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chr19:44,649,590-48,684,812

Best TWAS P=3.09e-32 · Best GWAS P=3.12e-29 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SYMPK	0.08	0.04	enet	8	0.04	5.7e-06	-9.911	10.6	2.5e-26	0.32	0.46	0.54	FALSE
2	GTEx	Adipose Subcutaneous	CCDC9	0.18	0.16	lasso	5	0.16	5.0e-13	6.303	-6.3	3.5e-10	0.00	0.01	0.99	FALSE
3	GTEx	Adipose Visceral Omentum	CCDC9	0.19	0.10	enet	11	0.11	3.1e-06	6.308	-5.2	2.2e-07	-0.02	0.01	0.99	FALSE
4	GTEx	Adipose Visceral Omentum	DMWD	0.11	0.13	lasso	2	0.16	7.3e-09	-2.549	-7.0	1.9e-12	-0.85	0.04	0.96	FALSE
5	GTEx	Artery Aorta	DMWD	0.28	0.19	lasso	3	0.15	1.2e-08	10.594	-11.0	4.4e-28	-0.94	0.02	0.98	FALSE
6	GTEx	Artery Tibial	DMPK	0.12	0.03	lasso	4	0.03	3.1e-03	-4.369	-8.1	6.6e-16	-0.70	0.03	0.94	FALSE
7	GTEx	Artery Tibial	CCDC9	0.09	0.03	lasso	5	0.03	3.7e-03	6.266	-6.1	1.3e-09	-0.01	0.01	0.97	FALSE
8	GTEx	Artery Tibial	DMWD	0.22	0.17	lasso	8	0.16	6.8e-13	10.594	-10.5	1.1e-25	-0.97	0.01	0.99	FALSE
9	GTEx	Artery Tibial	AC074212.6	0.14	0.04	lasso	5	0.06	2.4e-05	11.124	-10.6	4.3e-26	-0.87	0.01	0.99	TRUE
10	GTEx	Brain Frontal Cortex BA9	QPCTL	0.42	0.08	enet	43	0.13	2.5e-04	-9.911	-10.1	4.8e-24	-0.47	0.06	0.56	FALSE
11	GTEx	Brain Frontal Cortex BA9	KPTN	0.26	0.01	lasso	4	0.00	4.1e-01	6.173	-6.0	2.4e-09	-0.02	0.01	0.80	FALSE
12	GTEx	Breast Mammary Tissue	DMWD	0.16	0.01	enet	21	0.02	2.0e-02	0.061	-5.3	1.4e-07	-0.36	0.03	0.50	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	CCDC9	0.32	0.22	enet	15	0.15	1.2e-05	6.257	-5.3	1.1e-07	0.00	0.01	0.99	FALSE
14	GTEx	Cells Transformed fibroblasts	DMPK	0.10	0.07	lasso	6	0.07	1.0e-05	-10.776	-8.7	3.7e-18	-0.43	0.37	0.59	FALSE
15	GTEx	Cells Transformed fibroblasts	CCDC9	0.16	0.13	lasso	3	0.14	2.0e-10	6.266	-6.1	1.1e-09	-0.02	0.01	0.99	FALSE
16	GTEx	Cells Transformed fibroblasts	SYMPK	0.18	0.14	lasso	6	0.13	7.5e-10	-10.774	11.8	3.1e-32	0.38	0.31	0.69	TRUE
17	GTEx	Cells Transformed fibroblasts	AC074212.6	0.07	0.05	enet	7	0.05	1.5e-04	-10.623	-8.9	5.9e-19	-0.44	0.30	0.45	FALSE
18	GTEx	Esophagus Mucosa	CCDC9	0.18	0.13	lasso	3	0.12	2.7e-08	6.257	-6.1	9.9e-10	0.01	0.01	0.99	FALSE
19	GTEx	Esophagus Mucosa	PVRL2	0.15	0.01	enet	10	0.02	1.7e-02	-7.349	5.6	2.0e-08	0.07	0.14	0.05	FALSE
20	GTEx	Esophagus Muscularis	CALM3	0.26	0.09	lasso	10	0.13	1.7e-08	-5.302	-5.7	1.1e-08	0.03	0.12	0.83	TRUE
21	GTEx	Esophagus Muscularis	AC074212.6	0.10	0.02	lasso	3	0.02	1.1e-02	-2.131	-8.4	4.5e-17	-0.37	0.05	0.38	FALSE
22	GTEx	Lung	DMPK	0.10	0.05	lasso	3	0.05	5.4e-05	-2.557	-5.3	1.1e-07	-0.77	0.03	0.96	FALSE
23	GTEx	Muscle Skeletal	DMWD	0.06	0.01	lasso	6	0.01	1.9e-02	10.594	-9.9	4.9e-23	-0.91	0.01	0.96	TRUE
24	GTEx	Nerve Tibial	CCDC9	0.28	0.17	enet	23	0.16	1.6e-11	6.257	-5.7	1.4e-08	0.01	0.01	0.99	FALSE
25	GTEx	Nerve Tibial	SYMPK	0.15	0.05	enet	21	0.08	1.8e-06	-9.911	8.5	1.7e-17	0.21	0.34	0.61	FALSE
26	GTEx	Nerve Tibial	DMWD	0.24	0.07	lasso	6	0.06	5.8e-05	10.594	-7.7	1.8e-14	-0.86	0.04	0.96	FALSE
27	GTEx	Skin Sun Exposed Lower leg	QPCTL	0.08	0.00	lasso	4	0.00	2.1e-01	8.503	-7.0	2.1e-12	-0.64	0.05	0.42	TRUE
