Hub : Genes

PHF11

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0530	0.0220	1.1e-03	0.022	0.022	0.016	0.023	0.019	8.9e-04	9.0e-04	3.9e-03	6.7e-04	1.8e-03
2	GTEx	Adipose Subcutaneous	0.0620	0.0290	7.4e-03	-0.003	NA	0.010	NA	0.001	7.2e-01	NA	4.4e-02	NA	2.7e-01
3	GTEx	Artery Tibial	0.0971	0.0413	2.1e-03	0.010	NA	0.031	NA	0.016	5.2e-02	NA	1.6e-03	NA	1.8e-02
4	GTEx	Cells Transformed fibroblasts	0.0960	0.0440	2.6e-03	0.081	NA	0.049	NA	0.057	1.2e-06	NA	1.4e-04	NA	4.2e-05
5	GTEx	Lung	0.0811	0.0364	2.1e-03	0.034	NA	0.010	NA	0.001	1.2e-03	NA	5.5e-02	NA	2.4e-01
6	GTEx	Muscle Skeletal	0.1055	0.0296	2.4e-09	0.142	NA	0.112	NA	0.130	7.7e-14	NA	4.6e-11	NA	9.4e-13
7	GTEx	Thyroid	0.1200	0.0550	8.2e-03	0.046	NA	0.012	NA	0.025	1.9e-04	NA	3.7e-02	NA	4.8e-03
8	METSIM	Adipose	0.1642	0.0430	2.8e-16	0.145	0.114	0.135	0.130	0.136	5.2e-21	1.0e-16	1.1e-19	6.8e-19	8.7e-20
9	NTR	Blood	0.0438	0.0128	3.0e-12	0.034	0.037	0.035	0.038	0.038	2.8e-11	6.1e-12	2.4e-11	3.1e-12	3.2e-12
10	YFS	Blood	0.1612	0.0335	0.0e+00	0.161	0.147	0.154	0.154	0.157	2.0e-50	1.0e-45	5.9e-48	5.3e-48	5.0e-49
11	TCGA	Kidney Renal Clear Cell Carcinoma	0.0429	0.0212	4.3e-04	0.050	0.035	0.039	NA	0.049	2.3e-06	7.2e-05	2.8e-05	NA	3.0e-06
12	TCGA	Liver Hepatocellular Carcinoma	0.1270	0.0520	1.2e-06	0.128	0.116	0.094	NA	0.066	1.4e-06	4.3e-06	3.5e-05	NA	4.9e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	1.4	2.1	6.4	-0.3	-1.3	-2.2	-0.8	-2.5	-1.4	-0.6	-1.5	-1.6	-1.4	0.3	1.7
Bipolar Disorder or Schizophrenia	1.8	4.3	11.0	-0.7	-3.1	-3.3	-1.5	-3.2	-1.4	-1.3	-1.6	-2.0	-1.4	-1.0	2.3
Depressed Affect (Nagel 2018)	0.7	1.4	3.1	-1.5	1.3	0.5	-0.3	1.1	1.8	-0.5	1.7	0.4	1.5	-1.4	-0.8
Depression (Nagel 2018)	0.2	0.3	1.7	-1.3	1.2	0.6	0.3	-0.1	0.3	0.2	0.2	0.1	0.2	-0.3	-0.4
Intelligence (Savage-Jansen 2018)	3.5	10.6	23.1	-4.8	-1.5	-2.5	-3.6	-0.0	3.5	-3.4	3.3	4.2	3.7	-1.9	-3.8
Neuroticism (Nagel 2018)	0.5	1.2	3.5	-1.9	-0.3	-0.9	-0.7	-0.1	1.6	-0.9	1.6	0.0	1.1	-1.6	-0.2
Schizophrenia (2018)	1.2	2.6	8.7	-0.7	-3.0	-2.5	-1.3	-2.0	-0.7	-1.2	-0.8	-1.3	-0.6	-1.6	1.6
Schizophrenia vs Biploar Disorder	1.3	1.7	4.6	-1.7	-1.7	-0.6	-1.4	-0.9	0.5	-1.1	0.4	2.2	1.0	-1.3	-1.6
Worry (Nagel 2018)	0.7	1.5	4.0	-1.9	-1.0	-2.0	-1.0	-0.5	1.3	-1.1	1.2	-0.3	1.0	-1.6	0.2
Alzheimer’s Disease (in mother)	2.5	3.0	6.5	-0.2	-2.3	0.2	0.9	-1.1	-2.4	1.2	-2.6	-1.7	-2.3	1.2	2.1
Alzheimer’s Disease (in father)	1.1	1.2	3.4	-0.1	-1.0	-1.2	0.2	-1.9	-1.0	0.2	-0.9	-1.7	-1.0	-0.0	1.6
Alzheimer’s Disease (including proxy)	1.7	2.5	6.1	-0.5	-2.5	-0.6	0.6	-2.0	-1.7	0.8	-1.9	-1.9	-1.8	1.0	2.1
Crohns Disease (2017)	1.5	3.3	6.0	1.8	-0.8	0.8	1.6	-1.0	-2.4	1.6	-2.4	-2.4	-2.1	1.3	2.3
Irritable Bowel Disease (IBD)	0.4	0.9	4.1	2.0	0.4	1.0	0.8	0.3	-1.1	0.6	-1.0	-1.1	-0.7	0.4	0.8
Ulcerative Colitis (UC)	0.4	0.7	1.8	1.3	1.3	1.3	0.1	0.9	0.5	-0.1	0.6	0.7	0.8	-0.3	-0.9
Major Depression (MDD)	1.8	2.1	6.0	-1.7	-0.2	-1.8	-2.1	0.6	1.2	-2.2	1.0	0.3	0.9	-2.4	-1.0
Reaction Time	0.3	0.6	1.6	0.3	-0.2	-1.2	-1.3	-0.2	0.4	-1.2	0.5	0.6	0.4	-0.9	-0.6
Verbal and Numeric Reasoning (VNR)	3.0	7.3	18.6	-4.3	-1.8	-2.2	-3.2	-0.0	2.1	-3.0	1.9	3.6	2.5	-1.6	-3.4
Breast Cancer	0.3	0.8	2.1	-0.5	1.4	1.2	0.9	0.5	0.5	1.0	0.5	0.8	0.6	1.5	-0.7
Ovarian Cancer	0.4	0.5	1.8	0.4	0.2	0.9	0.8	0.4	0.8	0.8	0.7	1.4	0.5	0.8	-0.7
Prostate Cancer	1.9	2.7	6.2	-0.1	1.0	1.3	0.3	2.0	2.4	0.1	2.5	2.2	2.2	0.3	-1.9
Age at First Birth	0.9	1.3	6.5	-0.9	-1.2	-2.5	-1.7	-0.7	0.1	-1.6	0.0	-0.1	0.2	-1.1	0.2
Bipolar Disorder (2011)	1.1	1.1	2.6	-0.6	-1.3	-1.5	-0.7	-1.6	-0.7	-0.6	-0.8	-1.0	-0.8	-0.2	1.5
Body Mass Index (BMI) (2010)	0.6	0.8	2.5	0.9	0.3	0.8	1.1	-0.9	-0.5	1.3	-0.5	-0.5	-0.8	1.1	1.6
Coronary Artery Disease (CAD)	2.9	3.5	6.1	1.3	0.5	1.2	2.1	-2.2	-2.2	2.2	-2.1	-1.2	-1.6	2.5	2.2
Crohns Disease (2012)	0.7	1.2	2.5	1.6	-0.8	1.0	1.2	0.2	-1.2	1.1	-1.3	-1.2	-1.1	0.8	1.0
Mean Putamen Volume	2.8	3.1	7.0	-1.7	0.6	-1.3	-1.4	1.1	2.6	-1.5	2.6	1.8	2.4	-1.3	-1.7
Fasting Glucose	0.2	0.3	0.9	-1.0	0.9	-0.1	-0.1	0.3	0.2	-0.3	0.2	0.6	0.8	0.3	-0.5
HbA1C	0.8	0.8	2.0	-0.3	-1.0	-0.7	-0.4	-1.0	-1.2	-0.5	-1.2	-1.4	0.9	-0.6	1.1
HDL Cholesterol	0.1	0.1	0.3	-0.2	-0.3	-0.4	0.1	0.0	-0.3	0.1	-0.4	0.0	-0.5	0.5	0.4
LDL Cholesterol	1.4	2.2	5.8	0.8	-2.4	-0.8	-0.3	-1.8	-1.6	-0.1	-1.5	-2.0	-1.5	-1.0	2.1
Lupus	0.3	0.5	1.6	0.8	0.7	0.8	-0.4	1.3	0.5	-0.4	0.5	-0.1	0.1	-1.1	-0.1
