TWAS hub - DLEU1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.167	0.0500	0.00030	0.097	NA	0.088	NA	0.096	4.8e-07	NA	1.7e-06	NA	5.7e-07
2	GTEx	Skin Sun Exposed Lower leg	0.113	0.0340	0.00029	0.120	NA	0.090	NA	0.103	3.8e-10	NA	6.9e-08	NA	7.1e-09
3	YFS	Blood	0.134	0.0195	0.00000	0.119	0.136	0.156	0.157	0.157	8.0e-37	3.0e-42	1.5e-48	8.3e-49	7.4e-49
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.127	0.0570	0.00600	0.041	0.015	0.022	NA	0.039	2.0e-03	4.3e-02	2.0e-02	NA	2.6e-03
5	TCGA	Testicular Germ Cell Tumors	0.322	0.1280	0.00210	-0.006	0.085	0.119	NA	0.073	5.7e-01	6.4e-04	5.6e-05	NA	1.4e-03
6	TCGA	Thyroid Carcinoma	0.115	0.0410	0.00023	0.059	0.032	0.045	NA	0.051	2.1e-06	3.9e-04	3.2e-05	NA	1.0e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Commuting to job workplace: Car/motor vehicle	11.8	13.5	22.6	3.8	4.1	3.8	2.7	2.2	4.7
Diabetes (father)	9.7	12.0	19.2	3.8	3.4	4.4	3.1	2.8	3.1
Leg fat percentage (right)	8.1	29.4	38.2	4.6	6.1	6.2	5.8	5.0	4.6
Leg fat percentage (left)	6.4	23.3	30.8	3.9	5.3	5.4	5.6	4.5	4.1
Noisy workplace	5.6	7.0	8.7	2.0	2.7	2.8	3.0	2.7	2.6
Family relationship satisfaction	4.8	5.9	8.3	2.8	2.4	2.9	1.7	2.0	2.5
Number of incorrect matches in round	4.7	7.8	13.2	3.6	3.0	2.3	0.3	3.0	3.2
Commuting to job workplace: Walk	4.7	5.1	7.1	-2.0	-2.5	-2.7	-2.1	-1.8	-2.4
Medication: Lansoprazole	4.6	5.3	10.3	1.2	2.4	2.5	3.2	2.1	1.8
Had other major operations	4.5	5.5	11.4	1.7	2.1	2.4	2.6	3.4	1.3
Body fat percentage	4.3	16.8	22.7	3.6	4.8	4.4	4.2	3.7	3.8
Leg fat mass (right)	4.3	16.8	22.9	4.0	4.8	4.2	3.6	3.7	4.3
Impedance of leg (right)	3.6	17.7	28.8	5.1	5.1	5.4	2.7	1.3	4.1
Leg fat mass (left)	3.6	13.9	18.0	3.6	4.2	3.7	3.3	3.5	3.9
Lupus	3.4	5.2	8.5	2.6	2.5	2.4	1.9	-0.6	2.9
Commuting to job workplace: Public transport	3.4	4.1	5.3	-1.5	-2.1	-2.3	-2.3	-1.5	-2.3
Peak expiratory flow (PEF)	3.3	7.6	22.1	-0.5	-1.3	-3.2	-4.7	-3.3	0.6
Hearing aid user	3.3	3.7	5.4	1.4	2.3	2.2	2.0	1.8	1.6
Financial difficulties in last 2 years	3.1	4.1	5.9	1.4	2.2	2.2	2.2	2.4	1.5
Current tobacco smoking	3.0	4.9	8.7	-2.9	-2.7	-2.5	-1.3	0.2	-2.4
Ever unenthusiastic/disinterested for a whole week	3.0	3.7	11.4	-1.0	-1.6	-2.2	-3.4	-0.5	-1.3
Smoking status: Current	3.0	4.8	8.3	-2.9	-2.7	-2.5	-1.3	0.1	-2.3
Hypothyroidism (self reported)	2.8	6.5	10.0	2.2	2.7	3.2	2.3	2.9	1.7
Trunk fat percentage	2.8	11.3	16.6	3.1	4.1	3.3	3.0	3.1	3.3
Mouth/teeth dental problems: Bleeding gums	2.8	3.7	5.0	1.7	2.0	2.2	2.0	1.8	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	2.8	3.7	6.7	2.6	2.4	2.0	0.9	0.6	2.1
Medication: Co-codamol	2.7	3.2	6.9	-2.0	-2.0	-1.5	-0.1	-2.6	-1.3
Whole body fat mass	2.7	11.1	16.0	3.5	4.0	3.1	2.6	2.9	3.7
Schizophrenia vs Biploar Disorder	2.6	3.4	6.6	1.9	2.6	1.8	1.0	1.2	2.1
High blood pressure	2.6	7.2	11.5	-3.4	-3.4	-2.8	-1.3	0.7	-3.2
Sitting height	2.6	18.4	62.6	-0.1	-2.8	-5.4	-7.9	-3.3	-0.5
Mouth/teeth dental problems	2.6	4.0	7.6	-1.1	-1.6	-2.0	-2.8	-2.7	-0.9
Hypertension (Self-reported)	2.6	7.1	12.3	-3.5	-3.3	-2.9	-1.3	0.7	-3.1