28	GTEx	Spleen	PPP5C	0.33	0.44	lasso	1	0.43	1.8e-12	-6.024	6.0	1.7e-09	-0.06	0.96	0.00	FALSE
29	GTEx	Spleen	AC007193.9	0.49	0.07	lasso	5	0.20	7.8e-06	-6.024	5.9	4.3e-09	-0.06	0.00	0.98	FALSE
30	GTEx	Testis	SYMPK	0.22	0.21	lasso	1	0.20	2.9e-09	-10.492	-10.5	9.4e-26	-0.24	0.80	0.18	FALSE
31	GTEx	Thyroid	DMPK	0.13	0.11	lasso	2	0.12	1.3e-09	-2.582	-5.6	2.2e-08	-0.78	0.24	0.76	FALSE
32	GTEx	Thyroid	OPA3	0.13	0.00	enet	14	0.00	8.6e-01	2.139	7.3	2.0e-13	0.20	0.06	0.04	FALSE
33	GTEx	Thyroid	DMWD	0.11	0.12	lasso	3	0.11	6.7e-09	-2.603	-6.5	9.4e-11	-0.83	0.03	0.97	FALSE
34	GTEx	Thyroid	AC074212.6	0.08	0.10	lasso	2	0.09	1.8e-07	10.594	-10.6	3.1e-26	-0.95	0.02	0.97	FALSE
35	GTEx	Whole Blood	PVRL2	0.60	0.58	lasso	6	0.61	3.6e-71	6.555	7.0	3.4e-12	-0.02	1.00	0.00	FALSE
36	GTEx	Whole Blood	CTB-129P6.4	0.53	0.49	enet	26	0.50	2.3e-53	6.555	6.8	7.8e-12	-0.01	1.00	0.00	FALSE
37	METSIM	Adipose	PPP5C	0.23	0.18	lasso	8	0.18	3.8e-26	-6.024	6.5	9.9e-11	-0.05	1.00	0.00	TRUE
38	METSIM	Adipose	SYMPK	0.05	0.03	lasso	3	0.01	2.9e-03	-10.734	11.5	1.3e-30	0.32	0.42	0.56	FALSE
39	NTR	Blood	PVRL2	0.24	0.25	lasso	2	0.28	8.4e-92	5.846	7.0	2.5e-12	0.01	1.00	0.00	FALSE
40	YFS	Blood	PVRL2	0.40	0.33	lasso	2	0.36	9.5e-127	6.555	7.3	3.5e-13	-0.02	1.00	0.00	FALSE
41	YFS	Blood	SYMPK	0.07	0.01	bslmm	404	0.03	1.2e-10	-1.648	-5.3	1.3e-07	-0.02	0.64	0.36	FALSE
42	YFS	Blood	TOMM40	0.04	0.00	bslmm	371	0.01	2.6e-04	-6.430	6.3	2.7e-10	0.03	0.05	0.02	TRUE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	CKM	0.03	0.03	lasso	2	0.03	2.1e-06	-5.870	5.7	1.5e-08	-0.02	0.30	0.69	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	DMWD	0.01	0.00	blup	42	0.01	7.3e-03	-2.518	8.3	6.6e-17	0.83	0.01	0.81	TRUE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	FOXA3	0.03	0.02	blup	53	0.02	1.9e-04	11.224	-11.3	9.8e-30	-0.77	0.00	0.99	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	MARK4	0.03	0.01	lasso	2	0.03	2.0e-06	-5.079	6.7	2.9e-11	-0.03	0.42	0.21	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	PRKD2	0.04	0.02	blup	57	0.02	9.1e-06	-3.399	-6.0	2.4e-09	-0.11	0.04	0.10	TRUE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	SYMPK	0.03	0.02	lasso	2	0.02	3.5e-05	2.408	6.1	8.1e-10	0.15	0.11	0.08	FALSE
49	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CCDC9	0.09	0.00	enet	12	0.03	7.9e-03	3.489	-6.0	2.2e-09	0.00	0.01	0.77	FALSE
50	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CKM	0.13	0.00	blup	38	0.05	2.2e-03	3.836	7.9	3.7e-15	-0.05	0.01	0.40	TRUE
51	The Cancer Genome Atlas	Colon Adenocarcinoma	CKM	0.11	0.08	blup	38	0.07	1.1e-04	-4.264	7.2	7.9e-13	-0.03	0.02	0.94	FALSE
52	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	APOC2	0.13	0.22	lasso	4	0.21	8.6e-23	-5.633	5.6	2.1e-08	-0.14	1.00	0.00	FALSE
53	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SYMPK	0.07	0.04	lasso	2	0.03	9.4e-05	-10.774	10.8	4.8e-27	0.26	0.22	0.64	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	APOC1	0.05	0.03	enet	4	0.04	5.4e-05	-4.836	-5.1	2.9e-07	0.16	0.55	0.02	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	APOC2	0.19	0.27	lasso	3	0.26	1.9e-29	-5.633	5.6	2.1e-08	-0.13	1.00	0.00	FALSE