Neuroticism (2016)	0.7	1.0	2.9	-0.2	-0.6	1.1	-0.0	1.7	1.2	0.0	1.2	0.3	1.2	-1.6	-0.5
Primary Biliary Cirrhosis	1.7	2.4	11.1	3.3	1.3	1.2	1.6	0.9	-1.1	1.6	-0.9	-1.2	-1.2	1.5	1.4
Rheumatoid Arthritis	0.4	0.6	2.2	1.4	-0.4	0.6	0.7	1.5	-0.6	0.6	-0.5	-0.7	-0.3	0.4	0.5
Schizophrenia (2014)	1.2	2.5	7.8	-0.4	-2.8	-2.3	-1.3	-1.8	-1.1	-1.2	-1.2	-1.6	-0.8	-1.5	1.8
Triglycerides	0.7	1.1	2.7	-0.6	-1.3	-1.7	-1.6	-1.4	0.3	-1.4	0.5	0.1	0.5	-1.1	-0.5
Type 2 Diabetes (T2D) (2012)	2.6	3.0	6.3	-1.6	-0.2	-2.0	-2.5	0.8	1.7	-2.5	1.7	0.6	1.8	-2.3	-1.0
Ulcerative Colitis	0.5	0.7	1.2	0.5	0.6	0.2	-0.7	1.0	0.9	-0.8	0.9	0.4	1.1	-1.0	-0.9
Blood Eosinophil Count	1.1	8.2	29.1	0.8	5.4	3.3	0.9	3.9	2.9	0.4	3.1	2.0	3.2	-1.6	-2.5
Blood Platelet Count	2.0	23.1	49.3	-2.0	7.0	2.5	-2.8	4.7	5.7	-3.1	5.8	5.6	5.3	-3.2	-6.5
Blood Red Count	0.4	3.7	10.6	0.4	-0.3	-1.4	-0.1	-2.8	-2.3	-0.0	-2.4	-2.9	-2.1	0.1	3.2
Blood White Count	2.9	21.7	52.7	-2.5	7.3	3.8	-1.4	4.2	5.3	-2.0	5.7	6.2	5.4	-1.5	-5.8
Heel T-Score	0.9	6.8	15.3	3.9	-2.5	-3.5	-0.5	-1.4	-2.5	-0.4	-2.0	-3.3	-2.6	1.6	3.9
BMI	0.2	1.1	2.4	-0.7	1.3	1.4	0.3	0.2	1.3	0.0	1.2	0.5	1.6	-1.5	-0.5
Height	0.4	7.3	45.3	-6.7	-1.3	1.2	0.2	0.6	1.9	0.1	1.1	3.1	3.2	-1.8	-3.3
Waist Hip Ratio (WHR)	1.2	5.2	19.9	1.0	4.5	0.9	-0.3	3.5	2.6	-0.6	2.8	2.5	2.3	0.0	-1.5
Systolic Blood Pressure	1.0	4.9	11.1	-1.4	2.8	0.7	-1.0	2.4	3.1	-1.4	3.3	1.7	3.2	-1.2	-2.2
Smoking Status	0.6	1.5	8.3	-1.8	-0.9	-1.5	-0.8	-2.9	-0.7	-0.9	-0.8	-0.3	-0.7	-0.8	0.1
Allergy or Eczema	0.8	2.2	4.7	1.6	0.1	1.7	1.4	-0.7	-1.6	1.7	-1.6	-0.9	-1.7	2.2	1.5
Cardiovascular Disease	1.0	3.2	8.3	-2.6	0.9	-1.2	-1.8	0.2	2.1	-2.2	2.2	-0.2	1.9	-2.9	-0.2
Hypothyroidism (self reported)	0.1	0.2	1.3	0.3	1.0	1.2	0.3	0.3	0.2	0.3	0.1	0.1	-0.0	-0.1	-0.2
Respiratory disease	0.2	0.5	2.2	1.5	-0.0	0.5	0.5	0.7	0.0	0.5	-0.0	-1.2	-0.4	-0.0	0.8
Type 2 Diabetes (T2D) (2018)	0.1	0.2	1.1	0.1	0.1	-0.3	0.2	-0.3	0.2	0.2	0.3	-0.6	0.2	-0.8	1.0
Lung FEV1/FVC ratio	0.1	0.6	2.0	-0.0	1.4	1.0	0.9	0.8	0.1	0.5	0.0	-1.1	0.2	1.0	0.3
Lung FVC	2.6	13.1	29.2	-5.4	2.2	0.0	-3.8	1.0	4.0	-3.8	3.7	4.4	4.0	-3.2	-4.4
Neuroticism	0.6	1.5	4.2	-1.1	-0.0	-0.8	-0.9	1.1	1.8	-1.0	1.8	0.0	1.5	-2.1	-0.5
Chronotype (morning person)	0.4	0.9	2.5	-1.6	-1.0	0.2	-0.9	0.4	1.0	-0.8	0.9	0.3	0.9	-0.9	-1.5
Hair Pigment	0.0	0.8	4.2	0.6	1.3	0.4	-0.4	2.0	0.9	-0.5	0.9	0.5	0.7	-0.1	-0.9
Tanning	0.2	2.6	8.2	0.9	-2.9	-1.2	0.2	-1.3	-1.9	0.2	-1.8	-1.9	-2.0	0.3	2.0
Hand grip strength (left)	1.8	4.8	19.1	-0.7	-2.2	-0.8	0.8	-4.4	-2.6	1.0	-2.7	-1.4	-2.2	2.0	2.5
Number of treatments/medications taken	0.5	1.0	5.0	0.1	2.2	0.8	0.3	2.0	0.8	0.3	0.9	-0.0	0.3	-0.6	0.1
Average weekly spirits intake	2.6	3.2	10.3	-1.4	-1.5	-1.6	-0.9	-3.2	-1.6	-0.8	-1.7	-2.1	-1.6	-1.3	2.4
Sensitivity / hurt feelings	0.6	1.0	2.2	-1.5	1.0	-1.2	-0.9	-0.8	1.0	-1.1	1.0	-0.4	0.8	-1.4	0.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	3.2	0.4	1.8	0.5	0.5	1.1	-0.5	0.4	-0.5	-0.6	-0.2	-0.3	0.1
Hearing difficulty/problems: Yes	1.0	1.5	5.1	0.6	2.3	1.6	1.3	1.8	0.3	1.3	0.4	1.1	0.3	1.2	-0.7
Relative age of first facial hair	0.8	1.7	5.2	-2.3	-1.1	-0.8	-1.5	-0.7	1.2	-1.3	1.1	1.1	1.2	-1.0	-1.6
Other serious medical condition/disability diagnosed by doctor	1.8	2.4	5.8	1.7	1.1	1.7	2.4	-0.1	-0.9	2.1	-1.0	-1.8	-1.3	1.4	1.7
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.2	-0.4	-0.6	-1.5	-1.2	-1.2	-0.4	-1.0	-0.4	-0.4	-0.3	-0.3	0.3
Ever had hysterectomy (womb removed)	0.6	0.6	2.4	-0.2	0.1	-0.6	-1.0	1.0	0.4	-1.2	0.4	-1.0	0.4	-1.5	0.0
Systolic blood pressure, automated reading	1.2	3.6	8.0	-1.6	2.5	0.3	-0.8	1.6	2.6	-1.2	2.8	1.6	2.6	-1.0	-2.1
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	6.2	0.1	2.5	0.9	-0.7	0.5	0.9	-0.5	1.0	1.7	0.9	0.5	-1.1
Angina	0.4	0.5	1.2	-1.0	-1.1	-1.0	-0.6	-0.1	0.7	-0.7	0.7	-0.0	0.6	-1.1	0.0
Medication for hormone replacement therapy	1.3	1.5	4.8	2.2	-0.9	-0.4	0.7	-0.6	-1.4	0.7	-1.3	-0.7	-1.3	1.8	1.3
Vitamin and mineral supplements	0.1	0.1	0.3	-0.3	0.3	0.1	0.4	-0.2	0.4	0.2	0.5	0.2	0.6	0.3	0.5
Supplements: Zinc	0.8	0.9	3.1	0.2	1.4	1.1	-0.4	1.1	0.5	-0.2	0.6	1.8	0.8	0.1	-1.3
Medication: Co-codamol	0.8	0.9	3.4	0.2	0.6	-0.2	0.6	-0.6	-1.0	0.4	-1.0	-1.8	-1.3	-0.2	1.5
Medication: Metformin	0.6	0.9	2.3	1.4	1.1	0.7	1.2	0.2	-0.8	1.2	-0.6	-0.6	-0.7	0.3	1.5
Diabetes (father)	0.7	0.8	3.7	1.9	1.0	0.5	0.1	1.8	0.6	0.2	0.7	0.7	0.7	-0.1	0.0
