TWAS hub - IRF8

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.232	0.0636	2.2e-07	0.014	0.073	0.071	NA	0.025	0.0097	1.3e-08	2.2e-08	NA	0.00064
2	TCGA	Kidney Renal Papillary Cell Carcinoma	0.128	0.0600	3.8e-03	0.002	0.040	0.013	NA	0.004	0.2400	2.3e-03	5.4e-02	NA	0.17000

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Mouth/teeth dental problems: Mouth ulcers	14.2	22.6	34.1	-3.3	-5.8
Prospective memory result	8.6	10.5	11.1	3.3	3.2
Lupus	7.1	10.8	14.7	-2.6	-3.8
Ever had hysterectomy (womb removed)	6.8	7.7	10.0	3.2	2.3
Ever used hormone-replacement therapy (HRT)	4.7	6.0	7.0	2.2	2.6
Alcohol intake versus 10 years previously	4.2	6.3	7.6	2.2	2.8
Time employed in main current job	3.5	4.0	4.2	2.0	2.0
Supplements: Vitamin C	3.4	4.0	7.3	-0.8	-2.7
LDL Cholesterol	3.3	5.2	5.6	2.4	2.2
Qualifications: CSEs or equivalent	3.3	4.4	6.2	-1.6	2.5
Ulcerative Colitis	3.1	4.4	7.1	2.7	1.3
Diabetes (self-reported)	2.9	4.5	7.1	1.3	2.7
Ever highly irritable/argumentative for 2 days	2.9	3.4	4.1	1.6	2.0
Family relationship satisfaction	2.9	3.6	4.5	-2.1	-1.6
Loud music exposure frequency	2.8	3.1	4.3	1.3	2.1
Alzheimer’s Disease (in father)	2.7	2.9	3.0	1.7	1.7
Rheumatoid Arthritis	2.7	3.7	4.8	-1.6	-2.2
Coronary Artery Disease (CAD)	2.6	3.2	3.5	1.7	1.9
Medication: Allopurinol	2.5	3.3	5.8	-0.9	-2.4
Ulcerative Colitis (UC)	2.4	4.5	8.5	2.9	0.7
Vitamin and mineral supplements	2.4	3.2	4.4	1.4	2.1
Bilateral oophorectomy (both ovaries removed)	2.4	2.7	4.8	2.2	0.8
Townsend deprivation index at recruitment	2.2	3.1	5.4	2.3	0.9
Osteoporosis (self-reported)	2.2	2.8	5.1	2.3	0.7
Osteoarthritis (self-reported)	2.1	2.7	3.5	1.9	1.4
Bipolar Disorder (2018)	2.0	3.2	3.5	1.9	-1.7
Hearing difficulty/problems with background noise	2.0	3.2	3.3	-1.8	-1.7
Mouth/teeth dental problems	2.0	3.1	5.6	0.8	2.4
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	4.8	0.0	2.2
Had menopause	1.9	2.4	3.9	2.0	0.9
Ever had bowel cancer screening	1.9	2.3	2.9	1.7	1.3
Bipolar Disorder or Schizophrenia	1.8	4.5	5.3	2.3	-1.9
Blood Eosinophil Count	1.8	14.2	28.3	0.3	5.3
Average weekly spirits intake	1.8	2.3	2.3	1.5	1.5
Medication: Ventolin 100micrograms inhaler	1.8	2.2	2.8	-1.3	-1.7
Age started oral contraceptive pill	1.8	2.2	4.5	0.2	-2.1
Diabetes (father)	1.7	2.1	2.1	1.4	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	4.4	2.1	0.0
Wears glasses or contact lenses	1.7	1.9	3.8	1.9	0.3
Myopia	1.7	2.5	3.5	1.9	1.2
Illnesses of mother	1.6	2.0	3.9	-0.5	-2.0
Long-standing illness, disability or infirmity	1.6	2.5	4.0	-1.0	-2.0
Pain type(s) experienced in last month: Hip pain	1.6	2.0	2.4	-1.3	-1.5
Alzheimer’s Disease (including proxy)	1.5	2.2	2.5	1.4	1.6
Taking other prescription medications	1.5	2.4	2.8	-1.4	-1.7
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	2.7	0.6	1.6
Financial situation satisfaction	1.4	1.7	2.7	-1.6	-0.8
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	3.4	0.3	-1.9
