TWAS hub - NDUFS2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1070	0.0330	2.8e-05	0.093	0.053	0.104	0.101	0.109	1.9e-11	4.7e-07	1.1e-12	2.9e-12	3.4e-13
2	GTEx	Adipose Subcutaneous	0.0590	0.0260	5.9e-03	0.087	NA	0.062	NA	0.071	1.3e-07	NA	8.6e-06	NA	2.0e-06
3	GTEx	Artery Tibial	0.0777	0.0371	9.5e-03	0.018	NA	0.016	NA	0.026	1.4e-02	NA	1.8e-02	NA	3.5e-03
4	GTEx	Cells Transformed fibroblasts	0.1130	0.0440	3.9e-03	0.066	NA	0.083	NA	0.096	1.0e-05	NA	8.7e-07	NA	1.2e-07
5	GTEx	Esophagus Muscularis	0.1060	0.0450	6.4e-03	0.088	NA	0.037	NA	0.050	5.1e-06	NA	2.5e-03	NA	5.3e-04
6	GTEx	Skin Not Sun Exposed Suprapubic	0.1270	0.0510	2.1e-03	0.089	NA	0.039	NA	0.050	1.4e-05	NA	3.4e-03	NA	9.6e-04
7	GTEx	Skin Sun Exposed Lower leg	0.0770	0.0250	2.2e-04	0.040	NA	0.044	NA	0.055	2.7e-04	NA	1.5e-04	NA	2.4e-05
8	GTEx	Testis	0.2360	0.0760	1.3e-03	0.022	NA	0.037	NA	0.072	3.4e-02	NA	9.6e-03	NA	4.1e-04
9	METSIM	Adipose	0.1007	0.0333	3.1e-06	0.015	0.047	0.038	0.045	0.035	2.2e-03	1.3e-07	2.1e-06	2.5e-07	4.9e-06
10	NTR	Blood	0.0214	0.0090	1.1e-03	0.022	0.008	0.015	0.018	0.024	9.7e-08	8.3e-04	1.0e-05	1.2e-06	2.0e-08
11	TCGA	Brain Lower Grade Glioma	0.0951	0.0348	2.5e-07	0.043	0.059	0.066	NA	0.060	1.2e-05	2.6e-07	5.2e-08	NA	2.2e-07
12	TCGA	Prostate Adenocarcinoma	0.0428	0.0215	4.3e-03	0.009	0.009	0.001	NA	0.006	3.8e-02	3.7e-02	2.1e-01	NA	6.9e-02
13	TCGA	Thyroid Carcinoma	0.2400	0.0880	9.9e-08	0.047	0.082	0.067	NA	0.054	2.2e-05	2.1e-08	4.1e-07	NA	5.7e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Alzheimer’s Disease (including proxy)	9.6	14.0	29.6	-4.5	-5.4	-3.5	-3.6	-4.1	-3.1	-3.2	-3.3	-3.3	-4.1	-5.1	-1.6	-1.6
Mouth/teeth dental problems: Mouth ulcers	7.0	11.2	27.0	-3.4	-5.2	-3.8	-2.1	-4.4	-3.8	-4.5	-2.9	-1.0	-3.2	-3.8	-1.2	0.0
Alzheimer’s Disease (in mother)	6.4	7.5	15.5	-3.6	-3.8	-2.4	-2.3	-3.2	-2.1	-2.2	-2.7	-2.5	-3.1	-3.9	-0.6	-0.9
Alzheimer’s Disease (in father)	4.9	5.3	8.4	-2.2	-2.9	-2.8	-2.0	-2.7	-2.5	-2.6	-2.2	-1.0	-1.9	-2.8	-1.6	-1.8
Bipolar Disorder (2018)	4.8	7.6	14.8	-2.3	-3.5	-3.7	-1.4	-3.5	-3.4	-3.1	-3.2	-1.6	-1.6	-3.9	-1.3	-1.1
Asthma	4.6	9.1	24.4	4.3	1.9	2.6	4.9	1.3	1.5	1.1	2.1	2.6	4.9	3.0	2.5	3.0
Asthma (self-reported)	4.6	9.1	23.0	4.2	2.0	2.7	4.8	1.5	1.7	1.3	2.3	2.6	4.8	3.0	2.5	3.0
Medication: Ventolin 100micrograms inhaler	4.2	5.3	13.0	2.3	1.3	0.9	3.6	0.4	1.4	1.4	2.6	3.2	2.9	1.3	2.8	3.0
Tinnitus: Yes, now most or all of the time	4.2	4.9	6.5	2.5	2.5	2.0	1.8	2.5	2.2	2.5	2.3	2.3	2.5	2.4	1.3	1.4
Mouth/teeth dental problems: Dentures	4.0	6.7	20.9	4.3	2.6	1.6	3.8	1.2	0.4	0.3	1.7	2.9	4.6	3.1	1.1	0.5
Respiratory disease	3.7	8.1	21.9	3.9	1.7	2.5	4.7	0.9	1.4	1.0	2.0	2.9	4.5	3.2	2.3	2.7
Number of children fathered	3.6	4.0	9.2	0.3	1.4	2.2	0.2	1.9	3.0	3.0	1.7	1.8	0.1	2.5	2.0	2.7
Seen a psychiatrist for nerves, anxiety, tension or depression	3.5	4.5	6.6	-2.3	-2.5	-1.7	-2.5	-1.3	-1.6	-2.0	-1.7	-2.2	-2.5	-2.6	-2.2	-2.1
Bipolar Disorder or Schizophrenia	3.3	8.1	13.0	-2.3	-3.5	-3.1	-1.9	-3.4	-3.6	-3.2	-3.5	-2.6	-1.4	-3.6	-1.3	-1.9
Medication: Atenolol	3.1	3.9	11.4	1.4	-0.2	2.3	0.4	1.4	2.4	2.1	2.6	1.8	1.2	1.6	2.5	3.4
Supplements: Vitamin C	3.1	3.6	9.8	0.5	0.1	1.5	-0.2	1.8	3.1	2.6	3.1	1.5	-0.0	1.5	2.4	2.2
Headache pain in last month	3.0	5.1	13.4	0.9	1.6	2.5	2.7	0.7	2.6	2.7	2.5	2.3	1.6	1.7	3.7	2.2
Waist Hip Ratio (WHR)	2.9	13.0	24.3	-2.9	-4.9	-3.6	-2.8	-3.8	-4.3	-4.4	-4.3	-2.7	-2.7	-4.3	-3.4	-0.2
Allergy or Eczema	2.9	7.6	23.3	4.7	1.9	1.5	4.7	1.3	-0.2	-0.9	2.3	2.8	4.8	2.8	0.9	0.4
Medication: Levothyroxine sodium	2.8	4.8	12.0	-0.1	0.7	1.6	0.5	1.6	3.5	3.1	3.1	3.3	-0.6	1.4	2.8	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.6	3.1	6.1	1.9	0.8	0.4	1.1	1.2	2.3	1.8	2.3	1.3	1.9	1.9	2.0	2.5
Hayfever, allergic rhinitis or eczema	2.5	5.4	16.3	3.6	1.8	1.5	4.0	1.1	0.0	-0.4	2.0	2.5	3.9	2.6	1.0	0.4
Allergy	2.5	5.8	24.9	-3.7	-1.5	-0.8	-5.0	-0.2	0.1	0.5	-1.5	-1.8	-4.5	-2.1	-1.4	-1.1
Blood White Count	2.4	17.7	43.7	2.8	6.6	4.0	5.8	2.6	3.1	4.1	2.3	6.3	4.3	4.5	3.2	1.3
Overall health rating	2.4	5.1	15.4	-0.7	1.7	3.6	0.8	2.0	3.6	3.9	2.2	1.4	-0.4	0.9	2.3	2.2
Irritable Bowel Disease (IBD)	2.3	5.5	17.6	0.8	-0.9	-1.1	4.2	-4.1	-0.9	-0.6	-0.5	2.6	3.0	-0.3	3.5	2.2
Ovarian Cancer	2.3	3.0	10.8	1.8	0.6	0.6	2.1	0.3	1.2	1.2	1.6	3.3	2.4	1.4	2.3	1.3
Age at last live birth	2.3	3.4	7.3	-0.5	-1.9	-2.3	-1.4	-1.5	-2.6	-2.7	-1.7	-1.1	-0.5	-1.7	-2.5	-1.9
Fractured/broken bones in last 5 years	2.3	3.0	7.7	0.6	0.8	1.0	1.6	0.3	2.0	2.1	2.3	2.2	1.0	0.9	2.8	2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.6	6.7	1.1	1.2	1.3	2.2	0.5	1.3	0.8	1.9	2.6	1.3	0.9	1.8	2.4
