Hub : Genes

DYRK3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.0958 0.0354 3.1e-03 -0.003 NA -0.003 NA -0.003 8.0e-01 NA 6.0e-01 NA 7.3e-01
2 GTEx Heart Left Ventricle 0.2714 0.0556 2.4e-07 0.238 NA 0.171 NA 0.209 6.5e-13 NA 2.0e-09 NA 2.2e-11
3 GTEx Thyroid 0.1120 0.0360 2.4e-04 0.129 NA 0.093 NA 0.122 4.7e-10 NA 1.4e-07 NA 1.4e-09
4 METSIM Adipose 0.0444 0.0188 3.4e-03 0.037 0.018 0.020 0.025 0.027 2.5e-06 0.00079 4.5e-04 9.8e-05 5.3e-05
5 ROSMAP Brain Pre-frontal Cortex 0.0310 0.0159 8.9e-03 0.000 0.007 0.004 0.007 -0.002 3.7e-01 0.03700 8.8e-02 3.9e-02 7.2e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.2 0.3 0.6 0.0 -0.6 -0.8 -0.1 0.5
Bipolar Disorder or Schizophrenia 0.1 0.2 1.0 0.0 -1.0 0.2 -0.1 0.1
Depressed Affect (Nagel 2018) 0.1 0.3 1.1 0.0 1.1 0.4 0.2 -0.3
Depression (Nagel 2018) 0.6 0.9 1.6 0.0 -1.2 1.3 1.1 0.7
Intelligence (Savage-Jansen 2018) 0.0 0.1 0.3 0.0 0.4 0.2 -0.5 -0.0
Neuroticism (Nagel 2018) 0.2 0.6 1.9 0.0 1.4 0.5 0.2 0.8
Schizophrenia (2018) 0.1 0.3 0.7 0.0 -0.8 0.9 -0.0 -0.3
Schizophrenia vs Biploar Disorder 0.2 0.3 0.7 0.0 -0.2 0.8 0.9 -0.2
Worry (Nagel 2018) 0.3 0.6 1.6 0.0 1.3 0.4 0.1 1.2
Alzheimer’s Disease (in mother) 0.0 0.0 0.1 0.0 -0.1 0.1 0.3 -0.4
Alzheimer’s Disease (in father) 1.0 1.1 2.0 0.0 -1.4 1.3 1.4 -0.4
Alzheimer’s Disease (including proxy) 0.4 0.5 1.5 0.0 -1.2 -0.2 0.6 -0.9
Crohns Disease (2017) 1.0 2.2 7.8 0.0 0.9 -2.8 0.5 -1.4
Irritable Bowel Disease (IBD) 1.3 3.1 7.6 0.0 0.5 -2.8 0.8 -2.7
Ulcerative Colitis (UC) 1.2 2.2 9.1 0.0 -0.3 -1.0 0.9 -3.0
Major Depression (MDD) 0.1 0.2 0.3 0.0 0.5 -0.5 -0.4 -0.4
Reaction Time 2.0 3.8 7.7 0.0 2.8 -2.0 -2.4 -1.3
Verbal and Numeric Reasoning (VNR) 0.3 0.7 2.7 0.0 1.6 -0.2 0.5 0.7
Breast Cancer 0.6 1.3 4.7 0.0 -1.4 -0.0 -2.2 -0.2
Ovarian Cancer 0.4 0.5 1.2 0.0 1.1 0.4 1.0 0.3
Prostate Cancer 0.3 0.5 1.2 0.0 -1.0 1.1 0.4 0.1
Age at First Birth 0.4 0.6 1.2 0.0 1.1 -0.7 -1.1 0.5
Bipolar Disorder (2011) 1.0 0.9 1.8 0.0 0.3 -1.4 -1.2 1.1
Body Mass Index (BMI) (2010) 0.7 1.0 3.1 0.0 -0.5 1.8 0.7 1.0
Coronary Artery Disease (CAD) 0.3 0.4 1.6 0.0 -0.6 0.4 -0.2 1.2
Crohns Disease (2012) 1.7 2.8 10.5 0.0 0.9 -3.2 -1.0 -1.3
Mean Putamen Volume 0.9 1.0 4.0 0.0 -0.9 -0.3 -0.6 -2.0
Fasting Glucose 0.3 0.4 1.8 0.0 0.1 1.3 0.1 -0.1
HbA1C 1.3 1.5 6.3 0.0 0.0 1.0 2.5 -0.1
HDL Cholesterol 0.6 1.0 3.5 0.0 -1.2 -0.2 -0.3 -1.9
LDL Cholesterol 0.9 1.4 5.6 0.0 -1.2 0.4 0.2 2.4
Lupus 1.8 2.8 9.9 0.0 1.3 -3.1 -0.4 -1.4
Neuroticism (2016) 0.7 1.0 2.3 0.0 0.7 0.7 1.3 1.5
Primary Biliary Cirrhosis 3.3 4.7 13.5 0.0 -0.1 -2.2 -2.3 -3.7
Rheumatoid Arthritis 1.8 2.4 8.2 0.0 0.3 1.2 -1.6 -2.9
Schizophrenia (2014) 0.1 0.3 0.7 0.0 -0.8 0.4 -0.4 -0.8
Triglycerides 0.8 1.2 3.1 0.0 -1.8 1.2 1.2 -0.5
Type 2 Diabetes (T2D) (2012) 0.7 0.8 2.7 0.0 -1.6 0.7 0.9 -0.2
