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chr16:2,191,734-5,281,856

Best TWAS P=1.32e-36 · Best GWAS P=2.63e-38 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CORO7	0.08	0.08	lasso	2	0.06	4.3e-08	5.5	-5.5	3.1e-08	0.04	0.04	0.96	FALSE
2	GTEx	Adipose Subcutaneous	HMOX2	0.13	0.05	lasso	6	0.04	2.2e-04	5.0	5.6	2.3e-08	-0.01	0.03	0.97	FALSE
3	GTEx	Adipose Subcutaneous	NMRAL1	0.31	0.33	lasso	4	0.35	9.0e-30	5.2	5.4	5.4e-08	-0.01	0.09	0.91	FALSE
4	GTEx	Artery Aorta	NMRAL1	0.43	0.42	lasso	8	0.42	4.7e-25	5.2	5.2	1.5e-07	-0.01	0.08	0.92	FALSE
5	GTEx	Artery Coronary	NMRAL1	0.40	0.34	lasso	5	0.34	3.5e-12	5.5	5.6	2.2e-08	-0.01	0.04	0.96	FALSE
6	GTEx	Artery Tibial	CDIP1	0.14	0.14	lasso	3	0.16	1.0e-12	5.6	-5.8	7.4e-09	-0.01	0.02	0.98	FALSE
7	GTEx	Artery Tibial	NMRAL1	0.38	0.30	enet	15	0.36	1.2e-29	5.2	5.3	1.4e-07	0.00	0.05	0.95	FALSE
8	GTEx	Brain Cerebellar Hemisphere	CDIP1	0.47	0.47	lasso	6	0.52	1.2e-15	5.2	5.5	4.2e-08	-0.04	0.10	0.89	FALSE
9	GTEx	Brain Cerebellar Hemisphere	NMRAL1	0.62	0.66	lasso	3	0.68	2.2e-23	5.2	5.3	1.4e-07	-0.01	0.12	0.88	FALSE
10	GTEx	Brain Cerebellum	CDIP1	0.47	0.54	lasso	7	0.52	8.3e-18	5.2	5.6	1.7e-08	-0.01	0.08	0.92	FALSE
11	GTEx	Brain Cerebellum	NMRAL1	0.81	0.55	lasso	10	0.62	4.6e-23	5.1	5.5	3.5e-08	-0.02	0.03	0.96	FALSE
12	GTEx	Brain Nucleus accumbens basal ganglia	HMOX2	0.28	-0.01	lasso	5	-0.01	7.1e-01	5.1	-5.1	3.1e-07	0.02	0.05	0.45	FALSE
13	GTEx	Breast Mammary Tissue	NMRAL1	0.17	0.18	lasso	2	0.15	5.2e-08	5.2	5.2	2.2e-07	-0.01	0.09	0.91	FALSE
14	GTEx	Breast Mammary Tissue (Male)	NMRAL1	0.20	0.11	lasso	4	0.10	2.4e-03	5.6	5.4	6.4e-08	-0.01	0.04	0.60	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	CDIP1	0.16	0.10	lasso	7	0.06	6.8e-03	4.8	-5.5	4.7e-08	0.04	0.03	0.91	FALSE
16	GTEx	Cells Transformed fibroblasts	CDIP1	0.33	0.35	lasso	3	0.36	1.3e-28	5.6	-5.8	8.1e-09	-0.01	0.02	0.98	FALSE
17	GTEx	Cells Transformed fibroblasts	NMRAL1	0.15	0.12	lasso	5	0.12	1.6e-09	5.2	5.2	1.7e-07	-0.01	0.05	0.95	FALSE
18	GTEx	Colon Sigmoid	CDIP1	0.25	0.04	lasso	6	0.04	1.6e-02	5.3	-5.5	4.8e-08	0.01	0.04	0.63	FALSE
19	GTEx	Colon Sigmoid	NMRAL1	0.43	0.35	lasso	5	0.31	1.7e-11	5.2	5.3	1.3e-07	-0.01	0.11	0.89	FALSE
20	GTEx	Colon Transverse	CDIP1	0.21	0.07	lasso	4	0.09	4.5e-05	5.8	-5.9	3.7e-09	0.00	0.02	0.98	TRUE
21	GTEx	Esophagus Gastroesophageal Junction	CDIP1	0.25	0.24	lasso	5	0.25	1.2e-09	5.6	-5.9	3.7e-09	-0.01	0.03	0.97	FALSE
