Hub : Genes

PIK3C2B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.1800	0.0550	2.5e-04	0.157	NA	0.135	NA	0.154	1.1e-10	NA	2.6e-09	NA	1.8e-10
2	GTEx	Skin Sun Exposed Lower leg	0.2050	0.0540	1.2e-06	0.076	NA	0.117	NA	0.111	7.5e-07	NA	6.4e-10	NA	1.8e-09
3	GTEx	Testis	0.1660	0.0610	2.0e-03	0.095	NA	0.015	NA	0.032	5.4e-05	NA	6.6e-02	NA	1.5e-02
4	METSIM	Adipose	0.1057	0.0345	3.5e-05	0.001	0.023	0.023	NA	0.013	2.0e-01	1.7e-04	1.9e-04	NA	4.2e-03
5	YFS	Blood	0.0321	0.0101	3.8e-06	0.024	0.021	0.018	0.021	0.022	2.3e-08	1.4e-07	7.7e-07	1.5e-07	7.0e-08
6	TCGA	Esophageal Carcinoma	0.1660	0.0880	4.8e-03	0.019	0.062	0.045	NA	0.041	8.2e-02	5.1e-03	1.5e-02	NA	1.9e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.6	1.0	3.8	0.3	-0.2	-1.1	0.0	-2.0	-0.9
Bipolar Disorder or Schizophrenia	1.7	4.0	8.8	2.2	-2.2	-3.0	-1.5	-1.9	0.0
Depressed Affect (Nagel 2018)	2.2	4.6	11.6	-3.4	1.9	0.9	0.7	-1.6	-2.9
Depression (Nagel 2018)	0.8	1.1	3.2	-0.9	0.2	-0.8	-0.8	-1.8	-1.2
Intelligence (Savage-Jansen 2018)	1.7	5.2	7.5	2.7	-2.4	-2.2	-2.3	0.9	2.7
Neuroticism (Nagel 2018)	1.7	4.0	9.5	-3.1	2.0	1.1	0.8	-1.3	-2.6
Schizophrenia (2018)	2.3	4.7	8.3	2.6	-2.8	-2.9	-2.0	-0.9	0.7
Schizophrenia vs Biploar Disorder	0.1	0.2	0.7	0.2	-0.4	-0.8	-0.2	0.4	-0.1
Worry (Nagel 2018)	1.2	2.6	4.3	-1.9	2.1	2.1	1.1	0.1	-1.3
Alzheimer’s Disease (in mother)	1.0	1.1	2.8	-1.6	1.7	0.7	0.2	0.2	-0.7
Alzheimer’s Disease (in father)	0.3	0.3	0.7	-0.8	0.3	-0.2	-0.3	-0.6	-0.9
Alzheimer’s Disease (including proxy)	0.8	1.2	2.5	-1.6	1.6	1.2	0.2	0.8	-0.3
Crohns Disease (2017)	0.4	0.8	2.6	0.5	-0.4	1.6	-1.3	0.4	0.5
Irritable Bowel Disease (IBD)	0.9	2.0	3.0	1.6	-1.7	0.8	-1.7	0.5	1.7
Ulcerative Colitis (UC)	1.1	2.1	4.6	1.5	-1.8	0.1	-1.4	0.7	2.1
Major Depression (MDD)	0.7	0.8	1.9	0.6	-0.9	-1.4	-0.5	-1.3	-0.3
Reaction Time	0.2	0.4	0.5	0.6	-0.6	-0.7	-0.7	0.5	0.5
Verbal and Numeric Reasoning (VNR)	1.3	3.2	5.7	1.7	-2.0	-2.4	-1.6	0.4	2.0
Breast Cancer	1.6	3.8	11.0	1.7	-2.2	-3.3	-1.5	-1.4	0.0
Ovarian Cancer	1.8	2.4	4.8	1.1	-1.9	-2.2	-1.9	-1.1	0.4
Prostate Cancer	11.3	15.9	45.5	3.2	-4.8	-6.7	-3.6	-2.0	0.3
Age at First Birth	0.5	0.7	2.1	0.7	-0.3	0.4	-0.8	0.7	1.5
Bipolar Disorder (2011)	1.1	1.1	3.1	1.3	-1.8	-1.1	-0.7	-0.5	0.0
Body Mass Index (BMI) (2010)	0.8	1.1	2.1	1.1	-1.4	-0.3	-1.3	0.6	1.0
Coronary Artery Disease (CAD)	1.2	1.5	3.6	1.4	-1.9	-0.7	-1.1	0.5	1.2
Crohns Disease (2012)	0.9	1.5	4.8	0.1	1.0	2.2	-0.5	1.2	1.2
Mean Putamen Volume	0.8	0.9	2.3	1.0	-1.5	-1.0	-0.5	-0.2	0.7
Fasting Glucose	0.6	0.7	1.9	-0.1	0.9	1.4	0.5	0.4	1.1
HbA1C	0.8	0.9	1.4	-0.8	1.1	1.0	1.2	0.8	-0.7
HDL Cholesterol	0.0	0.0	0.1	0.1	-0.3	-0.3	0.2	-0.0	0.2
LDL Cholesterol	2.3	3.6	6.9	-1.5	2.3	2.5	2.6	1.1	0.0
Lupus	0.4	0.6	2.2	0.4	0.0	0.4	1.0	0.5	1.5
Neuroticism (2016)	0.8	1.2	5.0	-2.2	0.7	0.1	0.6	-0.8	-0.7
Primary Biliary Cirrhosis	0.3	0.4	1.1	-0.6	0.5	-0.6	1.1	0.3	0.3
Rheumatoid Arthritis	2.1	2.8	6.2	-2.5	2.0	1.5	1.4	-0.2	-1.5
Schizophrenia (2014)	2.5	5.6	9.5	2.8	-3.0	-3.1	-2.4	-1.1	0.3
Triglycerides	0.5	0.8	1.4	-1.2	1.0	0.9	0.3	-0.7	-0.9