Diabetes (mother)	0.4	0.5	1.1	-1.0	0.3	-0.6	-0.8	-0.5	0.6	-0.6	0.7	0.6	0.9	-0.7	-0.7
Severe depression (siblings)	0.6	0.7	3.8	-1.1	-2.0	-1.1	-0.8	-0.3	-0.4	-0.6	-0.5	-0.6	-0.2	-0.4	0.2
Pack years adult smoking proportion	0.4	0.6	2.0	0.6	-0.4	-0.8	-0.8	0.3	0.8	-1.1	0.9	-0.7	0.5	-1.4	0.1
Impedance of leg (right)	0.3	1.5	6.9	1.7	1.2	1.1	-0.2	1.3	0.5	-0.1	0.8	2.6	0.4	1.0	-1.4
Leg fat-free mass (left)	0.3	1.5	9.3	-3.1	0.3	1.4	1.0	0.1	0.8	0.8	0.4	-0.1	1.5	-1.6	-0.4
Trunk fat percentage	1.0	4.1	10.9	-1.9	2.4	2.5	-0.1	0.8	2.3	-0.2	2.3	3.3	2.5	-0.8	-2.3
Hand grip strength (right)	0.8	2.2	7.9	-1.7	-2.8	-1.7	-1.1	-2.7	-0.7	-1.0	-0.9	-0.6	-0.4	-0.4	0.8
Townsend deprivation index at recruitment	1.1	1.5	4.2	0.5	2.1	0.9	0.8	1.7	0.9	0.7	1.0	1.8	0.9	0.6	-1.7
Current tobacco smoking	2.8	4.6	11.0	-3.3	-1.0	-2.0	-2.6	-1.5	2.0	-2.8	1.8	1.2	1.9	-2.5	-1.8
Average weekly fortified wine intake	1.1	1.3	4.4	-0.1	1.0	2.1	1.5	-0.5	-0.8	1.6	-0.9	-0.3	-1.0	1.2	1.0
Maternal smoking around birth	0.2	0.3	1.0	1.0	-1.0	-0.8	0.4	-0.4	-0.3	0.3	-0.3	-0.4	-0.5	0.1	0.6
Fed-up feelings	0.4	0.8	3.0	0.6	1.5	1.7	1.0	1.3	-0.1	0.9	-0.1	-0.6	-0.1	-0.4	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.5	0.3	1.3	1.5	1.5	0.4	-0.8	1.6	-0.8	0.4	-0.8	1.5	-0.3
Relative age voice broke	0.3	0.4	1.0	0.0	-0.8	-0.5	0.5	-0.9	-0.6	0.5	-0.6	-1.0	-0.6	0.4	0.7
Taking other prescription medications	0.7	1.0	2.4	1.2	1.5	0.9	0.9	0.9	-0.6	0.9	-0.6	-1.3	-0.9	0.0	1.4
Age when periods started (menarche)	0.9	2.1	9.4	-1.8	-1.2	-3.1	-1.5	-2.5	0.1	-1.4	0.1	0.6	0.2	-0.1	-0.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.9	-0.4	-0.3	0.3	-0.6	1.7	0.9	-0.8	1.0	-0.0	1.1	-1.1	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.8	10.6	3.3	-0.2	-1.2	0.8	-1.0	-2.2	0.9	-1.9	-2.5	-2.3	1.9	2.7
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	3.2	-0.8	-0.1	0.1	-0.3	-1.8	-1.0	-0.1	-0.9	-0.2	-0.7	0.2	0.5
Qualifications: CSEs or equivalent	0.7	0.9	2.3	1.5	-0.6	-0.5	-0.9	1.3	-0.4	-0.9	-0.4	-1.4	-0.5	-1.2	0.5
Serious illness, injury or assault to yourself	0.9	1.1	9.3	0.4	3.1	1.0	0.8	0.3	-0.2	0.7	-0.2	0.1	-0.6	0.5	0.5
High blood pressure	0.5	1.4	3.4	-1.8	0.8	-0.5	-0.8	0.3	1.6	-1.2	1.6	-0.4	1.6	-1.7	0.0
Hayfever, allergic rhinitis or eczema	2.1	4.6	8.2	2.5	-0.3	1.6	2.3	-0.5	-2.5	2.5	-2.5	-1.8	-2.5	2.9	2.2
Multivitamins +/- minerals	0.1	0.1	0.3	0.3	0.1	-0.6	-0.3	-0.1	-0.1	-0.2	-0.2	-0.5	-0.2	0.2	-0.3
Stomach or abdominal pain in last month	1.2	1.5	9.0	-0.5	3.0	1.8	0.6	0.9	1.2	0.3	1.1	0.0	0.7	-0.7	-0.7
Supplements: Glucosamine	0.1	0.2	0.7	-0.3	-0.2	-0.6	-0.4	-0.8	0.3	-0.5	0.3	-0.1	0.2	-0.3	-0.3
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.5	1.4	0.3	1.2	1.5	-0.1	-0.7	1.4	-0.6	-0.8	-1.1	1.6	1.1
Medication: Atenolol	0.2	0.2	0.8	-0.5	0.1	-0.3	0.0	0.3	0.1	-0.3	0.1	-0.7	0.1	-0.7	0.9
Medication: Levothyroxine sodium	0.3	0.6	1.8	1.3	1.0	1.3	0.7	1.0	0.2	0.7	0.2	-0.1	-0.2	0.7	0.1
Sitting height	0.4	2.7	17.9	-4.2	-2.2	-1.3	-0.7	-1.1	0.6	-0.7	0.1	1.0	1.4	-1.3	-1.1
Chronic bronchitis/emphysema (father)	0.9	1.1	2.4	1.4	0.0	0.2	1.4	0.3	-1.3	1.5	-1.2	0.2	-1.1	1.4	0.5
High blood pressure (mother)	0.3	0.5	1.1	-0.8	0.9	0.8	-0.2	-0.0	0.8	-0.2	0.9	-0.0	0.8	-1.1	-0.2
Body mass index (BMI)	0.3	1.2	5.2	-0.5	2.3	1.9	0.6	0.7	1.0	0.4	1.0	0.2	1.0	-1.3	-0.2
Impedance of leg (left)	0.2	1.2	7.1	1.2	0.4	0.2	-0.8	0.6	0.6	-0.6	0.8	2.7	0.4	1.0	-1.3
Leg predicted mass (left)	0.3	1.5	9.1	-3.0	0.3	1.4	1.1	-0.1	0.7	0.9	0.3	-0.2	1.3	-1.5	-0.3
Trunk fat mass	0.8	3.6	7.8	-2.2	2.0	2.5	0.2	1.0	2.1	0.1	1.9	2.8	2.4	-1.2	-2.1
Waist circumference	0.7	2.5	8.4	-0.9	2.9	1.5	-0.0	1.2	1.9	-0.3	1.8	1.5	2.0	-1.6	-1.2
Number of incorrect matches in round	0.5	0.8	4.1	0.1	0.4	2.0	0.6	1.7	0.1	0.4	0.0	-0.9	0.0	-1.1	0.6
Past tobacco smoking	1.4	2.5	9.9	-0.1	1.4	1.0	0.3	3.1	2.2	0.0	2.2	1.2	2.0	0.3	-1.4
Alcohol usually taken with meals	0.5	0.7	1.5	-0.5	0.7	-0.2	-0.5	1.1	1.2	-0.7	1.1	0.2	1.1	-1.2	-0.9
Nervous feelings	0.9	1.7	6.6	-1.5	-1.8	-2.6	-1.3	-1.1	0.5	-1.2	0.4	-0.6	0.3	-1.6	0.7
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	3.6	1.0	0.1	0.3	1.1	-0.1	-1.8	1.2	-1.8	-1.9	-1.7	0.3	1.5
Hearing difficulty/problems with background noise	0.2	0.4	1.7	-0.9	1.3	-0.4	-0.1	0.0	0.3	-0.2	0.5	1.0	0.6	-0.2	-0.7
