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chr11:60,173,360-62,605,067

Best TWAS P=1.21e-31 · Best GWAS P=6.36e-31 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FADS1	0.14	0.16	lasso	2	0.16	7.2e-19	-11.3	11.3	1.6e-29	-0.96	0.02	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FEN1	0.07	0.06	lasso	4	0.06	1.1e-07	-11.3	-11.3	2.3e-29	0.96	0.03	0.97	FALSE
3	GTEx	Adrenal Gland	INCENP	0.23	0.05	lasso	3	0.03	3.8e-02	6.5	6.8	9.5e-12	-0.43	0.08	0.07	FALSE
4	GTEx	Artery Aorta	FADS2	0.18	0.17	lasso	3	0.14	3.2e-08	-6.3	-7.5	6.7e-14	0.69	0.26	0.74	FALSE
5	GTEx	Artery Tibial	FADS2	0.08	0.02	lasso	4	0.02	6.9e-03	-10.4	-10.5	7.1e-26	0.79	0.02	0.95	FALSE
6	GTEx	Artery Tibial	TMEM258	0.08	0.05	lasso	5	0.02	1.1e-02	-11.5	-11.6	2.5e-31	0.97	0.01	0.99	FALSE
7	GTEx	Brain Cerebellum	FADS1	0.35	0.24	enet	16	0.30	2.1e-09	-11.1	11.4	5.8e-30	-0.90	0.04	0.96	FALSE
8	GTEx	Brain Cerebellum	FADS3	0.26	0.18	lasso	4	0.14	5.7e-05	-11.2	11.5	2.0e-30	-0.91	0.02	0.88	FALSE
9	GTEx	Brain Putamen basal ganglia	FADS1	0.29	0.21	enet	30	0.16	1.4e-04	-11.3	9.8	7.4e-23	-0.78	0.03	0.88	FALSE
10	GTEx	Breast Mammary Tissue (Female)	TMEM258	0.20	0.02	lasso	7	0.00	2.3e-01	-7.1	-9.0	3.1e-19	0.78	0.04	0.52	FALSE
11	GTEx	Cells Transformed fibroblasts	FADS2	0.20	0.23	lasso	3	0.23	4.6e-17	-6.3	-6.5	7.2e-11	0.60	1.00	0.00	FALSE
12	GTEx	Cells Transformed fibroblasts	TMEM258	0.15	0.05	enet	15	0.07	1.1e-05	-10.4	-9.9	5.6e-23	0.77	0.10	0.89	FALSE
13	GTEx	Colon Sigmoid	FADS2	0.24	0.12	lasso	5	0.13	2.2e-05	-4.3	-6.1	8.2e-10	0.55	0.08	0.78	FALSE
14	GTEx	Colon Transverse	FADS2	0.18	0.11	lasso	7	0.16	8.1e-08	-6.3	-9.2	3.2e-20	0.75	0.08	0.92	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	FADS2	0.22	0.22	lasso	2	0.20	7.8e-08	-6.3	-6.3	3.5e-10	0.57	0.34	0.56	FALSE
16	GTEx	Esophagus Mucosa	FADS1	0.11	0.00	lasso	4	0.02	1.9e-02	-10.7	10.6	2.0e-26	-0.85	0.03	0.91	TRUE
17	GTEx	Esophagus Muscularis	FADS2	0.32	0.30	lasso	6	0.31	3.7e-19	-6.3	-7.8	9.2e-15	0.70	0.99	0.01	FALSE
18	GTEx	Heart Atrial Appendage	FADS2	0.16	0.11	lasso	1	0.04	5.1e-03	-6.3	-6.3	2.7e-10	0.58	0.11	0.76	FALSE
19	GTEx	Heart Left Ventricle	FADS2	0.17	0.12	enet	3	0.13	1.5e-07	-7.2	-7.9	3.0e-15	0.72	0.24	0.76	FALSE
20	GTEx	Muscle Skeletal	FADS2	0.08	0.04	lasso	2	0.03	5.9e-04	-11.6	-10.7	1.5e-26	0.94	0.01	0.99	FALSE
21	GTEx	Nerve Tibial	DAGLA	0.13	0.07	lasso	4	0.06	7.6e-05	6.2	-6.2	5.3e-10	0.28	0.18	0.03	FALSE
