Hub : Genes

GSK3A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0230	0.0130	0.0110	0.010	0.000	0.008	0.004	0.006	0.00017	0.4800	0.0007	0.01	0.0039
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0278	0.0193	0.0093	0.004	0.012	0.011	NA	0.001	0.09300	0.0140	0.0170	NA	0.2200
3	TCGA	Rectum Adenocarcinoma	0.1510	0.0820	0.0087	0.098	0.074	0.030	NA	0.090	0.00270	0.0085	0.0680	NA	0.0040

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.7	1.2	2.1	0.0	-1.2	-1.4
Bipolar Disorder or Schizophrenia	0.0	0.1	0.3	0.0	-0.5	-0.1
Depressed Affect (Nagel 2018)	0.2	0.3	0.6	-0.2	-0.8	-0.6
Depression (Nagel 2018)	0.6	0.8	1.7	0.3	-1.3	-0.9
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.3	0.9	-0.7	-1.5
Neuroticism (Nagel 2018)	0.2	0.4	0.7	0.8	-0.4	-0.6
Schizophrenia (2018)	0.3	0.7	1.1	-0.9	0.3	1.0
Schizophrenia vs Biploar Disorder	1.2	1.6	4.1	0.0	0.9	2.0
Worry (Nagel 2018)	0.1	0.3	0.7	0.8	0.2	-0.4
Alzheimer’s Disease (in mother)	0.7	0.8	1.5	-0.9	-0.2	-1.2
Alzheimer’s Disease (in father)	0.5	0.5	1.0	-0.6	1.0	-0.5
Alzheimer’s Disease (including proxy)	0.5	0.8	1.0	-0.9	0.6	-1.0
Crohns Disease (2017)	0.9	2.1	3.4	-1.9	1.1	1.3
Irritable Bowel Disease (IBD)	1.1	2.6	4.0	-2.0	1.4	1.3
Ulcerative Colitis (UC)	0.9	1.7	2.9	-1.7	1.2	1.0
Major Depression (MDD)	0.8	1.0	2.6	0.0	-0.6	-1.6
Reaction Time	0.9	1.8	2.9	1.5	-0.5	-1.7
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.1	0.6	-0.4	-1.4
Breast Cancer	2.5	6.1	9.2	-1.1	-2.8	-3.0
Ovarian Cancer	0.4	0.5	0.8	0.8	-0.3	-0.9
Prostate Cancer	4.5	6.3	8.6	2.9	-1.9	-2.6
Age at First Birth	0.9	1.4	2.5	-1.6	1.2	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	2.0	-1.4	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.1	0.0	-0.4	0.0
Crohns Disease (2012)	0.1	0.2	0.6	0.0	0.0	0.7
Mean Putamen Volume	0.2	0.3	0.6	-0.0	-0.4	-0.8
Fasting Glucose	1.9	2.3	4.3	-2.1	-1.5	-0.6
HbA1C	0.8	0.8	1.4	-0.2	-1.0	-1.2
HDL Cholesterol	0.8	1.4	4.2	2.0	0.0	0.0
LDL Cholesterol	0.1	0.1	0.3	0.6	0.0	0.0
Lupus	1.1	1.6	2.8	-1.7	-0.9	-1.2
Neuroticism (2016)	0.7	1.0	1.2	0.9	-1.0	-1.1
Primary Biliary Cirrhosis	0.4	0.5	1.6	-1.2	-0.1	-0.2
Rheumatoid Arthritis	2.7	3.8	7.2	0.0	2.7	2.0
Schizophrenia (2014)	1.1	2.4	4.1	-1.2	1.2	2.0
Triglycerides	0.1	0.1	0.4	-0.6	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	-0.4	0.0	0.0
Ulcerative Colitis	0.9	1.3	2.9	0.0	1.0	1.7
Blood Eosinophil Count	4.3	33.4	67.9	-2.7	5.0	8.2
Blood Platelet Count	1.0	12.0	20.0	-2.5	4.5	3.1
Blood Red Count	0.6	5.9	6.9	-2.1	2.6	2.5
Blood White Count	5.3	39.6	63.4	-3.0	6.8	8.0
Heel T-Score	0.4	2.8	7.6	0.4	2.8	0.8
BMI	2.1	12.2	20.1	-1.9	3.5	4.5
Height	2.9	55.6	84.8	2.2	-9.2	-8.8
Waist Hip Ratio (WHR)	2.2	10.0	23.8	-0.5	-4.9	-2.4
Systolic Blood Pressure	0.6	3.3	5.7	-0.9	1.8	2.4
Smoking Status	0.3	0.6	1.0	-1.0	0.2	0.9
