TWAS hub - ACVR2A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Atrial Appendage	0.1310	0.0570	0.00034	0.040	NA	0.027	NA	0.041	6.6e-03	NA	2.2e-02	NA	6.3e-03
2	GTEx	Heart Left Ventricle	0.0737	0.0350	0.00260	0.079	NA	0.069	NA	0.074	5.2e-05	NA	1.6e-04	NA	9.3e-05
3	GTEx	Muscle Skeletal	0.0552	0.0315	0.00260	0.001	NA	0.001	NA	-0.001	2.3e-01	NA	2.2e-01	NA	3.7e-01
4	GTEx	Pancreas	0.0800	0.0420	0.00820	-0.006	NA	0.009	NA	-0.006	7.2e-01	NA	1.2e-01	NA	7.9e-01
5	GTEx	Whole Blood	0.0550	0.0240	0.00087	0.002	NA	0.006	NA	0.014	1.9e-01	NA	8.1e-02	NA	1.6e-02
6	YFS	Blood	0.0789	0.0225	0.00000	0.087	0.068	0.089	0.077	0.086	6.8e-27	2.4e-21	1.5e-27	4.6e-24	9.1e-27

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Friendships satisfaction	6.6	8.2	12.7	-3.6	-2.5	-3.2	-2.8	-3.4	-1.1
Heart disease (mother)	5.7	7.0	10.1	2.8	3.2	2.8	2.5	1.9	2.5
Pulse wave Arterial Stiffness index	5.2	6.1	8.6	-2.8	-2.9	-2.4	-2.7	-0.9	-2.4
Irritable Bowel Disease (IBD)	4.7	11.2	17.1	-3.2	-3.5	-2.8	-4.1	-2.7	-3.6
Diastolic blood pressure, automated reading	4.6	14.3	29.2	2.7	5.4	3.4	3.2	0.9	5.2
Neuroticism	4.5	10.9	20.6	-2.8	-2.2	-4.4	-4.5	-3.6	-0.2
Ulcerative Colitis (UC)	4.2	7.8	11.4	-2.8	-2.8	-2.0	-3.4	-2.9	-2.8
Pulse wave peak to peak time	4.2	4.9	6.9	2.5	2.5	2.3	2.6	1.0	2.0
Loneliness, isolation	4.2	5.9	9.1	-2.6	-1.9	-3.0	-2.8	-2.4	-1.4
Mouth/teeth dental problems	4.1	6.3	8.8	2.9	2.5	2.3	3.0	2.5	1.6
Pulse wave reflection index	4.1	5.1	6.9	-2.4	-2.6	-2.5	-2.4	-0.3	-2.5
Falls in the last year	3.9	5.3	11.0	2.4	3.3	1.6	1.6	-0.2	3.2
Family relationship satisfaction	3.8	4.6	8.1	-2.9	-2.1	-2.8	-1.8	-1.7	-1.2
Number of incorrect matches in round	3.7	6.2	12.2	2.4	3.5	1.8	2.5	0.8	3.0
Medication: Bendroflumethiazide	3.7	5.6	11.0	2.4	2.8	2.2	1.5	1.2	3.3
Crohns Disease (2017)	3.4	7.5	10.7	-2.3	-3.0	-2.6	-3.3	-1.7	-3.3
Fasting Glucose	3.4	4.0	7.0	-2.1	-1.7	-2.6	-2.2	-1.2	-1.9
Blood Eosinophil Count	3.4	26.0	38.2	4.9	6.0	6.2	4.6	2.5	5.6
Sensitivity / hurt feelings	3.3	5.6	9.4	-2.0	-1.8	-3.0	-2.8	-3.1	-0.4
Vitamin and mineral supplements	3.3	4.5	8.5	2.2	2.9	2.2	1.2	1.0	2.5
Mouth/teeth dental problems: Dentures	3.2	5.4	7.9	-2.8	-1.5	-2.5	-2.8	-2.4	-1.5
Shortness of breath walking on level ground	3.0	3.5	5.2	2.1	2.3	1.9	1.9	0.6	2.0
Neuroticism (Nagel 2018)	2.9	6.7	12.2	-2.4	-1.4	-3.2	-3.5	-3.2	0.2
Severe depression (siblings)	2.9	3.2	6.2	1.9	1.8	2.5	1.2	1.0	1.9
Pack years adult smoking proportion	2.9	4.4	10.8	-2.0	-0.7	-2.1	-2.5	-3.3	-0.3
Neuroticism score	2.9	6.0	10.2	-2.1	-1.6	-3.2	-3.1	-3.0	-0.1
Ulcerative Colitis	2.8	4.1	6.2	-2.5	-2.4	-1.7	-1.9	-0.8	-2.3
Pulse rate, automated reading	2.7	8.9	18.8	-4.3	-0.6	-2.7	-3.2	-4.0	0.1
Depressed Affect (Nagel 2018)	2.6	5.4	9.5	-2.7	-1.7	-2.5	-3.1	-2.4	-0.6
Medication: Cholesterol lowering	2.6	4.1	10.6	1.3	3.3	2.1	1.6	0.1	2.3
Gout (self-reported)	2.5	3.4	6.6	2.3	2.6	1.2	1.8	1.4	1.4
Ever had bowel cancer screening	2.5	2.9	7.7	-2.2	-0.6	-1.8	-1.2	-2.8	-0.1
Medication: Atenolol	2.4	3.0	5.2	2.3	1.7	1.7	0.7	2.2	1.3
Average weekly red wine intake	2.4	3.6	4.2	2.1	2.0	1.8	1.7	2.0	1.7
