Hub : Genes

SLC9A10

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Cervical Squamous Cell Carcinoma	0.110	0.057	0.0010	0.066	0.059	0.048	NA	0.064	0.00037	0.00076	2.2e-03	NA	0.00044
2	TCGA	Pheochromocytoma and Paraganglioma	0.127	0.069	0.0011	0.033	0.090	0.106	NA	0.078	0.01900	0.00019	5.2e-05	NA	0.00051
3	TCGA	Soft Tissue Sarcoma	0.093	0.054	0.0089	-0.004	0.017	0.007	NA	0.000	0.78000	0.03400	1.2e-01	NA	0.34000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.6	1.0	-0.1	-1.0	1.0
Bipolar Disorder or Schizophrenia	0.1	0.3	0.5	-0.0	-0.7	0.7
Depressed Affect (Nagel 2018)	0.3	0.7	1.5	-0.4	0.7	-1.2
Depression (Nagel 2018)	0.1	0.2	0.3	0.4	-0.5	-0.5
Intelligence (Savage-Jansen 2018)	0.2	0.8	1.4	-0.9	1.2	0.4
Neuroticism (Nagel 2018)	0.1	0.3	0.9	0.1	0.9	-0.0
Schizophrenia (2018)	0.0	0.0	0.0	0.0	-0.1	0.1
Schizophrenia vs Biploar Disorder	0.3	0.4	0.9	1.0	0.2	-0.5
Worry (Nagel 2018)	0.1	0.2	0.3	0.3	0.5	-0.5
Alzheimer’s Disease (in mother)	0.3	0.3	0.5	-0.7	0.4	0.5
Alzheimer’s Disease (in father)	0.9	1.0	2.9	-0.2	-0.1	1.7
Alzheimer’s Disease (including proxy)	1.0	1.4	3.0	-1.1	0.4	1.7
Crohns Disease (2017)	0.8	1.7	4.5	0.6	-0.4	2.1
Irritable Bowel Disease (IBD)	1.6	3.8	8.5	2.9	-1.7	0.1
Ulcerative Colitis (UC)	4.0	7.6	16.0	4.0	-1.8	-1.9
Major Depression (MDD)	0.2	0.2	0.4	-0.7	-0.1	0.5
Reaction Time	0.0	0.0	0.1	-0.0	-0.3	-0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	-0.2	0.6	0.5
Breast Cancer	0.3	0.6	1.1	-0.4	1.1	-0.7
Ovarian Cancer	0.3	0.4	0.7	0.5	-0.5	-0.8
Prostate Cancer	0.2	0.3	0.8	-0.9	0.3	0.2
Age at First Birth	2.1	3.1	5.7	1.6	-1.0	-2.4
Bipolar Disorder (2011)	0.4	0.3	0.8	-0.5	-0.9	-0.3
Body Mass Index (BMI) (2010)	1.0	1.4	1.7	1.3	-1.3	-0.9
Coronary Artery Disease (CAD)	0.5	0.6	1.0	0.5	-1.0	-0.6
Crohns Disease (2012)	1.3	2.0	5.5	-0.8	-0.1	2.4
Mean Putamen Volume	0.4	0.4	0.7	0.6	0.4	0.8
Fasting Glucose	0.9	1.1	2.4	-1.6	0.7	0.7
HbA1C	2.4	2.6	4.9	-2.2	1.2	1.2
HDL Cholesterol	1.6	2.6	5.8	1.4	-0.4	-2.4
LDL Cholesterol	0.2	0.3	0.6	0.3	0.8	0.5
Lupus	1.7	2.5	4.5	-2.1	1.4	1.0
Neuroticism (2016)	0.6	0.8	1.1	-0.6	1.0	1.1
Primary Biliary Cirrhosis	0.8	1.2	2.1	1.1	-1.5	-0.5
Rheumatoid Arthritis	1.4	1.9	3.8	-1.3	1.9	-0.3
Schizophrenia (2014)	0.0	0.0	0.0	0.1	-0.0	0.1
Triglycerides	1.6	2.6	4.3	-2.1	1.3	1.3
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.7	-0.4	0.4	-0.9
Ulcerative Colitis	1.7	2.5	3.4	1.8	-0.9	-1.9
Blood Eosinophil Count	3.6	27.7	68.0	0.2	3.9	8.2
Blood Platelet Count	0.1	1.0	1.9	1.4	-0.2	1.0
Blood Red Count	0.0	0.2	0.2	-0.5	-0.2	0.5
Blood White Count	0.1	0.5	0.6	-0.8	-0.5	0.8
Heel T-Score	0.3	2.1	5.5	-0.2	-0.9	2.3
BMI	0.8	4.7	10.2	-3.2	1.8	0.8
Height	0.1	2.8	6.3	-1.3	2.5	0.5
Waist Hip Ratio (WHR)	0.1	0.3	0.9	-0.2	-0.3	-0.9