Ulcerative Colitis 3.2 4.6 15.3 0.0 2.1 -1.8 -0.4 -3.9
Blood Eosinophil Count 1.7 13.3 38.1 0.0 -5.3 6.2 0.5 0.7
Blood Platelet Count 0.1 1.2 3.1 0.0 -1.8 1.3 1.0 -0.4
Blood Red Count 0.3 3.2 8.0 0.0 -2.8 2.6 0.7 0.9
Blood White Count 0.3 2.4 8.3 0.0 -1.4 1.1 0.7 2.9
Heel T-Score 0.0 0.2 0.7 0.0 0.3 -0.4 -0.6 0.8
BMI 0.5 3.0 8.2 0.0 -2.9 -0.2 -1.2 2.3
Height 0.3 5.5 16.5 0.0 3.2 0.5 0.7 4.1
Waist Hip Ratio (WHR) 0.0 0.1 0.3 0.0 0.5 -0.3 -0.0 -0.5
Systolic Blood Pressure 0.3 1.6 3.7 0.0 1.0 -0.9 -1.9 1.5
Smoking Status 0.2 0.6 2.3 0.0 0.7 0.4 0.1 -1.5
Allergy or Eczema 1.0 2.7 7.0 0.0 1.0 -2.3 -0.6 -2.6
Cardiovascular Disease 0.3 0.9 2.0 0.0 0.9 -1.3 -1.4 -0.2
Hypothyroidism (self reported) 1.1 2.4 7.6 0.0 -1.8 -1.0 -0.4 -2.8
Respiratory disease 1.2 2.6 8.6 0.0 -1.4 -1.5 -2.9 -0.5
Type 2 Diabetes (T2D) (2018) 1.1 2.0 4.4 0.0 -1.8 -0.4 -2.1 -1.5
Lung FEV1/FVC ratio 0.2 0.9 2.0 0.0 -0.5 1.4 0.7 -1.4
Lung FVC 0.3 1.4 4.1 0.0 -1.2 0.6 1.1 -2.0
Neuroticism 0.3 0.8 3.5 0.0 1.9 0.5 -0.6 0.1
Chronotype (morning person) 0.1 0.2 0.5 0.0 0.7 -0.5 0.6 0.1
Hair Pigment 0.0 0.9 2.0 0.0 0.0 -1.1 -1.4 1.1
Tanning 0.1 0.9 1.9 0.0 0.8 0.5 1.4 1.4
Hand grip strength (left) 0.8 2.0 8.2 0.0 -0.6 0.1 1.2 2.9
Number of treatments/medications taken 2.8 5.0 14.1 0.0 0.7 -1.9 -3.8 -2.6
Average weekly spirits intake 0.3 0.4 1.4 0.0 -0.0 0.2 -0.8 1.2
Sensitivity / hurt feelings 0.7 1.1 3.5 0.0 0.6 1.9 1.3 0.2
Frequency of depressed mood in last 2 weeks 0.4 0.6 1.6 0.0 1.3 -0.6 -0.1 1.0
Hearing difficulty/problems: Yes 0.9 1.4 3.3 0.0 0.8 -1.8 -1.3 -1.2
Relative age of first facial hair 0.3 0.5 1.1 0.0 -0.8 1.0 -0.2 1.0
Other serious medical condition/disability diagnosed by doctor 3.0 3.9 8.7 0.0 -1.4 -0.7 -3.0 -2.9
Ever used hormone-replacement therapy (HRT) 0.7 0.9 4.2 0.0 -0.3 0.4 -0.3 -2.0
Ever had hysterectomy (womb removed) 0.3 0.4 1.0 0.0 0.3 0.7 1.0 -0.5
Systolic blood pressure, automated reading 0.2 0.5 1.5 0.0 0.2 1.0 0.2 1.2
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.6 0.0 0.8 -0.8 -0.6 -0.0
Angina 1.4 1.8 4.8 0.0 -0.2 -1.5 -1.4 -2.2
Medication for hormone replacement therapy 0.2 0.2 0.5 0.0 0.7 -0.3 -0.3 -0.6
Vitamin and mineral supplements 0.5 0.6 1.7 0.0 0.6 -1.1 -0.1 1.3
Supplements: Zinc 1.0 1.1 3.1 0.0 -0.9 -1.8 -0.7 -1.0
Medication: Co-codamol 0.3 0.4 0.9 0.0 -0.7 -0.5 -0.4 -1.0
Medication: Metformin 1.0 1.4 3.3 0.0 -0.7 -0.2 -1.8 -1.7
Diabetes (father) 0.3 0.4 0.7 0.0 -0.7 0.8 -0.4 0.7
Diabetes (mother) 0.2 0.2 0.6 0.0 0.0 0.7 -0.3 0.8
Severe depression (siblings) 0.7 0.7 1.3 0.0 1.0 0.8 -0.9 1.1
Pack years adult smoking proportion 0.5 0.8 1.7 0.0 -0.4 1.3 0.8 -1.3
Impedance of leg (right) 0.2 1.1 5.2 0.0 2.3 0.1 0.3 -0.2
Leg fat-free mass (left) 0.3 1.8 5.9 0.0 -1.6 -0.0 0.6 2.4
Trunk fat percentage 0.3 1.1 3.5 0.0 -0.6 -0.5 -1.9 1.3