Smoking status: Current	2.4	3.9	6.6	-1.9	-0.9	-2.6	-2.4	-2.5	-0.5
Ever depressed for a whole week	2.4	2.9	6.8	1.8	1.4	1.6	2.6	1.4	1.1
Diabetes (father)	2.3	2.9	4.8	-2.2	-1.2	-1.8	-1.9	-1.0	-1.7
Tense / ‘highly strung’	2.3	3.9	10.6	-1.5	-0.7	-2.3	-2.2	-3.3	0.4
Worry (Nagel 2018)	2.2	4.7	9.0	-1.4	-0.8	-3.0	-2.9	-2.8	0.3
Medication: Aspirin	2.2	2.8	6.4	1.2	2.5	1.6	1.6	0.8	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.6	6.0	-1.8	-1.2	-0.8	-2.4	-1.5	-1.4
Myopia	2.2	3.2	7.1	-2.7	-1.6	-1.0	-1.3	-1.9	-1.9
Schizophrenia vs Biploar Disorder	2.1	2.7	6.2	1.7	2.2	0.6	1.4	-0.1	2.5
Ever unenthusiastic/disinterested for a whole week	2.1	2.6	5.7	2.1	1.4	1.0	2.4	0.8	1.4
Medication for pain relief, constipation, heartburn	2.1	3.5	8.0	-1.4	-2.8	-1.7	-1.6	0.6	-2.3
Smoking status: Previous	2.1	3.1	6.0	2.1	1.0	2.5	1.1	1.8	1.5
Supplements: Calcium	2.1	2.3	6.1	-1.2	-2.5	-1.1	-0.3	0.4	-2.2
Pack years of smoking	2.1	3.1	8.6	-1.6	-0.2	-1.7	-2.2	-2.9	0.1
Depression (Nagel 2018)	2.0	3.0	5.7	-2.4	-2.2	-0.9	-1.3	-1.8	-1.3
Current tobacco smoking	2.0	3.2	6.1	-1.7	-0.9	-2.5	-2.2	-2.1	-0.4
Miserableness	2.0	3.5	7.7	-2.2	-1.5	-2.0	-2.8	-1.4	-0.7
Ever had hysterectomy (womb removed)	1.9	2.2	4.0	1.5	1.1	1.8	2.0	1.1	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.6	5.0	-2.2	-2.1	-0.9	-0.6	-1.2	-1.8
Exposure to tobacco smoke at home	1.9	2.1	3.9	1.5	2.0	1.5	1.2	0.3	1.6
Mineral and other dietary supplements	1.9	2.5	5.1	1.9	2.2	1.8	0.5	0.8	1.5
Major Depression (MDD)	1.8	2.2	3.7	1.8	1.9	1.4	1.3	0.6	1.5
Number of treatments/medications taken	1.8	3.3	9.4	1.4	3.1	0.6	1.6	-0.7	2.2
Medication: Levothyroxine sodium	1.8	3.1	7.5	2.1	1.1	1.1	1.8	2.7	0.9
Hypothyroidism/myxoedema (self-reported)	1.8	3.6	5.4	2.1	1.8	1.1	2.2	2.3	1.5
Medication: Aspirin	1.7	2.2	5.7	1.0	2.4	1.3	1.2	0.6	1.6
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	4.7	2.2	1.5	0.8	0.8	0.8	1.0
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	5.7	-1.5	-0.2	-1.8	-0.6	-2.4	-0.1
Illnesses of father: Heart disease	1.6	2.2	5.0	2.0	1.1	1.4	0.9	2.2	0.5
Neuroticism (2016)	1.5	2.2	3.6	-1.4	-1.1	-1.9	-1.7	-1.7	-0.5
Multivitamins +/- minerals	1.5	1.9	4.0	-1.4	-2.0	-1.5	-0.5	-0.4	-1.7
Illnesses of mother	1.5	1.8	4.6	-1.0	-2.1	-1.3	-0.3	-0.6	-1.8
Breastfed as a baby	1.5	1.9	5.2	1.1	2.3	0.5	1.3	-0.1	1.7
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	6.7	-2.1	-2.6	-1.5	-1.1	-0.7	-1.9
Breast Cancer	1.4	3.4	8.0	1.6	1.2	2.8	1.8	2.0	1.1
Blood Red Count	1.4	13.3	18.4	3.6	4.3	3.5	3.9	1.9	4.2
Comparative height size at age 10	1.4	7.9	10.8	-3.3	-3.1	-2.8	-1.6	-2.8	-3.0
Number of full sisters	1.4	1.7	3.6	1.9	1.1	1.0	0.0	0.9	1.8
Tinnitus: Yes, now most or all of the time	1.4	1.7	4.5	-0.9	-0.2	-0.8	-2.0	-2.1	0.3
Medication: Atorvastatin	1.4	1.7	4.9	0.9	0.4	1.6	1.4	2.2	0.0
Reaction Time	1.3	2.5	7.0	2.6	1.6	0.5	1.8	0.9	0.9
Fed-up feelings	1.3	2.4	4.3	-1.2	-1.9	-2.1	-1.6	-1.2	-0.8
Qualifications: A levels/AS levels or equivalent	1.3	2.9	6.2	-2.1	-1.2	-1.9	-2.5	-1.0	-0.8
