TWAS hub - MDM4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0890	0.0330	0.00330	0.022	NA	0.023	NA	0.024	6.0e-03	NA	5.1e-03	NA	4.3e-03
2	GTEx	Colon Sigmoid	0.2130	0.0800	0.00560	-0.002	NA	0.050	NA	0.015	4.1e-01	NA	7.4e-03	NA	9.2e-02
3	GTEx	Esophagus Muscularis	0.1400	0.0440	0.00040	0.045	NA	0.018	NA	0.046	9.4e-04	NA	2.8e-02	NA	8.6e-04
4	GTEx	Nerve Tibial	0.1136	0.0441	0.00250	0.087	NA	0.022	NA	0.068	1.0e-06	NA	1.0e-02	NA	1.6e-05
5	GTEx	Testis	0.1450	0.0570	0.00430	0.003	NA	-0.006	NA	0.008	2.2e-01	NA	9.3e-01	NA	1.4e-01
6	GTEx	Uterus	0.5140	0.1310	0.00530	-0.015	NA	-0.014	NA	-0.011	8.8e-01	NA	7.7e-01	NA	6.2e-01
7	YFS	Blood	0.1195	0.0216	0.00000	0.083	0.104	0.107	0.118	0.108	1.0e-25	4.3e-32	3.7e-33	2e-36	1.9e-33
8	TCGA	Breast Invasive Carcinoma	0.0216	0.0115	0.00570	-0.001	0.004	0.005	NA	0.000	6.3e-01	3.9e-02	2.4e-02	NA	3.0e-01
9	TCGA	Brain Lower Grade Glioma	0.0234	0.0130	0.00930	0.031	0.011	0.026	NA	0.025	1.7e-04	1.6e-02	5.5e-04	NA	7.3e-04
10	TCGA	Skin Cutaneous Melanoma	0.5260	0.1410	0.00290	0.010	0.016	0.032	NA	0.054	1.6e-01	1.2e-01	4.8e-02	NA	1.5e-02
11	TCGA	Thyroid Carcinoma	0.0490	0.0220	0.00014	0.055	0.032	0.035	NA	0.037	4.2e-06	3.7e-04	2.4e-04	NA	1.6e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Prostate Cancer	19.3	27.2	52.3	-6.3	-1.8	-6.6	-6.4	-2.5	1.1	6.4	-2.6	-7.2	-4.9	-6.4
Lung cancer (father)	7.3	8.6	16.8	3.7	1.1	3.6	3.7	1.4	0.0	-3.5	0.7	4.1	2.7	3.7
Peak expiratory flow (PEF)	7.2	16.7	31.7	-4.9	-1.2	-5.6	-4.8	-2.0	-0.9	4.9	-2.5	-5.1	-4.4	-4.8
Eye problems/disorders: Diabetes related eye disease	7.0	7.7	13.8	3.7	1.8	3.4	3.7	1.7	0.7	-2.7	0.2	3.1	3.0	3.7
Illnesses of father: High blood pressure	6.9	8.5	16.6	-3.2	-1.3	-3.4	-3.3	-0.5	-0.9	4.0	-1.7	-4.1	-3.4	-3.3
Forced vital capacity (FVC), Best measure	6.4	23.5	43.4	-5.7	-3.5	-6.2	-5.6	-1.7	-0.1	6.6	-3.7	-5.2	-4.9	-5.6
Lung FVC	6.3	32.1	64.4	-6.6	-2.7	-6.9	-6.7	-0.1	-1.3	8.0	-2.4	-7.0	-6.7	-6.7
High blood pressure (mother)	6.3	8.8	17.8	-3.6	-0.8	-3.6	-3.7	-2.0	-0.4	2.6	-2.8	-4.2	-2.5	-3.7
Forced vital capacity (FVC)	6.1	23.3	37.5	-5.7	-4.0	-6.1	-5.6	-2.2	-0.3	6.1	-3.2	-5.5	-5.1	-5.6
Myopia	6.0	8.7	18.8	3.5	2.3	3.0	3.6	4.3	0.3	-1.3	2.9	3.5	1.4	3.6
Relative age of first facial hair	5.9	12.1	20.6	-4.5	-3.1	-4.0	-4.5	-2.6	-0.4	3.2	-0.9	-4.3	-3.1	-4.5
Forced expiratory volume in 1-second (FEV1)	4.8	16.3	30.2	-4.8	-2.4	-5.2	-4.7	-1.5	-0.2	5.5	-2.6	-4.6	-4.3	-4.7
Forced expiratory volume in 1-second (FEV1), Best measure	4.7	15.0	34.8	-4.5	-1.8	-5.1	-4.5	-0.6	0.3	5.9	-2.7	-4.1	-3.9	-4.5
Illnesses of father: None of the above (group 1)	4.6	5.6	9.6	3.0	-1.2	2.7	3.1	0.4	-1.5	-3.0	1.4	2.9	1.9	3.1
Diabetes (self-reported)	4.3	6.6	14.7	2.7	1.4	3.0	2.8	-0.6	1.3	-3.6	1.1	2.7	3.8	2.8
Respiratory disease	4.1	9.0	15.3	-3.9	-2.1	-3.6	-3.8	-2.8	-1.3	2.0	-1.8	-3.0	-3.4	-3.8
Schizophrenia (2014)	3.8	8.5	18.9	-3.6	0.1	-4.0	-3.6	-1.2	0.3	2.8	-1.0	-3.1	-4.3	-3.6
Bipolar Disorder or Schizophrenia	3.6	8.7	18.7	-3.7	-1.7	-3.9	-3.6	-1.7	-0.0	2.4	-1.4	-2.9	-4.3	-3.6
Schizophrenia (2018)	3.6	7.4	17.9	-3.3	-0.8	-3.5	-3.3	-1.0	0.2	2.8	-0.4	-3.0	-4.2	-3.3
Qualifications: College or University degree	3.5	11.0	34.7	-3.2	-2.1	-3.4	-3.0	2.9	-0.4	5.9	1.3	-3.0	-4.9	-3.0
Medication: Bendroflumethiazide	3.5	5.3	9.8	-2.5	-1.9	-2.4	-2.6	-0.8	-2.9	2.4	-1.8	-3.1	-1.0	-2.6
Diabetes diagnosed by doctor	3.3	5.5	14.4	2.3	1.3	2.7	2.3	-0.3	2.1	-3.0	1.5	2.4	3.8	2.3
Illnesses of father: Heart disease	3.2	4.4	8.9	-2.1	1.5	-2.3	-2.1	-0.8	1.6	2.4	-1.3	-2.7	-3.0	-2.1
Medication: Aspirin	3.1	4.1	7.5	-2.3	0.3	-2.4	-2.4	-0.8	1.4	1.3	-2.7	-2.6	-2.1	-2.4
Ovarian Cancer	3.0	3.9	7.3	-2.3	-1.8	-2.5	-2.4	-0.8	-1.0	2.0	0.1	-2.7	-2.1	-2.4
High blood pressure (siblings)	2.9	4.2	7.8	-2.3	-1.1	-2.7	-2.2	-1.4	0.3	2.5	-1.9	-1.9	-2.8	-2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.9	6.0	13.1	-2.9	0.3	-3.1	-3.0	0.7	0.3	3.6	-1.3	-3.2	-2.1	-3.0
Supplements: Fish oil (including cod liver oil)	2.9	3.7	13.8	-0.8	0.3	-0.7	-0.8	3.7	-0.6	3.6	2.6	-0.9	-1.9	-0.8
High blood pressure	2.8	7.8	16.7	-3.2	-0.3	-3.4	-3.4	-0.6	-1.1	2.9	-2.9	-4.1	-2.4	-3.4