Hand grip strength (right) 0.8 2.1 7.1 0.0 -0.5 0.8 1.5 2.7
Townsend deprivation index at recruitment 0.9 1.3 2.8 0.0 1.7 -1.5 -1.2 -0.2
Current tobacco smoking 0.7 1.2 5.2 0.0 0.8 -0.1 -0.5 -2.3
Average weekly fortified wine intake 1.4 1.6 4.3 0.0 1.6 0.4 0.9 -2.1
Maternal smoking around birth 0.4 0.6 1.3 0.0 1.0 -0.5 -0.8 -1.1
Fed-up feelings 0.6 1.0 4.3 0.0 2.1 0.1 -0.2 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 3.9 0.0 0.3 0.7 2.0 1.0
Relative age voice broke 0.5 0.8 2.1 0.0 -1.1 0.6 -0.4 1.4
Taking other prescription medications 4.3 6.6 17.5 0.0 -0.4 -2.2 -3.2 -4.2
Age when periods started (menarche) 0.2 0.5 1.8 0.0 -0.9 -0.1 0.0 -1.3
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 1.4 0.0 -0.2 1.2 0.0 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.4 6.0 0.0 1.0 1.1 2.5 1.9
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.5 0.0 0.2 -0.7 -0.1 -0.5
Qualifications: CSEs or equivalent 0.5 0.6 2.5 0.0 1.6 0.6 0.4 0.3
Serious illness, injury or assault to yourself 0.4 0.4 1.5 0.0 -0.2 0.5 -0.6 -1.2
High blood pressure 0.1 0.3 1.0 0.0 -0.1 0.1 -0.5 -1.0
Hayfever, allergic rhinitis or eczema 1.2 2.6 5.4 0.0 1.2 -2.3 -0.9 -2.3
Multivitamins +/- minerals 0.1 0.2 0.7 0.0 -0.8 0.1 0.1 -0.3
Stomach or abdominal pain in last month 0.3 0.3 0.8 0.0 0.5 -0.5 -0.9 -0.6
Supplements: Glucosamine 0.6 0.8 3.7 0.0 -1.9 0.1 0.6 -0.4
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 1.6 0.0 1.1 -1.0 -0.3 -1.3
Medication: Atenolol 0.4 0.5 2.5 0.0 0.3 0.3 -0.0 -1.6
Medication: Levothyroxine sodium 2.6 4.4 9.5 0.0 -0.9 -1.7 -3.0 -3.1
Sitting height 0.3 2.5 6.1 0.0 1.6 -0.4 1.9 2.5
Chronic bronchitis/emphysema (father) 0.2 0.3 1.0 0.0 0.2 0.6 -1.0 -0.1
High blood pressure (mother) 0.8 1.2 3.5 0.0 0.3 -1.0 -1.1 1.9
Body mass index (BMI) 0.5 2.2 8.1 0.0 -2.9 0.4 -0.5 1.6
Impedance of leg (left) 0.3 1.5 6.4 0.0 2.5 -0.2 -1.0 -0.6
Leg predicted mass (left) 0.3 1.8 5.8 0.0 -1.7 0.0 0.7 2.4
Trunk fat mass 0.3 1.4 4.7 0.0 -0.9 -0.3 -1.2 2.2
Waist circumference 0.3 1.1 3.2 0.0 -1.8 0.4 -0.3 1.5
Number of incorrect matches in round 0.3 0.5 1.8 0.0 -0.4 -0.0 -0.5 -1.4
Past tobacco smoking 0.1 0.3 0.5 0.0 -0.7 0.4 0.5 -0.6
Alcohol usually taken with meals 0.2 0.4 0.9 0.0 0.3 -0.4 -0.9 -0.9
Nervous feelings 0.3 0.5 1.6 0.0 0.8 0.4 0.2 1.3
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 1.0 0.0 0.6 -1.0 -0.7 0.5
Hearing difficulty/problems with background noise 0.5 0.8 2.1 0.0 1.4 -1.1 -1.0 -0.1
Hair/balding pattern: Pattern 2 0.3 0.4 0.8 0.0 -0.4 -0.7 0.9 -0.7
Had menopause 1.9 2.4 4.2 0.0 -1.6 1.8 1.4 -2.0
Had other major operations 2.3 2.8 7.4 0.0 0.1 -1.6 -2.7 -1.9
Forced vital capacity (FVC) 0.1 0.5 2.3 0.0 -0.1 -0.2 1.5 0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 3.6 0.0 0.9 0.6 1.9 1.5
