Hub : Genes

GSK3A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 YFS Blood 0.0230 0.0130 0.0110 0.010 0.000 0.008 0.004 0.006 0.00017 0.4800 0.0007 0.01 0.0039
2 TCGA Kidney Renal Clear Cell Carcinoma 0.0278 0.0193 0.0093 0.004 0.012 0.011 NA 0.001 0.09300 0.0140 0.0170 NA 0.2200
3 TCGA Rectum Adenocarcinoma 0.1510 0.0820 0.0087 0.098 0.074 0.030 NA 0.090 0.00270 0.0085 0.0680 NA 0.0040

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.7 1.2 2.1 0.0 -1.2 -1.4
Bipolar Disorder or Schizophrenia 0.0 0.1 0.3 0.0 -0.5 -0.1
Depressed Affect (Nagel 2018) 0.2 0.3 0.6 -0.2 -0.8 -0.6
Depression (Nagel 2018) 0.6 0.8 1.7 0.3 -1.3 -0.9
Intelligence (Savage-Jansen 2018) 0.4 1.2 2.3 0.9 -0.7 -1.5
Neuroticism (Nagel 2018) 0.2 0.4 0.7 0.8 -0.4 -0.6
Schizophrenia (2018) 0.3 0.7 1.1 -0.9 0.3 1.0
Schizophrenia vs Biploar Disorder 1.2 1.6 4.1 0.0 0.9 2.0
Worry (Nagel 2018) 0.1 0.3 0.7 0.8 0.2 -0.4
Alzheimer’s Disease (in mother) 0.7 0.8 1.5 -0.9 -0.2 -1.2
Alzheimer’s Disease (in father) 0.5 0.5 1.0 -0.6 1.0 -0.5
Alzheimer’s Disease (including proxy) 0.5 0.8 1.0 -0.9 0.6 -1.0
Crohns Disease (2017) 0.9 2.1 3.4 -1.9 1.1 1.3
Irritable Bowel Disease (IBD) 1.1 2.6 4.0 -2.0 1.4 1.3
Ulcerative Colitis (UC) 0.9 1.7 2.9 -1.7 1.2 1.0
Major Depression (MDD) 0.8 1.0 2.6 0.0 -0.6 -1.6
Reaction Time 0.9 1.8 2.9 1.5 -0.5 -1.7
Verbal and Numeric Reasoning (VNR) 0.4 0.9 2.1 0.6 -0.4 -1.4
Breast Cancer 2.5 6.1 9.2 -1.1 -2.8 -3.0
Ovarian Cancer 0.4 0.5 0.8 0.8 -0.3 -0.9
Prostate Cancer 4.5 6.3 8.6 2.9 -1.9 -2.6
Age at First Birth 0.9 1.4 2.5 -1.6 1.2 0.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.7 2.0 -1.4 0.0 0.0
Coronary Artery Disease (CAD) 0.0 0.0 0.1 0.0 -0.4 0.0
Crohns Disease (2012) 0.1 0.2 0.6 0.0 0.0 0.7
Mean Putamen Volume 0.2 0.3 0.6 -0.0 -0.4 -0.8
Fasting Glucose 1.9 2.3 4.3 -2.1 -1.5 -0.6
HbA1C 0.8 0.8 1.4 -0.2 -1.0 -1.2
HDL Cholesterol 0.8 1.4 4.2 2.0 0.0 0.0
LDL Cholesterol 0.1 0.1 0.3 0.6 0.0 0.0
Lupus 1.1 1.6 2.8 -1.7 -0.9 -1.2
Neuroticism (2016) 0.7 1.0 1.2 0.9 -1.0 -1.1
Primary Biliary Cirrhosis 0.4 0.5 1.6 -1.2 -0.1 -0.2
Rheumatoid Arthritis 2.7 3.8 7.2 0.0 2.7 2.0
Schizophrenia (2014) 1.1 2.4 4.1 -1.2 1.2 2.0
Triglycerides 0.1 0.1 0.4 -0.6 0.0 0.0
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.2 -0.4 0.0 0.0
Ulcerative Colitis 0.9 1.3 2.9 0.0 1.0 1.7
Blood Eosinophil Count 4.3 33.4 67.9 -2.7 5.0 8.2
Blood Platelet Count 1.0 12.0 20.0 -2.5 4.5 3.1