Medication: Lansoprazole	2.8	3.2	6.6	-1.6	-0.1	-2.6	-1.6	-1.9	0.6	1.8	-1.5	-2.4	-2.4	-1.6
LDL Cholesterol	2.7	4.3	7.5	2.6	0.8	2.7	2.6	0.5	-1.0	-2.6	-0.5	2.4	2.2	2.6
Hand grip strength (left)	2.7	7.1	15.6	-2.8	0.5	-3.6	-2.8	-1.2	0.7	4.0	-1.0	-3.3	-3.3	-2.8
Hayfever/allergic rhinitis (self-reported)	2.7	3.6	7.9	-2.2	-0.0	-2.2	-2.4	0.0	-0.4	2.4	-0.9	-2.8	-2.0	-2.4
Chest pain or discomfort	2.7	3.9	6.6	-2.6	-0.7	-2.5	-2.5	-1.8	0.9	1.0	-1.9	-2.4	-1.7	-2.5
Hypertension (Self-reported)	2.7	7.4	15.5	-3.1	-0.5	-3.2	-3.3	-0.9	-1.8	2.4	-3.3	-3.9	-2.1	-3.3
Vascular/heart problems diagnosed by doctor	2.7	7.3	15.7	3.2	-0.1	3.2	3.4	0.9	0.5	-2.5	2.9	4.0	2.2	3.4
Relative age voice broke	2.6	4.0	7.2	-2.6	-2.7	-2.1	-2.6	-2.1	-0.0	1.6	-0.2	-1.8	-1.3	-2.6
Ever highly irritable/argumentative for 2 days	2.6	3.1	7.8	2.1	2.8	1.7	2.0	0.1	1.3	-2.0	0.8	1.4	1.6	2.0
Breast Cancer	2.5	6.0	13.2	-3.2	-0.4	-2.7	-3.3	-0.6	0.2	2.3	-1.2	-3.6	-2.5	-3.3
Hand grip strength (right)	2.5	6.7	14.1	-2.8	-1.1	-3.6	-2.7	-1.4	0.7	3.8	-1.3	-3.0	-3.1	-2.7
Medication: Atenolol	2.5	3.1	4.9	-2.1	-0.2	-2.1	-2.2	-2.2	1.2	0.9	-2.2	-1.9	-0.4	-2.2
Exposure to tobacco smoke outside home	2.5	3.4	9.0	1.8	1.8	2.3	1.7	0.8	3.0	-0.9	1.9	1.9	1.3	1.7
Shortness of breath walking on level ground	2.5	2.9	7.0	-1.9	-2.2	-1.6	-1.9	-2.6	0.4	-0.5	-0.9	-1.7	-1.7	-1.9
Diastolic blood pressure, automated reading	2.5	7.6	16.5	-3.5	0.8	-3.0	-3.8	-1.8	-1.9	2.4	-1.3	-4.1	-1.4	-3.8
Fluid intelligence score	2.4	5.1	10.1	-2.5	-1.9	-2.8	-2.5	-0.7	-0.4	3.2	-1.2	-2.5	-2.7	-2.5
Type 2 Diabetes (T2D) (2018)	2.3	4.2	10.4	1.9	0.0	2.4	1.9	-0.8	1.4	-2.7	2.1	2.2	3.2	1.9
Other serious medical condition/disability diagnosed by doctor	2.3	3.0	8.2	-1.8	0.7	-2.4	-1.7	-0.2	1.1	2.0	-1.5	-1.6	-2.9	-1.7
Medication: Metformin	2.3	3.2	9.7	1.5	1.3	2.2	1.5	-0.2	0.8	-3.1	1.3	2.2	2.3	1.5
Maternal smoking around birth	2.3	3.4	12.6	-0.8	-1.5	-0.8	-0.8	-3.5	-0.3	-2.0	-3.5	0.2	1.9	-0.8
Alcohol drinker status: Previous	2.3	2.6	4.9	-1.9	0.5	-2.0	-2.0	-0.3	1.5	2.1	-0.8	-2.2	-0.8	-2.0
Asthma	2.2	4.4	7.3	-2.7	-2.0	-2.5	-2.6	-1.6	-1.7	1.1	-1.6	-2.1	-1.8	-2.6
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.6	4.7	-2.2	-1.1	-1.8	-2.1	-0.5	-0.5	1.6	-1.5	-1.1	-1.9	-2.1
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.6	10.8	-2.2	-3.3	-2.3	-2.0	-1.8	-1.4	1.8	-2.7	-1.6	-2.0	-2.0
Medication: Aspirin	2.2	2.9	8.2	-1.8	0.7	-1.8	-1.8	-1.2	1.5	0.4	-2.9	-2.2	-1.3	-1.8
Leg fat percentage (left)	2.2	7.9	14.2	3.4	3.8	3.3	3.4	0.5	2.0	-2.9	0.4	3.0	2.5	3.4
Verbal and Numeric Reasoning (VNR)	2.1	5.0	11.1	-2.4	-1.9	-2.9	-2.3	0.1	-0.8	3.3	-0.7	-1.9	-3.3	-2.3
Crohns Disease (2012)	2.1	3.3	6.5	2.0	2.1	1.8	2.2	0.3	0.8	-1.1	2.4	2.5	1.4	2.2
Rheumatoid Arthritis	2.1	2.8	7.8	2.0	0.4	2.2	1.9	-0.3	-0.5	-2.2	0.1	1.5	2.8	1.9
Hayfever, allergic rhinitis or eczema	2.1	4.6	10.5	-2.4	-1.9	-2.3	-2.4	0.6	-1.3	2.7	0.0	-2.2	-3.2	-2.4
Allergy	2.1	4.8	8.4	2.7	1.4	2.7	2.6	0.8	1.4	-2.0	1.0	2.6	2.9	2.6
Leg fat percentage (right)	2.1	7.5	13.8	3.3	3.7	3.1	3.2	0.4	1.6	-3.0	0.5	2.8	2.7	3.2
Blood Eosinophil Count	2.0	15.4	28.5	-5.0	-2.3	-4.5	-5.1	-5.0	-0.1	1.4	-2.9	-5.3	-1.9	-5.1
Financial difficulties in last 2 years	2.0	2.7	11.4	0.9	0.0	1.2	0.6	-1.8	-0.2	-2.5	-2.3	-0.1	3.4	0.6
Pulse wave peak to peak time	2.0	2.3	4.7	-1.5	-1.9	-2.1	-1.4	-0.6	-1.2	2.2	-1.1	-1.5	-1.2	-1.4
Medication: Blood pressure	2.0	3.8	9.6	-2.3	-1.5	-2.0	-2.3	-0.8	-2.3	1.5	-1.4	-3.1	-0.7	-2.3
Cardiovascular Disease	1.9	6.2	14.4	-2.8	-0.3	-2.7	-2.9	-1.5	-1.4	2.0	-3.0	-3.8	-2.0	-2.9
Ever used hormone-replacement therapy (HRT)	1.9	2.5	4.2	-2.0	1.5	-1.5	-2.0	-1.9	-1.4	0.2	0.0	-1.8	-1.2	-2.0
Medication: Blood pressure	1.9	3.3	6.0	-2.3	-0.7	-2.4	-2.3	0.0	-0.8	2.2	-0.8	-2.0	-2.1	-2.3
Knee pain experienced in last month	1.9	3.0	5.3	-2.2	-1.2	-2.2	-2.2	-2.3	-0.4	1.0	-1.2	-2.0	0.5	-2.2
Qualifications: nursing, teaching	1.9	2.9	10.9	-0.7	-0.4	-1.5	-0.7	2.5	-0.2	3.3	1.2	-0.8	-3.0	-0.7
Osteoporosis (self-reported)	1.9	2.4	4.8	2.1	2.2	1.5	2.1	1.2	-0.3	-0.5	-0.3	1.6	1.2	2.1
Major Depression (MDD)	1.8	2.2	4.7	-1.4	-0.6	-1.9	-1.3	-2.1	0.1	1.2	-1.8	-1.3	-2.2	-1.3
Fasting Glucose	1.8	2.2	3.8	2.0	0.1	1.8	1.9	-0.5	-1.6	-1.2	0.7	1.3	1.7	1.9