Diastolic blood pressure, automated reading	2.6	8.0	13.0	-3.3	-3.0	-2.8	-2.2	1.6	-3.6
Illness, injury, bereavement, stress in last 2 years	2.5	3.0	5.9	-1.4	-1.9	-1.8	-1.2	-2.4	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.5	3.0	4.5	-2.1	-1.4	-1.7	-0.9	-1.8	-2.1
Primary Biliary Cirrhosis	2.4	3.4	5.0	1.7	1.6	2.2	2.0	1.6	1.8
Chronic bronchitis/emphysema (father)	2.4	2.8	4.9	1.8	2.2	2.2	1.4	0.5	1.2
Arm fat percentage (right)	2.4	9.4	13.1	2.3	3.6	3.1	3.1	3.4	2.7
Medication: Paracetamol	2.4	4.1	6.5	1.8	2.3	2.0	1.3	2.5	1.9
Supplements: Vitamin C	2.4	2.9	6.0	2.4	1.8	1.6	0.2	0.4	2.3
Friendships satisfaction	2.4	2.9	6.8	2.6	2.2	1.6	0.0	0.3	1.7
Vascular/heart problems diagnosed by doctor	2.4	6.7	11.0	3.3	3.3	2.6	0.9	-0.9	3.1
Respiratory disease	2.3	5.2	9.4	3.1	2.1	2.4	0.8	2.3	2.3
Hand grip strength (right)	2.3	6.2	13.5	-0.1	-1.9	-2.8	-3.7	-3.4	-0.7
Impedance of leg (left)	2.3	11.1	19.3	4.0	3.9	4.4	2.5	0.5	3.2
Number of live births	2.3	3.3	6.0	-2.4	-1.7	-1.8	-0.3	-1.8	-2.1
Arm fat percentage (left)	2.3	9.0	12.0	2.1	3.5	3.1	3.4	3.2	2.6
Fractured/broken bones in last 5 years	2.3	3.0	5.2	-2.3	-2.1	-2.2	-1.4	-0.5	-1.1
Taking other prescription medications	2.2	3.5	5.7	1.5	2.1	2.1	2.4	1.4	1.6
Medication: Levothyroxine sodium	2.2	3.7	5.7	1.3	1.7	2.1	2.4	2.3	1.4
Hair/balding pattern: Pattern 4	2.2	5.4	8.1	-2.2	-2.7	-2.8	-2.5	-0.8	-2.3
Neuroticism (2016)	2.1	3.0	6.1	2.5	1.7	1.8	1.0	1.8	1.3
Cardiovascular Disease	2.1	7.0	12.1	-3.4	-3.5	-2.8	-1.2	0.7	-2.9
Trunk fat mass	2.1	9.2	13.6	3.4	3.7	2.5	1.7	2.7	3.6
Illnesses of mother	2.1	2.6	6.5	-1.5	-1.1	-1.8	-1.4	-2.5	-0.9
Body Mass Index (BMI) (2010)	2.0	2.8	4.9	1.8	2.2	1.6	1.2	1.4	1.6
Had menopause	2.0	2.5	3.8	-1.7	-1.8	-1.4	-0.3	-1.8	-1.9
Hypothyroidism/myxoedema (self-reported)	2.0	3.9	5.6	1.7	2.0	2.4	2.1	2.1	1.3
Hand grip strength (left)	1.9	4.9	10.3	-0.4	-1.5	-2.6	-3.0	-3.2	-0.9
Standing height	1.9	18.5	65.8	3.2	-0.5	-3.8	-8.1	-4.0	2.1
Mouth/teeth dental problems: Mouth ulcers	1.9	3.0	5.2	2.3	1.9	1.8	1.0	1.5	1.5
Alcohol drinker status: Never	1.9	2.2	3.7	-1.1	-1.9	-1.7	-1.7	-1.2	-1.1
Ever depressed for a whole week	1.9	2.4	9.1	-0.3	-0.7	-1.6	-3.0	-1.4	-0.5
Blood Eosinophil Count	1.8	13.7	35.6	1.0	1.6	3.9	6.0	5.2	0.9
Eye problems/disorders: Diabetes related eye disease	1.8	2.0	4.5	0.3	1.3	1.3	1.4	2.1	1.5
Body mass index (BMI)	1.8	7.6	13.4	1.4	2.6	2.6	3.6	3.7	1.9
Forced vital capacity (FVC), Best measure	1.8	6.7	16.8	3.1	1.7	-0.7	-4.1	-0.3	3.1
Worry too long after embarrassment	1.8	3.1	7.2	-1.5	-1.9	-1.6	-1.6	-0.6	-2.7
Height	1.7	32.2	123.2	4.3	-0.5	-5.3	-11.1	-3.8	2.9
Medication for hormone replacement therapy	1.7	1.9	9.5	-0.3	-0.1	1.3	3.1	0.3	-0.2
Waist circumference	1.7	6.3	7.8	2.3	2.8	2.5	2.3	2.7	2.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.4	14.7	2.5	1.1	-0.9	-3.8	-0.7	2.9
Medication for cholesterol	1.7	2.6	10.1	1.5	1.2	-0.6	-3.2	-0.7	1.0
Arm fat mass (left)	1.7	7.2	9.4	2.4	3.1	2.4	2.3	2.9	2.9
Age when periods started (menarche)	1.6	3.8	5.0	-1.3	-1.7	-2.1	-2.1	-2.1	-2.2
Forced expiratory volume in 1-second (FEV1)	1.6	5.3	19.4	1.7	0.2	-1.8	-4.4	-1.4	2.0