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.4	0.4	-1.4	-0.2	-0.5	1.9	-1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	1.9	3.0	1.4	1.7	1.3	1.4	1.1	1.3
Chronic bronchitis/emphysema (mother)	1.3	1.5	4.0	1.3	1.7	0.6	-0.2	0.2	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.6	4.4	0.8	1.7	0.0	0.3	-1.4	2.1
Back pain experienced in last month	1.3	1.9	3.6	1.9	1.5	1.8	0.9	0.5	1.1
Unable to work because of sickness or disability	1.3	1.7	2.8	-1.2	-0.7	-1.7	-1.4	-1.4	-1.1
HbA1C	1.2	1.3	3.6	1.3	1.9	0.2	1.1	0.5	1.0
Cardiovascular Disease	1.2	4.1	11.8	0.8	3.4	1.4	0.3	-1.1	3.0
Chronotype (morning person)	1.2	2.7	7.2	1.1	2.7	1.2	-0.2	0.7	2.4
Medication: Paracetamol	1.2	1.9	3.7	1.2	1.9	1.0	1.1	-0.9	1.8
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	6.2	-0.1	-2.5	-1.3	-0.6	0.7	-1.7
Mean time to correctly identify matches	1.2	2.4	6.9	2.6	1.6	1.0	1.4	0.8	1.1
Alzheimer’s Disease (including proxy)	1.1	1.6	2.5	1.0	1.6	1.4	1.4	0.1	1.5
Crohns Disease (2012)	1.1	1.8	2.9	-1.2	-1.4	-1.4	-1.4	-0.7	-1.7
Hearing difficulty/problems with background noise	1.1	1.8	3.1	1.4	1.8	0.8	1.3	1.8	0.0
Forced vital capacity (FVC)	1.1	4.2	11.2	-2.1	-3.3	-1.6	-0.4	1.2	-2.3
Fluid intelligence score	1.1	2.2	4.2	-1.8	-1.2	-1.6	-2.1	-1.3	-0.3
Qualifications: College or University degree	1.1	3.5	6.3	-2.4	-2.3	-0.9	-1.5	0.9	-2.5
Commuting to job workplace: Cycle	1.1	1.3	2.9	1.7	-0.0	1.6	1.5	0.4	-0.3
Vascular/heart problems diagnosed by doctor	1.1	3.0	9.7	-1.1	-3.1	-1.3	-0.5	0.8	-2.2
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.4	0.5	1.6	1.9	1.3	-0.1	0.6
Alzheimer’s Disease (in mother)	1.0	1.2	3.0	1.3	0.8	0.9	1.1	1.7	0.2
Coronary Artery Disease (CAD)	1.0	1.1	4.1	0.8	1.0	1.0	0.5	-0.2	2.0
Heart attack	1.0	1.3	3.0	0.7	1.5	1.7	1.2	-0.2	0.5
Allergy	1.0	2.4	6.6	-1.4	-1.8	-0.8	-1.3	-0.5	-2.6
Medication: Simvastatin	1.0	1.5	4.4	1.1	2.1	1.2	0.5	-0.5	1.3
Illnesses of siblings	1.0	1.3	2.9	-1.4	-1.7	-1.1	-0.1	-1.2	-0.8
Glaucoma (self-reported)	1.0	1.1	2.7	-1.4	-1.6	-0.6	-1.3	-0.3	-0.2
Ovarian Cancer	0.9	1.2	2.1	1.5	0.6	1.4	1.4	0.9	0.5
Bipolar Disorder (2011)	0.9	0.8	2.1	-0.6	-0.8	-0.1	-0.6	-1.5	-1.2
Nervous feelings	0.9	1.7	4.8	-0.5	-0.8	-2.2	-1.2	-1.6	-0.6
Pulse rate	0.9	1.5	4.7	0.2	1.6	0.4	-0.3	-1.2	2.2
Happiness	0.9	1.0	2.3	-1.3	-0.7	-1.0	-0.7	-1.5	-0.3
Birth weight	0.9	1.9	4.8	-2.2	-1.6	-0.6	-0.5	0.3	-1.8
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.2	-0.8	-0.4	-1.2	-1.0	-1.8	-0.1
Long-standing illness, disability or infirmity	0.9	1.3	4.0	0.9	2.0	1.1	0.1	-0.0	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.1	1.4	0.7	0.7	1.0	0.7	1.0
Body Mass Index (BMI) (2010)	0.8	1.1	1.9	0.8	1.2	1.0	0.4	1.1	1.4
LDL Cholesterol	0.8	1.2	2.7	-1.4	-0.4	-1.6	-1.2	-0.8	-0.4
Heel T-Score	0.8	6.7	15.5	3.9	2.6	2.0	2.3	1.8	2.2
Hypothyroidism (self reported)	0.8	1.9	3.1	1.8	1.4	0.2	1.6	1.4	1.4
Hearing difficulty/problems: Yes	0.8	1.2	2.9	-1.5	-0.4	-0.7	-1.7	-1.1	-0.5
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.2	0.1	1.0	1.2	1.5	1.0	0.3
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	1.6	-1.3	-0.3	-0.4	-1.2	-1.3	-0.3