Lung FEV1/FVC ratio	1.8	9.1	18.7	3.3	3.2	3.2	3.2	4.3	0.5	-0.9	3.4	3.0	2.7	3.2
Taking other prescription medications	1.8	2.7	5.9	-1.8	-0.3	-2.0	-1.9	-1.4	-0.9	0.8	-2.1	-2.4	-1.5	-1.9
Qualifications: None of the above	1.8	3.9	13.9	2.0	2.2	2.0	1.9	-1.4	0.1	-3.7	-0.6	1.5	2.2	1.9
Body fat percentage	1.8	7.2	10.7	3.2	3.1	3.0	3.3	0.1	2.2	-3.1	0.3	3.0	2.4	3.3
Number of children fathered	1.8	2.1	5.6	-1.3	1.3	-1.4	-1.2	1.9	0.7	2.4	-0.1	-0.9	-2.0	-1.2
Ever taken oral contraceptive pill	1.8	2.0	4.1	-1.5	-1.9	-1.4	-1.5	-1.4	0.7	1.0	-0.8	-2.0	-1.1	-1.5
Number of operations (self-reported)	1.8	2.7	5.5	-2.2	0.3	-2.3	-2.1	-0.6	0.0	2.0	-0.5	-1.6	-1.9	-2.1
Average weekly beer plus cider intake	1.8	2.6	12.6	-1.0	-1.5	0.0	-1.1	-3.5	-0.6	-1.8	-2.4	-0.9	0.5	-1.1
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	8.3	-1.5	-0.5	-1.6	-1.5	1.2	-0.0	2.9	-0.2	-1.2	-2.0	-1.5
Pack years adult smoking proportion	1.7	2.6	9.9	0.9	-1.0	1.4	0.9	-2.1	0.4	-3.1	-1.2	1.0	2.6	0.9
Had other major operations	1.7	2.1	4.3	-2.1	0.8	-1.9	-2.1	-0.2	0.5	1.5	0.6	-1.4	-0.7	-2.1
Heart attack	1.7	2.1	9.0	-1.4	1.6	-1.3	-1.5	-0.6	3.0	0.5	-1.1	-1.2	-0.3	-1.5
Illnesses of siblings	1.7	2.3	3.9	1.8	-0.1	2.0	1.8	0.7	0.1	-1.8	1.3	1.7	1.9	1.8
Time employed in main current job	1.7	1.9	4.1	-2.0	-0.5	-1.7	-2.0	0.2	-1.4	1.3	-0.1	-1.2	-1.1	-2.0
Breastfed as a baby	1.7	2.2	4.7	-1.3	-1.3	-1.6	-1.3	0.5	-1.1	1.7	-2.2	-1.4	-1.8	-1.3
Migraine (self-reported)	1.7	2.2	7.6	-1.3	-1.3	-1.2	-1.3	1.4	-0.8	2.7	0.3	-1.1	-2.1	-1.3
Heart disease (mother)	1.7	2.0	5.0	-1.1	0.3	-1.7	-1.1	0.3	1.7	2.2	-1.2	-1.3	-2.2	-1.1
Medication: Gliclazide	1.7	1.9	5.6	1.1	2.2	1.0	1.1	0.4	1.5	-1.4	0.2	0.9	2.4	1.1
Medication: Ramipril	1.6	2.1	4.6	-1.6	-0.8	-1.8	-1.8	-0.4	-1.5	1.2	-0.7	-2.1	-1.2	-1.8
Worrier / anxious feelings	1.6	2.9	5.1	2.1	1.6	2.2	2.0	0.8	-0.3	-2.3	0.6	1.7	1.7	2.0
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	7.4	-1.2	-1.0	-1.7	-1.1	0.2	-0.3	2.0	-0.7	-0.8	-2.7	-1.1
Medication: Seretide 50 evohaler	1.6	1.9	3.1	-1.6	-1.4	-1.8	-1.7	-1.3	-1.1	0.7	0.1	-1.4	-1.5	-1.7
Asthma (self-reported)	1.6	3.3	5.5	-2.4	-1.7	-2.2	-2.3	-1.5	-1.7	0.7	-1.2	-1.7	-1.6	-2.3
Number of self-reported non-cancer illnesses	1.6	2.8	5.1	-1.8	1.3	-2.3	-1.8	-0.5	-1.5	1.6	-2.1	-2.1	-0.8	-1.8
Commuting to job workplace: Public transport	1.6	1.9	3.2	1.8	1.8	1.2	1.8	1.5	1.1	-0.4	0.3	1.5	0.8	1.8
Supplements: Calcium	1.6	1.7	4.1	-0.7	-1.4	-0.7	-0.6	1.9	-1.9	2.0	1.7	-0.4	-0.8	-0.6
Intelligence (Savage-Jansen 2018)	1.5	4.7	13.3	-2.3	-1.5	-2.3	-2.3	1.2	-0.3	3.6	-0.3	-1.7	-3.2	-2.3
Worry (Nagel 2018)	1.5	3.2	7.1	2.2	1.3	2.1	2.2	0.4	1.1	-2.7	0.4	2.0	1.5	2.2
Allergy or Eczema	1.5	4.1	8.0	-2.2	-1.9	-2.2	-2.1	0.3	-1.6	2.7	0.1	-2.0	-2.8	-2.1
Trunk fat percentage	1.5	6.2	9.0	2.9	2.8	2.5	3.0	-0.3	2.4	-2.9	0.2	2.9	2.1	3.0
Arm fat percentage (right)	1.5	5.9	9.5	3.0	3.1	2.8	3.0	0.3	2.0	-2.7	0.2	2.2	2.2	3.0
Trunk fat-free mass	1.5	8.5	12.6	-3.5	-1.6	-3.1	-3.4	-2.3	2.2	3.1	-2.5	-3.0	-3.2	-3.4
Mouth/teeth dental problems: Dentures	1.5	2.6	5.1	1.8	-0.3	2.1	1.8	1.0	-0.8	-2.2	1.3	1.6	1.9	1.8
Pulse wave Arterial Stiffness index	1.5	1.7	3.9	1.2	1.8	1.7	1.1	0.2	1.5	-2.0	0.7	1.1	0.8	1.1
Trunk predicted mass	1.5	8.3	12.3	-3.5	-1.6	-3.0	-3.4	-2.3	2.2	3.0	-2.6	-3.0	-3.1	-3.4
Comparative body size at age 10	1.5	4.1	7.6	-2.5	-1.5	-2.5	-2.6	-0.9	1.2	2.5	-0.6	-2.8	-0.9	-2.6
Number of full brothers	1.5	1.8	3.1	-1.8	-0.9	-1.6	-1.7	-1.1	0.5	1.4	1.1	-1.5	-0.7	-1.7
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	5.5	1.2	-1.0	1.5	1.1	-0.0	-0.0	-2.3	0.4	1.4	2.1	1.1
Average weekly red wine intake	1.5	2.2	7.7	-0.8	-0.7	-1.4	-0.5	2.2	-0.1	2.8	2.0	-0.5	-1.9	-0.5
Ever had bowel cancer screening	1.5	1.7	5.2	-1.0	1.5	-1.6	-1.0	0.3	1.1	2.3	-0.0	-1.3	-1.5	-1.0
Heart attack/myocardial infarction (self-reported)	1.5	1.9	8.5	-1.4	1.6	-1.2	-1.4	-0.5	2.9	0.4	-1.0	-1.1	-0.2	-1.4
Bipolar Disorder (2018)	1.4	2.2	3.4	-1.8	-1.8	-1.8	-1.7	-1.5	-0.3	0.4	-1.6	-1.0	-1.7	-1.7
HbA1C	1.4	1.5	3.2	1.5	1.6	1.4	1.5	-0.1	0.8	-0.0	-0.1	1.4	1.8	1.5
Hearing difficulty/problems: Yes	1.4	2.1	6.3	-1.7	0.2	-1.6	-1.7	-2.5	0.4	-0.4	-1.4	-1.4	-1.2	-1.7