Hair/balding pattern: Pattern 2	0.8	1.0	2.0	-0.1	1.4	1.2	0.1	0.6	1.3	-0.1	1.4	0.9	1.2	-0.8	-1.2
Had menopause	0.1	0.2	1.1	-1.1	-0.5	-0.6	-0.0	-0.1	0.1	-0.2	0.1	-0.2	-0.0	0.1	0.2
Had other major operations	1.6	1.9	7.4	-0.9	1.6	-0.7	-1.6	-0.2	1.3	-1.8	1.3	0.3	1.2	-2.7	-1.0
Forced vital capacity (FVC)	1.4	5.3	27.0	-5.2	0.4	-0.1	-2.0	-0.9	1.8	-2.0	1.3	2.6	2.3	-2.0	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.3	10.9	3.3	-0.2	-0.7	1.0	-0.8	-1.9	1.2	-1.7	-2.3	-2.2	2.0	2.1
Ever unenthusiastic/disinterested for a whole week	2.9	3.6	10.0	-3.2	-0.7	-2.9	-2.9	-1.3	-0.0	-2.8	-0.1	-0.8	-0.0	-2.4	0.1
Qualifications: None of the above	2.4	5.1	13.5	3.7	0.3	1.7	2.8	1.8	-2.2	2.8	-2.0	-2.4	-2.2	1.1	2.2
Financial difficulties in last 2 years	0.3	0.4	3.6	0.5	1.9	-0.2	0.1	-0.4	0.4	0.0	0.3	-0.6	-0.0	-0.1	0.2
Mouth/teeth dental problems	1.3	2.0	9.8	-0.8	-3.1	-2.5	-0.8	-2.1	-0.4	-0.8	-0.5	-0.7	-0.5	-0.1	0.2
Heart attack	0.6	0.7	1.4	1.0	-0.5	1.0	0.5	0.6	-1.0	0.7	-1.0	-1.2	-0.9	-0.3	1.1
Allergy	2.5	5.7	9.0	-2.5	-0.1	-1.7	-2.3	0.9	2.6	-2.6	2.7	2.4	3.0	-2.9	-3.0
Pain all over the body in last month	0.1	0.2	0.5	0.7	0.6	0.3	0.1	0.1	0.5	0.3	0.5	0.0	0.4	-0.4	0.3
Diabetes (self-reported)	0.5	0.8	2.6	1.5	0.4	-0.0	0.9	0.1	-0.6	0.9	-0.5	-1.1	-0.7	0.2	1.6
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	5.8	1.9	0.1	2.4	2.1	0.7	-0.4	2.2	-0.4	-0.6	-0.7	1.4	0.6
Medication: Ramipril	1.2	1.6	5.0	-1.5	0.6	-0.3	-1.4	0.3	1.3	-1.7	1.4	0.5	1.3	-2.2	-0.6
Medication: Simvastatin	0.2	0.3	1.0	-0.3	-0.1	-0.5	-0.2	-0.9	-0.2	-0.2	-0.1	-0.4	-0.3	-0.7	1.0
Fluid intelligence score	3.3	6.9	13.5	-3.7	-0.7	-1.8	-3.3	0.2	2.8	-3.2	2.5	3.4	3.0	-1.6	-2.9
Illnesses of siblings	1.3	1.8	3.8	0.1	-1.5	-0.3	0.7	-1.6	-1.9	0.7	-2.0	-1.7	-1.9	0.5	1.5
Neuroticism score	0.7	1.5	3.1	-1.6	0.5	-0.9	-1.1	0.7	1.6	-1.1	1.6	0.1	1.4	-1.8	-0.7
Weight	0.4	2.1	6.1	-2.5	1.4	2.0	0.7	0.5	1.4	0.5	1.0	1.1	1.8	-1.7	-1.1
Impedance of arm (right)	0.9	4.3	17.6	-2.2	-0.5	-0.7	-1.8	-0.3	1.9	-1.6	2.0	4.2	2.2	0.1	-3.3
Arm fat percentage (right)	0.7	2.7	6.1	-1.3	2.5	2.3	0.1	1.1	1.7	-0.0	1.7	2.2	1.9	-1.1	-1.8
Trunk fat-free mass	0.2	1.1	3.8	-1.9	-0.4	0.7	1.1	0.3	-0.4	0.9	-0.9	-1.6	0.3	-1.6	0.7
Hip circumference	0.3	1.5	7.2	-2.7	0.6	0.7	-0.3	-1.0	1.0	-0.5	0.7	0.9	1.3	-1.9	-0.7
Time employed in main current job	0.1	0.2	0.6	0.4	0.1	0.8	0.4	0.7	-0.3	0.6	-0.3	0.3	-0.4	-0.1	0.1
Alcohol intake versus 10 years previously	1.7	2.5	11.5	0.2	3.4	1.8	0.4	2.3	1.3	0.2	1.4	1.1	1.5	-0.9	-1.5
Father’s age at death	1.0	1.4	3.8	0.1	1.9	1.0	0.3	0.5	1.4	0.1	1.5	1.9	1.5	0.1	-1.1
Worrier / anxious feelings	0.9	1.6	4.3	-1.4	-1.5	-1.7	-1.6	0.7	0.9	-1.5	0.9	-0.5	0.9	-2.1	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	2.9	-1.7	0.9	-0.5	-1.0	0.5	1.1	-1.0	1.1	1.1	1.2	-1.0	-1.3
Falls in the last year	0.1	0.2	1.5	-0.2	0.2	0.3	0.1	-0.2	-0.0	-0.1	-0.1	-0.5	0.1	-1.2	0.4
Hair/balding pattern: Pattern 3	0.3	0.5	2.1	0.7	-1.1	-0.6	-0.2	1.4	-0.2	-0.1	-0.2	-0.8	-0.1	-0.3	0.8
Number of live births	1.6	2.2	4.2	-1.4	0.0	-1.5	-1.6	1.0	2.0	-1.7	2.0	1.0	1.9	-1.4	-1.3
Forced expiratory volume in 1-second (FEV1)	1.2	4.2	19.0	-4.4	1.0	0.1	-1.8	0.0	1.8	-1.9	1.4	2.1	2.3	-1.7	-2.4
Pulse rate	0.3	0.6	1.6	0.5	1.2	0.4	0.7	-0.4	-0.6	0.8	-0.5	0.4	-0.5	1.3	0.9
Happiness	0.7	0.9	3.2	1.4	1.8	0.7	0.6	1.6	-0.3	0.4	-0.3	-1.1	-0.4	-0.5	0.1
Noisy workplace	2.1	2.6	7.1	1.4	2.5	2.7	2.5	0.2	-0.5	2.5	-0.4	0.7	-0.7	1.3	-0.1
Qualifications: A levels/AS levels or equivalent	1.0	2.3	4.6	-2.1	-0.7	-1.0	-1.7	0.2	1.5	-1.6	1.4	2.2	1.8	-0.6	-2.0
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	5.3	-1.3	-1.7	-2.3	-1.7	-1.1	-0.4	-1.4	-0.5	0.2	-0.4	-0.4	-0.3
Mouth/teeth dental problems: Dentures	0.5	0.8	3.7	0.8	1.9	1.0	1.2	0.8	-0.2	1.0	-0.1	-0.0	-0.5	0.8	0.7
Asthma	0.1	0.2	0.7	0.4	0.7	-0.3	-0.5	-0.4	0.5	-0.5	0.4	-0.8	-0.0	-0.1	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	3.1	-0.7	1.8	1.1	0.4	0.0	1.1	0.5	1.0	1.1	0.8	1.1	-0.6
Medication: Cholesterol lowering	0.5	0.9	2.7	-0.5	-1.2	-1.1	-0.5	-1.6	-0.6	-0.4	-0.6	-0.5	-0.9	-0.4	1.5
Depression (self-reported)	0.1	0.1	0.5	-0.1	0.7	0.1	0.2	-0.4	0.1	0.1	0.0	0.2	-0.1	0.5	-0.4
Medication: Lansoprazole	0.9	1.0	4.6	1.3	2.1	1.6	0.6	1.2	0.5	0.5	0.6	0.3	0.5	0.2	-0.4
Prospective memory result	0.4	0.4	2.2	-0.2	1.5	1.3	0.3	0.4	0.2	0.3	0.4	0.3	0.6	-0.6	-0.3