Blood Red Count 0.6 5.9 6.9 -2.1 2.6 2.5
Blood White Count 5.3 39.6 63.4 -3.0 6.8 8.0
Heel T-Score 0.4 2.8 7.6 0.4 2.8 0.8
BMI 2.1 12.2 20.1 -1.9 3.5 4.5
Height 2.9 55.6 84.8 2.2 -9.2 -8.8
Waist Hip Ratio (WHR) 2.2 10.0 23.8 -0.5 -4.9 -2.4
Systolic Blood Pressure 0.6 3.3 5.7 -0.9 1.8 2.4
Smoking Status 0.3 0.6 1.0 -1.0 0.2 0.9
Allergy or Eczema 2.6 6.8 9.6 -3.1 2.4 2.2
Cardiovascular Disease 0.9 3.0 5.2 -1.6 1.2 2.3
Hypothyroidism (self reported) 0.4 0.8 2.3 0.5 -1.5 0.1
Respiratory disease 0.8 1.8 2.6 -1.6 1.2 1.2
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.4 -0.7 -0.0 0.3
Lung FEV1/FVC ratio 0.5 2.7 3.4 1.7 -1.4 -1.9
Lung FVC 2.5 12.8 24.2 1.4 -3.5 -4.9
Neuroticism 0.5 1.3 3.0 0.7 -0.6 -1.7
Chronotype (morning person) 4.0 9.3 17.6 2.1 -2.4 -4.2
Hair Pigment 0.3 8.8 14.6 0.1 -3.5 -3.8
Tanning 0.4 4.7 10.1 -1.1 1.7 3.2
Hand grip strength (left) 0.8 2.0 5.1 -0.7 -0.7 -2.3
Number of treatments/medications taken 0.2 0.3 0.6 0.5 0.1 0.8
Average weekly spirits intake 0.7 0.9 1.7 1.3 0.5 0.8
Sensitivity / hurt feelings 0.6 1.1 1.7 1.2 -0.3 -1.3
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.9 0.1 -0.9 -0.1
Hearing difficulty/problems: Yes 1.2 1.8 1.9 -1.3 1.4 1.3
Relative age of first facial hair 6.4 13.2 18.4 2.4 -4.3 -3.9
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.1 -0.4 -0.3 -0.2
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.0 -1.0 1.0 0.6
Ever had hysterectomy (womb removed) 0.5 0.6 1.3 -0.3 0.5 1.1
Systolic blood pressure, automated reading 1.1 3.2 5.4 -0.3 2.0 2.3
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.2 -0.5 -0.5 -0.5
Angina 0.3 0.3 0.6 -0.8 -0.6 -0.3
Medication for hormone replacement therapy 0.8 0.9 1.2 -1.1 -0.7 1.0
Vitamin and mineral supplements 0.6 0.8 1.4 -0.4 -0.9 1.2
Supplements: Zinc 0.6 0.6 0.9 0.9 0.1 -1.0
Medication: Co-codamol 2.1 2.4 6.0 2.4 -0.9 -0.7
Medication: Metformin 0.1 0.1 0.4 0.6 -0.0 0.2
Diabetes (father) 0.2 0.3 0.6 0.8 0.3 0.4
Diabetes (mother) 0.4 0.6 1.1 -1.0 -0.1 0.8
Severe depression (siblings) 0.7 0.8 1.9 -1.4 0.1 -0.7
Pack years adult smoking proportion 4.1 6.3 12.0 -0.1 2.6 3.5
Impedance of leg (right) 0.1 0.2 0.5 0.2 -0.7 -0.5
Leg fat-free mass (left) 0.3 1.5 2.5 -0.3 -1.3 -1.6
Trunk fat percentage 1.4 5.6 11.7 -1.0 2.0 3.4
Hand grip strength (right) 1.1 3.0 4.8 -1.0 -1.8 -2.2
Townsend deprivation index at recruitment 0.6 0.9 1.2 -0.7 -1.1 -1.0