Serious illness, injury or assault to yourself	0.8	1.0	1.9	1.0	1.4	0.8	1.2	0.6	0.8
Supplements: Glucosamine	0.8	1.0	2.6	-0.9	-1.6	-0.2	0.2	0.7	-1.4
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	4.0	-0.7	-1.3	-0.5	-2.0	-0.4	0.1
Eye problems/disorders: None of the above	0.8	1.0	2.9	-1.7	-0.5	0.6	0.3	-1.4	-0.7
Medication: Blood pressure	0.8	1.5	4.7	-0.3	2.2	0.7	0.3	-0.3	1.9
Medication: Allopurinol	0.8	1.1	2.5	1.6	1.4	0.2	0.8	0.9	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.5	-0.5	-0.4	-1.1	-0.8	-1.6	-0.9
Breast cancer (self-reported)	0.8	0.9	2.5	-0.6	-0.9	-0.8	-0.6	1.6	-0.9
Illnesses of father: High blood pressure	0.8	0.9	2.2	0.7	1.5	1.5	0.2	0.4	0.8
Irritability	0.8	1.3	2.7	-0.9	-0.2	-1.5	-1.4	-1.6	0.4
Risk taking	0.8	1.1	3.1	-0.5	-1.8	0.3	0.4	0.9	-1.6
Prostate Cancer	0.7	1.0	3.4	-1.0	-0.3	1.9	0.9	-0.8	0.5
Lupus	0.7	1.1	3.0	-0.3	-0.4	-1.7	-1.5	-1.1	-0.1
Primary Biliary Cirrhosis	0.7	1.1	4.6	0.4	0.2	0.9	0.4	2.1	-0.8
Rheumatoid Arthritis	0.7	1.0	1.5	-1.2	-1.2	-0.2	-0.4	-1.2	-1.1
Medication: Metformin	0.7	1.0	2.1	-1.2	0.1	0.3	-1.4	-1.4	-0.7
Taking other prescription medications	0.7	1.0	3.5	0.5	1.9	0.1	0.5	-0.5	1.3
Qualifications: CSEs or equivalent	0.7	0.9	2.3	-0.1	-1.2	-0.9	-1.0	-0.4	-1.5
High blood pressure	0.7	1.9	6.6	0.1	2.6	0.8	-0.4	-1.0	1.7
Hayfever, allergic rhinitis or eczema	0.7	1.4	4.5	0.6	1.4	0.5	1.0	0.6	2.1
Past tobacco smoking	0.7	1.3	2.9	-1.5	-0.9	-1.1	0.0	-0.6	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.7	-1.3	-1.2	-0.9	-0.7	-1.3	-0.8
Pain all over the body in last month	0.7	0.7	1.9	-0.1	-0.6	-1.1	-1.4	-0.7	-0.5
Hair/balding pattern: Pattern 3	0.7	1.0	2.2	0.5	1.5	1.1	0.5	1.1	1.1
Number of live births	0.7	1.0	2.2	1.3	-0.3	0.9	0.9	1.5	-0.2
Standing height	0.7	6.7	19.4	-2.9	-4.4	-0.8	-0.2	0.6	-3.4
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.2	0.9	0.9	1.5	0.5	0.3	0.7
Medication: Amlodipine	0.7	0.9	1.8	-0.2	1.3	0.8	0.8	-1.1	1.1
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.8	0.4	1.0	1.3	0.7	1.0	1.0
Leg fat percentage (right)	0.7	2.4	5.4	1.3	2.3	1.8	1.3	0.4	1.5
Exposure to tobacco smoke outside home	0.7	1.0	2.1	0.9	1.4	-0.0	0.4	-1.0	1.4
Wheeze or whistling in the chest in last year	0.7	1.2	2.4	-0.5	1.1	0.8	-0.4	-1.6	1.5
Neck or shoulder pain in last month	0.7	1.0	2.7	1.1	1.0	1.6	0.6	-0.3	0.8
Overall health rating	0.7	1.6	4.4	-1.3	-0.7	-1.2	-0.5	-2.1	-1.0
Hypertension (Self-reported)	0.7	2.0	6.8	-0.1	2.6	0.8	-0.4	-1.0	1.8
Medication: Gliclazide	0.7	0.8	1.6	0.3	1.2	0.5	1.2	0.4	1.0
Number of self-reported non-cancer illnesses	0.7	1.3	3.4	-0.6	1.4	-0.5	-0.9	-1.9	0.9
Wears glasses or contact lenses	0.7	0.8	2.3	0.6	0.7	1.1	0.6	1.5	-0.3
Medication: Paracetamol	0.7	1.1	2.2	0.4	1.4	0.6	0.4	-1.3	1.5
Mean Putamen Volume	0.6	0.7	1.7	-0.7	0.4	-0.8	-0.6	-1.3	0.7
Blood White Count	0.6	4.7	14.1	1.1	3.2	1.6	0.3	-0.0	3.8
Lung FEV1/FVC ratio	0.6	3.0	7.8	1.2	2.8	1.2	0.6	-1.5	2.1
Relative age of first facial hair	0.6	1.1	2.4	1.5	0.4	0.9	1.5	1.0	0.5