Arm fat mass (right)	1.6	6.7	9.3	2.4	3.0	2.2	2.1	2.8	2.8
Eye problems/disorders: Cataract	1.6	1.8	3.1	1.2	1.8	1.6	1.5	-0.0	1.2
Forced vital capacity (FVC)	1.5	5.8	20.1	2.4	1.0	-1.4	-4.5	-0.6	2.3
Average weekly red wine intake	1.5	2.3	4.3	-0.8	-0.8	-1.6	-2.1	-1.9	-1.4
Medication: Lisinopril	1.5	2.0	4.0	-2.0	-1.9	-1.0	0.1	-0.5	-1.8
Commuting to job workplace: Cycle	1.5	1.8	4.7	-0.5	-1.2	-1.1	-1.0	-2.2	-1.4
Major Depression (MDD)	1.4	1.7	6.6	0.5	-0.7	-1.3	-2.6	-0.7	0.7
Lung FEV1/FVC ratio	1.4	7.3	12.8	-3.0	-3.6	-2.9	-2.1	-2.5	-1.7
Pack years adult smoking proportion	1.4	2.1	4.1	-1.7	-1.9	-0.9	0.2	1.1	-2.0
Serious illness, injury or assault to yourself	1.4	1.7	4.5	0.5	1.2	1.5	2.1	0.0	1.2
Exposure to tobacco smoke at home	1.4	1.5	2.2	1.3	1.4	1.5	1.2	1.2	0.5
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	3.2	-1.0	-1.5	-1.8	-1.7	-1.6	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	8.6	0.4	-1.1	-2.0	-2.9	-1.8	0.6
Father’s age at death	1.3	1.8	2.8	1.6	1.7	1.7	1.1	0.3	1.2
Birth weight	1.3	2.8	4.8	-2.1	-1.4	-2.2	-1.3	-1.1	-1.6
Reaction Time	1.2	2.3	4.1	1.6	1.9	1.5	0.2	2.0	1.3
Allergy or Eczema	1.2	3.1	5.7	2.2	2.4	1.7	0.1	-0.1	2.3
Illnesses of father: None of the above (group 1)	1.2	1.5	2.6	-1.5	-1.5	-1.6	-1.1	-0.4	-0.8
Ever taken oral contraceptive pill	1.2	1.3	2.7	-1.2	-1.6	-1.2	-0.8	-0.9	-0.9
Supplements: Fish oil (including cod liver oil)	1.2	1.6	1.9	-1.1	-1.3	-1.4	-1.3	-1.4	-1.0
Fasting Glucose	1.1	1.3	2.4	-1.5	-0.9	-1.1	0.1	-1.2	-1.5
Eye problems/disorders: None of the above	1.1	1.3	2.2	-1.2	-1.5	-1.1	-0.7	-0.7	-1.4
Comparative height size at age 10	1.1	6.0	20.7	0.8	-0.9	-3.0	-4.6	-2.0	0.9
Number of full sisters	1.1	1.4	2.6	-1.6	-1.2	-1.2	-0.3	0.4	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	2.7	0.2	1.1	1.0	1.6	1.3	0.7
Mother’s age at death	1.1	1.4	3.8	1.9	1.1	1.1	-0.4	0.3	1.5
Average weekly beer plus cider intake	1.1	1.5	3.8	-1.7	-0.2	0.2	2.0	1.2	-1.0
Heart disease (siblings)	1.1	1.4	8.0	0.2	0.0	0.0	-0.4	2.8	0.2
Alzheimer’s Disease (in father)	1.0	1.1	2.8	-1.3	-1.1	-0.7	-0.2	-0.4	-1.7
Smoking Status	1.0	2.4	4.2	-2.1	-2.0	-1.8	-0.5	0.7	-1.4
Supplements: Zinc	1.0	1.1	2.4	1.5	1.1	0.8	-0.2	-0.2	1.6
Stomach or abdominal pain in last month	1.0	1.3	1.8	1.2	1.2	1.1	1.3	0.6	1.2
Allergy	1.0	2.2	4.4	-2.1	-1.6	-1.2	0.7	-1.3	-1.7
Falls in the last year	1.0	1.4	4.2	2.1	1.3	1.3	0.2	0.6	0.7
Asthma	1.0	2.0	3.0	1.7	1.5	1.6	0.2	1.6	1.2
Glaucoma (self-reported)	1.0	1.2	2.6	1.2	1.5	0.5	-0.4	0.8	1.6
Number of full brothers	1.0	1.3	2.6	-1.3	-1.1	-0.6	0.6	1.2	-1.6
Shortness of breath walking on level ground	1.0	1.2	2.4	0.6	0.5	1.3	1.5	1.5	0.5
Migraine (self-reported)	1.0	1.2	3.7	-0.1	-0.5	-0.8	-1.6	-1.9	0.1
Mean time to correctly identify matches	1.0	1.9	3.4	1.5	1.6	1.3	-0.2	1.8	1.2
Leg fat-free mass (right)	1.0	5.2	13.8	-0.5	-1.7	-3.5	-3.7	-1.4	-0.2
Leg predicted mass (right)	1.0	5.1	13.7	-0.5	-1.7	-3.4	-3.7	-1.4	-0.2
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.3	-1.4	-1.0	-1.0	0.0	-1.5	-0.9
Eye problems/disorders: Glaucoma	1.0	1.2	2.5	1.3	1.4	0.4	-0.7	0.3	1.6
