TWAS hub - ORC4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.094	0.0300	4.0e-10	0.081	0.091	0.095	0.084	0.088	4.7e-10	3.3e-11	1.3e-11	2e-10	7.9e-11
2	GTEx	Breast Mammary Tissue	0.071	0.0450	9.1e-03	0.024	NA	-0.005	NA	0.002	2.0e-02	NA	7.7e-01	NA	2.5e-01
3	GTEx	Breast Mammary Tissue (Male)	0.245	0.1262	2.3e-02	-0.012	NA	-0.006	NA	0.005	8.1e-01	NA	4.5e-01	NA	2.4e-01
4	GTEx	Breast Mammary Tissue (Female)	0.120	0.0855	4.4e-02	-0.003	NA	0.001	NA	0.004	4.2e-01	NA	3.1e-01	NA	2.3e-01
5	GTEx	Testis	0.237	0.0660	3.4e-09	0.235	NA	0.214	NA	0.235	8.4e-11	NA	7.2e-10	NA	8.9e-11

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Neuroticism	5.9	14.2	62.9	-0.3	-1.6	-0.3	-7.9	-2.3
Diastolic blood pressure, automated reading	5.6	17.5	28.7	4.9	4.7	3.4	0.6	5.4
Supplements: Calcium	5.6	6.2	13.4	-3.7	-2.5	-2.2	-0.2	-2.6
Pulse wave Arterial Stiffness index	5.0	5.8	9.0	-2.2	-3.0	-0.3	-2.5	-3.0
Neuroticism (Nagel 2018)	4.9	11.5	51.6	-0.4	-1.5	-0.7	-7.2	-1.7
Neuroticism score	4.7	9.8	44.4	0.1	-1.3	-0.1	-6.7	-1.7
Falls in the last year	4.7	6.4	10.4	3.2	3.2	1.1	0.4	3.2
Loneliness, isolation	4.6	6.4	19.2	-1.5	-2.0	-1.6	-4.4	-2.0
Vitamin and mineral supplements	4.3	5.8	9.0	3.0	2.7	1.4	1.4	3.0
Medication: Cholesterol lowering	4.3	6.8	9.9	1.9	2.7	2.3	2.8	3.1
Friendships satisfaction	4.3	5.3	11.8	-1.8	-2.5	0.1	-3.4	-2.3
Medication: Bendroflumethiazide	4.3	6.5	10.0	3.2	3.0	1.9	0.3	3.1
Number of treatments/medications taken	4.1	7.3	10.2	3.0	3.2	2.9	0.1	3.0
Irritable Bowel Disease (IBD)	4.0	9.5	13.8	-3.1	-3.0	-2.2	-3.1	-3.7
Fasting Glucose	4.0	4.8	5.7	-2.2	-2.2	-2.1	-2.4	-2.1
Number of incorrect matches in round	4.0	6.6	12.3	2.4	3.3	-1.4	1.4	3.5
Heart disease (mother)	4.0	4.9	8.8	2.4	2.8	1.1	0.9	3.0
Mouth/teeth dental problems	3.9	5.9	9.5	3.0	3.1	0.3	2.1	2.5
Ulcerative Colitis	3.8	5.5	8.3	-2.9	-2.3	-1.8	-1.9	-2.7
Sensitivity / hurt feelings	3.8	6.5	26.2	-0.6	-1.2	-0.8	-5.1	-2.0
Pulse wave peak to peak time	3.8	4.5	7.0	1.7	2.5	0.1	2.6	2.6
Crohns Disease (2017)	3.6	8.0	10.8	-2.8	-2.7	-3.1	-2.1	-3.3
Ulcerative Colitis (UC)	3.5	6.5	8.8	-2.6	-2.5	-1.5	-3.0	-2.9
Pulse wave reflection index	3.5	4.3	7.5	-1.8	-2.4	-1.2	-1.9	-2.7
Shortness of breath walking on level ground	3.5	4.2	6.7	2.6	1.9	2.2	-0.9	2.2
Depressed Affect (Nagel 2018)	3.4	7.1	27.5	-1.0	-1.9	-0.4	-5.2	-1.8
Blood Eosinophil Count	3.4	26.3	36.1	4.9	5.5	3.7	5.3	6.0
Gout (self-reported)	3.4	4.7	7.7	2.2	2.8	0.9	2.1	2.3
Worry (Nagel 2018)	3.2	6.7	30.9	0.3	-0.8	-1.2	-5.6	-0.7
Miserableness	3.2	5.6	21.7	-0.7	-1.5	0.4	-4.7	-1.7
Fed-up feelings	3.1	5.6	21.1	-0.5	-1.7	-0.2	-4.6	-2.0
Depression (Nagel 2018)	2.9	4.4	10.4	-1.5	-1.9	0.6	-3.2	-2.3
Tinnitus: Yes, but not now, but have in the past	2.8	3.0	5.4	1.7	1.9	2.3	-0.2	1.7
Exposure to tobacco smoke at home	2.8	3.2	5.8	1.7	1.6	2.4	1.1	1.9
Tense / ‘highly strung’	2.8	4.6	21.2	0.5	-0.7	-0.9	-4.6	-0.8