Severe depression (siblings)	2.1	2.3	4.1	-1.5	-1.7	-1.5	-1.3	-1.5	-2.0	-2.0	-2.0	-1.0	-1.2	-1.2	-1.3	-1.0
Hayfever/allergic rhinitis (self-reported)	2.0	2.6	11.7	2.3	0.5	0.5	3.4	-0.0	-0.7	-1.3	0.7	1.7	2.7	1.2	0.8	1.0
Blood clot in the leg (DVT)	2.0	2.5	5.7	-1.5	-0.4	-1.2	-0.1	-1.2	-1.6	-1.5	-1.9	-2.1	-1.3	-2.4	-1.9	-1.9
Worry too long after embarrassment	2.0	3.4	7.0	-2.0	-1.4	-2.3	-2.2	-1.0	-1.1	-1.3	-1.0	-2.3	-2.6	-1.8	-1.5	-2.3
Deep venous thrombosis (DVT) (self-reported)	2.0	2.6	6.0	-1.7	-0.5	-1.4	-0.2	-1.2	-1.5	-1.4	-2.0	-2.1	-1.4	-2.4	-1.7	-1.9
Crohns Disease (2017)	1.9	4.2	13.3	0.6	-0.2	-0.3	3.6	-3.2	-0.1	0.2	-0.2	2.6	2.5	0.0	3.6	2.3
Nervous feelings	1.9	3.5	8.3	-2.9	-1.4	-2.4	-1.4	-2.7	-1.6	-1.3	-1.2	-1.7	-2.4	-2.0	0.1	-1.5
Noisy workplace	1.9	2.3	7.0	1.2	2.7	1.2	1.7	1.2	1.6	2.2	1.1	0.9	1.6	1.3	1.4	0.5
Birth weight of first child	1.9	3.4	8.3	-1.4	-2.6	-2.9	-1.3	-2.3	-1.8	-2.2	-1.6	-0.3	-1.2	-2.5	-1.2	-0.3
Age at first live birth	1.9	3.4	8.2	0.4	-1.6	-2.8	-0.9	-1.2	-2.6	-2.9	-1.8	-0.7	0.1	-1.1	-2.3	-2.4
Osteoarthritis (self-reported)	1.9	2.4	9.0	0.0	0.4	1.0	1.3	0.4	2.5	2.5	1.6	1.4	0.3	0.4	3.0	1.6
Bipolar Disorder (2011)	1.8	1.7	6.7	-1.3	-2.1	-2.6	-1.4	-2.1	-0.8	-1.0	0.0	-0.6	-1.1	0.0	0.4	-0.0
Crohns Disease (2012)	1.8	2.9	9.0	0.8	-0.3	0.8	3.0	-1.7	0.7	0.7	0.1	2.1	2.2	-0.2	2.6	2.8
Mouth/teeth dental problems	1.8	2.7	10.3	-1.3	2.0	0.7	-1.5	1.9	2.6	3.2	1.4	0.1	-1.7	0.2	1.0	-0.3
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	5.5	1.2	1.7	1.3	1.0	1.9	2.0	1.9	1.8	2.3	0.9	0.8	1.0	0.2
Schizophrenia vs Biploar Disorder	1.7	2.2	4.0	0.7	1.9	1.5	1.6	0.9	1.4	1.8	2.0	1.2	1.2	1.7	1.8	0.8
Worry (Nagel 2018)	1.7	3.5	7.9	-1.9	-1.2	-2.4	-1.9	-1.8	-1.6	-1.2	-1.9	-2.8	-1.9	-1.4	-1.0	-2.4
Lupus	1.7	2.6	8.2	-2.5	-2.0	-1.0	-2.3	-1.4	-0.4	-0.5	-1.1	-0.5	-2.9	-2.1	-0.2	0.9
Neuroticism (2016)	1.7	2.5	7.6	-1.2	-1.0	-1.6	0.6	-2.8	-2.1	-1.5	-2.4	-1.5	-0.1	-1.8	0.0	-1.2
Financial difficulties in last 2 years	1.7	2.3	10.6	-3.3	-1.2	0.3	-0.9	-0.8	0.9	1.0	0.3	-1.3	-2.8	-2.0	0.8	-0.3
Qualifications: A levels/AS levels or equivalent	1.7	3.8	8.7	-1.0	-2.2	-2.0	-0.6	-2.3	-2.9	-3.0	-2.0	-1.5	-0.8	-2.2	-1.7	-1.5
Mouth/teeth dental problems: Bleeding gums	1.7	2.1	5.4	-0.6	-2.0	-0.1	-0.5	-1.3	-2.0	-2.1	-2.0	-2.3	-0.4	-0.9	-1.6	-0.2
Medication for pain relief, constipation, heartburn	1.7	2.9	6.4	-0.5	-2.0	-1.4	-2.1	-0.9	-2.5	-2.5	-1.9	-1.3	-0.9	-1.1	-2.2	-1.0
Coronary Artery Disease (CAD)	1.6	1.9	4.0	-0.9	-2.0	-1.5	-2.0	-0.8	-1.4	-1.6	-1.2	-0.9	-1.2	-1.7	-1.6	-0.0
Triglycerides	1.6	2.6	7.1	1.1	1.5	1.3	2.7	0.5	1.4	1.6	1.6	1.3	1.8	1.4	2.2	1.5
Average weekly fortified wine intake	1.6	1.9	6.5	-1.6	-1.3	-2.5	-0.9	-1.9	-1.0	-1.4	-0.8	0.1	-1.9	-1.4	-0.0	-0.1
Stomach or abdominal pain in last month	1.6	2.0	7.7	0.7	0.5	1.9	2.8	-0.6	0.4	0.5	0.5	1.7	2.0	1.2	1.6	1.6
Mouth/teeth dental problems: Loose teeth	1.6	1.9	6.5	1.7	1.2	1.7	2.6	1.4	0.4	0.2	0.9	1.7	1.8	1.1	0.4	0.4
Suffer from ‘nerves’	1.6	2.5	8.1	-2.4	-0.4	-1.5	-1.6	-1.1	-0.6	-0.3	-1.6	-1.3	-2.2	-1.5	-0.5	-2.9
Miserableness	1.6	2.8	5.2	-2.2	-0.7	-1.2	-1.2	-1.3	-1.9	-1.3	-2.3	-2.0	-1.7	-1.7	-1.4	-1.8
Supplements: Fish oil (including cod liver oil)	1.6	2.0	5.5	1.4	0.3	-1.0	1.0	-0.0	1.2	1.0	2.0	2.0	1.7	1.0	2.4	1.5
Ever depressed for a whole week	1.6	2.0	7.7	-2.8	-1.4	-1.2	-1.7	-1.1	0.1	0.3	0.0	-0.4	-2.4	-1.8	0.7	0.7
Alcohol drinker status: Previous	1.6	1.9	4.0	-1.3	-0.0	-1.8	-1.1	-1.1	-1.4	-0.9	-1.9	-2.0	-1.3	-1.0	-0.9	-1.6
Ulcerative Colitis (UC)	1.5	2.9	10.9	0.7	-1.0	-1.5	3.0	-3.3	-1.3	-1.2	-0.8	0.8	2.2	-0.3	1.9	0.9
Fluid intelligence score	1.5	3.1	10.8	-0.1	-0.6	-1.6	-2.7	0.3	-1.8	-1.9	-1.7	-0.8	-1.1	-0.9	-3.3	-2.7
Exposure to tobacco smoke at home	1.5	1.7	4.5	-0.6	2.0	1.5	-0.2	1.8	1.9	2.1	1.5	0.5	-0.7	0.4	0.4	0.4
Medication: Paracetamol	1.5	2.5	8.6	-0.8	1.7	1.1	0.8	0.9	2.6	2.9	1.9	-0.0	-0.5	0.7	2.6	0.6
Birth weight	1.5	3.4	8.2	0.4	1.5	1.2	0.9	1.6	2.7	2.8	2.9	2.5	0.4	1.4	1.8	1.2
Health satisfaction	1.5	1.9	5.1	-2.0	-0.2	0.3	-0.3	-0.5	1.9	2.3	1.6	-0.2	-1.5	-0.8	2.2	1.1
Medication: Aspirin	1.5	2.0	4.1	1.3	0.8	1.9	1.6	1.3	1.4	1.2	1.6	2.0	1.4	1.3	0.6	1.4
Mineral and other dietary supplements	1.5	2.0	4.8	-1.7	-0.6	1.0	-0.3	-0.5	-1.2	-1.0	-1.9	-2.2	-1.7	-1.5	-2.1	-1.0
Hand grip strength (left)	1.4	3.6	6.1	1.8	2.4	1.9	2.5	1.7	1.9	2.0	1.6	1.5	2.3	2.0	1.3	1.6
Vitamin and mineral supplements	1.4	1.9	6.8	-1.0	-1.2	0.3	-1.2	-0.2	-1.1	-1.4	-1.9	-1.9	-1.4	-1.1	-2.6	-0.6
Tense / ‘highly strung’	1.4	2.4	7.1	-2.7	-0.3	-1.7	-2.0	-1.2	0.1	0.6	-1.2	-1.4	-2.5	-1.5	0.1	-1.7