High cholesterol (Self-reported)	1.0	1.8	3.6	-1.9	-1.9	-1.3	0.7	-0.4	-1.1
Number of operations (self-reported)	1.0	1.5	4.8	0.4	0.7	0.9	1.5	2.2	0.4
Worry (Nagel 2018)	0.9	1.9	4.7	-1.0	-1.7	-1.3	-1.1	-0.4	-2.2
Ulcerative Colitis (UC)	0.9	1.6	2.8	1.3	1.4	1.3	1.1	0.4	1.7
Blood Platelet Count	0.9	10.4	20.0	2.4	2.6	3.1	2.2	4.5	3.9
BMI	0.9	5.5	11.2	1.1	2.2	2.3	3.3	2.7	1.7
Frequency of depressed mood in last 2 weeks	0.9	1.3	4.1	1.4	0.8	0.7	-0.1	2.0	0.9
Systolic blood pressure, automated reading	0.9	2.6	3.8	-1.9	-1.8	-1.4	-0.9	1.7	-1.8
Diabetes (mother)	0.9	1.1	5.9	0.2	0.3	0.3	0.6	2.4	0.2
Relative age voice broke	0.9	1.4	4.8	-0.8	-0.6	-1.0	-1.1	-2.2	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	7.6	-1.3	-0.1	1.0	2.8	1.4	-0.3
Qualifications: None of the above	0.9	2.0	5.1	0.9	0.8	1.9	2.3	1.1	0.5
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	1.8	1.3	1.3	1.2	0.6	-0.1	1.3
Prospective memory result	0.9	1.1	4.1	-0.4	0.1	0.5	1.4	2.0	0.2
Overall health rating	0.9	2.0	5.9	0.6	0.9	1.7	2.4	1.4	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.7	-1.3	-1.0	-1.3	-1.0	-0.2	-0.6
Medication: Gliclazide	0.9	1.1	2.4	-1.5	-0.8	-0.1	1.5	0.7	-0.8
Medication: Blood pressure	0.9	1.7	3.1	-1.8	-1.7	-0.7	0.7	0.3	-1.8
Medication: Paracetamol	0.9	1.3	1.8	0.9	1.2	1.3	1.1	1.4	1.0
Unable to work because of sickness or disability	0.9	1.2	2.0	1.4	1.2	1.2	0.6	1.1	0.9
Breast Cancer	0.8	1.8	3.4	-1.8	-0.9	-1.4	-0.9	-1.6	-1.2
Schizophrenia (2014)	0.8	1.8	4.0	1.8	2.0	1.2	-0.2	-0.3	1.3
Lung FVC	0.8	3.9	9.2	1.9	1.5	0.0	-1.9	3.0	2.1
Number of treatments/medications taken	0.8	1.4	4.2	0.0	0.7	1.1	2.0	1.6	0.6
Average weekly spirits intake	0.8	1.0	4.9	0.1	0.1	-0.3	-0.0	-2.2	-0.8
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.1	1.5	1.0	0.8	0.0	1.1	1.2
Angina	0.8	1.1	2.1	-1.3	-1.4	-0.7	-0.2	-0.6	-1.4
Qualifications: CSEs or equivalent	0.8	1.1	1.8	1.1	0.6	1.3	1.2	0.1	1.2
Hearing difficulty/problems with background noise	0.8	1.3	3.6	-1.3	-0.9	-0.9	-0.2	0.8	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	6.7	-1.1	-0.1	1.0	2.6	1.3	-0.3
Weight	0.8	4.0	7.9	2.8	2.3	0.9	-0.2	1.6	2.8
Trunk fat-free mass	0.8	4.4	16.3	1.6	-0.4	-2.2	-4.0	-1.0	1.3
Time employed in main current job	0.8	0.9	2.7	0.5	0.6	0.7	1.0	-1.6	0.9
Happiness	0.8	1.0	1.9	0.6	0.9	1.4	1.2	1.3	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	3.0	0.8	0.7	0.2	-0.7	1.7	0.8
Trunk predicted mass	0.8	4.3	16.0	1.7	-0.2	-2.1	-4.0	-0.9	1.4
Comparative body size at age 10	0.8	2.1	6.3	0.2	1.3	1.2	2.5	1.4	1.0
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.6	-1.1	-1.1	-0.4	0.5	0.3	-1.6
Medication: Seretide 50 evohaler	0.8	0.9	2.1	0.3	0.8	0.9	1.1	1.4	0.9
Had major operations	0.8	1.0	3.7	-0.7	-0.6	-0.8	-0.5	1.9	-0.6
Medication: Aspirin	0.8	1.1	2.3	-1.3	-1.5	-0.9	-0.1	-0.2	-1.4
Asthma (self-reported)	0.8	1.6	2.7	1.6	1.4	1.4	-0.1	1.2	1.1
Average weekly champagne plus white wine intake	0.8	1.1	2.2	1.5	1.3	1.1	0.2	1.0	0.6
Financial situation satisfaction	0.8	1.0	2.0	0.5	1.0	1.2	1.4	1.0	0.3
