Hub : Genes

EMC8

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Mucosa 0.134 0.0490 0.0055 0.095 NA 0.076 NA 0.084 6.8e-07 NA 8.2e-06 NA 3.0e-06
2 GTEx Nerve Tibial 0.181 0.0579 0.0036 0.109 NA 0.054 NA 0.073 4.1e-08 NA 1.0e-04 NA 7.7e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.5 2.4 2.9 1.4 1.7
Bipolar Disorder or Schizophrenia 1.0 2.5 2.6 1.6 1.5
Depressed Affect (Nagel 2018) 0.2 0.4 0.8 -0.9 -0.2
Depression (Nagel 2018) 1.4 2.1 3.9 -2.0 0.5
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.2 0.3 -1.1
Neuroticism (Nagel 2018) 0.2 0.4 0.4 -0.6 -0.6
Schizophrenia (2018) 0.3 0.7 0.9 1.0 0.7
Schizophrenia vs Biploar Disorder 0.4 0.5 0.9 0.1 -1.0
Worry (Nagel 2018) 0.2 0.4 0.4 -0.7 -0.6
Alzheimer’s Disease (in mother) 0.8 1.0 2.0 -1.4 -0.0
Alzheimer’s Disease (in father) 0.9 1.0 1.1 -1.1 -1.0
Alzheimer’s Disease (including proxy) 1.4 2.1 3.3 -1.8 -0.9
Crohns Disease (2017) 0.2 0.4 0.7 0.3 -0.8
Irritable Bowel Disease (IBD) 0.5 1.2 2.3 0.2 -1.5
Ulcerative Colitis (UC) 0.5 1.0 1.9 0.1 -1.4
Major Depression (MDD) 0.8 0.9 1.8 1.4 0.0
Reaction Time 0.6 1.1 2.2 -1.5 0.1
Verbal and Numeric Reasoning (VNR) 0.5 1.3 2.2 -0.6 -1.5
Breast Cancer 1.1 2.7 4.6 -2.1 0.8
Ovarian Cancer 0.3 0.4 0.5 -0.5 0.7
Prostate Cancer 0.0 0.1 0.1 -0.1 -0.3
Age at First Birth 0.1 0.1 0.2 -0.4 -0.3
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.7 1.4 -1.2 -0.2
Coronary Artery Disease (CAD) 4.0 4.7 4.8 2.2 2.2
Crohns Disease (2012) 0.7 1.1 1.8 1.3 0.6
Mean Putamen Volume 0.2 0.3 0.4 0.4 0.6
Fasting Glucose 2.1 2.5 3.9 -2.0 -1.1
HbA1C 1.2 1.3 1.5 -1.1 -1.2
HDL Cholesterol 0.3 0.5 0.9 -1.0 -0.3
LDL Cholesterol 0.1 0.2 0.4 0.7 0.2
Lupus 2.1 3.2 6.0 2.5 -0.7
Neuroticism (2016) 0.2 0.3 0.5 -0.7 0.1
Primary Biliary Cirrhosis 1.0 1.4 1.5 1.2 -1.1
Rheumatoid Arthritis 0.6 0.9 1.7 1.3 -0.0
Schizophrenia (2014) 1.1 2.3 4.1 2.0 0.7
Triglycerides 0.2 0.4 0.8 0.2 0.9
Type 2 Diabetes (T2D) (2012) 2.6 3.0 4.8 1.1 2.2
Ulcerative Colitis 0.7 1.0 1.5 -0.7 -1.2
Blood Eosinophil Count 3.2 24.5 47.3 -6.9 1.3
Blood Platelet Count 0.3 3.5 5.1 -2.2 -1.4
Blood Red Count 0.0 0.1 0.1 0.2 -0.3
Blood White Count 1.6 12.0 23.9 0.3 4.9
Heel T-Score 0.0 0.2 0.3 -0.3 -0.5
BMI 0.0 0.2 0.3 -0.6 0.1
Height 0.0 0.2 0.3 0.4 0.5
Waist Hip Ratio (WHR) 0.4 1.8 2.3 -1.1 -1.5
Systolic Blood Pressure 0.1 0.4 0.7 -0.3 0.8
Smoking Status 0.4 0.8 1.6 1.3 -0.2
Allergy or Eczema 0.6 1.7 2.5 -1.6 0.9
Cardiovascular Disease 0.3 1.0 1.6 -1.2 -0.6
Hypothyroidism (self reported) 0.3 0.8 1.0 -0.7 -1.0