Lung cancer (father)	0.1	0.1	0.3	-0.5	-0.5	-0.0	-0.4	0.1	-0.4	-0.3	-0.3	0.4	-0.1	-0.2	0.1
Illnesses of mother	0.2	0.2	0.9	0.4	0.5	-0.1	0.7	-0.4	0.0	0.6	0.0	0.1	0.1	0.9	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.6	16.9	-4.1	2.1	1.0	-1.4	0.7	2.1	-1.5	1.7	2.4	2.5	-1.4	-2.7
Pulse wave Arterial Stiffness index	1.7	2.0	4.3	1.3	-0.1	0.4	1.5	0.4	-2.1	1.6	-2.0	-1.3	-1.8	1.1	1.7
Impedance of arm (left)	0.8	3.7	13.9	-2.2	-0.8	-0.8	-1.7	-0.7	1.7	-1.6	1.9	3.7	2.0	0.1	-2.8
Arm fat mass (right)	0.6	2.3	5.6	-1.5	2.3	2.4	0.5	0.9	1.5	0.4	1.4	1.6	1.8	-1.2	-1.3
Trunk predicted mass	0.2	1.0	4.0	-2.0	-0.4	0.8	1.1	0.3	-0.3	0.9	-0.8	-1.4	0.4	-1.5	0.6
Standing height	0.4	3.6	23.9	-4.9	-1.9	0.3	0.0	-0.5	1.0	0.0	0.4	2.0	2.1	-1.4	-1.9
Length of working week for main job	0.3	0.4	1.5	0.2	-0.7	-0.4	0.3	-0.4	-0.6	0.2	-0.7	-1.2	-0.6	0.3	0.9
Exposure to tobacco smoke at home	0.4	0.4	1.8	-0.6	1.2	0.8	-0.1	0.1	0.5	-0.1	0.4	-0.4	0.3	-1.3	-0.2
Breastfed as a baby	0.4	0.4	2.5	1.6	-0.7	-0.2	0.4	0.1	-0.4	0.4	-0.3	-0.1	-0.3	1.2	0.3
Tense / ‘highly strung’	0.3	0.5	1.7	-1.3	-0.0	0.3	-0.3	0.6	0.8	-0.2	0.8	-0.2	0.7	-1.2	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	5.0	-1.6	1.9	0.1	-1.4	1.0	2.2	-1.6	2.2	1.3	2.2	-1.5	-2.1
Hair/balding pattern: Pattern 4	1.0	2.4	9.3	0.8	0.5	0.6	2.0	-1.3	-1.6	1.9	-1.6	-0.3	-1.6	3.1	1.3
Birth weight of first child	2.5	4.6	8.4	-2.9	0.6	-0.2	-2.3	1.1	2.5	-2.3	2.5	1.9	2.9	-2.4	-2.1
Peak expiratory flow (PEF)	0.2	0.5	2.4	-1.5	0.2	0.6	0.1	0.2	0.4	0.1	0.1	0.8	0.6	0.8	-1.3
Pulse wave reflection index	0.9	1.1	2.9	1.0	-0.5	-0.5	0.3	-0.4	-1.5	0.4	-1.4	-1.7	-1.4	0.5	1.5
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.8	0.9	0.4	0.2	1.7	0.8	-0.4	1.5	-0.4	-1.4	-0.8	1.1	1.3
Loud music exposure frequency	0.7	0.8	2.8	0.4	-0.9	-0.5	0.5	-1.7	-0.9	0.3	-0.9	-1.0	-0.8	0.4	1.2
Qualifications: O levels/GCSEs or equivalent	2.1	3.3	6.8	-1.6	-0.6	-1.5	-2.5	-0.3	1.8	-2.6	1.7	2.0	2.1	-1.4	-2.1
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.2	0.2	1.8	1.2	0.1	1.4	0.3	-0.0	0.3	-0.8	0.6	-1.4	0.4
Blood clot in the leg (DVT)	1.3	1.7	4.1	0.2	0.3	1.0	1.2	-1.3	-1.6	1.5	-1.7	-1.0	-2.0	1.1	1.4
Medication: Paracetamol	0.3	0.5	1.1	-0.6	0.6	0.1	-0.1	-0.8	1.0	-0.1	0.9	1.1	0.8	-0.1	-0.7
Headache pain in last month	0.8	1.4	2.8	-0.9	0.5	0.1	-0.8	1.6	1.5	-0.8	1.6	1.2	1.3	-0.9	-1.7
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.8	0.7	-0.5	0.0	0.6	-0.1	-0.3	0.6	-0.4	0.2	-0.1	0.9	-0.5
Glaucoma (self-reported)	0.4	0.4	1.9	-0.9	-0.4	0.4	0.2	1.4	0.4	0.2	0.3	0.7	0.3	-0.6	-0.9
Gout (self-reported)	0.6	0.8	3.3	-0.5	1.1	1.8	1.5	0.3	-0.2	1.2	-0.2	0.4	-0.1	0.9	0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.8	1.2	0.9	1.4	0.8	0.3	-0.4	0.8	-0.4	-0.1	-0.5	0.6	0.1
Medication: Amlodipine	3.1	4.4	10.7	-0.2	3.3	2.6	0.4	2.7	2.6	0.0	2.6	1.5	2.3	-1.5	-2.0
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.2	0.8	1.0	0.3	-0.0	0.1	-0.2	-0.2	-0.1	-1.1	-0.4	-0.1	0.8
Birth weight	0.6	1.4	4.0	-0.3	0.7	1.0	1.8	-0.6	-1.0	1.9	-1.1	-0.6	-1.0	2.0	0.6
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.7	1.4	-0.7	-0.2	0.9	-0.5	-1.3	0.9	-1.2	-1.4	-1.6	0.6	1.6
High blood pressure (siblings)	0.2	0.3	0.6	0.1	0.8	-0.2	-0.5	0.5	0.7	-0.4	0.7	0.0	0.5	-0.5	0.3
Forced vital capacity (FVC), Best measure	1.6	6.0	23.3	-4.8	1.6	1.0	-1.4	0.2	2.3	-1.5	1.9	3.2	2.8	-1.6	-3.2
Body fat percentage	0.9	3.6	8.1	-1.1	2.7	2.8	0.3	1.2	2.0	0.2	2.1	2.8	2.1	-0.8	-1.9
Leg fat percentage (right)	1.0	3.5	13.2	0.8	3.6	3.5	1.1	1.9	1.3	1.0	1.4	1.9	1.3	-0.2	-1.1
Arm fat-free mass (right)	0.2	0.9	2.4	-1.5	0.4	1.3	1.2	0.6	-0.0	1.0	-0.4	-1.1	0.4	-1.3	0.7
Exposure to tobacco smoke outside home	0.6	0.7	2.4	1.5	1.0	1.2	0.6	0.8	-0.6	0.7	-0.6	-1.1	-0.5	0.3	0.9
Comparative body size at age 10	0.6	1.7	8.1	-0.3	2.4	2.8	1.3	0.9	1.0	0.9	1.0	1.0	0.7	0.5	-0.2
Number of full brothers	0.1	0.2	0.5	0.1	0.6	-0.5	-0.5	-0.1	0.3	-0.7	0.4	-0.1	0.2	-0.7	-0.3
Worry too long after embarrassment	1.3	2.2	4.6	-1.4	-2.0	-2.1	-1.8	-0.5	1.1	-2.0	1.1	-0.2	1.4	-2.1	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.8	0.1	1.2	1.2	-0.4	1.7	1.2	-0.3	1.2	1.0	1.0	-0.2	-1.0
Wheeze or whistling in the chest in last year	0.1	0.2	0.8	0.2	-0.8	-0.5	-0.1	0.2	-0.2	-0.1	-0.3	-0.9	-0.4	-0.1	0.4
Number of children fathered	2.3	2.6	7.1	0.4	-2.0	-1.1	0.3	-2.1	-1.6	0.2	-1.7	-2.5	-1.7	-0.3	2.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	1.1	0.6	0.3	-0.2	-0.4	1.0	0.5	-0.4	0.6	0.1	0.5	-0.5	-0.0