Medication: Seretide 50 evohaler	1.4	1.6	5.7	0.8	1.6	2.4	0.7	2.0	1.0	1.4	1.2	0.1	1.0	1.4	0.2	0.1
Number of full sisters	1.4	1.6	5.1	-1.8	0.5	0.9	0.1	0.3	2.2	2.3	0.9	0.8	-1.4	-0.2	1.6	1.2
Long-standing illness, disability or infirmity	1.4	2.2	6.4	-0.5	1.5	2.4	1.3	1.1	2.3	2.5	1.4	1.1	0.0	0.1	1.5	0.3
Hearing difficulty/problems: Yes	1.3	1.9	4.9	1.0	2.2	2.2	0.6	1.8	1.3	1.7	0.2	0.7	0.9	2.0	0.3	0.9
Relative age voice broke	1.3	2.1	9.5	-1.5	-1.1	-3.1	-0.5	-2.2	-0.3	-0.1	-0.5	-0.4	-1.0	-1.8	1.3	-1.4
Taking other prescription medications	1.3	2.0	4.7	1.9	1.4	2.2	1.7	1.7	1.3	0.7	0.8	0.9	2.0	1.4	0.1	0.2
Wheeze or whistling in the chest in last year	1.3	2.3	4.9	1.8	1.2	1.5	2.2	1.0	0.8	0.9	1.2	2.2	2.2	1.9	0.9	0.6
Medication: Blood pressure	1.3	2.4	6.3	0.3	0.5	2.5	-0.1	1.8	2.4	2.3	1.5	0.4	0.0	1.1	1.4	2.0
Medication: Ibuprofen	1.3	1.5	3.4	0.8	1.4	1.1	0.7	1.6	1.7	1.8	1.6	1.5	0.6	0.6	0.9	0.1
Osteoporosis (self-reported)	1.3	1.6	3.3	0.9	1.3	0.1	-0.6	1.1	1.7	1.7	1.5	1.4	0.3	1.7	1.8	0.2
Average weekly beer plus cider intake	1.3	1.9	7.1	-2.7	-0.4	-0.3	-1.8	-0.1	0.0	0.6	-1.1	-0.8	-2.6	-2.0	-0.5	-0.9
Reaction Time	1.2	2.3	4.8	-0.4	-1.0	-1.4	-1.0	-0.9	-2.2	-2.0	-1.9	-1.3	-0.4	-1.7	-2.0	-1.9
Primary Biliary Cirrhosis	1.2	1.7	5.1	-2.0	0.8	-0.3	-1.5	0.1	-0.3	0.2	-0.8	-2.2	-2.1	-0.9	-1.2	-1.5
Blood Eosinophil Count	1.2	9.5	37.7	3.6	5.1	2.3	6.1	1.1	-1.0	-0.4	-0.4	1.8	5.0	3.1	-0.2	-1.2
Had other major operations	1.2	1.4	4.9	-0.7	0.1	0.5	0.9	-0.3	1.8	1.5	1.4	1.1	-0.3	0.4	2.2	1.7
High blood pressure (siblings)	1.2	1.7	5.7	-0.4	1.0	1.2	0.7	0.3	2.1	2.4	1.1	-0.0	-0.0	0.3	2.1	1.8
Comparative body size at age 10	1.2	3.4	8.6	1.9	2.9	2.0	1.3	2.0	1.6	2.1	1.0	1.4	2.1	2.6	0.5	-0.3
Shortness of breath walking on level ground	1.2	1.4	3.3	-1.5	-1.1	-0.3	-0.2	-0.5	1.5	1.5	1.6	1.2	-1.0	-1.0	1.8	1.0
Qualifications: nursing, teaching	1.2	1.8	5.3	-0.5	-0.5	-2.3	-0.0	-2.1	-1.9	-1.4	-2.2	-0.7	0.3	-1.2	-0.9	-0.6
Medication: Paracetamol	1.2	1.9	5.9	-0.1	1.1	1.1	0.6	1.0	2.2	2.4	2.0	0.2	0.1	1.1	2.1	0.7
Risk taking	1.2	1.8	5.2	-2.1	-1.2	-0.9	-1.4	-1.4	-1.1	-0.3	-1.6	-2.3	-1.4	-1.1	-0.2	-0.8
Schizophrenia (2018)	1.1	2.2	4.1	-1.2	-1.7	-1.1	-1.2	-1.5	-1.9	-1.6	-1.9	-2.0	-0.6	-1.4	-0.7	-1.6
Verbal and Numeric Reasoning (VNR)	1.1	2.7	6.8	0.2	-0.2	-2.1	-1.6	-0.5	-2.0	-1.8	-2.1	-1.4	-0.2	-0.6	-2.6	-2.5
Neuroticism	1.1	2.6	7.4	-2.3	-0.7	-2.1	-0.9	-2.4	-1.3	-0.7	-1.6	-2.7	-1.6	-1.2	0.7	-1.0
Sensitivity / hurt feelings	1.1	1.8	7.4	-1.1	-0.6	-0.8	-1.7	-0.4	-0.9	-0.7	-1.4	-2.7	-1.2	-0.4	-1.4	-2.0
Heart attack	1.1	1.4	8.6	0.9	1.2	2.9	1.4	1.3	0.7	0.6	0.4	0.6	1.1	1.0	-0.2	0.0
Worrier / anxious feelings	1.1	2.1	5.2	-0.9	-0.1	-1.9	-1.9	-0.7	-1.2	-0.9	-1.4	-2.3	-1.1	-1.1	-1.3	-2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	5.7	-1.2	-1.0	-1.0	-1.1	-0.5	-1.2	-1.2	-1.2	-1.3	-1.1	-1.1	-1.5	-2.4
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	5.2	-0.0	0.7	1.3	-0.9	2.1	2.3	1.9	1.9	2.2	-0.8	1.2	0.6	0.4
Knee pain experienced in last month	1.1	1.7	5.5	1.0	-1.3	1.2	0.5	0.9	1.9	1.0	2.3	1.4	0.6	0.6	1.3	1.5
Wears glasses or contact lenses	1.1	1.3	4.5	-1.1	-2.1	-1.4	-1.5	-1.3	-0.4	-0.9	-0.4	-0.4	-1.5	-1.3	0.3	0.7
Medication: Lisinopril	1.1	1.4	5.0	-0.4	-1.0	-1.2	0.5	-1.8	-1.3	-1.5	-2.2	-1.1	0.1	-1.2	-0.5	-0.4
Unable to work because of sickness or disability	1.1	1.4	6.2	-2.5	-0.5	0.3	-0.7	-0.3	0.7	0.8	-0.1	-1.6	-2.4	-1.1	0.2	-0.6
Neuroticism (Nagel 2018)	1.0	2.3	7.6	-1.3	-0.6	-1.7	-0.8	-1.5	-1.8	-1.2	-2.0	-2.8	-1.0	-1.1	-0.7	-1.8
Hand grip strength (right)	1.0	2.8	5.2	0.8	2.2	1.4	2.2	1.2	2.1	2.3	1.3	1.3	1.6	1.6	1.7	1.1
Fed-up feelings	1.0	1.9	6.2	-2.2	-1.5	-0.7	-1.5	-1.1	-0.5	-0.4	-0.9	-2.5	-1.9	-1.4	-0.2	-0.8
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.8	-0.4	-0.6	-0.8	-1.7	0.0	-1.0	-0.7	-1.4	-0.4	-0.7	-0.6	-1.7	-1.6
Hair/balding pattern: Pattern 2	1.0	1.2	3.0	0.7	1.3	1.7	0.2	1.4	1.6	1.5	1.1	0.5	0.2	1.1	0.8	0.8
Pain all over the body in last month	1.0	1.0	4.4	-1.6	1.2	0.2	-0.1	-0.1	1.4	2.1	-0.2	0.1	-1.0	0.1	1.2	-0.8
Father’s age at death	1.0	1.3	4.0	0.3	-0.8	-1.2	-0.2	-0.9	-1.9	-2.0	-0.7	0.1	0.0	-0.6	-1.5	-1.7
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	4.3	-1.1	-0.6	-1.7	-0.3	-1.6	-0.9	-0.7	-1.4	-0.5	-0.5	-2.1	-0.5	-0.7
Exposure to tobacco smoke outside home	1.0	1.3	4.1	-0.5	0.1	1.5	-1.9	2.0	0.7	0.5	-0.1	0.1	-1.3	0.5	-1.5	-1.1
Guilty feelings	1.0	1.5	6.4	-0.3	0.5	-1.8	0.3	-1.4	-1.6	-1.0	-1.2	-1.3	0.1	-0.9	-0.1	-2.5
Major Depression (MDD)	0.9	1.1	3.8	-1.1	0.6	0.3	0.1	-0.6	-1.2	-0.5	-1.5	-1.2	-0.7	-0.9	-1.3	-1.9
