	6.1	3.1	-5.6	6.4	-0.4	-2.0	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.4	3.2	6.2	1.3	2.4	1.4	-2.4	2.5	-0.5	-1.4	-1.3
Wheeze or whistling in the chest in last year	1.2	2.2	3.8	-0.7	1.2	0.8	-1.7	1.3	-1.7	-1.9	-1.9
Number of children fathered	0.8	0.9	2.2	-1.4	-1.2	-0.4	0.9	-1.5	0.5	0.6	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	2.3	1.5	0.6	0.2	-0.7	0.7	-0.1	-0.4	-0.4
Age at first live birth	0.7	1.3	2.1	-0.3	-1.5	-1.1	0.1	-1.1	-1.4	-1.3	-1.4
Pulse wave peak to peak time	0.3	0.3	0.7	-0.8	0.9	0.7	-0.6	0.5	0.1	-0.0	-0.2
Health satisfaction	0.5	0.6	4.6	0.6	0.4	2.1	0.0	0.1	0.1	0.2	0.1
Shortness of breath walking on level ground	4.2	5.0	8.8	3.0	1.9	1.4	-1.6	2.6	-1.9	-2.4	-2.6
Qualifications: College or University degree	2.5	8.0	20.5	-1.6	-4.5	-2.8	3.6	-4.2	-1.4	-0.6	-0.6
Eye problems/disorders: None of the above	0.3	0.4	1.0	0.8	0.6	1.0	-0.2	0.5	-0.1	-0.5	-0.5
Mouth/teeth dental problems: Loose teeth	1.6	2.0	5.7	1.3	2.0	1.3	-2.4	1.6	0.1	-0.1	-0.2
Emphysema/chronic bronchitis	0.4	0.5	1.3	0.2	-1.0	-0.5	0.5	-1.1	-0.6	-0.7	-0.4
Medication for pain relief, constipation, heartburn	1.9	3.2	6.4	-2.0	-1.6	-1.0	0.6	-2.5	1.6	2.0	2.2
Neck or shoulder pain in last month	0.7	1.0	2.3	1.0	1.1	1.5	-1.1	0.6	0.9	0.8	0.6
Medication: Blood pressure	0.6	1.0	4.0	2.0	0.6	1.0	-0.4	1.4	-0.6	-0.5	-0.5
Angina (self-reported)	1.1	1.5	3.6	-0.8	-1.9	-0.6	1.0	-1.9	0.6	1.1	1.1
Migraine (self-reported)	1.5	1.9	3.6	0.5	1.6	0.2	-1.0	1.7	-1.3	-1.9	-1.7
Medication: Ibuprofen	0.4	0.4	0.8	-0.7	0.7	0.6	-0.2	0.8	-0.5	-0.6	-0.9
Medication: Allopurinol	0.9	1.3	4.3	1.4	0.3	2.1	0.1	1.3	-0.4	-0.9	-1.0
Medication: Omeprazole	0.5	0.6	1.3	0.1	0.4	1.0	-0.4	0.8	-0.7	-1.1	-1.0
Medication: Seretide 50 evohaler	3.1	3.6	8.3	1.9	2.9	2.3	-1.9	2.7	0.2	-0.5	-0.7
Mean time to correctly identify matches	1.0	1.9	5.8	0.4	2.4	-0.1	-1.4	2.0	1.0	1.1	0.8
Heart disease (mother)	3.3	4.0	9.7	-1.0	-2.4	-2.5	1.4	-3.1	0.8	1.8	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	3.3	1.8	-1.2	-1.4	1.0	-0.3	-0.1	0.1	-0.2
Whole body fat mass	1.1	4.6	10.4	2.3	2.2	2.8	-1.3	3.2	-0.7	-1.8	-1.8
Leg fat mass (right)	0.7	2.8	6.7	1.6	1.7	2.4	-0.9	2.6	-0.4	-1.4	-1.4
