Best TWAS P=1.21e-31 · Best GWAS P=6.36e-31 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FADS1 | 0.14 | 0.16 | lasso | 2 | 0.16 | 7.2e-19 | -11.3 | 11.3 | 1.6e-29 | -0.96 | 0.02 | 0.98 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | FEN1 | 0.07 | 0.06 | lasso | 4 | 0.06 | 1.1e-07 | -11.3 | -11.3 | 2.3e-29 | 0.96 | 0.03 | 0.97 | FALSE |
3 | GTEx | Adrenal Gland | INCENP | 0.23 | 0.05 | lasso | 3 | 0.03 | 3.8e-02 | 6.5 | 6.8 | 9.5e-12 | -0.43 | 0.08 | 0.07 | FALSE |
4 | GTEx | Artery Aorta | FADS2 | 0.18 | 0.17 | lasso | 3 | 0.14 | 3.2e-08 | -6.3 | -7.5 | 6.7e-14 | 0.69 | 0.26 | 0.74 | FALSE |
5 | GTEx | Artery Tibial | FADS2 | 0.08 | 0.02 | lasso | 4 | 0.02 | 6.9e-03 | -10.4 | -10.5 | 7.1e-26 | 0.79 | 0.02 | 0.95 | FALSE |
6 | GTEx | Artery Tibial | TMEM258 | 0.08 | 0.05 | lasso | 5 | 0.02 | 1.1e-02 | -11.5 | -11.6 | 2.5e-31 | 0.97 | 0.01 | 0.99 | FALSE |
7 | GTEx | Brain Cerebellum | FADS1 | 0.35 | 0.24 | enet | 16 | 0.30 | 2.1e-09 | -11.1 | 11.4 | 5.8e-30 | -0.90 | 0.04 | 0.96 | FALSE |
8 | GTEx | Brain Cerebellum | FADS3 | 0.26 | 0.18 | lasso | 4 | 0.14 | 5.7e-05 | -11.2 | 11.5 | 2.0e-30 | -0.91 | 0.02 | 0.88 | FALSE |
9 | GTEx | Brain Putamen basal ganglia | FADS1 | 0.29 | 0.21 | enet | 30 | 0.16 | 1.4e-04 | -11.3 | 9.8 | 7.4e-23 | -0.78 | 0.03 | 0.88 | FALSE |
10 | GTEx | Breast Mammary Tissue (Female) | TMEM258 | 0.20 | 0.02 | lasso | 7 | 0.00 | 2.3e-01 | -7.1 | -9.0 | 3.1e-19 | 0.78 | 0.04 | 0.52 | FALSE |
11 | GTEx | Cells Transformed fibroblasts | FADS2 | 0.20 | 0.23 | lasso | 3 | 0.23 | 4.6e-17 | -6.3 | -6.5 | 7.2e-11 | 0.60 | 1.00 | 0.00 | FALSE |
12 | GTEx | Cells Transformed fibroblasts | TMEM258 | 0.15 | 0.05 | enet | 15 | 0.07 | 1.1e-05 | -10.4 | -9.9 | 5.6e-23 | 0.77 | 0.10 | 0.89 | FALSE |
13 | GTEx | Colon Sigmoid | FADS2 | 0.24 | 0.12 | lasso | 5 | 0.13 | 2.2e-05 | -4.3 | -6.1 | 8.2e-10 | 0.55 | 0.08 | 0.78 | FALSE |
14 | GTEx | Colon Transverse | FADS2 | 0.18 | 0.11 | lasso | 7 | 0.16 | 8.1e-08 | -6.3 | -9.2 | 3.2e-20 | 0.75 | 0.08 | 0.92 | FALSE |
15 | GTEx | Esophagus Gastroesophageal Junction | FADS2 | 0.22 | 0.22 | lasso | 2 | 0.20 | 7.8e-08 | -6.3 | -6.3 | 3.5e-10 | 0.57 | 0.34 | 0.56 | FALSE |
16 | GTEx | Esophagus Mucosa | FADS1 | 0.11 | 0.00 | lasso | 4 | 0.02 | 1.9e-02 | -10.7 | 10.6 | 2.0e-26 | -0.85 | 0.03 | 0.91 | TRUE |
