Best TWAS P=4.65e-09 · Best GWAS P=2.27e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | MDM4 | 0.11 | 0.09 | lasso | 1 | 0.07 | 1.6e-05 | -5.1 | -5.1 | 3.0e-07 | -0.59 | 0.06 | 0.94 | FALSE |
| 2 | YFS | Blood | PIK3C2B | 0.03 | 0.02 | lasso | 5 | 0.02 | 7.0e-08 | 5.6 | -5.9 | 4.7e-09 | -0.98 | 0.01 | 0.99 | TRUE |
| 3 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MDM4 | 0.02 | 0.03 | enet | 4 | 0.03 | 5.5e-04 | -5.2 | -5.3 | 9.5e-08 | -0.52 | 0.05 | 0.92 | FALSE |
| 4 | The Cancer Genome Atlas | Thyroid Carcinoma | MDM4 | 0.05 | 0.06 | lasso | 1 | 0.04 | 1.6e-04 | -5.1 | -5.1 | 3.0e-07 | -0.59 | 0.06 | 0.93 | FALSE |