Respiratory disease 1.0 2.3 3.4 -1.8 1.1
Type 2 Diabetes (T2D) (2018) 1.2 2.3 4.6 -0.2 2.1
Lung FEV1/FVC ratio 0.2 0.9 1.8 0.2 1.3
Lung FVC 0.0 0.2 0.5 -0.1 -0.7
Neuroticism 0.3 0.7 1.3 -1.1 0.3
Chronotype (morning person) 0.2 0.5 0.8 0.9 0.3
Hair Pigment 0.0 0.0 0.1 -0.0 -0.3
Tanning 0.1 1.2 2.1 -1.4 0.6
Hand grip strength (left) 0.2 0.6 1.2 1.1 -0.0
Number of treatments/medications taken 0.5 0.9 1.2 -1.1 -0.7
Average weekly spirits intake 1.2 1.4 2.8 -1.7 -0.3
Sensitivity / hurt feelings 0.5 0.9 1.7 -1.3 -0.3
Frequency of depressed mood in last 2 weeks 0.4 0.6 1.1 -1.1 0.0
Hearing difficulty/problems: Yes 0.5 0.8 1.4 0.3 1.2
Relative age of first facial hair 0.0 0.0 0.0 0.2 -0.2
Other serious medical condition/disability diagnosed by doctor 2.9 3.7 6.8 -2.6 -0.8
Ever used hormone-replacement therapy (HRT) 2.5 3.2 4.8 2.2 1.3
Ever had hysterectomy (womb removed) 0.1 0.1 0.2 0.2 0.4
Systolic blood pressure, automated reading 0.5 1.4 2.5 -1.6 0.5
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 0.7 0.8 0.5
Angina 1.0 1.3 2.3 -1.5 -0.5
Medication for hormone replacement therapy 0.5 0.6 0.9 0.4 1.0
Vitamin and mineral supplements 0.4 0.5 1.0 -0.1 -1.0
Supplements: Zinc 0.1 0.1 0.1 0.3 -0.2
Medication: Co-codamol 0.2 0.2 0.3 -0.5 -0.5
Medication: Metformin 0.2 0.3 0.4 -0.7 0.4
Diabetes (father) 0.0 0.0 0.1 0.1 0.3
Diabetes (mother) 0.5 0.7 1.4 -1.2 -0.1
Severe depression (siblings) 1.6 1.7 2.0 1.4 1.2
Pack years adult smoking proportion 0.6 0.9 0.9 0.9 0.9
Impedance of leg (right) 0.0 0.0 0.0 -0.2 -0.0
Leg fat-free mass (left) 0.0 0.2 0.3 -0.2 0.5
Trunk fat percentage 0.1 0.5 0.9 -1.0 0.0
Hand grip strength (right) 0.0 0.1 0.1 0.4 -0.1
Townsend deprivation index at recruitment 0.5 0.6 1.1 -1.1 -0.4
Current tobacco smoking 1.2 1.9 3.1 0.9 1.8
Average weekly fortified wine intake 0.2 0.3 0.4 -0.4 -0.6
Maternal smoking around birth 2.4 3.5 4.7 2.2 1.5
Fed-up feelings 1.9 3.5 5.8 -2.4 -1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.9 3.7 -1.9 -0.3
Relative age voice broke 0.6 0.9 1.8 1.3 0.1
Taking other prescription medications 1.2 1.8 3.1 -1.8 -0.8
Age when periods started (menarche) 0.3 0.8 1.0 -1.0 -0.8
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.4 0.6 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.2 -0.4 -0.4
Tinnitus: Yes, but not now, but have in the past 1.7 1.8 2.4 1.1 1.5
Qualifications: CSEs or equivalent 0.7 0.9 1.6 -0.4 1.3
Serious illness, injury or assault to yourself 0.1 0.1 0.2 -0.4 -0.0
High blood pressure 0.7 2.0 3.9 -2.0 -0.1