Current tobacco smoking 1.0 1.6 3.8 -0.8 0.6 2.0
Average weekly fortified wine intake 0.2 0.2 0.4 0.2 -0.3 -0.7
Maternal smoking around birth 0.1 0.2 0.4 -0.3 0.4 0.6
Fed-up feelings 0.5 0.9 1.5 -0.2 -1.1 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.6 -0.8 -0.1 -0.1
Relative age voice broke 0.1 0.1 0.3 -0.2 -0.4 -0.5
Taking other prescription medications 0.3 0.4 1.1 -1.1 0.1 0.4
Age when periods started (menarche) 0.5 1.2 1.8 0.7 -1.1 -1.4
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.8 0.4 -0.9 0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.2 1.1 1.0 0.2
Tinnitus: Yes, but not now, but have in the past 4.0 4.3 8.8 -1.0 1.8 3.0
Qualifications: CSEs or equivalent 2.2 2.9 5.8 0.3 1.7 2.4
Serious illness, injury or assault to yourself 0.5 0.6 1.2 -1.1 -0.6 0.4
High blood pressure 2.0 5.5 11.4 -0.3 2.2 3.4
Hayfever, allergic rhinitis or eczema 2.1 4.5 5.5 -1.8 2.4 2.2
Multivitamins +/- minerals 0.9 1.1 1.9 0.9 0.8 -1.4
Stomach or abdominal pain in last month 0.2 0.2 0.5 0.4 0.0 0.7
Supplements: Glucosamine 0.2 0.3 0.7 -0.1 0.3 -0.8
Diverticular disease/diverticulitis (self-reported) 1.5 1.7 4.5 2.1 -0.1 -0.8
Medication: Atenolol 1.4 1.8 2.6 -1.3 1.0 1.6
Medication: Levothyroxine sodium 0.2 0.3 0.4 0.5 -0.6 0.5
Sitting height 2.8 20.1 33.0 3.1 -4.2 -5.7
Chronic bronchitis/emphysema (father) 0.5 0.6 1.1 0.7 -0.3 1.1
High blood pressure (mother) 0.7 0.9 1.8 0.8 1.3 0.6
Body mass index (BMI) 2.3 9.9 17.6 -1.6 3.1 4.2
Impedance of leg (left) 0.0 0.1 0.2 0.5 -0.1 0.3
Leg predicted mass (left) 0.3 1.5 2.5 -0.3 -1.4 -1.6
Trunk fat mass 0.7 3.2 6.5 -0.9 1.5 2.5
Waist circumference 0.5 1.7 3.2 -1.2 0.7 1.8
Number of incorrect matches in round 0.6 1.0 2.3 0.5 1.5 0.8
Past tobacco smoking 0.6 1.1 3.1 1.8 0.4 0.2
Alcohol usually taken with meals 2.2 3.5 5.7 0.4 -2.1 -2.4
Nervous feelings 0.4 0.7 1.5 1.2 -0.6 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.8 -0.1 -0.3 -1.3
Hearing difficulty/problems with background noise 2.7 4.3 8.5 -0.1 2.1 2.9
Hair/balding pattern: Pattern 2 0.7 0.8 2.0 -0.4 1.4 0.5
Had menopause 0.1 0.2 0.3 -0.2 -0.5 0.5
Had other major operations 0.5 0.6 1.3 1.2 -0.6 -0.1
Forced vital capacity (FVC) 5.8 22.5 42.1 0.4 -5.0 -6.5
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 2.7 0.2 1.6 0.8
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 0.9 0.3 0.8 0.9
Qualifications: None of the above 1.1 2.4 4.8 -1.4 0.6 2.2