Allergy or Eczema	2.6	6.8	9.6	-3.1	2.4	2.2
Cardiovascular Disease	0.9	3.0	5.2	-1.6	1.2	2.3
Hypothyroidism (self reported)	0.4	0.8	2.3	0.5	-1.5	0.1
Respiratory disease	0.8	1.8	2.6	-1.6	1.2	1.2
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	-0.7	-0.0	0.3
Lung FEV1/FVC ratio	0.5	2.7	3.4	1.7	-1.4	-1.9
Lung FVC	2.5	12.8	24.2	1.4	-3.5	-4.9
Neuroticism	0.5	1.3	3.0	0.7	-0.6	-1.7
Chronotype (morning person)	4.0	9.3	17.6	2.1	-2.4	-4.2
Hair Pigment	0.3	8.8	14.6	0.1	-3.5	-3.8
Tanning	0.4	4.7	10.1	-1.1	1.7	3.2
Hand grip strength (left)	0.8	2.0	5.1	-0.7	-0.7	-2.3
Number of treatments/medications taken	0.2	0.3	0.6	0.5	0.1	0.8
Average weekly spirits intake	0.7	0.9	1.7	1.3	0.5	0.8
Sensitivity / hurt feelings	0.6	1.1	1.7	1.2	-0.3	-1.3
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.9	0.1	-0.9	-0.1
Hearing difficulty/problems: Yes	1.2	1.8	1.9	-1.3	1.4	1.3
Relative age of first facial hair	6.4	13.2	18.4	2.4	-4.3	-3.9
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.1	-0.4	-0.3	-0.2
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.0	-1.0	1.0	0.6
Ever had hysterectomy (womb removed)	0.5	0.6	1.3	-0.3	0.5	1.1
Systolic blood pressure, automated reading	1.1	3.2	5.4	-0.3	2.0	2.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.2	-0.5	-0.5	-0.5
Angina	0.3	0.3	0.6	-0.8	-0.6	-0.3
Medication for hormone replacement therapy	0.8	0.9	1.2	-1.1	-0.7	1.0
Vitamin and mineral supplements	0.6	0.8	1.4	-0.4	-0.9	1.2
Supplements: Zinc	0.6	0.6	0.9	0.9	0.1	-1.0
Medication: Co-codamol	2.1	2.4	6.0	2.4	-0.9	-0.7
Medication: Metformin	0.1	0.1	0.4	0.6	-0.0	0.2
Diabetes (father)	0.2	0.3	0.6	0.8	0.3	0.4
Diabetes (mother)	0.4	0.6	1.1	-1.0	-0.1	0.8
Severe depression (siblings)	0.7	0.8	1.9	-1.4	0.1	-0.7
Pack years adult smoking proportion	4.1	6.3	12.0	-0.1	2.6	3.5
Impedance of leg (right)	0.1	0.2	0.5	0.2	-0.7	-0.5
Leg fat-free mass (left)	0.3	1.5	2.5	-0.3	-1.3	-1.6
Trunk fat percentage	1.4	5.6	11.7	-1.0	2.0	3.4
Hand grip strength (right)	1.1	3.0	4.8	-1.0	-1.8	-2.2
Townsend deprivation index at recruitment	0.6	0.9	1.2	-0.7	-1.1	-1.0
Current tobacco smoking	1.0	1.6	3.8	-0.8	0.6	2.0
Average weekly fortified wine intake	0.2	0.2	0.4	0.2	-0.3	-0.7
Maternal smoking around birth	0.1	0.2	0.4	-0.3	0.4	0.6
Fed-up feelings	0.5	0.9	1.5	-0.2	-1.1	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.6	-0.8	-0.1	-0.1
Relative age voice broke	0.1	0.1	0.3	-0.2	-0.4	-0.5
Taking other prescription medications	0.3	0.4	1.1	-1.1	0.1	0.4
Age when periods started (menarche)	0.5	1.2	1.8	0.7	-1.1	-1.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.8	0.4	-0.9	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.2	1.1	1.0	0.2
Tinnitus: Yes, but not now, but have in the past	4.0	4.3	8.8	-1.0	1.8	3.0