17 | GTEx | Esophagus Muscularis | FADS2 | 0.32 | 0.30 | lasso | 6 | 0.31 | 3.7e-19 | -6.3 | -7.8 | 9.2e-15 | 0.70 | 0.99 | 0.01 | FALSE |
18 | GTEx | Heart Atrial Appendage | FADS2 | 0.16 | 0.11 | lasso | 1 | 0.04 | 5.1e-03 | -6.3 | -6.3 | 2.7e-10 | 0.58 | 0.11 | 0.76 | FALSE |
19 | GTEx | Heart Left Ventricle | FADS2 | 0.17 | 0.12 | enet | 3 | 0.13 | 1.5e-07 | -7.2 | -7.9 | 3.0e-15 | 0.72 | 0.24 | 0.76 | FALSE |
20 | GTEx | Muscle Skeletal | FADS2 | 0.08 | 0.04 | lasso | 2 | 0.03 | 5.9e-04 | -11.6 | -10.7 | 1.5e-26 | 0.94 | 0.01 | 0.99 | FALSE |
21 | GTEx | Nerve Tibial | DAGLA | 0.13 | 0.07 | lasso | 4 | 0.06 | 7.6e-05 | 6.2 | -6.2 | 5.3e-10 | 0.28 | 0.18 | 0.03 | FALSE |
22 | GTEx | Nerve Tibial | FADS2 | 0.20 | 0.14 | lasso | 3 | 0.13 | 1.5e-09 | -6.3 | -6.5 | 8.7e-11 | 0.60 | 0.84 | 0.16 | FALSE |
23 | GTEx | Pancreas | FADS1 | 0.17 | 0.13 | lasso | 6 | 0.12 | 1.2e-05 | -11.2 | 11.6 | 4.7e-31 | -0.91 | 0.03 | 0.97 | FALSE |
24 | GTEx | Spleen | MYRF | 0.23 | 0.00 | lasso | 4 | -0.01 | 4.6e-01 | -6.5 | -7.4 | 1.4e-13 | 0.52 | 0.04 | 0.33 | TRUE |
25 | GTEx | Spleen | FADS2 | 0.30 | 0.27 | lasso | 3 | 0.27 | 1.6e-07 | -6.3 | -8.0 | 1.9e-15 | 0.71 | 0.08 | 0.90 | FALSE |
26 | GTEx | Testis | DAGLA | 0.26 | 0.16 | enet | 11 | 0.09 | 1.1e-04 | 6.2 | -5.9 | 4.4e-09 | 0.27 | 0.54 | 0.04 | FALSE |
27 | GTEx | Thyroid | FADS2 | 0.16 | 0.18 | lasso | 4 | 0.17 | 7.0e-13 | -6.3 | -6.4 | 1.4e-10 | 0.59 | 1.00 | 0.00 | FALSE |
28 | GTEx | Uterus | PPP1R32 | 0.66 | -0.01 | lasso | 13 | 0.14 | 8.8e-04 | -2.7 | -9.2 | 2.7e-20 | 0.58 | 0.02 | 0.49 | FALSE |
29 | GTEx | Whole Blood | MYRF | 0.17 | 0.03 | lasso | 5 | 0.04 | 2.4e-04 | 6.2 | -5.1 | 2.7e-07 | 0.18 | 0.53 | 0.02 | FALSE |
30 | GTEx | Whole Blood | FADS2 | 0.49 | 0.48 | lasso | 5 | 0.48 | 3.0e-49 | -6.3 | -6.6 | 4.7e-11 | 0.60 | 1.00 | 0.00 | FALSE |
31 | METSIM | Adipose | FADS2 | 0.07 | 0.05 | lasso | 3 | 0.04 | 3.2e-07 | -6.3 | -5.6 | 1.9e-08 | 0.55 | 0.97 | 0.01 | TRUE |
32 | METSIM | Adipose | MYRF | 0.08 | 0.06 | lasso | 1 | 0.06 | 2.4e-09 | 6.1 | -6.1 | 1.3e-09 | 0.31 | 1.00 | 0.00 | FALSE |
33 | METSIM | Adipose | TMEM258 | 0.04 | 0.00 | bslmm | 407 | 0.01 | 4.1e-02 | -11.2 | -5.6 | 2.2e-08 | 0.65 | 0.02 | 0.89 | FALSE |
