Hub : Genes

B4GALT3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.2150	0.0600	6.3e-06	0.048	NA	0.113	NA	0.112	8.3e-05	NA	1.6e-09	NA	1.9e-09
2	GTEx	Artery Aorta	0.0820	0.0380	9.7e-03	0.016	NA	-0.003	NA	0.011	4.2e-02	NA	5.2e-01	NA	8.1e-02
3	GTEx	Cells Transformed fibroblasts	0.3100	0.0510	1.2e-13	0.276	NA	0.295	NA	0.273	8.3e-21	NA	2.0e-22	NA	1.4e-20
4	GTEx	Nerve Tibial	0.1382	0.0554	7.3e-03	0.037	NA	0.028	NA	0.035	1.2e-03	NA	4.4e-03	NA	1.5e-03
5	METSIM	Adipose	0.0494	0.0194	3.9e-04	0.025	0.020	0.036	0.027	0.037	8.8e-05	5.0e-04	3.2e-06	5.9e-05	2.7e-06
6	YFS	Blood	0.0366	0.0139	2.4e-05	0.022	0.015	0.014	0.018	0.022	9.7e-08	7.3e-06	1.5e-05	8.4e-07	7.3e-08
7	TCGA	Brain Lower Grade Glioma	0.0310	0.0170	2.9e-03	0.028	0.013	0.007	NA	0.014	3.4e-04	1.0e-02	4.8e-02	NA	8.4e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	2.6	4.2	12.4	-1.3	1.4	-1.6	-1.8	-1.6	-2.3	-3.5
Bipolar Disorder or Schizophrenia	2.1	5.1	12.3	-1.7	0.9	-2.1	-2.9	-1.7	-2.0	-3.5
Depressed Affect (Nagel 2018)	0.4	0.9	3.0	-1.1	1.7	-0.9	-0.6	-0.1	-0.6	-0.8
Depression (Nagel 2018)	0.9	1.4	4.5	0.8	2.1	0.1	0.5	1.5	1.4	0.4
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.6	-0.1	-0.7	-0.3	-0.1	0.7	0.5	0.8
Neuroticism (Nagel 2018)	0.2	0.6	1.8	-0.6	0.8	-0.5	0.0	-0.6	-0.7	-1.4
Schizophrenia (2018)	0.9	1.8	5.3	-1.2	0.1	-1.4	-2.3	-0.9	-0.8	-1.6
Schizophrenia vs Biploar Disorder	2.1	2.7	4.6	2.1	-1.5	1.9	1.3	1.7	1.8	0.9
Worry (Nagel 2018)	0.5	1.1	1.9	-1.3	0.2	-1.4	-0.9	-0.9	-1.0	-1.3
Alzheimer’s Disease (in mother)	7.7	9.0	13.2	-3.0	0.7	-3.6	-3.1	-2.8	-3.4	-3.3
Alzheimer’s Disease (in father)	4.4	4.8	7.0	-2.1	-1.5	-2.3	-1.9	-2.4	-2.4	-2.6
Alzheimer’s Disease (including proxy)	12.9	18.8	28.2	-4.7	-0.1	-5.3	-4.8	-4.2	-4.8	-4.3
Crohns Disease (2017)	1.6	3.6	9.1	1.8	3.0	1.5	1.2	0.4	0.0	-3.0
Irritable Bowel Disease (IBD)	2.1	4.9	14.4	1.8	3.6	0.6	1.3	-0.1	-1.3	-3.8
Ulcerative Colitis (UC)	2.1	4.0	11.4	1.1	3.4	-0.2	0.9	-0.7	-2.0	-3.1
Major Depression (MDD)	0.5	0.6	1.0	0.3	0.9	-1.0	-0.6	1.0	0.0	-1.0
Reaction Time	0.3	0.6	1.7	-0.7	0.1	-0.9	-1.3	0.1	-0.5	-1.1
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.7	-0.8	-0.8	-1.3	-0.3	0.1	-0.3	-0.2
Breast Cancer	0.4	1.0	1.9	0.8	1.2	0.3	0.7	1.4	0.8	1.3
Ovarian Cancer	0.7	0.9	3.2	0.7	0.5	1.8	0.2	0.9	1.2	0.5
Prostate Cancer	0.1	0.2	0.5	-0.2	0.7	0.3	-0.4	0.3	0.3	0.3
Age at First Birth	0.6	0.8	2.9	-0.7	-0.2	-0.3	0.0	-1.1	-1.7	-0.9
Bipolar Disorder (2011)	1.7	1.6	2.7	-1.4	0.4	-1.7	-1.0	-1.3	-1.4	-1.4
Body Mass Index (BMI) (2010)	0.5	0.7	1.5	0.8	0.3	0.9	0.3	0.9	1.2	1.0
Coronary Artery Disease (CAD)	0.9	1.0	2.0	-0.7	0.5	-1.4	-0.2	-1.2	-1.4	-0.9
Crohns Disease (2012)	0.7	1.1	2.5	1.1	1.4	1.1	0.8	0.1	-0.2	-1.6
Mean Putamen Volume	1.6	1.8	4.4	1.4	2.1	0.3	1.2	1.8	1.2	-0.5
Fasting Glucose	0.5	0.6	1.9	0.5	-0.0	0.9	0.6	0.8	-0.3	1.4
HbA1C	1.7	1.9	6.1	1.8	-1.1	2.5	1.3	0.7	0.8	-0.2
HDL Cholesterol	0.6	1.0	2.2	-0.3	-1.2	-1.1	0.5	-1.2	-1.5	-0.4
LDL Cholesterol	0.7	1.2	3.2	1.2	1.8	-0.1	1.5	-0.3	-0.8	-0.8
Lupus	5.0	7.6	19.2	-3.9	0.8	-2.9	-4.4	-2.1	-1.9	-1.3
Neuroticism (2016)	1.0	1.4	8.5	-0.3	-0.1	-0.5	-0.1	-0.4	-1.0	-2.9
Primary Biliary Cirrhosis	0.2	0.3	0.8	0.9	0.2	-0.5	0.3	0.8	0.8	0.1
Rheumatoid Arthritis	2.1	2.9	9.8	2.4	0.2	1.7	3.1	0.2	-0.3	-1.2