Type 2 Diabetes (T2D) (2018)	1.3	2.5	4.7	0.6	2.2
Maternal smoking around birth	1.3	1.9	2.4	1.2	1.5
Serious illness, injury or assault to yourself	1.3	1.5	3.0	1.7	0.2
Mouth/teeth dental problems: Loose teeth	1.3	1.5	2.9	0.4	1.7
Primary Biliary Cirrhosis	1.2	1.8	2.9	-0.8	-1.7
High blood pressure (mother)	1.2	1.6	2.5	-1.6	0.9
Alcohol usually taken with meals	1.2	2.0	4.0	-0.1	-2.0
Blood clot in the leg (DVT)	1.2	1.5	2.3	0.9	-1.5
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	3.3	-1.8	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	1.9	-0.9	1.4
Tinnitus: Yes, now most or all of the time	1.2	1.3	2.6	1.6	-0.4
Eye problems/disorders: Glaucoma	1.2	1.4	2.5	-0.5	-1.6
Age at First Birth	1.1	1.5	1.8	1.4	1.1
Schizophrenia (2014)	1.1	2.5	2.6	1.6	-1.6
Medication: Levothyroxine sodium	1.1	1.9	2.7	-1.6	-1.0
Heart attack	1.1	1.4	2.6	1.6	0.5
Age at first live birth	1.1	1.9	3.3	-0.8	-1.8
Medication: Omeprazole	1.1	1.3	2.5	-0.1	-1.6
Commuting to job workplace: Car/motor vehicle	1.1	1.2	1.5	1.0	1.2
Diabetes diagnosed by doctor	1.1	1.9	3.0	0.8	1.7
Neuroticism (Nagel 2018)	1.0	2.3	4.0	2.0	-0.8
Major Depression (MDD)	1.0	1.2	2.2	1.5	0.4
Fed-up feelings	1.0	1.9	3.5	1.9	0.5
Multivitamins +/- minerals	1.0	1.2	1.3	-1.1	-1.1
Happiness	1.0	1.2	1.9	-1.4	-0.7
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	2.2	1.5	1.1
Exposure to tobacco smoke outside home	1.0	1.3	2.6	1.6	0.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.4	-1.6	0.1
Qualifications: nursing, teaching	1.0	1.6	2.9	0.6	1.7
Schizophrenia (2018)	0.9	1.8	2.5	1.6	-1.1
Crohns Disease (2012)	0.9	1.4	1.6	-1.3	-1.1
Blood White Count	0.9	6.7	11.6	-3.4	1.3
Current tobacco smoking	0.9	1.5	2.7	0.5	1.6
Medication: Lansoprazole	0.9	1.1	1.9	-0.5	-1.4
Hair/balding pattern: Pattern 4	0.9	2.2	2.7	1.6	1.3
Health satisfaction	0.9	1.2	1.6	-1.3	-0.9
Number of full sisters	0.9	1.0	1.3	0.9	1.1
Supplements: Calcium	0.9	1.0	1.9	-1.4	-0.3
Depressed Affect (Nagel 2018)	0.8	1.6	3.3	1.8	-0.1
Reaction Time	0.8	1.5	1.8	-1.4	1.0
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.6	1.3	-0.0
Pulse rate	0.8	1.3	1.4	-1.1	-1.2
Glaucoma (self-reported)	0.8	0.9	1.7	-0.4	-1.3
Medication: Blood pressure	0.8	1.4	1.9	-1.0	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.8	1.3	-0.2
Breast cancer (self-reported)	0.8	1.0	1.0	-1.0	-1.0
Number of self-reported non-cancer illnesses	0.8	1.5	1.8	1.4	-1.1
Ever taken oral contraceptive pill	0.8	0.8	1.3	0.6	1.1
Irritability	0.8	1.4	2.7	0.2	-1.6
Risk taking	0.8	1.1	2.1	0.4	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.8	-0.3	-1.4
Pain experienced in last month	0.8	1.3	2.5	1.6	0.4
Heart attack/myocardial infarction (self-reported)	0.8	1.1	1.9	1.4	0.5
Schizophrenia vs Biploar Disorder	0.7	1.0	1.0	1.0	1.0
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.5	0.4	1.2
Severe depression (siblings)	0.7	0.8	1.6	-1.3	0.3
Neuroticism score	0.7	1.4	2.2	1.5	-0.8