Medication for pain relief, constipation, heartburn	2.8	4.8	8.8	-1.9	-3.0	-2.0	-0.4	-2.8
Family relationship satisfaction	2.8	3.4	7.5	-1.1	-1.9	0.5	-2.7	-2.0
Severe depression (siblings)	2.7	3.0	4.9	1.7	2.2	0.8	1.7	1.9
Forced expiratory volume in 1-second (FEV1), predicted	2.6	5.5	9.2	-3.0	-2.4	-2.2	-0.7	-2.7
Frequency of unenthusiasm / disinterest in last 2 weeks	2.5	3.3	6.9	-1.1	-1.7	0.5	-2.6	-2.3
Worrier / anxious feelings	2.5	4.7	18.5	1.8	1.0	0.0	-4.3	0.9
Medication: Aspirin	2.5	3.2	5.2	1.6	2.2	1.5	1.2	2.3
Irritability	2.5	4.2	19.4	0.7	0.2	1.0	-4.4	-0.2
Illnesses of mother	2.4	3.0	5.4	-2.3	-1.9	-1.6	-0.4	-1.8
Medication: Aspirin	2.4	3.2	5.8	1.6	2.2	1.0	1.4	2.4
Average weekly red wine intake	2.4	3.5	9.0	1.1	1.7	0.6	3.0	2.0
Mineral and other dietary supplements	2.3	3.1	5.8	2.4	2.1	0.5	0.5	2.2
Neuroticism (2016)	2.2	3.1	13.5	-0.4	-0.6	-0.6	-3.7	-1.2
Multivitamins +/- minerals	2.2	2.8	4.2	-2.0	-1.9	-1.2	-0.9	-2.1
Supplements: Glucosamine	2.2	2.9	6.1	-2.5	-2.0	-0.6	1.2	-1.6
Nervous feelings	2.2	4.0	18.1	0.5	-1.1	-0.0	-4.3	-0.7
Schizophrenia vs Biploar Disorder	2.1	2.8	5.6	1.4	2.4	0.7	1.2	2.1
Breastfed as a baby	2.1	2.6	4.5	1.3	2.1	0.9	1.4	2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	4.5	2.1	2.1	-0.9	-0.6	1.8
Financial situation satisfaction	2.1	2.6	7.1	1.4	1.4	2.7	-0.7	1.1
Cardiovascular Disease	2.0	6.7	10.1	3.1	3.2	2.0	-0.4	3.1
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	11.0	-0.6	-1.1	1.1	-3.3	-1.3
Ever depressed for a whole week	2.0	2.5	6.8	1.3	0.8	2.6	1.1	1.5
Major Depression (MDD)	1.9	2.4	5.1	2.3	1.6	0.4	-0.2	1.9
HbA1C	1.9	2.2	3.3	1.8	1.7	1.5	-0.4	1.5
Allergy	1.9	4.3	7.6	-2.0	-2.2	-2.8	-0.5	-2.2
Chronic bronchitis/emphysema (mother)	1.9	2.2	4.2	1.8	2.0	-0.8	0.5	1.7
Long-standing illness, disability or infirmity	1.9	3.0	5.3	2.3	2.1	1.0	-0.5	1.9
Vascular/heart problems diagnosed by doctor	1.9	5.1	9.0	-2.6	-3.0	-1.3	0.7	-2.8
Forced vital capacity (FVC)	1.8	6.8	11.4	-3.2	-3.3	0.7	0.9	-3.4
Mouth/teeth dental problems: Dentures	1.8	3.0	4.8	-1.6	-2.2	-0.5	-2.1	-1.7
Medication: Gliclazide	1.8	2.1	5.2	0.6	0.8	2.3	1.7	1.1
Risk taking	1.8	2.6	4.4	-1.8	-2.1	-1.9	-0.4	-1.2
Chronotype (morning person)	1.7	4.0	6.6	2.6	2.5	0.7	-0.1	2.6
Pack years adult smoking proportion	1.7	2.6	12.0	-0.2	0.0	0.7	-3.5	-0.7
Crohns Disease (2012)	1.6	2.5	6.1	-2.5	-1.1	-1.6	-0.5	-1.6
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	3.8	1.9	1.2	1.3	0.2	1.6
Illnesses of siblings	1.6	2.2	4.1	-1.6	-1.4	-2.0	-0.6	-1.4
Suffer from ‘nerves’	1.6	2.4	8.5	-0.4	-0.9	-1.5	-2.9	-0.8
Guilty feelings	1.6	2.4	9.5	1.1	0.5	0.9	-3.1	0.2
Taking other prescription medications	1.5	2.4	4.6	1.9	2.1	0.6	-0.4	1.8
Medication: Simvastatin	1.5	2.2	3.9	0.7	1.8	1.7	0.9	2.0
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.5	9.4	0.7	-0.6	1.0	-3.1	-0.9
