Hub : Genes

ADAMTS4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.3470	0.0530	3.5e-13	0.219	NA	0.248	NA	0.260	2.4e-16	NA	1.2e-18	NA	1.5e-19
2	METSIM	Adipose	0.0414	0.0169	7.8e-04	0.019	0.025	0.022	0.024	0.025	6.7e-04	0.00011	2.7e-04	0.00012	9.8e-05
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0615	0.0331	1.1e-03	0.003	0.020	0.024	NA	0.021	1.2e-01	0.00230	8.3e-04	NA	1.9e-03
4	TCGA	Thyroid Carcinoma	0.0430	0.0230	1.1e-03	0.058	0.030	0.046	NA	0.050	2.3e-06	0.00058	2.7e-05	NA	1.2e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.4	2.2	6.1	-1.3	-0.9	0.4	-2.5
Bipolar Disorder or Schizophrenia	1.1	2.6	4.8	-2.2	-0.6	1.0	-2.0
Depressed Affect (Nagel 2018)	0.2	0.4	0.9	-0.9	0.0	0.8	0.5
Depression (Nagel 2018)	1.0	1.5	3.3	-0.3	1.1	1.1	1.8
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	-0.0	0.4	-0.5	-0.7
Neuroticism (Nagel 2018)	0.1	0.3	0.8	-0.4	-0.9	-0.1	-0.6
Schizophrenia (2018)	0.5	1.0	3.1	-1.8	0.0	0.7	-0.6
Schizophrenia vs Biploar Disorder	0.7	0.9	2.2	1.5	0.5	0.4	1.1
Worry (Nagel 2018)	0.3	0.6	2.1	-1.4	-0.3	-0.3	-0.5
Alzheimer’s Disease (in mother)	2.6	3.0	10.0	-3.2	0.3	1.3	0.2
Alzheimer’s Disease (in father)	1.6	1.7	3.1	-1.8	-1.2	-0.4	-1.5
Alzheimer’s Disease (including proxy)	3.9	5.6	21.0	-4.6	-0.7	1.1	-0.2
Crohns Disease (2017)	0.4	0.8	1.3	0.8	1.1	1.0	0.4
Irritable Bowel Disease (IBD)	0.8	2.0	5.0	0.2	1.7	2.2	0.3
Ulcerative Colitis (UC)	0.8	1.4	3.9	-0.2	1.3	2.0	-0.0
Major Depression (MDD)	1.9	2.3	6.2	-1.0	0.9	2.5	1.1
Reaction Time	0.4	0.8	1.7	-0.6	0.6	0.7	-1.3
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.5	-0.9	0.4	-0.9	-1.2
Breast Cancer	0.1	0.3	1.2	0.1	-1.1	0.1	0.1
Ovarian Cancer	0.4	0.5	2.0	1.4	0.2	-0.1	0.3
Prostate Cancer	0.1	0.1	0.2	0.2	-0.4	-0.4	-0.2
Age at First Birth	0.4	0.5	1.6	-0.1	-0.3	-0.7	-1.2
Bipolar Disorder (2011)	0.7	0.7	1.7	-1.3	-0.5	0.0	-0.8
Body Mass Index (BMI) (2010)	0.5	0.7	1.5	0.4	1.2	-0.2	1.1
Coronary Artery Disease (CAD)	0.6	0.7	1.5	-1.0	-0.7	-0.0	-1.2
Crohns Disease (2012)	0.3	0.5	0.8	0.5	0.6	0.9	0.7
Mean Putamen Volume	1.2	1.4	4.4	0.2	2.1	-0.8	0.6
Fasting Glucose	1.3	1.6	4.1	0.8	-0.7	-2.0	-1.0
HbA1C	1.3	1.5	2.5	1.6	-0.4	-1.1	-1.4
HDL Cholesterol	0.4	0.7	1.8	-0.2	-0.4	-0.9	-1.4
LDL Cholesterol	0.2	0.3	1.0	0.1	-0.0	1.0	0.3
Lupus	1.0	1.5	5.7	-2.4	-0.0	0.3	0.5
Neuroticism (2016)	0.4	0.6	1.5	-0.2	-1.0	1.2	-0.3
Primary Biliary Cirrhosis	0.6	0.8	1.5	-0.6	0.8	1.2	0.9
Rheumatoid Arthritis	0.8	1.1	4.0	2.0	0.0	0.3	-0.6
Schizophrenia (2014)	0.5	1.2	3.6	-1.9	-0.8	-0.0	-0.7
Triglycerides	0.8	1.3	2.2	0.8	0.8	1.5	1.3
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.4	0.2	0.5	-0.7	-0.2