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	2.7	1.7	0.9	0.5	-0.8	0.8	1.2
Bipolar Disorder (2011)	0.7	0.6	2.2	0.5	0.0	-0.5	-1.5	-0.5	0.9
Heel T-Score	0.7	5.9	17.5	-2.9	-1.7	0.9	4.2	0.3	-2.4
Waist Hip Ratio (WHR)	0.7	3.2	6.1	1.3	1.6	2.5	1.9	1.6	1.4
Systolic Blood Pressure	0.7	3.5	5.5	-2.2	-2.4	-1.8	-1.6	0.5	-2.1
Medication: Metformin	0.7	1.0	2.6	0.1	0.6	1.0	1.6	1.2	0.6
Fed-up feelings	0.7	1.3	3.6	1.0	0.9	1.1	1.0	1.9	0.3
Multivitamins +/- minerals	0.7	0.9	2.5	-0.5	-1.0	-1.1	-1.6	-0.3	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	2.3	1.3	1.1	0.9	0.3	1.5	0.4
Heart attack	0.7	0.9	2.3	1.5	0.9	1.2	0.2	-0.3	0.7
Pulse wave reflection index	0.7	0.9	1.6	-0.9	-1.0	-0.2	1.2	-0.5	-1.3
Exposure to tobacco smoke outside home	0.7	0.9	2.6	0.7	1.0	1.0	0.4	1.6	0.4
Pulse wave peak to peak time	0.7	0.8	1.6	0.7	0.6	0.0	-1.1	-1.3	0.9
Medication: Blood pressure	0.7	1.3	1.6	-1.3	-1.3	-1.3	-1.1	0.4	-1.2
Whole body fat-free mass	0.7	3.8	13.7	1.1	-0.6	-2.4	-3.7	-0.8	0.9
Qualifications: nursing, teaching	0.7	1.1	4.6	-0.3	0.0	-1.3	-2.1	-0.5	0.3
Medication: Aspirin	0.7	0.8	1.6	-1.3	-1.2	-0.6	0.4	0.0	-1.2
Whole body water mass	0.7	3.8	13.7	1.1	-0.6	-2.4	-3.7	-0.8	1.0
Number of self-reported non-cancer illnesses	0.7	1.1	5.1	0.0	0.4	0.6	0.7	2.3	0.9
Irritability	0.7	1.1	2.1	0.7	1.1	1.1	1.2	1.4	0.5
Pain experienced in last month	0.7	1.1	2.2	-1.5	-0.5	-0.4	0.3	-1.4	-1.5
HDL Cholesterol	0.6	0.9	3.8	0.1	0.7	1.1	2.0	0.2	-0.0
Triglycerides	0.6	1.0	2.8	-0.4	-0.8	-0.9	-1.7	1.2	-0.2
Ulcerative Colitis	0.6	0.8	2.1	1.2	0.8	0.5	-0.3	0.3	1.5
Chronotype (morning person)	0.6	1.4	4.9	0.0	-0.6	-1.2	-2.2	-1.3	0.1
Hearing difficulty/problems: Yes	0.6	0.9	2.1	-0.0	1.1	0.9	1.1	1.5	0.4
Vitamin and mineral supplements	0.6	0.8	2.4	-1.0	-0.1	0.3	1.6	-0.2	-1.0
Leg fat-free mass (left)	0.6	3.0	10.6	0.5	-0.6	-2.5	-3.3	-0.7	0.6
Leg predicted mass (left)	0.6	3.0	10.6	0.5	-0.6	-2.4	-3.3	-0.6	0.6
Pain all over the body in last month	0.6	0.7	0.8	0.9	0.9	0.8	0.8	0.8	0.8
Diabetes (self-reported)	0.6	0.9	2.4	-0.9	-0.6	0.4	1.6	1.1	-0.6
Illnesses of siblings	0.6	0.9	4.4	-0.0	-0.3	-0.4	-0.7	-2.1	-0.4
Hip circumference	0.6	2.4	4.9	1.7	2.2	0.8	0.5	1.7	1.7
Hair/balding pattern: Pattern 3	0.6	0.9	1.4	1.1	0.9	1.1	0.4	1.2	0.9
Mouth/teeth dental problems: Dentures	0.6	1.0	4.5	-0.5	0.6	0.8	2.1	0.5	-0.0
Birth weight of first child	0.6	1.1	2.2	-1.5	-0.8	-1.0	-0.6	-0.9	-1.2
Medication: Ventolin 100micrograms inhaler	0.6	0.7	3.5	0.2	0.2	0.5	0.7	1.9	-0.1
Qualifications: College or University degree	0.6	2.0	8.1	0.2	-0.4	-1.6	-2.8	-1.0	0.2
Leg pain on walking	0.6	0.7	1.5	0.6	0.4	0.9	1.2	0.9	0.7
Handedness (chirality/laterality): Left-handed	0.6	0.7	3.5	-0.6	-0.2	-0.6	-0.1	-1.9	-0.1
Diabetes diagnosed by doctor	0.6	1.0	2.8	-0.6	-0.2	0.7	1.7	1.5	-0.2
Back pain experienced in last month	0.6	0.8	2.8	0.1	-1.1	-1.0	-1.7	-0.4	-0.1
Breast cancer (self-reported)	0.6	0.8	3.1	0.7	0.7	0.5	0.1	1.7	0.5
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.9	1.4	0.9	1.0	0.2	-0.6	0.7
Pack years of smoking	0.6	0.9	1.8	-0.9	-1.0	-0.1	0.7	1.3	-1.3