Hair/balding pattern: Pattern 3	0.7	1.0	1.9	-0.1	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.5	0.8	1.2
Gout (self-reported)	0.7	0.9	1.9	-0.0	-1.4
High blood pressure (siblings)	0.7	1.0	1.7	0.7	1.3
Leg pain on walking	0.7	0.9	0.9	-1.0	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.4	-1.2	-0.4
Guilty feelings	0.7	1.1	2.1	0.3	-1.5
Medication: Bendroflumethiazide	0.7	1.1	2.2	0.1	-1.5
Heart disease (siblings)	0.7	0.8	1.6	1.3	-0.3
Sensitivity / hurt feelings	0.6	1.0	2.0	1.4	-0.1
Stomach or abdominal pain in last month	0.6	0.7	1.2	-1.1	-0.4
Supplements: Glucosamine	0.6	0.7	1.4	-1.2	-0.3
Medication: Atenolol	0.6	0.7	1.2	-0.5	-1.1
Worrier / anxious feelings	0.6	1.1	2.0	1.4	0.4
Falls in the last year	0.6	0.8	1.6	-0.3	-1.2
Noisy workplace	0.6	0.8	0.9	0.9	-0.8
Breastfed as a baby	0.6	0.7	1.3	0.3	-1.1
Tense / ‘highly strung’	0.6	0.9	1.8	1.4	0.0
Comparative body size at age 10	0.6	1.8	2.8	-0.9	-1.7
Worry too long after embarrassment	0.6	1.0	1.9	1.4	-0.3
Qualifications: College or University degree	0.6	2.0	3.9	-0.1	-2.0
Angina (self-reported)	0.6	0.7	1.4	-0.2	-1.2
Comparative height size at age 10	0.6	3.1	4.0	-2.0	-1.5
Eye problems/disorders: Cataract	0.6	0.6	1.1	-0.4	1.0
Alcohol drinker status: Never	0.6	0.7	1.4	1.2	-0.2
Number of operations (self-reported)	0.6	0.9	1.0	1.0	0.9
Cholesterol lowering medication	0.6	0.9	1.8	0.3	1.3
Basal cell carcinoma (self-reported)	0.6	0.8	1.5	1.2	0.2
Fasting Glucose	0.5	0.6	0.8	-0.7	-0.9
Neuroticism (2016)	0.5	0.7	1.3	1.1	0.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	0.7	0.8	-0.9
Hearing difficulty/problems: Yes	0.5	0.7	1.4	1.2	-0.2
Medication for hormone replacement therapy	0.5	0.6	1.2	0.2	1.1
Medication: Metformin	0.5	0.8	1.5	-0.1	1.2
Diabetes (mother)	0.5	0.6	1.1	1.0	0.4
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.1	-1.0	1.0
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.1	-0.1	-1.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	0.9	-1.0	-0.6
Mouth/teeth dental problems: Dentures	0.5	0.9	1.1	1.1	-0.8
Medication: Cholesterol lowering	0.5	0.8	0.9	-1.0	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	3.0	-1.7	-0.2
Medication: Paracetamol	0.5	0.8	1.1	-0.7	-1.1
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.0	0.4	1.0
Neck or shoulder pain in last month	0.5	0.7	1.4	-0.0	-1.2
Heart disease (mother)	0.5	0.6	0.9	0.6	0.9
Alcohol intake frequency.	0.5	1.1	2.2	0.0	1.5
Chest pain or discomfort	0.5	0.7	0.9	0.9	0.7
Age at last live birth	0.5	0.8	1.1	1.1	-0.7
Knee pain experienced in last month	0.5	0.8	1.3	-0.6	-1.1
Mood swings	0.5	0.9	1.6	1.3	-0.4
Loneliness, isolation	0.5	0.8	0.9	1.0	-0.8
Commuting to job workplace: Walk	0.5	0.6	0.9	-1.0	-0.5
Back pain experienced in last month	0.5	0.7	1.3	-1.1	0.4
Mineral and other dietary supplements	0.5	0.7	1.2	1.1	0.5
Asthma (self-reported)	0.5	0.9	1.2	1.1	0.8
Smoking status: Current	0.5	0.8	1.3	0.6	1.1
Mother’s age at death	0.5	0.6	0.7	-0.8	-0.7
Alcohol drinker status: Previous	0.5	0.6	1.1	0.1	1.1