Schizophrenia (2014)	0.9	1.9	6.9	-1.6	-0.8	-1.4	-2.6	-0.6	-0.4	-0.9
Triglycerides	0.6	1.0	2.6	1.1	0.4	1.1	0.9	1.6	1.0	0.0
Type 2 Diabetes (T2D) (2012)	0.5	0.5	2.7	0.3	1.6	0.0	0.3	-0.5	-0.7	-0.5
Ulcerative Colitis	1.6	2.4	8.0	1.6	2.8	-0.1	0.8	0.8	-0.4	-2.2
Blood Eosinophil Count	3.0	22.9	43.0	6.3	-4.1	6.6	5.3	4.0	4.2	0.4
Blood Platelet Count	1.4	15.9	38.7	-6.2	-3.2	-4.0	-4.3	-3.9	-3.2	-1.7
Blood Red Count	1.3	12.7	32.9	5.7	0.0	3.8	4.1	3.4	3.4	1.2
Blood White Count	3.5	26.1	42.4	6.4	3.6	5.8	3.7	5.8	6.5	2.3
Heel T-Score	0.5	3.8	10.0	-1.3	1.0	-1.4	-1.6	-2.4	-2.0	-3.2
BMI	0.7	4.1	10.4	0.5	1.3	-0.3	-1.9	2.5	3.2	2.5
Height	0.1	2.4	4.3	-2.1	-2.0	-1.5	-2.0	-1.1	-0.8	-0.0
Waist Hip Ratio (WHR)	2.5	11.1	16.5	-3.3	-2.2	-3.5	-2.5	-3.5	-3.9	-4.1
Systolic Blood Pressure	0.4	2.0	9.5	0.4	0.2	0.3	0.0	1.6	1.3	3.1
Smoking Status	0.0	0.1	0.2	0.1	0.3	-0.2	0.3	0.3	-0.1	-0.5
Allergy or Eczema	4.9	12.9	38.4	4.3	-1.2	6.2	5.3	1.3	1.5	0.8
Cardiovascular Disease	0.3	0.8	2.6	1.0	1.6	-0.6	-0.6	0.7	0.8	0.7
Hypothyroidism (self reported)	1.0	2.2	6.7	-1.9	0.0	-1.1	-2.6	0.2	0.2	2.0
Respiratory disease	3.2	7.1	19.7	3.4	0.3	4.1	4.4	0.6	0.8	0.4
Type 2 Diabetes (T2D) (2018)	0.5	1.0	3.1	-1.2	0.3	-1.2	-1.8	-0.1	0.2	-1.0
Lung FEV1/FVC ratio	0.3	1.6	2.7	-1.0	1.4	-0.3	-1.6	1.5	1.0	-1.6
Lung FVC	0.3	1.3	3.7	1.0	1.9	-0.6	-0.2	1.8	0.6	-0.6
Neuroticism	0.5	1.1	4.4	-1.1	0.2	-1.0	-0.6	-0.8	-0.5	-2.1
Chronotype (morning person)	0.8	1.8	6.0	1.1	0.3	2.2	2.4	-0.4	-0.1	0.4
Hair Pigment	0.0	0.9	4.4	-0.5	2.1	-0.8	-0.2	0.1	-0.7	-0.4
Tanning	0.3	3.2	5.8	1.7	-1.1	1.4	1.5	2.2	2.4	1.7
Hand grip strength (left)	1.5	4.0	8.9	2.3	0.6	2.5	0.6	2.1	3.0	1.6
Number of treatments/medications taken	0.6	1.0	1.9	1.4	1.0	1.2	1.1	0.5	0.5	1.0
Average weekly spirits intake	0.6	0.8	1.9	0.3	-1.4	-0.2	0.9	-1.0	-1.0	-0.7
Sensitivity / hurt feelings	0.3	0.4	1.4	0.1	1.2	-1.0	0.3	-0.3	-0.3	-0.4
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.0	0.9	1.3	0.0	0.1	1.4	1.1	-1.0
Hearing difficulty/problems: Yes	1.3	1.9	3.7	1.2	1.3	1.1	0.2	1.7	1.9	1.6
Relative age of first facial hair	0.3	0.6	2.2	-0.9	-0.1	-0.5	-1.5	0.2	0.3	-0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	1.0	0.1	-0.2	0.4	0.3	-0.3	0.0	1.0
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.0	-0.6	1.4	-0.3	-1.3	0.6	1.0	0.0
Ever had hysterectomy (womb removed)	0.5	0.5	2.3	-0.2	1.5	-0.2	-0.6	0.6	0.6	0.3
Systolic blood pressure, automated reading	0.4	1.0	2.7	-0.6	0.6	-0.4	-1.3	1.0	1.0	1.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.7	0.1	0.8	0.3	-0.7	0.7	0.8	0.0
Angina	0.3	0.5	1.5	-0.6	-0.5	0.1	0.2	-1.2	-0.9	-0.4
Medication for hormone replacement therapy	0.5	0.5	2.0	-0.2	-0.4	1.0	-0.2	-0.6	-0.1	-1.4
Vitamin and mineral supplements	1.0	1.3	2.9	-0.6	-1.1	-1.3	0.1	-1.7	-1.7	-0.6
Supplements: Zinc	0.9	1.0	4.2	-1.4	-0.4	-0.8	-2.1	-0.5	0.0	-0.2
Medication: Co-codamol	0.4	0.5	1.3	0.6	1.1	-0.3	-0.8	0.1	0.6	-0.9
Medication: Metformin	1.0	1.4	3.6	-0.8	1.1	-1.2	-1.9	0.3	0.3	-1.7
Diabetes (father)	0.6	0.7	1.1	-0.8	-1.1	-1.0	-0.9	-0.5	-0.5	-0.9
Diabetes (mother)	1.8	2.4	4.0	-2.0	-0.6	-1.6	-1.5	-1.8	-1.9	-0.8
Severe depression (siblings)	1.1	1.3	2.7	-1.0	0.0	-1.0	-1.3	-1.0	-1.2	-1.6
Pack years adult smoking proportion	1.2	1.9	4.6	-1.4	-0.1	-1.5	-1.0	-2.1	-1.6	-0.6
