[Hub]/) : Traits : Blood Eosinophil Count :

chr11:60,173,360-62,605,067

Best TWAS P=1.21e-31 · Best GWAS P=6.36e-31 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FADS1 0.14 0.16 lasso 2 0.16 7.2e-19 -11.3 11.3 1.6e-29 -0.96 0.02 0.98 FALSE
2 CommonMind Brain Pre-frontal Cortex FEN1 0.07 0.06 lasso 4 0.06 1.1e-07 -11.3 -11.3 2.3e-29 0.96 0.03 0.97 FALSE
3 GTEx Adrenal Gland INCENP 0.23 0.05 lasso 3 0.03 3.8e-02 6.5 6.8 9.5e-12 -0.43 0.08 0.07 FALSE
4 GTEx Artery Aorta FADS2 0.18 0.17 lasso 3 0.14 3.2e-08 -6.3 -7.5 6.7e-14 0.69 0.26 0.74 FALSE
5 GTEx Artery Tibial FADS2 0.08 0.02 lasso 4 0.02 6.9e-03 -10.4 -10.5 7.1e-26 0.79 0.02 0.95 FALSE
6 GTEx Artery Tibial TMEM258 0.08 0.05 lasso 5 0.02 1.1e-02 -11.5 -11.6 2.5e-31 0.97 0.01 0.99 FALSE
7 GTEx Brain Cerebellum FADS1 0.35 0.24 enet 16 0.30 2.1e-09 -11.1 11.4 5.8e-30 -0.90 0.04 0.96 FALSE
8 GTEx Brain Cerebellum FADS3 0.26 0.18 lasso 4 0.14 5.7e-05 -11.2 11.5 2.0e-30 -0.91 0.02 0.88 FALSE
9 GTEx Brain Putamen basal ganglia FADS1 0.29 0.21 enet 30 0.16 1.4e-04 -11.3 9.8 7.4e-23 -0.78 0.03 0.88 FALSE
10 GTEx Breast Mammary Tissue (Female) TMEM258 0.20 0.02 lasso 7 0.00 2.3e-01 -7.1 -9.0 3.1e-19 0.78 0.04 0.52 FALSE
11 GTEx Cells Transformed fibroblasts FADS2 0.20 0.23 lasso 3 0.23 4.6e-17 -6.3 -6.5 7.2e-11 0.60 1.00 0.00 FALSE
12 GTEx Cells Transformed fibroblasts TMEM258 0.15 0.05 enet 15 0.07 1.1e-05 -10.4 -9.9 5.6e-23 0.77 0.10 0.89 FALSE
13 GTEx Colon Sigmoid FADS2 0.24 0.12 lasso 5 0.13 2.2e-05 -4.3 -6.1 8.2e-10 0.55 0.08 0.78 FALSE
14 GTEx Colon Transverse FADS2 0.18 0.11 lasso 7 0.16 8.1e-08 -6.3 -9.2 3.2e-20 0.75 0.08 0.92 FALSE
15 GTEx Esophagus Gastroesophageal Junction FADS2 0.22 0.22 lasso 2 0.20 7.8e-08 -6.3 -6.3 3.5e-10 0.57 0.34 0.56 FALSE
16 GTEx Esophagus Mucosa FADS1 0.11 0.00 lasso 4 0.02 1.9e-02 -10.7 10.6 2.0e-26 -0.85 0.03 0.91 TRUE
17 GTEx Esophagus Muscularis FADS2 0.32 0.30 lasso 6 0.31 3.7e-19 -6.3 -7.8 9.2e-15 0.70 0.99 0.01 FALSE
18 GTEx Heart Atrial Appendage FADS2 0.16 0.11 lasso 1 0.04 5.1e-03 -6.3 -6.3 2.7e-10 0.58 0.11 0.76 FALSE
19 GTEx Heart Left Ventricle FADS2 0.17 0.12 enet 3 0.13 1.5e-07 -7.2 -7.9 3.0e-15 0.72 0.24 0.76 FALSE
20 GTEx Muscle Skeletal FADS2 0.08 0.04 lasso 2 0.03 5.9e-04 -11.6 -10.7 1.5e-26 0.94 0.01 0.99 FALSE
21 GTEx Nerve Tibial DAGLA 0.13 0.07 lasso 4 0.06 7.6e-05 6.2 -6.2 5.3e-10 0.28 0.18 0.03 FALSE