Depression (Nagel 2018)	0.4	0.6	0.7	0.7	-0.8
Worry (Nagel 2018)	0.4	0.9	1.6	0.3	-1.3
Irritable Bowel Disease (IBD)	0.4	0.8	1.5	1.2	0.4
HbA1C	0.4	0.4	0.8	0.9	0.2
Triglycerides	0.4	0.7	0.7	-0.8	0.9
Cardiovascular Disease	0.4	1.5	2.7	-1.6	-0.5
Hypothyroidism (self reported)	0.4	1.0	1.7	-1.3	-0.4
Neuroticism	0.4	1.0	2.0	1.4	-0.2
Chronotype (morning person)	0.4	0.9	1.8	0.1	1.4
Number of treatments/medications taken	0.4	0.8	1.0	-0.8	-1.0
Angina	0.4	0.5	1.0	-0.0	-1.0
Supplements: Zinc	0.4	0.5	0.7	-0.8	-0.5
Chronic bronchitis/emphysema (father)	0.4	0.4	0.8	0.9	0.2
Nervous feelings	0.4	0.7	1.0	0.6	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.2	1.1	-0.0
Had other major operations	0.4	0.4	0.9	0.1	0.9
Forced vital capacity (FVC)	0.4	1.5	2.9	-1.7	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.2	-1.1	-0.8
Fluid intelligence score	0.4	0.9	1.5	-1.2	0.4
Asthma	0.4	0.8	1.0	1.0	0.8
Pulse wave Arterial Stiffness index	0.4	0.5	0.9	-0.1	-1.0
Length of working week for main job	0.4	0.4	0.5	0.5	0.7
Birth weight of first child	0.4	0.8	1.6	-0.1	1.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	0.8	0.5	0.9
Pulse wave peak to peak time	0.4	0.5	1.0	0.1	1.0
Shortness of breath walking on level ground	0.4	0.5	0.8	0.9	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.3	-1.1	0.6
Miserableness	0.4	0.6	1.1	0.4	-1.1
Medication: Paracetamol	0.4	0.7	0.7	-0.8	-0.9
Average weekly beer plus cider intake	0.4	0.6	1.1	0.3	-1.0
Alzheimer’s Disease (in mother)	0.3	0.3	0.6	0.1	0.8
Breast Cancer	0.3	0.8	0.9	0.9	0.9
Bipolar Disorder (2011)	0.3	0.3	0.5	-0.3	-0.7
Body Mass Index (BMI) (2010)	0.3	0.4	0.4	-0.5	-0.7
HDL Cholesterol	0.3	0.6	0.7	0.7	-0.8
Blood Red Count	0.3	2.6	2.6	-1.6	1.6
Tanning	0.3	3.6	5.2	1.4	2.3
Medication: Co-codamol	0.3	0.4	0.7	0.8	-0.2
Hand grip strength (right)	0.3	0.8	0.9	-0.9	-0.9
Relative age voice broke	0.3	0.5	0.5	0.7	-0.7
Age when periods started (menarche)	0.3	0.7	0.9	-0.7	-1.0
Qualifications: None of the above	0.3	0.6	1.0	0.3	-1.0
Medication: Ramipril	0.3	0.4	0.6	0.4	-0.8
Illnesses of siblings	0.3	0.5	0.5	-0.7	-0.7
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.2	-1.5	0.2
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.0	-0.5	-1.0
Depression (self-reported)	0.3	0.4	0.6	0.8	0.3
Pulse wave reflection index	0.3	0.4	0.7	0.8	0.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.5	0.7	0.6
Birth weight	0.3	0.6	1.2	0.0	1.1
Forced vital capacity (FVC), Best measure	0.3	1.1	1.7	-1.3	-0.7
Leg fat percentage (right)	0.3	0.9	1.9	-0.2	-1.4
Emphysema/chronic bronchitis	0.3	0.3	0.6	0.7	0.3
Medication for pain relief, constipation, heartburn	0.3	0.5	0.8	0.9	0.5
Mean time to correctly identify matches	0.3	0.6	1.0	-0.3	1.0
Suffer from ‘nerves’	0.3	0.5	0.8	-0.4	-0.9
Smoking status: Previous	0.3	0.4	0.7	-0.3	-0.8
Average weekly red wine intake	0.3	0.4	0.7	0.4	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	0.8	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.4	-1.2	-0.0