Age at first live birth	0.9	1.6	4.6	-0.7	-2.1	-1.6	0.3	-2.0	-1.1	0.5	-1.2	-0.5	-1.2	1.0	1.3
Pulse wave peak to peak time	2.2	2.6	5.3	-1.7	0.1	-0.4	-1.6	-0.2	2.3	-1.7	2.2	1.5	2.1	-1.4	-1.9
Health satisfaction	0.5	0.6	3.3	-0.1	1.8	0.7	0.1	1.1	0.6	-0.2	0.6	0.1	0.6	-1.0	0.0
Shortness of breath walking on level ground	1.7	2.1	4.2	2.0	0.5	1.0	1.9	0.0	-1.7	1.8	-1.6	-0.9	-1.6	1.7	1.0
Qualifications: College or University degree	1.1	3.3	6.4	-2.1	1.1	-0.5	-1.2	0.6	2.5	-1.4	2.4	2.5	2.5	-0.7	-2.4
Eye problems/disorders: None of the above	0.8	0.9	1.6	0.6	-0.1	0.4	1.0	-1.3	-1.0	0.7	-1.1	-1.2	-1.2	1.1	1.1
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.2	0.2	1.1	0.5	0.0	0.5	0.9	-0.2	1.0	0.7	0.9	-0.2	-1.0
Emphysema/chronic bronchitis	2.9	3.3	8.0	1.3	-1.4	-0.7	1.1	-1.7	-2.2	1.2	-2.1	-2.3	-2.5	1.1	2.8
Medication for pain relief, constipation, heartburn	0.3	0.6	2.1	0.1	-0.5	-0.5	-1.0	0.6	0.5	-1.0	0.5	0.8	0.7	-0.6	-1.5
Neck or shoulder pain in last month	0.5	0.8	2.6	-0.5	1.6	1.0	0.3	0.6	1.3	0.1	1.3	0.2	0.9	-0.8	-0.5
Medication: Blood pressure	0.2	0.4	1.6	-0.9	0.7	0.1	-0.3	0.5	0.7	-0.4	0.8	-0.3	0.6	-1.2	0.5
Angina (self-reported)	0.4	0.5	1.5	-1.0	-1.2	-0.9	-0.5	-0.2	0.7	-0.6	0.6	0.0	0.5	-0.8	0.1
Migraine (self-reported)	4.8	6.0	9.2	-3.0	0.3	-1.0	-2.6	1.4	2.9	-2.4	2.8	2.5	2.8	-2.8	-2.9
Medication: Ibuprofen	0.6	0.7	2.7	-0.6	1.6	1.5	0.9	0.1	0.7	0.8	0.7	0.5	0.4	1.0	0.1
Medication: Allopurinol	0.2	0.3	1.2	-0.7	0.2	1.1	0.8	0.4	-0.0	0.5	-0.1	0.0	0.0	0.1	0.4
Medication: Omeprazole	1.0	1.2	4.6	0.5	0.4	0.0	0.9	-0.2	-1.2	0.8	-1.2	-2.2	-1.2	0.3	2.0
Medication: Seretide 50 evohaler	0.5	0.6	1.4	0.4	1.2	0.9	0.6	-1.1	-0.1	0.7	-0.1	-0.6	-0.4	1.0	0.7
Mean time to correctly identify matches	0.2	0.4	1.1	0.8	-0.3	-1.0	-1.1	0.5	0.2	-0.8	0.2	0.6	0.1	-0.5	-0.6
Heart disease (mother)	0.7	0.9	3.1	-1.4	-1.8	-1.3	-1.0	-1.0	-0.3	-1.1	-0.4	-0.7	-0.2	-0.4	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	3.0	1.5	0.5	0.4	0.7	0.4	-1.0	0.7	-0.8	-1.7	-0.8	0.9	1.7
Whole body fat mass	0.7	3.0	8.2	-1.5	2.5	2.9	0.7	0.9	1.8	0.6	1.6	2.2	2.0	-1.1	-1.5
Leg fat mass (right)	0.7	2.8	10.2	-0.6	2.8	3.2	1.0	1.4	1.4	0.8	1.3	1.8	1.7	-0.9	-1.2
Arm predicted mass (right)	0.2	0.9	3.3	-1.8	0.3	1.1	0.9	0.6	0.2	0.7	-0.2	-1.0	0.7	-1.6	0.3
Pulse rate, automated reading	0.9	2.8	6.8	-1.7	-0.9	-2.2	-2.6	-0.3	1.4	-2.5	1.5	1.4	1.4	-1.7	-1.0
Alcohol intake frequency.	1.3	3.1	12.2	0.0	3.1	1.8	0.3	3.5	1.6	0.1	1.7	0.6	1.5	-1.2	-1.6
Comparative height size at age 10	0.6	3.1	17.0	-4.1	0.2	0.1	-0.4	1.1	1.6	-0.6	1.1	1.7	2.1	-2.0	-1.9
Number of full sisters	0.1	0.1	0.4	-0.6	-0.4	-0.6	-0.4	-0.5	-0.2	-0.4	-0.1	-0.2	-0.0	-0.1	0.3
Suffer from ‘nerves’	0.3	0.5	1.4	-0.0	0.5	-0.2	0.1	0.7	1.2	-0.2	1.2	-0.2	1.1	-0.4	0.6
Overall health rating	0.3	0.6	2.5	-0.2	1.6	0.1	0.4	1.1	0.7	0.0	0.7	-0.9	0.2	-0.8	0.8
Chest pain or discomfort	0.6	0.9	2.0	1.1	-0.7	0.5	1.0	0.6	-0.9	0.9	-0.9	-1.4	-0.9	0.7	1.0
Had major operations	0.2	0.3	1.2	0.3	-0.5	-0.3	-0.2	-1.0	-0.2	0.0	-0.2	0.4	-0.3	1.1	0.4
Age at last live birth	0.5	0.7	2.1	-1.4	-1.1	-1.4	-0.9	-1.3	0.1	-0.7	-0.0	0.7	0.1	-0.2	-0.4
Family relationship satisfaction	1.1	1.4	4.5	2.1	-0.2	0.6	1.1	1.0	-0.8	1.2	-0.8	-2.0	-0.8	-0.7	1.3
Leg pain on walking	0.3	0.4	1.3	-0.6	1.1	0.7	0.1	0.5	0.0	-0.2	-0.0	-0.8	0.3	-1.1	0.4
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	4.3	-0.6	2.1	1.1	0.5	0.2	1.8	0.2	1.8	1.9	1.2	1.1	-1.2
Commuting to job workplace: Car/motor vehicle	0.7	0.8	4.8	1.5	1.2	2.2	0.7	0.3	-0.3	0.6	-0.3	-0.3	-0.4	-0.3	0.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.6	0.9	-0.9	1.3	0.9	1.0	-0.0	0.8	0.1	0.3	0.3	0.2	-0.1
Medication: Aspirin	0.7	1.0	2.4	1.2	0.2	0.9	1.1	1.2	-0.7	1.0	-0.6	-1.6	-0.8	-0.1	1.3
Supplements: Vitamin C	1.8	2.2	3.8	1.2	-1.9	-0.7	0.4	-1.2	-1.9	0.7	-1.9	-1.9	-1.9	0.2	1.9
Knee pain experienced in last month	0.2	0.4	1.6	-0.3	0.2	1.3	0.5	0.4	0.1	0.3	-0.0	-1.0	-0.1	-1.0	0.3
Hypertension (Self-reported)	0.7	2.0	4.4	-2.1	0.8	-0.9	-1.2	0.5	1.8	-1.6	1.9	-0.1	1.7	-2.0	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	5.7	0.1	2.4	1.9	1.3	0.7	-0.2	1.2	-0.1	-0.3	-0.5	1.0	0.5
Illnesses of father: Heart disease	1.1	1.5	3.7	-0.4	0.4	1.0	1.5	-1.0	-1.3	1.5	-1.3	-0.4	-1.4	1.9	1.2