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.4	0.1	-0.4	-0.6	-1.2	-0.7	-0.1
Ulcerative Colitis	0.9	1.3	3.6	0.8	-0.9	0.2	-1.5	0.6	1.9
Blood Eosinophil Count	1.9	14.3	34.3	-3.0	-0.3	-4.6	-1.6	-5.9	-4.3
Blood Platelet Count	1.4	15.7	40.3	-4.6	0.4	-1.8	-1.2	-6.3	-5.2
Blood Red Count	0.2	1.8	4.2	-0.2	-0.3	-2.0	-1.1	-2.0	-1.2
Blood White Count	0.3	2.3	5.5	-2.0	2.4	1.9	0.1	-0.5	-0.7
Heel T-Score	0.2	1.3	2.9	1.1	-1.6	-0.7	-1.7	0.4	0.7
BMI	0.3	1.6	4.4	-1.6	1.1	0.6	0.8	-0.6	-2.1
Height	0.4	7.4	25.4	1.4	-1.7	-5.0	-1.7	-3.1	-1.2
Waist Hip Ratio (WHR)	3.0	13.6	26.5	-5.1	4.1	0.1	1.2	-3.3	-5.2
Systolic Blood Pressure	0.2	1.2	2.6	0.7	-1.6	-1.6	-1.2	0.3	-0.4
Smoking Status	1.0	2.5	7.5	-1.1	1.1	-1.1	1.1	-2.7	-1.6
Allergy or Eczema	0.5	1.4	4.2	1.0	-1.3	-2.0	-0.7	-0.3	1.0
Cardiovascular Disease	1.3	4.2	11.8	0.5	-2.5	-3.4	-2.2	-1.5	-0.1
Hypothyroidism (self reported)	0.2	0.5	1.5	-0.2	0.6	-0.4	0.2	-1.0	-1.2
Respiratory disease	2.0	4.4	9.7	-0.4	-0.8	-2.8	-1.8	-3.1	-2.2
Type 2 Diabetes (T2D) (2018)	2.7	5.1	10.2	-3.2	3.0	2.2	0.6	-1.2	-2.1
Lung FEV1/FVC ratio	1.3	6.4	12.2	2.8	-1.7	2.3	-0.8	3.5	3.0
Lung FVC	6.1	31.2	51.9	7.1	-7.2	-6.8	-4.7	-0.6	4.1
Neuroticism	2.1	5.1	13.2	-3.6	2.4	1.4	1.6	-1.0	-2.4
Chronotype (morning person)	0.8	2.0	3.9	-0.8	1.6	2.0	1.9	0.9	-0.2
Hair Pigment	0.1	3.9	7.3	2.2	-1.3	-2.6	1.4	-2.7	-1.3
Tanning	0.1	1.4	3.1	-0.2	-0.9	-0.9	-0.9	-1.8	-1.7
Hand grip strength (left)	2.3	6.2	12.0	2.6	-3.5	-3.4	-2.3	-0.6	1.0
Number of treatments/medications taken	0.3	0.6	2.1	0.7	-0.5	-1.5	-0.7	-0.4	0.4
Average weekly spirits intake	1.1	1.3	2.6	-1.4	1.2	1.2	1.6	0.4	-0.6
Sensitivity / hurt feelings	1.5	2.5	6.8	-1.5	1.0	-0.4	1.1	-1.8	-2.6
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.5	-1.2	-0.1	0.1	0.1	-0.7	-0.8
Hearing difficulty/problems: Yes	1.5	2.2	8.2	-1.1	-0.0	-1.0	0.3	-2.9	-1.7
Relative age of first facial hair	3.2	6.6	19.9	1.1	-2.4	-4.5	-2.1	-2.5	-1.6
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.9	1.3	-1.7	-1.5	-0.6	-0.2	0.8
Ever used hormone-replacement therapy (HRT)	1.2	1.6	5.6	-0.3	-0.2	-1.5	-0.2	-2.4	-1.2
Ever had hysterectomy (womb removed)	0.5	0.5	1.0	1.0	-0.4	-0.7	-1.0	0.5	0.5
Systolic blood pressure, automated reading	0.0	0.1	0.3	0.1	-0.5	0.3	0.1	0.5	0.1
Eye problems/disorders: Diabetes related eye disease	3.5	3.9	9.7	-1.7	0.8	3.1	2.5	1.9	0.3
Angina	0.4	0.5	1.6	-0.2	0.3	-0.4	0.1	-0.9	-1.2
Medication for hormone replacement therapy	1.0	1.1	2.5	-1.1	1.1	0.8	1.1	-0.6	-1.6
Vitamin and mineral supplements	3.5	4.7	10.2	-3.2	2.5	0.2	0.2	-2.1	-2.7
Supplements: Zinc	2.7	3.0	9.3	3.0	-1.9	-0.2	-0.4	0.8	2.0
Medication: Co-codamol	0.1	0.1	0.5	0.3	-0.7	-0.3	-0.3	-0.3	-0.1
Medication: Metformin	2.3	3.3	5.8	-1.9	2.4	2.4	1.3	-0.5	-1.4
Diabetes (father)	0.5	0.6	1.3	-0.7	0.8	1.2	0.8	0.7	0.2
Diabetes (mother)	0.4	0.5	1.5	-1.2	0.9	0.9	0.2	0.3	-0.3
Severe depression (siblings)	0.6	0.7	1.6	0.3	-0.1	0.9	0.7	1.2	1.1
Pack years adult smoking proportion	3.9	6.0	9.8	-3.0	3.1	0.8	1.9	-1.9	-3.0
Impedance of leg (right)	0.4	2.0	5.0	-1.3	2.2	2.0	0.8	0.2	-0.4
