Best TWAS P=2.21e-101 · Best GWAS P=4.12e-142 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Coronary | CTC-471F3.6 | 0.26 | -0.01 | enet | 22 | 0.04 | 1.9e-02 | 0.14 | 12.7 | 3.6e-37 | -0.48 | 0.03 | 0.50 | FALSE |
| 2 | GTEx | Brain Cerebellum | PAF1 | 0.24 | -0.01 | enet | 12 | -0.01 | 9.2e-01 | -3.99 | -5.4 | 7.8e-08 | 0.13 | 0.05 | 0.06 | FALSE |
| 3 | GTEx | Esophagus Mucosa | EID2B | 0.19 | 0.01 | enet | 19 | 0.01 | 6.7e-02 | -3.92 | 6.3 | 2.4e-10 | -0.21 | 0.06 | 0.07 | TRUE |
| 4 | GTEx | Esophagus Mucosa | CTB-60E11.9 | 0.12 | 0.00 | enet | 22 | 0.01 | 1.0e-01 | -3.92 | 12.2 | 3.3e-34 | -0.44 | 0.04 | 0.31 | TRUE |
| 5 | GTEx | Liver | SUPT5H | 0.39 | 0.21 | enet | 26 | 0.28 | 2.5e-08 | -22.24 | 17.9 | 9.3e-72 | -0.59 | 0.09 | 0.72 | TRUE |
| 6 | GTEx | Nerve Tibial | SAMD4B | 0.10 | 0.04 | lasso | 3 | 0.01 | 3.2e-02 | 8.18 | 7.8 | 4.6e-15 | -0.31 | 0.36 | 0.03 | FALSE |
| 7 | GTEx | Pituitary | ZNF780A | 0.35 | 0.02 | enet | 29 | 0.06 | 1.2e-02 | -1.05 | -6.3 | 2.5e-10 | 0.31 | 0.08 | 0.14 | FALSE |
| 8 | GTEx | Prostate | MAP3K10 | 0.33 | 0.14 | lasso | 12 | 0.21 | 6.7e-06 | -24.49 | -21.4 | 2.2e-101 | 0.79 | 0.02 | 0.89 | TRUE |
| 9 | GTEx | Whole Blood | AC005614.5 | 0.11 | 0.06 | enet | 26 | 0.07 | 1.3e-06 | -1.09 | -6.1 | 1.1e-09 | 0.24 | 0.86 | 0.01 | TRUE |
| 10 | YFS | Blood | CLC | 0.01 | 0.00 | enet | 17 | 0.00 | 2.3e-01 | -18.13 | 14.7 | 8.3e-49 | -0.56 | 0.03 | 0.73 | TRUE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ITPKC | 0.06 | 0.02 | enet | 10 | 0.05 | 4.8e-10 | 4.59 | -5.1 | 2.8e-07 | 0.01 | 0.01 | 0.97 | TRUE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RAB4B | 0.02 | 0.00 | lasso | 6 | 0.01 | 1.5e-03 | 4.41 | -5.5 | 4.7e-08 | 0.08 | 0.03 | 0.51 | TRUE |
| 13 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | LOC400696 | 0.10 | 0.03 | enet | 11 | 0.02 | 5.7e-02 | -2.31 | -11.4 | 5.1e-30 | 0.41 | 0.01 | 0.12 | FALSE |
| 14 | The Cancer Genome Atlas | Colon Adenocarcinoma | CLC | 0.08 | 0.01 | blup | 63 | 0.02 | 2.0e-02 | -17.92 | 20.1 | 5.1e-90 | -0.82 | 0.02 | 0.58 | TRUE |
| 15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LOC400696 | 0.05 | 0.00 | blup | 48 | 0.01 | 1.4e-02 | 3.01 | -6.1 | 9.8e-10 | 0.25 | 0.02 | 0.04 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOC400696 | 0.15 | 0.02 | blup | 49 | 0.06 | 1.3e-07 | -0.77 | 8.5 | 2.2e-17 | -0.33 | 0.50 | 0.10 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SIRT2 | 0.06 | 0.01 | enet | 9 | 0.03 | 1.2e-02 | -4.36 | 5.3 | 9.4e-08 | 0.05 | 0.00 | 0.32 | TRUE |
| 18 | The Cancer Genome Atlas | Lung Adenocarcinoma | RAB4B | 0.03 | 0.00 | enet | 5 | 0.02 | 3.9e-03 | 4.66 | -5.8 | 5.7e-09 | 0.10 | 0.03 | 0.63 | TRUE |
| 19 | The Cancer Genome Atlas | Lung Adenocarcinoma | SARS2 | 0.03 | 0.03 | blup | 55 | 0.03 | 5.5e-04 | -4.27 | -5.3 | 1.2e-07 | -0.03 | 0.03 | 0.80 | FALSE |
| 20 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | LOC400696 | 0.08 | 0.01 | blup | 48 | 0.04 | 3.6e-05 | 13.35 | -11.9 | 1.7e-32 | 0.46 | 0.28 | 0.16 | TRUE |
| 21 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RAB4B | 0.06 | 0.02 | blup | 58 | 0.02 | 1.7e-02 | 4.57 | -5.8 | 5.7e-09 | 0.09 | 0.01 | 0.89 | TRUE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RAB4B | 0.07 | 0.04 | blup | 57 | 0.05 | 2.0e-06 | 4.41 | -5.3 | 1.1e-07 | 0.08 | 0.08 | 0.86 | TRUE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC400696 | 0.30 | 0.03 | enet | 12 | 0.12 | 9.7e-12 | -0.77 | -6.7 | 2.4e-11 | 0.30 | 0.58 | 0.05 | TRUE |