22 GTEx Nerve Tibial FADS2 0.20 0.14 lasso 3 0.13 1.5e-09 -6.3 -6.5 8.7e-11 0.60 0.84 0.16 FALSE
23 GTEx Pancreas FADS1 0.17 0.13 lasso 6 0.12 1.2e-05 -11.2 11.6 4.7e-31 -0.91 0.03 0.97 FALSE
24 GTEx Spleen MYRF 0.23 0.00 lasso 4 -0.01 4.6e-01 -6.5 -7.4 1.4e-13 0.52 0.04 0.33 TRUE
25 GTEx Spleen FADS2 0.30 0.27 lasso 3 0.27 1.6e-07 -6.3 -8.0 1.9e-15 0.71 0.08 0.90 FALSE
26 GTEx Testis DAGLA 0.26 0.16 enet 11 0.09 1.1e-04 6.2 -5.9 4.4e-09 0.27 0.54 0.04 FALSE
27 GTEx Thyroid FADS2 0.16 0.18 lasso 4 0.17 7.0e-13 -6.3 -6.4 1.4e-10 0.59 1.00 0.00 FALSE
28 GTEx Uterus PPP1R32 0.66 -0.01 lasso 13 0.14 8.8e-04 -2.7 -9.2 2.7e-20 0.58 0.02 0.49 FALSE
29 GTEx Whole Blood MYRF 0.17 0.03 lasso 5 0.04 2.4e-04 6.2 -5.1 2.7e-07 0.18 0.53 0.02 FALSE
30 GTEx Whole Blood FADS2 0.49 0.48 lasso 5 0.48 3.0e-49 -6.3 -6.6 4.7e-11 0.60 1.00 0.00 FALSE
31 METSIM Adipose FADS2 0.07 0.05 lasso 3 0.04 3.2e-07 -6.3 -5.6 1.9e-08 0.55 0.97 0.01 TRUE
32 METSIM Adipose MYRF 0.08 0.06 lasso 1 0.06 2.4e-09 6.1 -6.1 1.3e-09 0.31 1.00 0.00 FALSE
33 METSIM Adipose TMEM258 0.04 0.00 bslmm 407 0.01 4.1e-02 -11.2 -5.6 2.2e-08 0.65 0.02 0.89 FALSE
34 NTR Blood C11orf10 0.06 0.08 bslmm 399 0.08 1.3e-24 -10.4 -10.5 1.3e-25 0.91 0.08 0.92 FALSE
35 NTR Blood FADS2 0.30 0.33 lasso 7 0.33 9.0e-109 -6.3 -6.9 4.7e-12 0.63 1.00 0.00 FALSE
36 ROSMAP Brain Pre-frontal Cortex TMEM258 0.14 0.16 lasso 4 0.15 4.7e-19 -10.4 -10.8 5.4e-27 0.92 0.11 0.89 FALSE
37 ROSMAP Brain Pre-frontal Cortex FADS1 0.08 0.08 enet 10 0.09 1.5e-11 -11.5 11.6 6.0e-31 -0.95 0.01 0.99 FALSE
38 YFS Blood CD5 0.06 0.01 enet 21 0.04 2.3e-13 -5.0 -7.8 7.5e-15 0.13 0.86 0.14 TRUE
39 YFS Blood FADS1 0.11 0.08 lasso 8 0.09 6.1e-29 -6.3 -9.0 2.1e-19 0.76 1.00 0.00 FALSE
40 The Cancer Genome Atlas Breast Invasive Carcinoma FADS1 0.04 0.00 blup 53 0.01 1.4e-03 -2.5 7.3 2.0e-13 -0.62 0.02 0.38 FALSE
41 The Cancer Genome Atlas Breast Invasive Carcinoma FADS2 0.05 0.04 lasso 2 0.04 2.2e-09 -6.3 -6.1 1.2e-09 0.56 0.98 0.02 FALSE
42 The Cancer Genome Atlas Breast Invasive Carcinoma RPLP0P2 0.03 0.04 enet 4 0.04 2.2e-08 5.7 6.0 2.0e-09 -0.11 0.05 0.95 TRUE
43 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma FADS1 0.06 0.03 lasso 4 0.04 7.4e-03 -11.2 10.6 4.1e-26 -0.81 0.02 0.70 FALSE
44 The Cancer Genome Atlas Colon Adenocarcinoma FADS2 0.30 0.21 lasso 2 0.22 6.7e-13 -6.3 -8.4 5.6e-17 0.75 0.67 0.33 FALSE
