Best TWAS P=2.79e-16 · Best GWAS P=4.61e-17 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Cerebellar Hemisphere | RP11-750H9.5 | 0.17 | 0.25 | lasso | 6 | 0.21 | 3.5e-06 | 5.50 | -5.5 | 3.7e-08 | 0.50 | 0.39 | 0.15 | FALSE |
2 | GTEx | Breast Mammary Tissue (Female) | PSMC3 | 0.02 | 0.01 | lasso | 1 | 0.04 | 2.5e-02 | -8.18 | 8.2 | 2.8e-16 | -0.98 | 0.02 | 0.38 | TRUE |
3 | GTEx | Lung | PSMC3 | 0.07 | 0.02 | lasso | 2 | 0.03 | 3.6e-03 | -5.94 | 5.5 | 3.6e-08 | -0.63 | 0.16 | 0.20 | FALSE |
4 | GTEx | Muscle Skeletal | SLC39A13 | 0.05 | 0.01 | lasso | 3 | 0.01 | 8.5e-02 | -5.94 | 7.6 | 3.8e-14 | -0.83 | 0.02 | 0.79 | FALSE |
5 | GTEx | Skin Sun Exposed Lower leg | PSMC3 | 0.20 | 0.05 | lasso | 7 | 0.10 | 1.2e-08 | -8.18 | 6.4 | 1.9e-10 | -0.79 | 0.03 | 0.97 | FALSE |
6 | METSIM | Adipose | PSMC3 | 0.06 | 0.03 | enet | 28 | 0.04 | 2.3e-06 | 4.53 | 5.9 | 4.3e-09 | -0.68 | 0.04 | 0.96 | FALSE |
7 | ROSMAP | Brain Pre-frontal Cortex | CELF1 | 0.03 | 0.01 | bslmm | 289 | 0.01 | 2.9e-02 | -5.73 | -7.5 | 7.9e-14 | 0.92 | 0.01 | 0.95 | FALSE |
8 | ROSMAP | Brain Pre-frontal Cortex | PSMC3 | 0.15 | 0.08 | bslmm | 285 | 0.10 | 5.1e-13 | -6.00 | 5.9 | 4.6e-09 | -0.74 | 0.03 | 0.97 | FALSE |
9 | YFS | Blood | NUP160 | 0.02 | 0.01 | blup | 290 | 0.01 | 1.7e-04 | 3.56 | 5.4 | 8.4e-08 | -0.58 | 0.17 | 0.73 | FALSE |
10 | The Cancer Genome Atlas | Colon Adenocarcinoma | KBTBD4 | 0.14 | 0.01 | blup | 13 | 0.02 | 1.6e-02 | 0.18 | 5.3 | 8.6e-08 | -0.74 | 0.00 | 0.00 | FALSE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PSMC3 | 0.10 | 0.05 | blup | 39 | 0.08 | 3.7e-09 | 2.08 | 5.6 | 2.2e-08 | -0.77 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SLC39A13 | 0.06 | 0.01 | blup | 58 | 0.04 | 9.3e-04 | -5.22 | 5.4 | 6.5e-08 | -0.54 | 0.03 | 0.30 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PSMC3 | 0.02 | 0.02 | blup | 39 | 0.02 | 5.7e-03 | 2.08 | 5.3 | 1.2e-07 | -0.75 | 0.02 | 0.41 | FALSE |