Arm predicted mass (right)	0.7	3.6	10.0	-1.9	-3.2	-1.4	2.1	-2.3	-1.2	-1.2	-1.0
Pulse rate, automated reading	3.4	11.0	27.8	2.1	5.3	3.5	-4.2	4.8	0.7	-0.9	-0.8
Alcohol intake frequency.	4.3	9.9	24.7	2.5	5.0	3.2	-4.4	4.2	0.8	-0.6	-0.7
Comparative height size at age 10	0.3	1.8	3.2	-1.4	-1.4	-0.8	0.5	-0.8	-1.7	-1.7	-1.8
Number of full sisters	1.0	1.3	2.0	-0.9	-0.9	-0.7	1.4	-1.3	1.0	1.4	1.1
Suffer from ‘nerves’	1.1	1.7	4.6	1.0	1.8	0.6	-1.6	2.1	-0.3	-0.8	-0.9
Overall health rating	4.3	9.2	19.0	2.3	4.3	4.4	-3.6	3.4	2.1	1.1	0.9
Chest pain or discomfort	0.4	0.6	2.6	-0.7	-0.9	-1.6	-0.1	-1.0	0.3	0.2	0.5
Had major operations	1.6	1.9	5.9	2.4	-0.2	1.0	0.5	0.9	-1.4	-1.6	-1.5
Age at last live birth	0.8	1.2	2.5	0.3	1.6	1.5	-1.5	1.4	0.1	-0.3	-0.5
Family relationship satisfaction	0.6	0.7	1.6	-0.2	0.6	-0.2	0.7	0.2	1.2	1.3	1.2
Leg pain on walking	1.5	1.9	6.0	-0.3	-2.1	-0.4	2.5	-1.3	-1.3	-0.8	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.9	-1.0	0.5	0.0	-0.1	0.7	-0.1	-0.2	-0.1
Commuting to job workplace: Car/motor vehicle	1.6	1.8	5.0	0.5	2.1	-0.7	-2.2	1.8	-0.2	-0.7	-0.9
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.5	-1.6	-0.9	-0.7	0.8	-1.2	0.8	1.1	0.9
Medication: Aspirin	0.5	0.6	1.3	0.3	0.6	0.7	0.2	0.7	1.1	1.2	1.1
Supplements: Vitamin C	1.3	1.5	3.1	1.0	1.2	-0.4	-1.0	1.8	-1.0	-1.4	-1.5
Knee pain experienced in last month	0.4	0.6	1.7	0.1	-0.0	1.0	1.3	0.8	-0.5	-0.6	-0.7
Hypertension (Self-reported)	1.1	2.9	5.9	1.8	-0.6	2.3	0.7	-0.3	1.9	2.1	2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.3	-1.1	-0.2	0.4	-1.1	0.5	-0.7	-0.8	-0.5
Illnesses of father: Heart disease	1.0	1.4	3.5	0.0	-0.7	-0.6	1.2	-0.7	1.5	1.6	1.9
Illnesses of siblings: Diabetes	0.1	0.2	0.5	0.2	0.4	0.3	-0.3	0.7	-0.2	-0.5	-0.3
Smoking status: Previous	0.7	1.0	2.2	-1.1	0.0	-0.7	-0.4	-0.6	1.3	1.4	1.5
Forced expiratory volume in 1-second (FEV1), predicted	2.6	5.5	12.1	-0.8	-2.0	-3.1	1.0	-1.0	-3.5	-2.6	-2.9
Whole body fat-free mass	0.7	4.3	9.1	-1.4	-3.0	-1.5	1.9	-1.7	-2.3	-2.2	-2.0
Leg fat-free mass (right)	0.4	2.1	5.2	-0.2	-1.3	-0.4	0.8	-0.0	-2.1	-2.3	-2.2
Arm fat percentage (left)	2.5	10.1	24.7	3.3	4.2	4.2	-2.4	5.0	-0.0	-1.4	-1.6