Qualifications: CSEs or equivalent	2.2	2.9	5.8	0.3	1.7	2.4
Serious illness, injury or assault to yourself	0.5	0.6	1.2	-1.1	-0.6	0.4
High blood pressure	2.0	5.5	11.4	-0.3	2.2	3.4
Hayfever, allergic rhinitis or eczema	2.1	4.5	5.5	-1.8	2.4	2.2
Multivitamins +/- minerals	0.9	1.1	1.9	0.9	0.8	-1.4
Stomach or abdominal pain in last month	0.2	0.2	0.5	0.4	0.0	0.7
Supplements: Glucosamine	0.2	0.3	0.7	-0.1	0.3	-0.8
Diverticular disease/diverticulitis (self-reported)	1.5	1.7	4.5	2.1	-0.1	-0.8
Medication: Atenolol	1.4	1.8	2.6	-1.3	1.0	1.6
Medication: Levothyroxine sodium	0.2	0.3	0.4	0.5	-0.6	0.5
Sitting height	2.8	20.1	33.0	3.1	-4.2	-5.7
Chronic bronchitis/emphysema (father)	0.5	0.6	1.1	0.7	-0.3	1.1
High blood pressure (mother)	0.7	0.9	1.8	0.8	1.3	0.6
Body mass index (BMI)	2.3	9.9	17.6	-1.6	3.1	4.2
Impedance of leg (left)	0.0	0.1	0.2	0.5	-0.1	0.3
Leg predicted mass (left)	0.3	1.5	2.5	-0.3	-1.4	-1.6
Trunk fat mass	0.7	3.2	6.5	-0.9	1.5	2.5
Waist circumference	0.5	1.7	3.2	-1.2	0.7	1.8
Number of incorrect matches in round	0.6	1.0	2.3	0.5	1.5	0.8
Past tobacco smoking	0.6	1.1	3.1	1.8	0.4	0.2
Alcohol usually taken with meals	2.2	3.5	5.7	0.4	-2.1	-2.4
Nervous feelings	0.4	0.7	1.5	1.2	-0.6	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.8	-0.1	-0.3	-1.3
Hearing difficulty/problems with background noise	2.7	4.3	8.5	-0.1	2.1	2.9
Hair/balding pattern: Pattern 2	0.7	0.8	2.0	-0.4	1.4	0.5
Had menopause	0.1	0.2	0.3	-0.2	-0.5	0.5
Had other major operations	0.5	0.6	1.3	1.2	-0.6	-0.1
Forced vital capacity (FVC)	5.8	22.5	42.1	0.4	-5.0	-6.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.7	0.2	1.6	0.8
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	0.9	0.3	0.8	0.9
Qualifications: None of the above	1.1	2.4	4.8	-1.4	0.6	2.2
Financial difficulties in last 2 years	0.2	0.3	0.8	-0.1	-0.2	-0.9
Mouth/teeth dental problems	0.3	0.4	1.0	-0.2	-1.0	0.5
Heart attack	0.2	0.2	0.6	-0.8	0.3	0.2
Allergy	2.1	4.8	5.6	2.2	-2.0	-2.4
Pain all over the body in last month	0.4	0.5	0.9	-0.7	0.2	1.0
Diabetes (self-reported)	0.1	0.2	0.3	0.2	-0.4	0.5
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	-0.2	-0.5	-0.1
Medication: Ramipril	1.0	1.3	2.9	-0.3	1.0	1.7
Medication: Simvastatin	0.2	0.3	0.5	-0.6	0.2	0.7
Fluid intelligence score	0.7	1.5	3.4	-0.2	-1.0	-1.9
Illnesses of siblings	1.9	2.6	4.4	1.0	-1.5	-2.1
Neuroticism score	0.2	0.5	0.9	-0.7	-0.2	-1.0
Weight	0.1	0.6	1.1	-0.7	0.4	1.1
Impedance of arm (right)	0.1	0.4	0.6	0.2	-0.8	-0.7
Arm fat percentage (right)	2.2	8.8	16.6	-1.6	2.7	4.1
Trunk fat-free mass	0.6	3.5	6.8	-0.6	-1.9	-2.6
Hip circumference	0.7	2.9	4.2	-0.9	2.1	1.9
Time employed in main current job	0.6	0.7	1.9	0.1	-1.4	-0.3
Alcohol intake versus 10 years previously	0.2	0.4	0.9	-0.5	0.1	0.9
Father’s age at death	0.1	0.2	0.2	0.4	0.5	0.4