Leg fat-free mass (left)	0.4	2.0	4.4	-1.0	0.2	-1.9	0.2	-1.6	-2.1
Trunk fat percentage	1.6	6.6	12.2	-3.5	3.3	2.8	1.7	0.2	-2.4
Hand grip strength (right)	1.9	5.2	10.2	2.7	-3.2	-3.1	-1.8	-0.8	0.6
Townsend deprivation index at recruitment	1.8	2.5	5.7	-1.6	1.1	-1.7	1.1	-1.4	-2.4
Current tobacco smoking	1.7	2.8	5.7	-2.4	1.2	-0.3	1.4	-1.6	-2.2
Average weekly fortified wine intake	0.1	0.1	0.6	0.4	-0.1	0.2	-0.1	-0.8	0.0
Maternal smoking around birth	3.2	4.6	11.3	-2.5	1.9	0.1	0.6	-2.4	-3.4
Fed-up feelings	3.0	5.4	14.4	-3.8	1.6	0.1	1.6	-2.0	-3.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	5.0	-2.2	0.8	-0.5	1.0	-1.7	-1.3
Relative age voice broke	1.3	2.0	7.5	1.1	-1.0	-2.7	-0.4	-1.4	-0.5
Taking other prescription medications	0.6	0.9	2.3	0.1	-1.0	-1.5	-0.5	-1.2	-0.5
Age when periods started (menarche)	0.4	1.0	3.8	0.4	-0.8	-2.0	-0.2	-1.0	-0.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.0	1.0	-0.4	-0.3	-0.8	-0.3	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	2.5	0.8	-0.5	-0.0	0.1	1.6	1.1
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	0.4	-0.3	0.5	-0.2	-0.0	0.4
Qualifications: CSEs or equivalent	0.9	1.2	2.3	-1.0	1.1	1.3	0.7	1.5	-0.5
Serious illness, injury or assault to yourself	0.2	0.2	0.8	-0.6	0.1	-0.9	-0.1	0.1	0.2
High blood pressure	2.2	6.2	15.6	1.6	-3.5	-4.0	-2.4	-0.8	0.6
Hayfever, allergic rhinitis or eczema	0.9	1.9	5.0	1.4	-1.4	-2.2	-0.5	-0.2	1.4
Multivitamins +/- minerals	1.5	1.9	4.3	2.1	-1.6	0.2	0.1	1.3	1.7
Stomach or abdominal pain in last month	0.2	0.3	0.6	-0.8	0.0	-0.4	0.7	0.1	-0.5
Supplements: Glucosamine	2.0	2.6	6.3	2.5	-1.2	0.4	0.3	1.6	2.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.8	0.0	-1.3	0.2	-0.3	-0.1	0.8
Medication: Atenolol	1.3	1.7	3.8	-0.0	0.1	-1.7	-1.1	-2.0	-1.4
Medication: Levothyroxine sodium	0.3	0.5	1.3	0.2	1.1	0.3	1.0	-0.3	0.7
Sitting height	1.0	7.0	13.0	-2.6	1.6	-2.6	1.8	-3.2	-3.6
Chronic bronchitis/emphysema (father)	0.2	0.3	0.5	-0.3	0.4	-0.6	0.5	-0.5	-0.7
High blood pressure (mother)	3.9	5.5	17.1	0.4	-2.7	-4.1	-1.5	-2.3	-1.0
Body mass index (BMI)	0.6	2.4	4.9	-2.2	1.6	1.2	1.2	-0.2	-2.0
Impedance of leg (left)	0.5	2.3	6.1	-1.0	2.3	2.5	0.8	0.9	0.1
Leg predicted mass (left)	0.4	1.9	4.3	-1.0	0.2	-1.9	0.1	-1.6	-2.1
Trunk fat mass	1.3	5.4	10.4	-3.2	2.9	1.8	1.6	-0.4	-2.7
Waist circumference	1.8	6.7	14.8	-3.9	2.8	0.8	1.6	-1.8	-3.4
Number of incorrect matches in round	0.8	1.3	3.7	1.4	-0.6	1.1	0.5	0.4	1.9
Past tobacco smoking	1.1	1.9	7.3	0.3	-0.3	1.4	-0.3	2.7	1.5
Alcohol usually taken with meals	4.6	7.5	13.0	3.6	-2.6	0.3	-2.2	2.8	3.5
Nervous feelings	1.0	1.8	3.9	-2.0	1.2	0.4	1.4	-1.3	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.4	0.1	-0.5	-0.4	0.6	-1.2	0.4
Hearing difficulty/problems with background noise	0.4	0.6	1.5	0.6	-0.1	-0.5	1.1	-0.4	1.2
Hair/balding pattern: Pattern 2	1.6	2.1	6.7	-2.6	1.2	-0.1	0.6	-0.8	-1.8
Had menopause	2.5	3.1	7.0	2.5	-1.2	1.2	-0.8	1.4	2.6
Had other major operations	0.4	0.5	1.0	0.8	-0.8	-1.0	0.2	-0.6	0.4