Impedance of whole body	0.6	3.2	6.0	2.5	2.2	2.2	0.4	-0.7	1.7
Bipolar Disorder (2018)	0.5	0.8	2.4	-0.3	-0.6	-0.9	-1.5	-0.1	-1.1
Depression (Nagel 2018)	0.5	0.7	1.7	1.3	0.6	0.1	-0.9	0.9	0.8
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.8	-0.9	-0.7	-1.8	-2.0	-1.0	-0.8
Prostate Cancer	0.5	0.7	1.5	-0.9	-0.9	-1.2	-1.0	-0.5	-0.4
Rheumatoid Arthritis	0.5	0.7	2.0	-0.6	-1.4	-0.5	0.7	-0.6	-0.6
Relative age of first facial hair	0.5	1.1	3.8	0.9	0.6	-0.2	-2.0	-1.1	0.6
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.6	-0.8	-0.3	0.6	1.6	0.1	-0.7
Ever had hysterectomy (womb removed)	0.5	0.6	1.2	-0.7	-1.0	0.0	0.8	0.0	-1.1
Severe depression (siblings)	0.5	0.5	2.2	-0.1	-0.3	-0.8	-1.5	0.0	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.9	0.8	1.0	0.3	-0.1	1.4	0.7
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.2	-0.2	-0.6	-0.2	-0.4	1.5	-0.8
Medication: Simvastatin	0.5	0.7	1.5	-1.2	-0.9	-0.7	0.2	-0.7	-1.0
Impedance of arm (right)	0.5	2.1	6.3	1.0	0.5	-0.4	-2.5	-2.3	0.4
Qualifications: A levels/AS levels or equivalent	0.5	1.0	2.1	-0.6	-0.6	-1.4	-1.2	-1.4	-0.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.5	1.2	1.1	1.2	0.6	-0.3	0.9
Wheeze or whistling in the chest in last year	0.5	0.8	1.7	-0.1	-0.9	-1.1	-1.3	-1.1	0.2
Age at first live birth	0.5	0.9	3.4	-0.6	0.0	-0.5	-0.7	-1.9	-0.8
Angina (self-reported)	0.5	0.7	1.5	-1.0	-1.2	-0.6	-0.3	-0.4	-1.1
Medication: Omeprazole	0.5	0.6	1.9	-0.5	-0.5	0.0	0.5	1.4	-0.9
Heart disease (mother)	0.5	0.5	1.3	-0.2	-1.1	-0.7	-0.5	0.5	-1.0
Illnesses of siblings: Diabetes	0.5	0.6	2.0	0.4	0.5	0.9	1.4	-0.1	0.8
Smoking status: Previous	0.5	0.8	2.0	0.9	0.7	0.6	0.3	1.4	0.9
Mood swings	0.5	0.9	1.3	1.0	1.0	1.1	0.9	0.9	0.6
Ever had bowel cancer screening	0.5	0.6	1.7	1.2	0.4	0.2	-0.4	0.6	1.3
Mineral and other dietary supplements	0.5	0.7	2.1	0.1	0.5	0.5	1.1	1.4	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.1	1.5	1.0	0.2	-1.3	-0.1	1.4
Arm fat-free mass (left)	0.5	2.3	4.5	2.1	0.9	-0.6	-1.8	0.8	2.1
Myopia	0.5	0.8	1.7	-0.4	-0.6	-1.0	-1.3	1.1	-0.6
Cholesterol lowering medication	0.5	0.7	1.8	-0.5	-0.6	0.2	1.2	1.4	-0.2
Alcohol drinker status: Previous	0.5	0.5	1.8	-0.1	-0.0	0.5	1.4	1.0	-0.2
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.7	0.1	-0.0	-0.9	-1.5	-1.6	-0.5
Ovarian Cancer	0.4	0.5	1.1	0.6	1.1	0.9	0.6	0.4	0.6
Crohns Disease (2012)	0.4	0.6	1.1	1.1	0.4	0.7	0.8	0.1	1.0
HbA1C	0.4	0.5	0.9	0.9	0.3	0.8	0.7	0.9	-0.3
LDL Cholesterol	0.4	0.6	1.8	-0.7	-0.0	-0.3	-0.3	-1.3	-1.1
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.6	-1.0	-0.6	0.3	1.6	0.5	-0.8
Townsend deprivation index at recruitment	0.4	0.5	1.0	-1.0	-0.4	-1.0	-0.5	0.7	-0.3
Average weekly fortified wine intake	0.4	0.4	2.0	0.2	0.6	0.1	0.3	-1.4	0.3
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.4	1.2	0.9	0.4	-1.0	-0.1	1.2
Nervous feelings	0.4	0.8	3.1	-0.3	-0.6	-0.5	-1.0	-0.4	-1.8
Neuroticism score	0.4	0.8	2.4	-0.7	-0.9	-0.7	-0.5	0.6	-1.6
Worrier / anxious feelings	0.4	0.7	2.2	-0.6	-0.7	-0.5	-0.5	0.7	-1.5
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.9	-0.7	-0.6	-0.8	-1.0	-0.6	0.1