Average weekly champagne plus white wine intake	0.3	0.4	0.8	0.9	-0.3
Hearing aid user	0.3	0.3	0.5	0.3	0.7
Medication: Blood pressure	0.3	0.5	0.7	0.5	-0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.5	-0.4	0.7
Leg fat percentage (left)	0.3	1.2	2.2	-0.4	-1.5
Diastolic blood pressure, automated reading	0.3	1.0	1.7	-1.3	-0.5
Leg fat mass (left)	0.3	1.0	2.0	0.1	-1.4
Verbal and Numeric Reasoning (VNR)	0.2	0.6	0.9	-0.9	0.4
Ovarian Cancer	0.2	0.2	0.4	0.3	0.6
Prostate Cancer	0.2	0.2	0.3	0.6	-0.4
Mean Putamen Volume	0.2	0.3	0.4	-0.6	0.4
Systolic Blood Pressure	0.2	0.8	1.4	-1.2	-0.5
Allergy or Eczema	0.2	0.5	0.7	-0.6	0.8
Respiratory disease	0.2	0.4	0.5	0.7	0.5
Lung FEV1/FVC ratio	0.2	0.8	0.8	-0.9	0.9
Lung FVC	0.2	0.8	0.9	-0.9	-0.9
Relative age of first facial hair	0.2	0.5	0.8	0.9	-0.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.3	-0.3	-0.6
Systolic blood pressure, automated reading	0.2	0.5	0.6	-0.7	-0.8
Impedance of leg (right)	0.2	0.8	1.6	-1.2	-0.3
Trunk fat percentage	0.2	0.7	1.3	-0.0	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.2	0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.7	-0.1	-0.8
Impedance of leg (left)	0.2	1.2	2.0	-1.4	-0.5
Trunk fat mass	0.2	0.8	1.5	-0.1	-1.2
Hair/balding pattern: Pattern 2	0.2	0.3	0.3	-0.6	-0.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	0.3	0.6
Father’s age at death	0.2	0.3	0.6	-0.2	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.3	0.6	-0.5
Number of live births	0.2	0.3	0.4	0.7	0.3
Lung cancer (father)	0.2	0.2	0.3	0.4	-0.5
Exposure to tobacco smoke at home	0.2	0.2	0.3	0.5	-0.3
Medication: Amlodipine	0.2	0.3	0.5	0.2	-0.7
Body fat percentage	0.2	0.9	1.8	-0.3	-1.3
Number of full brothers	0.2	0.2	0.3	0.5	-0.5
Number of children fathered	0.2	0.2	0.2	-0.5	-0.3
Whole body fat mass	0.2	0.9	1.8	0.1	-1.3
Leg fat mass (right)	0.2	0.8	1.5	0.3	-1.2
Overall health rating	0.2	0.3	0.6	-0.3	-0.8
Had major operations	0.2	0.2	0.4	0.2	0.6
Medication: Aspirin	0.2	0.3	0.3	-0.5	0.6
Illnesses of father: Heart disease	0.2	0.2	0.4	0.6	-0.2
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	-0.6	0.3
Illnesses of father: None of the above (group 1)	0.2	0.3	0.4	-0.3	-0.7
Commuting to job workplace: Public transport	0.2	0.2	0.5	0.0	-0.7
High cholesterol (Self-reported)	0.2	0.4	0.6	-0.8	0.4
Medication: Lisinopril	0.2	0.2	0.5	0.7	-0.1
Fractured/broken bones in last 5 years	0.2	0.3	0.5	0.2	-0.7
Ever depressed for a whole week	0.2	0.2	0.3	-0.5	0.3
Commuting to job workplace: Cycle	0.2	0.3	0.3	-0.5	-0.5
Impedance of whole body	0.2	1.1	1.9	-1.4	-0.4
Crohns Disease (2017)	0.1	0.2	0.4	-0.6	-0.0
Blood Platelet Count	0.1	1.3	2.0	0.7	-1.4
Waist Hip Ratio (WHR)	0.1	0.3	0.4	0.7	-0.5
Smoking Status	0.1	0.2	0.2	0.4	0.4
Hand grip strength (left)	0.1	0.3	0.3	-0.6	-0.4
Pack years adult smoking proportion	0.1	0.2	0.4	0.6	-0.1
Average weekly fortified wine intake	0.1	0.1	0.1	0.4	-0.3