Financial difficulties in last 2 years 0.2 0.3 0.8 -0.1 -0.2 -0.9
Mouth/teeth dental problems 0.3 0.4 1.0 -0.2 -1.0 0.5
Heart attack 0.2 0.2 0.6 -0.8 0.3 0.2
Allergy 2.1 4.8 5.6 2.2 -2.0 -2.4
Pain all over the body in last month 0.4 0.5 0.9 -0.7 0.2 1.0
Diabetes (self-reported) 0.1 0.2 0.3 0.2 -0.4 0.5
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.2 -0.2 -0.5 -0.1
Medication: Ramipril 1.0 1.3 2.9 -0.3 1.0 1.7
Medication: Simvastatin 0.2 0.3 0.5 -0.6 0.2 0.7
Fluid intelligence score 0.7 1.5 3.4 -0.2 -1.0 -1.9
Illnesses of siblings 1.9 2.6 4.4 1.0 -1.5 -2.1
Neuroticism score 0.2 0.5 0.9 -0.7 -0.2 -1.0
Weight 0.1 0.6 1.1 -0.7 0.4 1.1
Impedance of arm (right) 0.1 0.4 0.6 0.2 -0.8 -0.7
Arm fat percentage (right) 2.2 8.8 16.6 -1.6 2.7 4.1
Trunk fat-free mass 0.6 3.5 6.8 -0.6 -1.9 -2.6
Hip circumference 0.7 2.9 4.2 -0.9 2.1 1.9
Time employed in main current job 0.6 0.7 1.9 0.1 -1.4 -0.3
Alcohol intake versus 10 years previously 0.2 0.4 0.9 -0.5 0.1 0.9
Father’s age at death 0.1 0.2 0.2 0.4 0.5 0.4
Worrier / anxious feelings 1.6 3.1 6.7 0.6 -1.5 -2.6
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 1.4 1.2 0.4 0.7
Falls in the last year 0.3 0.4 1.2 -0.1 0.2 1.1
Hair/balding pattern: Pattern 3 0.1 0.2 0.3 0.4 -0.5 -0.2
Number of live births 0.4 0.5 1.2 -1.1 -0.3 -0.5
Forced expiratory volume in 1-second (FEV1) 5.3 17.7 34.1 1.1 -4.2 -5.8
Pulse rate 0.1 0.2 0.3 -0.2 0.6 0.6
Happiness 0.7 0.8 1.7 1.3 0.7 -0.6
Noisy workplace 6.9 8.5 16.4 -0.9 2.9 4.1
Qualifications: A levels/AS levels or equivalent 0.2 0.5 1.1 0.3 0.6 -1.0
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 2.3 -1.5 -0.6 -0.4
Mouth/teeth dental problems: Dentures 0.1 0.2 0.5 0.7 0.2 0.0
Asthma 0.5 1.0 1.7 -1.3 0.8 0.7
Medication: Ibuprofen (e.g. Nurofen) 2.5 3.1 6.6 0.1 1.7 2.6
Medication: Cholesterol lowering 0.3 0.4 0.8 0.6 0.3 0.9
Depression (self-reported) 1.6 1.9 4.1 1.2 -0.5 -2.0
Medication: Lansoprazole 1.0 1.2 1.6 0.8 -1.3 1.1
Prospective memory result 0.1 0.1 0.1 0.3 -0.3 -0.1
Lung cancer (father) 0.8 0.9 1.9 -0.5 0.7 1.4
Illnesses of mother 0.5 0.6 1.7 1.3 -0.4 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 5.3 16.9 30.9 0.6 -4.4 -5.6
Pulse wave Arterial Stiffness index 1.1 1.3 2.3 0.0 1.5 1.3
Impedance of arm (left) 0.3 1.3 1.6 1.2 -1.3 -0.9
Arm fat mass (right) 1.3 5.2 9.4 -1.6 1.8 3.1
Trunk predicted mass 0.6 3.5 6.7 -0.6 -1.9 -2.6
Standing height 2.5 24.9 40.2 1.8 -5.6 -6.3