Hair/balding pattern: Pattern 3	1.5	2.2	4.3	2.1	1.9	1.1	0.1	1.5
Medication for cholesterol, blood pressure or diabetes	1.5	2.6	5.3	-0.9	-2.0	-1.5	-0.8	-2.3
Hypothyroidism/myxoedema (self-reported)	1.5	3.0	4.5	1.9	2.1	-0.8	1.6	1.9
Birth weight	1.5	3.3	5.9	-2.4	-2.2	-1.9	0.5	-1.4
Hypertension (Self-reported)	1.5	4.1	5.6	2.4	2.4	1.7	-1.1	2.3
Bipolar Disorder (2011)	1.4	1.3	2.7	-0.9	-1.3	-1.6	0.5	-1.1
Depression (self-reported)	1.4	1.6	2.8	1.5	1.3	-0.1	1.7	1.2
Prospective memory result	1.4	1.7	2.9	1.4	1.7	-0.7	-1.2	1.3
Medication: Paracetamol	1.4	2.4	4.8	1.5	2.2	1.0	-0.1	2.0
Exposure to tobacco smoke outside home	1.4	1.8	4.4	2.1	1.6	-0.0	-0.2	1.4
Worry too long after embarrassment	1.4	2.4	9.0	0.8	-0.2	1.3	-3.0	-0.6
Qualifications: College or University degree	1.4	4.5	7.1	-2.7	-2.6	-1.2	1.4	-2.3
Mouth/teeth dental problems: Loose teeth	1.4	1.7	6.4	-0.9	-0.6	-0.8	-2.5	-0.5
Medication: Allopurinol	1.4	1.9	3.2	1.4	1.5	-0.3	1.8	1.3
Hayfever, allergic rhinitis or eczema	1.3	2.8	4.2	2.0	1.5	2.1	0.5	1.8
Standing height	1.3	12.4	23.9	-4.9	-4.5	0.1	0.8	-4.1
Medication: Amlodipine	1.3	1.8	3.8	2.0	1.4	1.2	0.4	1.3
Comparative height size at age 10	1.3	7.1	13.0	-3.6	-3.3	-1.0	-0.4	-3.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	3.7	-0.5	-0.8	1.4	-1.9	-1.2
Eye problems/disorders: Cataract	1.3	1.6	6.9	0.5	0.4	2.6	-0.5	-0.5
Osteoporosis (self-reported)	1.3	1.6	5.6	-1.1	-0.9	-2.4	0.1	-0.4
Unable to work because of sickness or disability	1.3	1.7	6.0	-0.2	-0.4	-1.0	-2.4	-1.0
Pack years of smoking	1.3	1.9	8.7	-0.1	0.4	0.8	-2.9	-0.2
Alzheimer’s Disease (in mother)	1.2	1.4	5.9	0.4	0.6	-0.3	2.4	0.7
Current tobacco smoking	1.2	1.9	5.4	-1.1	-1.2	-0.7	-2.3	-1.1
High blood pressure	1.2	3.3	5.7	2.1	2.4	1.0	-0.7	2.2
Medication: Atenolol	1.2	1.5	3.2	0.9	1.8	1.2	-0.1	1.4
Hearing difficulty/problems with background noise	1.2	1.9	2.4	1.3	1.6	1.4	1.1	1.5
Pulse rate	1.2	2.1	5.0	1.1	1.2	0.7	-2.2	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	2.7	1.6	1.6	0.7	0.9	1.6
Smoking status: Current	1.2	1.9	4.6	-1.1	-1.1	-1.1	-2.2	-1.1
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	2.5	1.1	0.9	1.2	-1.6	1.1
Reaction Time	1.1	2.1	4.1	1.3	2.0	1.3	0.7	1.5
Blood Red Count	1.1	10.3	19.1	3.6	3.7	0.5	2.2	4.4
Heel T-Score	1.1	8.9	18.6	3.3	2.8	4.3	-0.5	2.5
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.9	-0.5	-0.8	1.5	-2.0	-0.8
Diabetes (father)	1.1	1.4	2.2	-1.5	-1.5	-0.7	-0.5	-1.4
Heart attack	1.1	1.4	2.1	0.9	1.4	0.7	1.5	1.2
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	2.3	-1.2	-1.2	-0.6	0.8	-1.5
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.1	1.2	1.0	1.4	0.8	1.0
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	1.9	-1.2	-1.4	1.4	-1.0	-1.0
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.9	0.6	0.8	1.4	1.7	1.1
Eye problems/disorders: None of the above	1.1	1.3	4.5	-0.7	-1.1	-2.1	-0.6	-0.2