Systolic Blood Pressure	0.1	0.4	0.5	-0.5	-0.7	0.7
Smoking Status	0.9	2.2	2.5	-1.6	1.5	1.4
Allergy or Eczema	0.1	0.2	0.3	-0.6	0.5	0.2
Cardiovascular Disease	0.1	0.3	0.7	-0.8	0.6	-0.0
Hypothyroidism (self reported)	0.2	0.5	0.9	-1.0	-0.8	-0.0
Respiratory disease	1.2	2.7	5.5	-1.2	1.0	2.4
Type 2 Diabetes (T2D) (2018)	2.5	4.7	11.1	-1.6	3.3	0.5
Lung FEV1/FVC ratio	0.1	0.5	1.3	-1.1	-0.3	-0.4
Lung FVC	0.6	2.9	4.0	1.7	-2.0	-1.4
Neuroticism	0.3	0.7	1.6	0.0	1.3	-0.6
Chronotype (morning person)	0.5	1.2	2.0	-0.9	1.4	1.0
Hair Pigment	0.0	1.0	1.5	1.2	-0.5	-1.1
Tanning	0.1	1.8	2.6	-1.6	1.4	0.8
Hand grip strength (left)	0.1	0.3	0.6	0.0	-0.5	0.8
Number of treatments/medications taken	1.0	1.8	2.7	-1.2	1.0	1.6
Average weekly spirits intake	1.1	1.4	2.3	1.5	-1.3	-0.4
Sensitivity / hurt feelings	0.2	0.4	0.7	0.0	0.9	0.6
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.6	0.4	-0.2	-0.7
Hearing difficulty/problems: Yes	0.1	0.1	0.2	-0.3	0.1	-0.4
Relative age of first facial hair	0.1	0.3	0.7	0.9	0.1	-0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.0	0.1	-0.5	-1.4
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.3	-0.0	0.4	-0.5
Ever had hysterectomy (womb removed)	0.6	0.7	1.4	-0.5	0.7	1.2
Systolic blood pressure, automated reading	0.2	0.6	1.3	-1.1	-0.3	0.7
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.1	1.1	-0.0	-0.7
Angina	1.6	2.1	3.4	-1.9	1.2	1.2
Medication for hormone replacement therapy	0.6	0.7	1.6	1.3	-0.0	-0.6
Vitamin and mineral supplements	1.6	2.2	4.1	1.5	-2.0	-0.4
Supplements: Zinc	0.7	0.8	1.1	-0.8	0.6	1.1
Medication: Co-codamol	0.0	0.0	0.0	-0.0	-0.1	0.2
Medication: Metformin	0.3	0.5	1.2	-0.2	1.1	0.4
Diabetes (father)	1.4	1.8	4.2	2.0	-1.1	0.1
Diabetes (mother)	0.3	0.4	0.8	0.4	0.9	-0.4
Severe depression (siblings)	0.2	0.2	0.5	0.7	-0.3	0.0
Pack years adult smoking proportion	0.6	0.9	2.0	1.4	-0.4	-0.7
Impedance of leg (right)	0.2	0.8	1.8	0.6	1.4	0.4
Leg fat-free mass (left)	0.3	1.5	3.4	-1.8	1.1	-0.1
Trunk fat percentage	0.9	3.6	5.7	-2.2	2.4	0.7
Hand grip strength (right)	0.2	0.5	0.8	0.9	-0.7	-0.4
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.3	-0.4	0.2
Current tobacco smoking	0.0	0.1	0.2	0.0	0.5	0.1
Average weekly fortified wine intake	0.5	0.6	1.7	0.4	-1.3	-0.0
Maternal smoking around birth	0.0	0.0	0.0	0.1	0.2	0.1
Fed-up feelings	0.1	0.2	0.3	0.5	0.3	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	0.4	0.1	-0.5
Relative age voice broke	1.5	2.2	2.6	1.5	-1.3	-1.6
Taking other prescription medications	2.9	4.5	5.7	-2.2	2.4	1.7
Age when periods started (menarche)	0.3	0.7	2.2	1.5	-0.1	0.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	0.0	0.7	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.6	0.6	-0.5	0.8
Tinnitus: Yes, but not now, but have in the past	1.8	2.0	2.3	1.5	-1.3	-1.4