Illnesses of mother	1.4	1.7	8.2	1.0	0.3	1.2	1.1	0.8	-0.2	-1.1	2.9	1.6	0.7	1.1
Medication: Amlodipine	1.4	2.0	4.4	-1.6	-0.4	-1.9	-1.7	-0.4	0.2	1.6	-1.0	-2.1	-0.7	-1.7
Wheeze or whistling in the chest in last year	1.4	2.4	5.3	-1.8	-1.1	-1.8	-1.9	-1.9	-0.4	-0.4	-1.5	-2.3	-0.8	-1.9
Arm fat percentage (left)	1.4	5.5	10.2	2.8	3.2	2.5	2.8	-0.2	2.2	-2.6	-0.3	2.1	2.0	2.8
Handedness (chirality/laterality): Left-handed	1.4	1.7	3.5	1.2	1.9	0.7	1.4	1.2	1.3	-0.3	1.8	1.8	-0.4	1.4
Mineral and other dietary supplements	1.4	1.9	10.4	0.1	0.1	0.1	0.1	-3.2	1.0	-2.5	-1.4	0.2	1.2	0.1
Hearing aid user	1.4	1.5	3.1	-1.3	-0.8	-1.2	-1.3	-0.5	-1.8	0.0	-1.5	-1.1	-1.7	-1.3
Pack years of smoking	1.4	2.1	7.7	0.7	-0.9	1.2	0.7	-1.8	0.8	-2.8	-1.2	0.9	2.4	0.7
Depressed Affect (Nagel 2018)	1.3	2.8	12.8	0.9	1.3	1.1	0.8	-2.0	3.6	-2.5	-0.5	0.6	1.4	0.8
Height	1.3	25.2	41.5	-6.4	-3.6	-5.8	-6.2	-2.4	4.5	5.6	-3.1	-5.0	-4.5	-6.2
Fed-up feelings	1.3	2.3	5.5	0.8	1.6	0.9	0.7	-2.3	2.0	-2.3	-1.4	0.1	2.0	0.7
Qualifications: CSEs or equivalent	1.3	1.8	3.3	1.4	1.8	1.7	1.2	0.4	1.1	-0.9	-0.4	1.6	1.8	1.2
Past tobacco smoking	1.3	2.4	6.5	2.0	0.9	1.6	1.9	2.5	-1.0	0.5	1.2	1.7	-0.2	1.9
Number of live births	1.3	1.8	5.4	1.1	2.3	1.3	1.0	2.2	1.1	0.3	1.3	1.3	0.5	1.0
Length of working week for main job	1.3	1.5	6.8	0.3	0.9	0.2	0.3	2.6	-0.6	2.0	1.9	-0.1	-0.8	0.3
Loud music exposure frequency	1.3	1.4	4.2	1.3	-0.7	1.2	1.4	0.2	-0.8	-1.3	0.5	2.0	0.9	1.4
Glaucoma (self-reported)	1.3	1.5	3.0	1.6	0.1	1.2	1.6	1.7	-0.2	0.0	1.5	1.4	0.4	1.6
Medication: Omeprazole	1.3	1.6	5.8	-1.2	-0.8	-1.0	-1.2	1.4	-0.7	2.4	-0.2	-0.8	-1.6	-1.2
Neuroticism	1.2	2.8	8.4	1.7	0.6	1.8	1.6	-1.1	2.0	-2.9	-0.0	1.6	1.8	1.6
Number of treatments/medications taken	1.2	2.1	3.7	-1.8	0.0	-1.9	-1.8	0.0	0.3	1.8	-1.1	-1.9	-1.4	-1.8
Sitting height	1.2	8.4	12.6	-3.2	-2.4	-2.9	-3.0	-3.3	2.7	2.2	-3.5	-2.5	-2.8	-3.0
Alcohol usually taken with meals	1.2	1.9	9.4	0.5	1.4	-0.0	0.5	3.1	0.7	2.0	1.8	0.4	-1.1	0.5
Father’s age at death	1.2	1.6	5.5	-1.5	-1.2	-1.2	-1.4	-1.0	0.6	0.2	-0.9	-0.6	-2.4	-1.4
Qualifications: A levels/AS levels or equivalent	1.2	2.6	8.1	-1.2	-1.9	-1.3	-1.2	1.2	-0.2	2.9	-0.1	-1.7	-2.5	-1.2
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	3.8	1.7	0.6	2.0	1.8	0.2	1.0	-1.8	-0.2	1.3	1.5	1.8
Smoking status: Previous	1.2	1.8	3.4	-1.9	-0.2	-1.8	-1.7	-1.5	0.8	0.7	-1.0	-1.5	-0.4	-1.7
Whole body fat-free mass	1.2	6.9	9.5	-3.1	-1.3	-2.7	-3.0	-2.2	2.5	2.7	-2.2	-2.6	-3.0	-3.0
Whole body water mass	1.2	6.9	9.6	-3.1	-1.3	-2.7	-3.0	-2.1	2.6	2.8	-2.1	-2.6	-3.0	-3.0
Miserableness	1.2	2.1	10.6	-0.4	1.0	-0.2	-0.5	-3.3	1.9	-1.6	-1.9	-0.7	0.6	-0.5
Neuroticism (Nagel 2018)	1.1	2.7	8.4	1.4	1.3	1.6	1.3	-0.9	2.9	-2.6	-0.6	1.0	1.4	1.3
Crohns Disease (2017)	1.1	2.3	4.7	1.7	1.9	1.7	1.8	0.1	0.1	-1.2	1.6	2.2	1.1	1.8
Average weekly spirits intake	1.1	1.4	2.7	1.5	0.3	1.6	1.5	0.9	-0.3	-1.3	-0.9	1.2	0.7	1.5
Diabetes (father)	1.1	1.4	4.7	1.1	1.7	1.1	1.1	-0.6	2.2	-0.6	0.8	1.3	0.6	1.1
Neuroticism score	1.1	2.3	7.7	1.4	1.4	1.5	1.3	-1.3	1.6	-2.8	-0.1	0.9	1.4	1.3
Medication: Allopurinol	1.1	1.5	4.1	1.0	2.0	1.1	0.9	1.1	1.6	-0.6	-1.7	0.4	1.2	0.9
Arm predicted mass (right)	1.1	5.6	8.0	-2.8	-0.9	-2.4	-2.7	-2.5	2.5	2.0	-2.3	-2.1	-2.7	-2.7
Ever smoked	1.1	2.0	7.7	-1.4	-1.7	-1.0	-1.3	-2.8	0.6	-1.5	-1.1	-0.8	0.7	-1.3
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.2	-1.1	-0.0	-1.1	-1.0	0.7	1.5	1.6	0.1	-1.1	-1.8	-1.0
Age started oral contraceptive pill	1.1	1.3	5.6	-0.0	-0.4	-0.2	0.1	2.1	-1.6	0.8	2.4	0.9	-0.7	0.1
Alzheimer’s Disease (including proxy)	1.0	1.5	2.7	1.6	-0.6	1.2	1.6	0.7	0.6	-0.9	0.6	1.3	1.6	1.6
Bipolar Disorder (2011)	1.0	1.0	2.0	-1.0	-1.3	-1.4	-1.0	-0.2	0.4	0.9	-1.2	-0.7	-1.1	-1.0
Chronotype (morning person)	1.0	2.3	5.8	1.9	-0.8	1.5	2.0	1.0	0.0	-1.7	-0.2	2.4	1.4	2.0
Serious illness, injury or assault to yourself	1.0	1.2	5.6	-0.2	2.4	-0.4	-0.3	0.5	-0.4	1.0	-0.4	-1.1	-2.1	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	6.4	-1.0	-0.7	-1.1	-1.1	-2.5	0.3	-0.2	-2.0	-1.1	-0.9	-1.1
Arm fat-free mass (right)	1.0	5.4	7.4	-2.7	-0.9	-2.4	-2.5	-2.7	2.5	1.9	-2.4	-1.9	-2.5	-2.5