34 | NTR | Blood | C11orf10 | 0.06 | 0.08 | bslmm | 399 | 0.08 | 1.3e-24 | -10.4 | -10.5 | 1.3e-25 | 0.91 | 0.08 | 0.92 | FALSE |
35 | NTR | Blood | FADS2 | 0.30 | 0.33 | lasso | 7 | 0.33 | 9.0e-109 | -6.3 | -6.9 | 4.7e-12 | 0.63 | 1.00 | 0.00 | FALSE |
36 | ROSMAP | Brain Pre-frontal Cortex | TMEM258 | 0.14 | 0.16 | lasso | 4 | 0.15 | 4.7e-19 | -10.4 | -10.8 | 5.4e-27 | 0.92 | 0.11 | 0.89 | FALSE |
37 | ROSMAP | Brain Pre-frontal Cortex | FADS1 | 0.08 | 0.08 | enet | 10 | 0.09 | 1.5e-11 | -11.5 | 11.6 | 6.0e-31 | -0.95 | 0.01 | 0.99 | FALSE |
38 | YFS | Blood | CD5 | 0.06 | 0.01 | enet | 21 | 0.04 | 2.3e-13 | -5.0 | -7.8 | 7.5e-15 | 0.13 | 0.86 | 0.14 | TRUE |
39 | YFS | Blood | FADS1 | 0.11 | 0.08 | lasso | 8 | 0.09 | 6.1e-29 | -6.3 | -9.0 | 2.1e-19 | 0.76 | 1.00 | 0.00 | FALSE |
40 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FADS1 | 0.04 | 0.00 | blup | 53 | 0.01 | 1.4e-03 | -2.5 | 7.3 | 2.0e-13 | -0.62 | 0.02 | 0.38 | FALSE |
41 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FADS2 | 0.05 | 0.04 | lasso | 2 | 0.04 | 2.2e-09 | -6.3 | -6.1 | 1.2e-09 | 0.56 | 0.98 | 0.02 | FALSE |
42 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RPLP0P2 | 0.03 | 0.04 | enet | 4 | 0.04 | 2.2e-08 | 5.7 | 6.0 | 2.0e-09 | -0.11 | 0.05 | 0.95 | TRUE |
43 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FADS1 | 0.06 | 0.03 | lasso | 4 | 0.04 | 7.4e-03 | -11.2 | 10.6 | 4.1e-26 | -0.81 | 0.02 | 0.70 | FALSE |
44 | The Cancer Genome Atlas | Colon Adenocarcinoma | FADS2 | 0.30 | 0.21 | lasso | 2 | 0.22 | 6.7e-13 | -6.3 | -8.4 | 5.6e-17 | 0.75 | 0.67 | 0.33 | FALSE |
45 | The Cancer Genome Atlas | Colon Adenocarcinoma | RPLP0P2 | 0.10 | 0.06 | blup | 30 | 0.07 | 5.6e-05 | 5.7 | 5.6 | 2.1e-08 | -0.09 | 0.02 | 0.70 | FALSE |
46 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FADS2 | 0.05 | 0.04 | lasso | 3 | 0.05 | 1.9e-06 | -6.3 | -7.3 | 3.1e-13 | 0.70 | 0.25 | 0.69 | FALSE |
47 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FADS2 | 0.26 | 0.29 | enet | 15 | 0.29 | 2.9e-33 | -6.3 | -8.2 | 1.8e-16 | 0.72 | 1.00 | 0.00 | FALSE |
48 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FADS2 | 0.33 | 0.27 | lasso | 9 | 0.35 | 9.3e-21 | -6.3 | -9.2 | 4.7e-20 | 0.78 | 0.64 | 0.36 | FALSE |