Qualifications: CSEs or equivalent	1.7	2.3	3.9	1.2	-2.0	-1.2
Serious illness, injury or assault to yourself	0.4	0.5	0.7	-0.7	0.5	-0.9
High blood pressure	0.1	0.3	0.7	-0.8	0.3	-0.1
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.3	-0.5	-0.4	0.3
Multivitamins +/- minerals	0.7	0.9	1.0	-1.0	1.0	0.9
Stomach or abdominal pain in last month	0.3	0.3	0.6	-0.8	0.7	-0.0
Supplements: Glucosamine	0.2	0.3	0.8	-0.9	0.2	0.1
Diverticular disease/diverticulitis (self-reported)	2.4	2.8	4.4	-2.1	1.2	1.6
Medication: Atenolol	0.4	0.6	0.7	-0.4	0.9	0.9
Medication: Levothyroxine sodium	0.4	0.7	1.5	-0.7	-0.4	-1.2
Sitting height	0.1	0.7	1.0	-1.0	1.0	-0.1
Chronic bronchitis/emphysema (father)	0.5	0.6	0.9	-0.5	0.9	1.0
High blood pressure (mother)	0.3	0.4	1.0	1.0	-0.4	0.2
Body mass index (BMI)	0.5	1.9	5.2	-2.3	0.7	0.4
Impedance of leg (left)	0.1	0.7	1.4	0.2	1.2	0.8
Leg predicted mass (left)	0.3	1.5	3.4	-1.8	1.1	-0.0
Trunk fat mass	0.7	3.2	4.8	-2.2	2.1	0.6
Waist circumference	0.9	3.2	7.4	-2.7	1.3	0.7
Number of incorrect matches in round	1.4	2.3	5.1	-2.2	0.8	1.1
Past tobacco smoking	0.9	1.7	2.8	1.5	-1.7	-0.1
Alcohol usually taken with meals	0.2	0.3	0.8	-0.9	-0.3	0.3
Nervous feelings	0.0	0.1	0.2	0.4	0.0	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.3	-0.3	1.1	0.2
Hearing difficulty/problems with background noise	0.3	0.4	0.6	0.6	-0.8	-0.7
Hair/balding pattern: Pattern 2	0.6	0.8	1.3	1.0	-1.1	-0.1
Had menopause	1.1	1.4	3.0	0.0	-1.7	-1.1
Had other major operations	1.3	1.6	2.5	-1.6	1.1	1.1
Forced vital capacity (FVC)	0.3	1.1	1.6	1.2	-0.3	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.1	0.5	-1.2	1.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.2	1.1	-1.1	0.4
Qualifications: None of the above	0.5	1.0	1.5	-1.2	1.1	0.6
Financial difficulties in last 2 years	1.2	1.5	4.1	-0.2	2.0	0.8
Mouth/teeth dental problems	2.0	3.1	5.3	2.3	-0.4	-1.9
Heart attack	0.6	0.8	1.5	-0.7	-0.6	1.2
Allergy	0.6	1.5	2.2	1.5	-0.2	-1.5
Pain all over the body in last month	0.5	0.6	1.0	-0.4	-1.0	0.8
Diabetes (self-reported)	0.5	0.8	2.2	-0.5	1.5	0.1
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.1	-0.1	-0.1	-0.3
Medication: Ramipril	0.5	0.7	0.9	0.7	-0.9	0.9
Medication: Simvastatin	0.2	0.3	0.5	-0.7	0.5	-0.4
Fluid intelligence score	0.3	0.6	0.8	-0.6	0.9	0.8
Illnesses of siblings	0.3	0.4	0.7	0.8	-0.2	-0.8
Neuroticism score	0.4	0.9	2.0	0.2	1.4	-0.9
Weight	0.6	2.9	6.4	-2.5	1.5	0.2
Impedance of arm (right)	0.2	0.8	1.1	0.4	1.0	1.1
Arm fat percentage (right)	0.4	1.7	3.5	-1.9	1.1	0.5
Trunk fat-free mass	0.1	0.7	2.0	-1.4	0.0	-0.4
Hip circumference	0.4	1.9	4.6	-2.1	0.8	0.6
Time employed in main current job	2.2	2.6	5.4	-2.3	1.3	0.8
Alcohol intake versus 10 years previously	0.8	1.1	2.5	-0.8	1.6	0.5