Rheumatoid Arthritis	0.9	1.3	7.3	1.1	0.7	0.5	2.7	-0.9	-0.6	-0.5	-0.1	-0.2	1.9	0.7	1.1	0.6
Schizophrenia (2014)	0.9	2.0	4.6	-1.5	-1.6	-1.5	-2.1	-1.0	-1.4	-1.1	-1.4	-1.6	-1.3	-1.4	-0.7	-1.2
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.8	0.1	1.1	1.2	1.4	0.1	1.0	1.5	0.8	1.0	0.7	0.5	1.7	0.5
Medication: Co-codamol	0.9	1.1	3.3	-1.2	0.8	0.2	1.6	-0.9	1.0	1.4	0.2	-0.1	-0.2	-0.4	1.8	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	5.9	-1.6	1.1	-0.5	1.0	-1.0	0.6	1.5	-0.4	-0.3	-0.5	-1.3	1.2	-2.4
Neuroticism score	0.9	2.0	5.7	-1.8	-0.3	-1.3	-1.6	-1.0	-1.1	-0.5	-1.4	-2.4	-1.6	-0.9	-0.5	-2.1
Hip circumference	0.9	3.9	12.0	-1.3	1.8	1.8	-0.1	1.6	3.3	3.5	1.9	1.3	-1.2	1.2	2.6	1.6
Pulse rate	0.9	1.6	6.4	-2.5	-0.3	-1.2	-0.6	-1.4	-0.5	-0.1	-0.3	-0.0	-1.8	-2.3	-0.1	-1.0
Mean time to correctly identify matches	0.9	1.8	5.0	0.3	-1.4	-1.2	-0.9	-0.8	-2.1	-2.2	-1.7	-0.8	0.2	-1.0	-2.0	-0.4
Family relationship satisfaction	0.9	1.1	3.7	-1.0	1.0	0.2	-1.9	1.0	0.5	0.9	-0.5	0.6	-1.3	-0.2	-1.0	-1.9
Friendships satisfaction	0.9	1.1	4.3	-0.8	-0.9	0.9	-2.1	1.1	0.8	1.0	0.4	0.1	-1.2	-0.6	-0.8	-1.3
Average weekly champagne plus white wine intake	0.9	1.2	5.6	0.2	-0.2	-2.4	-0.8	-1.4	-1.5	-1.2	-1.5	-1.3	0.1	0.1	-0.1	-0.1
Commuting to job workplace: Public transport	0.9	1.1	2.4	-1.4	-0.3	-1.4	-0.2	-1.2	-1.3	-1.0	-1.0	0.0	-1.0	-1.5	-0.5	-1.3
HDL Cholesterol	0.8	1.4	3.8	-0.3	-1.3	-0.3	-1.4	-0.2	-1.5	-1.6	-1.2	-1.2	-0.8	-1.2	-2.0	-0.8
Ulcerative Colitis	0.8	1.2	5.0	0.1	-0.0	-1.0	2.0	-2.2	-0.9	-0.7	-0.6	1.0	1.3	-0.2	1.2	0.5
Blood Red Count	0.8	7.6	19.4	2.3	4.1	3.4	4.4	1.7	2.0	2.3	1.6	1.0	3.5	3.5	1.6	1.7
Systolic Blood Pressure	0.8	3.8	10.7	-0.0	1.2	2.9	-1.1	3.3	2.8	2.9	2.0	1.6	-1.0	1.7	0.3	0.8
Chronotype (morning person)	0.8	2.0	7.3	2.7	0.1	-1.4	1.8	-0.2	0.3	-0.5	0.5	0.9	2.6	1.6	1.3	0.4
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.6	0.1	0.4	1.3	0.5	1.0	1.6	1.6	1.5	1.1	0.0	0.8	1.1	0.3
Alcohol usually taken with meals	0.8	1.2	4.1	0.8	-1.5	-2.0	0.4	-1.4	-1.1	-1.9	-0.7	-0.2	0.9	-0.4	-0.7	0.2
Prospective memory result	0.8	1.0	3.2	0.7	1.4	0.6	1.3	-0.0	0.9	1.0	0.4	0.3	1.2	1.5	1.8	0.5
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	5.5	-1.9	-0.9	-0.5	-2.0	-0.1	0.0	-0.0	-0.6	-0.6	-2.3	-0.8	-0.6	-1.0
Number of full brothers	0.8	1.0	2.1	-1.5	-0.1	-0.8	-0.4	-0.9	-1.1	-0.8	-1.2	-0.9	-1.2	-1.3	-0.9	-1.4
Neck or shoulder pain in last month	0.8	1.2	2.6	1.4	0.2	0.8	1.0	0.5	0.9	0.7	0.8	0.8	1.6	1.6	1.4	1.2
Number of operations (self-reported)	0.8	1.1	3.2	0.1	0.8	0.9	0.6	0.9	1.8	1.2	1.6	0.9	-0.2	1.4	1.3	0.5
Cholesterol lowering medication	0.8	1.2	4.0	0.5	0.7	0.4	1.6	-0.4	0.7	1.1	0.5	0.3	1.5	1.0	1.9	2.0
Mean Putamen Volume	0.7	0.8	2.4	0.5	1.2	-0.6	1.0	-0.7	0.4	0.6	0.1	1.6	1.1	0.6	1.0	1.1
Fasting Glucose	0.7	0.9	3.2	1.5	-0.5	0.4	0.2	1.2	0.7	0.3	1.1	-0.9	1.0	1.8	0.0	-0.1
HbA1C	0.7	0.8	2.7	0.9	-0.1	-1.0	1.0	-0.7	-0.2	-0.1	0.1	1.6	1.4	0.8	0.9	0.9
Hypothyroidism (self reported)	0.7	1.7	5.5	0.4	0.5	1.0	-0.6	1.8	2.0	1.3	1.9	2.4	-0.5	1.3	0.5	0.2
Systolic blood pressure, automated reading	0.7	1.9	5.1	-0.6	1.4	1.9	-0.6	1.8	2.0	2.3	0.5	0.8	-1.1	1.1	0.7	1.5
Supplements: Zinc	0.7	0.8	5.4	-0.7	-0.3	-0.7	-0.2	-0.5	0.9	1.1	0.8	0.2	-0.5	-0.2	2.3	0.8
Trunk fat percentage	0.7	2.8	7.7	-2.6	2.1	1.0	-0.8	0.7	2.2	2.8	0.6	1.4	-2.1	-0.3	1.5	1.3
Townsend deprivation index at recruitment	0.7	1.0	4.5	-2.1	0.1	1.2	-0.5	0.4	0.7	0.9	1.0	0.2	-1.9	-0.5	0.2	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	3.6	-1.0	1.0	1.0	1.0	0.1	1.5	1.9	0.7	0.1	-0.2	0.1	1.4	-0.4
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.5	-0.6	0.5	-0.4	1.4	-1.6	-1.2	-0.7	-1.5	0.4	0.5	0.1	0.6	0.4
Trunk fat mass	0.7	3.2	9.8	-2.4	1.7	1.2	-0.8	0.9	2.7	3.1	1.0	1.3	-2.0	-0.0	1.8	1.7
Number of incorrect matches in round	0.7	1.1	3.8	0.8	0.6	0.1	0.2	0.7	1.4	1.5	1.1	0.2	1.1	0.7	1.5	1.9
Illnesses of siblings	0.7	1.0	4.2	0.4	-1.1	-0.6	-0.9	0.3	-1.4	-2.1	-0.4	0.6	-0.2	0.1	-1.6	-1.2
Illnesses of mother	0.7	0.9	2.2	0.4	1.3	0.8	-0.3	1.3	0.6	0.5	1.3	1.4	0.1	1.5	-0.1	-1.2
Body fat percentage	0.7	2.7	7.8	-2.4	1.9	0.9	-0.7	0.5	2.2	2.8	0.6	1.6	-1.8	-0.2	1.7	1.7
Medication: Omeprazole	0.7	0.8	3.8	0.0	-1.1	-0.6	0.6	-1.3	0.5	0.4	0.1	0.4	0.7	-0.1	1.3	2.0
Whole body fat mass	0.7	2.7	8.4	-2.3	1.3	0.8	-0.9	0.6	2.5	2.9	0.9	1.1	-1.9	-0.1	1.9	1.7
Breast cancer (self-reported)	0.7	0.9	3.2	1.2	-1.1	-0.5	-1.0	0.4	-1.2	-1.4	-0.1	0.1	0.7	-0.2	-1.8	-0.1
Medication: Aspirin	0.7	0.9	2.5	1.2	0.2	0.9	1.3	0.6	0.7	0.4	1.1	1.6	1.3	0.8	0.2	1.0
