Hub : Genes

B4GALT3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.2150 0.0600 6.3e-06 0.048 NA 0.113 NA 0.112 8.3e-05 NA 1.6e-09 NA 1.9e-09
2 GTEx Artery Aorta 0.0820 0.0380 9.7e-03 0.016 NA -0.003 NA 0.011 4.2e-02 NA 5.2e-01 NA 8.1e-02
3 GTEx Cells Transformed fibroblasts 0.3100 0.0510 1.2e-13 0.276 NA 0.295 NA 0.273 8.3e-21 NA 2.0e-22 NA 1.4e-20
4 GTEx Nerve Tibial 0.1382 0.0554 7.3e-03 0.037 NA 0.028 NA 0.035 1.2e-03 NA 4.4e-03 NA 1.5e-03
5 METSIM Adipose 0.0494 0.0194 3.9e-04 0.025 0.020 0.036 0.027 0.037 8.8e-05 5.0e-04 3.2e-06 5.9e-05 2.7e-06
6 YFS Blood 0.0366 0.0139 2.4e-05 0.022 0.015 0.014 0.018 0.022 9.7e-08 7.3e-06 1.5e-05 8.4e-07 7.3e-08
7 TCGA Brain Lower Grade Glioma 0.0310 0.0170 2.9e-03 0.028 0.013 0.007 NA 0.014 3.4e-04 1.0e-02 4.8e-02 NA 8.4e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 2.6 4.2 12.4 -1.3 1.4 -1.6 -1.8 -1.6 -2.3 -3.5
Bipolar Disorder or Schizophrenia 2.1 5.1 12.3 -1.7 0.9 -2.1 -2.9 -1.7 -2.0 -3.5
Depressed Affect (Nagel 2018) 0.4 0.9 3.0 -1.1 1.7 -0.9 -0.6 -0.1 -0.6 -0.8
Depression (Nagel 2018) 0.9 1.4 4.5 0.8 2.1 0.1 0.5 1.5 1.4 0.4
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.6 -0.1 -0.7 -0.3 -0.1 0.7 0.5 0.8
Neuroticism (Nagel 2018) 0.2 0.6 1.8 -0.6 0.8 -0.5 0.0 -0.6 -0.7 -1.4
Schizophrenia (2018) 0.9 1.8 5.3 -1.2 0.1 -1.4 -2.3 -0.9 -0.8 -1.6
Schizophrenia vs Biploar Disorder 2.1 2.7 4.6 2.1 -1.5 1.9 1.3 1.7 1.8 0.9
Worry (Nagel 2018) 0.5 1.1 1.9 -1.3 0.2 -1.4 -0.9 -0.9 -1.0 -1.3
Alzheimer’s Disease (in mother) 7.7 9.0 13.2 -3.0 0.7 -3.6 -3.1 -2.8 -3.4 -3.3
Alzheimer’s Disease (in father) 4.4 4.8 7.0 -2.1 -1.5 -2.3 -1.9 -2.4 -2.4 -2.6
Alzheimer’s Disease (including proxy) 12.9 18.8 28.2 -4.7 -0.1 -5.3 -4.8 -4.2 -4.8 -4.3
Crohns Disease (2017) 1.6 3.6 9.1 1.8 3.0 1.5 1.2 0.4 0.0 -3.0
Irritable Bowel Disease (IBD) 2.1 4.9 14.4 1.8 3.6 0.6 1.3 -0.1 -1.3 -3.8
Ulcerative Colitis (UC) 2.1 4.0 11.4 1.1 3.4 -0.2 0.9 -0.7 -2.0 -3.1
Major Depression (MDD) 0.5 0.6 1.0 0.3 0.9 -1.0 -0.6 1.0 0.0 -1.0
Reaction Time 0.3 0.6 1.7 -0.7 0.1 -0.9 -1.3 0.1 -0.5 -1.1
Verbal and Numeric Reasoning (VNR) 0.2 0.4 1.7 -0.8 -0.8 -1.3 -0.3 0.1 -0.3 -0.2
Breast Cancer 0.4 1.0 1.9 0.8 1.2 0.3 0.7 1.4 0.8 1.3
Ovarian Cancer 0.7 0.9 3.2 0.7 0.5 1.8 0.2 0.9 1.2 0.5
Prostate Cancer 0.1 0.2 0.5 -0.2 0.7 0.3 -0.4 0.3 0.3 0.3
Age at First Birth 0.6 0.8 2.9 -0.7 -0.2 -0.3 0.0 -1.1 -1.7 -0.9
Bipolar Disorder (2011) 1.7 1.6 2.7 -1.4 0.4 -1.7 -1.0 -1.3 -1.4 -1.4
Body Mass Index (BMI) (2010) 0.5 0.7 1.5 0.8 0.3 0.9 0.3 0.9 1.2 1.0
Coronary Artery Disease (CAD) 0.9 1.0 2.0 -0.7 0.5 -1.4 -0.2 -1.2 -1.4 -0.9
Crohns Disease (2012) 0.7 1.1 2.5 1.1 1.4 1.1 0.8 0.1 -0.2 -1.6
Mean Putamen Volume 1.6 1.8 4.4 1.4 2.1 0.3 1.2 1.8 1.2 -0.5
Fasting Glucose 0.5 0.6 1.9 0.5 -0.0 0.9 0.6 0.8 -0.3 1.4
HbA1C 1.7 1.9 6.1 1.8 -1.1 2.5 1.3 0.7 0.8 -0.2
HDL Cholesterol 0.6 1.0 2.2 -0.3 -1.2 -1.1 0.5 -1.2 -1.5 -0.4
LDL Cholesterol 0.7 1.2 3.2 1.2 1.8 -0.1 1.5 -0.3 -0.8 -0.8
Lupus 5.0 7.6 19.2 -3.9 0.8 -2.9 -4.4 -2.1 -1.9 -1.3
Neuroticism (2016) 1.0 1.4 8.5 -0.3 -0.1 -0.5 -0.1 -0.4 -1.0 -2.9
Primary Biliary Cirrhosis 0.2 0.3 0.8 0.9 0.2 -0.5 0.3 0.8 0.8 0.1
Rheumatoid Arthritis 2.1 2.9 9.8 2.4 0.2 1.7 3.1 0.2 -0.3 -1.2
Schizophrenia (2014) 0.9 1.9 6.9 -1.6 -0.8 -1.4 -2.6 -0.6 -0.4 -0.9