Ulcerative Colitis	0.5	0.7	2.2	-0.1	0.8	1.5	0.3
Blood Eosinophil Count	1.5	11.2	42.4	6.5	-0.0	0.4	-1.6
Blood Platelet Count	0.6	6.8	15.4	-3.9	0.2	-3.3	-0.9
Blood Red Count	0.6	6.0	10.5	3.2	3.2	0.9	1.6
Blood White Count	1.9	13.9	22.8	4.7	4.8	1.1	3.0
Heel T-Score	0.2	1.2	1.8	-1.2	1.0	1.4	-0.8
BMI	2.2	12.9	23.7	-1.1	4.9	2.5	4.5
Height	0.1	2.0	2.8	-1.5	0.3	1.6	1.7
Waist Hip Ratio (WHR)	1.3	5.9	10.4	-3.2	-2.4	0.7	-2.7
Systolic Blood Pressure	0.2	1.1	2.9	-0.5	1.1	-0.4	1.7
Smoking Status	0.0	0.0	0.2	0.1	-0.1	0.4	-0.1
Allergy or Eczema	8.9	23.5	51.4	7.2	-3.4	-2.9	-4.8
Cardiovascular Disease	1.0	3.3	8.4	-1.4	1.2	2.9	1.2
Hypothyroidism (self reported)	0.5	1.3	2.8	-0.7	1.7	-0.6	1.2
Respiratory disease	2.5	5.5	19.2	4.4	-0.8	-0.3	-1.4
Type 2 Diabetes (T2D) (2018)	1.5	2.8	3.8	-1.6	1.9	1.0	1.9
Lung FEV1/FVC ratio	0.2	0.9	2.9	-0.6	1.7	-0.4	0.5
Lung FVC	0.2	1.1	3.8	-0.7	1.9	0.4	-0.3
Neuroticism	0.2	0.5	1.5	-1.2	-0.5	-0.3	0.0
Chronotype (morning person)	1.6	3.8	5.6	2.4	-1.7	-1.8	-1.8
Hair Pigment	0.0	1.0	2.0	-1.0	0.8	-1.4	0.6
Tanning	0.0	0.4	0.8	0.9	0.3	0.4	0.6
Hand grip strength (left)	0.7	1.9	2.9	1.7	0.7	1.1	1.7
Number of treatments/medications taken	0.3	0.6	1.4	0.8	-0.6	1.2	-0.1
Average weekly spirits intake	0.6	0.8	1.2	0.3	-1.1	-0.9	-1.0
Sensitivity / hurt feelings	0.4	0.6	1.3	-1.1	-0.9	-0.6	-0.3
Frequency of depressed mood in last 2 weeks	2.7	3.7	6.5	-0.6	1.4	2.5	2.5
Hearing difficulty/problems: Yes	1.7	2.5	7.1	0.6	2.7	0.3	1.6
Relative age of first facial hair	0.1	0.2	0.5	-0.7	-0.4	-0.1	0.0
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.6	-0.1	-0.9	1.2	1.1
Ever used hormone-replacement therapy (HRT)	1.4	1.8	5.2	-0.6	2.3	0.1	1.2
Ever had hysterectomy (womb removed)	0.6	0.7	1.0	-0.5	0.9	1.0	0.8
Systolic blood pressure, automated reading	0.6	1.7	4.7	-1.0	1.1	0.2	2.2
Eye problems/disorders: Diabetes related eye disease	2.6	2.9	5.1	0.1	1.9	1.7	2.2
Angina	0.2	0.3	0.7	0.1	-0.9	-0.1	-0.6
Medication for hormone replacement therapy	0.8	0.8	1.7	1.1	-0.6	0.3	-1.3
Vitamin and mineral supplements	0.9	1.2	2.4	-1.3	-1.6	0.7	0.2
Supplements: Zinc	0.7	0.7	1.2	-0.8	1.1	0.4	1.0
Medication: Co-codamol	2.8	3.3	6.0	-0.6	1.4	2.2	2.4
Medication: Metformin	2.8	4.0	7.0	-1.6	1.4	2.6	2.1
Diabetes (father)	0.3	0.4	1.0	-1.0	-0.5	0.3	0.5
Diabetes (mother)	0.7	0.9	2.9	-1.7	-0.2	0.7	0.0
Severe depression (siblings)	0.5	0.6	1.3	-1.1	-0.4	-0.0	-1.0
Pack years adult smoking proportion	0.7	1.0	2.2	-1.5	1.1	-0.1	0.8
Impedance of leg (right)	0.1	0.3	1.2	0.1	-0.4	0.1	-1.1
Leg fat-free mass (left)	1.1	6.0	12.2	-2.1	2.1	1.7	3.5
Trunk fat percentage	2.2	8.9	15.0	-1.7	3.7	2.0	3.9