Alcohol usually taken with meals	0.6	0.9	1.4	1.2	0.8	1.1	0.2	1.1	1.0
Financial difficulties in last 2 years	0.6	0.7	1.7	0.7	0.4	1.3	0.4	1.3	0.6
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	6.1	-1.5	-2.5	-0.9	-0.4	0.7	-1.6
Depression (self-reported)	0.6	0.8	1.7	0.9	1.3	0.1	0.7	-0.5	1.1
Prospective memory result	0.6	0.8	1.6	1.3	1.2	-0.6	-0.4	-0.7	0.9
Medication: Seretide 50 evohaler	0.6	0.6	3.1	0.0	0.2	0.4	1.8	0.1	-0.7
Age at last live birth	0.6	0.9	1.7	0.8	1.3	1.0	0.6	0.2	1.3
Diabetes diagnosed by doctor	0.6	0.9	2.3	-1.5	-0.1	-0.1	-1.4	-0.7	-0.8
Commuting to job workplace: Walk	0.6	0.7	2.6	0.0	-0.9	-0.8	-0.0	-0.4	-1.6
Financial situation satisfaction	0.6	0.7	1.3	1.1	1.1	0.8	0.9	0.0	0.6
Commuting to job workplace: Public transport	0.6	0.7	2.0	0.3	1.4	0.9	0.5	0.8	0.8
Medication: Blood pressure	0.6	1.1	2.4	0.8	1.4	1.1	0.3	0.4	1.5
Leg fat percentage (left)	0.6	2.3	5.7	1.3	2.4	1.8	1.0	0.4	1.4
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	3.3	0.2	-0.4	-0.6	-0.3	1.8	0.7
Heart disease (siblings)	0.6	0.7	2.8	0.7	0.4	0.9	-0.0	1.7	0.3
Schizophrenia (2018)	0.5	1.0	2.8	0.6	1.4	-0.5	-0.0	-0.8	1.7
Alzheimer’s Disease (in father)	0.5	0.6	1.4	-0.4	0.6	0.6	0.3	-1.2	1.0
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.4	-1.6	-0.8	-0.8	-0.8	-1.4	0.4
Systolic Blood Pressure	0.5	2.6	7.6	-1.5	1.9	-0.1	-0.7	-2.8	1.3
Medication: Co-codamol	0.5	0.5	2.2	-0.9	0.1	0.3	0.1	-1.5	0.0
Townsend deprivation index at recruitment	0.5	0.7	1.5	1.2	0.9	0.8	0.3	0.5	0.7
Average weekly fortified wine intake	0.5	0.6	1.4	-0.5	0.3	-1.1	-0.5	-1.2	0.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.0	0.5	0.6	1.4	0.4	0.3	-0.7
Sitting height	0.5	3.5	9.6	-2.8	-3.1	-0.3	-0.8	0.1	-1.7
Diabetes (self-reported)	0.5	0.8	2.8	-1.1	0.1	-0.2	-1.7	-0.7	-0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.7	-0.3	0.4	0.9	0.0	-1.3	1.2
Arm fat percentage (right)	0.5	1.9	3.6	0.8	1.9	1.9	1.3	1.1	0.9
Trunk fat-free mass	0.5	2.7	7.8	-2.8	-2.4	0.0	-0.0	0.8	-1.5
Worrier / anxious feelings	0.5	1.0	2.4	0.4	0.8	-0.5	-0.8	-1.4	1.5
Trunk predicted mass	0.5	2.8	8.0	-2.8	-2.4	-0.1	-0.1	0.7	-1.6
Blood clot in the leg (DVT)	0.5	0.6	2.6	0.2	-0.2	-0.5	-0.5	1.6	0.8
Forced vital capacity (FVC), Best measure	0.5	1.9	5.8	-1.6	-2.4	-1.0	-0.2	-0.1	-1.4
Body fat percentage	0.5	1.8	3.9	1.0	2.0	1.8	1.3	0.5	0.9
Worry too long after embarrassment	0.5	0.8	2.0	-1.4	-0.6	-0.8	-0.8	-1.0	0.4
Number of children fathered	0.5	0.6	2.7	-0.1	-0.6	0.5	-0.5	1.6	-0.3
Alcohol intake frequency.	0.5	1.3	3.2	-1.1	-1.0	-0.5	-0.0	-1.4	-1.8
Leg fat-free mass (right)	0.5	2.6	7.6	-2.8	-2.1	0.1	0.1	0.5	-1.9
Qualifications: nursing, teaching	0.5	0.8	1.3	0.3	1.0	1.1	1.2	1.1	-0.3
Medication for cholesterol	0.5	0.8	1.5	-1.1	-1.1	-1.2	-0.7	-0.0	-0.6
Leg predicted mass (right)	0.5	2.6	7.5	-2.7	-2.1	0.1	0.1	0.5	-1.9
Ever taken oral contraceptive pill	0.5	0.5	0.8	0.9	0.5	0.6	0.8	0.5	0.8
Hearing aid user	0.5	0.6	2.1	0.3	1.0	0.2	-0.4	-0.2	1.4
Medication: Lisinopril	0.5	0.6	1.2	0.9	1.1	0.1	0.7	0.7	0.8
Bipolar Disorder (2018)	0.4	0.6	2.7	-0.5	-0.6	0.1	0.7	-0.2	-1.6