Worrier / anxious feelings	1.6	3.1	6.7	0.6	-1.5	-2.6
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.4	1.2	0.4	0.7
Falls in the last year	0.3	0.4	1.2	-0.1	0.2	1.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	0.4	-0.5	-0.2
Number of live births	0.4	0.5	1.2	-1.1	-0.3	-0.5
Forced expiratory volume in 1-second (FEV1)	5.3	17.7	34.1	1.1	-4.2	-5.8
Pulse rate	0.1	0.2	0.3	-0.2	0.6	0.6
Happiness	0.7	0.8	1.7	1.3	0.7	-0.6
Noisy workplace	6.9	8.5	16.4	-0.9	2.9	4.1
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.1	0.3	0.6	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.3	-1.5	-0.6	-0.4
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	0.7	0.2	0.0
Asthma	0.5	1.0	1.7	-1.3	0.8	0.7
Medication: Ibuprofen (e.g. Nurofen)	2.5	3.1	6.6	0.1	1.7	2.6
Medication: Cholesterol lowering	0.3	0.4	0.8	0.6	0.3	0.9
Depression (self-reported)	1.6	1.9	4.1	1.2	-0.5	-2.0
Medication: Lansoprazole	1.0	1.2	1.6	0.8	-1.3	1.1
Prospective memory result	0.1	0.1	0.1	0.3	-0.3	-0.1
Lung cancer (father)	0.8	0.9	1.9	-0.5	0.7	1.4
Illnesses of mother	0.5	0.6	1.7	1.3	-0.4	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	5.3	16.9	30.9	0.6	-4.4	-5.6
Pulse wave Arterial Stiffness index	1.1	1.3	2.3	0.0	1.5	1.3
Impedance of arm (left)	0.3	1.3	1.6	1.2	-1.3	-0.9
Arm fat mass (right)	1.3	5.2	9.4	-1.6	1.8	3.1
Trunk predicted mass	0.6	3.5	6.7	-0.6	-1.9	-2.6
Standing height	2.5	24.9	40.2	1.8	-5.6	-6.3
Length of working week for main job	1.2	1.4	2.8	1.7	-0.6	0.9
Exposure to tobacco smoke at home	0.1	0.2	0.2	0.5	-0.5	-0.2
Breastfed as a baby	0.2	0.3	0.5	0.1	0.5	0.7
Tense / ‘highly strung’	0.7	1.1	2.2	-0.5	0.9	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.2	0.7	-0.4	-1.5
Hair/balding pattern: Pattern 4	4.9	11.9	18.8	-2.0	4.3	3.6
Birth weight of first child	1.8	3.3	6.6	0.5	-1.8	-2.6
Peak expiratory flow (PEF)	1.6	3.7	8.7	1.2	-1.0	-2.9
Pulse wave reflection index	1.4	1.7	3.9	0.2	2.0	1.1
Ever highly irritable/argumentative for 2 days	3.2	3.9	6.0	-0.6	2.5	2.3
Loud music exposure frequency	0.6	0.6	1.1	0.3	0.9	1.0
Qualifications: O levels/GCSEs or equivalent	2.0	3.2	6.2	2.5	1.3	-1.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.0	-0.9	1.0	-0.1
Blood clot in the leg (DVT)	0.1	0.1	0.1	0.2	0.4	-0.2
Medication: Paracetamol	0.3	0.6	1.3	0.5	0.4	1.1
Headache pain in last month	0.8	1.3	2.2	-0.1	-1.5	-1.3
Medication for cholesterol, blood pressure or diabetes	2.2	3.6	7.5	0.3	-1.8	-2.7
Glaucoma (self-reported)	2.7	3.1	8.0	-2.8	0.6	1.0
Gout (self-reported)	0.3	0.4	1.1	0.1	0.1	1.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	0.5	-0.9	0.3
Medication: Amlodipine	0.5	0.7	1.1	-0.9	0.4	1.0
Medication: Ventolin 100micrograms inhaler	0.8	1.1	1.8	-0.5	1.1	1.4
Birth weight	3.7	7.9	16.4	2.2	-1.6	-4.0
