Best TWAS P=5.28e-11 · Best GWAS P=2.38e-12 conditioned to 2.56e-06
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | B4GALT3 | 0.21 | 0.05 | enet | 23 | 0.11 | 1.6e-09 | 5.8 | 6.3 | 2.8e-10 | -0.59 | 0.10 | 0.90 | FALSE |
2 | GTEx | Cells Transformed fibroblasts | PPOX | 0.14 | 0.14 | lasso | 4 | 0.13 | 6.0e-10 | 5.8 | 5.6 | 2.3e-08 | -0.27 | 0.78 | 0.22 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | B4GALT3 | 0.31 | 0.28 | enet | 16 | 0.30 | 2.0e-22 | 5.8 | 6.6 | 5.3e-11 | -0.42 | 0.77 | 0.23 | TRUE |
4 | GTEx | Cells Transformed fibroblasts | ADAMTS4 | 0.35 | 0.22 | lasso | 7 | 0.26 | 1.5e-19 | 5.8 | 6.5 | 7.4e-11 | -0.39 | 0.80 | 0.20 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | NDUFS2 | 0.11 | 0.07 | lasso | 3 | 0.10 | 1.2e-07 | -5.1 | 6.1 | 8.3e-10 | -0.58 | 0.08 | 0.88 | FALSE |
6 | GTEx | Nerve Tibial | B4GALT3 | 0.14 | 0.04 | lasso | 3 | 0.04 | 1.5e-03 | 5.8 | 5.3 | 1.3e-07 | -0.21 | 0.09 | 0.33 | FALSE |
7 | METSIM | Adipose | FCER1G | 0.15 | 0.11 | enet | 15 | 0.12 | 6.3e-17 | 5.8 | 6.5 | 1.1e-10 | -0.37 | 0.69 | 0.31 | FALSE |
8 | NTR | Blood | FCER1G | 0.17 | 0.14 | lasso | 6 | 0.16 | 3.4e-49 | 5.8 | 5.3 | 1.5e-07 | -0.19 | 0.80 | 0.20 | FALSE |
9 | YFS | Blood | FCER1G | 0.46 | 0.42 | lasso | 8 | 0.45 | 4.2e-166 | 5.8 | 6.4 | 2.0e-10 | -0.33 | 0.79 | 0.21 | FALSE |
10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FCER1G | 0.03 | 0.02 | lasso | 4 | 0.03 | 1.8e-06 | -4.6 | 6.0 | 2.7e-09 | -0.49 | 0.93 | 0.03 | FALSE |
11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FCER1G | 0.04 | 0.00 | enet | 11 | 0.02 | 4.2e-03 | -3.5 | 5.3 | 1.1e-07 | -0.67 | 0.02 | 0.85 | FALSE |
12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FCER1G | 0.06 | 0.02 | blup | 71 | 0.05 | 2.7e-06 | -4.4 | 6.5 | 9.7e-11 | -0.50 | 0.33 | 0.26 | FALSE |