22	GTEx	Esophagus Mucosa	NMRAL1	0.23	0.13	lasso	4	0.12	2.7e-08	5.6	5.5	3.4e-08	-0.01	0.03	0.97	FALSE
23	GTEx	Esophagus Muscularis	CDIP1	0.35	0.16	lasso	11	0.20	3.9e-12	5.8	-5.6	2.7e-08	-0.02	0.01	0.99	FALSE
24	GTEx	Heart Atrial Appendage	NMRAL1	0.27	0.25	lasso	2	0.23	1.1e-10	5.2	5.2	2.0e-07	-0.01	0.12	0.88	FALSE
25	GTEx	Heart Left Ventricle	NMRAL1	0.36	0.26	enet	12	0.28	4.4e-15	5.6	5.7	1.6e-08	0.00	0.02	0.98	FALSE
26	GTEx	Lung	NMRAL1	0.16	0.11	enet	3	0.13	3.4e-10	5.2	5.3	8.7e-08	-0.01	0.08	0.92	FALSE
27	GTEx	Muscle Skeletal	CDIP1	0.07	0.07	lasso	2	0.06	6.1e-07	5.5	-5.5	5.0e-08	0.01	0.03	0.97	FALSE
28	GTEx	Muscle Skeletal	NMRAL1	0.27	0.22	enet	28	0.31	2.0e-30	5.6	5.4	7.4e-08	0.00	0.02	0.98	FALSE
29	GTEx	Nerve Tibial	CDIP1	0.20	0.12	lasso	5	0.13	1.4e-09	5.8	-5.6	2.2e-08	-0.01	0.01	0.99	FALSE
30	GTEx	Nerve Tibial	NMRAL1	0.32	0.37	lasso	3	0.36	5.2e-27	5.2	5.2	1.5e-07	-0.01	0.15	0.85	FALSE
31	GTEx	Pituitary	NMRAL1	0.31	0.18	enet	12	0.23	1.9e-06	5.1	5.6	1.7e-08	-0.02	0.08	0.88	FALSE
32	GTEx	Skin Not Sun Exposed Suprapubic	NMRAL1	0.19	0.12	lasso	3	0.11	1.3e-06	5.1	5.1	3.1e-07	0.00	0.16	0.84	FALSE
33	GTEx	Skin Sun Exposed Lower leg	CDIP1	0.08	0.06	lasso	3	0.05	6.8e-05	5.6	-5.5	3.2e-08	0.01	0.03	0.95	FALSE
34	GTEx	Testis	NMRAL1	0.27	0.20	enet	6	0.22	2.4e-10	5.6	5.8	6.7e-09	-0.02	0.04	0.96	FALSE
35	GTEx	Thyroid	CDIP1	0.15	0.14	lasso	3	0.15	1.5e-11	5.6	-5.8	5.5e-09	0.00	0.02	0.98	FALSE
36	GTEx	Thyroid	NMRAL1	0.18	0.14	lasso	3	0.15	2.4e-11	5.3	5.6	1.8e-08	0.01	0.03	0.97	FALSE
37	METSIM	Adipose	CDIP1	0.07	0.06	lasso	5	0.08	2.8e-12	5.7	-5.8	5.2e-09	0.01	0.01	0.99	FALSE
38	METSIM	Adipose	ZG16B	0.08	0.05	enet	23	0.05	6.7e-08	4.1	-5.6	2.1e-08	-0.31	1.00	0.00	FALSE
39	ROSMAP	Brain Pre-frontal Cortex	CDIP1	0.13	0.18	lasso	2	0.17	3.6e-21	5.5	5.7	1.5e-08	-0.02	0.03	0.97	FALSE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	C16orf5	0.02	0.03	blup	37	0.03	9.7e-08	5.1	-5.5	3.5e-08	0.03	0.06	0.94	FALSE
41	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNF500	0.11	0.01	blup	49	0.03	8.8e-05	3.4	-5.5	3.4e-08	0.06	0.00	0.00	TRUE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C16orf5	0.02	0.02	lasso	3	0.02	4.5e-03	5.6	-5.7	1.3e-08	0.00	0.01	0.95	FALSE
43	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NAT15	0.20	0.06	blup	56	0.08	9.0e-10	4.3	-5.7	1.6e-08	-0.05	0.03	0.97	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TCEB2	0.04	0.02	blup	29	0.02	1.7e-03	5.2	7.1	9.2e-13	0.57	0.08	0.31	FALSE