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 4.8 0.0 -0.5 0.3 -0.2 -2.2
Qualifications: None of the above 0.6 1.2 3.6 0.0 0.4 -0.6 -1.9 -1.4
Financial difficulties in last 2 years 0.1 0.2 0.5 0.0 0.3 0.4 -0.3 -0.7
Mouth/teeth dental problems 0.2 0.3 1.0 0.0 -0.0 -0.5 1.0 0.6
Heart attack 0.3 0.3 1.3 0.0 -0.1 0.1 -1.1 -0.7
Allergy 0.5 1.1 3.5 0.0 -0.2 1.9 0.7 1.2
Pain all over the body in last month 0.2 0.3 0.7 0.0 0.1 0.2 -0.8 0.7
Diabetes (self-reported) 1.7 2.7 6.6 0.0 -0.1 -0.9 -2.6 -2.4
Hayfever/allergic rhinitis (self-reported) 0.9 1.1 2.4 0.0 0.2 -1.5 -1.6 -1.0
Medication: Ramipril 0.0 0.0 0.2 0.0 -0.4 0.1 0.1 -0.0
Medication: Simvastatin 0.5 0.7 1.8 0.0 -0.4 0.0 -1.4 -1.1
Fluid intelligence score 0.3 0.7 1.8 0.0 1.3 -0.3 -0.3 1.3
Illnesses of siblings 0.2 0.2 0.6 0.0 0.0 0.8 0.4 0.7
Neuroticism score 0.5 1.1 4.6 0.0 2.1 0.4 0.1 0.7
Weight 0.5 2.3 7.7 0.0 -1.9 0.2 0.0 2.8
Impedance of arm (right) 0.9 4.4 18.1 0.0 4.2 -1.4 -1.2 -0.7
Arm fat percentage (right) 0.3 1.1 2.5 0.0 -0.8 -0.7 -1.6 1.4
Trunk fat-free mass 0.6 3.2 8.5 0.0 -1.7 1.1 1.9 2.9
Hip circumference 0.5 2.0 5.2 0.0 -2.1 0.6 -0.3 2.3
Time employed in main current job 0.1 0.1 0.2 0.0 -0.5 0.0 0.4 0.3
Alcohol intake versus 10 years previously 0.3 0.5 1.1 0.0 -1.1 0.5 0.5 -0.8
Father’s age at death 0.4 0.5 2.3 0.0 0.0 1.5 0.4 0.2
Worrier / anxious feelings 0.4 0.7 3.0 0.0 1.7 0.5 0.4 0.1
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.9 3.0 0.0 1.7 -0.3 -1.2 0.1
Falls in the last year 0.5 0.7 1.8 0.0 -0.7 0.9 1.3 -0.6
Hair/balding pattern: Pattern 3 0.5 0.7 1.6 0.0 -1.1 0.9 0.3 -1.3
Number of live births 0.4 0.6 2.4 0.0 1.5 0.3 -0.4 0.7
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 0.9 0.0 -0.4 -0.2 0.9 0.3
Pulse rate 0.8 1.4 3.9 0.0 0.4 -2.0 -1.6 0.3
Happiness 0.2 0.2 0.4 0.0 0.6 0.2 0.6 0.5
Noisy workplace 0.5 0.6 1.3 0.0 1.1 0.1 -0.8 0.9
Qualifications: A levels/AS levels or equivalent 0.4 1.0 4.3 0.0 -0.4 0.3 -0.4 2.1
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.5 0.0 0.5 -0.1 -0.7 0.2
Mouth/teeth dental problems: Dentures 0.4 0.6 1.9 0.0 -0.8 1.4 -0.7 0.1
Asthma 0.7 1.4 3.3 0.0 -1.6 -1.0 -1.8 -0.2
Medication: Ibuprofen (e.g. Nurofen) 2.6 3.3 7.5 0.0 1.6 -2.5 -2.7 -0.5
Medication: Cholesterol lowering 0.1 0.2 0.3 0.0 -0.6 0.4 -0.5 0.3
Depression (self-reported) 0.1 0.1 0.4 0.0 0.6 0.2 0.4 0.4
Medication: Lansoprazole 0.7 0.7 3.6 0.0 1.9 -0.3 -0.0 0.0
Prospective memory result 0.5 0.6 1.5 0.0 -0.3 -0.6 -1.1 1.2
Lung cancer (father) 0.8 1.0 2.9 0.0 -0.6 1.3 1.7 0.1
Illnesses of mother 0.0 0.0 0.1 0.0 -0.1 -0.3 -0.3 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.7 0.0 -0.0 -0.2 1.3 0.7
Pulse wave Arterial Stiffness index 0.4 0.5 1.5 0.0 0.5 1.2 -0.3 -0.7
Impedance of arm (left) 0.7 3.3 13.4 0.0 3.7 -0.9 -1.0 -1.0