Medication: Blood pressure	1.1	2.0	4.1	1.0	1.9	1.0	-0.5	2.0
Mood swings	1.1	2.0	7.8	1.3	0.3	0.1	-2.8	0.5
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	2.9	-1.7	-1.5	-1.0	-0.7	-1.4
Back pain experienced in last month	1.1	1.6	2.3	1.5	1.5	1.1	-0.4	1.5
Illnesses of father: High blood pressure	1.1	1.3	2.5	1.5	1.4	0.1	0.1	1.6
Heart attack/myocardial infarction (self-reported)	1.1	1.4	2.3	0.9	1.4	0.2	1.5	1.3
Alzheimer’s Disease (including proxy)	1.0	1.5	2.2	1.2	1.1	-0.4	1.5	1.5
Lupus	1.0	1.5	5.6	-0.1	0.2	-2.4	-1.2	-0.4
Blood White Count	1.0	7.3	10.7	2.6	3.0	3.3	0.8	3.1
Hypothyroidism (self reported)	1.0	2.2	3.2	1.7	1.8	-1.1	1.4	1.5
Lung FEV1/FVC ratio	1.0	5.1	8.6	2.9	2.9	0.7	0.9	2.7
Relative age of first facial hair	1.0	2.0	8.4	1.1	0.5	2.9	-0.0	0.5
Serious illness, injury or assault to yourself	1.0	1.2	2.3	0.9	1.1	0.3	1.5	1.3
Glaucoma (self-reported)	1.0	1.2	2.5	-1.1	-1.3	0.7	-0.1	-1.6
Pulse rate, automated reading	1.0	3.2	14.4	-0.3	-0.8	-0.9	-3.8	-0.5
Commuting to job workplace: Public transport	1.0	1.1	1.8	1.3	1.1	1.1	0.2	1.2
Medication: Paracetamol	1.0	1.6	3.8	1.2	2.0	0.8	-0.0	1.4
Myopia	1.0	1.5	2.8	-0.1	-1.7	-0.5	-1.4	-1.6
Basal cell carcinoma (self-reported)	1.0	1.2	2.6	-1.6	-1.0	-1.3	-0.1	-0.8
Ovarian Cancer	0.9	1.2	2.2	1.5	0.8	1.3	0.8	0.8
Age at First Birth	0.9	1.3	2.6	-1.3	-1.0	-1.6	0.8	-0.8
Systolic Blood Pressure	0.9	4.6	6.7	2.6	1.9	1.9	-2.6	1.6
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	3.0	0.2	0.1	1.7	-1.4	0.3
Medication: Levothyroxine sodium	0.9	1.5	3.4	0.7	1.1	-0.9	1.8	1.1
Forced expiratory volume in 1-second (FEV1)	0.9	3.2	6.1	-2.0	-2.3	0.7	0.6	-2.5
Forced vital capacity (FVC), Best measure	0.9	3.4	5.9	-2.3	-2.3	0.8	0.1	-2.4
Emphysema/chronic bronchitis	0.9	1.0	2.7	0.6	0.9	1.6	-0.8	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	1.9	1.4	0.9	-0.9	-1.1	0.6
Medication: Blood pressure	0.9	1.8	3.2	1.7	1.8	1.0	-0.2	1.3
Commuting to job workplace: Cycle	0.9	1.1	2.6	0.5	0.9	1.6	1.4	0.2
Coronary Artery Disease (CAD)	0.8	0.9	1.9	1.0	1.1	0.4	0.6	1.4
HDL Cholesterol	0.8	1.3	6.1	-0.1	-0.3	-0.5	2.5	0.0
Medication for hormone replacement therapy	0.8	0.9	2.6	0.5	0.5	-1.1	-1.6	0.3
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	4.3	0.4	0.2	0.0	-2.1	0.4
Had other major operations	0.8	1.0	3.6	0.0	-0.5	1.9	0.6	-0.9
Arm fat percentage (right)	0.8	3.3	6.9	1.4	1.9	2.6	1.3	1.6
Wheeze or whistling in the chest in last year	0.8	1.5	2.8	1.0	1.4	1.7	0.2	1.3
Health satisfaction	0.8	1.1	3.4	0.3	-0.6	1.9	-1.1	-0.6
Neck or shoulder pain in last month	0.8	1.2	2.3	1.3	1.0	1.5	0.2	1.0
Migraine (self-reported)	0.8	1.0	2.2	1.5	1.4	0.1	0.3	0.9
Medication: Omeprazole	0.8	0.9	4.0	0.1	-0.2	0.8	-2.0	-0.0
Mean time to correctly identify matches	0.8	1.5	2.6	0.5	1.6	1.1	1.1	1.5
Number of full sisters	0.8	1.0	2.0	0.9	1.4	-0.7	0.5	1.2