Forced vital capacity (FVC)	3.3	12.6	31.9	3.5	-3.9	-5.7	-3.3	-2.0	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.1	0.4	-0.4	0.4	0.7	1.1	0.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.7	-0.9	0.6	0.1	1.3	-0.7	-0.3
Qualifications: None of the above	2.4	5.1	11.8	-3.4	2.1	1.5	2.0	-1.5	-2.5
Financial difficulties in last 2 years	1.9	2.5	6.9	-2.4	0.7	0.2	0.3	-1.4	-2.6
Mouth/teeth dental problems	0.6	1.0	2.8	1.3	-1.7	-0.6	-0.8	-0.4	0.3
Heart attack	0.3	0.4	1.0	-0.1	-0.7	-0.9	0.0	-0.5	-1.0
Allergy	0.6	1.5	5.1	-0.2	1.2	2.3	0.1	1.4	0.4
Pain all over the body in last month	0.1	0.1	0.4	0.4	-0.6	-0.0	0.2	0.2	0.5
Diabetes (self-reported)	3.1	4.8	8.5	-2.7	2.9	2.7	1.5	-0.8	-1.7
Hayfever/allergic rhinitis (self-reported)	2.1	2.8	10.7	0.7	-2.2	-3.3	-0.6	-0.4	0.3
Medication: Ramipril	2.4	3.1	8.3	0.9	-2.2	-2.0	-2.9	-0.2	0.6
Medication: Simvastatin	0.4	0.6	2.0	0.2	-1.0	-0.3	-1.4	-0.2	0.8
Fluid intelligence score	1.5	3.1	7.7	1.8	-2.0	-2.8	-1.6	-0.4	1.1
Illnesses of siblings	0.7	1.0	4.8	0.4	0.5	2.2	-0.2	0.7	0.4
Neuroticism score	2.2	4.5	11.8	-3.4	1.9	0.9	1.9	-1.6	-2.3
Weight	0.6	3.1	7.3	-2.3	1.8	0.0	1.0	-1.1	-2.7
Impedance of arm (right)	0.4	2.1	5.0	-1.5	1.7	2.2	-0.3	1.5	0.4
Arm fat percentage (right)	1.1	4.3	9.5	-3.1	2.4	2.2	1.4	0.4	-1.9
Trunk fat-free mass	0.5	3.1	9.4	0.1	-0.5	-3.1	0.0	-2.5	-1.7
Hip circumference	0.3	1.3	3.6	-1.9	1.3	0.3	0.7	-0.5	-1.3
Time employed in main current job	1.8	2.0	4.3	1.5	-1.4	-1.7	-2.1	-0.5	0.5
Alcohol intake versus 10 years previously	1.4	2.1	4.4	-2.1	1.3	0.2	1.6	-1.0	-1.8
Father’s age at death	0.7	1.0	3.1	-0.4	0.8	-0.6	1.1	-1.8	-0.6
Worrier / anxious feelings	0.9	1.7	2.8	-1.6	1.5	1.7	1.3	0.6	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	6.2	-2.5	0.4	-0.9	1.3	-2.0	-1.9
Falls in the last year	1.8	2.4	4.2	1.6	-1.1	0.3	-2.0	1.6	2.1
Hair/balding pattern: Pattern 3	1.6	2.5	4.6	2.1	-0.8	1.2	-0.5	2.1	1.8
Number of live births	1.2	1.8	3.3	1.2	-1.0	1.4	0.4	1.6	1.8
Forced expiratory volume in 1-second (FEV1)	3.4	11.4	24.2	3.8	-4.1	-4.9	-3.3	-1.2	0.9
Pulse rate	2.2	3.7	8.4	-2.9	2.1	-0.3	0.5	-1.9	-2.3
Happiness	1.1	1.4	4.6	-2.1	0.9	-0.0	0.9	-0.9	-1.0
Noisy workplace	0.7	0.8	2.7	0.3	0.6	1.3	1.6	0.1	0.2
Qualifications: A levels/AS levels or equivalent	1.3	2.9	7.0	1.2	-1.7	-1.2	-2.6	1.2	1.8
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.8	3.8	1.5	-0.9	-1.5	-1.2	0.1	2.0
Mouth/teeth dental problems: Dentures	1.2	1.9	4.4	-1.8	2.1	1.7	1.0	0.4	-0.2
Asthma	0.7	1.4	3.5	-0.4	-0.7	-1.5	-0.4	-1.9	-1.4
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.5	0.1	0.8	1.2	1.1	0.4	0.1
Medication: Cholesterol lowering	0.2	0.3	1.2	0.0	-0.5	-0.0	-0.5	1.1	0.1
Depression (self-reported)	1.6	1.9	5.2	-2.3	1.4	0.0	2.0	-0.3	-0.4
Medication: Lansoprazole	1.0	1.2	3.9	0.3	-0.9	-2.0	-0.9	-1.1	-0.2
Prospective memory result	1.2	1.5	5.7	-1.1	0.1	-0.7	-0.2	-1.3	-2.4
Lung cancer (father)	3.3	3.9	11.7	-1.2	2.2	3.4	1.6	1.6	-0.6
Illnesses of mother	1.2	1.5	3.1	1.8	0.1	1.7	-0.3	0.9	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	3.6	11.6	21.7	4.0	-4.5	-4.7	-2.9	-0.6	1.6
Pulse wave Arterial Stiffness index	0.9	1.0	1.6	-1.1	1.1	1.2	0.8	-0.2	-1.2