Number of full sisters	1.0	1.2	3.6	0.9	1.9	0.7	0.9	1.6	1.0	0.3	0.9	0.3	1.5	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	1.9	-1.3	-1.0	-1.3	-1.3	-1.1	-0.9	0.4	-1.4	-1.1	-0.1	-1.3
Leg predicted mass (right)	1.0	5.5	8.8	-2.6	-0.8	-2.4	-2.5	-2.0	2.9	2.4	-1.8	-2.0	-3.0	-2.5
Average weekly champagne plus white wine intake	1.0	1.3	4.7	-0.1	0.4	0.2	-0.1	2.2	0.8	1.6	2.1	-0.2	-1.3	-0.1
Impedance of whole body	1.0	5.1	10.1	2.8	0.6	2.3	2.9	0.7	-1.0	-2.4	0.8	2.9	3.2	2.9
Mean Putamen Volume	0.9	1.0	1.5	-1.2	0.8	-1.0	-1.2	0.3	0.6	1.2	-1.2	-1.1	-0.8	-1.2
Smoking Status	0.9	2.1	5.5	-1.2	-1.4	-0.3	-1.4	-2.3	0.1	-2.0	-0.4	-1.3	1.9	-1.4
Supplements: Zinc	0.9	1.0	3.9	-0.9	-1.1	-0.6	-0.9	0.8	-0.1	1.5	2.0	-0.1	-0.4	-0.9
Current tobacco smoking	0.9	1.5	4.7	0.0	-1.8	0.7	-0.2	-1.8	-0.8	-2.2	-0.1	-0.6	1.9	-0.2
Impedance of leg (left)	0.9	4.6	9.4	2.5	0.4	2.4	2.5	1.0	-1.2	-2.3	0.7	2.9	3.1	2.5
Leg predicted mass (left)	0.9	4.6	8.5	-2.3	-0.6	-2.2	-2.2	-2.2	2.9	2.0	-1.7	-1.9	-2.5	-2.2
Had menopause	0.9	1.2	3.1	0.8	1.6	0.6	0.9	1.8	-1.4	0.0	1.1	1.0	0.6	0.9
Impedance of arm (right)	0.9	4.2	7.1	2.6	0.3	2.2	2.7	1.5	-0.7	-1.9	1.4	2.4	2.6	2.7
Alcohol intake versus 10 years previously	0.9	1.3	5.7	0.5	-0.4	0.6	0.4	-1.8	-0.5	-1.6	-1.1	0.2	2.4	0.4
Standing height	0.9	9.1	13.7	-3.7	-3.1	-3.4	-3.4	-2.1	2.3	3.5	-2.1	-2.5	-3.1	-3.4
Age at first live birth	0.9	1.7	4.4	-1.5	-2.1	-1.6	-1.4	-0.1	-0.4	1.1	-0.9	-0.7	-1.5	-1.4
Overall health rating	0.9	2.0	5.6	-0.1	2.4	0.2	-0.1	-2.2	2.2	-1.8	-1.3	-0.4	1.1	-0.1
Leg fat-free mass (right)	0.9	5.0	8.5	-2.5	-0.7	-2.3	-2.4	-2.0	2.9	2.3	-1.8	-1.9	-2.8	-2.4
Mood swings	0.9	1.6	4.4	1.0	1.6	1.3	1.0	-0.8	2.1	-1.9	-0.5	0.5	1.1	1.0
Smoking status: Current	0.9	1.4	5.4	0.1	-1.8	0.9	-0.1	-1.6	-0.5	-2.3	-0.2	-0.4	1.8	-0.1
Wears glasses or contact lenses	0.9	1.1	3.9	-0.2	0.5	-0.3	-0.2	2.0	-1.5	1.4	1.7	-0.2	-0.8	-0.2
Alcohol drinker status: Never	0.9	1.0	6.2	0.6	0.7	0.5	0.6	2.5	-0.3	1.7	0.4	-0.1	-0.2	0.6
Fractured/broken bones in last 5 years	0.9	1.1	2.4	-1.0	1.6	-0.9	-1.1	0.5	0.0	1.3	0.3	-1.2	-1.5	-1.1
Leg fat mass (left)	0.9	3.4	8.5	1.8	2.7	1.7	1.8	-0.8	2.9	-1.9	-0.6	1.7	1.0	1.8
Arm predicted mass (left)	0.9	4.4	6.2	-2.4	-0.7	-2.0	-2.3	-2.1	2.5	1.9	-1.7	-2.0	-2.4	-2.3
Alzheimer’s Disease (in mother)	0.8	1.0	1.9	1.4	-0.9	1.0	1.4	-0.0	0.4	-1.0	0.7	0.9	1.0	1.4
Triglycerides	0.8	1.2	3.1	0.7	-1.2	0.8	0.7	-1.5	-1.3	-1.8	-1.4	0.2	1.0	0.7
Sensitivity / hurt feelings	0.8	1.4	7.7	-0.3	1.0	0.2	-0.4	-1.7	2.8	-1.4	-0.6	0.1	1.0	-0.4
Angina	0.8	1.0	3.1	-0.8	1.0	-0.7	-0.8	-1.2	1.8	-0.6	-1.4	-0.8	-0.3	-0.8
Medication for hormone replacement therapy	0.8	0.9	3.1	0.6	1.1	1.0	0.6	-0.6	-0.1	-1.8	0.7	0.6	1.5	0.6
Leg fat-free mass (left)	0.8	4.4	8.5	-2.2	-0.5	-2.1	-2.2	-2.2	2.9	1.9	-1.7	-1.9	-2.4	-2.2
Age when periods started (menarche)	0.8	2.0	3.8	-1.5	-1.7	-1.3	-1.6	-1.1	-1.6	0.9	-0.2	-1.9	-1.4	-1.6
Trunk fat mass	0.8	3.3	8.5	1.8	2.2	1.6	2.0	-0.8	2.9	-1.9	-0.5	1.9	1.2	2.0
Falls in the last year	0.8	1.1	4.7	0.0	1.1	-0.2	0.1	2.2	0.3	1.6	1.3	-0.0	-1.4	0.1
Hair/balding pattern: Pattern 3	0.8	1.2	3.9	0.6	1.0	0.0	0.7	2.0	-0.6	0.6	1.9	1.1	-1.1	0.7
Medication: Paracetamol	0.8	1.3	9.2	0.6	0.6	0.6	0.6	0.1	3.0	0.3	0.2	0.9	1.5	0.6
Angina (self-reported)	0.8	1.1	3.6	-0.7	1.5	-0.6	-0.8	-1.1	1.9	-0.6	-1.5	-0.7	-0.1	-0.8
Leg fat mass (right)	0.8	3.1	7.3	1.7	2.5	1.7	1.8	-0.8	2.7	-1.9	-0.5	1.6	1.1	1.8
Supplements: Vitamin C	0.8	1.0	5.2	-0.1	-0.4	0.1	-0.2	2.3	1.1	1.7	0.6	-0.8	0.5	-0.2
Basal metabolic rate	0.8	4.6	8.3	-2.4	-0.7	-2.1	-2.3	-2.1	2.9	2.0	-1.9	-2.0	-2.4	-2.3
Arm fat-free mass (left)	0.8	4.0	6.2	-2.4	-0.7	-1.9	-2.2	-2.2	2.5	1.7	-1.4	-1.9	-2.2	-2.2
Blood Platelet Count	0.7	8.0	27.8	-1.5	-5.3	-1.7	-1.6	-4.8	-3.1	-1.9	-2.3	-3.0	0.2	-1.6
Severe depression (siblings)	0.7	0.8	2.4	0.9	0.5	0.8	1.0	1.6	0.1	0.2	0.6	1.2	-1.0	1.0
Impedance of leg (right)	0.7	3.6	9.1	2.1	0.2	1.9	2.1	0.5	-1.4	-2.2	0.7	2.4	3.0	2.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	3.8	-0.0	1.8	0.0	-0.1	-1.5	1.9	-0.9	-0.8	-1.0	0.7	-0.1
Depression (self-reported)	0.7	0.9	8.5	0.2	0.2	0.0	0.2	-0.4	2.9	-0.2	-0.5	0.1	-0.5	0.2
Prospective memory result	0.7	0.9	3.8	0.3	0.4	0.1	0.1	-1.9	-1.2	-1.5	-1.1	-0.2	1.0	0.1
