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chr16:10,325,245-12,138,068

Best TWAS P=6.57e-114 · Best GWAS P=8.31e-124 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RMI2	0.49	0.43	bslmm	534	0.57	4.4e-84	-8.62	-5.3	1.4e-07	0.07	1.00	0.00	FALSE
2	GTEx	Adipose Visceral Omentum	DEXI	0.17	0.02	enet	27	0.03	1.3e-02	-17.00	-17.9	1.8e-71	0.53	0.07	0.85	FALSE
3	GTEx	Adipose Visceral Omentum	RP11-876N24.5	0.11	0.08	lasso	2	0.10	6.0e-06	-19.95	-18.7	9.6e-78	0.68	0.06	0.92	FALSE
4	GTEx	Brain Cortex	RMI2	0.55	0.15	enet	10	0.17	2.3e-05	-8.62	-6.2	4.6e-10	0.04	0.73	0.02	FALSE
5	GTEx	Brain Frontal Cortex BA9	RMI2	0.55	0.26	enet	17	0.26	1.6e-07	-8.62	-8.2	3.5e-16	0.14	0.86	0.01	TRUE
6	GTEx	Brain Putamen basal ganglia	RMI2	0.48	0.31	lasso	9	0.40	1.7e-10	-9.47	-10.7	1.1e-26	0.34	0.69	0.03	FALSE
7	GTEx	Breast Mammary Tissue	RMI2	0.37	0.25	lasso	7	0.21	3.5e-11	-8.62	-5.8	5.6e-09	0.03	1.00	0.00	FALSE
8	GTEx	Breast Mammary Tissue	DEXI	0.12	0.07	enet	14	0.08	6.9e-05	-18.89	-19.5	8.2e-85	0.72	0.06	0.89	TRUE
9	GTEx	Breast Mammary Tissue	RP11-876N24.5	0.15	0.11	enet	19	0.12	1.4e-06	-18.89	-20.0	2.9e-89	0.73	0.28	0.70	FALSE
10	GTEx	Breast Mammary Tissue (Male)	RMI2	0.32	0.15	enet	25	0.10	2.9e-03	-9.47	-10.7	6.0e-27	0.26	0.07	0.12	FALSE
11	GTEx	Breast Mammary Tissue (Male)	DEXI	0.18	0.04	lasso	3	-0.01	4.9e-01	-21.75	-22.7	6.6e-114	0.63	0.03	0.64	TRUE
12	GTEx	Breast Mammary Tissue (Male)	RP11-876N24.5	0.16	0.24	lasso	2	0.21	1.5e-05	-11.26	-12.1	6.2e-34	0.36	0.07	0.22	FALSE
13	GTEx	Breast Mammary Tissue (Female)	RMI2	0.19	0.06	lasso	6	0.09	1.6e-03	6.86	7.7	1.1e-14	-0.13	0.12	0.06	FALSE
14	GTEx	Breast Mammary Tissue (Female)	DEXI	0.13	0.06	lasso	2	0.04	2.0e-02	-20.76	-20.5	8.2e-94	0.79	0.05	0.52	FALSE
15	GTEx	Breast Mammary Tissue (Female)	RP11-876N24.5	0.22	0.14	enet	11	0.13	1.0e-04	-15.97	-18.8	9.3e-79	0.77	0.14	0.75	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	RMI2	0.50	0.06	enet	11	0.35	4.3e-12	-4.23	5.4	6.4e-08	-0.02	0.82	0.01	TRUE
17	GTEx	Cells Transformed fibroblasts	RMI2	0.17	0.04	lasso	7	0.07	9.0e-06	7.64	6.1	1.3e-09	-0.06	0.93	0.00	FALSE
18	GTEx	Cells Transformed fibroblasts	DEXI	0.12	0.05	lasso	5	0.08	9.6e-07	-20.12	-21.5	4.0e-102	0.72	0.17	0.82	FALSE
19	GTEx	Cells Transformed fibroblasts	RP11-876N24.4	0.12	0.04	lasso	5	0.08	2.1e-06	-20.12	-21.6	6.6e-104	0.73	0.17	0.82	FALSE
20	GTEx	Colon Sigmoid	RMI2	0.30	0.09	enet	11	0.12	6.2e-05	-8.66	-6.9	5.0e-12	0.05	0.80	0.01	FALSE
21	GTEx	Esophagus Muscularis	RMI2	0.35	0.20	enet	71	0.23	7.4e-14	-8.62	-5.3	9.1e-08	0.10	1.00	0.00	FALSE
22	GTEx	Heart Atrial Appendage	RMI2	0.33	0.13	lasso	8	0.10	4.0e-05	-8.95	-8.1	4.7e-16	0.13	0.41	0.05	FALSE
23	GTEx	Muscle Skeletal	DEXI	0.06	0.00	lasso	4	0.00	6.4e-01	12.22	-7.6	3.1e-14	0.09	0.11	0.11	TRUE
24	GTEx	Nerve Tibial	RMI2	0.50	0.24	enet	35	0.38	5.9e-28	0.32	-5.5	3.0e-08	0.14	1.00	0.00	TRUE
25	GTEx	Nerve Tibial	DEXI	0.11	0.05	enet	7	0.07	1.7e-05	-18.89	-21.3	4.1e-101	0.81	0.64	0.28	FALSE
26	GTEx	Ovary	RMI2	0.48	0.26	lasso	9	0.20	1.2e-05	-9.47	-5.8	9.1e-09	0.01	0.34	0.04	FALSE