Hayfever, allergic rhinitis or eczema 0.9 1.9 3.9 -2.0 0.1
Multivitamins +/- minerals 0.1 0.2 0.3 -0.6 0.1
Stomach or abdominal pain in last month 2.4 3.0 5.4 -0.8 2.3
Supplements: Glucosamine 0.0 0.0 0.0 0.2 -0.1
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 2.4 1.6 -0.6
Medication: Atenolol 0.1 0.1 0.2 -0.2 0.4
Medication: Levothyroxine sodium 0.6 1.0 2.0 -1.4 -0.0
Sitting height 0.1 0.6 1.0 -1.0 0.4
Chronic bronchitis/emphysema (father) 1.2 1.4 2.9 -0.0 -1.7
High blood pressure (mother) 0.0 0.1 0.1 -0.3 0.1
Body mass index (BMI) 0.1 0.3 0.5 -0.7 0.3
Impedance of leg (left) 0.0 0.1 0.3 0.0 0.5
Leg predicted mass (left) 0.0 0.2 0.3 -0.2 0.5
Trunk fat mass 0.1 0.5 1.0 -1.0 0.2
Waist circumference 0.1 0.4 0.4 -0.6 0.6
Number of incorrect matches in round 1.4 2.4 4.6 -0.4 -2.1
Past tobacco smoking 0.5 0.9 1.7 0.2 1.3
Alcohol usually taken with meals 0.9 1.5 2.4 1.6 0.8
Nervous feelings 0.0 0.0 0.0 0.1 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 1.0 -1.0 -0.9
Hearing difficulty/problems with background noise 0.0 0.0 0.0 -0.2 -0.2
Hair/balding pattern: Pattern 2 0.0 0.0 0.1 0.3 0.1
Had menopause 1.3 1.6 2.1 1.4 1.0
Had other major operations 0.6 0.7 1.4 -1.2 0.1
Forced vital capacity (FVC) 0.0 0.0 0.0 0.2 0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.0 0.0 -0.2 0.2
Ever unenthusiastic/disinterested for a whole week 0.9 1.0 1.3 0.9 1.1
Qualifications: None of the above 0.1 0.1 0.2 -0.4 -0.2
Financial difficulties in last 2 years 0.5 0.6 0.9 -0.7 0.9
Mouth/teeth dental problems 0.4 0.6 1.2 1.1 0.4
Heart attack 0.6 0.8 1.3 -1.1 -0.4
Allergy 1.1 2.6 5.1 2.3 0.2
Pain all over the body in last month 0.1 0.1 0.1 0.1 -0.3
Diabetes (self-reported) 0.3 0.5 0.9 -0.4 0.9
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.0 -1.0 -0.6
Medication: Ramipril 0.6 0.8 1.6 -1.3 0.1
Medication: Simvastatin 0.7 1.1 2.1 -1.4 -0.3
Fluid intelligence score 0.3 0.5 1.0 -0.2 -1.0
Illnesses of siblings 0.1 0.2 0.3 0.5 -0.3
Neuroticism score 0.7 1.4 2.5 -1.6 -0.5
Weight 0.1 0.4 0.4 -0.6 0.6
Impedance of arm (right) 0.1 0.5 0.8 0.5 -0.9
Arm fat percentage (right) 0.1 0.2 0.4 -0.7 -0.0
Trunk fat-free mass 0.2 1.2 2.3 0.0 1.5
Hip circumference 0.2 0.7 1.3 0.0 1.2
Time employed in main current job 1.0 1.1 2.2 -1.5 -0.4
Alcohol intake versus 10 years previously 0.1 0.2 0.3 0.6 0.3
Father’s age at death 1.1 1.5 2.9 0.5 -1.7
Worrier / anxious feelings 0.9 1.7 2.6 -1.6 -0.9
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.2 -0.1 1.1