Father’s age at death	1.5	2.0	4.1	-0.8	1.1	2.0
Worrier / anxious feelings	0.1	0.2	0.6	-0.2	0.7	0.2
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	3.7	1.0	-0.7	-1.9
Falls in the last year	1.3	1.7	2.6	-1.6	1.6	0.4
Hair/balding pattern: Pattern 3	0.3	0.5	1.1	0.1	-1.0	-0.7
Number of live births	0.3	0.4	0.7	-0.8	-0.7	-0.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	1.9	1.3	-0.5	-1.4
Pulse rate	0.3	0.6	1.5	-1.2	-0.5	0.1
Happiness	0.3	0.4	0.7	-0.3	-0.9	-0.6
Noisy workplace	0.5	0.6	1.2	1.1	-0.4	-0.6
Qualifications: A levels/AS levels or equivalent	0.7	1.5	2.8	1.0	-0.8	-1.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.6	-0.6	0.4	0.8
Mouth/teeth dental problems: Dentures	1.4	2.3	3.3	-1.8	1.1	1.6
Asthma	3.4	6.7	10.3	-2.3	2.1	3.2
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	5.2	2.3	-0.2	-1.0
Medication: Cholesterol lowering	0.2	0.3	0.5	-0.6	0.7	-0.0
Depression (self-reported)	0.7	0.8	1.6	-0.4	0.9	1.2
Medication: Lansoprazole	0.2	0.2	0.5	-0.3	0.7	0.0
Prospective memory result	0.9	1.0	1.6	-1.2	0.2	1.3
Lung cancer (father)	0.3	0.4	0.7	-0.9	0.3	0.6
Illnesses of mother	0.7	0.8	1.8	-1.4	0.7	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.8	0.7	-0.1	-1.3
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	-0.5	-0.1	0.6
Impedance of arm (left)	0.3	1.2	1.9	0.6	1.4	1.2
Arm fat mass (right)	0.4	1.8	4.3	-2.1	1.0	0.2
Trunk predicted mass	0.1	0.8	2.1	-1.4	-0.0	-0.4
Standing height	0.1	1.3	3.0	-1.0	1.7	0.1
Length of working week for main job	0.1	0.1	0.2	-0.0	0.4	0.4
Exposure to tobacco smoke at home	0.1	0.2	0.4	0.3	0.6	0.1
Breastfed as a baby	0.2	0.2	0.6	0.0	0.1	-0.7
Tense / ‘highly strung’	0.4	0.7	1.2	-0.3	1.1	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.0	-1.1	1.1	1.4
Hair/balding pattern: Pattern 4	0.4	0.9	1.8	-0.9	1.3	-0.1
Birth weight of first child	0.8	1.5	3.2	-1.8	0.5	0.9
Peak expiratory flow (PEF)	0.1	0.3	0.7	0.8	0.1	-0.6
Pulse wave reflection index	0.4	0.5	0.7	-0.3	0.8	0.8
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.0	-0.5	1.0	0.2
Loud music exposure frequency	0.1	0.2	0.5	-0.1	0.7	0.0
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.6	-1.3	-0.0	-0.2
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	2.1	-1.2	1.1	1.5
Blood clot in the leg (DVT)	0.5	0.6	1.3	-0.5	-0.4	1.2
Medication: Paracetamol	0.5	0.9	1.3	-0.7	1.1	-0.9
Headache pain in last month	0.0	0.0	0.1	0.3	0.1	0.1
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	0.2	0.2	0.3
Glaucoma (self-reported)	0.6	0.7	1.0	0.9	-1.0	-0.4
Gout (self-reported)	0.1	0.1	0.2	0.4	-0.2	-0.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.2	-1.1	-1.0	-0.4
Medication: Amlodipine	1.0	1.4	3.8	-2.0	-0.5	-0.0
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.8	-0.6	0.5	1.7