Impedance of arm (left)	0.7	3.2	6.6	2.3	0.5	1.6	2.4	0.7	-0.6	-1.8	0.4	2.2	2.6	2.4
Gout (self-reported)	0.7	1.0	4.3	0.9	2.1	0.6	0.9	1.0	0.8	-0.2	-1.0	0.5	0.9	0.9
Birth weight	0.7	1.6	9.3	-0.6	-1.4	-1.0	-0.6	1.5	-0.4	3.0	-0.5	-0.5	-1.1	-0.6
Worry too long after embarrassment	0.7	1.2	2.7	1.6	0.4	1.5	1.6	0.0	0.2	-1.5	0.7	0.9	0.4	1.6
Neck or shoulder pain in last month	0.7	0.9	4.0	-0.7	-0.2	-1.2	-0.6	0.9	0.9	2.0	0.9	-0.9	-0.6	-0.6
Whole body fat mass	0.7	3.0	7.9	1.7	2.2	1.6	1.7	-0.9	2.8	-1.8	-0.6	1.7	1.3	1.7
Commuting to job workplace: Walk	0.7	0.8	2.5	-0.2	-1.5	-0.5	-0.1	0.8	-0.9	1.6	1.2	0.2	-0.7	-0.1
Breast cancer (self-reported)	0.7	0.8	2.9	0.3	-1.7	0.9	0.3	0.7	-0.6	-1.0	1.1	1.3	0.4	0.3
Arm fat mass (left)	0.7	2.7	6.9	1.6	2.4	1.5	1.7	-0.8	2.6	-1.7	-0.4	1.4	1.1	1.7
Medication: Paracetamol	0.7	1.1	6.9	0.2	1.5	-0.0	0.3	-0.4	2.6	0.9	-0.2	0.4	1.1	0.3
Risk taking	0.7	1.0	4.4	0.3	2.1	0.7	0.3	1.7	1.0	0.7	0.8	0.6	0.3	0.3
Neuroticism (2016)	0.6	0.9	2.5	1.1	0.1	0.6	0.9	-0.9	-1.0	-1.6	0.7	-0.2	1.4	0.9
Primary Biliary Cirrhosis	0.6	0.8	6.5	0.2	2.5	-0.1	0.2	-0.2	0.7	0.0	-1.2	-0.4	-0.1	0.2
Waist Hip Ratio (WHR)	0.6	2.7	11.3	-0.1	-1.6	0.2	-0.1	-3.2	0.6	-3.4	-1.5	0.2	1.6	-0.1
Systolic blood pressure, automated reading	0.6	1.9	6.7	1.1	2.6	1.0	0.9	0.7	-2.1	-1.0	0.7	0.8	1.7	0.9
Vitamin and mineral supplements	0.6	0.9	4.0	-0.0	-0.9	0.3	-0.0	-2.0	-1.0	-1.9	0.3	0.1	0.3	-0.0
Body mass index (BMI)	0.6	2.7	8.8	1.6	3.0	1.5	1.6	-0.5	2.3	-1.6	-0.1	1.1	0.9	1.6
Waist circumference	0.6	2.1	5.8	1.1	1.3	1.2	1.1	-1.7	2.4	-2.3	-1.0	0.7	1.0	1.1
Arm fat mass (right)	0.6	2.6	7.1	1.6	2.3	1.4	1.6	-0.8	2.7	-1.7	-0.5	1.3	1.1	1.6
Tense / ‘highly strung’	0.6	0.9	2.6	1.3	0.8	1.2	1.3	-0.3	-0.1	-1.6	0.3	0.5	0.2	1.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	3.4	0.6	-0.1	0.7	0.7	-0.3	-0.2	-1.2	-1.8	0.9	0.8	0.7
Blood clot in the leg (DVT)	0.6	0.8	3.6	0.6	1.9	0.3	0.6	-0.3	0.7	-1.1	-0.8	0.7	1.0	0.6
Pulse rate, automated reading	0.6	1.9	3.0	1.7	1.4	1.2	1.6	0.8	-1.7	-1.5	0.0	1.1	1.6	1.6
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	3.3	0.2	-0.7	0.3	0.2	1.8	0.9	1.1	1.2	0.5	-0.3	0.2
Long-standing illness, disability or infirmity	0.6	0.9	2.8	-0.7	1.2	-0.9	-0.7	-1.1	1.1	0.5	-1.7	-1.1	-0.5	-0.7
Mother’s age at death	0.6	0.7	2.4	-0.6	-1.5	-0.4	-0.5	-0.5	0.9	0.7	0.3	-0.6	-1.6	-0.5
Medication: Atorvastatin	0.6	0.7	1.3	-1.1	-0.4	-0.8	-1.1	-0.6	1.0	0.6	-1.0	-0.7	-0.3	-1.1
Pain experienced in last month	0.6	1.1	2.8	1.0	1.6	1.7	1.0	0.3	-0.8	-1.5	0.0	0.8	0.2	1.0
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	3.4	0.6	1.8	0.3	0.5	-0.4	0.6	-1.1	-0.9	0.6	1.1	0.5
Schizophrenia vs Biploar Disorder	0.5	0.7	3.0	-0.2	1.7	-0.1	-0.3	0.2	1.7	0.5	0.2	-0.5	-0.9	-0.3
Coronary Artery Disease (CAD)	0.5	0.6	3.1	-0.6	0.5	-1.0	-0.7	-0.3	0.0	1.8	-0.6	-0.5	-0.2	-0.7
Ulcerative Colitis	0.5	0.7	2.8	0.8	-0.2	0.5	0.7	1.2	-1.7	0.0	0.9	0.7	-0.4	0.7
Townsend deprivation index at recruitment	0.5	0.6	1.9	-0.8	-0.0	-0.0	-0.9	-1.4	0.8	-0.8	-0.4	-0.8	0.9	-0.9
Average weekly fortified wine intake	0.5	0.6	3.8	0.3	-0.7	0.4	0.3	-0.0	-2.0	-0.9	0.3	0.5	0.6	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.5	0.8	0.4	0.9	0.6	-1.0	0.0	-1.6	-0.5	-0.5	1.2	0.6
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.4	-1.2	-0.6	-0.4	-1.2	-0.2	0.5	0.7	0.6	-0.3	-0.3	-1.2
Supplements: Glucosamine	0.5	0.7	2.9	0.4	-1.1	0.5	0.5	1.7	-0.9	0.6	1.1	0.1	0.2	0.5
Nervous feelings	0.5	1.0	4.6	0.7	-0.2	1.3	0.7	-0.6	-0.7	-2.1	-0.3	0.4	1.5	0.7
Hair/balding pattern: Pattern 2	0.5	0.6	2.7	0.8	0.5	0.8	0.7	-0.5	0.4	-0.8	-0.5	-0.4	1.6	0.7
Mouth/teeth dental problems	0.5	0.7	1.4	-0.9	0.3	-1.2	-0.9	-0.2	1.1	1.0	-0.4	-0.8	-0.9	-0.9
Noisy workplace	0.5	0.7	2.1	0.6	1.2	0.3	0.8	-0.9	1.5	-0.4	-0.3	0.9	-0.2	0.8
Pulse wave reflection index	0.5	0.6	1.4	0.3	0.5	0.7	0.3	1.1	1.0	0.6	1.2	-0.4	1.0	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	1.4	0.7	-0.7	0.0	0.7	-1.0	-1.2	-0.7	-0.6	-0.2	0.9	0.7
Had major operations	0.5	0.5	2.2	-0.4	-0.2	-0.4	-0.3	1.3	0.6	1.5	0.6	-0.1	-0.9	-0.3
Commuting to job workplace: Car/motor vehicle	0.5	0.6	3.2	-0.9	-0.3	-0.4	-0.9	-0.3	0.1	0.0	-1.8	-0.6	-0.6	-0.9