Triglycerides	0.4	0.6	1.9	-1.4	-0.5	-1.0	-0.8	0.0	-0.1
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.5	1.2	0.8	-0.4	0.3	0.5	0.1
Smoking Status	0.4	0.9	3.0	0.6	1.0	0.6	-0.4	0.4	1.7
Systolic blood pressure, automated reading	0.4	1.1	2.7	-1.2	1.6	-0.0	0.5	-1.3	1.0
Medication for hormone replacement therapy	0.4	0.4	1.7	0.2	0.1	1.3	0.1	0.8	0.0
Diabetes (mother)	0.4	0.6	1.7	0.1	0.9	0.2	0.4	-0.7	1.3
Leg fat-free mass (left)	0.4	2.1	6.4	-2.5	-1.8	0.2	0.5	0.6	-1.5
Trunk fat percentage	0.4	1.8	3.8	0.8	1.9	1.9	1.3	0.5	0.8
Stomach or abdominal pain in last month	0.4	0.4	1.3	-0.4	-0.5	-0.9	-0.4	-1.1	0.1
Chronic bronchitis/emphysema (father)	0.4	0.5	1.4	0.4	0.5	1.1	1.2	0.3	0.3
Leg predicted mass (left)	0.4	2.1	6.6	-2.6	-1.8	0.2	0.4	0.6	-1.5
Had other major operations	0.4	0.5	0.8	-0.5	-0.7	-0.8	-0.9	-0.7	-0.3
Loud music exposure frequency	0.4	0.4	1.0	-0.7	-0.6	-0.2	0.1	-0.8	-1.0
Number of full brothers	0.4	0.6	1.7	1.3	0.1	0.5	-0.1	0.7	1.0
Medication: Ibuprofen	0.4	0.5	1.0	-1.0	-0.8	-0.4	-0.2	-1.0	-0.3
Medication: Omeprazole	0.4	0.5	1.3	-1.0	0.2	0.1	-0.7	-1.1	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.1	0.3	0.5	1.1	1.0	0.4	0.2
Had major operations	0.4	0.4	0.8	0.6	0.9	0.7	0.7	0.7	-0.0
Whole body fat-free mass	0.4	2.5	7.7	-2.8	-2.1	0.0	0.2	0.6	-1.6
Arm fat percentage (left)	0.4	1.8	3.3	0.9	1.8	1.7	1.3	1.1	0.7
Eye problems/disorders: Cataract	0.4	0.5	1.3	1.0	-0.3	-0.4	-0.3	1.1	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.9	-0.6	-1.4	-0.3	0.4	-0.6	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.1	0.1	0.5	0.9	0.6	-1.0	0.3
Whole body water mass	0.4	2.6	7.8	-2.8	-2.2	-0.1	0.2	0.6	-1.6
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.5	0.1	-0.4	0.0	-0.3	-0.4	-1.6
Alcohol drinker status: Never	0.4	0.5	1.4	-0.6	0.6	-1.2	-0.1	-0.8	-0.3
Average weekly beer plus cider intake	0.4	0.6	1.8	-1.3	-0.7	-0.9	0.2	-0.9	-0.1
Age at First Birth	0.3	0.5	1.4	0.1	-1.2	-0.1	0.8	0.7	-0.5
HDL Cholesterol	0.3	0.5	1.5	0.7	0.0	0.5	1.2	0.8	-0.5
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.4	-1.2	0.1	-0.2	-1.1	-0.7	-0.4
Average weekly spirits intake	0.3	0.3	1.4	-0.1	-0.4	0.0	-0.0	0.7	-1.2
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.1	-0.6	-0.7	-0.8	-0.3	-1.1	-0.1
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.5	0.6	0.3	0.6	0.7	0.6	0.5
Angina	0.3	0.3	1.4	1.2	0.6	-0.2	0.2	-0.2	0.5
Hand grip strength (right)	0.3	0.8	2.4	0.3	0.5	1.0	0.8	1.6	0.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.9	0.1	0.5	-0.1	0.0	0.0	1.4
High blood pressure (mother)	0.3	0.5	1.1	-0.3	0.0	-1.1	-1.0	-0.8	0.1
Body mass index (BMI)	0.3	1.4	3.3	0.3	1.8	1.6	1.0	0.6	1.2
Trunk fat mass	0.3	1.1	3.4	-0.0	1.1	1.9	1.2	0.8	0.4
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	0.7	0.4	-0.8	0.3	1.0	0.5
Time employed in main current job	0.3	0.3	0.7	-0.4	0.6	-0.8	-0.6	-0.6	0.2
Alcohol intake versus 10 years previously	0.3	0.5	1.5	-0.7	-0.8	-0.6	-0.4	-0.0	-1.2
Lung cancer (father)	0.3	0.3	0.9	0.5	0.9	0.1	0.4	-0.4	0.7
Arm fat mass (right)	0.3	1.1	2.4	-0.1	1.2	1.6	1.2	1.1	0.4