Triglycerides 0.6 1.0 2.6 1.1 0.4 1.1 0.9 1.6 1.0 0.0
Type 2 Diabetes (T2D) (2012) 0.5 0.5 2.7 0.3 1.6 0.0 0.3 -0.5 -0.7 -0.5
Ulcerative Colitis 1.6 2.4 8.0 1.6 2.8 -0.1 0.8 0.8 -0.4 -2.2
Blood Eosinophil Count 3.0 22.9 43.0 6.3 -4.1 6.6 5.3 4.0 4.2 0.4
Blood Platelet Count 1.4 15.9 38.7 -6.2 -3.2 -4.0 -4.3 -3.9 -3.2 -1.7
Blood Red Count 1.3 12.7 32.9 5.7 0.0 3.8 4.1 3.4 3.4 1.2
Blood White Count 3.5 26.1 42.4 6.4 3.6 5.8 3.7 5.8 6.5 2.3
Heel T-Score 0.5 3.8 10.0 -1.3 1.0 -1.4 -1.6 -2.4 -2.0 -3.2
BMI 0.7 4.1 10.4 0.5 1.3 -0.3 -1.9 2.5 3.2 2.5
Height 0.1 2.4 4.3 -2.1 -2.0 -1.5 -2.0 -1.1 -0.8 -0.0
Waist Hip Ratio (WHR) 2.5 11.1 16.5 -3.3 -2.2 -3.5 -2.5 -3.5 -3.9 -4.1
Systolic Blood Pressure 0.4 2.0 9.5 0.4 0.2 0.3 0.0 1.6 1.3 3.1
Smoking Status 0.0 0.1 0.2 0.1 0.3 -0.2 0.3 0.3 -0.1 -0.5
Allergy or Eczema 4.9 12.9 38.4 4.3 -1.2 6.2 5.3 1.3 1.5 0.8
Cardiovascular Disease 0.3 0.8 2.6 1.0 1.6 -0.6 -0.6 0.7 0.8 0.7
Hypothyroidism (self reported) 1.0 2.2 6.7 -1.9 0.0 -1.1 -2.6 0.2 0.2 2.0
Respiratory disease 3.2 7.1 19.7 3.4 0.3 4.1 4.4 0.6 0.8 0.4
Type 2 Diabetes (T2D) (2018) 0.5 1.0 3.1 -1.2 0.3 -1.2 -1.8 -0.1 0.2 -1.0
Lung FEV1/FVC ratio 0.3 1.6 2.7 -1.0 1.4 -0.3 -1.6 1.5 1.0 -1.6
Lung FVC 0.3 1.3 3.7 1.0 1.9 -0.6 -0.2 1.8 0.6 -0.6
Neuroticism 0.5 1.1 4.4 -1.1 0.2 -1.0 -0.6 -0.8 -0.5 -2.1
Chronotype (morning person) 0.8 1.8 6.0 1.1 0.3 2.2 2.4 -0.4 -0.1 0.4
Hair Pigment 0.0 0.9 4.4 -0.5 2.1 -0.8 -0.2 0.1 -0.7 -0.4
Tanning 0.3 3.2 5.8 1.7 -1.1 1.4 1.5 2.2 2.4 1.7
Hand grip strength (left) 1.5 4.0 8.9 2.3 0.6 2.5 0.6 2.1 3.0 1.6
Number of treatments/medications taken 0.6 1.0 1.9 1.4 1.0 1.2 1.1 0.5 0.5 1.0
Average weekly spirits intake 0.6 0.8 1.9 0.3 -1.4 -0.2 0.9 -1.0 -1.0 -0.7
Sensitivity / hurt feelings 0.3 0.4 1.4 0.1 1.2 -1.0 0.3 -0.3 -0.3 -0.4
Frequency of depressed mood in last 2 weeks 0.7 1.0 2.0 0.9 1.3 0.0 0.1 1.4 1.1 -1.0
Hearing difficulty/problems: Yes 1.3 1.9 3.7 1.2 1.3 1.1 0.2 1.7 1.9 1.6
Relative age of first facial hair 0.3 0.6 2.2 -0.9 -0.1 -0.5 -1.5 0.2 0.3 -0.7
Other serious medical condition/disability diagnosed by doctor 0.2 0.2 1.0 0.1 -0.2 0.4 0.3 -0.3 0.0 1.0
Ever used hormone-replacement therapy (HRT) 0.6 0.8 2.0 -0.6 1.4 -0.3 -1.3 0.6 1.0 0.0
Ever had hysterectomy (womb removed) 0.5 0.5 2.3 -0.2 1.5 -0.2 -0.6 0.6 0.6 0.3
Systolic blood pressure, automated reading 0.4 1.0 2.7 -0.6 0.6 -0.4 -1.3 1.0 1.0 1.6
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.7 0.1 0.8 0.3 -0.7 0.7 0.8 0.0
Angina 0.3 0.5 1.5 -0.6 -0.5 0.1 0.2 -1.2 -0.9 -0.4
Medication for hormone replacement therapy 0.5 0.5 2.0 -0.2 -0.4 1.0 -0.2 -0.6 -0.1 -1.4
Vitamin and mineral supplements 1.0 1.3 2.9 -0.6 -1.1 -1.3 0.1 -1.7 -1.7 -0.6
Supplements: Zinc 0.9 1.0 4.2 -1.4 -0.4 -0.8 -2.1 -0.5 0.0 -0.2
Medication: Co-codamol 0.4 0.5 1.3 0.6 1.1 -0.3 -0.8 0.1 0.6 -0.9
Medication: Metformin 1.0 1.4 3.6 -0.8 1.1 -1.2 -1.9 0.3 0.3 -1.7
Diabetes (father) 0.6 0.7 1.1 -0.8 -1.1 -1.0 -0.9 -0.5 -0.5 -0.9
Diabetes (mother) 1.8 2.4 4.0 -2.0 -0.6 -1.6 -1.5 -1.8 -1.9 -0.8
Severe depression (siblings) 1.1 1.3 2.7 -1.0 0.0 -1.0 -1.3 -1.0 -1.2 -1.6
Pack years adult smoking proportion 1.2 1.9 4.6 -1.4 -0.1 -1.5 -1.0 -2.1 -1.6 -0.6