Age at last live birth	0.8	1.2	2.0	1.3	0.8	0.8	1.0	1.4
Medication for cholesterol	0.8	1.2	2.4	-1.0	-1.5	-1.0	0.7	-1.0
Alzheimer’s Disease (in father)	0.7	0.7	2.5	0.7	-0.3	-1.6	0.6	0.5
Primary Biliary Cirrhosis	0.7	1.0	4.6	-0.0	0.3	0.4	2.1	0.2
Rheumatoid Arthritis	0.7	1.0	1.6	-1.0	-1.2	-0.0	-0.9	-1.2
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.4	0.5	0.6	-0.3	-1.0	1.6
Ever had hysterectomy (womb removed)	0.7	0.7	1.3	1.1	0.9	0.6	0.2	1.1
Angina	0.7	1.0	2.2	0.3	1.2	1.0	-1.5	0.4
Supplements: Zinc	0.7	0.7	2.2	0.6	0.4	1.5	-0.9	0.2
Trunk fat percentage	0.7	2.9	6.1	1.3	1.6	2.5	1.4	1.6
Sitting height	0.7	5.1	9.8	-2.6	-3.1	0.8	0.1	-2.9
Financial difficulties in last 2 years	0.7	1.0	1.7	0.8	0.6	1.3	1.3	0.6
Trunk fat-free mass	0.7	4.2	7.7	-2.8	-2.6	0.2	0.2	-2.5
Happiness	0.7	0.8	3.1	-0.4	-0.5	0.3	-1.8	-0.7
Trunk predicted mass	0.7	4.2	7.7	-2.8	-2.6	0.1	0.1	-2.6
Peak expiratory flow (PEF)	0.7	1.6	6.0	0.8	0.4	2.5	0.9	0.5
High blood pressure (siblings)	0.7	1.0	2.2	1.0	0.9	1.5	-0.6	0.7
Leg fat percentage (right)	0.7	2.5	4.0	1.9	1.8	1.2	-0.2	2.0
Leg fat-free mass (right)	0.7	3.5	6.4	-2.5	-2.3	0.2	0.7	-2.4
Arm fat percentage (left)	0.7	2.7	6.0	1.2	1.7	2.5	1.0	1.4
Ever had bowel cancer screening	0.7	0.9	2.0	-1.4	-1.0	0.4	-0.6	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.5	1.2	1.0	-0.2	0.4	1.0
Qualifications: nursing, teaching	0.7	1.0	2.3	1.3	0.6	0.0	1.5	0.9
Leg predicted mass (right)	0.7	3.5	6.2	-2.5	-2.3	0.2	0.7	-2.4
Number of self-reported non-cancer illnesses	0.7	1.3	2.3	0.9	1.5	-0.6	-1.3	1.2
Ever taken oral contraceptive pill	0.7	0.7	2.4	0.4	0.3	1.5	-0.7	0.7
Leg fat percentage (left)	0.7	2.4	4.1	1.9	1.9	0.8	0.0	2.0
Breast Cancer	0.6	1.5	4.5	0.9	0.6	0.9	2.1	0.9
Body Mass Index (BMI) (2010)	0.6	0.9	1.6	0.8	1.3	0.6	0.7	1.1
Average weekly spirits intake	0.6	0.7	1.3	-1.1	-0.7	0.5	0.9	-0.8
Systolic blood pressure, automated reading	0.6	1.7	2.9	1.4	0.8	1.7	-1.3	1.2
Stomach or abdominal pain in last month	0.6	0.8	3.3	0.1	-0.0	0.6	-1.8	-0.5
Alcohol usually taken with meals	0.6	0.9	2.8	0.6	0.6	0.4	1.7	1.0
Pain all over the body in last month	0.6	0.7	2.6	-0.5	-0.1	-1.6	-0.4	-0.6
Body fat percentage	0.6	2.5	4.2	1.3	1.7	2.0	1.1	1.6
Medication: Seretide 50 evohaler	0.6	0.7	2.9	0.5	0.0	0.3	1.7	0.2
Overall health rating	0.6	1.3	4.8	-0.7	-0.4	-0.4	-2.2	-1.0
Illnesses of father: Heart disease	0.6	0.8	1.2	0.6	0.7	-1.1	0.8	1.1
Smoking status: Previous	0.6	0.9	2.0	0.3	0.9	1.4	0.7	1.0
Whole body fat-free mass	0.6	3.7	6.6	-2.6	-2.4	0.2	0.3	-2.4
Whole body water mass	0.6	3.7	6.8	-2.6	-2.4	0.2	0.3	-2.4
Ever smoked	0.6	1.0	2.4	-1.4	-0.5	0.6	-1.6	-0.3
Number of operations (self-reported)	0.6	0.9	3.6	-0.8	0.1	1.9	-0.3	-0.4
Alcohol drinker status: Previous	0.6	0.7	1.3	0.9	0.6	0.8	-1.1	0.5
Bipolar Disorder (2018)	0.5	0.8	1.4	0.5	-1.1	-1.2	0.7	-0.7