56	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CKM	0.06	0.03	blup	39	0.06	5.2e-07	-3.207	6.1	1.1e-09	0.00	0.15	0.84	FALSE
57	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	APOC2	0.27	0.25	enet	14	0.24	3.8e-14	-5.751	5.2	1.8e-07	-0.12	1.00	0.00	FALSE
58	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SIX5	0.05	0.05	lasso	8	0.03	7.6e-03	10.787	10.0	2.0e-23	0.98	0.00	0.96	TRUE
59	The Cancer Genome Atlas	Brain Lower Grade Glioma	CKM	0.05	0.04	blup	38	0.06	2.1e-07	-4.669	6.0	1.4e-09	0.03	0.14	0.85	FALSE
60	The Cancer Genome Atlas	Lung Adenocarcinoma	APOC2	0.24	0.24	enet	12	0.27	4.2e-31	-5.792	5.9	2.9e-09	-0.09	1.00	0.00	FALSE
61	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	APOC1	0.05	0.00	blup	47	0.01	4.3e-02	5.867	7.5	5.7e-14	0.07	0.01	0.06	TRUE
62	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	APOC2	0.16	0.27	lasso	4	0.27	4.0e-31	-5.633	5.6	2.8e-08	-0.13	1.00	0.00	FALSE
63	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	APOE	0.06	0.00	blup	49	0.01	4.5e-02	5.867	6.9	4.1e-12	0.08	0.02	0.09	FALSE
64	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CBLC	0.04	0.00	blup	37	0.02	2.1e-03	0.076	-5.3	1.1e-07	0.01	0.01	0.03	TRUE
65	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	APOE	0.12	0.05	blup	47	0.07	9.5e-06	-5.590	-6.8	1.5e-11	0.11	0.32	0.02	FALSE
66	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	APOC2	0.18	0.12	enet	14	0.13	5.2e-06	-5.633	5.6	1.7e-08	-0.10	0.66	0.03	FALSE
67	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	APOC4	0.13	0.14	lasso	1	0.14	1.8e-06	-5.590	-5.6	2.3e-08	0.13	0.86	0.01	FALSE
68	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCDC9	0.02	0.03	lasso	7	0.03	2.8e-04	6.266	-6.4	1.3e-10	0.00	0.01	0.93	TRUE
69	The Cancer Genome Atlas	Prostate Adenocarcinoma	CKM	0.03	0.01	blup	38	0.02	3.3e-03	-4.669	5.2	1.7e-07	0.04	0.05	0.19	FALSE
70	The Cancer Genome Atlas	Prostate Adenocarcinoma	FOXA3	0.04	0.01	blup	53	0.01	1.0e-02	-10.836	-9.8	1.4e-22	-0.29	0.02	0.09	FALSE
71	The Cancer Genome Atlas	Prostate Adenocarcinoma	SYMPK	0.09	0.06	lasso	3	0.05	8.7e-06	-10.492	10.8	2.0e-27	0.26	0.65	0.33	FALSE
72	The Cancer Genome Atlas	Rectum Adenocarcinoma	CCDC9	0.12	0.12	lasso	4	0.10	1.9e-03	6.266	-5.4	5.6e-08	-0.03	0.01	0.73	FALSE
73	The Cancer Genome Atlas	Soft Tissue Sarcoma	APOC4	0.13	0.10	blup	34	0.13	3.2e-08	-4.489	-6.6	4.5e-11	0.16	0.95	0.01	TRUE
74	The Cancer Genome Atlas	Stomach Adenocarcinoma	APOC2	0.08	0.07	enet	6	0.03	2.2e-03	-5.792	5.5	3.9e-08	-0.11	0.43	0.02	FALSE
75	The Cancer Genome Atlas	Testicular Germ Cell Tumors	APOC2	0.14	0.15	enet	5	0.16	3.5e-06	-5.633	5.7	1.2e-08	-0.13	0.43	0.03	FALSE
76	The Cancer Genome Atlas	Thyroid Carcinoma	APOC2	0.13	0.13	lasso	5	0.16	8.6e-16	-5.751	5.1	2.7e-07	-0.13	1.00	0.00	FALSE
77	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	APOC2	0.20	0.14	enet	10	0.14	7.9e-05	-5.019	7.3	3.8e-13	-0.10	0.15	0.05	FALSE