Impedance of leg (right) 0.2 1.0 2.3 1.4 -0.5 0.4 0.2 1.4 0.6 -1.5
Leg fat-free mass (left) 0.6 2.9 8.0 -2.3 -0.4 -2.0 -2.8 -1.3 -0.6 0.9
Trunk fat percentage 0.8 3.2 8.3 -0.3 1.1 -1.1 -2.9 1.9 2.7 0.9
Hand grip strength (right) 1.2 3.1 9.4 1.5 1.0 1.7 -0.6 2.1 3.1 1.2
Townsend deprivation index at recruitment 0.3 0.4 2.6 0.3 -1.6 0.1 -0.2 0.2 0.5 0.1
Current tobacco smoking 0.4 0.6 1.6 0.1 0.0 -0.6 0.6 -0.7 -1.1 -1.3
Average weekly fortified wine intake 1.8 2.1 4.3 -1.2 1.4 -1.1 -0.8 -2.1 -1.8 -1.4
Maternal smoking around birth 0.3 0.5 0.9 -0.8 -0.9 -0.0 -0.2 -0.9 -0.5 -1.0
Fed-up feelings 0.7 1.2 2.2 -1.1 1.4 -1.5 -0.6 -0.4 -1.1 -1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 3.1 0.4 1.8 -0.3 -0.3 1.2 1.2 0.0
Relative age voice broke 1.3 2.0 3.3 -1.8 -1.6 -1.4 -1.8 -0.8 -0.6 -1.4
Taking other prescription medications 1.5 2.3 4.3 2.1 1.1 1.8 1.7 1.2 1.1 1.4
Age when periods started (menarche) 0.5 1.2 5.0 -0.1 -2.2 0.3 -0.8 -0.1 -0.2 -1.6
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.8 -0.9 0.4 0.1 -0.7 -0.2 -0.3 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 2.5 -0.0 1.6 0.2 -0.2 -0.8 -0.3 -1.0
Tinnitus: Yes, but not now, but have in the past 1.9 2.0 3.8 -1.9 -1.9 -1.7 -1.8 -0.6 -0.4 0.1
Qualifications: CSEs or equivalent 0.1 0.2 0.4 -0.2 0.5 -0.3 -0.6 0.4 -0.3 0.2
Serious illness, injury or assault to yourself 0.5 0.7 2.2 0.6 -0.6 1.1 1.5 -0.1 0.6 0.3
High blood pressure 0.7 1.9 5.3 -1.0 1.7 -1.9 -2.3 -0.2 -0.3 0.6
Hayfever, allergic rhinitis or eczema 4.2 9.0 29.2 3.6 -1.3 5.4 3.9 1.2 1.6 0.7
Multivitamins +/- minerals 1.8 2.3 5.4 1.6 1.4 1.3 0.3 2.3 2.2 -0.1
Stomach or abdominal pain in last month 1.4 1.7 3.0 1.7 1.3 1.4 1.0 1.4 1.0 -1.3
Supplements: Glucosamine 0.5 0.6 3.2 -0.6 1.8 0.5 -0.5 -0.0 0.2 0.6
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 3.2 0.9 0.8 0.7 0.5 1.0 0.8 -1.8
Medication: Atenolol 0.6 0.7 2.3 -0.7 1.5 0.2 -0.5 -0.3 0.1 1.3
Medication: Levothyroxine sodium 1.1 1.9 4.6 -1.9 0.9 -0.7 -2.1 0.1 0.3 1.9
Sitting height 0.2 1.2 2.0 -1.4 -0.6 -1.4 -1.2 -1.2 -0.7 0.7
Chronic bronchitis/emphysema (father) 0.3 0.3 1.1 0.6 0.4 0.6 1.1 -0.4 -0.0 -0.4
High blood pressure (mother) 0.2 0.2 1.4 -0.2 -0.0 -0.1 0.2 0.0 0.4 1.2
Body mass index (BMI) 0.4 1.7 6.0 -1.0 0.8 -1.1 -2.4 0.4 1.3 1.2
Impedance of leg (left) 0.2 1.2 2.9 1.5 0.0 0.5 0.7 1.3 0.6 -1.7
Leg predicted mass (left) 0.5 2.8 7.7 -2.3 -0.4 -2.0 -2.8 -1.3 -0.6 0.9
Trunk fat mass 0.7 3.2 10.7 -0.9 0.9 -1.3 -3.3 1.3 2.2 1.1
Waist circumference 1.0 3.8 12.7 -2.4 0.2 -2.7 -3.6 -0.7 0.1 0.0
Number of incorrect matches in round 0.8 1.3 2.4 0.7 1.5 0.7 0.8 1.2 1.6 1.1
Past tobacco smoking 0.2 0.4 1.8 -0.1 -1.3 -0.1 0.7 -0.2 -0.4 0.0
Alcohol usually taken with meals 0.5 0.7 1.7 -0.7 -0.6 0.2 0.4 -1.1 -1.3 -1.2
Nervous feelings 1.2 2.3 6.0 -0.8 0.8 -2.1 -0.9 -1.2 -1.4 -2.4
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 3.0 0.6 1.6 -0.2 -0.7 1.7 1.5 -0.7
Hearing difficulty/problems with background noise 0.1 0.2 0.6 0.6 0.4 0.2 -0.3 0.1 0.2 -0.8
Hair/balding pattern: Pattern 2 0.6 0.7 2.5 -0.3 1.6 -0.3 -0.5 -0.1 0.6 1.3
Had menopause 0.9 1.1 3.0 -0.7 -0.5 -0.3 -0.2 -1.7 -1.1 -1.6
Had other major operations 0.3 0.4 1.5 -0.3 1.2 -0.3 -0.9 0.4 0.2 -0.1
