Best TWAS P=2.9e-11 · Best GWAS P=8.14e-19 conditioned to 7.43e-24
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PHF11 | 0.06 | 0.00 | enet | 19 | 0.01 | 4.4e-02 | -0.73 | 5.4 | 7.0e-08 | -0.11 | 0.08 | 0.04 | TRUE |
| 2 | GTEx | Brain Cerebellum | EBPL | 0.50 | 0.30 | enet | 23 | 0.36 | 1.8e-11 | -4.50 | 5.1 | 3.0e-07 | -0.02 | 0.87 | 0.01 | FALSE |
| 3 | GTEx | Brain Cortex | EBPL | 0.36 | 0.08 | enet | 24 | 0.14 | 1.5e-04 | -4.50 | 6.5 | 7.8e-11 | -0.04 | 0.20 | 0.07 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | EBPL | 0.41 | 0.36 | lasso | 10 | 0.37 | 3.8e-13 | 4.71 | 5.2 | 2.0e-07 | 0.02 | 0.99 | 0.00 | FALSE |
| 5 | GTEx | Heart Atrial Appendage | EBPL | 0.17 | 0.04 | lasso | 5 | 0.05 | 2.2e-03 | -4.50 | 5.6 | 2.4e-08 | -0.02 | 0.25 | 0.10 | FALSE |
| 6 | GTEx | Pancreas | EBPL | 0.18 | 0.10 | enet | 5 | 0.09 | 1.6e-04 | -4.50 | 5.5 | 4.7e-08 | 0.00 | 0.38 | 0.03 | FALSE |
| 7 | GTEx | Small Intestine Terminal Ileum | EBPL | 0.39 | 0.10 | lasso | 8 | 0.14 | 4.3e-04 | 4.71 | 5.6 | 2.2e-08 | 0.04 | 0.07 | 0.08 | FALSE |
| 8 | GTEx | Thyroid | EBPL | 0.36 | 0.14 | enet | 33 | 0.30 | 5.1e-23 | -2.62 | 5.4 | 7.3e-08 | 0.04 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Whole Blood | EBPL | 0.12 | 0.06 | lasso | 5 | 0.10 | 1.8e-09 | -3.69 | 5.2 | 2.2e-07 | -0.12 | 0.96 | 0.01 | FALSE |
| 10 | NTR | Blood | EBPL | 0.07 | 0.03 | blup | 401 | 0.04 | 3.8e-13 | -3.88 | 6.7 | 2.9e-11 | -0.07 | 1.00 | 0.00 | TRUE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | EBPL | 0.43 | 0.28 | lasso | 8 | 0.43 | 7.3e-60 | -2.62 | 5.4 | 6.4e-08 | -0.04 | 1.00 | 0.00 | FALSE |
| 12 | YFS | Blood | EBPL | 0.52 | 0.36 | lasso | 8 | 0.48 | 4.8e-183 | 4.71 | 5.6 | 2.0e-08 | -0.05 | 1.00 | 0.00 | FALSE |
| 13 | The Cancer Genome Atlas | Glioblastoma Multiforme | EBPL | 0.45 | 0.24 | blup | 59 | 0.24 | 5.3e-08 | 4.71 | 5.8 | 8.4e-09 | 0.00 | 0.08 | 0.83 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | DLEU1 | 0.13 | 0.04 | lasso | 3 | 0.04 | 2.6e-03 | -6.48 | 6.0 | 2.4e-09 | -0.05 | 0.24 | 0.03 | TRUE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EBPL | 0.22 | 0.12 | enet | 7 | 0.18 | 2.5e-20 | -3.88 | 5.2 | 2.2e-07 | -0.02 | 0.86 | 0.12 | FALSE |
| 16 | The Cancer Genome Atlas | Stomach Adenocarcinoma | EBPL | 0.10 | 0.07 | enet | 7 | 0.08 | 2.8e-06 | -4.50 | 6.2 | 5.9e-10 | -0.02 | 0.16 | 0.33 | FALSE |
| 17 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | DLEU1 | 0.32 | -0.01 | enet | 21 | 0.12 | 5.6e-05 | -0.86 | 5.2 | 1.7e-07 | 0.04 | 0.03 | 0.60 | FALSE |