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.2	-1.1	0.2	0.5
High blood pressure (siblings)	3.0	4.3	6.7	-1.5	2.0	2.6
Forced vital capacity (FVC), Best measure	5.5	20.1	36.1	0.3	-4.9	-6.0
Body fat percentage	2.3	9.1	18.0	-1.1	2.8	4.2
Leg fat percentage (right)	3.1	11.4	20.5	-1.4	3.4	4.5
Arm fat-free mass (right)	0.3	1.4	2.5	-0.3	-1.2	-1.6
Exposure to tobacco smoke outside home	3.3	4.4	6.5	-1.0	2.5	2.4
Comparative body size at age 10	0.8	2.1	4.3	-1.1	0.9	2.1
Number of full brothers	1.2	1.5	2.8	-1.7	0.8	1.1
Worry too long after embarrassment	1.0	1.7	2.6	0.9	-1.6	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.7	3.5	8.4	1.4	-0.4	-2.9
Wheeze or whistling in the chest in last year	1.8	3.2	6.4	0.6	1.7	2.5
Number of children fathered	0.0	0.0	0.0	-0.1	0.1	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.2	0.2	1.1	0.0
Age at first live birth	0.3	0.5	1.2	0.6	0.2	-1.1
Pulse wave peak to peak time	1.9	2.3	4.0	-0.0	-2.0	-1.7
Health satisfaction	1.3	1.6	2.9	-1.2	0.8	1.7
Shortness of breath walking on level ground	0.5	0.6	1.2	0.2	1.1	0.8
Qualifications: College or University degree	0.1	0.4	0.7	-0.3	-0.6	-0.8
Eye problems/disorders: None of the above	0.5	0.6	1.4	-0.2	0.5	1.2
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.4	0.2	-0.7	-1.6
Emphysema/chronic bronchitis	1.0	1.1	1.7	-0.6	1.1	1.3
Medication for pain relief, constipation, heartburn	0.7	1.2	2.6	-0.3	-0.9	-1.6
Neck or shoulder pain in last month	0.5	0.7	0.8	-0.9	0.7	0.9
Medication: Blood pressure	3.2	5.7	10.8	-1.0	2.3	3.3
Angina (self-reported)	0.3	0.5	0.6	-0.7	-0.8	-0.4
Migraine (self-reported)	2.4	2.9	6.7	-0.7	-1.3	-2.6
Medication: Ibuprofen	2.1	2.5	5.0	0.8	1.4	2.2
Medication: Allopurinol	0.5	0.7	1.7	0.4	-0.6	1.3
Medication: Omeprazole	0.8	0.9	2.0	1.4	-0.1	-0.9
Medication: Seretide 50 evohaler	1.0	1.2	2.7	1.6	0.3	0.8
Mean time to correctly identify matches	0.6	1.1	3.1	1.8	0.2	-0.4
Heart disease (mother)	0.3	0.4	0.7	0.6	-0.9	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	4.6	-0.4	0.6	2.1
Whole body fat mass	1.1	4.8	9.3	-0.9	2.0	3.0
Leg fat mass (right)	1.6	6.3	11.3	-1.3	2.4	3.4
Arm predicted mass (right)	0.3	1.6	2.6	0.0	-1.5	-1.6
Pulse rate, automated reading	0.4	1.4	3.8	2.0	0.2	-0.4
Alcohol intake frequency.	3.1	7.3	13.0	-0.4	-3.6	-3.0
Comparative height size at age 10	1.4	7.5	12.0	0.9	-3.1	-3.5
Number of full sisters	0.3	0.3	0.6	0.8	0.7	-0.1
Suffer from ‘nerves’	0.2	0.4	1.0	0.1	1.0	0.3
Overall health rating	0.7	1.5	3.2	0.5	1.0	1.8
Chest pain or discomfort	1.5	2.2	6.3	-2.5	-0.2	0.4
Had major operations	1.2	1.4	4.3	-2.1	0.0	-0.1
Age at last live birth	1.3	1.9	4.6	0.3	-1.0	-2.1
Family relationship satisfaction	0.4	0.5	1.5	0.3	0.0	1.2
Leg pain on walking	2.0	2.5	5.5	-0.6	1.3	2.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.4	1.0	1.2	0.6