Impedance of leg (right)	0.2	1.0	2.3	1.4	-0.5	0.4	0.2	1.4	0.6	-1.5
Leg fat-free mass (left)	0.6	2.9	8.0	-2.3	-0.4	-2.0	-2.8	-1.3	-0.6	0.9
Trunk fat percentage	0.8	3.2	8.3	-0.3	1.1	-1.1	-2.9	1.9	2.7	0.9
Hand grip strength (right)	1.2	3.1	9.4	1.5	1.0	1.7	-0.6	2.1	3.1	1.2
Townsend deprivation index at recruitment	0.3	0.4	2.6	0.3	-1.6	0.1	-0.2	0.2	0.5	0.1
Current tobacco smoking	0.4	0.6	1.6	0.1	0.0	-0.6	0.6	-0.7	-1.1	-1.3
Average weekly fortified wine intake	1.8	2.1	4.3	-1.2	1.4	-1.1	-0.8	-2.1	-1.8	-1.4
Maternal smoking around birth	0.3	0.5	0.9	-0.8	-0.9	-0.0	-0.2	-0.9	-0.5	-1.0
Fed-up feelings	0.7	1.2	2.2	-1.1	1.4	-1.5	-0.6	-0.4	-1.1	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	3.1	0.4	1.8	-0.3	-0.3	1.2	1.2	0.0
Relative age voice broke	1.3	2.0	3.3	-1.8	-1.6	-1.4	-1.8	-0.8	-0.6	-1.4
Taking other prescription medications	1.5	2.3	4.3	2.1	1.1	1.8	1.7	1.2	1.1	1.4
Age when periods started (menarche)	0.5	1.2	5.0	-0.1	-2.2	0.3	-0.8	-0.1	-0.2	-1.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.8	-0.9	0.4	0.1	-0.7	-0.2	-0.3	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	2.5	-0.0	1.6	0.2	-0.2	-0.8	-0.3	-1.0
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	3.8	-1.9	-1.9	-1.7	-1.8	-0.6	-0.4	0.1
Qualifications: CSEs or equivalent	0.1	0.2	0.4	-0.2	0.5	-0.3	-0.6	0.4	-0.3	0.2
Serious illness, injury or assault to yourself	0.5	0.7	2.2	0.6	-0.6	1.1	1.5	-0.1	0.6	0.3
High blood pressure	0.7	1.9	5.3	-1.0	1.7	-1.9	-2.3	-0.2	-0.3	0.6
Hayfever, allergic rhinitis or eczema	4.2	9.0	29.2	3.6	-1.3	5.4	3.9	1.2	1.6	0.7
Multivitamins +/- minerals	1.8	2.3	5.4	1.6	1.4	1.3	0.3	2.3	2.2	-0.1
Stomach or abdominal pain in last month	1.4	1.7	3.0	1.7	1.3	1.4	1.0	1.4	1.0	-1.3
Supplements: Glucosamine	0.5	0.6	3.2	-0.6	1.8	0.5	-0.5	-0.0	0.2	0.6
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	3.2	0.9	0.8	0.7	0.5	1.0	0.8	-1.8
Medication: Atenolol	0.6	0.7	2.3	-0.7	1.5	0.2	-0.5	-0.3	0.1	1.3
Medication: Levothyroxine sodium	1.1	1.9	4.6	-1.9	0.9	-0.7	-2.1	0.1	0.3	1.9
Sitting height	0.2	1.2	2.0	-1.4	-0.6	-1.4	-1.2	-1.2	-0.7	0.7
Chronic bronchitis/emphysema (father)	0.3	0.3	1.1	0.6	0.4	0.6	1.1	-0.4	-0.0	-0.4
High blood pressure (mother)	0.2	0.2	1.4	-0.2	-0.0	-0.1	0.2	0.0	0.4	1.2
Body mass index (BMI)	0.4	1.7	6.0	-1.0	0.8	-1.1	-2.4	0.4	1.3	1.2
Impedance of leg (left)	0.2	1.2	2.9	1.5	0.0	0.5	0.7	1.3	0.6	-1.7
Leg predicted mass (left)	0.5	2.8	7.7	-2.3	-0.4	-2.0	-2.8	-1.3	-0.6	0.9
Trunk fat mass	0.7	3.2	10.7	-0.9	0.9	-1.3	-3.3	1.3	2.2	1.1
Waist circumference	1.0	3.8	12.7	-2.4	0.2	-2.7	-3.6	-0.7	0.1	0.0
Number of incorrect matches in round	0.8	1.3	2.4	0.7	1.5	0.7	0.8	1.2	1.6	1.1
Past tobacco smoking	0.2	0.4	1.8	-0.1	-1.3	-0.1	0.7	-0.2	-0.4	0.0
Alcohol usually taken with meals	0.5	0.7	1.7	-0.7	-0.6	0.2	0.4	-1.1	-1.3	-1.2
Nervous feelings	1.2	2.3	6.0	-0.8	0.8	-2.1	-0.9	-1.2	-1.4	-2.4
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.0	0.6	1.6	-0.2	-0.7	1.7	1.5	-0.7
Hearing difficulty/problems with background noise	0.1	0.2	0.6	0.6	0.4	0.2	-0.3	0.1	0.2	-0.8
Hair/balding pattern: Pattern 2	0.6	0.7	2.5	-0.3	1.6	-0.3	-0.5	-0.1	0.6	1.3
Had menopause	0.9	1.1	3.0	-0.7	-0.5	-0.3	-0.2	-1.7	-1.1	-1.6
Had other major operations	0.3	0.4	1.5	-0.3	1.2	-0.3	-0.9	0.4	0.2	-0.1