Forced vital capacity (FVC) 0.2 0.9 3.3 1.2 -0.1 0.1 0.2 1.8 1.3 0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 3.6 0.0 1.9 0.5 0.0 -0.2 0.2 -0.8
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 1.5 0.1 1.2 -0.1 0.1 0.2 0.4 -0.8
Qualifications: None of the above 0.3 0.6 2.4 -0.6 -1.0 0.0 -0.4 -0.2 0.4 1.6
Financial difficulties in last 2 years 1.7 2.3 6.2 -1.0 1.3 -2.5 -2.2 -0.6 -1.1 -0.9
Mouth/teeth dental problems 2.6 3.9 8.6 -1.0 0.1 -1.9 -2.9 2.0 2.1 2.4
Heart attack 1.4 1.8 5.2 1.9 0.6 2.3 1.6 0.7 0.9 0.4
Allergy 4.3 9.8 29.4 -4.1 0.6 -5.4 -4.4 -1.1 -1.2 0.2
Pain all over the body in last month 1.3 1.4 3.8 0.0 2.0 -0.8 -1.4 1.2 1.4 0.2
Diabetes (self-reported) 0.3 0.5 1.5 0.6 0.1 0.1 -0.4 1.2 1.1 -0.4
Hayfever/allergic rhinitis (self-reported) 5.6 7.4 21.6 3.2 -1.9 4.6 4.0 -0.5 0.2 -0.4
Medication: Ramipril 2.1 2.7 9.2 1.0 0.9 0.6 -0.6 3.0 2.3 1.3
Medication: Simvastatin 1.8 2.6 6.1 2.5 2.3 0.7 0.9 1.6 1.2 -1.2
Fluid intelligence score 0.3 0.6 1.4 -0.8 -1.2 -1.0 -0.4 0.0 -0.5 0.5
Illnesses of siblings 0.9 1.3 5.6 -0.7 -2.4 0.3 1.1 -0.7 -1.0 0.2
Neuroticism score 0.2 0.4 1.2 -0.3 1.1 -0.7 -0.0 -0.0 0.1 -0.8
Weight 0.5 2.5 9.3 -1.7 0.1 -1.6 -3.1 -0.2 0.9 1.3
Impedance of arm (right) 0.2 1.1 2.6 1.2 0.6 -0.0 -0.1 1.6 1.0 -1.5
Arm fat percentage (right) 0.8 3.1 6.9 -0.3 1.7 -0.8 -2.6 1.8 2.6 0.9
Trunk fat-free mass 0.7 3.7 7.6 -2.8 -1.1 -2.0 -2.6 -2.0 -1.3 0.7
Hip circumference 0.4 1.9 5.4 -0.9 0.1 -0.8 -2.3 0.5 1.6 1.8
Time employed in main current job 0.4 0.5 1.3 1.1 -0.4 -0.3 0.2 0.8 0.9 -0.7
Alcohol intake versus 10 years previously 0.4 0.7 1.4 0.4 1.2 0.1 -0.7 1.2 1.1 -0.1
Father’s age at death 0.5 0.6 1.8 0.4 0.0 0.1 1.0 -0.7 -1.3 -1.0
Worrier / anxious feelings 0.1 0.2 0.4 -0.4 0.6 -0.6 -0.5 -0.1 0.3 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.4 3.4 0.5 1.3 -0.2 -0.3 1.9 1.9 0.8
Falls in the last year 0.5 0.7 2.1 -0.2 -1.4 -0.4 -0.9 -0.5 -0.1 -1.3
Hair/balding pattern: Pattern 3 0.5 0.7 1.5 0.5 -0.4 1.0 1.2 0.0 -0.7 -1.2
Number of live births 0.5 0.7 1.2 -1.1 -0.6 -0.4 -1.0 -1.1 -0.8 -0.7
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 3.2 0.5 0.1 -0.1 -0.3 1.8 1.3 -0.2
Pulse rate 0.2 0.4 1.3 0.6 -0.7 -0.3 0.3 -0.3 0.1 -1.2
Happiness 0.2 0.2 0.8 0.1 0.9 -0.3 0.2 0.5 0.5 -0.2
Noisy workplace 2.1 2.6 6.0 1.6 0.5 1.3 0.7 2.3 2.4 1.3
Qualifications: A levels/AS levels or equivalent 0.9 1.9 6.0 -0.6 0.0 -1.0 -0.1 -1.0 -2.3 -2.5
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.0 -0.2 -0.8 -1.1 -0.8 0.1 -0.3 -1.4
Mouth/teeth dental problems: Dentures 4.8 8.0 24.5 2.9 0.3 5.0 4.1 1.3 1.9 1.0
Asthma 4.2 8.3 20.4 3.7 -0.6 4.5 4.4 1.2 1.4 0.8
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 3.8 0.8 -1.2 0.8 -0.1 1.0 1.3 2.0
Medication: Cholesterol lowering 1.5 2.3 7.8 1.9 2.8 1.0 1.1 1.0 1.0 -0.6
Depression (self-reported) 1.0 1.2 5.9 0.5 2.4 -0.1 0.6 0.4 0.8 -0.9
Medication: Lansoprazole 0.2 0.2 0.5 0.1 -0.7 -0.5 0.1 0.7 0.2 0.1
Prospective memory result 0.9 1.1 2.9 1.6 0.3 1.1 1.7 0.5 1.0 0.0
Lung cancer (father) 0.1 0.2 0.6 -0.8 -0.2 0.4 -0.4 -0.1 0.3 0.4
Illnesses of mother 1.4 1.8 3.1 1.0 -0.3 1.4 1.5 1.4 1.8 1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 1.9 -0.1 -0.3 -0.7 -1.4 1.2 1.0 -0.7
Pulse wave Arterial Stiffness index 0.3 0.4 1.3 -0.1 0.3 -0.2 -0.4 -0.9 -0.6 -1.1