45	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C16orf5	0.09	0.10	lasso	2	0.06	1.6e-04	5.3	-5.3	1.1e-07	0.00	0.02	0.96	FALSE
46	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ZG16B	0.07	0.03	blup	35	0.05	4.5e-04	4.6	-6.3	3.9e-10	-0.41	0.05	0.15	FALSE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	HMOX2	0.02	0.03	lasso	2	0.02	3.9e-03	5.8	5.4	5.7e-08	0.02	0.01	0.97	FALSE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	NMRAL1	0.17	0.20	enet	14	0.21	3.3e-23	5.0	5.2	1.5e-07	0.02	0.07	0.93	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	PRSS33	0.13	0.10	lasso	4	0.10	6.5e-11	12.9	12.6	1.3e-36	0.98	0.00	1.00	TRUE
50	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ZG16B	0.28	0.25	blup	35	0.27	4.8e-13	4.3	-6.1	1.2e-09	-0.44	1.00	0.00	FALSE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	C16orf5	0.03	0.03	lasso	2	0.02	1.3e-03	5.5	-5.5	4.0e-08	0.01	0.03	0.92	FALSE
52	The Cancer Genome Atlas	Lung Adenocarcinoma	NAT15	0.06	0.04	blup	56	0.04	4.1e-05	5.5	-5.9	3.3e-09	-0.04	0.02	0.95	FALSE
53	The Cancer Genome Atlas	Lung Adenocarcinoma	ZG16B	0.12	0.19	blup	35	0.19	3.1e-21	4.2	-5.4	5.5e-08	-0.34	1.00	0.00	FALSE
54	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PRSS21	0.08	0.00	blup	45	0.03	5.6e-03	12.9	5.3	1.3e-07	0.45	0.00	0.25	FALSE
55	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NAT15	0.30	0.19	blup	56	0.20	1.2e-08	5.1	-5.7	1.3e-08	-0.02	0.16	0.83	FALSE
56	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ZG16B	0.14	0.14	blup	35	0.15	1.1e-06	4.6	-6.9	3.9e-12	-0.45	0.23	0.56	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	C16orf5	0.07	0.07	blup	37	0.07	1.1e-07	5.1	-5.7	1.3e-08	0.01	0.02	0.97	FALSE
58	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC342346	0.06	0.02	blup	34	0.02	1.2e-03	5.6	-5.6	2.7e-08	0.06	0.01	0.98	FALSE
59	The Cancer Genome Atlas	Rectum Adenocarcinoma	ZG16B	0.13	0.12	blup	35	0.12	1.0e-03	4.8	-6.0	2.7e-09	-0.40	0.06	0.17	FALSE
60	The Cancer Genome Atlas	Soft Tissue Sarcoma	NAT15	0.20	0.08	enet	14	0.17	1.8e-10	5.5	-6.8	9.7e-12	-0.02	0.02	0.98	TRUE
61	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ZG16B	0.23	0.07	enet	18	0.15	5.8e-06	4.3	-6.9	6.4e-12	-0.39	0.11	0.14	FALSE
62	The Cancer Genome Atlas	Thyroid Carcinoma	C16orf5	0.05	0.07	enet	4	0.07	1.1e-07	5.8	-5.8	7.0e-09	-0.01	0.01	0.99	FALSE
63	The Cancer Genome Atlas	Thyroid Carcinoma	ZG16B	0.10	0.15	enet	9	0.16	2.0e-15	4.9	-6.0	1.7e-09	-0.42	1.00	0.00	FALSE