Arm fat mass (right) 0.3 1.3 3.5 0.0 -1.6 -0.1 -0.8 1.9
Trunk predicted mass 0.5 3.1 8.2 0.0 -1.6 1.1 1.9 2.9
Standing height 0.3 2.7 7.6 0.0 2.0 -0.1 1.3 2.8
Length of working week for main job 0.2 0.2 0.5 0.0 -0.5 -0.2 -0.6 0.7
Exposure to tobacco smoke at home 1.4 1.6 3.1 0.0 1.2 -1.8 -1.2 -1.5
Breastfed as a baby 0.6 0.8 2.2 0.0 -1.1 -0.7 -1.5 0.2
Tense / ‘highly strung’ 0.2 0.3 0.4 0.0 0.6 -0.7 -0.6 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.2 0.6 0.0 0.8 -0.5 0.1 -0.6
Hair/balding pattern: Pattern 4 0.4 1.0 2.7 0.0 -1.6 0.9 0.2 1.1
Birth weight of first child 0.1 0.3 0.8 0.0 0.6 -0.9 -0.1 0.1
Peak expiratory flow (PEF) 0.4 0.8 1.8 0.0 -1.3 1.1 0.8 0.7
Pulse wave reflection index 0.6 0.8 2.6 0.0 1.6 0.4 1.0 -0.1
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.4 0.0 -0.7 0.1 0.6 0.4
Loud music exposure frequency 1.0 1.1 3.2 0.0 1.2 -1.8 -0.9 -0.1
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.8 0.0 -0.2 0.5 0.9 1.7
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 2.1 0.0 0.8 -1.4 -0.8 0.1
Blood clot in the leg (DVT) 0.7 0.9 3.3 0.0 0.9 -1.8 -0.5 0.3
Medication: Paracetamol 0.8 1.3 2.5 0.0 1.6 -1.5 -0.5 -1.3
Headache pain in last month 0.8 1.3 3.3 0.0 0.7 -1.1 -1.8 -1.3
Medication for cholesterol, blood pressure or diabetes 0.0 0.1 0.2 0.0 -0.0 -0.3 0.5 0.2
Glaucoma (self-reported) 2.1 2.4 7.2 0.0 -2.7 -0.8 -1.4 -1.5
Gout (self-reported) 0.5 0.6 2.0 0.0 0.6 -1.4 -0.7 -0.6
Hypothyroidism/myxoedema (self-reported) 1.4 2.8 8.0 0.0 -1.2 -1.5 -1.6 -2.8
Medication: Amlodipine 0.6 0.8 2.3 0.0 -1.4 0.3 0.0 -1.5
Medication: Ventolin 100micrograms inhaler 0.6 0.8 3.3 0.0 0.5 -0.4 -1.8 0.6
Birth weight 0.2 0.5 1.8 0.0 0.5 -0.4 0.5 1.4
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.2 0.0 0.1 0.4 -0.3 0.3
High blood pressure (siblings) 0.9 1.3 2.8 0.0 1.3 -1.7 -0.6 1.2
Forced vital capacity (FVC), Best measure 0.1 0.5 2.1 0.0 0.2 -0.1 1.4 0.7
Body fat percentage 0.3 1.1 2.5 0.0 -0.8 -0.4 -1.6 1.4
Leg fat percentage (right) 0.4 1.6 4.0 0.0 -1.8 0.7 -0.6 2.0
Arm fat-free mass (right) 0.6 3.0 6.6 0.0 -2.6 0.9 1.3 2.4
Exposure to tobacco smoke outside home 1.1 1.4 7.0 0.0 -0.3 -0.0 -0.2 -2.6
Comparative body size at age 10 0.1 0.4 0.7 0.0 -0.6 -0.6 -0.7 0.9
Number of full brothers 0.4 0.5 1.4 0.0 -1.2 0.2 -1.0 0.3
Worry too long after embarrassment 0.6 1.0 2.0 0.0 1.4 -0.9 -1.4 -0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.8 0.0 0.5 -0.9 -0.0 0.1
Wheeze or whistling in the chest in last year 1.3 2.2 9.1 0.0 -3.0 1.4 -0.1 0.1
Number of children fathered 0.7 0.8 2.1 0.0 -1.1 -0.3 -0.7 -1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.6 0.0 -0.1 -0.8 -1.3 -0.2
Age at first live birth 0.5 0.9 3.3 0.0 0.5 1.0 -0.5 1.8
Pulse wave peak to peak time 0.4 0.5 1.8 0.0 -0.3 -1.3 0.2 0.7
Health satisfaction 0.8 1.0 2.2 0.0 -1.5 -0.2 -1.2 -1.2