Schizophrenia (2018)	0.5	1.1	2.1	0.6	1.2	-0.3	-1.5	1.2
Height	0.5	9.8	19.9	-4.5	-3.7	0.7	1.9	-3.4
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.8	0.3	-0.6	-1.3	-0.8	-0.3
Diabetes (mother)	0.5	0.7	0.9	0.9	1.0	-0.5	-0.8	0.9
Leg fat-free mass (left)	0.5	2.6	4.5	-2.1	-1.9	0.6	0.6	-2.0
Relative age voice broke	0.5	0.7	2.7	0.7	0.4	1.6	0.3	0.1
Leg predicted mass (left)	0.5	2.6	4.5	-2.1	-1.9	0.7	0.5	-2.0
Qualifications: None of the above	0.5	1.0	3.0	0.8	0.5	0.5	-1.7	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.0	1.0	0.4	0.0	1.4	0.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.4	-1.2	-0.6	-0.7	1.0	-0.6
Arm fat-free mass (right)	0.5	2.3	4.0	-2.0	-2.0	-0.3	-0.2	-1.9
Angina (self-reported)	0.5	0.7	1.8	0.1	1.0	0.7	-1.4	0.4
Medication: Ibuprofen	0.5	0.6	2.1	0.5	-0.5	-0.1	1.4	-0.6
Arm predicted mass (right)	0.5	2.4	4.2	-2.0	-2.0	-0.4	-0.1	-1.9
Alcohol intake frequency.	0.5	1.1	2.3	-0.7	-0.6	-1.1	-1.5	-1.1
Commuting to job workplace: Walk	0.5	0.6	1.3	-0.7	-1.2	-0.4	0.6	-0.7
Breast cancer (self-reported)	0.5	0.6	1.1	-0.6	-0.9	0.9	-0.4	-1.0
Alcohol drinker status: Never	0.5	0.6	2.3	0.2	0.6	-1.5	-0.7	0.1
Basal metabolic rate	0.5	2.8	5.0	-2.2	-2.0	0.6	0.5	-2.0
Arm fat-free mass (left)	0.5	2.3	4.9	-2.2	-1.9	-0.2	0.4	-1.7
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.8	-0.5	-0.9	1.7	1.3	-0.1
Mean Putamen Volume	0.4	0.4	1.8	1.4	0.3	0.4	0.3	0.2
Triglycerides	0.4	0.6	2.4	0.4	-0.4	-0.3	-1.6	-0.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.0	-0.4	0.8	-1.0	0.2	0.8
High blood pressure (mother)	0.4	0.6	2.1	0.1	-0.2	0.8	-1.4	-0.3
Body mass index (BMI)	0.4	1.8	2.6	1.3	1.6	1.6	0.5	1.4
Trunk fat mass	0.4	1.6	5.1	0.5	0.7	2.3	1.3	0.8
Arm fat mass (right)	0.4	1.7	4.9	0.6	1.0	2.2	1.3	0.8
Hair/balding pattern: Pattern 4	0.4	0.9	2.0	1.1	0.6	0.7	1.4	0.5
Loud music exposure frequency	0.4	0.4	1.5	-0.2	-0.5	-0.2	-1.2	-0.5
Had major operations	0.4	0.5	0.8	-0.8	0.5	0.2	0.8	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.9	-0.8	-0.4	-0.9	-0.6	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	4.3	-0.0	0.4	-0.3	2.1	0.2
Arm fat mass (left)	0.4	1.5	4.8	0.4	0.9	2.2	1.2	0.7
Average weekly champagne plus white wine intake	0.4	0.5	1.5	0.2	0.4	-1.2	0.9	0.3
Wears glasses or contact lenses	0.4	0.5	0.8	0.3	0.1	0.9	0.8	0.9
Hearing aid user	0.4	0.5	1.3	0.1	0.8	-0.0	0.8	1.1
Eye problems/disorders: Glaucoma	0.4	0.5	1.9	-0.1	0.2	1.4	0.8	0.1
Medication: Lisinopril	0.4	0.5	1.1	0.6	0.8	-0.0	0.7	1.1
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.5	-0.4	-0.7	0.1	-1.2	-0.1
Heart disease (siblings)	0.4	0.5	1.7	0.2	0.2	1.3	0.8	0.2
Arm predicted mass (left)	0.4	2.2	4.2	-2.0	-1.9	-0.3	0.4	-1.8
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.2	-0.1	-1.1	1.5	0.2	-0.7
Prostate Cancer	0.3	0.4	1.5	-1.2	-0.2	0.5	0.3	-0.2
Waist Hip Ratio (WHR)	0.3	1.5	3.4	1.9	1.0	1.2	-0.2	1.2