Average weekly red wine intake	9.9	14.7	39.6	-1.9	-6.3	-3.9	5.6	-5.1	-1.3	0.1	0.3
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.8	0.1	0.6	-0.8	-0.5	0.9	-0.5	-0.4	-0.5
Mood swings	3.7	6.7	13.9	2.9	3.1	2.3	-2.8	3.7	-1.1	-1.8	-2.0
Loneliness, isolation	4.5	6.2	14.0	2.5	3.7	1.8	-3.6	3.5	0.0	-0.7	-0.9
Long-standing illness, disability or infirmity	0.2	0.2	1.2	1.1	0.1	0.5	-0.6	0.0	-0.2	0.2	0.1
Ever had bowel cancer screening	1.0	1.2	2.1	0.1	-1.0	-0.8	1.0	-1.4	1.1	1.3	1.4
Diabetes diagnosed by doctor	0.8	1.2	2.9	0.6	0.4	0.9	-0.5	0.5	1.5	1.7	1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.7	-0.3	-0.6	-0.5	0.8	0.2	-0.6	-0.6	-0.7
Friendships satisfaction	0.3	0.4	1.6	-0.7	0.5	1.2	-0.3	0.2	0.5	0.3	0.4
Qualifications: nursing, teaching	2.9	4.4	14.6	-0.2	-3.8	-2.2	2.1	-2.7	-1.6	-1.1	-0.9
Commuting to job workplace: Walk	0.7	0.8	2.7	0.1	-1.6	-1.1	0.6	-1.3	-0.3	0.1	0.0
Eye problems/disorders: Cataract	0.1	0.1	0.3	0.6	-0.0	-0.1	-0.1	-0.0	0.3	0.5	0.4
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.6	0.8	0.6	0.5	-0.3	1.0	-1.1	-1.5	-1.6
Medication for cholesterol	2.0	3.0	7.8	1.0	0.7	-0.6	-1.3	0.8	-2.4	-2.6	-2.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	1.0	0.4	-0.0	-0.6	-1.0	-0.2	0.2	0.2	0.1
Back pain experienced in last month	0.4	0.6	1.5	-0.2	0.5	1.2	-0.9	1.0	-0.3	-0.8	-0.8
Mineral and other dietary supplements	2.7	3.6	7.0	1.3	2.6	2.1	-1.5	2.0	2.2	1.6	1.5
Breast cancer (self-reported)	0.8	0.9	3.2	0.9	1.5	0.8	-0.5	1.8	0.4	-0.4	-0.2
Asthma (self-reported)	1.7	3.4	6.4	-0.5	1.6	1.4	-1.9	1.8	-1.9	-2.5	-2.5
Osteoporosis (self-reported)	1.4	1.7	5.0	0.7	-0.4	2.2	0.5	-0.9	1.8	1.3	1.4
Osteoarthritis (self-reported)	0.2	0.3	0.5	0.7	0.2	0.7	0.6	0.7	-0.4	-0.5	-0.3
Medication: Aspirin	0.3	0.4	1.2	-0.1	0.0	0.2	0.4	0.0	0.9	1.1	1.1
Medication: Gliclazide	0.4	0.4	2.1	1.4	-0.0	0.3	-0.7	-0.1	0.5	0.5	0.6
Illnesses of father: None of the above (group 1)	0.7	0.8	1.7	-0.2	0.7	-0.7	-0.8	0.6	-1.3	-1.1	-1.3
Smoking status: Current	2.3	3.6	9.5	-0.1	2.7	1.6	-2.4	3.1	-0.5	-1.3	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.7	23.6	-0.0	-3.0	-1.1	4.9	-1.9	-0.4	-0.2	-0.1
Whole body water mass	0.7	3.8	8.0	-1.3	-2.8	-1.3	1.8	-1.6	-2.2	-2.2	-1.9