Commuting to job workplace: Car/motor vehicle	2.2	2.6	6.4	0.9	0.7	2.5
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.7	1.3	-0.9	-0.1
Medication: Aspirin	0.1	0.1	0.2	0.4	-0.3	0.3
Supplements: Vitamin C	0.3	0.4	0.8	-0.2	0.9	-0.6
Knee pain experienced in last month	0.9	1.4	3.4	0.4	-1.9	-0.7
Hypertension (Self-reported)	2.3	6.5	11.8	-0.1	2.8	3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.6	0.9	-0.4	-1.3
Illnesses of father: Heart disease	0.7	0.9	2.0	-0.8	0.3	-1.4
Illnesses of siblings: Diabetes	2.9	3.5	4.8	2.2	-1.9	-1.5
Smoking status: Previous	1.0	1.5	3.8	-1.9	-0.5	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	2.6	0.8	-1.2	-1.6
Whole body fat-free mass	0.4	2.3	4.3	-0.3	-1.6	-2.1
Leg fat-free mass (right)	0.3	1.4	2.3	0.0	-1.4	-1.5
Arm fat percentage (left)	2.2	8.6	16.9	-1.2	2.7	4.1
Average weekly red wine intake	1.3	1.9	3.6	-0.6	-1.3	-1.9
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.9	-0.9	0.5	-0.6
Mood swings	0.2	0.3	0.9	-1.0	0.1	0.0
Loneliness, isolation	0.6	0.9	1.4	-1.1	0.3	1.2
Long-standing illness, disability or infirmity	0.5	0.8	1.8	0.5	-1.3	-0.6
Ever had bowel cancer screening	0.5	0.6	1.0	0.8	-0.4	-1.0
Diabetes diagnosed by doctor	0.4	0.7	1.2	1.1	-0.9	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.4	0.5	0.3	-0.7
Friendships satisfaction	0.4	0.5	0.9	0.7	-0.9	0.5
Qualifications: nursing, teaching	4.7	7.2	11.8	2.6	-1.7	-3.4
Commuting to job workplace: Walk	1.8	1.9	4.5	2.1	-0.7	-0.9
Eye problems/disorders: Cataract	0.5	0.6	1.4	1.2	-0.7	-0.1
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	4.3	2.0	-0.2	-2.1
Medication for cholesterol	0.3	0.4	0.4	0.6	0.6	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	5.3	2.3	-0.7	-0.3
Back pain experienced in last month	0.1	0.2	0.3	-0.4	-0.5	0.2
Mineral and other dietary supplements	1.1	1.4	4.1	-0.0	0.5	2.0
Breast cancer (self-reported)	0.9	1.1	2.7	0.0	-0.7	-1.6
Asthma (self-reported)	0.3	0.5	0.7	-0.9	0.7	0.6
Osteoporosis (self-reported)	1.2	1.5	2.5	-1.1	-1.6	-0.8
Osteoarthritis (self-reported)	1.0	1.3	1.4	1.2	-1.0	-1.2
Medication: Aspirin	0.1	0.1	0.3	0.2	-0.5	0.1
Medication: Gliclazide	0.2	0.2	0.6	-0.0	-0.3	0.8
Illnesses of father: None of the above (group 1)	0.4	0.5	1.6	-1.3	-0.2	0.1
Smoking status: Current	0.7	1.1	2.6	-0.6	0.6	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.6	5.6	10.8	0.0	-2.4	-3.3
Whole body water mass	0.5	2.8	5.0	-0.4	-1.8	-2.2
Leg predicted mass (right)	0.3	1.4	2.4	0.1	-1.4	-1.5
Arm fat mass (left)	1.3	5.3	10.1	-1.3	2.0	3.2
Number of self-reported non-cancer illnesses	0.6	1.0	1.8	-0.7	-1.3	-0.8
Average weekly champagne plus white wine intake	0.5	0.7	1.6	-1.3	0.0	-0.7
Miserableness	0.4	0.7	1.3	-0.1	-1.1	-0.9
Guilty feelings	0.6	0.9	1.7	-1.3	1.0	-0.1