27	GTEx	Pancreas	DEXI	0.13	0.06	lasso	4	0.07	5.7e-04	-20.03	-20.9	1.5e-96	0.67	0.18	0.68	FALSE
28	GTEx	Pancreas	RP11-876N24.4	0.11	0.05	lasso	3	0.04	8.6e-03	-20.03	-21.1	1.3e-98	0.67	0.15	0.67	FALSE
29	GTEx	Pituitary	RMI2	0.52	0.18	enet	6	0.32	6.6e-09	-8.66	-6.7	2.7e-11	0.04	0.43	0.03	FALSE
30	GTEx	Skin Sun Exposed Lower leg	DEXI	0.05	0.06	lasso	2	0.03	7.8e-04	-20.03	-19.7	3.6e-86	0.65	0.70	0.21	FALSE
31	GTEx	Testis	CLEC16A	0.15	0.00	enet	20	0.01	1.2e-01	-20.09	-21.0	1.7e-97	0.71	0.02	0.92	FALSE
32	GTEx	Testis	DEXI	0.21	0.11	lasso	3	0.08	2.1e-04	-17.80	-20.9	2.9e-97	0.68	0.29	0.32	FALSE
33	GTEx	Testis	RP11-876N24.4	0.21	0.06	lasso	5	0.07	6.0e-04	-17.80	-20.2	1.2e-90	0.70	0.21	0.30	FALSE
34	GTEx	Thyroid	RMI2	0.44	0.31	enet	37	0.40	2.2e-32	-8.66	-5.9	3.7e-09	0.07	1.00	0.00	FALSE
35	GTEx	Thyroid	DEXI	0.08	0.00	enet	18	0.03	1.8e-03	-20.03	-19.9	5.4e-88	0.53	0.18	0.66	FALSE
36	GTEx	Thyroid	RP11-876N24.4	0.06	0.00	enet	17	0.02	1.5e-02	13.32	-16.3	5.5e-60	0.43	0.18	0.33	TRUE
37	GTEx	Thyroid	RP11-396B14.2	0.12	0.01	lasso	6	0.01	4.0e-02	-17.64	19.3	4.2e-83	-0.80	0.01	0.96	TRUE
38	METSIM	Adipose	RMI2	0.20	0.18	lasso	8	0.26	3.0e-38	-8.66	-5.5	3.6e-08	0.05	1.00	0.00	FALSE
39	ROSMAP	Brain Pre-frontal Cortex	DEXI	0.12	0.12	lasso	6	0.13	5.9e-16	-19.37	-20.8	2.5e-96	0.70	1.00	0.00	FALSE
40	YFS	Blood	DEXI	0.11	0.15	enet	29	0.16	2.6e-51	-19.37	-19.5	2.4e-84	0.66	1.00	0.00	FALSE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	C16orf75	0.13	0.07	lasso	8	0.13	6.8e-25	-2.49	5.6	1.9e-08	-0.05	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	DEXI	0.04	0.02	blup	49	0.04	8.6e-08	-19.95	-21.1	5.6e-99	0.66	0.03	0.96	FALSE
43	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C16orf75	0.10	0.05	lasso	6	0.08	2.2e-09	-4.23	5.7	1.2e-08	-0.04	0.99	0.00	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DEXI	0.05	0.02	lasso	4	0.03	1.7e-04	-19.57	-21.7	5.3e-104	0.64	0.02	0.84	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SOCS1	0.08	0.01	enet	7	0.03	8.4e-05	-1.29	10.5	1.2e-25	-0.32	0.03	0.07	FALSE
46	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C16orf75	0.14	0.01	blup	114	0.02	1.4e-02	7.71	5.8	5.5e-09	-0.10	0.04	0.72	FALSE
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	DEXI	0.09	0.01	blup	49	0.07	8.8e-08	12.46	-13.3	1.4e-40	0.54	0.02	0.87	FALSE
48	The Cancer Genome Atlas	Soft Tissue Sarcoma	C16orf75	0.11	0.02	blup	113	0.02	1.6e-02	-2.47	10.9	6.7e-28	-0.20	0.00	0.95	TRUE
49	The Cancer Genome Atlas	Skin Cutaneous Melanoma	DEXI	0.20	0.00	blup	49	0.06	1.3e-02	9.66	-9.9	3.5e-23	0.42	0.01	0.10	FALSE
50	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SOCS1	0.10	0.02	lasso	3	0.02	7.8e-02	-6.73	-11.8	3.1e-32	0.32	0.02	0.46	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	C16orf75	0.25	0.12	lasso	6	0.22	1.2e-20	0.31	-5.7	1.1e-08	0.13	1.00	0.00	TRUE
52	The Cancer Genome Atlas	Thyroid Carcinoma	CLEC16A	0.14	0.06	lasso	4	0.09	6.8e-09	-18.89	12.2	4.1e-34	-0.63	0.22	0.78	TRUE
53	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	C16orf75	0.25	0.05	blup	113	0.09	1.9e-03	-4.23	6.8	1.0e-11	-0.11	0.07	0.07	FALSE