Length of working week for main job 1.2 1.4 2.8 1.7 -0.6 0.9
Exposure to tobacco smoke at home 0.1 0.2 0.2 0.5 -0.5 -0.2
Breastfed as a baby 0.2 0.3 0.5 0.1 0.5 0.7
Tense / ‘highly strung’ 0.7 1.1 2.2 -0.5 0.9 1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 1.0 2.2 0.7 -0.4 -1.5
Hair/balding pattern: Pattern 4 4.9 11.9 18.8 -2.0 4.3 3.6
Birth weight of first child 1.8 3.3 6.6 0.5 -1.8 -2.6
Peak expiratory flow (PEF) 1.6 3.7 8.7 1.2 -1.0 -2.9
Pulse wave reflection index 1.4 1.7 3.9 0.2 2.0 1.1
Ever highly irritable/argumentative for 2 days 3.2 3.9 6.0 -0.6 2.5 2.3
Loud music exposure frequency 0.6 0.6 1.1 0.3 0.9 1.0
Qualifications: O levels/GCSEs or equivalent 2.0 3.2 6.2 2.5 1.3 -1.4
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.0 -0.9 1.0 -0.1
Blood clot in the leg (DVT) 0.1 0.1 0.1 0.2 0.4 -0.2
Medication: Paracetamol 0.3 0.6 1.3 0.5 0.4 1.1
Headache pain in last month 0.8 1.3 2.2 -0.1 -1.5 -1.3
Medication for cholesterol, blood pressure or diabetes 2.2 3.6 7.5 0.3 -1.8 -2.7
Glaucoma (self-reported) 2.7 3.1 8.0 -2.8 0.6 1.0
Gout (self-reported) 0.3 0.4 1.1 0.1 0.1 1.0
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.8 0.5 -0.9 0.3
Medication: Amlodipine 0.5 0.7 1.1 -0.9 0.4 1.0
Medication: Ventolin 100micrograms inhaler 0.8 1.1 1.8 -0.5 1.1 1.4
Birth weight 3.7 7.9 16.4 2.2 -1.6 -4.0
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.2 -1.1 0.2 0.5
High blood pressure (siblings) 3.0 4.3 6.7 -1.5 2.0 2.6
Forced vital capacity (FVC), Best measure 5.5 20.1 36.1 0.3 -4.9 -6.0
Body fat percentage 2.3 9.1 18.0 -1.1 2.8 4.2
Leg fat percentage (right) 3.1 11.4 20.5 -1.4 3.4 4.5
Arm fat-free mass (right) 0.3 1.4 2.5 -0.3 -1.2 -1.6
Exposure to tobacco smoke outside home 3.3 4.4 6.5 -1.0 2.5 2.4
Comparative body size at age 10 0.8 2.1 4.3 -1.1 0.9 2.1
Number of full brothers 1.2 1.5 2.8 -1.7 0.8 1.1
Worry too long after embarrassment 1.0 1.7 2.6 0.9 -1.6 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 2.7 3.5 8.4 1.4 -0.4 -2.9
Wheeze or whistling in the chest in last year 1.8 3.2 6.4 0.6 1.7 2.5
Number of children fathered 0.0 0.0 0.0 -0.1 0.1 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 1.2 0.2 1.1 0.0
Age at first live birth 0.3 0.5 1.2 0.6 0.2 -1.1
Pulse wave peak to peak time 1.9 2.3 4.0 -0.0 -2.0 -1.7
Health satisfaction 1.3 1.6 2.9 -1.2 0.8 1.7
Shortness of breath walking on level ground 0.5 0.6 1.2 0.2 1.1 0.8