Impedance of arm (left)	0.4	1.9	4.0	-1.7	1.6	2.0	0.1	1.4	-0.0
Arm fat mass (right)	1.0	4.1	8.8	-3.0	2.3	1.2	1.6	-0.6	-2.5
Trunk predicted mass	0.5	3.1	9.2	-0.0	-0.5	-3.0	0.1	-2.5	-1.7
Standing height	0.3	2.9	8.2	-0.3	0.4	-2.9	-0.6	-2.4	-1.8
Length of working week for main job	2.8	3.1	7.3	2.1	-0.8	-0.4	-1.3	2.1	2.7
Exposure to tobacco smoke at home	0.2	0.3	0.7	0.5	-0.7	-0.2	-0.1	0.5	0.8
Breastfed as a baby	1.2	1.5	2.8	1.6	-1.4	-1.1	-0.9	-0.0	1.7
Tense / ‘highly strung’	0.5	0.8	1.6	-1.3	1.1	0.9	0.8	-0.5	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.7	6.2	-2.5	0.5	-1.1	1.1	-2.2	-1.7
Hair/balding pattern: Pattern 4	0.3	0.6	1.2	0.4	-0.7	1.1	-0.8	0.5	1.1
Birth weight of first child	0.1	0.3	0.7	0.3	-0.5	-0.1	0.6	0.5	0.8
Peak expiratory flow (PEF)	5.0	11.5	20.8	3.2	-4.0	-4.4	-4.6	-1.6	0.3
Pulse wave reflection index	0.2	0.3	0.8	0.4	-0.3	0.1	-0.9	0.7	0.4
Ever highly irritable/argumentative for 2 days	1.6	2.0	5.2	-1.5	0.6	1.9	2.3	0.5	-0.3
Loud music exposure frequency	2.7	3.0	6.2	-2.1	2.5	2.0	1.1	0.5	-1.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	2.0	1.1	-0.7	-0.2	-1.4	0.3	0.7
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	4.7	-1.7	2.2	0.8	1.9	0.3	-1.5
Blood clot in the leg (DVT)	0.1	0.1	0.5	-0.2	-0.3	0.4	0.2	-0.7	-0.1
Medication: Paracetamol	0.6	1.0	2.3	-0.9	1.3	0.9	1.5	0.6	0.0
Headache pain in last month	0.2	0.3	1.3	0.2	0.1	0.3	-0.4	1.1	0.2
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	3.5	-1.0	1.4	1.9	1.7	-0.2	-0.5
Glaucoma (self-reported)	2.7	3.2	6.9	1.7	-1.1	1.1	-0.4	2.6	2.6
Gout (self-reported)	0.6	0.8	1.8	0.4	-0.1	0.9	1.0	1.3	1.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	-0.1	0.4	-0.6	0.2	-0.7	-0.4
Medication: Amlodipine	0.9	1.2	4.2	-0.0	-1.6	-2.1	0.2	-0.7	-0.2
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.6	-0.4	0.2	0.2	-0.8	-0.4	-0.7
Birth weight	2.4	5.2	8.9	3.0	-2.7	-1.1	-1.1	1.9	3.0
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.1	-1.3	1.5	-0.0	1.1	-1.0	-1.2
High blood pressure (siblings)	1.4	2.1	7.3	1.0	-1.7	-2.7	0.4	-0.9	-0.1
Forced vital capacity (FVC), Best measure	3.5	12.9	30.9	3.7	-4.5	-5.6	-3.0	-1.7	1.2
Body fat percentage	1.6	6.5	11.6	-3.4	3.2	2.9	1.9	0.3	-2.2
Leg fat percentage (right)	1.4	4.9	7.8	-2.8	2.5	2.8	2.0	0.3	-1.8
Arm fat-free mass (right)	0.5	2.6	5.4	-0.8	0.6	-1.9	1.0	-2.3	-2.2
Exposure to tobacco smoke outside home	0.5	0.7	1.8	-0.3	0.6	1.3	1.1	0.9	-0.0
Comparative body size at age 10	1.2	3.3	6.1	1.7	-2.2	-2.3	-2.5	-0.3	0.5
Number of full brothers	0.8	1.0	4.3	0.8	-0.7	-2.1	-0.4	-0.7	-0.4
Worry too long after embarrassment	0.4	0.7	2.2	-1.5	1.0	0.8	0.7	-0.1	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.0	0.2	-0.2	0.3	1.0	-0.2	0.7
Wheeze or whistling in the chest in last year	1.5	2.7	6.5	-1.6	0.0	-1.3	0.2	-2.5	-2.3
Number of children fathered	1.8	2.0	4.1	2.0	-1.9	-0.2	-1.1	1.3	1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.0	4.6	2.1	-0.7	-1.6	-2.0	-0.0	0.6
Age at first live birth	0.3	0.5	1.1	0.7	-1.1	-0.8	-0.7	0.0	0.3
Pulse wave peak to peak time	0.8	1.0	2.4	0.9	-1.0	-1.6	-0.9	-0.3	0.8