Hand grip strength (right)	1.0	2.6	5.6	0.9	1.6	1.2	2.4
Townsend deprivation index at recruitment	0.7	1.0	2.2	-0.2	1.5	0.6	1.2
Current tobacco smoking	0.0	0.0	0.0	-0.2	0.1	0.2	-0.1
Average weekly fortified wine intake	0.3	0.3	0.6	-0.7	-0.1	-0.5	-0.8
Maternal smoking around birth	0.3	0.5	0.8	0.2	-0.9	-0.9	-0.6
Fed-up feelings	0.5	1.0	3.5	-1.9	0.4	0.1	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	3.9	5.2	8.9	-0.8	2.8	1.9	3.0
Relative age voice broke	0.6	0.9	2.6	-1.6	-0.6	0.5	0.7
Taking other prescription medications	0.9	1.5	3.8	1.3	0.3	2.0	0.6
Age when periods started (menarche)	0.3	0.7	1.6	0.6	-1.3	-0.8	-0.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.4	0.4	-0.1	0.3	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.6	0.1	0.8	0.1	-0.3
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	3.1	-1.8	0.6	0.9	0.3
Qualifications: CSEs or equivalent	0.3	0.4	0.8	-0.5	0.9	-0.6	0.3
Serious illness, injury or assault to yourself	0.5	0.6	1.0	0.8	-0.3	1.0	0.9
High blood pressure	1.4	3.9	5.1	-2.3	1.6	1.9	2.1
Hayfever, allergic rhinitis or eczema	6.8	14.8	35.4	6.0	-2.4	-2.3	-3.5
Multivitamins +/- minerals	0.9	1.1	2.7	1.2	1.7	-0.2	-0.6
Stomach or abdominal pain in last month	1.1	1.3	3.3	1.3	1.8	-0.2	0.6
Supplements: Glucosamine	1.1	1.4	2.2	0.8	1.1	-1.5	-1.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.8	0.9	-0.2	-0.4	-0.5
Medication: Atenolol	0.3	0.4	1.2	-0.2	1.1	-0.1	0.7
Medication: Levothyroxine sodium	2.4	4.1	8.5	-0.7	2.9	0.7	2.6
Sitting height	0.2	1.3	3.2	-1.8	-0.8	-0.3	1.1
Chronic bronchitis/emphysema (father)	0.8	0.9	2.1	1.0	-0.7	0.1	-1.4
High blood pressure (mother)	0.1	0.1	0.3	-0.1	-0.4	-0.5	0.2
Body mass index (BMI)	1.6	7.0	11.4	-1.4	3.2	2.0	3.4
Impedance of leg (left)	0.2	1.0	3.0	0.2	-0.8	-0.4	-1.7
Leg predicted mass (left)	1.1	6.0	12.4	-2.0	2.1	1.6	3.5
Trunk fat mass	2.4	10.3	18.0	-2.0	3.8	2.1	4.2
Waist circumference	2.1	7.5	9.8	-3.1	2.7	1.9	3.0
Number of incorrect matches in round	0.5	0.8	2.7	-0.1	1.6	0.1	0.8
Past tobacco smoking	0.4	0.8	1.7	-0.2	-0.4	-1.3	-1.1
Alcohol usually taken with meals	1.4	2.2	5.3	0.7	-1.3	-1.2	-2.3
Nervous feelings	0.6	1.0	3.7	-1.9	0.3	0.6	0.2
Frequency of tenseness / restlessness in last 2 weeks	3.1	4.9	8.4	-1.0	1.8	2.9	2.6
Hearing difficulty/problems with background noise	0.7	1.1	3.6	-0.0	1.9	0.6	0.7
Hair/balding pattern: Pattern 2	1.0	1.3	2.8	-0.2	1.6	0.2	1.7
Had menopause	0.3	0.4	0.8	0.2	0.8	-0.1	-0.9
Had other major operations	1.5	1.8	4.1	-0.6	1.4	0.9	2.0
Forced vital capacity (FVC)	0.6	2.3	4.7	-0.4	2.2	1.0	1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.3	0.6	0.4	0.6	-0.5	-0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	0.9	-0.7	0.9	-0.7	0.1