Qualifications: College or University degree 0.1 0.4 0.7 -0.3 -0.6 -0.8
Eye problems/disorders: None of the above 0.5 0.6 1.4 -0.2 0.5 1.2
Mouth/teeth dental problems: Loose teeth 0.8 1.0 2.4 0.2 -0.7 -1.6
Emphysema/chronic bronchitis 1.0 1.1 1.7 -0.6 1.1 1.3
Medication for pain relief, constipation, heartburn 0.7 1.2 2.6 -0.3 -0.9 -1.6
Neck or shoulder pain in last month 0.5 0.7 0.8 -0.9 0.7 0.9
Medication: Blood pressure 3.2 5.7 10.8 -1.0 2.3 3.3
Angina (self-reported) 0.3 0.5 0.6 -0.7 -0.8 -0.4
Migraine (self-reported) 2.4 2.9 6.7 -0.7 -1.3 -2.6
Medication: Ibuprofen 2.1 2.5 5.0 0.8 1.4 2.2
Medication: Allopurinol 0.5 0.7 1.7 0.4 -0.6 1.3
Medication: Omeprazole 0.8 0.9 2.0 1.4 -0.1 -0.9
Medication: Seretide 50 evohaler 1.0 1.2 2.7 1.6 0.3 0.8
Mean time to correctly identify matches 0.6 1.1 3.1 1.8 0.2 -0.4
Heart disease (mother) 0.3 0.4 0.7 0.6 -0.9 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.7 4.6 -0.4 0.6 2.1
Whole body fat mass 1.1 4.8 9.3 -0.9 2.0 3.0
Leg fat mass (right) 1.6 6.3 11.3 -1.3 2.4 3.4
Arm predicted mass (right) 0.3 1.6 2.6 0.0 -1.5 -1.6
Pulse rate, automated reading 0.4 1.4 3.8 2.0 0.2 -0.4
Alcohol intake frequency. 3.1 7.3 13.0 -0.4 -3.6 -3.0
Comparative height size at age 10 1.4 7.5 12.0 0.9 -3.1 -3.5
Number of full sisters 0.3 0.3 0.6 0.8 0.7 -0.1
Suffer from ‘nerves’ 0.2 0.4 1.0 0.1 1.0 0.3
Overall health rating 0.7 1.5 3.2 0.5 1.0 1.8
Chest pain or discomfort 1.5 2.2 6.3 -2.5 -0.2 0.4
Had major operations 1.2 1.4 4.3 -2.1 0.0 -0.1
Age at last live birth 1.3 1.9 4.6 0.3 -1.0 -2.1
Family relationship satisfaction 0.4 0.5 1.5 0.3 0.0 1.2
Leg pain on walking 2.0 2.5 5.5 -0.6 1.3 2.3
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 1.4 1.0 1.2 0.6
Commuting to job workplace: Car/motor vehicle 2.2 2.6 6.4 0.9 0.7 2.5
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 1.7 1.3 -0.9 -0.1
Medication: Aspirin 0.1 0.1 0.2 0.4 -0.3 0.3
Supplements: Vitamin C 0.3 0.4 0.8 -0.2 0.9 -0.6
Knee pain experienced in last month 0.9 1.4 3.4 0.4 -1.9 -0.7
Hypertension (Self-reported) 2.3 6.5 11.8 -0.1 2.8 3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 1.6 0.9 -0.4 -1.3
Illnesses of father: Heart disease 0.7 0.9 2.0 -0.8 0.3 -1.4
Illnesses of siblings: Diabetes 2.9 3.5 4.8 2.2 -1.9 -1.5
Smoking status: Previous 1.0 1.5 3.8 -1.9 -0.5 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.6 2.6 0.8 -1.2 -1.6