Impedance of arm (left) 0.3 1.2 3.5 1.4 0.6 0.4 0.0 1.9 1.2 -1.1
Arm fat mass (right) 0.7 2.8 10.1 -1.1 0.6 -1.3 -3.2 1.0 1.9 1.2
Trunk predicted mass 0.6 3.7 7.6 -2.8 -1.1 -2.0 -2.6 -2.0 -1.3 0.6
Standing height 0.2 2.4 4.4 -2.1 -1.6 -1.7 -1.9 -1.4 -1.1 0.1
Length of working week for main job 0.6 0.6 2.2 0.7 -1.0 0.1 0.2 0.9 1.5 -0.0
Exposure to tobacco smoke at home 1.8 2.0 5.7 0.4 -1.1 0.3 -0.7 1.7 2.4 1.9
Breastfed as a baby 0.7 0.9 3.1 -0.6 -0.8 -1.7 -1.2 0.4 0.3 -0.4
Tense / ‘highly strung’ 0.8 1.3 3.9 -1.0 0.3 -1.9 -2.0 -0.6 -0.1 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 2.9 0.4 1.7 -0.5 0.9 -0.3 -0.6 -0.6
Hair/balding pattern: Pattern 4 0.3 0.8 1.8 1.1 0.4 0.2 1.4 1.2 0.8 0.6
Birth weight of first child 2.9 5.2 10.4 -3.2 -0.2 -2.0 -3.2 -2.1 -1.8 -2.0
Peak expiratory flow (PEF) 0.6 1.4 3.0 1.2 0.7 1.6 1.7 0.9 0.8 0.8
Pulse wave reflection index 0.3 0.4 1.8 -0.7 0.5 -0.4 -1.3 -0.2 0.1 -0.0
Ever highly irritable/argumentative for 2 days 0.0 0.0 0.1 -0.2 0.2 -0.3 -0.2 -0.0 0.1 0.2
Loud music exposure frequency 0.1 0.1 0.2 0.1 -0.4 -0.1 -0.4 -0.1 -0.2 0.2
Qualifications: O levels/GCSEs or equivalent 1.7 2.8 7.4 -1.9 1.7 -2.7 -2.2 0.1 -0.7 -0.0
Mouth/teeth dental problems: Bleeding gums 1.6 2.0 4.1 0.2 -0.4 -0.6 1.4 -2.0 -2.0 -1.9
Blood clot in the leg (DVT) 0.4 0.5 1.6 0.3 -0.1 -0.5 -0.5 -0.6 -1.0 -1.2
Medication: Paracetamol 0.8 1.3 2.6 -0.2 -0.3 -0.6 -1.6 1.6 1.5 1.1
Headache pain in last month 0.6 1.0 2.5 0.6 1.2 0.5 -0.5 1.5 1.6 0.5
Medication for cholesterol, blood pressure or diabetes 1.1 1.8 9.7 -1.3 -3.1 -0.3 -0.1 -0.8 -0.6 -0.2
Glaucoma (self-reported) 0.2 0.2 0.6 0.1 -0.6 0.1 -0.8 -0.2 0.2 -0.6
Gout (self-reported) 0.4 0.6 1.2 1.1 -0.0 1.1 1.1 -0.2 -0.2 -0.7
Hypothyroidism/myxoedema (self-reported) 1.4 2.8 7.9 -2.0 1.0 -1.1 -2.8 0.4 0.5 2.2
Medication: Amlodipine 0.3 0.4 1.2 -0.4 1.1 0.2 -0.7 -0.4 0.5 0.6
Medication: Ventolin 100micrograms inhaler 2.9 3.7 13.7 2.0 -1.0 3.7 2.4 0.1 1.2 0.5
Birth weight 0.8 1.7 3.8 -1.0 -1.0 0.3 -1.7 0.4 1.8 1.9
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.8 1.3 -0.9 0.6 0.0 1.3 0.8 -0.7
High blood pressure (siblings) 1.1 1.6 7.0 0.2 2.7 -0.4 -1.8 0.2 1.0 0.5
Forced vital capacity (FVC), Best measure 0.2 0.7 2.1 0.7 -0.3 -0.3 -0.8 1.4 1.3 0.1
Body fat percentage 0.8 3.1 8.6 -0.4 1.4 -1.0 -2.9 1.7 2.6 0.7
Leg fat percentage (right) 0.6 2.0 6.4 -0.4 1.2 -0.8 -2.5 1.2 1.9 0.6
Arm fat-free mass (right) 0.6 2.9 5.9 -2.3 -1.1 -1.8 -2.4 -1.7 -0.9 0.9
Exposure to tobacco smoke outside home 0.7 0.9 3.0 -0.8 -0.1 -0.6 -1.2 0.6 0.5 1.7
Comparative body size at age 10 1.3 3.5 9.1 0.2 2.0 0.5 -0.8 2.6 3.0 1.9
Number of full brothers 0.2 0.3 0.9 0.8 -0.5 -0.4 0.1 0.0 -0.0 -0.9
Worry too long after embarrassment 1.0 1.7 3.0 -1.4 -0.8 -1.4 -1.2 -1.7 -1.5 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.9 2.5 5.3 -0.8 0.7 -1.9 -0.3 -2.3 -2.3 -1.4
Wheeze or whistling in the chest in last year 1.6 2.9 5.5 1.7 -2.4 2.1 2.1 1.1 1.1 0.7
Number of children fathered 1.6 1.8 3.8 0.8 1.6 1.1 0.7 1.0 1.7 2.0
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 2.2 0.1 0.3 -0.4 -0.6 1.5 0.8 0.5
Age at first live birth 0.4 0.7 2.0 0.0 -0.7 0.0 0.9 -0.6 -1.4 -0.9