Medication: Gliclazide	0.7	0.8	2.2	-1.1	0.9	0.6	-1.5	0.4	0.1	0.7	-0.7	-1.4	-1.2	-0.4	-0.5	-0.7
Financial situation satisfaction	0.7	0.8	3.7	-1.9	0.3	1.1	-0.5	0.1	0.9	1.2	0.3	-0.4	-1.5	-0.3	0.4	-0.4
Irritability	0.7	1.2	3.6	0.4	0.3	0.8	0.3	0.9	1.9	1.7	1.7	0.7	0.5	1.1	1.4	0.7
Age started oral contraceptive pill	0.7	0.9	2.3	-0.5	-1.1	-1.0	-0.6	-1.0	-1.1	-1.2	-0.9	-1.5	-0.7	-0.7	-0.8	-0.2
Blood Platelet Count	0.6	7.1	26.8	-2.3	-5.2	-3.2	-3.6	-2.4	0.5	-0.3	1.3	2.7	-2.7	-1.5	1.9	3.0
BMI	0.6	3.5	10.9	-0.2	3.2	2.5	0.2	2.5	2.6	3.3	0.8	1.1	-0.0	1.5	0.8	0.5
Frequency of depressed mood in last 2 weeks	0.6	0.9	3.0	-0.8	1.3	0.6	1.7	-0.8	0.4	1.1	-0.6	-0.3	0.3	-0.3	1.4	-1.0
Medication for hormone replacement therapy	0.6	0.6	1.8	-0.0	-0.4	-0.5	1.4	-1.3	-0.6	-0.5	-0.1	0.1	0.7	-0.6	0.9	1.3
Diabetes (mother)	0.6	0.8	3.8	-0.3	-1.9	-0.9	-0.8	-0.8	-0.6	-1.0	-0.6	0.2	-0.6	-1.0	-0.6	0.7
Chronic bronchitis/emphysema (father)	0.6	0.7	2.2	0.2	-0.1	-0.3	0.3	-0.1	-1.5	-1.4	-1.4	-0.4	0.4	-0.5	-1.4	-0.5
Had menopause	0.6	0.8	3.2	-0.5	-0.8	-0.6	0.4	-1.4	-0.8	-0.8	-0.6	-1.8	-0.1	-0.7	0.3	1.1
Qualifications: None of the above	0.6	1.2	3.2	0.5	0.5	1.8	-0.3	1.7	1.6	1.3	1.1	0.7	-0.0	0.9	-0.1	1.4
Diabetes (self-reported)	0.6	0.9	3.3	-0.4	0.8	1.3	1.2	-0.1	0.8	1.5	0.4	0.4	0.5	0.3	1.8	0.6
Medication: Simvastatin	0.6	0.9	3.2	-0.1	1.0	-0.2	1.8	-1.3	-0.1	0.8	-0.3	-0.3	1.2	-0.0	1.6	0.5
Arm fat percentage (right)	0.6	2.2	7.3	-1.8	2.1	1.1	-0.4	0.8	1.9	2.7	0.5	1.3	-1.2	0.1	1.8	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	3.3	-0.3	1.2	1.3	0.7	0.9	1.4	1.8	0.1	0.2	0.3	-0.1	0.7	-1.2
Hair/balding pattern: Pattern 3	0.6	0.9	2.2	1.1	-0.1	0.0	1.4	-0.9	-1.4	-1.2	-1.1	-0.1	1.5	0.2	-0.2	-0.8
Arm fat mass (right)	0.6	2.3	8.1	-1.7	1.6	1.2	-0.5	1.1	2.3	2.8	0.8	1.1	-1.4	0.2	1.5	1.4
Medication: Amlodipine	0.6	0.9	2.7	-0.8	0.1	0.9	-0.8	0.5	1.4	1.7	0.8	0.5	-0.8	0.7	1.2	1.0
Qualifications: College or University degree	0.6	1.8	5.0	0.3	-1.7	-1.6	0.4	-1.6	-2.2	-2.2	-1.0	0.7	0.8	-1.1	-1.0	-0.6
Eye problems/disorders: None of the above	0.6	0.7	2.0	-0.8	0.0	-0.4	-1.1	-0.1	-1.0	-0.7	-0.8	-1.1	-0.8	-0.5	-1.4	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.0	0.8	0.7	0.5	1.4	0.2	1.0	0.8	0.5	0.6	0.8	1.1	1.2	0.3
Leg fat mass (right)	0.6	2.1	6.6	-1.9	0.8	0.7	-0.5	0.4	2.2	2.6	0.8	1.1	-1.4	-0.1	1.7	2.0
Leg pain on walking	0.6	0.7	1.9	-1.0	-1.0	-0.8	-0.6	-1.3	-0.6	-0.5	-0.2	-0.9	-0.8	-1.4	-0.4	-0.4
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.6	1.1	0.7	-0.1	1.2	-0.3	0.5	0.7	0.9	0.2	1.6	0.8	1.0	0.8
Arm fat percentage (left)	0.6	2.3	7.3	-1.9	2.2	1.0	-0.2	0.7	2.1	2.7	0.6	1.4	-1.3	0.2	1.9	1.1
Loneliness, isolation	0.6	0.9	3.9	-0.2	0.3	2.0	0.5	0.9	1.4	1.6	0.8	-0.3	-0.1	0.6	0.6	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.7	0.7	0.1	1.3	1.1	0.0	0.5	0.6	0.4	0.4	1.0	0.8	1.1	1.3
Arm fat mass (left)	0.6	2.5	8.8	-1.7	1.8	1.2	-0.4	1.0	2.4	3.0	0.8	1.2	-1.4	0.2	1.8	1.3
Hearing aid user	0.6	0.7	1.4	-0.6	-0.9	-1.0	-0.6	-1.1	-1.0	-1.2	-0.8	-0.3	-1.0	-0.4	-0.4	0.1
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.4	-0.5	-1.1	-1.6	0.6	-1.6	-0.7	-1.2	-0.3	-0.6	-0.3	-0.8	0.7	0.5
Commuting to job workplace: Cycle	0.6	0.7	3.0	0.1	-0.4	-0.0	-1.2	1.7	0.7	0.2	0.5	0.3	-1.1	0.1	-1.2	-1.1
Myopia	0.6	0.9	2.4	-0.9	0.3	0.4	-1.3	1.3	0.3	0.4	0.5	-0.4	-1.3	-0.4	-1.3	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.8	-0.2	-0.5	-0.1	0.9	-0.8	1.0	0.9	0.5	0.5	0.4	-0.0	1.7	1.5
Basal cell carcinoma (self-reported)	0.6	0.8	3.2	0.1	1.8	1.7	0.7	1.0	0.3	0.4	0.4	-0.2	0.1	1.1	-0.4	-0.7
Heart attack/myocardial infarction (self-reported)	0.6	0.8	6.9	0.4	0.7	2.6	0.8	1.0	0.5	0.3	-0.0	0.2	0.6	0.6	-0.5	-0.1
Age at First Birth	0.5	0.8	2.0	-0.4	-1.4	-1.4	-0.7	-1.0	-0.5	-0.9	-0.4	0.1	-0.7	-1.3	0.0	-0.8
Type 2 Diabetes (T2D) (2018)	0.5	0.8	3.6	-1.3	-0.6	0.4	0.1	-0.9	0.8	1.1	0.4	0.7	-0.5	-0.5	1.9	1.1
Number of treatments/medications taken	0.5	0.8	1.3	1.0	0.6	0.6	0.8	0.9	1.1	0.9	1.1	0.8	1.1	1.0	0.8	1.0
Average weekly spirits intake	0.5	0.6	1.3	-1.0	-0.7	-0.9	-0.3	-0.7	-0.9	-1.1	-0.5	-0.7	-1.0	-0.5	-0.8	-0.0
Relative age of first facial hair	0.5	0.9	5.1	-1.0	-0.9	-2.3	-0.5	-1.3	-0.3	0.0	-0.0	0.2	-0.5	-1.1	1.0	-0.9
Medication: Metformin	0.5	0.7	2.5	-1.5	-0.5	0.0	0.8	-1.6	-0.2	0.4	-0.5	-0.1	-0.3	-1.5	1.0	0.2
Pack years adult smoking proportion	0.5	0.8	2.1	-1.0	-1.1	-1.4	-0.9	-1.0	0.6	0.2	-0.3	-1.1	-1.2	-0.2	0.7	0.6
Serious illness, injury or assault to yourself	0.5	0.6	2.0	0.7	0.7	0.7	1.4	0.4	0.6	0.5	-0.0	-0.4	1.1	0.4	0.6	-1.0
High blood pressure	0.5	1.3	3.0	-1.6	-1.0	0.7	-1.7	0.6	1.3	1.5	0.3	-0.3	-1.7	-0.7	0.6	1.2