Qualifications: None of the above	0.2	0.4	1.3	-0.4	-0.2	0.2	1.1
Financial difficulties in last 2 years	6.5	8.7	10.9	-3.0	2.4	3.3	3.1
Mouth/teeth dental problems	5.8	9.0	18.0	-2.6	2.3	2.4	4.2
Heart attack	1.1	1.4	4.4	2.1	-1.1	0.2	-0.1
Allergy	5.3	12.2	32.9	-5.7	2.1	0.8	3.3
Pain all over the body in last month	4.6	4.9	7.1	-1.9	2.5	1.7	2.7
Diabetes (self-reported)	1.7	2.6	3.9	-0.5	1.9	1.6	2.0
Hayfever/allergic rhinitis (self-reported)	9.1	12.0	26.1	5.1	-3.4	-1.0	-3.0
Medication: Ramipril	0.5	0.6	1.3	-0.1	1.1	-0.5	0.9
Medication: Simvastatin	1.0	1.5	4.7	0.2	0.7	2.2	0.8
Fluid intelligence score	0.7	1.4	2.5	-0.7	-1.0	-1.2	-1.6
Illnesses of siblings	2.0	2.8	4.4	0.9	-2.1	-1.7	-1.8
Neuroticism score	0.2	0.4	1.0	-1.0	-0.7	-0.4	-0.2
Weight	1.8	8.6	16.1	-2.1	3.2	2.0	4.0
Impedance of arm (right)	0.1	0.4	1.2	-0.3	-1.1	0.3	-0.3
Arm fat percentage (right)	2.0	7.7	12.6	-1.5	3.5	2.0	3.5
Trunk fat-free mass	0.5	3.2	5.8	-2.0	1.3	0.9	2.4
Hip circumference	2.0	8.5	18.1	-1.2	3.5	1.4	4.2
Time employed in main current job	0.6	0.6	1.4	-0.4	0.1	1.2	1.0
Alcohol intake versus 10 years previously	1.5	2.3	5.1	-0.6	2.3	1.2	1.4
Father’s age at death	1.5	2.0	5.9	0.8	-1.1	-0.6	-2.4
Worrier / anxious feelings	0.5	1.0	2.8	-0.8	-1.7	0.1	-0.7
Frequency of tiredness / lethargy in last 2 weeks	3.0	4.9	7.3	-0.8	2.1	2.7	2.7
Falls in the last year	0.5	0.7	2.5	-0.3	-0.1	1.6	0.2
Hair/balding pattern: Pattern 3	0.7	1.0	1.4	1.2	-1.0	0.0	-1.2
Number of live births	0.2	0.3	1.1	-0.4	-0.0	1.0	-0.2
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	6.1	-0.6	2.5	0.8	2.0
Pulse rate	0.8	1.4	4.5	-0.8	-0.0	2.1	0.8
Happiness	0.5	0.7	1.0	-0.8	0.2	1.0	1.0
Noisy workplace	1.3	1.6	2.9	0.6	0.7	1.7	1.6
Qualifications: A levels/AS levels or equivalent	0.6	1.4	3.8	0.4	-1.2	-0.2	-1.9
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	3.4	-1.4	-1.8	1.9	0.5
Mouth/teeth dental problems: Dentures	5.0	8.4	23.2	4.8	-1.2	-1.8	-2.4
Asthma	2.6	5.1	18.5	4.3	-0.1	0.5	-1.3
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	4.8	0.9	1.3	2.2	1.4
Medication: Cholesterol lowering	0.4	0.6	1.9	0.3	-0.6	1.4	-0.2
Depression (self-reported)	0.7	0.9	2.7	-0.6	0.2	1.6	0.7
Medication: Lansoprazole	0.1	0.1	0.4	-0.6	0.1	0.2	-0.2
Prospective memory result	0.6	0.8	1.6	0.2	1.3	0.7	1.0
Lung cancer (father)	0.4	0.5	1.0	0.5	0.9	-1.0	-0.3
Illnesses of mother	1.3	1.7	4.7	1.1	-0.7	-2.2	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	5.9	-1.2	2.4	1.2	2.2
Pulse wave Arterial Stiffness index	0.7	0.9	1.5	-0.6	0.6	1.2	1.1
Impedance of arm (left)	0.0	0.1	0.5	0.2	-0.7	0.0	-0.0