Leg predicted mass (right)	0.4	2.3	5.7	-0.2	-1.3	-0.4	0.8	0.0	-2.2	-2.4	-2.3
Arm fat mass (left)	1.3	5.4	12.5	2.3	2.6	3.0	-1.6	3.5	-0.7	-1.8	-1.9
Number of self-reported non-cancer illnesses	0.4	0.8	2.3	-0.7	-0.2	0.5	0.3	-0.4	1.1	1.3	1.5
Average weekly champagne plus white wine intake	0.1	0.1	0.3	0.2	-0.5	-0.1	0.5	-0.5	-0.2	-0.3	-0.2
Miserableness	1.8	3.2	6.4	1.3	2.4	1.9	-2.1	2.5	-0.8	-1.1	-1.4
Guilty feelings	9.7	14.6	32.8	2.8	5.1	2.9	-5.1	5.7	-1.4	-2.6	-2.7
Wears glasses or contact lenses	2.8	3.3	7.9	-1.4	-2.8	-1.7	2.1	-2.3	-1.4	-0.8	-1.1
Ever taken oral contraceptive pill	2.8	3.1	10.3	-3.2	-2.1	-2.0	1.4	-1.7	-1.0	-0.4	-0.3
Hearing aid user	1.3	1.5	5.1	0.7	-2.3	-0.9	1.3	-1.7	-0.9	-0.3	-0.2
Mother’s age at death	0.6	0.8	1.5	-1.1	-0.1	0.7	0.6	0.7	-1.0	-1.2	-1.2
Financial situation satisfaction	1.0	1.2	4.2	0.5	2.0	0.9	-0.1	2.1	0.5	0.5	0.2
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.3	0.8	1.5	1.0	-1.3	1.2	0.6	0.8	0.7
Commuting to job workplace: Public transport	1.0	1.2	3.9	-0.2	-2.0	-0.7	1.7	-1.4	-0.6	0.2	0.3
Eye problems/disorders: Glaucoma	3.1	3.6	6.4	-2.2	-2.5	-2.5	1.6	-1.9	-1.7	-1.3	-1.0
Medication: Blood pressure	1.9	3.7	9.2	-0.2	-1.4	0.6	1.3	-1.8	2.3	2.7	3.0
Pain type(s) experienced in last month: Hip pain	1.3	1.7	5.9	0.5	0.6	2.4	-0.4	1.3	-0.8	-1.6	-1.5
Supplements: Fish oil (including cod liver oil)	2.4	3.1	7.4	-1.3	-2.5	-2.7	1.9	-2.1	-1.0	-0.6	-0.4
High cholesterol (Self-reported)	0.8	1.5	3.5	0.9	0.8	0.7	0.4	0.7	1.9	1.6	1.9
Medication: Bendroflumethiazide	0.3	0.5	1.7	0.4	-1.3	0.5	0.6	-1.1	0.2	0.3	0.7
Medication: Paracetamol	3.9	6.0	9.9	2.3	2.6	2.1	-2.1	3.1	-1.8	-2.7	-2.6
Medication: Lisinopril	0.4	0.5	2.1	0.8	-0.8	-0.4	1.4	-0.3	0.0	-0.0	0.1
Medication: Atorvastatin	1.8	2.3	5.2	-1.1	-0.7	-0.0	1.4	-0.6	2.2	2.1	2.3
Illnesses of father: High blood pressure	1.7	2.1	3.9	0.1	-1.6	0.6	2.0	-1.6	1.6	1.4	1.8
Alcohol drinker status: Never	3.2	3.9	6.3	2.1	1.8	2.5	-1.7	2.5	-0.8	-1.9	-1.8
Ever smoked	0.9	1.5	4.0	-1.6	1.5	0.7	-2.0	1.4	-0.3	-0.7	-0.6
Basal metabolic rate	0.6	3.1	6.2	-0.7	-2.1	-0.7	1.3	-0.7	-2.3	-2.5	-2.3
Leg fat percentage (left)	1.2	4.2	10.3	1.9	2.7	3.2	-1.4	3.1	0.5	-0.5	-0.6