Multivitamins +/- minerals	0.5	0.6	2.4	-0.2	1.0	-1.1	0.6	-0.5	-0.1	0.5	0.6	1.3	0.6	-0.2	1.5	-0.5
Waist circumference	0.5	1.7	6.5	-2.5	-0.4	0.5	-1.8	0.1	1.0	1.4	-0.7	-0.7	-2.3	-0.7	0.2	1.4
Medication: Ramipril	0.5	0.7	3.1	0.6	1.8	0.5	-0.5	1.2	0.4	0.8	-0.4	0.9	0.6	1.2	-0.3	-0.0
Weight	0.5	2.5	8.5	-1.6	0.9	1.3	-0.7	1.1	2.7	2.9	1.3	0.6	-1.5	0.4	1.8	1.7
Alcohol intake versus 10 years previously	0.5	0.7	3.9	-1.2	0.6	2.0	0.3	0.3	0.7	1.0	0.5	-0.0	-0.5	0.0	0.6	0.8
Depression (self-reported)	0.5	0.6	2.3	-0.7	0.2	-0.7	0.2	-0.9	-0.7	-0.4	-1.5	-0.8	0.1	-1.1	-0.1	-1.1
Pulse wave Arterial Stiffness index	0.5	0.6	2.0	-1.4	-0.6	-0.6	-0.0	-1.2	-0.0	-0.1	-0.9	-0.5	-0.9	-1.1	0.6	0.3
Gout (self-reported)	0.5	0.7	2.1	0.2	0.1	0.7	1.5	-0.5	0.2	0.2	1.4	1.3	0.5	-0.6	0.9	1.0
Leg fat percentage (right)	0.5	1.8	5.1	-1.6	1.1	0.7	-0.5	0.4	1.9	2.3	0.5	1.6	-0.9	0.0	1.4	2.1
Pulse wave peak to peak time	0.5	0.5	1.6	1.3	0.5	0.7	-0.2	1.2	0.0	0.1	0.8	0.4	0.7	1.0	-0.7	-0.4
Illnesses of siblings: Diabetes	0.5	0.6	2.3	-0.8	1.0	0.8	0.5	-0.1	0.9	1.5	-0.1	-1.1	-0.2	-0.2	0.6	-0.2
Illnesses of father: None of the above (group 1)	0.5	0.7	2.9	-0.1	0.6	-0.3	-0.9	0.3	-0.6	-0.7	-0.6	-1.1	-0.7	-0.1	-1.2	-1.7
Mother’s age at death	0.5	0.7	3.6	-0.4	-0.4	-1.9	-0.1	-1.6	-0.2	-0.2	0.0	0.2	0.0	-0.3	1.3	-0.5
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.5	1.2	0.9	0.3	0.0	0.9	-0.6	-0.4	-0.8	-1.0	0.9	0.8	-0.8	-0.4
Diastolic blood pressure, automated reading	0.5	1.4	3.6	-1.3	0.6	1.0	-1.9	1.3	1.6	1.6	0.6	0.4	-1.8	0.4	-0.2	1.1
Leg fat mass (left)	0.5	1.9	5.8	-1.8	0.9	0.6	-0.6	0.4	2.1	2.4	0.6	1.0	-1.3	-0.1	1.6	1.8
Depression (Nagel 2018)	0.4	0.6	2.2	0.0	1.5	0.9	0.7	0.5	0.7	1.3	-0.3	-0.4	0.4	0.6	0.4	-1.2
Body Mass Index (BMI) (2010)	0.4	0.6	1.4	0.4	1.2	0.6	0.4	0.8	1.0	1.1	0.3	0.6	0.5	1.2	0.3	-0.3
LDL Cholesterol	0.4	0.7	2.0	0.5	-0.4	0.7	1.3	-0.5	0.0	0.1	0.3	-1.4	1.0	-0.4	0.8	1.4
Type 2 Diabetes (T2D) (2012)	0.4	0.5	2.2	0.2	-0.5	-0.4	0.5	-0.5	0.4	0.2	0.7	-0.1	0.3	0.6	1.5	1.4
Heel T-Score	0.4	2.9	8.3	-1.9	-2.4	-1.2	-0.2	-2.9	-1.9	-1.7	-1.9	-1.2	-1.1	-2.1	-0.4	1.1
Smoking Status	0.4	0.9	3.4	-0.7	0.3	-0.4	-0.0	-0.4	-1.6	-1.0	-1.6	0.0	-0.6	-0.4	-1.1	-1.8
Lung FVC	0.4	2.2	8.3	0.1	-0.5	0.3	-0.4	-0.1	-2.1	-1.3	-2.2	-2.9	0.5	-1.0	-2.4	-1.6
Ever used hormone-replacement therapy (HRT)	0.4	0.5	2.2	-0.5	1.0	0.0	0.1	-0.2	1.1	1.2	0.3	0.0	-0.2	0.2	1.5	0.9
Diabetes (father)	0.4	0.5	1.4	-1.2	-0.1	-0.4	-0.5	-0.8	-0.6	-0.6	-0.8	-0.4	-1.0	-0.7	-0.2	-1.1
Current tobacco smoking	0.4	0.7	1.8	-0.8	-0.7	-1.0	0.4	-1.3	-1.1	-0.9	-0.8	-0.8	-0.4	-0.5	-0.5	-1.4
Qualifications: CSEs or equivalent	0.4	0.5	2.2	-0.5	-0.5	0.4	-0.2	0.1	1.0	0.7	1.2	0.8	-0.6	0.3	1.5	0.5
Supplements: Glucosamine	0.4	0.5	2.0	1.3	0.3	-1.4	0.3	0.1	0.3	-0.0	0.2	0.5	0.9	0.7	1.0	0.4
Body mass index (BMI)	0.4	1.8	6.4	-1.2	1.3	1.3	-0.3	1.1	2.1	2.5	0.6	1.0	-0.9	0.5	1.4	1.6
Impedance of leg (left)	0.4	1.8	4.0	-0.7	-0.7	-1.5	-0.4	-1.6	-2.0	-2.0	-1.7	-0.6	0.1	-1.5	-1.6	-1.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.9	-0.8	-0.5	-1.4	-0.5	-1.2	-0.1	0.3	-0.5	0.1	-0.2	-0.4	1.2	0.1
Number of live births	0.4	0.5	2.8	-0.2	-0.4	-0.2	-0.1	-0.5	-0.9	-0.5	-0.1	-1.7	-0.2	-0.8	-0.1	1.2
Medication: Cholesterol lowering	0.4	0.6	3.5	1.0	0.5	0.5	1.3	-0.3	-0.3	0.3	-0.7	-0.6	1.9	0.3	0.4	0.7
Peak expiratory flow (PEF)	0.4	1.0	3.6	1.9	1.0	0.4	1.2	0.7	-0.1	-0.2	0.8	-0.7	1.8	1.3	0.0	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.4	-0.6	1.2	0.9	-0.2	0.5	0.5	0.8	-0.3	-0.6	-0.8	0.8	0.6	-0.6
Had major operations	0.4	0.5	1.4	-1.1	0.2	-0.2	0.0	-0.1	1.0	0.9	1.2	0.5	-0.9	-0.0	0.9	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.3	0.8	0.1	0.4	-0.1	0.9	1.1	0.7	1.0	-0.4	0.1	0.7	0.7	0.6
Hypertension (Self-reported)	0.4	1.2	3.0	-1.6	-0.8	0.5	-1.7	0.5	1.1	1.3	-0.1	-0.8	-1.7	-0.7	0.3	1.2
Illnesses of father: Heart disease	0.4	0.5	1.8	0.2	-1.1	-0.4	0.7	-0.9	0.4	0.3	0.5	-0.2	0.6	-0.0	1.3	1.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	3.0	-0.5	-1.1	-0.3	-0.8	0.2	0.3	0.2	0.8	-0.2	-0.9	-1.7	-0.1	-0.1
Ever taken oral contraceptive pill	0.4	0.5	1.8	-0.4	0.9	-0.4	0.5	-0.4	-0.8	-0.4	-1.2	-0.2	0.3	-0.6	-0.1	-1.3
Medication: Bendroflumethiazide	0.4	0.6	1.9	-0.2	0.6	0.4	0.3	0.0	0.9	1.3	0.6	1.2	0.2	0.2	1.2	1.4
Illnesses of father: High blood pressure	0.4	0.5	1.6	-1.1	0.3	1.1	-0.3	0.4	0.9	1.2	0.5	-0.2	-0.8	-0.5	0.2	-0.2
Leg fat percentage (left)	0.4	1.5	4.0	-1.8	0.9	0.5	-0.8	0.2	1.6	2.0	0.2	1.4	-1.2	-0.3	1.2	1.7
Pack years of smoking	0.4	0.6	1.4	-0.7	-0.8	-1.2	-0.8	-0.8	0.8	0.4	-0.2	-1.0	-0.9	0.3	0.9	1.0