Shortness of breath walking on level ground 0.5 0.6 2.2 0.0 -1.5 0.1 -0.2 -0.8
Qualifications: College or University degree 0.1 0.2 0.6 0.0 -0.0 -0.3 0.4 0.8
Eye problems/disorders: None of the above 0.2 0.2 0.4 0.0 0.4 0.6 0.7 0.2
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.2 0.0 -0.7 -0.6 -0.3 1.1
Emphysema/chronic bronchitis 0.1 0.2 0.3 0.0 -0.4 0.5 -0.6 0.3
Medication for pain relief, constipation, heartburn 1.4 2.5 5.4 0.0 -1.7 1.6 2.3 1.2
Neck or shoulder pain in last month 0.2 0.3 0.7 0.0 -0.8 0.8 0.2 -0.5
Medication: Blood pressure 0.1 0.2 0.6 0.0 0.8 0.1 0.1 -0.6
Angina (self-reported) 1.4 1.9 4.0 0.0 -0.1 -1.5 -1.8 -2.0
Migraine (self-reported) 0.6 0.8 2.0 0.0 -0.9 -1.0 -1.4 0.1
Medication: Ibuprofen 2.9 3.5 8.4 0.0 1.7 -2.4 -2.9 0.1
Medication: Allopurinol 0.4 0.5 2.0 0.0 1.4 -0.6 -0.3 -0.5
Medication: Omeprazole 1.1 1.4 2.9 0.0 -1.2 1.7 -0.8 -1.3
Medication: Seretide 50 evohaler 1.4 1.6 6.4 0.0 0.8 -0.6 -0.8 2.5
Mean time to correctly identify matches 1.6 3.0 4.8 0.0 2.1 -1.3 -2.2 -2.0
Heart disease (mother) 0.6 0.8 1.6 0.0 -1.3 -0.4 -0.9 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 1.0 0.0 -0.7 0.5 -1.0 -0.6
Whole body fat mass 0.3 1.2 3.6 0.0 -1.2 -0.2 -1.0 1.9
Leg fat mass (right) 0.5 1.8 5.1 0.0 -1.9 0.5 -0.3 2.3
Arm predicted mass (right) 0.7 3.6 8.4 0.0 -2.9 1.2 1.4 2.5
Pulse rate, automated reading 0.6 2.0 6.1 0.0 0.2 -2.5 -2.0 -0.3
Alcohol intake frequency. 0.2 0.4 1.4 0.0 -1.2 0.2 0.1 -0.7
Comparative height size at age 10 0.6 3.2 7.3 0.0 2.5 0.5 1.3 2.7
Number of full sisters 0.4 0.5 1.9 0.0 -1.4 -0.6 -0.4 0.3
Suffer from ‘nerves’ 0.6 0.9 3.5 0.0 -0.5 0.8 0.3 1.9
Overall health rating 0.4 0.9 4.0 0.0 -0.1 -0.1 -2.0 -0.5
Chest pain or discomfort 0.6 0.8 2.4 0.0 1.0 -1.6 -0.9 -0.2
Had major operations 0.8 0.9 2.3 0.0 1.0 -0.6 -0.9 -1.5
Age at last live birth 1.2 1.8 6.5 0.0 1.0 1.2 -0.1 2.5
Family relationship satisfaction 0.4 0.4 1.5 0.0 0.8 -0.1 1.2 0.1
Leg pain on walking 1.3 1.7 4.2 0.0 -2.0 -1.2 -0.1 -1.6
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 1.9 0.0 -1.3 1.1 1.4 1.4
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.7 0.0 0.9 1.0 0.3 1.3
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.9 0.0 0.3 -1.0 -0.1 0.8
Medication: Aspirin 0.2 0.3 1.3 0.0 -0.1 -0.0 -1.1 -0.2
Supplements: Vitamin C 0.4 0.5 1.8 0.0 -0.2 0.5 0.4 -1.3
Knee pain experienced in last month 1.4 2.1 4.8 0.0 -1.1 2.0 2.2 0.8
Hypertension (Self-reported) 0.2 0.5 1.9 0.0 -0.3 0.0 -0.7 -1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.5 0.0 0.3 0.7 -0.1 -0.1
Illnesses of father: Heart disease 0.1 0.1 0.2 0.0 -0.1 -0.5 0.3 0.2
Illnesses of siblings: Diabetes 0.4 0.5 1.6 0.0 0.2 -0.0 -1.3 0.8
Smoking status: Previous 0.3 0.5 1.8 0.0 -0.3 0.7 -0.3 1.3