45 The Cancer Genome Atlas Colon Adenocarcinoma RPLP0P2 0.10 0.06 blup 30 0.07 5.6e-05 5.7 5.6 2.1e-08 -0.09 0.02 0.70 FALSE
46 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma FADS2 0.05 0.04 lasso 3 0.05 1.9e-06 -6.3 -7.3 3.1e-13 0.70 0.25 0.69 FALSE
47 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma FADS2 0.26 0.29 enet 15 0.29 2.9e-33 -6.3 -8.2 1.8e-16 0.72 1.00 0.00 FALSE
48 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FADS2 0.33 0.27 lasso 9 0.35 9.3e-21 -6.3 -9.2 4.7e-20 0.78 0.64 0.36 FALSE
49 The Cancer Genome Atlas Brain Lower Grade Glioma FADS1 0.05 0.05 blup 53 0.04 6.8e-05 -9.9 10.3 1.0e-24 -0.86 0.04 0.96 FALSE
50 The Cancer Genome Atlas Liver Hepatocellular Carcinoma FADS1 0.20 0.01 blup 51 0.07 3.2e-04 -11.4 10.3 7.1e-25 -0.85 0.01 0.94 FALSE
51 The Cancer Genome Atlas Lung Adenocarcinoma FADS2 0.04 0.04 lasso 4 0.02 1.7e-03 -6.3 -6.8 1.5e-11 0.62 0.07 0.75 FALSE
52 The Cancer Genome Atlas Lung Squamous Cell Carcinoma FADS2 0.02 0.01 blup 71 0.02 1.9e-03 -11.6 -10.2 2.2e-24 0.90 0.02 0.85 FALSE
53 The Cancer Genome Atlas Lung Squamous Cell Carcinoma RPLP0P2 0.03 0.04 lasso 2 0.03 3.2e-04 5.7 5.7 1.3e-08 -0.08 0.04 0.88 FALSE
54 The Cancer Genome Atlas Pancreatic Adenocarcinoma FADS2 0.15 0.16 lasso 2 0.12 8.8e-06 -6.3 -6.7 1.6e-11 0.60 0.41 0.40 FALSE
55 The Cancer Genome Atlas Prostate Adenocarcinoma C11orf10 0.02 0.01 enet 11 0.01 1.6e-02 -10.4 -8.6 1.2e-17 0.77 0.01 0.76 TRUE
56 The Cancer Genome Atlas Prostate Adenocarcinoma FADS1 0.06 0.04 blup 53 0.03 2.0e-04 -11.1 9.8 1.3e-22 -0.68 0.06 0.55 FALSE
57 The Cancer Genome Atlas Prostate Adenocarcinoma FADS2 0.07 0.07 lasso 4 0.06 1.9e-06 -6.3 -7.5 4.5e-14 0.69 0.12 0.86 FALSE
58 The Cancer Genome Atlas Rectum Adenocarcinoma FADS2 0.47 0.34 lasso 5 0.30 7.9e-08 -6.3 -7.6 3.1e-14 0.68 0.04 0.94 FALSE
59 The Cancer Genome Atlas Soft Tissue Sarcoma C11orf9 0.08 0.01 enet 11 0.03 1.0e-02 -4.5 -6.1 8.6e-10 0.23 0.04 0.04 FALSE
60 The Cancer Genome Atlas Stomach Adenocarcinoma FADS2 0.15 0.05 blup 71 0.11 2.5e-08 -6.3 -7.3 1.9e-13 0.71 0.04 0.95 TRUE
61 The Cancer Genome Atlas Thyroid Carcinoma C11orf10 0.02 0.02 blup 44 0.02 1.8e-03 -10.0 -11.7 1.2e-31 0.95 0.02 0.70 TRUE
62 The Cancer Genome Atlas Thyroid Carcinoma FADS2 0.30 0.33 lasso 8 0.33 5.6e-33 -6.3 -7.9 3.1e-15 0.71 1.00 0.00 FALSE