Arm fat mass (right)	2.2	9.2	15.3	-1.9	3.6	2.2	3.9
Trunk predicted mass	0.6	3.2	5.8	-2.0	1.3	1.0	2.4
Standing height	0.1	1.4	3.4	-1.9	-0.0	-0.0	1.5
Length of working week for main job	0.0	0.1	0.2	-0.1	0.1	-0.1	0.4
Exposure to tobacco smoke at home	1.5	1.6	5.2	-0.5	0.8	0.8	2.3
Breastfed as a baby	2.6	3.2	4.4	-2.0	1.8	1.1	2.1
Tense / ‘highly strung’	1.9	3.2	6.8	-2.6	0.9	1.3	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.8	-0.6	-0.6	0.9	-0.5
Hair/balding pattern: Pattern 4	0.4	1.1	2.8	0.5	0.3	-1.7	-1.1
Birth weight of first child	0.5	1.0	2.7	-1.6	-0.3	0.7	-0.8
Peak expiratory flow (PEF)	0.4	0.9	2.4	1.5	0.2	-1.0	-0.6
Pulse wave reflection index	0.3	0.4	0.7	-0.8	0.6	-0.1	0.8
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	-0.6	0.4	-0.1	0.3
Loud music exposure frequency	0.3	0.3	1.1	-0.1	1.1	-0.1	-0.2
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	5.8	-2.4	0.9	-0.1	0.9
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	4.1	-0.1	-1.5	-1.4	-2.0
Blood clot in the leg (DVT)	2.6	3.3	13.0	-0.4	-0.0	3.6	0.4
Medication: Paracetamol	3.6	6.0	12.6	-1.1	2.3	2.2	3.5
Headache pain in last month	1.9	3.2	7.3	0.5	2.2	0.7	2.7
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	4.1	0.2	-0.7	-2.0	-1.2
Glaucoma (self-reported)	0.7	0.8	2.8	-0.4	-0.3	1.7	0.6
Gout (self-reported)	0.7	1.0	3.0	1.7	-0.1	0.8	-0.7
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	5.1	-1.1	2.3	-0.1	1.6
Medication: Amlodipine	0.3	0.4	0.7	-0.6	-0.2	-0.8	0.9
Medication: Ventolin 100micrograms inhaler	2.8	3.6	12.8	3.6	-0.1	0.8	-1.0
Birth weight	0.8	1.6	6.0	-0.1	0.3	0.8	2.4
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.6	0.5	0.8	0.6	0.4
High blood pressure (siblings)	2.5	3.6	5.5	-1.1	2.4	1.4	2.4
Forced vital capacity (FVC), Best measure	0.8	3.1	5.0	-0.7	2.2	1.4	2.2
Body fat percentage	2.3	9.1	14.7	-1.8	3.8	2.0	3.8
Leg fat percentage (right)	1.9	6.9	12.6	-1.5	3.5	1.9	3.0
Arm fat-free mass (right)	0.8	4.0	7.8	-1.9	1.8	1.2	2.8
Exposure to tobacco smoke outside home	0.5	0.7	1.3	-1.1	-0.3	-0.8	0.8
Comparative body size at age 10	1.7	4.6	12.3	0.1	3.5	0.3	2.5
Number of full brothers	0.4	0.5	1.8	-0.3	-0.0	1.4	0.1
Worry too long after embarrassment	0.7	1.2	3.7	-0.9	-1.9	-0.3	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.9	5.3	-2.3	-0.7	1.1	-0.4
Wheeze or whistling in the chest in last year	0.6	1.1	4.1	2.0	0.7	0.2	0.0
Number of children fathered	1.2	1.4	2.5	0.6	0.8	-1.5	1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.6	-0.4	0.0	-0.9	1.6
Age at first live birth	1.9	3.4	8.9	0.8	-1.7	-1.0	-3.0
Pulse wave peak to peak time	0.6	0.7	1.1	0.5	-0.7	-1.1	-0.9