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 5.2 0.0 0.8 -0.9 -0.3 2.3
Whole body fat-free mass 0.5 2.6 7.2 0.0 -1.9 0.7 1.4 2.7
Leg fat-free mass (right) 0.3 1.6 5.0 0.0 -1.7 -0.3 0.2 2.2
Arm fat percentage (left) 0.3 1.1 2.0 0.0 -1.2 -0.3 -1.4 1.4
Average weekly red wine intake 0.4 0.6 1.9 0.0 -1.4 0.6 0.1 -0.7
Handedness (chirality/laterality): Left-handed 0.4 0.4 0.9 0.0 -0.7 -0.7 -0.6 -0.9
Mood swings 0.6 1.1 4.3 0.0 2.1 -0.0 -1.0 0.4
Loneliness, isolation 0.3 0.4 1.2 0.0 1.1 -0.5 -0.2 0.6
Long-standing illness, disability or infirmity 2.5 3.7 6.9 0.0 -2.6 -0.7 -2.4 -2.4
Ever had bowel cancer screening 1.3 1.5 5.6 0.0 2.4 -1.1 -0.6 -0.6
Diabetes diagnosed by doctor 1.3 2.2 4.9 0.0 -1.1 -0.2 -2.2 -2.2
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 2.1 0.0 1.5 -0.7 -0.3 0.8
Friendships satisfaction 1.0 1.2 4.1 0.0 -0.6 1.0 2.0 0.9
Qualifications: nursing, teaching 0.3 0.4 1.4 0.0 -1.2 -0.0 0.6 0.5
Commuting to job workplace: Walk 0.6 0.7 1.6 0.0 0.7 -0.7 -0.9 -1.3
Eye problems/disorders: Cataract 0.6 0.7 1.9 0.0 1.4 -0.1 -0.5 1.1
Mouth/teeth dental problems: Mouth ulcers 0.7 1.2 5.2 0.0 -0.7 2.3 0.4 -0.3
Medication for cholesterol 0.6 0.9 4.2 0.0 0.0 0.1 0.4 2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.7 3.3 0.0 -1.3 0.9 1.8 -1.5
Back pain experienced in last month 0.6 0.9 3.1 0.0 -0.4 -0.6 -1.8 -0.8
Mineral and other dietary supplements 1.1 1.5 2.7 0.0 1.5 -1.6 -1.2 1.1
Breast cancer (self-reported) 0.7 0.8 2.9 0.0 1.1 1.7 0.2 -0.2
Asthma (self-reported) 0.8 1.6 4.3 0.0 -1.2 -1.5 -2.1 -0.4
Osteoporosis (self-reported) 0.6 0.7 2.1 0.0 0.2 1.1 0.3 -1.4
Osteoarthritis (self-reported) 0.9 1.1 3.1 0.0 -1.2 1.0 0.1 -1.8
Medication: Aspirin 0.2 0.3 0.8 0.0 0.0 -0.0 -0.9 -0.7
Medication: Gliclazide 0.7 0.8 3.3 0.0 -0.1 -0.0 -1.8 -0.7
Illnesses of father: None of the above (group 1) 0.2 0.2 0.5 0.0 0.5 -0.4 0.5 -0.7
Smoking status: Current 0.9 1.5 4.6 0.0 1.5 -0.6 -0.6 -2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.0 0.1 0.3 0.0 -0.6 0.3 0.2 0.3
Whole body water mass 0.5 2.8 7.9 0.0 -2.0 0.6 1.3 2.8
Leg predicted mass (right) 0.3 1.6 5.1 0.0 -1.7 -0.2 0.2 2.3
Arm fat mass (left) 0.4 1.5 3.8 0.0 -1.7 0.1 -0.7 1.9
Number of self-reported non-cancer illnesses 0.8 1.5 3.9 0.0 -0.6 -0.7 -1.6 -2.0
Average weekly champagne plus white wine intake 1.3 1.8 7.7 0.0 2.8 -0.3 0.6 1.0
Miserableness 1.2 2.1 7.0 0.0 2.6 -1.7 -0.7 -0.5
Guilty feelings 0.3 0.4 1.3 0.0 0.9 -1.1 -0.1 0.2
Wears glasses or contact lenses 0.4 0.5 2.2 0.0 -0.4 1.5 0.2 -0.2
Ever taken oral contraceptive pill 0.7 0.8 1.3 0.0 1.1 -0.6 -1.0 -1.1
Hearing aid user 0.0 0.0 0.1 0.0 -0.3 0.0 0.1 -0.1
Mother’s age at death 0.2 0.2 0.7 0.0 0.1 0.5 0.5 -0.8
Financial situation satisfaction 0.3 0.4 1.5 0.0 -0.4 0.6 -0.3 -1.2
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.7 0.0 0.4 -0.4 -0.1 0.8