Falls in the last year 0.5 0.6 1.2 -1.1 -0.2
Hair/balding pattern: Pattern 3 1.4 2.0 2.1 -1.4 -1.4
Number of live births 0.4 0.6 1.2 1.1 0.3
Forced expiratory volume in 1-second (FEV1) 0.0 0.2 0.3 -0.2 0.5
Pulse rate 0.6 1.0 2.0 1.4 -0.1
Happiness 0.1 0.1 0.1 0.3 -0.4
Noisy workplace 0.1 0.1 0.1 0.1 0.3
Qualifications: A levels/AS levels or equivalent 0.2 0.4 0.5 0.4 -0.7
Serious illness, injury or assault of a close relative in last 2 years 2.0 2.3 2.4 -1.4 -1.6
Mouth/teeth dental problems: Dentures 1.3 2.1 3.9 -2.0 -0.7
Asthma 0.7 1.4 2.0 -0.9 1.4
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 1.4 -1.2 -1.1
Medication: Cholesterol lowering 1.8 2.7 5.4 -2.3 -0.1
Depression (self-reported) 0.2 0.2 0.5 -0.0 0.7
Medication: Lansoprazole 1.0 1.1 2.2 -1.5 -0.4
Prospective memory result 0.2 0.3 0.5 -0.7 0.2
Lung cancer (father) 3.1 3.6 3.9 -1.8 -2.0
Illnesses of mother 0.4 0.5 0.8 0.9 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 1.8 0.1 1.3
Pulse wave Arterial Stiffness index 0.5 0.5 1.0 -0.2 1.0
Impedance of arm (left) 0.1 0.5 0.6 0.8 -0.6
Arm fat mass (right) 0.0 0.2 0.2 -0.5 0.3
Trunk predicted mass 0.2 1.3 2.5 0.1 1.6
Standing height 0.1 0.7 0.9 0.6 1.0
Length of working week for main job 0.4 0.4 0.8 -0.0 -0.9
Exposure to tobacco smoke at home 0.6 0.7 1.4 1.2 -0.0
Breastfed as a baby 0.1 0.1 0.2 -0.5 -0.2
Tense / ‘highly strung’ 0.3 0.5 0.8 -0.4 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.0 0.1 0.0 0.3
Hair/balding pattern: Pattern 4 1.3 3.2 6.3 -0.1 2.5
Birth weight of first child 0.6 1.1 1.8 -0.6 1.4
Peak expiratory flow (PEF) 0.5 1.2 1.9 -1.4 0.6
Pulse wave reflection index 0.8 1.0 1.9 -1.4 -0.2
Ever highly irritable/argumentative for 2 days 0.6 0.8 1.3 -0.5 1.1
Loud music exposure frequency 1.5 1.7 3.0 -1.7 0.6
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.2 1.1 0.5
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.2 -1.1 0.3
Blood clot in the leg (DVT) 0.1 0.1 0.1 -0.3 -0.3
Medication: Paracetamol 0.2 0.3 0.5 0.0 -0.7
Headache pain in last month 2.0 3.5 5.0 1.4 2.2
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.0 1.0 0.1
Glaucoma (self-reported) 2.4 2.8 5.1 -2.3 -0.7
Gout (self-reported) 0.1 0.2 0.2 0.4 0.4
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.5 -0.6 -0.7
Medication: Amlodipine 0.1 0.2 0.3 0.6 0.2
Medication: Ventolin 100micrograms inhaler 0.7 0.9 1.6 0.5 1.3
Birth weight 0.3 0.6 1.1 -1.0 0.3
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.5 -0.7 0.3
High blood pressure (siblings) 0.3 0.4 0.8 -0.9 0.3