22	GTEx	Nerve Tibial	FADS2	0.20	0.14	lasso	3	0.13	1.5e-09	-6.3	-6.5	8.7e-11	0.60	0.84	0.16	FALSE
23	GTEx	Pancreas	FADS1	0.17	0.13	lasso	6	0.12	1.2e-05	-11.2	11.6	4.7e-31	-0.91	0.03	0.97	FALSE
24	GTEx	Spleen	MYRF	0.23	0.00	lasso	4	-0.01	4.6e-01	-6.5	-7.4	1.4e-13	0.52	0.04	0.33	TRUE
25	GTEx	Spleen	FADS2	0.30	0.27	lasso	3	0.27	1.6e-07	-6.3	-8.0	1.9e-15	0.71	0.08	0.90	FALSE
26	GTEx	Testis	DAGLA	0.26	0.16	enet	11	0.09	1.1e-04	6.2	-5.9	4.4e-09	0.27	0.54	0.04	FALSE
27	GTEx	Thyroid	FADS2	0.16	0.18	lasso	4	0.17	7.0e-13	-6.3	-6.4	1.4e-10	0.59	1.00	0.00	FALSE
28	GTEx	Uterus	PPP1R32	0.66	-0.01	lasso	13	0.14	8.8e-04	-2.7	-9.2	2.7e-20	0.58	0.02	0.49	FALSE
29	GTEx	Whole Blood	MYRF	0.17	0.03	lasso	5	0.04	2.4e-04	6.2	-5.1	2.7e-07	0.18	0.53	0.02	FALSE
30	GTEx	Whole Blood	FADS2	0.49	0.48	lasso	5	0.48	3.0e-49	-6.3	-6.6	4.7e-11	0.60	1.00	0.00	FALSE
31	METSIM	Adipose	FADS2	0.07	0.05	lasso	3	0.04	3.2e-07	-6.3	-5.6	1.9e-08	0.55	0.97	0.01	TRUE
32	METSIM	Adipose	MYRF	0.08	0.06	lasso	1	0.06	2.4e-09	6.1	-6.1	1.3e-09	0.31	1.00	0.00	FALSE
33	METSIM	Adipose	TMEM258	0.04	0.00	bslmm	407	0.01	4.1e-02	-11.2	-5.6	2.2e-08	0.65	0.02	0.89	FALSE
34	NTR	Blood	C11orf10	0.06	0.08	bslmm	399	0.08	1.3e-24	-10.4	-10.5	1.3e-25	0.91	0.08	0.92	FALSE
35	NTR	Blood	FADS2	0.30	0.33	lasso	7	0.33	9.0e-109	-6.3	-6.9	4.7e-12	0.63	1.00	0.00	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	TMEM258	0.14	0.16	lasso	4	0.15	4.7e-19	-10.4	-10.8	5.4e-27	0.92	0.11	0.89	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	FADS1	0.08	0.08	enet	10	0.09	1.5e-11	-11.5	11.6	6.0e-31	-0.95	0.01	0.99	FALSE
38	YFS	Blood	CD5	0.06	0.01	enet	21	0.04	2.3e-13	-5.0	-7.8	7.5e-15	0.13	0.86	0.14	TRUE
39	YFS	Blood	FADS1	0.11	0.08	lasso	8	0.09	6.1e-29	-6.3	-9.0	2.1e-19	0.76	1.00	0.00	FALSE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	FADS1	0.04	0.00	blup	53	0.01	1.4e-03	-2.5	7.3	2.0e-13	-0.62	0.02	0.38	FALSE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	FADS2	0.05	0.04	lasso	2	0.04	2.2e-09	-6.3	-6.1	1.2e-09	0.56	0.98	0.02	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPLP0P2	0.03	0.04	enet	4	0.04	2.2e-08	5.7	6.0	2.0e-09	-0.11	0.05	0.95	TRUE
43	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FADS1	0.06	0.03	lasso	4	0.04	7.4e-03	-11.2	10.6	4.1e-26	-0.81	0.02	0.70	FALSE
44	The Cancer Genome Atlas	Colon Adenocarcinoma	FADS2	0.30	0.21	lasso	2	0.22	6.7e-13	-6.3	-8.4	5.6e-17	0.75	0.67	0.33	FALSE