Forced vital capacity (FVC)	0.2	0.9	3.3	1.2	-0.1	0.1	0.2	1.8	1.3	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	3.6	0.0	1.9	0.5	0.0	-0.2	0.2	-0.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.5	0.1	1.2	-0.1	0.1	0.2	0.4	-0.8
Qualifications: None of the above	0.3	0.6	2.4	-0.6	-1.0	0.0	-0.4	-0.2	0.4	1.6
Financial difficulties in last 2 years	1.7	2.3	6.2	-1.0	1.3	-2.5	-2.2	-0.6	-1.1	-0.9
Mouth/teeth dental problems	2.6	3.9	8.6	-1.0	0.1	-1.9	-2.9	2.0	2.1	2.4
Heart attack	1.4	1.8	5.2	1.9	0.6	2.3	1.6	0.7	0.9	0.4
Allergy	4.3	9.8	29.4	-4.1	0.6	-5.4	-4.4	-1.1	-1.2	0.2
Pain all over the body in last month	1.3	1.4	3.8	0.0	2.0	-0.8	-1.4	1.2	1.4	0.2
Diabetes (self-reported)	0.3	0.5	1.5	0.6	0.1	0.1	-0.4	1.2	1.1	-0.4
Hayfever/allergic rhinitis (self-reported)	5.6	7.4	21.6	3.2	-1.9	4.6	4.0	-0.5	0.2	-0.4
Medication: Ramipril	2.1	2.7	9.2	1.0	0.9	0.6	-0.6	3.0	2.3	1.3
Medication: Simvastatin	1.8	2.6	6.1	2.5	2.3	0.7	0.9	1.6	1.2	-1.2
Fluid intelligence score	0.3	0.6	1.4	-0.8	-1.2	-1.0	-0.4	0.0	-0.5	0.5
Illnesses of siblings	0.9	1.3	5.6	-0.7	-2.4	0.3	1.1	-0.7	-1.0	0.2
Neuroticism score	0.2	0.4	1.2	-0.3	1.1	-0.7	-0.0	-0.0	0.1	-0.8
Weight	0.5	2.5	9.3	-1.7	0.1	-1.6	-3.1	-0.2	0.9	1.3
Impedance of arm (right)	0.2	1.1	2.6	1.2	0.6	-0.0	-0.1	1.6	1.0	-1.5
Arm fat percentage (right)	0.8	3.1	6.9	-0.3	1.7	-0.8	-2.6	1.8	2.6	0.9
Trunk fat-free mass	0.7	3.7	7.6	-2.8	-1.1	-2.0	-2.6	-2.0	-1.3	0.7
Hip circumference	0.4	1.9	5.4	-0.9	0.1	-0.8	-2.3	0.5	1.6	1.8
Time employed in main current job	0.4	0.5	1.3	1.1	-0.4	-0.3	0.2	0.8	0.9	-0.7
Alcohol intake versus 10 years previously	0.4	0.7	1.4	0.4	1.2	0.1	-0.7	1.2	1.1	-0.1
Father’s age at death	0.5	0.6	1.8	0.4	0.0	0.1	1.0	-0.7	-1.3	-1.0
Worrier / anxious feelings	0.1	0.2	0.4	-0.4	0.6	-0.6	-0.5	-0.1	0.3	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	3.4	0.5	1.3	-0.2	-0.3	1.9	1.9	0.8
Falls in the last year	0.5	0.7	2.1	-0.2	-1.4	-0.4	-0.9	-0.5	-0.1	-1.3
Hair/balding pattern: Pattern 3	0.5	0.7	1.5	0.5	-0.4	1.0	1.2	0.0	-0.7	-1.2
Number of live births	0.5	0.7	1.2	-1.1	-0.6	-0.4	-1.0	-1.1	-0.8	-0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	3.2	0.5	0.1	-0.1	-0.3	1.8	1.3	-0.2
Pulse rate	0.2	0.4	1.3	0.6	-0.7	-0.3	0.3	-0.3	0.1	-1.2
Happiness	0.2	0.2	0.8	0.1	0.9	-0.3	0.2	0.5	0.5	-0.2
Noisy workplace	2.1	2.6	6.0	1.6	0.5	1.3	0.7	2.3	2.4	1.3
Qualifications: A levels/AS levels or equivalent	0.9	1.9	6.0	-0.6	0.0	-1.0	-0.1	-1.0	-2.3	-2.5
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.0	-0.2	-0.8	-1.1	-0.8	0.1	-0.3	-1.4
Mouth/teeth dental problems: Dentures	4.8	8.0	24.5	2.9	0.3	5.0	4.1	1.3	1.9	1.0
Asthma	4.2	8.3	20.4	3.7	-0.6	4.5	4.4	1.2	1.4	0.8
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	3.8	0.8	-1.2	0.8	-0.1	1.0	1.3	2.0
Medication: Cholesterol lowering	1.5	2.3	7.8	1.9	2.8	1.0	1.1	1.0	1.0	-0.6
Depression (self-reported)	1.0	1.2	5.9	0.5	2.4	-0.1	0.6	0.4	0.8	-0.9
Medication: Lansoprazole	0.2	0.2	0.5	0.1	-0.7	-0.5	0.1	0.7	0.2	0.1
Prospective memory result	0.9	1.1	2.9	1.6	0.3	1.1	1.7	0.5	1.0	0.0
Lung cancer (father)	0.1	0.2	0.6	-0.8	-0.2	0.4	-0.4	-0.1	0.3	0.4
Illnesses of mother	1.4	1.8	3.1	1.0	-0.3	1.4	1.5	1.4	1.8	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.9	-0.1	-0.3	-0.7	-1.4	1.2	1.0	-0.7