Depressed Affect (Nagel 2018)	0.3	0.6	3.3	-0.8	-0.6	-0.4	-0.2	-0.8	-0.6	-0.2	-1.2	-1.8	-0.4	-0.6	0.1	-0.4
Intelligence (Savage-Jansen 2018)	0.3	0.9	4.3	0.5	0.9	-0.2	-1.0	0.7	-0.7	-0.7	-1.1	-0.3	-0.1	0.3	-1.6	-2.1
Breast Cancer	0.3	0.6	1.6	-0.5	0.9	0.4	-1.2	1.1	0.6	0.5	0.0	0.1	-1.0	-0.1	-0.8	-1.3
Lung FEV1/FVC ratio	0.3	1.5	4.6	0.1	0.7	-1.4	0.9	-1.7	-2.1	-1.2	-1.8	-0.2	1.0	-0.2	0.3	-1.8
Angina	0.3	0.4	1.9	-0.6	-1.0	0.3	-0.5	-0.1	0.1	-0.2	0.1	1.0	-0.7	0.0	-0.0	1.4
Leg fat-free mass (left)	0.3	1.7	4.5	-1.6	0.1	0.8	-0.6	0.7	2.1	2.1	1.3	-0.3	-1.9	0.0	1.5	1.0
Maternal smoking around birth	0.3	0.5	1.3	-0.7	-0.9	-0.5	-0.4	-0.9	-0.2	-0.3	-1.0	-0.1	-0.5	-0.9	-0.0	1.1
High blood pressure (mother)	0.3	0.4	1.3	0.9	0.6	0.5	-0.4	1.1	0.6	0.8	0.4	-0.5	0.3	0.9	-0.3	0.5
Leg predicted mass (left)	0.3	1.8	4.9	-1.6	0.1	1.0	-0.6	0.8	2.2	2.1	1.4	-0.2	-1.9	0.1	1.5	1.1
Impedance of arm (right)	0.3	1.3	4.4	-2.1	0.2	-0.9	-0.7	-1.5	-1.0	-0.6	-0.5	-0.0	-1.4	-1.9	-0.1	-1.3
Time employed in main current job	0.3	0.4	1.1	-1.0	0.9	-0.6	0.5	-0.8	-0.0	0.5	-0.3	-0.7	-0.4	-0.6	0.4	-0.3
Falls in the last year	0.3	0.4	1.6	-0.8	-0.7	-0.3	0.4	-1.1	-0.8	-0.3	-0.3	0.3	0.0	-1.3	0.2	-0.6
Happiness	0.3	0.3	1.1	-1.0	0.0	0.2	-0.8	-0.1	-0.0	0.6	-0.4	0.0	-0.8	-0.7	-0.3	-0.9
Medication: Lansoprazole	0.3	0.3	1.0	-0.2	-0.0	-0.1	-0.7	0.3	-0.7	-0.6	-0.3	-0.8	-0.3	-0.2	-1.0	-0.6
Loud music exposure frequency	0.3	0.3	1.2	-0.8	-0.0	0.4	-0.6	0.3	-0.5	-0.3	-0.3	-0.2	-1.1	-0.2	-0.9	-0.8
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.9	-0.1	-0.4	-1.4	-0.7	-0.5	-0.7	-1.2	0.3	0.7	-0.6	-0.1	-0.4	-0.4
Glaucoma (self-reported)	0.3	0.4	1.7	-0.8	0.0	-1.3	0.6	-0.9	-0.2	-0.1	-0.6	-0.0	-0.5	-0.8	0.2	-0.3
Emphysema/chronic bronchitis	0.3	0.4	1.5	-0.5	-0.1	-0.4	0.9	-1.2	-0.1	-0.1	-1.0	-0.5	-0.2	-0.9	0.2	0.2
Angina (self-reported)	0.3	0.4	2.0	-0.6	-1.0	0.4	-0.6	0.0	0.3	0.0	0.2	1.0	-0.7	-0.1	-0.1	1.4
Migraine (self-reported)	0.3	0.3	1.0	-0.2	-0.3	1.0	-0.3	0.7	0.8	0.9	0.7	0.1	-0.6	0.2	-0.1	0.8
Heart disease (mother)	0.3	0.4	1.3	0.9	-0.1	0.7	1.1	0.1	0.4	0.1	-0.3	-0.2	0.9	0.0	0.2	1.1
Chest pain or discomfort	0.3	0.5	1.7	-1.3	-0.5	0.1	-0.2	-0.6	0.8	0.5	0.4	-0.1	-1.3	-0.9	0.5	0.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.8	0.9	-0.1	-0.1	-0.8	0.7	-0.2	-0.5	0.5	0.8	0.0	0.7	-0.8	-0.0
Leg fat-free mass (right)	0.3	1.4	3.8	-1.4	-0.0	0.7	-0.7	0.7	1.9	1.9	1.3	-0.5	-1.8	0.0	1.5	0.7
Diabetes diagnosed by doctor	0.3	0.4	1.7	-1.1	0.0	0.6	0.4	-0.8	0.4	1.0	0.0	0.2	-0.2	-0.4	1.3	0.4
Eye problems/disorders: Cataract	0.3	0.4	1.7	0.7	-0.3	0.1	1.3	-0.5	0.3	0.1	0.1	0.7	0.9	-0.2	0.9	0.6
Medication for cholesterol	0.3	0.4	1.5	-0.5	-0.2	-0.1	-0.9	0.5	0.2	-0.3	0.7	-0.6	-1.2	0.0	-0.4	-1.2
Back pain experienced in last month	0.3	0.5	2.0	-0.7	-0.6	-0.4	0.9	-0.9	0.1	-0.1	-0.3	-1.1	-0.3	-1.4	0.5	0.4
Smoking status: Current	0.3	0.5	1.9	-0.6	-0.2	-0.7	0.5	-1.0	-0.9	-0.6	-0.6	-0.4	-0.2	-0.2	-0.3	-1.4
Leg predicted mass (right)	0.3	1.4	4.0	-1.3	0.1	0.8	-0.6	0.8	2.0	1.9	1.3	-0.5	-1.7	0.1	1.4	0.6
Number of self-reported non-cancer illnesses	0.3	0.6	1.7	0.9	-0.0	1.3	0.8	1.0	0.3	-0.1	-0.4	-1.3	0.9	0.6	-0.7	-0.4
Eye problems/disorders: Glaucoma	0.3	0.4	1.0	-0.9	-0.3	-1.0	0.6	-0.9	-0.3	-0.4	-0.1	0.6	-0.7	-0.7	0.8	-0.3
High cholesterol (Self-reported)	0.3	0.6	2.3	0.5	0.6	-0.2	0.9	-0.7	-0.4	0.5	-0.8	-1.1	1.5	0.3	0.9	0.7
Alcohol drinker status: Never	0.3	0.4	1.5	-1.0	-0.6	-0.4	-0.5	-0.6	0.2	0.3	0.1	-1.2	-0.8	-0.7	0.3	0.2
Basal metabolic rate	0.3	1.7	5.1	-1.1	-0.1	1.0	-0.6	0.9	2.2	2.2	1.2	-0.4	-1.4	0.4	1.5	1.4
Arm fat-free mass (left)	0.3	1.3	4.4	-0.7	-0.1	1.0	-0.7	1.2	2.1	2.1	0.9	-0.7	-1.0	0.5	1.0	1.3
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.5	1.1	1.1	-0.7	1.1	-0.4	-1.1	-1.1	-0.2	0.1	1.2	0.6	-0.5	-1.1
Arm predicted mass (left)	0.3	1.4	4.5	-0.5	-0.2	1.1	-0.4	1.2	2.1	2.0	1.1	-0.5	-0.8	0.6	1.1	1.4
Ever had hysterectomy (womb removed)	0.2	0.3	1.8	0.3	1.4	-0.4	0.1	-0.0	0.2	-0.1	-0.9	-0.3	0.1	0.0	0.0	-0.5
Impedance of leg (right)	0.2	1.0	2.4	-0.6	-0.7	-1.0	-0.1	-1.3	-1.4	-1.6	-1.1	-0.0	0.1	-1.2	-1.3	-0.5
Age when periods started (menarche)	0.2	0.5	2.2	-1.1	-0.6	-0.4	0.4	-1.5	-0.7	-0.6	-0.1	0.7	-0.5	-0.4	1.0	0.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	1.0	0.5	0.5	0.7	1.0	0.5	0.6	0.1	-0.2	-0.3	0.3	0.6	0.7	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.3	-0.1	-0.2	-0.8	0.1	-0.9	-0.1	0.3	0.2	-1.1	0.4	0.1	1.1	1.1
Trunk fat-free mass	0.2	1.0	2.6	-0.7	-1.1	0.7	-0.6	0.7	1.6	1.4	0.9	-1.0	-1.0	0.4	1.0	1.4