Health satisfaction	4.0	5.2	9.1	-2.5	1.6	1.8	3.0
Shortness of breath walking on level ground	2.0	2.4	4.4	-1.0	0.9	2.1	1.8
Qualifications: College or University degree	1.1	3.5	7.3	1.6	-1.9	-0.7	-2.7
Eye problems/disorders: None of the above	0.1	0.1	0.3	-0.5	0.1	-0.4	-0.1
Mouth/teeth dental problems: Loose teeth	2.6	3.1	9.8	3.1	-1.4	0.7	-0.7
Emphysema/chronic bronchitis	0.6	0.6	1.5	-0.4	0.8	1.2	0.5
Medication for pain relief, constipation, heartburn	2.0	3.4	6.4	-0.5	-1.6	-2.1	-2.5
Neck or shoulder pain in last month	0.1	0.2	0.4	0.4	-0.3	-0.6	0.4
Medication: Blood pressure	0.8	1.5	3.2	-0.4	1.3	1.0	1.8
Angina (self-reported)	0.1	0.1	0.4	-0.1	-0.6	0.1	-0.3
Migraine (self-reported)	0.4	0.6	0.8	-0.9	0.5	0.7	0.8
Medication: Ibuprofen	2.0	2.3	5.7	0.4	1.2	2.4	1.5
Medication: Allopurinol	0.5	0.7	1.8	0.9	0.2	1.3	0.0
Medication: Omeprazole	0.3	0.3	0.6	-0.7	0.2	0.5	0.6
Medication: Seretide 50 evohaler	0.4	0.5	1.3	1.1	0.5	0.4	0.5
Mean time to correctly identify matches	0.7	1.3	5.0	-0.2	-0.2	-0.3	-2.2
Heart disease (mother)	0.5	0.6	1.4	-0.3	0.5	1.2	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.5	0.2	0.7	0.5	1.6
Whole body fat mass	2.4	10.0	16.3	-2.3	3.8	2.0	4.0
Leg fat mass (right)	2.5	9.8	15.6	-2.1	4.0	2.3	3.7
Arm predicted mass (right)	0.9	4.6	8.1	-2.0	2.1	1.3	2.8
Pulse rate, automated reading	0.7	2.2	6.3	-0.5	-0.7	2.5	1.3
Alcohol intake frequency.	1.0	2.3	4.5	-0.7	2.1	1.7	1.2
Comparative height size at age 10	0.7	3.7	5.7	-1.1	2.4	1.4	2.4
Number of full sisters	4.8	5.8	12.8	-1.7	1.6	2.3	3.6
Suffer from ‘nerves’	1.4	2.2	4.0	-2.0	1.4	1.3	1.0
Overall health rating	3.8	8.2	14.6	-1.0	2.7	3.2	3.8
Chest pain or discomfort	0.7	1.1	1.9	-0.8	0.2	1.4	1.3
Had major operations	0.3	0.3	1.3	0.0	0.1	-0.0	1.1
Age at last live birth	1.5	2.2	5.0	-0.2	-1.9	-0.3	-2.2
Family relationship satisfaction	1.8	2.2	3.7	-1.9	0.6	1.2	1.8
Leg pain on walking	0.6	0.7	1.4	-1.2	0.5	1.0	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.4	-0.1	-0.3	-1.2	-0.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.7	0.2	0.8	-0.4	0.1
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	3.2	0.1	-0.1	-1.8	-1.2
Medication: Aspirin	0.6	0.8	3.1	1.8	-0.1	0.5	-0.2
Supplements: Vitamin C	1.2	1.4	3.2	-0.8	1.3	-0.2	1.8
Knee pain experienced in last month	0.1	0.1	0.2	-0.3	-0.5	0.3	0.2
Hypertension (Self-reported)	1.3	3.7	4.8	-2.2	1.6	1.9	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.9	0.4	0.2	0.9	1.4
Illnesses of father: Heart disease	0.1	0.2	0.6	-0.0	-0.4	0.8	-0.2
Illnesses of siblings: Diabetes	5.3	6.5	9.3	-2.1	2.4	2.6	3.0
Smoking status: Previous	0.2	0.3	0.7	0.5	-0.0	0.8	0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.8	6.1	-1.3	1.1	1.5	2.5