Pulse wave Arterial Stiffness index	0.3	0.4	1.3	-0.1	0.3	-0.2	-0.4	-0.9	-0.6	-1.1
Impedance of arm (left)	0.3	1.2	3.5	1.4	0.6	0.4	0.0	1.9	1.2	-1.1
Arm fat mass (right)	0.7	2.8	10.1	-1.1	0.6	-1.3	-3.2	1.0	1.9	1.2
Trunk predicted mass	0.6	3.7	7.6	-2.8	-1.1	-2.0	-2.6	-2.0	-1.3	0.6
Standing height	0.2	2.4	4.4	-2.1	-1.6	-1.7	-1.9	-1.4	-1.1	0.1
Length of working week for main job	0.6	0.6	2.2	0.7	-1.0	0.1	0.2	0.9	1.5	-0.0
Exposure to tobacco smoke at home	1.8	2.0	5.7	0.4	-1.1	0.3	-0.7	1.7	2.4	1.9
Breastfed as a baby	0.7	0.9	3.1	-0.6	-0.8	-1.7	-1.2	0.4	0.3	-0.4
Tense / ‘highly strung’	0.8	1.3	3.9	-1.0	0.3	-1.9	-2.0	-0.6	-0.1	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	2.9	0.4	1.7	-0.5	0.9	-0.3	-0.6	-0.6
Hair/balding pattern: Pattern 4	0.3	0.8	1.8	1.1	0.4	0.2	1.4	1.2	0.8	0.6
Birth weight of first child	2.9	5.2	10.4	-3.2	-0.2	-2.0	-3.2	-2.1	-1.8	-2.0
Peak expiratory flow (PEF)	0.6	1.4	3.0	1.2	0.7	1.6	1.7	0.9	0.8	0.8
Pulse wave reflection index	0.3	0.4	1.8	-0.7	0.5	-0.4	-1.3	-0.2	0.1	-0.0
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	-0.2	0.2	-0.3	-0.2	-0.0	0.1	0.2
Loud music exposure frequency	0.1	0.1	0.2	0.1	-0.4	-0.1	-0.4	-0.1	-0.2	0.2
Qualifications: O levels/GCSEs or equivalent	1.7	2.8	7.4	-1.9	1.7	-2.7	-2.2	0.1	-0.7	-0.0
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	4.1	0.2	-0.4	-0.6	1.4	-2.0	-2.0	-1.9
Blood clot in the leg (DVT)	0.4	0.5	1.6	0.3	-0.1	-0.5	-0.5	-0.6	-1.0	-1.2
Medication: Paracetamol	0.8	1.3	2.6	-0.2	-0.3	-0.6	-1.6	1.6	1.5	1.1
Headache pain in last month	0.6	1.0	2.5	0.6	1.2	0.5	-0.5	1.5	1.6	0.5
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	9.7	-1.3	-3.1	-0.3	-0.1	-0.8	-0.6	-0.2
Glaucoma (self-reported)	0.2	0.2	0.6	0.1	-0.6	0.1	-0.8	-0.2	0.2	-0.6
Gout (self-reported)	0.4	0.6	1.2	1.1	-0.0	1.1	1.1	-0.2	-0.2	-0.7
Hypothyroidism/myxoedema (self-reported)	1.4	2.8	7.9	-2.0	1.0	-1.1	-2.8	0.4	0.5	2.2
Medication: Amlodipine	0.3	0.4	1.2	-0.4	1.1	0.2	-0.7	-0.4	0.5	0.6
Medication: Ventolin 100micrograms inhaler	2.9	3.7	13.7	2.0	-1.0	3.7	2.4	0.1	1.2	0.5
Birth weight	0.8	1.7	3.8	-1.0	-1.0	0.3	-1.7	0.4	1.8	1.9
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.8	1.3	-0.9	0.6	0.0	1.3	0.8	-0.7
High blood pressure (siblings)	1.1	1.6	7.0	0.2	2.7	-0.4	-1.8	0.2	1.0	0.5
Forced vital capacity (FVC), Best measure	0.2	0.7	2.1	0.7	-0.3	-0.3	-0.8	1.4	1.3	0.1
Body fat percentage	0.8	3.1	8.6	-0.4	1.4	-1.0	-2.9	1.7	2.6	0.7
Leg fat percentage (right)	0.6	2.0	6.4	-0.4	1.2	-0.8	-2.5	1.2	1.9	0.6
Arm fat-free mass (right)	0.6	2.9	5.9	-2.3	-1.1	-1.8	-2.4	-1.7	-0.9	0.9
Exposure to tobacco smoke outside home	0.7	0.9	3.0	-0.8	-0.1	-0.6	-1.2	0.6	0.5	1.7
Comparative body size at age 10	1.3	3.5	9.1	0.2	2.0	0.5	-0.8	2.6	3.0	1.9
Number of full brothers	0.2	0.3	0.9	0.8	-0.5	-0.4	0.1	0.0	-0.0	-0.9
Worry too long after embarrassment	1.0	1.7	3.0	-1.4	-0.8	-1.4	-1.2	-1.7	-1.5	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	5.3	-0.8	0.7	-1.9	-0.3	-2.3	-2.3	-1.4
Wheeze or whistling in the chest in last year	1.6	2.9	5.5	1.7	-2.4	2.1	2.1	1.1	1.1	0.7
Number of children fathered	1.6	1.8	3.8	0.8	1.6	1.1	0.7	1.0	1.7	2.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	2.2	0.1	0.3	-0.4	-0.6	1.5	0.8	0.5
Age at first live birth	0.4	0.7	2.0	0.0	-0.7	0.0	0.9	-0.6	-1.4	-0.9