Forced vital capacity (FVC), Best measure 0.0 0.1 0.3 0.0 0.5
Body fat percentage 0.1 0.5 1.0 -1.0 0.0
Leg fat percentage (right) 0.3 1.1 2.1 -1.4 -0.3
Arm fat-free mass (right) 0.2 1.3 2.3 -0.4 1.5
Exposure to tobacco smoke outside home 0.3 0.4 0.7 -0.8 -0.2
Comparative body size at age 10 0.0 0.0 0.0 -0.1 0.0
Number of full brothers 0.3 0.4 0.7 -0.2 0.8
Worry too long after embarrassment 0.5 0.8 1.5 -1.2 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.4 2.7 0.4 -1.6
Wheeze or whistling in the chest in last year 0.9 1.6 2.0 -1.4 1.1
Number of children fathered 0.4 0.4 0.6 0.8 0.5
Reason for reducing amount of alcohol drunk: Health precaution 1.8 2.1 2.2 1.4 1.5
Age at first live birth 0.2 0.3 0.5 -0.7 0.4
Pulse wave peak to peak time 0.5 0.6 1.1 0.2 -1.1
Health satisfaction 0.1 0.1 0.2 -0.5 0.3
Shortness of breath walking on level ground 1.0 1.2 2.3 -1.5 0.2
Qualifications: College or University degree 0.2 0.5 0.7 0.9 -0.6
Eye problems/disorders: None of the above 1.5 1.7 2.9 0.7 1.7
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.2 -0.1 -0.4
Emphysema/chronic bronchitis 0.8 0.9 1.1 -1.0 -0.8
Medication for pain relief, constipation, heartburn 0.9 1.6 1.7 1.3 1.2
Neck or shoulder pain in last month 0.6 0.8 1.6 -0.3 1.2
Medication: Blood pressure 0.1 0.2 0.2 -0.5 0.3
Angina (self-reported) 1.0 1.3 2.1 -1.5 -0.6
Migraine (self-reported) 0.7 0.9 1.6 1.3 -0.5
Medication: Ibuprofen 1.2 1.4 1.6 -1.3 -1.1
Medication: Allopurinol 0.0 0.0 0.0 0.2 0.2
Medication: Omeprazole 1.3 1.6 3.0 1.7 -0.3
Medication: Seretide 50 evohaler 0.8 1.0 1.7 0.4 1.3
Mean time to correctly identify matches 0.3 0.5 1.1 -1.0 0.2
Heart disease (mother) 2.1 2.6 5.1 -2.3 -0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 1.9 -1.4 1.4
Whole body fat mass 0.1 0.3 0.6 -0.8 0.1
Leg fat mass (right) 0.2 0.6 1.3 -1.1 0.1
Arm predicted mass (right) 0.2 0.8 1.5 -0.3 1.2
Pulse rate, automated reading 0.2 0.6 0.8 0.9 0.7
Alcohol intake frequency. 0.3 0.7 0.8 -0.8 -0.9
Comparative height size at age 10 0.2 1.0 1.6 -1.3 -0.5
Number of full sisters 0.5 0.6 1.2 -1.1 0.4
Suffer from ‘nerves’ 0.6 0.9 1.7 -1.3 0.3
Overall health rating 1.1 2.4 4.7 -2.2 -0.3
Chest pain or discomfort 0.3 0.4 0.7 -0.3 0.8
Had major operations 0.3 0.4 0.6 0.4 0.8
Age at last live birth 0.3 0.4 0.6 0.8 -0.4
Family relationship satisfaction 2.1 2.6 4.6 -0.8 -2.2
Leg pain on walking 2.6 3.2 6.4 -0.0 2.5
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 2.1 -1.4 0.7