Pulse wave peak to peak time 0.2 0.3 1.4 -0.1 -0.2 0.0 0.2 0.6 0.4 1.2
Health satisfaction 0.6 0.7 3.1 -0.6 0.3 -1.8 -1.1 0.5 0.1 -0.2
Shortness of breath walking on level ground 0.3 0.4 0.7 -0.9 -0.5 -0.8 -0.7 -0.6 -0.5 -0.1
Qualifications: College or University degree 0.5 1.4 3.2 1.0 -0.9 0.7 1.7 -0.7 -1.1 -1.8
Eye problems/disorders: None of the above 0.5 0.6 3.3 -0.1 -1.8 -0.6 -0.2 0.8 0.2 -0.2
Mouth/teeth dental problems: Loose teeth 2.7 3.2 8.6 2.3 -0.0 2.9 2.6 0.2 0.8 1.1
Emphysema/chronic bronchitis 0.7 0.8 2.5 0.1 1.6 -0.3 -0.1 -0.6 -1.1 -1.3
Medication for pain relief, constipation, heartburn 0.7 1.1 2.9 -0.8 -0.3 -0.8 0.6 -1.7 -1.6 -1.0
Neck or shoulder pain in last month 0.3 0.4 0.9 -0.7 -1.0 0.9 -0.4 -0.3 0.5 0.4
Medication: Blood pressure 0.7 1.2 5.1 0.8 2.3 0.2 0.1 0.5 0.3 1.6
Angina (self-reported) 0.4 0.6 1.7 -1.0 -0.4 -0.2 -0.2 -1.3 -1.0 -0.2
Migraine (self-reported) 0.5 0.6 1.4 -0.8 -0.1 -0.7 -1.2 -1.0 -0.5 0.6
Medication: Ibuprofen 0.8 0.9 2.5 0.8 -1.2 0.5 0.2 0.8 0.9 1.6
Medication: Allopurinol 0.2 0.3 1.1 1.0 0.4 0.6 0.8 0.3 0.0 -0.0
Medication: Omeprazole 0.5 0.6 1.3 -0.8 -0.6 -0.4 -1.0 -0.9 -0.6 -1.1
Medication: Seretide 50 evohaler 1.6 1.8 3.9 1.1 -0.7 1.5 0.2 1.6 2.0 1.5
Mean time to correctly identify matches 0.3 0.5 1.0 -0.8 0.2 -0.5 -0.5 -0.6 -1.0 -1.0
Heart disease (mother) 0.2 0.3 0.7 0.3 -0.8 -0.4 -0.2 -0.6 -0.9 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.0 0.1 0.1 0.1 0.4 0.2 0.1 0.2 0.3
Whole body fat mass 0.7 3.0 11.4 -1.2 0.7 -1.6 -3.4 0.9 1.8 0.9
Leg fat mass (right) 0.6 2.3 9.7 -1.2 0.8 -1.4 -3.1 0.5 1.4 0.6
Arm predicted mass (right) 0.6 3.1 6.8 -2.4 -0.9 -1.9 -2.6 -1.8 -1.0 0.5
Pulse rate, automated reading 0.3 0.9 4.9 0.2 -2.2 -0.6 -0.5 -0.2 -0.0 -0.9
Alcohol intake frequency. 0.1 0.3 0.7 0.2 -0.6 -0.3 -0.8 0.3 0.5 -0.6
Comparative height size at age 10 0.1 0.8 2.0 -0.2 1.3 -0.9 -0.7 -0.4 0.2 1.4
Number of full sisters 0.5 0.6 3.0 -0.1 -0.1 -0.9 -1.7 -0.0 0.5 0.3
Suffer from ‘nerves’ 0.9 1.5 2.9 -1.2 1.6 -1.7 -1.7 -0.3 -0.2 -0.8
Overall health rating 0.6 1.3 3.0 0.4 1.1 0.3 -1.1 1.0 1.7 1.6
Chest pain or discomfort 0.7 1.0 2.2 -0.9 -1.5 -0.5 -1.2 -1.1 -0.9 -0.6
Had major operations 0.2 0.2 0.8 -0.6 -0.9 -0.2 -0.5 -0.4 0.2 0.2
Age at last live birth 0.9 1.3 3.0 -0.2 -1.7 -0.6 0.5 -1.1 -1.5 -1.3
Family relationship satisfaction 0.9 1.1 1.8 0.0 0.8 -1.3 -1.0 1.3 1.2 1.1
Leg pain on walking 0.8 1.0 1.8 -0.4 1.0 -1.3 -1.1 -0.6 -1.0 -1.2
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 1.0 -0.2 -0.8 0.2 0.5 -0.5 -0.2 1.0
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.2 0.5 1.1 0.6 0.1 0.6 0.8 -0.2
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.2 -1.1 0.5 -0.6 -0.7 -0.5 -0.5 0.8
Medication: Aspirin 1.2 1.6 3.6 1.6 0.9 1.9 1.3 0.8 0.8 1.0
Supplements: Vitamin C 1.3 1.5 3.7 -1.8 -0.4 -0.7 -1.7 -0.3 -0.0 1.9
Knee pain experienced in last month 0.6 1.0 2.6 -1.0 -0.7 -0.2 0.0 -1.4 -1.6 0.8
Hypertension (Self-reported) 0.6 1.7 4.2 -0.8 1.9 -1.8 -2.0 -0.2 -0.3 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 2.4 0.4 -0.7 0.9 0.8 0.1 0.7 1.6
Illnesses of father: Heart disease 0.6 0.9 1.8 0.4 -1.0 0.3 1.1 -1.3 -1.1 -0.8
Illnesses of siblings: Diabetes 0.9 1.1 2.7 0.0 0.7 -1.6 -1.6 1.1 0.7 -0.2