Illnesses of siblings: Diabetes	1.8	2.3	4.8	0.2	1.5	0.3	-0.9	1.2	2.1	-1.0	2.2	2.0	2.1	-0.5	-1.9
Smoking status: Previous	3.1	4.6	10.5	1.9	-0.6	0.2	1.5	-2.6	-3.2	1.7	-3.1	-1.8	-3.0	1.3	2.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.7	-1.6	-1.5	0.5	0.7	-0.7	-0.7	0.6	-1.0	-0.4	-0.1	0.3	0.0
Whole body fat-free mass	0.2	1.2	6.9	-2.6	-0.3	0.8	1.0	0.2	0.2	0.7	-0.3	-1.0	0.8	-1.7	0.2
Leg fat-free mass (right)	0.3	1.5	11.7	-3.4	-0.2	0.7	0.6	-0.4	0.7	0.5	0.3	-0.3	1.3	-1.6	-0.3
Arm fat percentage (left)	0.6	2.5	5.4	-1.2	2.3	2.2	0.1	0.9	1.7	-0.1	1.7	2.1	1.8	-1.0	-1.6
Average weekly red wine intake	0.7	1.0	2.7	-1.4	-1.0	-1.3	-1.3	-1.6	0.5	-1.3	0.3	0.2	0.4	-0.9	-0.7
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	-0.7	0.7	-0.4	-0.6	-0.7	0.3	-0.6	0.2	0.5	0.3	-0.5	-0.2
Mood swings	0.9	1.6	4.3	-1.1	1.1	0.6	-0.7	1.7	1.3	-0.7	1.3	0.5	1.4	-2.1	-1.5
Loneliness, isolation	0.8	1.1	2.7	0.5	1.4	1.0	1.3	0.2	-0.6	1.2	-0.7	-1.6	-0.9	0.8	1.5
Long-standing illness, disability or infirmity	1.2	1.8	5.6	0.8	2.1	1.8	2.4	0.2	-0.3	2.3	-0.2	-0.3	-0.7	1.1	0.7
Ever had bowel cancer screening	0.6	0.7	2.1	-1.4	1.5	0.6	-0.6	1.0	0.3	-0.8	0.2	0.9	0.4	-0.1	-0.9
Diabetes diagnosed by doctor	0.2	0.4	1.8	1.1	0.5	-0.2	0.5	0.0	-0.2	0.6	-0.0	-0.7	-0.3	-0.1	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	3.1	-0.5	1.8	0.4	0.5	-0.8	-0.0	0.3	-0.0	-0.8	-0.2	0.2	0.6
Friendships satisfaction	0.3	0.4	1.8	1.4	0.6	0.3	0.3	0.9	-0.4	0.4	-0.3	-0.9	-0.2	-0.8	0.4
Qualifications: nursing, teaching	2.2	3.4	9.4	-3.1	-0.3	-1.2	-1.9	-2.1	1.6	-1.8	1.4	2.0	1.8	-1.3	-2.1
Commuting to job workplace: Walk	0.7	0.8	2.3	-1.5	-1.5	-1.4	-0.6	-1.1	-0.2	-0.7	-0.2	-0.4	0.0	-0.2	0.6
Eye problems/disorders: Cataract	0.3	0.3	1.0	-0.6	1.0	0.7	-0.1	0.6	0.5	-0.0	0.6	0.6	0.7	-0.4	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.6	-1.6	1.9	1.4	-1.0	-0.3	1.0	-0.8	0.9	1.2	1.0	-1.2	-1.1
Medication for cholesterol	0.2	0.3	1.0	-0.9	-0.0	0.6	-0.0	-0.3	0.3	0.1	0.1	1.0	0.2	0.3	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.7	-1.0	-1.6	-1.6	-0.5	-0.6	0.5	-0.5	0.4	-0.1	0.4	-0.3	-0.0
Back pain experienced in last month	0.4	0.6	1.6	-1.3	-0.0	-1.0	-0.5	0.1	0.5	-0.7	0.3	-1.0	-0.1	-1.3	0.7
Mineral and other dietary supplements	0.7	1.0	1.9	0.8	0.2	0.7	1.4	-0.4	-1.1	1.3	-1.1	-1.1	-1.1	0.6	1.4
Breast cancer (self-reported)	0.8	1.0	3.4	-1.0	0.7	0.1	-1.1	0.8	0.9	-1.2	0.9	0.2	0.9	-1.8	-0.8
Asthma (self-reported)	0.2	0.4	1.1	0.3	0.8	-0.2	-0.6	0.1	1.0	-0.6	1.0	-0.3	0.6	-0.3	-0.0
Osteoporosis (self-reported)	0.5	0.7	1.4	-0.5	-0.2	0.9	0.3	-1.0	-1.1	0.3	-1.2	-1.1	-1.0	-0.4	1.0
Osteoarthritis (self-reported)	0.4	0.6	2.3	0.5	1.5	0.6	1.2	-0.5	0.1	1.0	0.2	0.4	-0.1	1.0	0.3
Medication: Aspirin	1.0	1.3	2.6	1.3	0.4	1.1	1.4	1.6	-0.7	1.4	-0.6	-1.6	-0.8	0.1	1.4
Medication: Gliclazide	2.8	3.2	8.1	2.8	0.6	0.7	2.4	-0.3	-1.7	2.4	-1.6	-1.5	-2.0	1.6	1.9
Illnesses of father: None of the above (group 1)	0.6	0.7	2.3	-0.4	-0.2	-0.7	-1.4	-0.7	0.7	-1.5	0.7	-0.0	0.8	-1.0	-0.6
Smoking status: Current	3.5	5.5	12.5	-3.5	-1.3	-2.1	-2.9	-1.0	2.3	-3.1	2.1	1.3	2.2	-2.8	-2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.4	8.7	-2.5	2.6	1.5	-1.3	2.1	2.1	-1.5	2.0	2.3	2.5	-0.8	-3.0
Whole body water mass	0.2	1.1	5.7	-2.4	-0.3	0.8	1.0	0.2	0.1	0.8	-0.4	-1.1	0.7	-1.7	0.3
Leg predicted mass (right)	0.3	1.6	12.0	-3.5	-0.1	0.7	0.6	-0.3	0.8	0.4	0.4	-0.2	1.4	-1.7	-0.4
Arm fat mass (left)	0.6	2.3	5.7	-1.4	2.4	2.4	0.5	0.8	1.5	0.3	1.4	1.6	1.8	-1.3	-1.2
Number of self-reported non-cancer illnesses	0.8	1.3	5.8	0.6	2.4	1.4	1.6	0.5	0.4	1.4	0.4	-1.1	-0.3	0.5	1.1
Average weekly champagne plus white wine intake	0.5	0.7	2.4	0.0	0.8	1.1	-0.3	1.5	0.7	-0.4	0.7	0.9	0.9	0.3	-0.8
Miserableness	1.2	2.2	4.5	-0.8	2.1	-0.2	-0.7	1.1	2.1	-0.9	2.1	1.1	1.9	-0.7	-2.1
Guilty feelings	1.5	2.2	7.1	0.1	-2.7	-0.7	0.3	-1.5	-2.1	0.5	-2.2	-1.6	-1.8	0.0	1.2
Wears glasses or contact lenses	0.9	1.0	6.3	1.3	1.1	0.3	0.5	2.5	0.7	0.5	0.8	0.4	0.5	-0.0	-0.8
Ever taken oral contraceptive pill	0.6	0.7	1.6	0.1	1.3	0.0	-0.3	0.9	1.2	-0.4	1.2	0.2	1.2	-0.1	-1.1
Hearing aid user	1.8	2.0	7.0	1.7	1.3	2.6	1.4	2.3	-0.9	1.5	-0.8	-0.1	-0.8	1.0	0.1
Mother’s age at death	0.2	0.2	0.5	0.1	0.7	0.6	-0.2	0.5	-0.4	-0.2	-0.5	0.4	-0.3	0.6	-0.4
Financial situation satisfaction	0.4	0.5	2.1	-0.5	0.5	-1.0	-1.0	-0.9	-0.0	-0.9	-0.1	-0.6	-0.1	-1.4	0.2