Commuting to job workplace: Car/motor vehicle 0.4 0.4 0.8 0.1 0.9
Illness, injury, bereavement, stress in last 2 years 2.8 3.5 4.9 2.2 1.4
Medication: Aspirin 2.3 3.1 4.1 -2.0 -1.4
Supplements: Vitamin C 0.2 0.2 0.3 0.6 0.3
Knee pain experienced in last month 0.2 0.3 0.4 -0.5 0.6
Hypertension (Self-reported) 1.1 2.9 5.8 -2.4 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 1.0 1.4 1.2 0.8
Illnesses of father: Heart disease 0.8 1.1 2.2 0.1 -1.5
Illnesses of siblings: Diabetes 0.5 0.7 1.3 -1.2 -0.0
Smoking status: Previous 0.4 0.5 1.1 0.0 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.9 3.2 -1.8 -0.7
Whole body fat-free mass 0.1 0.8 1.7 -0.2 1.3
Leg fat-free mass (right) 0.1 0.3 0.5 -0.1 0.7
Arm fat percentage (left) 0.0 0.2 0.3 -0.6 0.2
Average weekly red wine intake 0.2 0.4 0.6 -0.7 -0.4
Handedness (chirality/laterality): Left-handed 2.8 3.4 3.9 1.7 2.0
Mood swings 1.0 1.8 2.4 -1.6 -1.1
Loneliness, isolation 0.2 0.3 0.3 -0.5 -0.6
Long-standing illness, disability or infirmity 1.2 1.9 2.1 -1.3 -1.4
Ever had bowel cancer screening 0.7 0.8 1.2 -1.1 -0.6
Diabetes diagnosed by doctor 0.7 1.1 2.1 0.4 1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.4 -0.6 0.0
Friendships satisfaction 1.9 2.4 4.0 -0.9 -2.0
Qualifications: nursing, teaching 0.0 0.1 0.1 -0.3 0.1
Commuting to job workplace: Walk 1.6 1.8 3.5 -0.1 -1.9
Eye problems/disorders: Cataract 1.8 2.1 4.1 0.1 -2.0
Mouth/teeth dental problems: Mouth ulcers 1.2 1.9 3.2 1.8 -0.8
Medication for cholesterol 0.1 0.1 0.2 0.5 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.4 -0.7 -0.4
Back pain experienced in last month 0.3 0.4 0.8 -0.9 -0.0
Mineral and other dietary supplements 0.2 0.3 0.5 -0.4 -0.7
Breast cancer (self-reported) 0.3 0.3 0.3 0.5 0.6
Asthma (self-reported) 0.7 1.4 2.2 -0.8 1.5
Osteoporosis (self-reported) 1.3 1.7 2.9 1.7 0.7
Osteoarthritis (self-reported) 0.4 0.5 0.9 -0.1 -1.0
Medication: Aspirin 1.6 2.1 3.4 -1.8 -0.9
Medication: Gliclazide 0.4 0.4 0.6 0.8 0.5
Illnesses of father: None of the above (group 1) 3.5 4.4 6.9 1.4 2.6
Smoking status: Current 0.6 1.0 1.6 0.6 1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.2 -0.4 -0.2
Whole body water mass 0.1 0.8 1.5 -0.2 1.2
Leg predicted mass (right) 0.1 0.3 0.6 -0.1 0.8
Arm fat mass (left) 0.1 0.2 0.4 -0.3 0.6
Number of self-reported non-cancer illnesses 0.3 0.5 0.9 -1.0 -0.0
Average weekly champagne plus white wine intake 0.6 0.8 0.9 0.8 1.0
Miserableness 0.3 0.5 0.8 -0.9 0.4
Guilty feelings 0.3 0.4 0.6 -0.8 -0.6