Pulse wave peak to peak time	0.2	0.3	1.4	-0.1	-0.2	0.0	0.2	0.6	0.4	1.2
Health satisfaction	0.6	0.7	3.1	-0.6	0.3	-1.8	-1.1	0.5	0.1	-0.2
Shortness of breath walking on level ground	0.3	0.4	0.7	-0.9	-0.5	-0.8	-0.7	-0.6	-0.5	-0.1
Qualifications: College or University degree	0.5	1.4	3.2	1.0	-0.9	0.7	1.7	-0.7	-1.1	-1.8
Eye problems/disorders: None of the above	0.5	0.6	3.3	-0.1	-1.8	-0.6	-0.2	0.8	0.2	-0.2
Mouth/teeth dental problems: Loose teeth	2.7	3.2	8.6	2.3	-0.0	2.9	2.6	0.2	0.8	1.1
Emphysema/chronic bronchitis	0.7	0.8	2.5	0.1	1.6	-0.3	-0.1	-0.6	-1.1	-1.3
Medication for pain relief, constipation, heartburn	0.7	1.1	2.9	-0.8	-0.3	-0.8	0.6	-1.7	-1.6	-1.0
Neck or shoulder pain in last month	0.3	0.4	0.9	-0.7	-1.0	0.9	-0.4	-0.3	0.5	0.4
Medication: Blood pressure	0.7	1.2	5.1	0.8	2.3	0.2	0.1	0.5	0.3	1.6
Angina (self-reported)	0.4	0.6	1.7	-1.0	-0.4	-0.2	-0.2	-1.3	-1.0	-0.2
Migraine (self-reported)	0.5	0.6	1.4	-0.8	-0.1	-0.7	-1.2	-1.0	-0.5	0.6
Medication: Ibuprofen	0.8	0.9	2.5	0.8	-1.2	0.5	0.2	0.8	0.9	1.6
Medication: Allopurinol	0.2	0.3	1.1	1.0	0.4	0.6	0.8	0.3	0.0	-0.0
Medication: Omeprazole	0.5	0.6	1.3	-0.8	-0.6	-0.4	-1.0	-0.9	-0.6	-1.1
Medication: Seretide 50 evohaler	1.6	1.8	3.9	1.1	-0.7	1.5	0.2	1.6	2.0	1.5
Mean time to correctly identify matches	0.3	0.5	1.0	-0.8	0.2	-0.5	-0.5	-0.6	-1.0	-1.0
Heart disease (mother)	0.2	0.3	0.7	0.3	-0.8	-0.4	-0.2	-0.6	-0.9	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	0.1	0.1	0.4	0.2	0.1	0.2	0.3
Whole body fat mass	0.7	3.0	11.4	-1.2	0.7	-1.6	-3.4	0.9	1.8	0.9
Leg fat mass (right)	0.6	2.3	9.7	-1.2	0.8	-1.4	-3.1	0.5	1.4	0.6
Arm predicted mass (right)	0.6	3.1	6.8	-2.4	-0.9	-1.9	-2.6	-1.8	-1.0	0.5
Pulse rate, automated reading	0.3	0.9	4.9	0.2	-2.2	-0.6	-0.5	-0.2	-0.0	-0.9
Alcohol intake frequency.	0.1	0.3	0.7	0.2	-0.6	-0.3	-0.8	0.3	0.5	-0.6
Comparative height size at age 10	0.1	0.8	2.0	-0.2	1.3	-0.9	-0.7	-0.4	0.2	1.4
Number of full sisters	0.5	0.6	3.0	-0.1	-0.1	-0.9	-1.7	-0.0	0.5	0.3
Suffer from ‘nerves’	0.9	1.5	2.9	-1.2	1.6	-1.7	-1.7	-0.3	-0.2	-0.8
Overall health rating	0.6	1.3	3.0	0.4	1.1	0.3	-1.1	1.0	1.7	1.6
Chest pain or discomfort	0.7	1.0	2.2	-0.9	-1.5	-0.5	-1.2	-1.1	-0.9	-0.6
Had major operations	0.2	0.2	0.8	-0.6	-0.9	-0.2	-0.5	-0.4	0.2	0.2
Age at last live birth	0.9	1.3	3.0	-0.2	-1.7	-0.6	0.5	-1.1	-1.5	-1.3
Family relationship satisfaction	0.9	1.1	1.8	0.0	0.8	-1.3	-1.0	1.3	1.2	1.1
Leg pain on walking	0.8	1.0	1.8	-0.4	1.0	-1.3	-1.1	-0.6	-1.0	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.0	-0.2	-0.8	0.2	0.5	-0.5	-0.2	1.0
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.2	0.5	1.1	0.6	0.1	0.6	0.8	-0.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.2	-1.1	0.5	-0.6	-0.7	-0.5	-0.5	0.8
Medication: Aspirin	1.2	1.6	3.6	1.6	0.9	1.9	1.3	0.8	0.8	1.0
Supplements: Vitamin C	1.3	1.5	3.7	-1.8	-0.4	-0.7	-1.7	-0.3	-0.0	1.9
Knee pain experienced in last month	0.6	1.0	2.6	-1.0	-0.7	-0.2	0.0	-1.4	-1.6	0.8
Hypertension (Self-reported)	0.6	1.7	4.2	-0.8	1.9	-1.8	-2.0	-0.2	-0.3	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.4	0.4	-0.7	0.9	0.8	0.1	0.7	1.6
Illnesses of father: Heart disease	0.6	0.9	1.8	0.4	-1.0	0.3	1.1	-1.3	-1.1	-0.8
Illnesses of siblings: Diabetes	0.9	1.1	2.7	0.0	0.7	-1.6	-1.6	1.1	0.7	-0.2