Loneliness, isolation	0.5	0.7	3.2	0.6	0.6	0.7	0.4	-0.7	1.1	-1.0	0.0	-0.1	1.8	0.4
Medication for cholesterol	0.5	0.7	1.5	1.0	0.2	0.3	1.0	1.2	1.2	0.7	0.7	1.0	-0.2	1.0
Back pain experienced in last month	0.5	0.7	2.7	0.6	0.4	0.1	0.6	0.8	1.4	0.9	1.6	0.4	0.4	0.6
Osteoarthritis (self-reported)	0.5	0.6	1.9	0.6	-0.4	0.3	0.6	-1.4	0.6	-1.2	-0.8	0.5	1.0	0.6
Guilty feelings	0.5	0.8	3.1	0.7	0.8	0.9	0.7	-0.7	1.8	-1.2	-0.7	0.2	0.2	0.7
Financial situation satisfaction	0.5	0.6	3.0	-0.4	-0.6	0.3	-0.4	-1.0	0.8	-0.4	1.1	0.2	1.7	-0.4
Depression (Nagel 2018)	0.4	0.5	2.4	-0.1	0.1	0.1	-0.3	-1.0	1.5	-1.0	-0.8	-0.8	0.1	-0.3
Alzheimer’s Disease (in father)	0.4	0.5	2.0	-0.3	-0.1	-0.7	-0.2	-1.1	1.4	-0.6	-0.6	0.3	0.7	-0.2
Irritable Bowel Disease (IBD)	0.4	1.0	2.4	1.1	1.5	1.1	1.2	0.6	-0.7	-0.3	0.7	1.4	0.4	1.2
Reaction Time	0.4	0.8	4.4	-0.1	-0.8	-0.3	-0.1	0.5	0.0	1.2	2.1	-1.1	0.1	-0.1
BMI	0.4	2.1	9.1	0.6	2.4	0.6	0.6	-1.1	3.0	-1.2	-1.7	0.3	0.7	0.6
Systolic Blood Pressure	0.4	1.8	10.6	-0.4	1.9	-0.5	-0.7	-0.2	-3.3	0.3	-1.0	-1.1	1.2	-0.7
Hypothyroidism (self reported)	0.4	0.8	2.7	-1.0	0.3	-0.8	-1.0	-1.0	0.3	-0.4	-1.6	-0.8	-0.8	-1.0
Ever had hysterectomy (womb removed)	0.4	0.5	1.2	-0.8	-0.7	-0.4	-0.7	0.4	-0.9	1.1	0.3	-0.7	0.2	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	3.1	0.5	1.3	0.3	0.5	1.1	1.8	1.1	0.6	-0.1	-0.4	0.5
Pulse rate	0.4	0.6	2.4	0.3	0.1	0.5	0.3	-1.5	-1.1	-1.5	0.2	0.5	0.3	0.3
Exposure to tobacco smoke at home	0.4	0.4	3.6	0.3	1.9	0.3	0.2	0.5	0.7	0.1	-0.3	0.3	0.1	0.2
Medication: Ventolin 100micrograms inhaler	0.4	0.5	3.6	-0.6	-0.4	-0.7	-0.5	0.1	-1.9	0.4	-0.2	-0.2	-0.8	-0.5
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.0	-0.5	-1.0	-0.4	-0.5	-0.5	-1.0	0.6	0.6	-0.8	0.7	-0.5
Mean time to correctly identify matches	0.4	0.9	3.1	-0.3	-1.1	-0.7	-0.4	0.6	0.1	1.3	1.8	-1.4	-0.4	-0.4
Age at last live birth	0.4	0.7	1.2	0.8	-0.3	0.9	0.7	1.1	-1.0	-0.7	-0.1	0.8	1.1	0.7
Leg pain on walking	0.4	0.5	1.4	0.6	-1.2	0.3	0.7	1.1	-0.4	0.9	-0.1	0.6	0.2	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	2.2	0.1	0.7	0.8	0.1	-0.4	0.1	-1.1	1.5	0.4	0.1	0.1
Eye problems/disorders: Cataract	0.4	0.5	2.9	0.2	-1.3	-0.3	0.3	0.6	-1.7	0.3	0.2	0.1	-0.3	0.3
Tinnitus: Yes, now most or all of the time	0.4	0.4	2.2	-0.4	-1.5	-0.4	-0.3	0.8	-0.7	0.4	0.4	0.0	-0.8	-0.3
Eye problems/disorders: Glaucoma	0.4	0.4	1.7	0.6	-0.9	0.3	0.6	0.3	-1.3	-0.2	0.4	0.8	-0.3	0.6
Irritability	0.4	0.6	2.6	0.6	0.7	0.3	0.7	-1.4	0.4	-1.6	0.3	0.3	-0.1	0.7
Commuting to job workplace: Cycle	0.4	0.5	2.1	-0.1	0.9	0.4	0.1	0.9	1.4	0.2	0.5	1.3	0.1	0.1
Blood White Count	0.3	2.1	6.9	1.5	-1.1	1.9	1.5	-0.2	-0.8	-2.6	0.5	1.4	1.2	1.5
Hair Pigment	0.3	7.6	13.5	-3.6	-0.2	-2.9	-3.6	-3.3	0.1	1.2	-3.7	-2.6	-1.9	-3.6
Medication: Co-codamol	0.3	0.4	1.2	-0.4	0.3	-0.9	-0.4	-0.2	1.1	0.3	0.6	-0.6	-0.6	-0.4
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.8	0.4	-0.3	-0.1	0.5	-0.4	1.3	0.2	0.9	0.4	0.4	0.5
Number of incorrect matches in round	0.3	0.4	1.9	0.5	0.7	0.5	0.5	1.1	-0.0	-0.5	1.4	-0.1	0.2	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	2.7	-0.2	0.5	0.4	-0.4	-0.7	1.6	-0.8	0.0	-0.4	0.3	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.7	0.9	1.3	0.6	0.8	0.8	1.3	0.1	-0.3	0.4	-0.1	0.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.3	-0.2	-0.7	-0.1	-0.2	-1.0	1.1	-0.2	-0.8	0.1	0.4	-0.2
Pain all over the body in last month	0.3	0.3	1.5	0.0	-0.0	0.0	-0.1	0.6	-1.1	0.2	-0.2	-0.1	-1.2	-0.1
Weight	0.3	1.4	10.0	0.1	1.5	0.2	0.2	-1.3	3.2	-0.2	-1.0	0.1	-0.4	0.2
Happiness	0.3	0.3	1.2	0.5	0.5	0.1	0.4	-1.1	0.5	-0.9	0.6	-0.1	0.5	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.6	0.4	-1.3	0.2	0.6	0.3	0.4	-0.8	0.2	0.7	0.3	0.6
Hair/balding pattern: Pattern 4	0.3	0.6	1.5	0.8	1.2	0.9	0.7	1.1	0.5	-0.3	0.4	1.2	-0.2	0.7
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.4	-0.5	-0.7	-0.3	-0.5	0.3	0.7	1.2	0.3	-0.7	-0.9	-0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.4	-0.9	0.2	-0.8	-0.9	-0.6	0.0	-0.1	-1.6	-0.8	-0.6	-0.9
Eye problems/disorders: None of the above	0.3	0.4	1.7	-0.8	0.1	0.2	-0.8	-0.1	1.3	-0.1	-0.5	-0.5	0.2	-0.8