Health satisfaction	0.4	0.6	1.4	-1.2	0.8	-0.3	-0.1	-0.7	-0.9
Shortness of breath walking on level ground	1.8	2.1	8.6	-1.1	0.4	-1.0	0.8	-2.9	-1.1
Qualifications: College or University degree	4.5	14.2	28.7	5.4	-4.0	-2.6	-3.1	2.2	4.3
Eye problems/disorders: None of the above	1.0	1.2	2.7	-1.1	1.6	-0.5	0.1	-1.0	-1.5
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.3	1.4	-0.6	-1.5	-0.1	0.0	0.4
Emphysema/chronic bronchitis	0.5	0.5	1.3	0.0	-1.1	-0.9	-0.4	-0.9	-0.5
Medication for pain relief, constipation, heartburn	0.3	0.5	1.6	0.8	-1.2	-0.6	-0.5	0.1	0.3
Neck or shoulder pain in last month	1.4	2.0	3.9	2.0	-1.5	-0.7	0.2	1.1	2.0
Medication: Blood pressure	1.6	2.9	6.0	1.8	-1.8	-2.5	-2.0	-0.0	0.9
Angina (self-reported)	0.3	0.4	1.5	-0.2	0.1	-0.5	-0.0	-0.8	-1.2
Migraine (self-reported)	2.1	2.6	3.8	2.0	-1.6	-1.5	-1.7	1.4	1.5
Medication: Ibuprofen	0.3	0.4	0.9	0.6	0.4	1.0	0.5	0.4	0.6
Medication: Allopurinol	0.7	0.9	2.9	-0.5	0.5	1.0	1.7	0.9	0.4
Medication: Omeprazole	1.8	2.2	4.2	2.0	-1.8	-1.2	-0.7	0.8	1.8
Medication: Seretide 50 evohaler	2.1	2.5	4.5	-1.3	0.0	-1.5	-1.4	-2.1	-2.1
Mean time to correctly identify matches	0.7	1.3	2.6	1.5	-1.1	-0.8	-1.1	0.1	1.6
Heart disease (mother)	1.0	1.2	2.9	0.9	-1.7	-1.3	-1.2	0.2	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.9	-1.0	0.7	0.7	-0.2	-0.1	-0.1
Whole body fat mass	1.3	5.3	10.1	-3.2	2.8	1.6	1.7	-0.5	-2.8
Leg fat mass (right)	1.1	4.4	8.2	-2.9	2.5	1.5	1.7	-0.6	-2.5
Arm predicted mass (right)	0.5	2.8	5.6	-0.8	0.6	-2.1	0.6	-2.4	-2.3
Pulse rate, automated reading	0.3	1.0	4.1	-2.0	0.7	0.8	0.0	-0.1	-0.8
Alcohol intake frequency.	0.1	0.3	1.5	-1.2	-0.1	0.1	0.5	0.2	-0.2
Comparative height size at age 10	0.1	0.3	1.0	0.5	0.4	-0.4	-1.0	-0.7	-0.3
Number of full sisters	0.4	0.5	1.1	0.3	0.1	0.6	0.6	1.1	1.0
Suffer from ‘nerves’	0.3	0.5	1.5	-0.5	1.2	0.6	0.1	-0.5	-0.7
Overall health rating	2.4	5.1	10.2	-3.0	2.0	-0.1	2.0	-1.9	-3.2
Chest pain or discomfort	1.6	2.3	5.4	-0.3	-0.5	-1.7	-2.1	-2.3	-0.9
Had major operations	0.8	0.9	3.6	0.5	-0.5	0.1	1.9	1.2	-0.0
Age at last live birth	0.6	0.9	1.5	1.0	-0.7	1.1	-0.1	1.2	1.2
Family relationship satisfaction	1.2	1.5	5.8	-0.9	1.1	0.8	2.4	-0.5	-0.5
Leg pain on walking	1.1	1.4	3.6	0.9	-1.0	0.6	-0.6	1.9	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	3.0	-0.7	0.8	1.7	1.3	0.1	-1.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	0.3	-0.6	-0.1	0.6	-0.5	0.1
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	3.0	1.7	-1.0	0.2	-0.0	1.4	1.4
Medication: Aspirin	1.3	1.8	4.4	1.1	-1.5	-2.1	-1.2	-1.1	-0.1
Supplements: Vitamin C	2.3	2.7	5.3	1.9	-1.8	-0.6	-0.8	1.8	2.3
Knee pain experienced in last month	1.5	2.3	5.9	0.5	-1.3	-2.4	-1.0	-2.1	-0.9
Hypertension (Self-reported)	1.9	5.2	14.5	1.1	-3.0	-3.8	-2.2	-1.1	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.3	0.5	-0.5	-0.6	0.1	0.6	0.4
Illnesses of father: Heart disease	1.7	2.4	6.7	0.4	-2.3	-2.6	-1.1	-1.1	-0.4
Illnesses of siblings: Diabetes	0.2	0.3	1.1	-0.7	-0.3	-0.1	1.1	-0.0	0.2