Smoking status: Previous	0.2	0.2	1.2	0.1	1.1	0.6	-0.4	-0.1	0.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.3	0.0	-0.6	-0.7	-1.1	0.8	0.7	0.9
Whole body fat-free mass	0.6	3.3	6.9	-2.5	-0.8	-2.0	-2.6	-1.8	-1.0	0.8
Leg fat-free mass (right)	0.5	2.7	6.4	-2.3	-0.4	-1.9	-2.5	-1.4	-0.6	0.9
Arm fat percentage (left)	0.7	3.0	7.6	-0.3	1.5	-0.7	-2.8	1.8	2.5	0.9
Average weekly red wine intake	0.5	0.8	2.7	0.6	-1.6	0.6	1.2	-0.3	-0.2	-0.4
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.4	-1.0	-1.1	-1.2	-0.9	-0.8	-0.8	0.3
Mood swings	0.3	0.5	1.3	0.4	1.1	-0.1	0.8	-0.0	-0.4	-1.1
Loneliness, isolation	0.5	0.6	3.9	-0.2	2.0	0.1	-0.4	-0.1	0.1	0.6
Long-standing illness, disability or infirmity	0.8	1.3	2.9	1.7	1.5	0.3	0.3	1.2	1.1	1.0
Ever had bowel cancer screening	1.6	1.9	11.9	0.9	3.5	-0.6	0.4	0.3	0.1	-0.3
Diabetes diagnosed by doctor	0.4	0.7	2.1	-0.5	0.3	-0.9	-1.4	0.7	0.6	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	0.5	0.1	0.2	0.9	0.3	0.0	-0.2
Friendships satisfaction	0.5	0.6	1.8	-0.7	0.3	-1.3	-0.8	0.4	-0.1	1.0
Qualifications: nursing, teaching	0.8	1.3	5.2	0.6	2.3	-0.2	0.3	0.3	0.0	-1.8
Commuting to job workplace: Walk	0.3	0.3	0.7	0.5	-0.6	0.9	0.6	0.4	0.0	-0.5
Eye problems/disorders: Cataract	0.9	1.0	5.4	0.0	2.3	0.7	0.2	-0.9	-0.5	-0.4
Mouth/teeth dental problems: Mouth ulcers	6.2	9.8	21.0	-2.7	-1.2	-1.9	-0.9	-3.9	-4.6	-4.4
Medication for cholesterol	0.2	0.4	0.5	-0.4	-0.7	-0.7	0.3	-0.7	-0.6	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.3	1.3	1.2	1.8	1.0	0.9	1.2	0.4
Back pain experienced in last month	0.7	1.0	3.1	-0.7	-0.9	-0.1	-0.9	-1.8	-1.0	-1.0
Mineral and other dietary supplements	0.7	0.9	2.7	0.1	-0.1	-1.6	0.3	-0.6	-1.3	-1.1
Breast cancer (self-reported)	0.4	0.5	1.3	-0.6	-1.1	0.3	1.1	-0.4	-0.3	0.4
Asthma (self-reported)	4.3	8.7	21.1	3.7	-0.8	4.6	4.5	1.3	1.6	1.0
Osteoporosis (self-reported)	1.6	2.0	6.3	-0.9	2.5	-0.3	-1.5	0.9	1.1	1.6
Osteoarthritis (self-reported)	0.5	0.7	1.7	-1.0	1.0	-0.5	-0.7	-1.3	-0.3	0.5
Medication: Aspirin	0.8	1.0	3.0	1.2	-0.1	1.7	1.6	0.1	0.1	0.5
Medication: Gliclazide	0.6	0.7	1.5	-0.4	0.2	-1.2	-1.0	0.6	1.2	0.4
Illnesses of father: None of the above (group 1)	0.5	0.6	1.5	-1.2	-0.5	-0.5	-1.0	0.8	0.5	0.5
Smoking status: Current	0.2	0.3	0.9	0.3	0.1	-0.3	0.8	-0.4	-0.6	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	6.6	0.7	0.0	0.1	-0.7	2.6	1.9	-0.1
Whole body water mass	0.6	3.4	7.5	-2.6	-0.9	-2.0	-2.7	-1.7	-1.0	0.9
Leg predicted mass (right)	0.5	2.6	6.2	-2.3	-0.4	-1.9	-2.5	-1.4	-0.6	1.0
Arm fat mass (left)	0.7	3.0	10.6	-1.1	0.9	-1.4	-3.3	1.1	2.0	1.2
Number of self-reported non-cancer illnesses	0.5	0.9	1.7	1.2	1.1	0.9	1.3	-0.5	-0.5	0.6
Average weekly champagne plus white wine intake	0.3	0.4	1.0	-1.0	0.5	-0.4	-0.8	-0.4	-0.3	-1.0
Miserableness	0.7	1.3	3.6	-0.6	1.9	-1.4	-0.8	0.4	-0.4	-1.5
Guilty feelings	0.7	1.1	3.0	1.3	-0.4	1.3	1.7	-0.2	0.4	-1.0
Wears glasses or contact lenses	2.2	2.6	5.9	-1.7	0.9	-1.5	0.0	-2.2	-2.4	-1.1
Ever taken oral contraceptive pill	1.8	2.0	3.8	1.6	1.8	1.0	0.5	1.9	1.8	-0.3
Hearing aid user	2.2	2.5	5.8	-2.4	1.6	-0.8	-1.8	-1.5	-1.4	-1.0
Mother’s age at death	0.4	0.5	1.2	-1.0	-0.8	-0.1	-0.4	-0.3	-0.1	-1.1
Financial situation satisfaction	0.7	0.9	3.5	-0.3	-1.1	-1.9	-1.2	0.4	0.3	-0.1