Wears glasses or contact lenses	0.2	0.2	0.4	0.2	-0.6	-0.4
Ever taken oral contraceptive pill	0.4	0.4	1.1	1.1	-0.2	-0.0
Hearing aid user	2.0	2.3	3.4	-1.0	1.8	1.5
Mother’s age at death	0.4	0.5	0.9	-1.0	0.3	-0.7
Financial situation satisfaction	0.7	0.9	1.0	-0.9	0.9	1.0
Tinnitus: Yes, now most or all of the time	3.3	3.8	6.8	-0.8	2.0	2.6
Commuting to job workplace: Public transport	1.1	1.3	2.3	0.7	-1.0	-1.5
Eye problems/disorders: Glaucoma	2.6	3.0	8.9	-3.0	0.4	0.3
Medication: Blood pressure	0.1	0.2	0.2	0.3	0.4	0.5
Pain type(s) experienced in last month: Hip pain	0.8	1.1	1.8	1.1	0.3	1.4
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.5	0.1	-0.6	-1.9
High cholesterol (Self-reported)	0.1	0.3	0.5	-0.7	-0.6	-0.1
Medication: Bendroflumethiazide	0.6	0.9	1.8	0.3	1.4	0.9
Medication: Paracetamol	0.6	1.0	2.1	0.7	0.6	1.4
Medication: Lisinopril	0.1	0.1	0.2	0.3	-0.4	0.2
Medication: Atorvastatin	0.6	0.7	0.9	1.0	-0.9	-0.5
Illnesses of father: High blood pressure	1.2	1.5	3.2	0.9	1.8	0.7
Alcohol drinker status: Never	2.0	2.5	6.1	0.2	-1.1	-2.5
Ever smoked	1.0	1.8	5.2	-2.3	-0.0	0.5
Basal metabolic rate	0.2	1.1	1.7	-0.6	-1.1	-1.3
Leg fat percentage (left)	3.9	14.2	26.3	-1.2	3.9	5.1
Arm fat-free mass (left)	0.2	0.9	1.2	-0.9	-0.9	-1.1
Number of operations (self-reported)	0.1	0.2	0.5	0.7	0.0	-0.2
Average weekly beer plus cider intake	1.5	2.2	3.7	0.3	1.9	1.7
Irritability	0.5	0.8	2.0	0.1	1.4	0.7
Risk taking	0.1	0.1	0.2	-0.2	0.5	0.2
Ever had prostate specific antigen (PSA) test	1.2	1.3	2.5	1.0	0.7	-1.6
Fractured/broken bones in last 5 years	0.2	0.2	0.4	0.6	-0.1	0.6
Age started oral contraceptive pill	0.2	0.3	0.8	0.9	0.1	0.3
Diastolic blood pressure, automated reading	0.7	2.0	3.6	-0.2	1.9	1.6
Ever depressed for a whole week	0.7	0.9	1.1	-0.8	0.9	1.1
Unable to work because of sickness or disability	0.3	0.4	0.9	0.2	0.9	0.6
Commuting to job workplace: Cycle	3.0	3.6	7.0	1.1	-1.6	-2.6
Myopia	2.7	3.9	7.6	2.8	-1.7	-1.2
Vascular/heart problems diagnosed by doctor	1.2	3.2	8.0	0.3	-1.2	-2.8
Cholesterol lowering medication	0.4	0.6	0.8	-0.7	-0.9	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	-0.1	-1.0	-0.8
Pain experienced in last month	0.5	0.8	2.0	0.2	0.5	-1.4
Supplements: Calcium	2.7	3.0	8.6	-2.9	0.4	-0.5
Basal cell carcinoma (self-reported)	1.3	1.6	2.6	0.3	1.4	1.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.1	-1.1	0.2	0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.7	0.2	0.8	0.0
Heart disease (siblings)	1.0	1.2	3.5	-1.9	-0.4	0.2
Alcohol drinker status: Previous	2.4	2.7	5.3	-0.2	-1.6	-2.3
Pack years of smoking	5.2	7.7	13.5	0.1	3.1	3.7
Impedance of whole body	0.2	0.8	1.1	1.0	-0.9	-0.6
Leg fat mass (left)	1.8	7.2	13.1	-1.2	2.6	3.6
Arm predicted mass (left)	0.1	0.6	0.8	-0.8	-0.7	-0.9