Respiratory disease	0.3	0.8	2.6	-0.4	-0.2	1.6	-1.0	-0.3
Hand grip strength (left)	0.3	0.8	3.2	-1.8	-0.5	0.2	0.4	-0.3
Hearing difficulty/problems: Yes	0.3	0.5	1.1	-0.5	-0.6	-1.0	-0.9	-0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.5	0.5	0.3	-0.2	-1.2	0.1
Hand grip strength (right)	0.3	0.9	2.4	-1.0	-0.5	0.9	1.5	0.4
Townsend deprivation index at recruitment	0.3	0.5	1.0	0.5	0.9	0.4	-0.2	1.0
Average weekly fortified wine intake	0.3	0.4	0.9	0.5	0.3	1.0	-0.7	0.3
Waist circumference	0.3	1.0	4.2	0.3	0.5	2.1	0.6	0.5
Past tobacco smoking	0.3	0.6	1.1	0.0	-0.8	-1.0	0.6	-0.9
Medication: Ramipril	0.3	0.4	1.4	-0.4	0.7	1.2	0.1	0.3
Fluid intelligence score	0.3	0.6	1.6	-0.3	-1.3	0.2	-0.4	-1.1
Impedance of arm (right)	0.3	1.3	3.9	0.5	0.7	2.0	1.2	0.5
Alcohol intake versus 10 years previously	0.3	0.4	0.7	-0.8	-0.7	0.5	0.2	-0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.5	-0.7	-1.2	-0.1	-0.0	-1.1
Medication: Lansoprazole	0.3	0.3	0.5	0.2	0.6	0.7	-0.6	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	1.6	-0.8	-1.0	1.0	-0.0	-1.3
Birth weight of first child	0.3	0.6	1.1	-0.8	-0.2	1.0	1.0	-0.3
Headache pain in last month	0.3	0.6	1.4	1.2	0.7	0.2	-0.7	0.6
Comparative body size at age 10	0.3	0.8	1.3	-1.1	-1.1	0.8	0.2	-0.9
Number of full brothers	0.3	0.4	0.9	0.9	0.9	0.2	0.0	0.4
Number of children fathered	0.3	0.4	0.7	-0.7	-0.8	-0.7	0.1	-0.4
Whole body fat mass	0.3	1.5	4.2	0.6	0.8	2.1	1.1	0.8
Illnesses of father: None of the above (group 1)	0.3	0.4	0.6	0.6	0.7	0.8	-0.4	0.4
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.5	0.2	-0.2	0.4	-1.2	-0.1
High cholesterol (Self-reported)	0.3	0.6	1.1	0.7	0.8	0.3	0.7	1.1
Medication: Atorvastatin	0.3	0.4	1.3	0.2	0.3	-0.4	1.1	0.4
Average weekly beer plus cider intake	0.3	0.5	1.4	-0.2	-0.6	-1.2	-0.6	-0.5
Pain experienced in last month	0.3	0.5	1.1	-1.0	-0.3	-1.0	0.4	-0.4
Bipolar Disorder or Schizophrenia	0.2	0.5	0.9	0.9	0.3	-1.0	-0.7	0.5
Schizophrenia (2014)	0.2	0.5	0.6	0.3	0.8	-0.7	-0.8	0.7
BMI	0.2	1.2	6.0	-0.0	0.3	2.4	0.3	0.1
Smoking Status	0.2	0.4	0.7	-0.3	0.7	0.8	-0.6	0.8
Maternal smoking around birth	0.2	0.2	0.6	0.2	0.4	-0.7	0.5	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.6	2.2	0.6	0.4	1.5	0.1	0.1
Qualifications: CSEs or equivalent	0.2	0.3	1.1	-0.1	-0.7	-0.2	-0.1	-1.0
Chronic bronchitis/emphysema (father)	0.2	0.3	0.5	0.1	0.7	0.7	0.1	0.6
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	-0.0	0.4	0.7	0.8	0.6
Had menopause	0.2	0.2	0.5	-0.7	-0.3	-0.6	-0.4	-0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.5	0.6	0.2	0.5	0.3	0.7
Weight	0.2	0.8	1.9	-1.0	-0.6	1.4	0.8	-0.6
Hip circumference	0.2	0.8	1.4	-1.1	-0.7	1.2	0.7	-0.7
Number of live births	0.2	0.2	0.7	0.0	-0.8	0.1	-0.6	-0.2
Lung cancer (father)	0.2	0.3	1.1	-0.2	0.4	0.1	0.3	1.1
Impedance of arm (left)	0.2	0.8	3.1	-0.1	0.1	1.8	0.8	-0.0