Emphysema/chronic bronchitis	0.3	0.3	1.7	-0.3	0.3	-0.4	-0.4	-0.8	0.1	0.3	-0.7	-1.3	-0.2	-0.4
Family relationship satisfaction	0.3	0.3	1.3	0.5	0.1	0.5	0.5	-0.2	0.8	-1.2	0.6	0.4	0.3	0.5
Illnesses of siblings: Diabetes	0.3	0.4	2.1	0.4	1.4	0.5	0.3	0.3	0.9	-0.2	0.7	-0.0	0.4	0.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.9	0.6	1.4	0.9	0.4	0.7	-1.0	0.3	-0.5	-0.3	0.4	0.4
Pain type(s) experienced in last month: Hip pain	0.3	0.3	1.4	0.5	-0.2	0.0	0.5	1.2	-0.8	0.4	-0.1	0.6	0.1	0.5
Medication: Lisinopril	0.3	0.4	2.2	0.0	-1.3	0.3	0.0	-0.1	-1.5	-0.5	-0.5	-0.1	0.2	0.0
Ever depressed for a whole week	0.3	0.3	0.8	0.5	-0.7	0.4	0.5	-0.6	-0.2	-0.9	-0.7	0.3	0.2	0.5
Unable to work because of sickness or disability	0.3	0.5	1.7	0.6	1.3	0.5	0.5	-0.0	0.1	-0.2	-1.2	-0.4	-0.6	0.5
Basal cell carcinoma (self-reported)	0.3	0.3	1.5	0.4	0.2	0.7	0.5	1.2	0.2	0.3	-0.0	0.4	0.6	0.5
Heart disease (siblings)	0.3	0.4	0.9	-0.9	0.3	-0.7	-0.9	-0.5	0.5	0.2	-0.6	-0.4	0.1	-0.9
Ulcerative Colitis (UC)	0.2	0.4	1.4	0.6	0.0	0.3	0.5	0.9	-1.2	0.5	-0.3	0.6	-0.7	0.5
Age at First Birth	0.2	0.3	0.8	0.7	-0.7	0.4	0.7	0.9	-0.3	0.1	0.1	0.4	-0.5	0.7
HDL Cholesterol	0.2	0.3	0.9	-0.4	-0.2	-0.7	-0.4	-0.0	0.7	0.4	0.9	-0.5	-0.8	-0.4
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.9	-0.1	-0.3	-0.1	-0.3	-0.6	-0.4	-0.5	-0.9	-0.6	-0.2	-0.3
Blood Red Count	0.2	1.5	3.8	-1.2	1.0	-1.2	-1.2	-1.2	1.2	0.9	-0.2	-1.9	-1.3	-1.2
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.9	0.7	-0.2	0.6	0.5	-0.2	0.9	-0.6	0.2	-0.1	0.9	0.5
Multivitamins +/- minerals	0.2	0.3	1.4	0.2	0.7	-0.2	0.2	0.5	-0.3	1.2	-0.6	0.4	0.2	0.2
Stomach or abdominal pain in last month	0.2	0.2	0.5	0.0	0.7	-0.2	0.1	-0.2	-0.3	0.6	0.6	-0.7	-0.5	0.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	0.5	0.5	0.1	0.5	0.3	-0.0	0.6	0.6	0.3	-0.4	0.5
Medication: Levothyroxine sodium	0.2	0.3	1.3	-0.5	-0.6	-0.3	-0.4	-0.2	-0.4	-0.4	-1.1	0.1	-0.4	-0.4
Chronic bronchitis/emphysema (father)	0.2	0.2	0.8	-0.5	0.9	-0.2	-0.5	0.2	0.2	0.1	-0.8	-0.1	-0.0	-0.5
Hearing difficulty/problems with background noise	0.2	0.4	2.0	-0.4	0.3	-0.1	-0.5	-0.4	1.4	0.4	0.2	-0.6	-0.9	-0.5
Hip circumference	0.2	0.9	4.1	0.9	1.5	0.7	0.8	-0.6	2.0	-0.3	-0.2	0.2	-0.3	0.8
Birth weight of first child	0.2	0.4	1.4	-0.4	-1.2	-0.7	-0.3	0.5	-0.8	0.7	0.9	-0.2	0.2	-0.3
Headache pain in last month	0.2	0.4	1.5	0.3	-0.6	0.1	0.3	1.2	0.9	0.4	0.8	0.7	0.5	0.3
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.1	-0.0	1.1	-0.1	0.0	-0.1	0.6	-0.8	-0.8	0.4	0.1	0.0
Health satisfaction	0.2	0.3	2.0	0.3	1.4	0.3	0.3	-0.5	0.5	-0.2	0.7	0.1	0.3	0.3
Medication for pain relief, constipation, heartburn	0.2	0.4	3.4	-0.0	-0.1	0.1	-0.1	0.2	-1.8	0.1	0.3	-0.4	-0.6	-0.1
Alcohol intake frequency.	0.2	0.4	2.5	0.4	1.6	0.5	0.3	0.1	0.6	0.2	0.0	0.1	1.0	0.3
Suffer from ‘nerves’	0.2	0.3	0.9	0.2	-0.3	0.3	0.4	0.2	0.6	-0.7	0.9	1.0	0.4	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.8	-0.1	-0.9	-0.3	-0.1	0.6	-0.5	0.8	-0.2	-0.6	-0.4	-0.1
High cholesterol (Self-reported)	0.2	0.4	1.8	-0.5	-1.4	0.1	-0.5	0.5	-1.0	0.1	0.3	-0.1	-0.1	-0.5
Cholesterol lowering medication	0.2	0.4	0.7	-0.9	-0.1	-0.1	-0.8	-0.3	-0.0	-0.0	-0.8	-0.8	-0.7	-0.8
Body Mass Index (BMI) (2010)	0.1	0.2	0.5	0.1	0.5	-0.1	0.0	0.6	0.6	0.7	0.0	-0.6	-0.4	0.0
Lupus	0.1	0.2	0.4	0.1	-0.2	0.6	0.1	0.4	0.6	-0.1	0.6	-0.2	-0.5	0.1
Heel T-Score	0.1	0.6	1.3	-0.7	0.7	-1.0	-0.8	-0.4	-0.7	0.5	-1.1	-1.1	0.2	-0.8
Tanning	0.1	1.4	5.2	-1.2	-1.1	-1.0	-1.2	-2.3	-0.5	-0.2	-0.5	-1.0	1.5	-1.2
Diabetes (mother)	0.1	0.1	0.5	0.3	0.6	0.3	0.2	-0.1	0.3	-0.5	-0.3	0.1	0.7	0.2
Medication: Simvastatin	0.1	0.2	0.6	0.1	0.1	0.5	0.0	0.7	-0.8	-0.1	0.7	-0.1	0.1	0.0
Medication: Cholesterol lowering	0.1	0.2	1.1	0.2	0.1	0.3	0.1	0.5	-0.2	0.2	1.0	0.4	0.4	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	0.2	-0.3	0.1	0.3	-0.5	-0.6	-0.3	0.5	0.2	0.7	0.3
Medication: Ibuprofen	0.1	0.2	0.8	0.2	-0.9	-0.1	0.4	0.6	0.3	-0.2	0.3	0.5	0.1	0.4
Comparative height size at age 10	0.1	0.7	1.4	-1.1	-1.0	-0.4	-1.0	0.4	1.2	1.0	-0.7	-0.4	-0.7	-1.0
Friendships satisfaction	0.1	0.2	0.9	0.0	0.2	0.1	-0.0	0.7	0.9	-0.0	0.3	-0.4	-0.4	-0.0

Hub : Genes

MDM4

Models

Trait associations