Birth weight	1.0	2.1	2.3	-1.3	1.5	1.5
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.0	-1.0	0.4	1.0
High blood pressure (siblings)	0.4	0.6	1.7	-1.3	-0.1	0.2
Forced vital capacity (FVC), Best measure	0.3	1.1	2.1	1.1	-0.2	-1.4
Body fat percentage	0.9	3.4	5.4	-2.3	2.1	0.6
Leg fat percentage (right)	0.9	3.4	6.0	-2.4	1.9	0.7
Arm fat-free mass (right)	0.2	1.2	3.1	-1.8	0.6	-0.5
Exposure to tobacco smoke outside home	0.4	0.5	1.1	1.0	0.2	0.6
Comparative body size at age 10	0.1	0.4	1.1	0.2	-1.1	0.2
Number of full brothers	2.7	3.3	6.4	-2.5	1.2	1.5
Worry too long after embarrassment	0.2	0.4	1.0	0.3	1.0	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.6	-1.0	0.4	1.3
Wheeze or whistling in the chest in last year	1.0	1.8	3.7	-1.2	1.9	0.5
Number of children fathered	0.9	1.0	2.1	1.5	-0.8	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.2	0.6	0.2	-1.5
Age at first live birth	0.1	0.2	0.4	-0.3	0.6	-0.4
Pulse wave peak to peak time	0.2	0.2	0.4	0.5	0.3	-0.6
Health satisfaction	0.2	0.3	0.8	-0.3	-0.9	0.0
Shortness of breath walking on level ground	0.2	0.3	0.5	0.5	-0.7	0.1
Qualifications: College or University degree	1.1	3.4	4.6	2.1	-1.9	-1.4
Eye problems/disorders: None of the above	0.5	0.6	1.5	-0.6	0.1	1.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	-0.5	0.7	0.0
Emphysema/chronic bronchitis	0.4	0.5	1.0	0.6	-1.0	-0.0
Medication for pain relief, constipation, heartburn	0.5	0.9	1.3	0.1	-1.1	1.2
Neck or shoulder pain in last month	0.1	0.2	0.4	0.3	0.1	0.6
Medication: Blood pressure	0.5	0.9	1.1	1.0	-0.8	-1.1
Angina (self-reported)	2.0	2.7	4.2	-2.1	1.3	1.4
Migraine (self-reported)	0.2	0.2	0.6	-0.2	0.4	-0.7
Medication: Ibuprofen	0.9	1.0	2.6	1.6	-0.3	-0.6
Medication: Allopurinol	0.1	0.1	0.2	-0.4	0.3	0.4
Medication: Omeprazole	0.9	1.1	2.0	-1.1	0.3	1.4
Medication: Seretide 50 evohaler	0.1	0.1	0.1	0.1	-0.4	0.3
Mean time to correctly identify matches	0.3	0.6	1.1	-0.7	-0.5	1.1
Heart disease (mother)	0.6	0.8	1.5	0.9	-0.3	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	1.1	1.1	-0.7	0.3
Whole body fat mass	0.7	2.9	5.1	-2.2	1.9	0.4
Leg fat mass (right)	0.9	3.6	6.8	-2.6	2.0	0.4
Arm predicted mass (right)	0.3	1.4	3.6	-1.9	0.7	-0.4
Pulse rate, automated reading	0.4	1.3	3.8	-2.0	0.2	0.1
Alcohol intake frequency.	0.2	0.4	1.0	0.2	1.0	0.3
Comparative height size at age 10	0.7	3.6	7.0	-1.9	2.6	0.2
Number of full sisters	1.1	1.3	2.6	-0.5	1.6	1.1
Suffer from ‘nerves’	0.1	0.1	0.2	0.3	-0.0	-0.4
Overall health rating	0.2	0.4	0.9	-0.5	-0.2	0.9
Chest pain or discomfort	0.5	0.8	1.2	-0.8	0.6	1.1
Had major operations	0.2	0.3	0.7	-0.9	-0.1	0.1
Age at last live birth	0.1	0.1	0.1	0.3	-0.3	-0.3
Family relationship satisfaction	1.7	2.1	4.4	2.1	-0.9	-0.9
