Best TWAS P=6.4e-10 · Best GWAS P=1.16e-11 conditioned to 0.000233
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | ORC4 | 0.07 | 0.02 | lasso | 1 | 0.00 | 2.5e-01 | 5.5 | 5.5 | 4.1e-08 | -0.53 | 0.12 | 0.38 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Female) | ORC4 | 0.12 | 0.00 | lasso | 4 | 0.00 | 2.3e-01 | -5.5 | 5.3 | 1.4e-07 | -0.86 | 0.04 | 0.25 | FALSE |
| 3 | GTEx | Heart Left Ventricle | ACVR2A | 0.07 | 0.08 | lasso | 1 | 0.07 | 9.3e-05 | 5.9 | 6.0 | 2.7e-09 | -0.58 | 0.32 | 0.58 | FALSE |
| 4 | GTEx | Muscle Skeletal | ACVR2A | 0.06 | 0.00 | enet | 29 | 0.00 | 2.2e-01 | 5.7 | 6.2 | 6.4e-10 | -0.64 | 0.10 | 0.60 | TRUE |
| 5 | GTEx | Testis | ORC4 | 0.24 | 0.24 | lasso | 16 | 0.24 | 8.9e-11 | 5.9 | 6.0 | 1.9e-09 | -0.57 | 0.47 | 0.53 | FALSE |
| 6 | YFS | Blood | ACVR2A | 0.08 | 0.09 | enet | 15 | 0.09 | 1.5e-27 | 6.3 | 5.6 | 2.2e-08 | -0.41 | 0.07 | 0.93 | FALSE |