Arm fat-free mass (left)	0.6	3.1	8.2	-1.2	-2.9	-1.3	1.9	-1.8	-1.6	-1.4	-1.3
Number of operations (self-reported)	1.5	2.2	4.5	-0.1	-1.9	-1.1	2.1	-0.8	-1.8	-1.6	-1.5
Average weekly beer plus cider intake	1.2	1.7	3.6	-1.1	-1.2	-0.6	0.5	-1.9	1.3	1.5	1.8
Irritability	4.5	7.6	16.4	2.6	3.3	2.0	-4.0	3.6	-1.2	-1.9	-2.1
Risk taking	1.5	2.2	5.2	-0.4	-0.6	-1.3	0.5	0.3	-2.3	-2.2	-2.2
Ever had prostate specific antigen (PSA) test	0.9	1.1	4.1	-0.3	-1.9	0.3	0.8	-2.0	-0.3	-0.1	-0.1
Fractured/broken bones in last 5 years	0.9	1.2	2.6	-1.6	-1.4	-0.7	1.3	-1.4	0.3	0.4	0.5
Age started oral contraceptive pill	1.0	1.2	2.6	-0.5	-1.1	-0.2	0.8	-0.9	-1.5	-1.6	-1.4
Diastolic blood pressure, automated reading	1.6	4.8	13.3	0.7	-0.7	0.9	1.5	-1.0	3.1	3.3	3.6
Ever depressed for a whole week	1.1	1.3	3.1	-0.0	1.8	0.2	-1.3	1.4	1.1	1.1	1.1
Unable to work because of sickness or disability	5.5	7.1	13.8	2.4	3.7	3.1	-3.3	3.7	-0.1	-1.1	-1.2
Commuting to job workplace: Cycle	2.3	2.8	8.5	-1.0	-2.6	-0.3	2.1	-2.9	0.4	0.7	1.0
Myopia	0.2	0.4	1.1	-0.8	0.7	1.0	-0.5	0.5	-0.0	-0.3	-0.3
Vascular/heart problems diagnosed by doctor	1.2	3.3	7.0	-1.4	0.6	-2.3	-1.2	0.2	-2.2	-2.4	-2.6
Cholesterol lowering medication	1.4	2.0	4.8	0.4	1.1	0.8	-0.2	0.7	2.2	2.0	2.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	1.6	0.3	0.4	1.3	-0.9	0.6	-0.1	-0.6	-0.3
Pain experienced in last month	3.4	5.6	12.0	-2.3	-3.2	-2.8	2.5	-3.5	0.4	1.1	1.4
Supplements: Calcium	0.2	0.2	0.5	-0.7	-0.2	-0.3	-0.3	-0.2	0.4	0.6	0.5
Basal cell carcinoma (self-reported)	0.3	0.3	0.6	-0.4	-0.1	0.4	0.4	-0.8	0.8	0.6	0.6
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.4	-0.7	-0.2	-0.3	-0.6	-0.7	1.1	0.9	1.2
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	4.5	2.1	1.2	0.8	-0.5	1.4	-0.5	-0.7	-1.1
Heart disease (siblings)	1.6	2.0	5.6	-0.6	0.4	0.5	-0.2	-0.9	2.0	2.2	2.4
Alcohol drinker status: Previous	4.9	5.6	9.9	2.6	3.1	1.4	-2.9	3.1	-1.2	-1.7	-2.1
Pack years of smoking	2.9	4.3	9.7	1.8	3.1	2.7	-2.1	3.0	0.1	-0.4	-0.7
Impedance of whole body	0.7	3.8	7.2	1.2	2.6	1.6	-2.2	2.7	-1.1	-1.5	-1.9
Leg fat mass (left)	0.7	2.8	6.8	1.6	1.7	2.4	-1.0	2.6	-0.4	-1.3	-1.4
Arm predicted mass (left)	0.5	2.4	6.7	-1.2	-2.6	-1.0	1.5	-1.6	-1.4	-1.3	-1.1