Leg pain on walking	0.4	0.5	0.7	0.8	-0.7	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	0.9	-0.4	0.9	-0.5
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.8	0.7	0.9	0.4
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.1	-0.1	-0.9	1.1
Medication: Aspirin	0.4	0.5	0.9	-1.0	0.7	-0.1
Supplements: Vitamin C	0.5	0.6	0.8	-0.9	0.5	-0.9
Knee pain experienced in last month	1.3	2.1	3.9	-0.1	-1.5	-2.0
Hypertension (Self-reported)	0.1	0.4	0.8	-0.9	0.7	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.7	-0.9	0.7	0.4
Illnesses of father: Heart disease	0.5	0.7	1.1	-1.0	0.4	1.0
Illnesses of siblings: Diabetes	0.9	1.1	3.3	0.1	0.4	1.8
Smoking status: Previous	1.3	2.0	3.8	-2.0	1.3	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.2	0.3	-0.4	-0.0
Whole body fat-free mass	0.2	1.1	3.0	-1.7	0.5	-0.2
Leg fat-free mass (right)	0.3	1.5	3.7	-1.9	0.9	0.1
Arm fat percentage (left)	0.5	1.8	3.4	-1.8	1.3	0.5
Average weekly red wine intake	0.8	1.2	2.4	0.5	-1.0	-1.5
Handedness (chirality/laterality): Left-handed	2.9	3.5	4.6	-2.1	1.5	1.9
Mood swings	0.2	0.4	1.2	-0.3	1.1	-0.2
Loneliness, isolation	0.2	0.3	0.9	-0.1	0.9	-0.0
Long-standing illness, disability or infirmity	0.8	1.2	1.9	-1.4	0.9	0.9
Ever had bowel cancer screening	0.2	0.3	0.6	-0.4	-0.1	0.8
Diabetes diagnosed by doctor	1.5	2.4	4.6	-1.4	2.1	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	-0.4	-0.1	-0.3
Friendships satisfaction	2.3	2.8	3.7	1.9	-1.9	-1.1
Qualifications: nursing, teaching	0.1	0.2	0.5	-0.3	0.1	0.7
Commuting to job workplace: Walk	1.2	1.3	2.0	-1.3	1.4	0.3
Eye problems/disorders: Cataract	0.2	0.2	0.3	0.1	0.6	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	-0.5	-0.8	-0.3
Medication for cholesterol	0.3	0.4	0.7	-0.1	0.8	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.4	-1.2	0.9	0.4
Back pain experienced in last month	1.1	1.7	3.6	0.7	-0.9	-1.9
Mineral and other dietary supplements	0.3	0.4	0.9	1.0	-0.2	0.6
Breast cancer (self-reported)	0.4	0.4	0.9	-1.0	0.4	0.5
Asthma (self-reported)	3.2	6.3	10.7	-2.1	1.9	3.3
Osteoporosis (self-reported)	0.3	0.3	0.8	0.9	-0.3	-0.2
Osteoarthritis (self-reported)	1.7	2.2	4.8	0.8	-2.2	-1.1
Medication: Aspirin	0.6	0.8	1.6	-1.3	0.7	0.3
Medication: Gliclazide	0.3	0.3	0.6	-0.5	0.8	0.3
Illnesses of father: None of the above (group 1)	0.5	0.6	1.0	0.7	-0.6	-1.0
Smoking status: Current	0.1	0.2	0.6	0.1	0.7	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.5	0.5	-1.1	-1.2
Whole body water mass	0.2	0.9	2.3	-1.5	0.4	-0.4
Leg predicted mass (right)	0.3	1.5	3.7	-1.9	0.8	0.2
Arm fat mass (left)	0.4	1.8	4.4	-2.1	1.1	0.2
Number of self-reported non-cancer illnesses	0.7	1.2	2.1	-1.5	0.5	1.0
Average weekly champagne plus white wine intake	0.2	0.3	0.9	-0.1	-0.0	0.9