Length of working week for main job	0.3	0.3	1.3	0.1	0.1	0.7	0.3	1.2	-0.3
Birth weight of first child	0.3	0.6	1.1	0.8	-0.0	0.6	1.1	1.0	-0.6
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.7	-0.8	-0.6	-0.4	-0.2	-0.8	-0.8
Arm fat-free mass (right)	0.3	1.6	5.2	-2.3	-1.6	0.1	0.2	0.5	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.8	-0.7	-0.4	-0.3	-0.7	0.3	-0.9
Health satisfaction	0.3	0.3	1.1	0.2	-0.6	-0.4	0.6	0.1	-1.0
Emphysema/chronic bronchitis	0.3	0.4	1.0	0.1	0.9	-0.2	-0.0	-1.0	0.6
Whole body fat mass	0.3	1.3	3.4	0.2	1.1	1.9	1.3	0.9	0.4
Leg fat mass (right)	0.3	1.2	2.8	0.2	1.3	1.7	1.4	0.6	0.6
Arm predicted mass (right)	0.3	1.6	4.7	-2.2	-1.6	0.3	0.4	0.7	-1.1
Suffer from ‘nerves’	0.3	0.5	1.1	-0.1	-0.8	-0.9	-0.6	-1.1	-0.5
Chest pain or discomfort	0.3	0.4	1.4	-0.8	-0.2	0.3	0.6	-0.2	-1.2
Leg pain on walking	0.3	0.4	1.1	0.4	-0.2	-0.4	-0.4	-1.1	-0.8
Supplements: Vitamin C	0.3	0.4	1.2	-0.4	0.1	-0.3	-0.8	-1.1	0.1
Mood swings	0.3	0.5	2.0	-0.0	0.3	-0.6	-0.4	-0.6	1.4
Osteoporosis (self-reported)	0.3	0.4	1.0	-1.0	-0.4	0.4	1.0	-0.0	0.1
Illnesses of father: None of the above (group 1)	0.3	0.4	1.2	0.2	0.4	-0.8	0.1	-1.1	0.6
Arm fat mass (left)	0.3	1.1	2.4	-0.1	1.1	1.6	1.3	1.1	0.3
Guilty feelings	0.3	0.5	1.8	0.4	0.2	-0.4	0.0	-1.3	1.0
Eye problems/disorders: Glaucoma	0.3	0.4	1.1	0.6	0.1	0.4	-0.2	0.8	1.1
High cholesterol (Self-reported)	0.3	0.5	1.5	-0.0	1.2	0.4	0.2	-0.9	0.7
Basal metabolic rate	0.3	1.9	5.9	-2.4	-1.8	0.3	0.4	0.7	-1.4
Arm fat-free mass (left)	0.3	1.5	4.7	-2.2	-1.4	0.3	0.5	0.8	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.3	-0.2	1.2	0.6	-0.2	-0.6	0.6
Leg fat mass (left)	0.3	1.1	2.9	0.1	1.3	1.7	1.2	0.6	0.4
Arm predicted mass (left)	0.3	1.5	4.5	-2.1	-1.5	0.3	0.5	0.6	-1.2
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.6	-1.6	-0.1	0.5	0.1	-0.5	0.9
BMI	0.2	1.1	3.5	-1.2	0.2	1.9	0.7	1.0	0.4
Height	0.2	4.6	11.6	-2.0	-3.4	0.2	0.1	1.4	-3.1
Waist Hip Ratio (WHR)	0.2	1.0	2.1	0.6	1.5	0.6	1.4	-0.6	0.7
Impedance of leg (right)	0.2	0.8	3.7	1.9	0.3	-0.2	0.2	-0.7	0.6
Maternal smoking around birth	0.2	0.3	0.9	0.3	0.4	-0.1	-0.7	-0.5	0.9
Relative age voice broke	0.2	0.2	0.7	0.3	-0.1	0.6	0.8	0.2	0.5
Age when periods started (menarche)	0.2	0.4	1.5	-0.4	-0.9	1.2	-0.0	-0.4	-0.1
Impedance of leg (left)	0.2	0.7	3.5	1.9	0.3	-0.1	-0.2	-0.9	0.3
Waist circumference	0.2	0.8	2.8	-0.2	0.8	1.7	1.1	0.3	0.0
Qualifications: None of the above	0.2	0.4	1.2	0.4	1.1	-0.2	-0.1	-0.6	0.8
Medication: Ramipril	0.2	0.2	0.7	0.4	0.4	0.9	0.4	-0.1	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.5	-0.5	-0.6	-0.4	0.2	0.1	-1.2
Noisy workplace	0.2	0.2	0.6	-0.6	0.2	0.8	-0.1	0.4	-0.3
Medication: Lansoprazole	0.2	0.2	0.7	-0.8	0.4	-0.0	-0.5	-0.6	-0.1
Peak expiratory flow (PEF)	0.2	0.5	1.2	-0.1	0.4	0.7	1.1	0.7	0.9
Headache pain in last month	0.2	0.3	0.7	-0.1	0.8	0.4	0.5	-0.7	0.5
High blood pressure (siblings)	0.2	0.3	0.7	0.6	0.7	0.8	0.1	-0.3	-0.2
Comparative body size at age 10	0.2	0.7	1.3	-0.8	-0.9	-1.1	-0.5	1.1	-0.0