Commuting to job workplace: Public transport 2.2 2.6 4.5 0.0 -1.9 2.1 2.1 -0.5
Eye problems/disorders: Glaucoma 1.9 2.2 5.1 0.0 -2.3 -1.1 -1.9 -0.9
Medication: Blood pressure 0.3 0.6 2.4 0.0 -0.5 0.6 -0.1 -1.6
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.9 0.0 -0.5 -0.6 0.5 -1.4
Supplements: Fish oil (including cod liver oil) 0.3 0.4 2.0 0.0 -0.4 1.4 0.3 0.1
High cholesterol (Self-reported) 0.2 0.4 1.3 0.0 0.2 0.4 -1.2 -0.5
Medication: Bendroflumethiazide 0.1 0.2 0.5 0.0 0.5 -0.3 0.3 0.7
Medication: Paracetamol 0.6 0.9 1.7 0.0 1.1 -1.1 0.4 -1.3
Medication: Lisinopril 2.8 3.6 6.6 0.0 2.2 -2.3 -1.3 -2.6
Medication: Atorvastatin 0.6 0.8 1.8 0.0 -0.1 1.1 0.9 1.4
Illnesses of father: High blood pressure 0.5 0.6 2.3 0.0 -0.2 0.3 -0.8 1.5
Alcohol drinker status: Never 1.6 1.9 7.9 0.0 -2.8 -0.0 1.1 0.3
Ever smoked 0.3 0.5 1.2 0.0 1.1 -0.7 -0.7 0.3
Basal metabolic rate 0.5 2.8 8.4 0.0 -2.0 0.7 1.1 2.9
Leg fat percentage (left) 0.4 1.5 3.1 0.0 -1.7 0.5 -1.2 1.8
Arm fat-free mass (left) 0.6 2.9 7.1 0.0 -2.2 0.8 1.2 2.7
Number of operations (self-reported) 0.9 1.3 5.7 0.0 0.1 -0.3 -1.0 -2.4
Average weekly beer plus cider intake 1.0 1.4 4.6 0.0 -1.5 0.4 2.1 0.3
Irritability 0.4 0.7 1.5 0.0 1.0 0.7 0.7 1.2
Risk taking 1.1 1.6 3.0 0.0 0.3 -1.6 -1.7 -1.6
Ever had prostate specific antigen (PSA) test 1.5 1.7 5.5 0.0 1.0 -0.8 1.2 -2.4
Fractured/broken bones in last 5 years 0.3 0.3 0.8 0.0 0.9 -0.6 -0.6 0.5
Age started oral contraceptive pill 0.4 0.5 1.5 0.0 -1.2 0.6 0.7 -0.6
Diastolic blood pressure, automated reading 0.8 2.3 8.7 0.0 -0.2 1.3 1.1 3.0
Ever depressed for a whole week 0.6 0.8 1.6 0.0 1.2 -1.0 0.0 -1.2
Unable to work because of sickness or disability 0.7 0.9 2.3 0.0 0.6 0.8 -1.5 0.9
Commuting to job workplace: Cycle 0.9 1.1 3.8 0.0 0.5 -1.1 -0.5 1.9
Myopia 0.8 1.2 2.2 0.0 1.4 -1.5 0.3 -1.3
Vascular/heart problems diagnosed by doctor 0.2 0.6 1.6 0.0 0.7 -0.2 0.8 1.2
Cholesterol lowering medication 0.3 0.5 1.5 0.0 -0.3 -0.1 -0.9 -1.2
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 1.4 0.0 -0.6 1.2 -1.0 -1.0
Pain experienced in last month 0.1 0.1 0.4 0.0 -0.6 -0.1 0.2 0.5
Supplements: Calcium 0.6 0.7 2.7 0.0 0.5 -0.3 -0.7 -1.6
Basal cell carcinoma (self-reported) 0.5 0.5 1.7 0.0 0.2 -0.2 -1.0 1.3
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.1 0.0 -0.3 0.4 -1.0 -0.7
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.9 0.0 0.9 -1.7 -0.7 0.5
Heart disease (siblings) 1.2 1.4 3.2 0.0 -1.8 0.2 1.8 -0.8
Alcohol drinker status: Previous 1.7 1.9 4.4 0.0 0.7 -0.8 -2.0 -2.1
Pack years of smoking 0.6 0.9 2.4 0.0 -0.3 1.6 0.9 -1.1
Impedance of whole body 0.6 3.2 12.8 0.0 3.6 -0.8 -1.1 -1.1
Leg fat mass (left) 0.4 1.6 4.4 0.0 -1.7 0.3 -0.6 2.1
Arm predicted mass (left) 0.5 2.7 7.3 0.0 -2.0 0.8 1.3 2.7