Whole body fat-free mass	0.7	4.1	8.4	-2.0	1.6	1.2	2.9
Leg fat-free mass (right)	0.8	4.5	9.5	-1.9	1.6	1.4	3.1
Arm fat percentage (left)	2.0	8.1	13.6	-1.4	3.6	1.9	3.7
Average weekly red wine intake	0.8	1.1	1.7	1.3	-1.2	-0.6	-1.0
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.2	-0.9	0.7	1.5	0.4
Mood swings	0.3	0.5	1.1	-0.4	0.8	1.1	0.4
Loneliness, isolation	1.3	1.8	3.6	-0.6	1.3	1.3	1.9
Long-standing illness, disability or infirmity	4.2	6.5	14.1	-0.5	1.8	3.8	2.9
Ever had bowel cancer screening	0.3	0.4	0.9	-0.5	0.9	0.5	-0.4
Diabetes diagnosed by doctor	1.6	2.6	3.5	-1.4	1.6	1.4	1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	-0.2	0.0	0.0	0.5
Friendships satisfaction	1.9	2.4	4.5	-2.1	1.9	0.8	0.8
Qualifications: nursing, teaching	0.2	0.3	0.8	-0.3	0.1	0.5	-0.9
Commuting to job workplace: Walk	0.6	0.6	1.0	1.0	-0.2	-0.7	-1.0
Eye problems/disorders: Cataract	0.2	0.2	0.7	0.9	-0.1	0.1	-0.5
Mouth/teeth dental problems: Mouth ulcers	4.6	7.3	17.1	-0.5	-2.1	-2.7	-4.1
Medication for cholesterol	0.4	0.6	2.0	-0.1	-0.8	-1.4	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.5	5.0	2.2	0.2	-0.8	-0.3
Back pain experienced in last month	1.2	1.7	5.7	-0.1	0.8	2.4	0.7
Mineral and other dietary supplements	1.5	2.0	3.9	-1.4	-0.4	2.0	1.4
Breast cancer (self-reported)	3.3	3.9	8.9	0.7	-1.8	-1.7	-3.0
Asthma (self-reported)	2.5	5.0	18.1	4.3	-0.4	0.4	-1.3
Osteoporosis (self-reported)	1.1	1.4	3.0	-0.6	1.3	-1.7	0.8
Osteoarthritis (self-reported)	2.3	2.9	6.6	-0.4	1.6	1.6	2.6
Medication: Aspirin	0.9	1.2	3.3	1.8	-0.9	0.2	-0.9
Medication: Gliclazide	1.8	2.1	3.3	-1.8	1.1	0.8	1.8
Illnesses of father: None of the above (group 1)	0.4	0.4	1.5	-0.1	-0.5	-1.2	-0.1
Smoking status: Current	0.0	0.0	0.0	0.1	0.2	0.1	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	4.6	-0.0	2.1	-0.2	1.2
Whole body water mass	0.8	4.6	9.5	-2.0	1.8	1.3	3.1
Leg predicted mass (right)	0.8	4.5	9.7	-1.9	1.6	1.4	3.1
Arm fat mass (left)	2.6	10.6	18.2	-2.0	3.9	2.3	4.3
Number of self-reported non-cancer illnesses	0.5	0.9	3.0	0.7	-0.3	1.7	0.2
Average weekly champagne plus white wine intake	1.3	1.7	3.1	-0.1	-1.2	-1.8	-1.5
Miserableness	0.3	0.6	1.8	-1.3	0.6	0.4	-0.1
Guilty feelings	1.6	2.4	5.5	1.4	-2.3	-0.4	-1.4
Wears glasses or contact lenses	0.8	0.9	1.7	-0.9	-0.4	-0.9	-1.3
Ever taken oral contraceptive pill	0.2	0.2	0.4	0.6	-0.4	0.1	-0.4
Hearing aid user	1.3	1.5	3.2	-0.4	0.9	-1.8	-1.3
Mother’s age at death	0.3	0.4	0.7	0.1	-0.3	-0.9	-0.8
Financial situation satisfaction	4.6	5.7	9.2	-2.5	1.7	2.0	3.0
Tinnitus: Yes, now most or all of the time	1.7	2.0	3.3	1.8	1.3	0.9	1.4