Angina (self-reported)	0.2	0.3	1.0	1.0	0.5	-0.2	0.2	-0.1	0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	-0.1	0.6	0.4	-0.6	0.1	0.7
Illnesses of siblings: Diabetes	0.2	0.2	0.8	-0.9	-0.1	-0.0	-0.4	-0.5	0.1
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.0	-0.5	-0.3	0.1	-0.2	1.0	-0.4
Osteoarthritis (self-reported)	0.2	0.2	1.0	-0.3	-0.1	0.3	1.0	0.2	-0.3
Average weekly champagne plus white wine intake	0.2	0.3	0.8	0.3	0.2	0.9	0.1	0.7	0.3
Mother’s age at death	0.2	0.3	1.3	-0.2	-0.3	-0.2	1.1	0.5	0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.0	-0.3	-0.7	-0.2	1.0	0.1	-0.1
Ever smoked	0.2	0.3	0.9	1.0	-0.3	0.3	-0.1	0.6	0.5
Age started oral contraceptive pill	0.2	0.2	0.6	0.4	-0.1	-0.4	0.7	0.4	0.4
Pain experienced in last month	0.2	0.3	0.9	-0.7	-0.3	-1.0	-0.5	0.3	-0.3
Basal cell carcinoma (self-reported)	0.2	0.2	0.8	-0.2	-0.6	0.1	-0.3	0.1	-0.9
Alcohol drinker status: Previous	0.2	0.3	1.2	0.2	0.3	1.1	0.3	0.6	0.0
Bipolar Disorder or Schizophrenia	0.1	0.2	0.6	0.1	0.7	-0.3	0.4	-0.8	0.3
Schizophrenia (2014)	0.1	0.2	0.9	0.2	0.9	-0.4	0.2	-0.3	0.4
Blood Platelet Count	0.1	1.2	3.3	-1.8	-0.5	0.6	-0.1	-1.7	-0.5
Allergy or Eczema	0.1	0.3	1.0	0.1	-0.0	0.1	1.0	0.7	0.6
Respiratory disease	0.1	0.3	0.6	-0.7	-0.5	-0.6	-0.1	-0.8	0.2
Hand grip strength (left)	0.1	0.2	1.0	-0.4	-0.2	-0.1	0.1	1.0	-0.1
Supplements: Zinc	0.1	0.1	0.2	0.4	-0.1	-0.4	0.1	0.2	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.2	0.6	0.1	0.4	1.1	0.4	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.3	0.0	-0.5	-0.3	0.1	-0.5	-0.4
Weight	0.1	0.7	1.3	-1.1	-0.3	1.1	0.8	0.7	-0.4
Impedance of arm (right)	0.1	0.6	2.5	1.6	0.2	0.4	0.8	0.5	-0.1
Hip circumference	0.1	0.4	0.8	-0.9	-0.4	0.9	0.1	0.5	-0.8
Father’s age at death	0.1	0.2	0.3	0.1	-0.2	0.6	0.5	0.3	0.5
Asthma	0.1	0.2	1.1	-0.2	-0.2	-0.1	-0.1	-1.0	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.4	0.3	0.2	-0.1	0.7	-0.4	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.5	1.5	-0.7	-1.2	-0.4	-0.1	-0.5	-0.6
Impedance of arm (left)	0.1	0.7	2.6	1.6	-0.3	-0.0	0.7	0.5	-0.8
Hair/balding pattern: Pattern 4	0.1	0.3	0.8	0.5	0.5	-0.5	0.4	0.9	-0.0
Age at first live birth	0.1	0.2	0.7	-0.3	0.2	0.1	0.0	-0.5	0.9
Migraine (self-reported)	0.1	0.2	0.7	0.2	0.8	-0.0	0.3	0.5	0.2
Asthma (self-reported)	0.1	0.3	1.3	-0.3	-0.3	-0.0	-0.3	-1.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.9	0.3	0.3	0.1	0.9	0.9	0.1
Number of operations (self-reported)	0.1	0.2	0.5	-0.0	-0.1	-0.0	-0.7	-0.1	-0.7
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.4	-0.4	-0.2	-0.6	-0.6	-0.1	0.1
Fractured/broken bones in last 5 years	0.1	0.1	0.2	0.0	0.1	0.4	0.5	0.4	-0.1
Cholesterol lowering medication	0.1	0.2	0.4	0.6	0.7	0.0	0.6	0.2	0.1
Impedance of whole body	0.1	0.7	3.8	1.9	0.2	0.1	0.3	-0.4	-0.1
Lung FVC	0.0	0.2	0.4	0.1	-0.4	0.3	0.1	0.7	0.5
Hair Pigment	0.0	0.8	3.1	0.9	0.5	-0.2	0.4	1.8	0.4
Tanning	0.0	0.0	0.1	-0.1	-0.1	0.2	-0.2	0.0	-0.2
Had menopause	0.0	0.0	0.1	0.0	-0.0	-0.4	-0.1	-0.1	0.3
Knee pain experienced in last month	0.0	0.0	0.1	0.1	-0.3	0.1	0.1	-0.0	0.1

Hub : Genes

ACVR2A

Models

Trait associations