Whole body fat-free mass 0.4 2.3 4.3 -0.3 -1.6 -2.1
Leg fat-free mass (right) 0.3 1.4 2.3 0.0 -1.4 -1.5
Arm fat percentage (left) 2.2 8.6 16.9 -1.2 2.7 4.1
Average weekly red wine intake 1.3 1.9 3.6 -0.6 -1.3 -1.9
Handedness (chirality/laterality): Left-handed 0.4 0.5 0.9 -0.9 0.5 -0.6
Mood swings 0.2 0.3 0.9 -1.0 0.1 0.0
Loneliness, isolation 0.6 0.9 1.4 -1.1 0.3 1.2
Long-standing illness, disability or infirmity 0.5 0.8 1.8 0.5 -1.3 -0.6
Ever had bowel cancer screening 0.5 0.6 1.0 0.8 -0.4 -1.0
Diabetes diagnosed by doctor 0.4 0.7 1.2 1.1 -0.9 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.3 0.4 0.5 0.3 -0.7
Friendships satisfaction 0.4 0.5 0.9 0.7 -0.9 0.5
Qualifications: nursing, teaching 4.7 7.2 11.8 2.6 -1.7 -3.4
Commuting to job workplace: Walk 1.8 1.9 4.5 2.1 -0.7 -0.9
Eye problems/disorders: Cataract 0.5 0.6 1.4 1.2 -0.7 -0.1
Mouth/teeth dental problems: Mouth ulcers 1.8 2.8 4.3 2.0 -0.2 -2.1
Medication for cholesterol 0.3 0.4 0.4 0.6 0.6 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.0 5.3 2.3 -0.7 -0.3
Back pain experienced in last month 0.1 0.2 0.3 -0.4 -0.5 0.2
Mineral and other dietary supplements 1.1 1.4 4.1 -0.0 0.5 2.0
Breast cancer (self-reported) 0.9 1.1 2.7 0.0 -0.7 -1.6
Asthma (self-reported) 0.3 0.5 0.7 -0.9 0.7 0.6
Osteoporosis (self-reported) 1.2 1.5 2.5 -1.1 -1.6 -0.8
Osteoarthritis (self-reported) 1.0 1.3 1.4 1.2 -1.0 -1.2
Medication: Aspirin 0.1 0.1 0.3 0.2 -0.5 0.1
Medication: Gliclazide 0.2 0.2 0.6 -0.0 -0.3 0.8
Illnesses of father: None of the above (group 1) 0.4 0.5 1.6 -1.3 -0.2 0.1
Smoking status: Current 0.7 1.1 2.6 -0.6 0.6 1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.6 5.6 10.8 0.0 -2.4 -3.3
Whole body water mass 0.5 2.8 5.0 -0.4 -1.8 -2.2
Leg predicted mass (right) 0.3 1.4 2.4 0.1 -1.4 -1.5
Arm fat mass (left) 1.3 5.3 10.1 -1.3 2.0 3.2
Number of self-reported non-cancer illnesses 0.6 1.0 1.8 -0.7 -1.3 -0.8
Average weekly champagne plus white wine intake 0.5 0.7 1.6 -1.3 0.0 -0.7
Miserableness 0.4 0.7 1.3 -0.1 -1.1 -0.9
Guilty feelings 0.6 0.9 1.7 -1.3 1.0 -0.1
Wears glasses or contact lenses 0.2 0.2 0.4 0.2 -0.6 -0.4
Ever taken oral contraceptive pill 0.4 0.4 1.1 1.1 -0.2 -0.0
Hearing aid user 2.0 2.3 3.4 -1.0 1.8 1.5
Mother’s age at death 0.4 0.5 0.9 -1.0 0.3 -0.7
Financial situation satisfaction 0.7 0.9 1.0 -0.9 0.9 1.0
Tinnitus: Yes, now most or all of the time 3.3 3.8 6.8 -0.8 2.0 2.6