Lung cancer (father)	0.2	0.3	1.0	0.2	0.3	0.3	-0.5	0.4	0.0	-0.2	-0.8	-0.7	-0.0	0.4	-1.0	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	3.0	-0.9	0.6	-0.1	0.3	-0.6	-0.6	0.2	-0.6	-1.4	-0.2	-0.5	-0.0	-1.7
Impedance of arm (left)	0.2	0.8	3.0	-1.7	0.7	-0.5	-0.3	-1.1	-0.5	-0.3	-0.2	0.5	-1.2	-1.2	0.2	-1.3
Trunk predicted mass	0.2	1.0	2.5	-0.6	-1.1	0.7	-0.6	0.6	1.6	1.4	0.9	-1.0	-0.9	0.4	1.0	1.3
Length of working week for main job	0.2	0.2	0.8	-0.5	0.9	-0.7	-0.4	-0.3	-0.2	0.4	-0.2	-0.7	-0.1	-0.1	0.1	-0.5
Hair/balding pattern: Pattern 4	0.2	0.6	2.5	-0.7	-0.1	0.7	-1.1	0.9	-0.2	-0.4	-0.3	-0.4	-0.8	0.1	-1.6	-0.7
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.9	-0.2	0.7	0.2	1.0	-0.6	-0.2	0.1	-0.9	0.3	0.4	-0.4	0.3	0.5
Arm fat-free mass (right)	0.2	1.0	3.4	-0.6	-0.5	0.8	-0.3	0.8	1.8	1.6	0.9	-0.8	-0.9	0.5	0.9	1.2
Arm predicted mass (right)	0.2	1.0	3.0	-1.0	-0.7	0.4	-0.3	0.3	1.7	1.5	0.8	-1.0	-1.1	0.2	1.1	1.3
Pulse rate, automated reading	0.2	0.7	3.0	-1.7	-0.3	-0.6	0.1	-0.9	-0.3	-0.1	-0.3	0.3	-1.1	-1.6	-0.8	-0.8
Alcohol intake frequency.	0.2	0.5	2.2	-1.5	-0.2	0.7	0.3	-0.4	0.2	0.5	-0.0	-1.0	-0.7	-1.1	0.5	0.7
Comparative height size at age 10	0.2	1.1	3.4	0.2	0.9	1.3	-0.0	1.4	1.9	1.5	1.2	-0.5	-0.3	1.1	0.4	1.0
Smoking status: Previous	0.2	0.3	1.1	0.0	0.2	1.1	0.7	0.2	-0.1	0.3	-0.2	0.7	0.2	0.2	0.7	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.3	-0.4	0.7	0.7	-0.3	0.8	1.2	1.1	0.6	-0.5	-0.4	0.2	0.5	-0.6
Whole body fat-free mass	0.2	1.2	3.4	-0.9	-0.5	0.8	-0.5	0.8	1.8	1.7	1.1	-0.8	-1.2	0.4	1.2	1.2
Average weekly red wine intake	0.2	0.3	1.8	0.3	-0.2	-1.3	0.8	-0.8	-0.4	-0.4	0.1	-0.4	0.5	0.1	0.7	-0.1
Mood swings	0.2	0.4	1.0	-0.8	-0.6	0.0	0.6	-1.0	-0.3	0.0	-0.4	-0.9	0.0	-0.6	0.9	0.1
Ever had bowel cancer screening	0.2	0.3	1.3	-0.2	0.2	0.3	-0.2	-0.1	-0.6	-0.3	-0.8	-0.5	-0.2	-0.2	-1.2	-0.7
Commuting to job workplace: Walk	0.2	0.2	0.7	0.0	-0.0	-0.8	0.3	-0.5	-0.8	-0.8	-0.4	0.2	0.1	-0.2	-0.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	1.2	-0.1	1.1	1.1	0.5	0.3	-0.3	0.5	-0.3	-0.7	0.5	0.4	0.2	-0.2
Whole body water mass	0.2	1.4	4.1	-0.9	-0.4	1.0	-0.5	0.9	2.0	1.9	1.2	-0.7	-1.3	0.4	1.4	1.3
Medication: Blood pressure	0.2	0.4	1.3	0.8	0.6	-0.3	0.5	-0.3	0.3	0.6	-0.7	0.1	1.1	0.5	0.6	0.8
Medication: Atorvastatin	0.2	0.3	1.1	0.8	0.2	0.6	0.5	0.5	-0.2	-0.1	-0.6	-0.4	1.0	0.5	-0.2	0.6
Pain experienced in last month	0.2	0.4	1.3	-0.2	-0.2	-0.2	-1.1	0.4	-1.0	-0.9	0.3	-0.2	-0.6	-0.1	-0.8	-0.2
Supplements: Calcium	0.2	0.2	1.3	-0.0	0.1	-0.1	-0.3	-0.1	-0.4	-0.5	-0.6	-1.1	-0.4	-0.1	-0.2	-0.5
Heart disease (siblings)	0.2	0.2	0.6	-0.8	-0.0	-0.5	-0.2	-0.7	-0.0	0.4	-0.3	-0.4	-0.4	-0.4	-0.1	0.8
Impedance of whole body	0.2	1.2	3.1	-1.5	0.4	-1.0	-0.5	-1.3	-1.3	-1.0	-1.0	-0.0	-0.8	-1.4	-0.9	-1.8
Prostate Cancer	0.1	0.2	0.9	0.3	0.4	0.1	-0.2	0.3	-0.0	0.4	0.3	0.6	0.3	0.2	-0.3	-1.0
Height	0.1	1.1	3.2	-1.6	-0.5	-0.4	-0.9	-0.3	1.4	1.0	1.3	-0.3	-1.8	-1.4	0.7	0.4
Cardiovascular Disease	0.1	0.2	0.8	-0.1	-0.1	0.4	-0.9	0.7	0.2	0.9	-0.2	-0.4	0.2	-0.7	-0.1	-0.2
Tanning	0.1	1.3	4.3	0.7	2.1	1.1	-0.3	1.7	1.0	1.0	0.5	-0.5	0.6	1.0	-1.1	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.2	-0.7	-0.7	-0.6	0.1	-1.0	-0.1	0.1	0.1	-0.7	-0.1	-0.2	0.6	1.1
Sitting height	0.1	1.0	3.9	-1.2	-0.4	-0.2	-1.9	0.4	1.0	0.6	0.7	-1.4	-2.0	-0.0	-0.3	-0.2
Past tobacco smoking	0.1	0.2	1.1	0.4	-0.7	-1.1	-0.5	-0.3	0.0	-0.6	0.5	-0.1	0.1	-0.1	-0.4	-0.4
Hearing difficulty/problems with background noise	0.1	0.2	0.5	-0.5	-0.2	-0.2	0.2	-0.7	0.0	0.4	-0.6	-0.5	0.0	-0.3	0.7	0.3
Forced vital capacity (FVC)	0.1	0.6	2.7	-0.5	1.0	0.7	0.6	0.2	0.3	0.8	0.3	-1.6	-0.0	0.0	0.3	-1.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.9	-0.2	1.0	0.2	0.9	-0.3	-0.0	0.6	0.2	-1.3	0.4	0.1	0.6	-1.4
Standing height	0.1	1.2	4.2	-1.7	-1.2	-0.1	-1.4	-0.1	1.3	0.7	1.1	-1.1	-2.0	-0.5	0.4	0.1
Breastfed as a baby	0.1	0.2	0.9	-0.5	-0.0	-0.1	-0.2	-0.3	0.4	1.0	-0.2	-0.1	-0.1	-0.4	0.5	-0.2
Pulse wave reflection index	0.1	0.1	0.4	0.1	0.1	-0.1	-0.2	-0.1	-0.0	0.0	-0.6	-0.6	-0.0	0.2	-0.1	0.7
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.3	-0.1	-0.3	-0.3	0.0	0.3	0.4	0.2	0.4	-0.3	0.0	0.2	-0.2
Forced vital capacity (FVC), Best measure	0.1	0.5	2.5	-0.7	1.0	0.6	0.2	0.2	0.1	0.6	-0.2	-1.4	-0.2	-0.3	-0.1	-1.6
Medication: Allopurinol	0.1	0.2	0.6	-0.2	-0.2	0.7	0.3	0.2	0.0	-0.2	0.8	0.3	-0.1	-0.8	-0.6	0.0
Ever smoked	0.1	0.2	0.8	-0.1	0.9	-0.0	0.6	-0.4	-0.6	-0.0	-0.8	-0.1	0.3	0.1	-0.3	-0.5
Hair Pigment	0.0	0.6	3.2	-0.2	-0.6	-0.2	-0.1	-0.5	-0.3	-0.1	-0.7	-1.2	-0.1	0.6	1.3	1.8

Hub : Genes

NDUFS2

Models

Trait associations