Tinnitus: Yes, now most or all of the time	0.8	1.0	3.7	-0.5	-1.9	-0.7	0.3	-1.9	-0.6	0.2	-0.7	-1.0	-1.0	-0.1	1.0
Commuting to job workplace: Public transport	1.1	1.3	4.5	-0.7	-1.8	-2.1	-1.2	-0.5	-0.8	-1.1	-0.9	-1.4	-0.7	-0.4	0.8
Eye problems/disorders: Glaucoma	0.4	0.5	2.0	-1.4	-1.2	0.3	-0.1	0.5	0.2	0.0	0.0	0.7	0.3	-0.9	-1.0
Medication: Blood pressure	1.0	1.9	4.0	-1.3	0.8	-0.5	-1.3	1.3	1.7	-1.7	1.8	-0.0	1.7	-2.0	-0.8
Pain type(s) experienced in last month: Hip pain	1.9	2.3	6.3	0.9	0.6	1.5	2.5	-0.8	-1.2	2.4	-1.2	-1.1	-1.7	1.5	1.7
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.6	-0.7	-0.6	-0.6	-0.8	0.1	0.5	-0.8	0.6	0.6	0.6	-0.1	-0.7
High cholesterol (Self-reported)	0.9	1.6	5.7	0.9	-1.5	-0.7	0.2	-0.7	-1.1	0.2	-1.0	-1.9	-1.6	-0.5	2.4
Medication: Bendroflumethiazide	1.4	2.2	4.0	-0.9	1.4	0.2	-1.3	1.9	1.8	-1.3	2.0	0.9	1.9	-1.6	-1.5
Medication: Paracetamol	0.3	0.4	1.5	-1.2	0.5	-0.1	-0.1	-0.9	0.9	-0.1	0.8	0.7	0.6	-0.5	-0.4
Medication: Lisinopril	0.3	0.4	1.5	-0.2	-1.0	-1.2	-0.4	-1.2	0.2	-0.5	0.2	-0.3	0.1	-0.0	0.3
Medication: Atorvastatin	1.3	1.6	5.0	0.4	-1.6	-1.1	-0.3	-0.7	-1.3	-0.2	-1.4	-2.2	-1.6	-0.8	1.8
Illnesses of father: High blood pressure	0.8	1.0	4.0	0.2	0.7	1.4	2.0	0.5	0.1	1.8	0.1	-0.6	-0.3	0.6	1.1
Alcohol drinker status: Never	1.3	1.6	2.2	-1.2	0.5	-0.3	-1.3	1.4	1.5	-1.5	1.5	1.2	1.5	-1.2	-1.4
Ever smoked	1.9	3.4	14.1	-0.5	-2.0	-2.0	-1.2	-3.8	-1.9	-1.0	-1.9	-1.4	-1.8	-0.9	1.6
Basal metabolic rate	0.2	1.2	6.3	-2.5	0.4	1.4	1.0	0.4	0.5	0.8	0.1	-0.3	1.2	-1.7	-0.2
Leg fat percentage (left)	0.8	2.7	10.3	0.4	3.2	2.9	0.7	1.6	1.4	0.6	1.4	1.9	1.3	-0.4	-1.1
Arm fat-free mass (left)	0.2	1.1	2.6	-1.6	0.8	1.6	1.4	0.7	0.2	1.1	-0.3	-0.9	0.7	-1.4	0.5
Number of operations (self-reported)	0.8	1.2	3.3	0.3	1.4	0.2	-0.6	1.1	1.8	-0.7	1.8	0.7	1.4	-1.2	-0.6
Average weekly beer plus cider intake	0.5	0.8	2.0	-0.8	0.3	-1.4	-1.2	-0.1	0.8	-1.2	0.9	0.8	0.9	-0.7	-0.9
Irritability	0.4	0.6	4.4	0.3	2.1	0.7	0.3	1.5	0.3	0.4	0.4	0.2	0.0	-0.1	-0.3
Risk taking	0.4	0.6	2.7	0.0	-0.6	-0.5	0.5	-1.6	-0.7	0.6	-0.7	-0.5	-0.7	1.1	0.6
Ever had prostate specific antigen (PSA) test	1.8	2.1	3.7	1.9	-0.8	1.8	1.7	1.0	-1.4	1.8	-1.4	-1.3	-1.3	1.4	1.3
Fractured/broken bones in last 5 years	0.5	0.6	2.6	0.0	0.2	0.6	0.9	-1.6	-0.8	1.0	-0.7	-0.4	-0.7	0.8	0.2
Age started oral contraceptive pill	0.2	0.3	1.7	-1.3	-0.2	-0.9	-0.5	-0.7	-0.0	-0.4	-0.0	0.2	0.2	-0.3	-0.2
Diastolic blood pressure, automated reading	1.5	4.7	9.5	-2.8	2.9	-0.4	-1.4	0.3	2.9	-1.9	3.0	1.7	3.1	-1.1	-1.9
Ever depressed for a whole week	1.1	1.3	3.5	-1.8	-0.2	-1.4	-1.8	-0.0	0.3	-1.8	0.2	-0.7	0.2	-1.9	-0.0
Unable to work because of sickness or disability	0.4	0.5	1.3	0.6	-0.6	-0.5	0.5	-0.5	-0.8	0.5	-0.8	-0.9	-0.8	-0.4	1.1
Commuting to job workplace: Cycle	0.5	0.6	4.4	-0.5	-2.1	-0.8	0.5	-0.8	0.3	0.4	0.3	-0.1	0.4	0.4	0.5
Myopia	1.3	1.9	3.8	-0.7	1.9	0.3	-0.7	1.0	1.7	-1.0	1.8	1.4	1.9	-0.8	-1.9
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.8	1.3	-0.7	0.3	0.4	-0.5	-1.3	0.8	-1.3	0.6	-1.2	1.2	-0.4
Cholesterol lowering medication	0.9	1.3	5.1	0.6	-0.9	-1.0	-0.4	-0.2	-0.9	-0.4	-0.9	-2.3	-1.0	-1.7	1.7
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	5.1	1.1	0.2	0.5	1.5	-0.2	-1.8	1.5	-1.7	-2.3	-1.6	1.0	2.1
Pain experienced in last month	0.3	0.4	1.3	0.2	-0.3	0.1	0.0	-0.7	-1.1	0.2	-1.1	0.4	-0.7	1.0	0.4
Supplements: Calcium	0.8	0.9	2.1	-1.2	-1.0	-1.0	-1.5	0.5	0.6	-1.4	0.6	0.6	0.7	-0.8	-0.7
Basal cell carcinoma (self-reported)	0.9	1.0	1.9	0.9	0.9	1.1	1.4	-1.0	-1.1	1.4	-1.1	-0.7	-1.1	0.7	0.4
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.2	1.1	-0.4	1.0	0.6	0.7	-0.9	0.8	-0.9	-1.0	-0.9	-0.0	1.1
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	4.9	0.6	0.7	1.7	2.0	-1.4	-1.8	2.2	-1.9	-1.1	-2.2	1.5	1.5
Heart disease (siblings)	0.2	0.2	0.8	-0.4	-0.2	-0.5	-0.9	-0.1	0.3	-0.9	0.2	0.2	0.3	-0.3	-0.4
Alcohol drinker status: Previous	0.8	0.9	2.7	-0.2	0.8	0.1	0.1	0.4	1.2	0.1	1.2	1.6	1.3	0.6	-1.4
Pack years of smoking	0.6	0.8	3.0	0.7	-0.6	-0.9	-0.9	0.6	0.9	-1.2	1.0	-0.5	0.6	-1.7	0.1
Impedance of whole body	0.5	2.8	14.0	-0.9	-0.2	-0.2	-1.5	-0.0	1.6	-1.3	1.8	3.7	1.6	0.5	-2.5
Leg fat mass (left)	0.6	2.4	7.4	-0.9	2.5	2.7	0.7	1.2	1.5	0.5	1.4	1.7	1.7	-1.2	-1.2
Arm predicted mass (left)	0.2	1.2	4.4	-2.1	0.8	1.1	0.7	1.0	0.7	0.5	0.3	-0.4	1.2	-2.0	-0.1