45	The Cancer Genome Atlas	Colon Adenocarcinoma	RPLP0P2	0.10	0.06	blup	30	0.07	5.6e-05	5.7	5.6	2.1e-08	-0.09	0.02	0.70	FALSE
46	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FADS2	0.05	0.04	lasso	3	0.05	1.9e-06	-6.3	-7.3	3.1e-13	0.70	0.25	0.69	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FADS2	0.26	0.29	enet	15	0.29	2.9e-33	-6.3	-8.2	1.8e-16	0.72	1.00	0.00	FALSE
48	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FADS2	0.33	0.27	lasso	9	0.35	9.3e-21	-6.3	-9.2	4.7e-20	0.78	0.64	0.36	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	FADS1	0.05	0.05	blup	53	0.04	6.8e-05	-9.9	10.3	1.0e-24	-0.86	0.04	0.96	FALSE
50	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	FADS1	0.20	0.01	blup	51	0.07	3.2e-04	-11.4	10.3	7.1e-25	-0.85	0.01	0.94	FALSE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	FADS2	0.04	0.04	lasso	4	0.02	1.7e-03	-6.3	-6.8	1.5e-11	0.62	0.07	0.75	FALSE
52	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FADS2	0.02	0.01	blup	71	0.02	1.9e-03	-11.6	-10.2	2.2e-24	0.90	0.02	0.85	FALSE
53	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RPLP0P2	0.03	0.04	lasso	2	0.03	3.2e-04	5.7	5.7	1.3e-08	-0.08	0.04	0.88	FALSE
54	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FADS2	0.15	0.16	lasso	2	0.12	8.8e-06	-6.3	-6.7	1.6e-11	0.60	0.41	0.40	FALSE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	C11orf10	0.02	0.01	enet	11	0.01	1.6e-02	-10.4	-8.6	1.2e-17	0.77	0.01	0.76	TRUE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	FADS1	0.06	0.04	blup	53	0.03	2.0e-04	-11.1	9.8	1.3e-22	-0.68	0.06	0.55	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	FADS2	0.07	0.07	lasso	4	0.06	1.9e-06	-6.3	-7.5	4.5e-14	0.69	0.12	0.86	FALSE
58	The Cancer Genome Atlas	Rectum Adenocarcinoma	FADS2	0.47	0.34	lasso	5	0.30	7.9e-08	-6.3	-7.6	3.1e-14	0.68	0.04	0.94	FALSE
59	The Cancer Genome Atlas	Soft Tissue Sarcoma	C11orf9	0.08	0.01	enet	11	0.03	1.0e-02	-4.5	-6.1	8.6e-10	0.23	0.04	0.04	FALSE
60	The Cancer Genome Atlas	Stomach Adenocarcinoma	FADS2	0.15	0.05	blup	71	0.11	2.5e-08	-6.3	-7.3	1.9e-13	0.71	0.04	0.95	TRUE
61	The Cancer Genome Atlas	Thyroid Carcinoma	C11orf10	0.02	0.02	blup	44	0.02	1.8e-03	-10.0	-11.7	1.2e-31	0.95	0.02	0.70	TRUE
62	The Cancer Genome Atlas	Thyroid Carcinoma	FADS2	0.30	0.33	lasso	8	0.33	5.6e-33	-6.3	-7.9	3.1e-15	0.71	1.00	0.00	FALSE