High blood pressure	0.1	0.3	0.6	0.2	-0.8
Body mass index (BMI)	0.1	0.5	0.7	0.8	-0.6
Waist circumference	0.1	0.4	0.6	0.4	-0.8
Number of incorrect matches in round	0.1	0.2	0.3	0.6	0.1
Past tobacco smoking	0.1	0.2	0.3	0.3	0.5
Allergy	0.1	0.1	0.1	0.3	-0.4
Pain all over the body in last month	0.1	0.1	0.2	-0.0	0.5
Weight	0.1	0.3	0.5	0.1	-0.7
Impedance of arm (right)	0.1	0.5	1.0	-1.0	0.2
Arm fat percentage (right)	0.1	0.2	0.4	0.1	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.1	-0.3	-0.3
Impedance of arm (left)	0.1	0.6	1.1	-1.1	-0.1
Arm fat mass (right)	0.1	0.4	0.6	0.4	-0.8
Standing height	0.1	0.9	1.7	-1.3	-0.3
Peak expiratory flow (PEF)	0.1	0.2	0.3	-0.3	0.6
Headache pain in last month	0.1	0.2	0.3	-0.6	-0.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	0.7	0.1
Eye problems/disorders: None of the above	0.1	0.1	0.1	0.4	0.4
Migraine (self-reported)	0.1	0.1	0.1	0.3	0.3
Pulse rate, automated reading	0.1	0.2	0.2	0.4	0.4
Hypertension (Self-reported)	0.1	0.3	0.5	0.1	-0.7
Arm fat percentage (left)	0.1	0.4	0.8	0.0	-0.9
Friendships satisfaction	0.1	0.1	0.2	-0.4	0.1
Medication: Aspirin	0.1	0.1	0.2	-0.2	0.5
Medication: Gliclazide	0.1	0.1	0.1	0.2	0.3
Arm fat mass (left)	0.1	0.5	0.8	0.4	-0.9
Medication: Atorvastatin	0.1	0.1	0.2	-0.3	0.4
Ever smoked	0.1	0.2	0.3	-0.2	0.6
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	0.4	-0.3
Unable to work because of sickness or disability	0.1	0.1	0.1	0.3	0.3
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.6	0.1	0.8
Pack years of smoking	0.1	0.1	0.2	0.4	-0.3
Intelligence (Savage-Jansen 2018)	0.0	0.0	0.0	0.1	0.0
Heel T-Score	0.0	0.2	0.2	0.5	-0.3
BMI	0.0	0.2	0.4	0.0	-0.6
Height	0.0	0.2	0.5	-0.7	-0.1
Hair Pigment	0.0	1.2	2.4	-0.1	-1.5
Leg fat-free mass (left)	0.0	0.1	0.1	0.3	-0.4
Sitting height	0.0	0.1	0.1	-0.3	0.2
Leg predicted mass (left)	0.0	0.1	0.1	0.3	-0.3
Financial difficulties in last 2 years	0.0	0.0	0.1	0.0	-0.3
Medication: Simvastatin	0.0	0.1	0.1	0.4	-0.1
Trunk fat-free mass	0.0	0.0	0.1	0.2	-0.0
Hip circumference	0.0	0.1	0.1	-0.2	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.1	-0.3	0.0
Trunk predicted mass	0.0	0.0	0.0	0.2	-0.1
Arm fat-free mass (right)	0.0	0.1	0.1	0.3	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	-0.1	-0.2
Medication: Ibuprofen	0.0	0.0	0.0	0.1	0.1
Medication: Seretide 50 evohaler	0.0	0.0	0.1	-0.2	0.2
Arm predicted mass (right)	0.0	0.1	0.2	0.4	-0.3
Illnesses of siblings: Diabetes	0.0	0.0	0.0	0.1	0.2
Whole body fat-free mass	0.0	0.1	0.1	0.2	-0.3
Leg fat-free mass (right)	0.0	0.1	0.1	0.2	-0.3
Medication for cholesterol	0.0	0.0	0.1	0.3	-0.1
Whole body water mass	0.0	0.0	0.1	0.3	-0.1
Leg predicted mass (right)	0.0	0.1	0.1	0.2	-0.4
Illnesses of father: High blood pressure	0.0	0.0	0.0	0.0	-0.2
Basal metabolic rate	0.0	0.1	0.2	0.2	-0.4
Arm fat-free mass (left)	0.0	0.2	0.2	0.4	-0.5
Arm predicted mass (left)	0.0	0.2	0.4	0.6	-0.2

Hub : Genes

IRF8

Models

Trait associations