Smoking status: Previous	0.8	1.2	3.0	1.1	-0.5	-1.5	-0.6	-1.7	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.7	-0.4	0.2	-1.6	-0.5	-0.7	-0.8
Whole body fat-free mass	0.4	2.5	6.7	-0.3	-0.2	-2.6	0.0	-2.2	-1.8
Leg fat-free mass (right)	0.3	1.4	3.7	-0.5	-0.1	-1.9	-0.2	-1.4	-1.6
Arm fat percentage (left)	1.2	4.6	9.9	-3.1	2.4	2.2	1.6	0.4	-2.1
Average weekly red wine intake	3.2	4.8	11.0	3.1	-1.6	-0.2	-1.3	2.0	3.3
Handedness (chirality/laterality): Left-handed	0.9	1.0	2.9	0.6	0.1	1.7	-0.3	1.2	1.2
Mood swings	1.7	3.1	9.4	-3.1	1.6	0.8	1.0	-1.0	-2.1
Loneliness, isolation	0.4	0.6	1.4	-1.1	-0.0	0.5	-0.3	-0.7	-1.2
Long-standing illness, disability or infirmity	0.3	0.4	1.3	-0.1	-1.1	-0.7	-0.4	-0.6	-0.4
Ever had bowel cancer screening	2.8	3.3	7.1	2.4	-2.7	-1.5	-0.8	0.6	2.0
Diabetes diagnosed by doctor	2.6	4.3	7.5	-2.6	2.7	2.5	1.6	-0.5	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.4	0.0	0.5	0.8	-1.2	-0.3	-0.3
Friendships satisfaction	0.1	0.1	0.2	0.4	-0.4	-0.1	0.5	-0.1	0.1
Qualifications: nursing, teaching	3.4	5.3	9.3	2.7	-2.5	-0.1	-2.3	1.9	3.1
Commuting to job workplace: Walk	1.3	1.4	3.7	1.1	-0.5	-0.2	-1.9	1.3	1.3
Eye problems/disorders: Cataract	0.3	0.3	1.0	-0.3	-0.2	0.3	-0.4	0.8	1.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.2	-0.3	-0.1	-0.4	-1.1	0.7	0.4
Medication for cholesterol	0.9	1.4	3.9	0.9	-0.1	1.1	0.6	2.0	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.2	0.0	0.3	-1.2	-0.8	-1.5	-0.3
Back pain experienced in last month	0.4	0.6	1.3	0.4	-0.6	0.6	0.7	1.0	1.1
Mineral and other dietary supplements	6.6	8.8	19.7	-4.4	3.0	0.1	1.2	-2.7	-3.9
Breast cancer (self-reported)	0.5	0.6	1.7	1.1	0.2	0.8	0.0	0.1	1.3
Asthma (self-reported)	0.7	1.4	3.7	-1.0	-0.3	-1.0	-0.4	-1.9	-1.6
Osteoporosis (self-reported)	0.6	0.8	1.8	0.0	0.2	1.4	0.3	1.4	0.8
Osteoarthritis (self-reported)	0.5	0.7	1.9	-0.1	0.2	-0.0	1.4	-0.9	-1.1
Medication: Aspirin	0.8	1.1	2.6	0.4	-0.9	-1.6	-0.5	-1.3	-0.9
Medication: Gliclazide	0.5	0.6	2.0	-0.3	0.3	1.4	1.1	0.4	0.2
Illnesses of father: None of the above (group 1)	2.0	2.5	11.3	-0.4	1.5	3.4	0.7	0.9	0.4
Smoking status: Current	1.8	2.8	5.8	-2.4	1.3	-0.1	1.6	-1.5	-2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.0	8.4	15.4	3.5	-3.9	-3.4	-2.4	-0.2	2.4
Whole body water mass	0.4	2.4	7.0	-0.3	-0.2	-2.6	0.1	-2.1	-1.8
Leg predicted mass (right)	0.3	1.5	4.1	-0.4	-0.1	-2.0	-0.2	-1.4	-1.6
Arm fat mass (left)	1.0	4.2	8.9	-3.0	2.3	1.3	1.6	-0.4	-2.5
Number of self-reported non-cancer illnesses	0.7	1.2	3.8	-0.2	-0.8	-1.9	-1.6	-0.0	-0.5
Average weekly champagne plus white wine intake	2.4	3.4	6.7	2.2	-2.6	-0.3	-1.4	1.6	1.9
Miserableness	3.3	5.7	12.1	-3.5	1.5	-0.8	0.5	-2.9	-3.3
Guilty feelings	1.3	1.9	4.8	-2.2	1.3	0.4	1.5	-1.0	-1.3
Wears glasses or contact lenses	6.0	7.0	14.2	3.8	-2.7	0.3	-2.5	1.6	3.3
Ever taken oral contraceptive pill	0.9	1.0	2.9	-0.6	-0.5	-1.7	-0.2	-1.5	-0.3
Hearing aid user	1.1	1.2	4.2	0.3	-0.9	-1.3	-0.7	-2.0	0.1
Mother’s age at death	0.6	0.7	2.7	0.5	-0.4	-0.5	1.6	-0.9	0.4
Financial situation satisfaction	0.7	0.9	2.3	-0.8	1.5	0.2	0.8	-0.8	-1.0
