Best TWAS P=2.61e-19 · Best GWAS P=9.21e-31 conditioned to 4.86e-25
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | C16orf74 | 0.15 | 0.14 | lasso | 2 | 0.13 | 1.4e-07 | -8.6 | -9.0 | 2.6e-19 | -0.05 | 0.93 | 0.00 | TRUE |
| 2 | GTEx | Esophagus Mucosa | EMC8 | 0.13 | 0.09 | lasso | 2 | 0.08 | 3.0e-06 | -6.4 | -6.9 | 5.8e-12 | -0.09 | 0.93 | 0.00 | FALSE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | COX4NB | 0.03 | 0.01 | blup | 45 | 0.02 | 2.3e-03 | -7.4 | -5.7 | 1.3e-08 | -0.08 | 0.03 | 0.42 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | IRF8 | 0.13 | 0.00 | blup | 130 | 0.04 | 2.3e-03 | -1.6 | 5.3 | 1.1e-07 | 0.18 | 0.03 | 0.04 | TRUE |