Length of working week for main job	0.2	0.3	1.0	0.3	-0.2	-0.4	1.0	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.8	0.1	-0.9	-0.3	0.4	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.7	-0.3	0.2	-0.2	0.8	0.6
Leg fat mass (right)	0.2	0.8	1.6	0.9	0.9	1.3	0.4	0.9
Chest pain or discomfort	0.2	0.3	0.6	-0.5	-0.4	0.5	-0.8	-0.3
Leg pain on walking	0.2	0.2	0.8	-0.5	-0.2	-0.1	-0.9	-0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.6	0.1	0.7	-0.5	0.4	0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	-0.4	-0.1	-0.6	-0.9	-0.3
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.9	1.0	-0.2	-0.3	-0.6	-0.2
Osteoarthritis (self-reported)	0.2	0.2	0.3	-0.6	-0.5	0.5	-0.2	-0.2
Mother’s age at death	0.2	0.2	0.8	-0.3	-0.3	0.9	-0.2	-0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	-0.5	-0.3	0.4	-0.0	-0.7
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.5	-0.6	-0.5	0.1	0.6	-0.7
Cholesterol lowering medication	0.2	0.3	0.6	0.6	0.8	0.6	-0.2	0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.1	-1.1	-0.0	0.4	0.2	-0.2
Leg fat mass (left)	0.2	0.8	1.0	0.9	0.9	1.0	0.6	0.9
LDL Cholesterol	0.1	0.2	0.7	-0.1	-0.5	0.8	-0.2	-0.3
Allergy or Eczema	0.1	0.3	0.9	0.5	0.2	0.7	0.9	0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	0.1	-0.4	-0.0	-0.7	0.1
Lung FVC	0.1	0.7	2.0	-0.1	-0.6	1.4	0.8	-0.5
Tanning	0.1	1.1	3.0	-1.2	-0.2	-1.7	1.0	-0.1
Medication: Co-codamol	0.1	0.1	0.2	0.5	-0.0	0.3	-0.1	0.3
Medication: Metformin	0.1	0.1	0.2	0.4	-0.3	-0.0	-0.3	-0.1
Impedance of leg (right)	0.1	0.4	0.8	0.9	0.4	-0.3	-0.8	0.7
Age when periods started (menarche)	0.1	0.3	0.7	-0.2	-0.4	-0.3	-0.9	-0.6
Impedance of leg (left)	0.1	0.5	0.9	0.9	0.3	-1.0	-0.5	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	0.3	-0.1	0.6	-0.3	-0.5
Diabetes (self-reported)	0.1	0.2	0.3	0.5	-0.3	0.6	-0.3	0.1
Father’s age at death	0.1	0.2	0.5	-0.7	-0.6	0.1	0.2	-0.2
Noisy workplace	0.1	0.1	0.4	0.1	-0.2	-0.6	0.3	0.3
Asthma	0.1	0.3	1.1	0.1	0.1	1.1	-0.5	-0.0
Blood clot in the leg (DVT)	0.1	0.2	0.6	-0.8	0.1	0.4	0.1	-0.1
Age at first live birth	0.1	0.2	0.4	0.6	0.1	0.4	0.3	0.6
Supplements: Vitamin C	0.1	0.1	0.1	-0.3	0.3	-0.3	0.3	0.3
Knee pain experienced in last month	0.1	0.1	0.3	-0.5	-0.2	0.1	0.4	-0.5
Diabetes diagnosed by doctor	0.1	0.1	0.2	0.5	-0.5	0.2	-0.4	-0.2
Asthma (self-reported)	0.1	0.2	0.7	0.2	0.2	0.9	-0.5	-0.1
Fractured/broken bones in last 5 years	0.1	0.1	0.3	0.4	-0.3	-0.5	-0.1	0.1
Age started oral contraceptive pill	0.1	0.1	0.3	-0.5	-0.2	0.3	-0.4	0.0
Impedance of whole body	0.1	0.3	0.4	0.5	0.5	0.5	0.6	0.5
Blood Platelet Count	0.0	0.5	1.3	0.0	-0.5	1.1	0.8	-0.6
Hair Pigment	0.0	0.6	1.2	1.1	0.4	-0.9	-0.6	0.6
Time employed in main current job	0.0	0.1	0.1	0.1	-0.1	-0.2	-0.3	0.3
Illnesses of siblings: Diabetes	0.0	0.1	0.1	0.1	-0.3	0.3	-0.1	-0.3

Hub : Genes

ORC4

Models

Trait associations