Best TWAS P=1.35e-10 · Best GWAS P=3.86e-13 conditioned to 5.49e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | IKBKE | 0.35 | 0.31 | lasso | 7 | 0.29 | 1.2e-19 | 6.2 | -6.1 | 9.3e-10 | 0.00 | 0.60 | 0.40 | FALSE |
| 2 | GTEx | Esophagus Muscularis | IKBKE | 0.20 | 0.07 | lasso | 3 | 0.08 | 1.8e-05 | 4.5 | -5.2 | 2.4e-07 | -0.03 | 0.44 | 0.11 | FALSE |
| 3 | GTEx | Heart Left Ventricle | DYRK3 | 0.27 | 0.24 | lasso | 2 | 0.21 | 2.2e-11 | 5.1 | -5.3 | 1.4e-07 | 0.08 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | IKBKE | 0.48 | 0.32 | lasso | 9 | 0.30 | 5.3e-17 | 6.2 | -6.4 | 1.3e-10 | -0.02 | 0.61 | 0.39 | TRUE |
| 5 | GTEx | Skin Sun Exposed Lower leg | IKBKE | 0.38 | 0.39 | enet | 8 | 0.39 | 1.2e-34 | 6.0 | -6.2 | 5.4e-10 | 0.01 | 0.62 | 0.38 | FALSE |
| 6 | GTEx | Thyroid | DYRK3 | 0.11 | 0.13 | lasso | 2 | 0.12 | 1.4e-09 | -6.1 | 6.2 | 6.7e-10 | -0.08 | 0.65 | 0.34 | TRUE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | RASSF5 | 0.15 | 0.07 | enet | 30 | 0.09 | 2.1e-11 | -4.4 | -5.3 | 1.2e-07 | -0.01 | 1.00 | 0.00 | FALSE |