49 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FADS1 | 0.05 | 0.05 | blup | 53 | 0.04 | 6.8e-05 | -9.9 | 10.3 | 1.0e-24 | -0.86 | 0.04 | 0.96 | FALSE |
50 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | FADS1 | 0.20 | 0.01 | blup | 51 | 0.07 | 3.2e-04 | -11.4 | 10.3 | 7.1e-25 | -0.85 | 0.01 | 0.94 | FALSE |
51 | The Cancer Genome Atlas | Lung Adenocarcinoma | FADS2 | 0.04 | 0.04 | lasso | 4 | 0.02 | 1.7e-03 | -6.3 | -6.8 | 1.5e-11 | 0.62 | 0.07 | 0.75 | FALSE |
52 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FADS2 | 0.02 | 0.01 | blup | 71 | 0.02 | 1.9e-03 | -11.6 | -10.2 | 2.2e-24 | 0.90 | 0.02 | 0.85 | FALSE |
53 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RPLP0P2 | 0.03 | 0.04 | lasso | 2 | 0.03 | 3.2e-04 | 5.7 | 5.7 | 1.3e-08 | -0.08 | 0.04 | 0.88 | FALSE |
54 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FADS2 | 0.15 | 0.16 | lasso | 2 | 0.12 | 8.8e-06 | -6.3 | -6.7 | 1.6e-11 | 0.60 | 0.41 | 0.40 | FALSE |
55 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C11orf10 | 0.02 | 0.01 | enet | 11 | 0.01 | 1.6e-02 | -10.4 | -8.6 | 1.2e-17 | 0.77 | 0.01 | 0.76 | TRUE |
56 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FADS1 | 0.06 | 0.04 | blup | 53 | 0.03 | 2.0e-04 | -11.1 | 9.8 | 1.3e-22 | -0.68 | 0.06 | 0.55 | FALSE |
57 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FADS2 | 0.07 | 0.07 | lasso | 4 | 0.06 | 1.9e-06 | -6.3 | -7.5 | 4.5e-14 | 0.69 | 0.12 | 0.86 | FALSE |
58 | The Cancer Genome Atlas | Rectum Adenocarcinoma | FADS2 | 0.47 | 0.34 | lasso | 5 | 0.30 | 7.9e-08 | -6.3 | -7.6 | 3.1e-14 | 0.68 | 0.04 | 0.94 | FALSE |
59 | The Cancer Genome Atlas | Soft Tissue Sarcoma | C11orf9 | 0.08 | 0.01 | enet | 11 | 0.03 | 1.0e-02 | -4.5 | -6.1 | 8.6e-10 | 0.23 | 0.04 | 0.04 | FALSE |
60 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FADS2 | 0.15 | 0.05 | blup | 71 | 0.11 | 2.5e-08 | -6.3 | -7.3 | 1.9e-13 | 0.71 | 0.04 | 0.95 | TRUE |
61 | The Cancer Genome Atlas | Thyroid Carcinoma | C11orf10 | 0.02 | 0.02 | blup | 44 | 0.02 | 1.8e-03 | -10.0 | -11.7 | 1.2e-31 | 0.95 | 0.02 | 0.70 | TRUE |
62 | The Cancer Genome Atlas | Thyroid Carcinoma | FADS2 | 0.30 | 0.33 | lasso | 8 | 0.33 | 5.6e-33 | -6.3 | -7.9 | 3.1e-15 | 0.71 | 1.00 | 0.00 | FALSE |