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.0	0.9	0.2	-0.2	-1.0	-0.0	0.4
Commuting to job workplace: Public transport	0.7	0.8	2.9	0.7	0.2	0.9	0.1	1.7	0.6
Eye problems/disorders: Glaucoma	0.8	0.9	2.6	1.0	-0.6	0.4	-0.7	1.0	1.6
Medication: Blood pressure	2.1	4.0	8.8	1.0	-2.4	-3.0	-2.4	-1.7	-0.3
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.4	0.3	-0.5	0.0	-1.1	0.7	1.2
Supplements: Fish oil (including cod liver oil)	10.7	14.0	29.4	5.4	-4.0	-0.5	-2.1	3.3	4.9
High cholesterol (Self-reported)	0.5	0.9	4.0	0.5	-0.7	-0.4	-2.0	-0.2	0.7
Medication: Bendroflumethiazide	3.4	5.1	11.8	1.4	-2.6	-2.9	-3.4	-1.1	1.0
Medication: Paracetamol	0.5	0.8	2.3	-0.8	1.1	0.3	1.5	0.3	-0.5
Medication: Lisinopril	0.4	0.5	1.4	-1.2	0.8	0.1	0.0	-0.8	-0.1
Medication: Atorvastatin	0.5	0.6	2.0	0.7	-0.2	-0.8	-1.4	-0.3	0.6
Illnesses of father: High blood pressure	4.0	5.0	16.4	1.8	-2.7	-4.0	-1.5	-0.8	0.7
Alcohol drinker status: Never	2.0	2.4	6.6	1.2	-0.9	0.0	-0.2	2.4	2.6
Ever smoked	1.4	2.5	7.4	-1.0	1.2	-0.5	0.6	-2.7	-2.2
Basal metabolic rate	0.4	2.3	4.8	-0.9	0.4	-2.0	0.4	-2.0	-2.2
Leg fat percentage (left)	1.3	4.6	8.4	-2.5	2.4	2.9	2.0	0.5	-1.6
Arm fat-free mass (left)	0.5	2.6	5.7	-0.9	0.5	-2.0	0.6	-2.4	-2.2
Number of operations (self-reported)	0.5	0.8	2.5	0.8	-1.1	-1.6	0.3	-0.5	0.0
Average weekly beer plus cider intake	2.5	3.6	9.0	-2.0	0.9	-0.9	0.0	-3.0	-2.6
Irritability	2.4	4.1	11.4	-3.4	1.9	1.0	1.4	-1.7	-2.0
Risk taking	1.4	2.0	4.4	1.2	-1.3	0.8	1.1	2.1	1.6
Ever had prostate specific antigen (PSA) test	1.1	1.3	4.0	2.0	-1.4	-0.4	0.2	0.5	1.2
Fractured/broken bones in last 5 years	1.4	1.8	3.7	1.8	-1.9	-0.6	-1.3	0.2	1.3
Age started oral contraceptive pill	2.6	3.2	7.7	2.1	-1.4	0.5	-1.9	1.1	2.8
Diastolic blood pressure, automated reading	2.2	6.9	20.3	0.0	-2.2	-4.5	-2.2	-2.6	-2.2
Ever depressed for a whole week	0.9	1.1	2.2	-1.5	1.1	0.9	1.3	-0.6	-0.0
Unable to work because of sickness or disability	0.1	0.2	1.0	-1.0	0.0	0.0	-0.3	0.3	-0.0
Commuting to job workplace: Cycle	0.5	0.6	1.5	0.6	1.2	1.0	0.8	0.5	0.0
Myopia	3.5	5.0	13.5	0.5	1.4	3.2	0.5	3.7	1.9
Vascular/heart problems diagnosed by doctor	2.0	5.5	14.5	-1.4	3.1	3.8	2.4	0.9	-0.3
Cholesterol lowering medication	0.6	0.8	2.8	0.2	-0.4	-0.4	-1.7	-1.2	0.4
Medication: Omeprazole (e.g. Zanprol)	2.5	3.0	6.5	2.6	-2.0	-1.6	-1.2	0.8	1.7
Pain experienced in last month	0.3	0.6	1.3	-0.7	1.0	1.1	0.8	-0.1	-0.4
Supplements: Calcium	2.7	3.0	6.5	2.5	-1.8	-0.2	-1.9	1.1	1.9
Basal cell carcinoma (self-reported)	1.0	1.2	3.0	0.9	-0.3	1.0	0.6	1.3	1.7
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.9	0.1	-0.8	-0.7	-0.0	-0.4	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.5	-0.3	-0.2	0.2	0.6	-0.7	-0.1
Heart disease (siblings)	0.6	0.7	1.7	-0.8	1.3	-0.3	-0.0	-0.9	-1.0
Alcohol drinker status: Previous	2.8	3.2	9.3	2.0	-3.0	-2.2	-0.8	-0.4	0.4
Pack years of smoking	2.9	4.2	6.7	-2.4	2.6	0.8	1.6	-1.8	-2.6
Impedance of whole body	0.6	2.9	6.8	-1.9	2.4	2.6	0.4	1.2	-0.1
Leg fat mass (left)	1.1	4.5	7.8	-2.8	2.5	1.6	1.8	-0.5	-2.6
Arm predicted mass (left)	0.5	2.4	5.4	-0.8	0.5	-2.0	0.5	-2.3	-2.0