Wears glasses or contact lenses 0.1 0.1 0.1 0.3 0.4
Ever taken oral contraceptive pill 0.8 0.9 1.6 -1.3 0.4
Hearing aid user 0.2 0.2 0.4 -0.6 -0.3
Mother’s age at death 0.6 0.7 1.5 0.1 -1.2
Financial situation satisfaction 0.6 0.7 1.3 -1.1 -0.4
Tinnitus: Yes, now most or all of the time 0.4 0.4 0.4 -0.6 0.7
Commuting to job workplace: Public transport 0.1 0.1 0.2 0.5 -0.1
Eye problems/disorders: Glaucoma 1.1 1.3 2.5 -1.6 0.0
Medication: Blood pressure 0.8 1.4 1.6 -1.3 -1.1
Pain type(s) experienced in last month: Hip pain 0.3 0.3 0.6 -0.3 0.8
Supplements: Fish oil (including cod liver oil) 1.0 1.3 2.5 0.4 1.6
High cholesterol (Self-reported) 0.2 0.4 0.5 -0.6 0.7
Medication: Bendroflumethiazide 0.0 0.1 0.1 -0.2 -0.3
Medication: Paracetamol 0.2 0.3 0.5 -0.2 -0.7
Medication: Lisinopril 0.2 0.3 0.5 -0.1 -0.7
Medication: Atorvastatin 2.8 3.4 5.8 1.1 2.4
Illnesses of father: High blood pressure 2.6 3.3 4.1 -2.0 -1.6
Alcohol drinker status: Never 1.0 1.2 2.2 -0.5 -1.5
Ever smoked 0.3 0.5 0.8 0.5 -0.9
Basal metabolic rate 0.1 0.7 1.4 -0.1 1.2
Leg fat percentage (left) 0.3 0.9 1.8 -1.4 0.1
Arm fat-free mass (left) 0.2 0.9 1.7 -0.3 1.3
Number of operations (self-reported) 0.5 0.7 1.4 -1.2 -0.1
Average weekly beer plus cider intake 0.2 0.2 0.3 0.5 -0.5
Irritability 0.2 0.3 0.3 -0.5 -0.6
Risk taking 0.5 0.7 1.2 0.5 1.1
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.2 0.4 0.2
Fractured/broken bones in last 5 years 0.6 0.7 1.4 0.2 1.2
Age started oral contraceptive pill 0.6 0.8 1.0 0.8 -1.0
Diastolic blood pressure, automated reading 0.2 0.5 0.8 -0.5 0.9
Ever depressed for a whole week 0.9 1.2 2.2 0.3 1.5
Unable to work because of sickness or disability 0.3 0.3 0.5 -0.4 0.7
Commuting to job workplace: Cycle 0.2 0.3 0.5 -0.7 0.1
Myopia 0.3 0.5 0.6 0.8 0.5
Vascular/heart problems diagnosed by doctor 0.6 1.5 3.1 1.8 -0.0
Cholesterol lowering medication 0.2 0.3 0.7 0.1 0.8
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.1 1.1 -0.2
Pain experienced in last month 0.2 0.3 0.5 0.7 0.1
Supplements: Calcium 0.1 0.1 0.2 -0.3 -0.5
Basal cell carcinoma (self-reported) 1.5 1.8 3.3 1.8 -0.6
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.1 -1.0 -0.4
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.1 0.4 -0.1
Heart disease (siblings) 0.7 0.9 1.4 -1.2 -0.6
Alcohol drinker status: Previous 0.9 1.0 1.9 -1.4 -0.4
Pack years of smoking 0.4 0.7 0.7 0.8 0.8
Impedance of whole body 0.0 0.2 0.2 0.5 -0.4
Leg fat mass (left) 0.1 0.5 1.0 -1.0 0.3
Arm predicted mass (left) 0.2 0.8 1.5 -0.4 1.2