Best TWAS P=1.48e-20 · Best GWAS P=1.42e-16 conditioned to 0.0098
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RABAC1 | 0.06 | 0.03 | lasso | 3 | 0.02 | 1.0e-03 | 5.2 | -5.2 | 1.7e-07 | -0.23 | 0.39 | 0.02 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | RABAC1 | 0.08 | 0.09 | lasso | 3 | 0.09 | 9.2e-08 | 5.2 | -5.3 | 1.3e-07 | -0.23 | 0.99 | 0.00 | TRUE |
| 3 | GTEx | Adipose Visceral Omentum | RABAC1 | 0.07 | 0.04 | enet | 19 | 0.04 | 4.5e-03 | -3.9 | -5.7 | 1.3e-08 | -0.47 | 0.12 | 0.24 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | RABAC1 | 0.25 | 0.23 | lasso | 2 | 0.22 | 1.8e-08 | 5.2 | -5.2 | 1.7e-07 | -0.22 | 0.85 | 0.10 | FALSE |
| 5 | GTEx | Testis | GRIK5 | 0.41 | 0.24 | lasso | 10 | 0.24 | 7.9e-11 | 7.7 | -7.2 | 4.9e-13 | -0.90 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZNF574 | 0.02 | 0.01 | lasso | 2 | 0.02 | 1.1e-04 | -6.6 | 9.3 | 1.5e-20 | 0.54 | 0.01 | 0.34 | TRUE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DEDD2 | 0.02 | 0.02 | lasso | 1 | 0.01 | 3.1e-02 | 7.7 | -7.7 | 1.3e-14 | -0.90 | 0.02 | 0.89 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RABAC1 | 0.01 | 0.01 | enet | 2 | 0.01 | 1.8e-02 | 4.7 | -5.3 | 1.3e-07 | -0.70 | 0.00 | 0.44 | FALSE |
| 9 | The Cancer Genome Atlas | Rectum Adenocarcinoma | GSK3A | 0.15 | 0.10 | lasso | 7 | 0.09 | 4.0e-03 | 8.2 | 8.2 | 1.7e-16 | 0.98 | 0.00 | 0.55 | FALSE |