Smoking status: Previous 0.2 0.2 1.2 0.1 1.1 0.6 -0.4 -0.1 0.0 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.3 0.0 -0.6 -0.7 -1.1 0.8 0.7 0.9
Whole body fat-free mass 0.6 3.3 6.9 -2.5 -0.8 -2.0 -2.6 -1.8 -1.0 0.8
Leg fat-free mass (right) 0.5 2.7 6.4 -2.3 -0.4 -1.9 -2.5 -1.4 -0.6 0.9
Arm fat percentage (left) 0.7 3.0 7.6 -0.3 1.5 -0.7 -2.8 1.8 2.5 0.9
Average weekly red wine intake 0.5 0.8 2.7 0.6 -1.6 0.6 1.2 -0.3 -0.2 -0.4
Handedness (chirality/laterality): Left-handed 0.7 0.8 1.4 -1.0 -1.1 -1.2 -0.9 -0.8 -0.8 0.3
Mood swings 0.3 0.5 1.3 0.4 1.1 -0.1 0.8 -0.0 -0.4 -1.1
Loneliness, isolation 0.5 0.6 3.9 -0.2 2.0 0.1 -0.4 -0.1 0.1 0.6
Long-standing illness, disability or infirmity 0.8 1.3 2.9 1.7 1.5 0.3 0.3 1.2 1.1 1.0
Ever had bowel cancer screening 1.6 1.9 11.9 0.9 3.5 -0.6 0.4 0.3 0.1 -0.3
Diabetes diagnosed by doctor 0.4 0.7 2.1 -0.5 0.3 -0.9 -1.4 0.7 0.6 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.8 0.5 0.1 0.2 0.9 0.3 0.0 -0.2
Friendships satisfaction 0.5 0.6 1.8 -0.7 0.3 -1.3 -0.8 0.4 -0.1 1.0
Qualifications: nursing, teaching 0.8 1.3 5.2 0.6 2.3 -0.2 0.3 0.3 0.0 -1.8
Commuting to job workplace: Walk 0.3 0.3 0.7 0.5 -0.6 0.9 0.6 0.4 0.0 -0.5
Eye problems/disorders: Cataract 0.9 1.0 5.4 0.0 2.3 0.7 0.2 -0.9 -0.5 -0.4
Mouth/teeth dental problems: Mouth ulcers 6.2 9.8 21.0 -2.7 -1.2 -1.9 -0.9 -3.9 -4.6 -4.4
Medication for cholesterol 0.2 0.4 0.5 -0.4 -0.7 -0.7 0.3 -0.7 -0.6 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 3.3 1.3 1.2 1.8 1.0 0.9 1.2 0.4
Back pain experienced in last month 0.7 1.0 3.1 -0.7 -0.9 -0.1 -0.9 -1.8 -1.0 -1.0
Mineral and other dietary supplements 0.7 0.9 2.7 0.1 -0.1 -1.6 0.3 -0.6 -1.3 -1.1
Breast cancer (self-reported) 0.4 0.5 1.3 -0.6 -1.1 0.3 1.1 -0.4 -0.3 0.4
Asthma (self-reported) 4.3 8.7 21.1 3.7 -0.8 4.6 4.5 1.3 1.6 1.0
Osteoporosis (self-reported) 1.6 2.0 6.3 -0.9 2.5 -0.3 -1.5 0.9 1.1 1.6
Osteoarthritis (self-reported) 0.5 0.7 1.7 -1.0 1.0 -0.5 -0.7 -1.3 -0.3 0.5
Medication: Aspirin 0.8 1.0 3.0 1.2 -0.1 1.7 1.6 0.1 0.1 0.5
Medication: Gliclazide 0.6 0.7 1.5 -0.4 0.2 -1.2 -1.0 0.6 1.2 0.4
Illnesses of father: None of the above (group 1) 0.5 0.6 1.5 -1.2 -0.5 -0.5 -1.0 0.8 0.5 0.5
Smoking status: Current 0.2 0.3 0.9 0.3 0.1 -0.3 0.8 -0.4 -0.6 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.6 6.6 0.7 0.0 0.1 -0.7 2.6 1.9 -0.1
Whole body water mass 0.6 3.4 7.5 -2.6 -0.9 -2.0 -2.7 -1.7 -1.0 0.9
Leg predicted mass (right) 0.5 2.6 6.2 -2.3 -0.4 -1.9 -2.5 -1.4 -0.6 1.0
Arm fat mass (left) 0.7 3.0 10.6 -1.1 0.9 -1.4 -3.3 1.1 2.0 1.2
Number of self-reported non-cancer illnesses 0.5 0.9 1.7 1.2 1.1 0.9 1.3 -0.5 -0.5 0.6
Average weekly champagne plus white wine intake 0.3 0.4 1.0 -1.0 0.5 -0.4 -0.8 -0.4 -0.3 -1.0
Miserableness 0.7 1.3 3.6 -0.6 1.9 -1.4 -0.8 0.4 -0.4 -1.5
Guilty feelings 0.7 1.1 3.0 1.3 -0.4 1.3 1.7 -0.2 0.4 -1.0
Wears glasses or contact lenses 2.2 2.6 5.9 -1.7 0.9 -1.5 0.0 -2.2 -2.4 -1.1
Ever taken oral contraceptive pill 1.8 2.0 3.8 1.6 1.8 1.0 0.5 1.9 1.8 -0.3
Hearing aid user 2.2 2.5 5.8 -2.4 1.6 -0.8 -1.8 -1.5 -1.4 -1.0
Mother’s age at death 0.4 0.5 1.2 -1.0 -0.8 -0.1 -0.4 -0.3 -0.1 -1.1
Financial situation satisfaction 0.7 0.9 3.5 -0.3 -1.1 -1.9 -1.2 0.4 0.3 -0.1
