Best TWAS P=1.23e-10 · Best GWAS P=2.33e-10 conditioned to 0.277
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | METSIM | Adipose | KRT1 | 0.21 | 0.18 | bslmm | 787 | 0.18 | 1.4e-26 | 5.7 | 5.4 | 5.6e-08 | 0.84 | 0.02 | 0.98 | FALSE |
2 | The Cancer Genome Atlas | Breast Invasive Carcinoma | KRT1 | 0.27 | 0.35 | lasso | 5 | 0.34 | 2.0e-73 | 5.7 | 5.8 | 6.0e-09 | 0.84 | 0.07 | 0.93 | FALSE |
3 | The Cancer Genome Atlas | Colon Adenocarcinoma | KRT1 | 0.25 | 0.29 | lasso | 6 | 0.30 | 1.5e-17 | 5.7 | 5.9 | 2.9e-09 | 0.84 | 0.02 | 0.98 | FALSE |
4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | KRT1 | 0.32 | 0.36 | lasso | 3 | 0.35 | 1.9e-41 | 5.7 | 5.8 | 6.8e-09 | 0.85 | 0.07 | 0.93 | FALSE |
5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | KRT2 | 0.28 | 0.09 | enet | 19 | 0.18 | 8.9e-20 | 6.3 | 5.3 | 1.3e-07 | 0.71 | 0.00 | 1.00 | FALSE |
6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | KRT73 | 0.07 | 0.04 | enet | 5 | 0.05 | 7.1e-06 | 6.3 | 6.4 | 1.2e-10 | 0.92 | 0.00 | 1.00 | TRUE |
7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | KRT1 | 0.22 | 0.26 | lasso | 5 | 0.26 | 5.3e-15 | 5.7 | 5.7 | 1.6e-08 | 0.84 | 0.03 | 0.97 | FALSE |
8 | The Cancer Genome Atlas | Lung Adenocarcinoma | KRT1 | 0.35 | 0.44 | lasso | 4 | 0.44 | 1.5e-55 | 5.7 | 5.8 | 6.2e-09 | 0.84 | 0.06 | 0.94 | FALSE |
9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | KRT1 | 0.06 | 0.00 | blup | 93 | 0.01 | 2.7e-02 | -3.0 | 5.5 | 3.3e-08 | 0.60 | 0.01 | 0.85 | FALSE |
10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | KRT1 | 0.35 | 0.43 | enet | 12 | 0.44 | 3.6e-20 | 6.0 | 6.1 | 1.3e-09 | 0.85 | 0.01 | 0.99 | FALSE |
11 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | KRT1 | 0.21 | 0.15 | lasso | 3 | 0.16 | 9.6e-07 | 5.7 | 6.0 | 2.4e-09 | 0.87 | 0.02 | 0.98 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | KRT1 | 0.26 | 0.40 | lasso | 3 | 0.40 | 3.3e-44 | 5.7 | 5.7 | 9.4e-09 | 0.84 | 0.06 | 0.94 | FALSE |
13 | The Cancer Genome Atlas | Rectum Adenocarcinoma | KRT1 | 0.45 | 0.35 | enet | 19 | 0.27 | 4.0e-07 | 6.0 | 6.3 | 3.0e-10 | 0.78 | 0.02 | 0.98 | FALSE |
14 | The Cancer Genome Atlas | Soft Tissue Sarcoma | KRT1 | 0.17 | 0.16 | enet | 15 | 0.16 | 6.2e-10 | 6.1 | 5.8 | 7.2e-09 | 0.77 | 0.01 | 0.99 | FALSE |
15 | The Cancer Genome Atlas | Stomach Adenocarcinoma | KRT1 | 0.17 | 0.24 | lasso | 3 | 0.23 | 9.3e-17 | 5.7 | 6.0 | 1.5e-09 | 0.91 | 0.01 | 0.99 | FALSE |
16 | The Cancer Genome Atlas | Thyroid Carcinoma | KRT1 | 0.12 | 0.09 | lasso | 5 | 0.08 | 2.0e-08 | 5.7 | 5.9 | 4.6e-09 | 0.84 | 0.02 | 0.98 | FALSE |