Blood clot in the leg (DVT)	0.4	0.5	1.3	1.2	0.6	0.2	-0.9	0.3	0.7
Headache pain in last month	0.4	0.7	2.3	0.3	-0.1	-0.8	-1.5	-0.9	0.5
Medication: Amlodipine	0.4	0.6	2.8	0.2	0.2	0.2	0.7	1.7	0.2
Health satisfaction	0.4	0.6	1.6	0.2	0.2	0.6	1.1	1.3	0.1
Medication: Allopurinol	0.4	0.5	1.1	0.7	0.6	0.7	1.0	-0.2	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.7	-0.3	-0.3	0.6	1.3	-0.2	-0.9
Pulse rate, automated reading	0.4	1.2	2.6	-1.6	-1.2	-1.1	-0.5	-0.0	-1.3
Suffer from ‘nerves’	0.4	0.6	1.6	-0.4	-0.9	-0.6	-0.8	-0.0	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.1	-0.1	1.0	0.5	1.1	-0.2	0.5
Osteoarthritis (self-reported)	0.4	0.6	1.3	0.3	0.8	0.6	0.7	1.1	0.8
Basal metabolic rate	0.4	2.4	7.2	1.6	0.3	-1.5	-2.7	-0.1	1.6
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	1.1	0.8	0.1	-0.6	0.1	0.9
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.6	-0.5	-0.6	-0.2	0.1	1.3	-0.9
Arm predicted mass (left)	0.4	2.2	4.1	2.0	0.7	-0.8	-1.9	0.8	1.9
Bipolar Disorder or Schizophrenia	0.3	0.7	2.3	0.4	0.5	-0.3	-1.5	-1.0	-0.5
Schizophrenia (2018)	0.3	0.6	1.4	0.8	1.1	0.4	-0.7	-1.2	0.2
Alzheimer’s Disease (including proxy)	0.3	0.4	1.0	-0.8	-0.7	-0.4	-0.0	-0.6	-1.0
Irritable Bowel Disease (IBD)	0.3	0.7	1.6	1.1	0.8	0.6	0.5	-0.2	1.3
Coronary Artery Disease (CAD)	0.3	0.4	1.1	0.1	0.6	0.5	0.8	0.4	1.0
Mean Putamen Volume	0.3	0.4	1.0	-1.0	-0.5	-0.6	-0.2	0.4	-0.7
Blood Red Count	0.3	3.3	8.2	1.3	1.7	2.1	1.5	2.9	0.8
Blood White Count	0.3	2.6	11.5	-0.8	-1.1	-0.9	-1.1	3.4	-0.3
Maternal smoking around birth	0.3	0.4	1.6	-0.3	-0.5	0.3	1.3	0.5	0.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.4	0.3	0.2	0.0	-0.3	1.2	0.4
Medication: Atenolol	0.3	0.3	0.7	-0.6	-0.8	-0.4	0.1	-0.1	-0.8
Hair/balding pattern: Pattern 2	0.3	0.4	1.1	-0.7	-0.3	-0.1	1.0	-0.8	-0.4
Fluid intelligence score	0.3	0.6	1.5	0.7	0.8	-0.0	-1.2	-1.1	-0.2
Medication: Cholesterol lowering	0.3	0.5	0.9	-0.9	-0.7	-0.6	0.4	-0.9	-0.5
Pulse wave Arterial Stiffness index	0.3	0.4	1.0	-0.4	-0.5	-0.2	0.5	1.0	-0.7
Impedance of arm (left)	0.3	1.5	4.9	0.9	0.4	-0.1	-1.8	-2.2	0.2
Tense / ‘highly strung’	0.3	0.5	1.8	0.2	-0.4	-0.3	-0.2	1.3	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.3	0.7	0.9	0.4	0.0	0.4	1.1
Loud music exposure frequency	0.3	0.3	1.3	0.2	-0.1	-0.3	-0.6	-1.1	0.2
High blood pressure (siblings)	0.3	0.4	1.5	-0.6	-0.6	-0.4	0.3	1.2	-0.3
Arm fat-free mass (right)	0.3	1.8	3.4	1.8	0.4	-0.9	-1.9	0.2	1.7
Neck or shoulder pain in last month	0.3	0.4	0.8	0.7	0.9	0.6	0.6	-0.3	0.4
Arm predicted mass (right)	0.3	1.6	3.6	1.5	0.2	-1.1	-1.9	0.3	1.5
Age at last live birth	0.3	0.4	1.3	-0.4	0.5	-0.3	-0.8	-1.1	-0.1
Ever smoked	0.3	0.6	1.3	-0.8	-1.1	-1.1	-0.6	0.2	-0.4
Risk taking	0.3	0.5	0.8	-0.9	-0.4	-0.9	-0.4	-0.8	-0.6
Supplements: Calcium	0.3	0.3	1.3	0.1	-0.5	-0.2	-1.1	0.4	-0.3
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	0.3	0.7	0.4	0.4	-0.1	0.5
Age at First Birth	0.2	0.3	0.9	-0.1	-0.2	0.2	0.4	-1.0	-0.9
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	0.1	0.5	0.2	0.7	-0.3	0.2