Tinnitus: Yes, now most or all of the time	3.2	3.8	6.6	1.6	0.9	1.9	0.9	2.4	2.5	2.6
Commuting to job workplace: Public transport	0.3	0.3	1.2	0.0	-0.9	0.2	-0.1	0.3	-0.2	-1.1
Eye problems/disorders: Glaucoma	0.2	0.2	0.8	0.1	-0.4	0.1	-0.2	-0.9	-0.3	-0.6
Medication: Blood pressure	0.5	0.9	2.8	-0.4	1.7	-0.1	-1.3	0.9	0.9	-0.1
Pain type(s) experienced in last month: Hip pain	1.2	1.5	4.6	-0.5	-0.7	0.7	0.5	-2.1	-1.6	-1.5
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.3	-0.4	-0.9	1.5	-0.5	0.1	0.9	0.5
High cholesterol (Self-reported)	1.1	1.9	8.5	1.4	2.9	0.3	0.3	1.1	1.1	-0.7
Medication: Bendroflumethiazide	0.9	1.3	5.8	-0.2	2.4	-0.3	-1.1	1.0	1.0	0.2
Medication: Paracetamol	0.4	0.6	1.6	-0.2	-0.2	-0.2	-0.6	1.2	1.1	1.1
Medication: Lisinopril	1.0	1.3	3.2	-0.2	1.6	-0.7	-0.6	-1.0	-1.3	-1.8
Medication: Atorvastatin	1.2	1.5	3.1	1.4	1.8	1.5	1.7	0.2	0.4	0.2
Illnesses of father: High blood pressure	0.9	1.1	3.3	0.9	1.8	-1.0	-1.0	1.0	0.7	0.2
Alcohol drinker status: Never	1.0	1.3	3.0	-1.1	-1.7	-1.3	-1.6	0.0	-0.4	-0.4
Ever smoked	0.3	0.4	1.5	0.2	1.2	0.1	-0.8	0.5	0.6	-0.4
Basal metabolic rate	0.5	3.0	8.4	-2.4	-0.6	-1.9	-2.9	-1.3	-0.4	1.1
Leg fat percentage (left)	0.5	1.9	6.3	-0.6	1.4	-1.0	-2.5	0.9	1.7	0.4
Arm fat-free mass (left)	0.6	3.0	7.8	-2.4	-0.7	-2.0	-2.8	-1.3	-0.3	1.3
Number of operations (self-reported)	0.3	0.4	1.2	-0.8	-0.7	0.1	-0.5	0.3	0.6	1.1
Average weekly beer plus cider intake	0.4	0.5	2.6	-0.0	0.5	-1.6	-0.9	0.3	0.0	-0.1
Irritability	0.4	0.6	1.0	0.9	0.6	0.7	0.7	0.7	0.9	1.0
Risk taking	1.9	2.8	8.6	-1.3	-0.9	-2.4	-2.9	-0.2	-0.3	-1.5
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.9	1.1	1.2	1.7	1.6	0.6	1.0	0.9
Fractured/broken bones in last 5 years	1.2	1.5	8.4	-0.1	-2.9	1.0	-0.5	-0.3	0.9	0.5
Age started oral contraceptive pill	1.9	2.3	3.8	-1.8	-0.0	-1.9	-1.1	-1.9	-1.8	-1.0
Diastolic blood pressure, automated reading	0.4	1.3	3.9	-0.8	-0.3	-2.0	-1.4	0.7	0.7	1.4
Ever depressed for a whole week	0.9	1.1	2.3	-1.2	-0.5	-1.5	-1.5	-0.7	-0.3	-0.9
Unable to work because of sickness or disability	1.5	1.9	3.8	-1.1	1.7	-1.9	-1.9	-0.8	-1.0	-0.3
Commuting to job workplace: Cycle	0.6	0.7	4.2	-0.5	0.6	-0.1	0.0	0.1	-0.4	2.0
Myopia	1.2	1.7	7.6	-0.4	-2.8	-0.1	-0.3	1.3	1.0	1.3
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.9	0.7	-1.7	1.3	1.6	0.6	0.8	-0.3
Cholesterol lowering medication	1.0	1.5	3.5	1.9	1.8	0.8	1.1	1.1	0.8	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.9	-0.8	-0.6	-0.2	-1.4	-0.3	0.0	-0.7
Pain experienced in last month	0.4	0.6	2.1	0.7	-0.8	0.7	1.5	0.7	0.3	0.3
Supplements: Calcium	0.5	0.6	1.8	-0.8	-1.4	-0.2	-1.0	-0.5	-0.4	-0.1
Basal cell carcinoma (self-reported)	1.1	1.3	2.2	1.4	1.1	0.9	1.5	0.9	1.3	0.7
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.7	1.4	0.8	1.6	1.1	0.4	0.5	0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.5	0.2	0.0	-0.5	-0.7	-0.6	-1.0	-1.2
Heart disease (siblings)	0.4	0.5	2.5	0.4	1.6	-0.5	0.2	0.0	0.3	-0.6
Alcohol drinker status: Previous	0.2	0.2	0.6	0.0	-0.2	-0.8	-0.1	-0.3	0.2	-0.8
Pack years of smoking	1.0	1.5	3.8	-1.5	-0.2	-1.3	-1.0	-1.9	-1.2	-0.4
Impedance of whole body	0.4	1.8	4.8	1.9	0.2	0.5	0.4	2.2	1.4	-1.3
Leg fat mass (left)	0.6	2.2	9.3	-1.2	0.8	-1.3	-3.0	0.5	1.3	0.6
Arm predicted mass (left)	0.6	2.9	6.4	-2.4	-0.9	-1.8	-2.5	-1.5	-0.5	1.2