Commuting to job workplace: Public transport	0.6	0.8	1.6	0.2	-1.3	0.7	-0.9
Eye problems/disorders: Glaucoma	0.3	0.4	1.3	0.3	-1.1	0.4	-0.3
Medication: Blood pressure	0.3	0.6	1.3	-0.6	1.2	0.5	0.7
Pain type(s) experienced in last month: Hip pain	1.8	2.2	4.2	1.2	-2.0	-0.3	-1.8
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.8	1.4	0.4	-1.1	-0.6
High cholesterol (Self-reported)	0.4	0.7	1.8	-0.2	0.9	1.4	0.5
Medication: Bendroflumethiazide	0.7	1.1	2.7	-0.4	1.7	0.8	0.9
Medication: Paracetamol	1.2	1.9	4.8	-0.5	1.4	0.8	2.2
Medication: Lisinopril	0.3	0.4	0.8	-0.3	0.4	0.9	-0.6
Medication: Atorvastatin	0.5	0.6	1.0	1.0	-0.0	0.6	-1.0
Illnesses of father: High blood pressure	3.6	4.5	5.8	-1.7	2.0	2.4	2.3
Alcohol drinker status: Never	1.2	1.4	2.1	-1.4	1.5	0.5	1.1
Ever smoked	0.3	0.5	1.3	0.3	0.6	1.1	0.6
Basal metabolic rate	1.1	6.0	12.0	-2.1	2.3	1.6	3.5
Leg fat percentage (left)	1.7	6.2	11.8	-1.7	3.4	1.6	2.8
Arm fat-free mass (left)	1.1	5.8	10.6	-2.2	2.3	1.5	3.2
Number of operations (self-reported)	0.4	0.6	2.0	0.2	0.4	-0.5	1.4
Average weekly beer plus cider intake	1.6	2.3	3.4	-1.7	0.2	1.7	1.9
Irritability	0.1	0.2	0.7	0.4	0.3	-0.2	0.8
Risk taking	1.7	2.5	7.0	-2.7	1.0	1.1	0.9
Ever had prostate specific antigen (PSA) test	2.7	3.2	4.2	1.9	-1.6	-1.5	-2.0
Fractured/broken bones in last 5 years	0.6	0.8	2.1	0.5	0.8	0.5	1.5
Age started oral contraceptive pill	0.3	0.4	1.4	-1.2	-0.1	-0.3	-0.3
Diastolic blood pressure, automated reading	0.9	2.9	6.5	-2.5	0.9	0.1	2.1
Ever depressed for a whole week	1.2	1.4	4.4	-2.1	0.3	0.7	0.8
Unable to work because of sickness or disability	4.5	5.8	6.7	-2.6	2.1	2.5	2.4
Commuting to job workplace: Cycle	0.1	0.1	0.3	0.1	-0.6	-0.3	-0.2
Myopia	0.1	0.2	0.3	-0.5	0.1	-0.6	0.5
Vascular/heart problems diagnosed by doctor	0.8	2.1	3.1	1.5	-1.0	-1.8	-1.5
Cholesterol lowering medication	0.7	1.1	2.7	0.4	1.6	1.0	0.6
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.7	-0.6	0.0	0.7	1.3
Pain experienced in last month	2.5	4.1	7.1	1.2	-1.8	-2.7	-2.2
Supplements: Calcium	0.3	0.3	0.6	0.2	-0.4	-0.8	-0.8
Basal cell carcinoma (self-reported)	0.1	0.2	0.5	0.7	0.3	0.2	0.3
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.4	1.6	-1.1	0.3	-0.1
Deep venous thrombosis (DVT) (self-reported)	2.8	3.6	13.6	-0.5	0.3	3.7	0.6
Heart disease (siblings)	0.4	0.5	1.2	-0.8	1.1	0.4	0.1
Alcohol drinker status: Previous	0.3	0.3	1.0	-1.0	0.2	-0.4	-0.0
Pack years of smoking	0.8	1.1	1.8	-1.3	1.3	-0.6	0.8
Impedance of whole body	0.0	0.2	0.4	0.1	-0.6	-0.1	-0.7
Leg fat mass (left)	2.3	9.0	14.8	-2.1	3.8	2.1	3.5
Arm predicted mass (left)	0.9	4.8	9.4	-1.9	2.1	1.4	3.1