Tinnitus: Yes, now most or all of the time 3.2 3.8 6.6 1.6 0.9 1.9 0.9 2.4 2.5 2.6
Commuting to job workplace: Public transport 0.3 0.3 1.2 0.0 -0.9 0.2 -0.1 0.3 -0.2 -1.1
Eye problems/disorders: Glaucoma 0.2 0.2 0.8 0.1 -0.4 0.1 -0.2 -0.9 -0.3 -0.6
Medication: Blood pressure 0.5 0.9 2.8 -0.4 1.7 -0.1 -1.3 0.9 0.9 -0.1
Pain type(s) experienced in last month: Hip pain 1.2 1.5 4.6 -0.5 -0.7 0.7 0.5 -2.1 -1.6 -1.5
Supplements: Fish oil (including cod liver oil) 0.5 0.7 2.3 -0.4 -0.9 1.5 -0.5 0.1 0.9 0.5
High cholesterol (Self-reported) 1.1 1.9 8.5 1.4 2.9 0.3 0.3 1.1 1.1 -0.7
Medication: Bendroflumethiazide 0.9 1.3 5.8 -0.2 2.4 -0.3 -1.1 1.0 1.0 0.2
Medication: Paracetamol 0.4 0.6 1.6 -0.2 -0.2 -0.2 -0.6 1.2 1.1 1.1
Medication: Lisinopril 1.0 1.3 3.2 -0.2 1.6 -0.7 -0.6 -1.0 -1.3 -1.8
Medication: Atorvastatin 1.2 1.5 3.1 1.4 1.8 1.5 1.7 0.2 0.4 0.2
Illnesses of father: High blood pressure 0.9 1.1 3.3 0.9 1.8 -1.0 -1.0 1.0 0.7 0.2
Alcohol drinker status: Never 1.0 1.3 3.0 -1.1 -1.7 -1.3 -1.6 0.0 -0.4 -0.4
Ever smoked 0.3 0.4 1.5 0.2 1.2 0.1 -0.8 0.5 0.6 -0.4
Basal metabolic rate 0.5 3.0 8.4 -2.4 -0.6 -1.9 -2.9 -1.3 -0.4 1.1
Leg fat percentage (left) 0.5 1.9 6.3 -0.6 1.4 -1.0 -2.5 0.9 1.7 0.4
Arm fat-free mass (left) 0.6 3.0 7.8 -2.4 -0.7 -2.0 -2.8 -1.3 -0.3 1.3
Number of operations (self-reported) 0.3 0.4 1.2 -0.8 -0.7 0.1 -0.5 0.3 0.6 1.1
Average weekly beer plus cider intake 0.4 0.5 2.6 -0.0 0.5 -1.6 -0.9 0.3 0.0 -0.1
Irritability 0.4 0.6 1.0 0.9 0.6 0.7 0.7 0.7 0.9 1.0
Risk taking 1.9 2.8 8.6 -1.3 -0.9 -2.4 -2.9 -0.2 -0.3 -1.5
Ever had prostate specific antigen (PSA) test 1.3 1.5 2.9 1.1 1.2 1.7 1.6 0.6 1.0 0.9
Fractured/broken bones in last 5 years 1.2 1.5 8.4 -0.1 -2.9 1.0 -0.5 -0.3 0.9 0.5
Age started oral contraceptive pill 1.9 2.3 3.8 -1.8 -0.0 -1.9 -1.1 -1.9 -1.8 -1.0
Diastolic blood pressure, automated reading 0.4 1.3 3.9 -0.8 -0.3 -2.0 -1.4 0.7 0.7 1.4
Ever depressed for a whole week 0.9 1.1 2.3 -1.2 -0.5 -1.5 -1.5 -0.7 -0.3 -0.9
Unable to work because of sickness or disability 1.5 1.9 3.8 -1.1 1.7 -1.9 -1.9 -0.8 -1.0 -0.3
Commuting to job workplace: Cycle 0.6 0.7 4.2 -0.5 0.6 -0.1 0.0 0.1 -0.4 2.0
Myopia 1.2 1.7 7.6 -0.4 -2.8 -0.1 -0.3 1.3 1.0 1.3
Vascular/heart problems diagnosed by doctor 0.5 1.3 2.9 0.7 -1.7 1.3 1.6 0.6 0.8 -0.3
Cholesterol lowering medication 1.0 1.5 3.5 1.9 1.8 0.8 1.1 1.1 0.8 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.9 -0.8 -0.6 -0.2 -1.4 -0.3 0.0 -0.7
Pain experienced in last month 0.4 0.6 2.1 0.7 -0.8 0.7 1.5 0.7 0.3 0.3
Supplements: Calcium 0.5 0.6 1.8 -0.8 -1.4 -0.2 -1.0 -0.5 -0.4 -0.1
Basal cell carcinoma (self-reported) 1.1 1.3 2.2 1.4 1.1 0.9 1.5 0.9 1.3 0.7
Heart attack/myocardial infarction (self-reported) 0.8 1.0 2.7 1.4 0.8 1.6 1.1 0.4 0.5 0.2
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.5 0.2 0.0 -0.5 -0.7 -0.6 -1.0 -1.2
Heart disease (siblings) 0.4 0.5 2.5 0.4 1.6 -0.5 0.2 0.0 0.3 -0.6
Alcohol drinker status: Previous 0.2 0.2 0.6 0.0 -0.2 -0.8 -0.1 -0.3 0.2 -0.8
Pack years of smoking 1.0 1.5 3.8 -1.5 -0.2 -1.3 -1.0 -1.9 -1.2 -0.4
Impedance of whole body 0.4 1.8 4.8 1.9 0.2 0.5 0.4 2.2 1.4 -1.3
Leg fat mass (left) 0.6 2.2 9.3 -1.2 0.8 -1.3 -3.0 0.5 1.3 0.6
Arm predicted mass (left) 0.6 2.9 6.4 -2.4 -0.9 -1.8 -2.5 -1.5 -0.5 1.2