High blood pressure (mother)	0.2	0.2	0.9	-0.2	-0.1	0.4	1.0	0.5	-0.1
Past tobacco smoking	0.2	0.3	1.3	0.1	0.3	0.5	0.5	-1.1	-0.2
Medication: Ramipril	0.2	0.2	0.3	-0.5	-0.5	-0.3	0.4	-0.6	-0.2
Alcohol intake versus 10 years previously	0.2	0.4	0.7	0.4	0.6	0.5	0.5	0.6	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.6	0.2	0.8	0.7	0.6	0.5	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.7	0.1	0.8	0.3	0.1	-0.7	0.4
Depression (self-reported)	0.2	0.2	0.5	0.6	0.6	0.4	-0.1	0.2	0.7
Lung cancer (father)	0.2	0.2	0.6	-0.5	-0.1	0.2	0.8	0.6	0.1
Length of working week for main job	0.2	0.2	0.4	-0.6	-0.4	-0.6	-0.3	0.4	-0.6
Breastfed as a baby	0.2	0.2	0.9	0.3	0.3	0.5	0.2	1.0	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.9	0.2	-0.7	-0.1	-0.1	1.0	0.0
Medication for pain relief, constipation, heartburn	0.2	0.3	1.0	0.1	-0.3	-0.3	-0.6	-1.0	0.2
Medication: Ibuprofen	0.2	0.2	0.4	0.0	0.6	0.5	0.7	-0.5	0.3
Alcohol intake frequency.	0.2	0.5	1.0	-1.0	-0.9	-0.4	0.2	0.4	-0.7
Chest pain or discomfort	0.2	0.2	0.5	0.7	-0.3	0.1	-0.4	0.5	0.6
Long-standing illness, disability or infirmity	0.2	0.3	0.8	0.4	0.4	0.0	-0.3	0.9	0.9
Osteoporosis (self-reported)	0.2	0.3	0.9	0.8	0.0	-0.1	-0.9	-0.4	0.3
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.9	-0.4	0.0	0.1	0.6	-0.9	0.3
Medication: Bendroflumethiazide	0.2	0.4	0.9	-1.0	-0.2	-0.2	0.6	0.4	-0.8
Medication: Atorvastatin	0.2	0.2	0.4	0.1	-0.7	-0.5	-0.6	0.1	0.3
Age started oral contraceptive pill	0.2	0.3	1.0	-0.3	-0.6	-0.4	-0.4	-0.3	-1.0
Basal cell carcinoma (self-reported)	0.2	0.3	0.6	0.2	0.6	0.3	0.5	-0.8	0.6
Neuroticism (Nagel 2018)	0.1	0.2	1.1	0.4	-0.0	0.3	-0.1	0.0	-1.0
Crohns Disease (2017)	0.1	0.2	0.7	0.3	-0.1	-0.2	0.0	-0.9	0.3
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.6	0.2	0.2	0.1	-0.1	0.8	-0.0
Neuroticism	0.1	0.2	0.4	0.5	-0.0	0.3	0.0	0.5	-0.6
Hair Pigment	0.1	1.7	6.5	0.6	0.0	1.5	2.5	0.8	0.8
Sensitivity / hurt feelings	0.1	0.2	0.8	-0.4	-0.0	-0.2	0.1	0.2	-0.9
Supplements: Glucosamine	0.1	0.1	0.2	-0.2	-0.4	-0.4	-0.4	-0.2	0.4
Alcohol usually taken with meals	0.1	0.1	0.4	-0.3	-0.4	-0.3	-0.3	-0.2	-0.6
Pulse rate	0.1	0.2	0.6	-0.8	-0.2	-0.0	0.7	0.4	-0.4
Gout (self-reported)	0.1	0.1	0.4	-0.1	-0.0	0.1	0.6	-0.6	0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	0.2	-0.3	0.3	0.2	0.3	-0.2
Number of children fathered	0.1	0.2	0.6	0.0	0.2	0.2	0.8	0.3	0.4
Emphysema/chronic bronchitis	0.1	0.1	0.3	-0.1	-0.1	0.1	0.5	-0.3	0.3
Knee pain experienced in last month	0.1	0.2	0.6	0.4	0.0	-0.0	0.3	0.5	0.8
Illnesses of father: Heart disease	0.1	0.2	0.6	0.1	0.8	0.2	0.4	0.6	0.0
Loneliness, isolation	0.1	0.2	0.6	-0.2	-0.0	-0.0	0.1	0.8	-0.5
Miserableness	0.1	0.2	0.9	-0.1	0.1	-0.0	-0.2	1.0	-0.0
Guilty feelings	0.1	0.2	0.5	0.7	0.1	0.3	-0.7	-0.4	-0.2
Wears glasses or contact lenses	0.1	0.2	0.5	0.1	0.2	-0.0	-0.5	0.7	0.2
Illnesses of father: High blood pressure	0.1	0.1	0.5	-0.5	-0.2	-0.0	0.7	-0.2	0.3
Depressed Affect (Nagel 2018)	0.0	0.1	0.4	0.2	-0.1	0.2	0.1	-0.1	-0.7
Tanning	0.0	0.3	0.7	-0.1	-0.8	-0.1	-0.2	-0.8	-0.8

Hub : Genes

DLEU1

Models

Trait associations