Commuting to job workplace: Public transport 1.1 1.3 2.3 0.7 -1.0 -1.5
Eye problems/disorders: Glaucoma 2.6 3.0 8.9 -3.0 0.4 0.3
Medication: Blood pressure 0.1 0.2 0.2 0.3 0.4 0.5
Pain type(s) experienced in last month: Hip pain 0.8 1.1 1.8 1.1 0.3 1.4
Supplements: Fish oil (including cod liver oil) 1.0 1.3 3.5 0.1 -0.6 -1.9
High cholesterol (Self-reported) 0.1 0.3 0.5 -0.7 -0.6 -0.1
Medication: Bendroflumethiazide 0.6 0.9 1.8 0.3 1.4 0.9
Medication: Paracetamol 0.6 1.0 2.1 0.7 0.6 1.4
Medication: Lisinopril 0.1 0.1 0.2 0.3 -0.4 0.2
Medication: Atorvastatin 0.6 0.7 0.9 1.0 -0.9 -0.5
Illnesses of father: High blood pressure 1.2 1.5 3.2 0.9 1.8 0.7
Alcohol drinker status: Never 2.0 2.5 6.1 0.2 -1.1 -2.5
Ever smoked 1.0 1.8 5.2 -2.3 -0.0 0.5
Basal metabolic rate 0.2 1.1 1.7 -0.6 -1.1 -1.3
Leg fat percentage (left) 3.9 14.2 26.3 -1.2 3.9 5.1
Arm fat-free mass (left) 0.2 0.9 1.2 -0.9 -0.9 -1.1
Number of operations (self-reported) 0.1 0.2 0.5 0.7 0.0 -0.2
Average weekly beer plus cider intake 1.5 2.2 3.7 0.3 1.9 1.7
Irritability 0.5 0.8 2.0 0.1 1.4 0.7
Risk taking 0.1 0.1 0.2 -0.2 0.5 0.2
Ever had prostate specific antigen (PSA) test 1.2 1.3 2.5 1.0 0.7 -1.6
Fractured/broken bones in last 5 years 0.2 0.2 0.4 0.6 -0.1 0.6
Age started oral contraceptive pill 0.2 0.3 0.8 0.9 0.1 0.3
Diastolic blood pressure, automated reading 0.7 2.0 3.6 -0.2 1.9 1.6
Ever depressed for a whole week 0.7 0.9 1.1 -0.8 0.9 1.1
Unable to work because of sickness or disability 0.3 0.4 0.9 0.2 0.9 0.6
Commuting to job workplace: Cycle 3.0 3.6 7.0 1.1 -1.6 -2.6
Myopia 2.7 3.9 7.6 2.8 -1.7 -1.2
Vascular/heart problems diagnosed by doctor 1.2 3.2 8.0 0.3 -1.2 -2.8
Cholesterol lowering medication 0.4 0.6 0.8 -0.7 -0.9 -0.6
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 0.9 -0.1 -1.0 -0.8
Pain experienced in last month 0.5 0.8 2.0 0.2 0.5 -1.4
Supplements: Calcium 2.7 3.0 8.6 -2.9 0.4 -0.5
Basal cell carcinoma (self-reported) 1.3 1.6 2.6 0.3 1.4 1.6
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.1 -1.1 0.2 0.2
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.7 0.2 0.8 0.0
Heart disease (siblings) 1.0 1.2 3.5 -1.9 -0.4 0.2
Alcohol drinker status: Previous 2.4 2.7 5.3 -0.2 -1.6 -2.3
Pack years of smoking 5.2 7.7 13.5 0.1 3.1 3.7
Impedance of whole body 0.2 0.8 1.1 1.0 -0.9 -0.6
Leg fat mass (left) 1.8 7.2 13.1 -1.2 2.6 3.6
Arm predicted mass (left) 0.1 0.6 0.8 -0.8 -0.7 -0.9