Miserableness	1.2	2.0	4.3	-0.7	2.1	-1.1
Guilty feelings	0.6	0.8	1.3	1.1	-0.2	-1.1
Wears glasses or contact lenses	1.9	2.2	3.8	-1.3	1.1	1.9
Ever taken oral contraceptive pill	0.4	0.5	0.7	0.8	0.3	-0.8
Hearing aid user	0.6	0.7	1.7	-1.3	0.6	-0.1
Mother’s age at death	0.3	0.4	0.9	-1.0	0.2	0.5
Financial situation satisfaction	0.8	1.0	2.6	-0.5	0.4	1.6
Tinnitus: Yes, now most or all of the time	2.3	2.7	6.3	-0.9	1.0	2.5
Commuting to job workplace: Public transport	0.2	0.2	0.4	-0.6	-0.6	-0.0
Eye problems/disorders: Glaucoma	1.4	1.6	2.4	1.4	-1.6	-0.7
Medication: Blood pressure	0.5	1.0	1.6	-1.3	-0.1	1.2
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.7	-1.6	0.2	0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.8	-0.4	0.1	-0.9
High cholesterol (Self-reported)	1.0	1.7	3.8	0.5	-1.1	-1.9
Medication: Bendroflumethiazide	0.2	0.2	0.5	-0.2	-0.4	0.7
Medication: Paracetamol	0.7	1.1	2.9	0.4	-0.5	-1.7
Medication: Lisinopril	0.7	0.9	1.5	-1.0	0.5	1.2
Medication: Atorvastatin	0.5	0.6	1.5	-1.2	0.2	-0.4
Illnesses of father: High blood pressure	0.8	0.9	2.4	0.7	0.1	-1.5
Alcohol drinker status: Never	0.1	0.2	0.3	-0.3	0.5	-0.3
Ever smoked	0.4	0.6	1.4	-0.1	0.7	-1.2
Basal metabolic rate	0.2	1.3	3.3	-1.8	0.7	-0.2
Leg fat percentage (left)	1.1	4.1	8.1	-2.9	1.8	1.0
Arm fat-free mass (left)	0.3	1.4	3.8	-1.9	0.4	-0.3
Number of operations (self-reported)	1.6	2.4	3.8	-1.9	1.1	1.6
Average weekly beer plus cider intake	0.5	0.8	2.2	-0.2	1.5	0.0
Irritability	0.3	0.5	1.0	0.4	1.0	0.6
Risk taking	0.4	0.5	1.3	1.1	-0.2	-0.5
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.6	1.3	-0.1	-1.0
Fractured/broken bones in last 5 years	0.1	0.1	0.3	-0.5	0.1	-0.1
Age started oral contraceptive pill	0.1	0.1	0.3	-0.2	-0.3	-0.5
Diastolic blood pressure, automated reading	0.1	0.4	0.9	-0.9	0.2	0.5
Ever depressed for a whole week	0.4	0.4	0.7	0.8	-0.8	-0.2
Unable to work because of sickness or disability	0.2	0.3	0.4	0.5	-0.6	-0.4
Commuting to job workplace: Cycle	1.1	1.3	3.2	-0.1	-1.8	-0.9
Myopia	0.2	0.2	0.7	0.1	-0.8	-0.2
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.6	1.2	-0.1	-0.4
Cholesterol lowering medication	0.1	0.2	0.3	-0.3	-0.3	-0.5
Medication: Omeprazole (e.g. Zanprol)	2.4	2.9	4.6	-2.1	0.8	1.9
Pain experienced in last month	0.1	0.2	0.3	0.6	-0.4	0.2
Supplements: Calcium	0.7	0.8	1.8	0.1	1.4	0.6
Basal cell carcinoma (self-reported)	3.0	3.6	5.7	1.7	-2.4	-1.5
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	-0.5	-0.4	0.8
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	-0.1	-0.6	1.1
Heart disease (siblings)	1.3	1.6	2.6	1.6	-1.4	-0.4
Alcohol drinker status: Previous	0.1	0.1	0.1	0.2	-0.3	0.2
Pack years of smoking	1.2	1.7	3.5	1.9	-0.9	-0.9
Impedance of whole body	0.2	1.3	2.2	0.7	1.5	1.1
Leg fat mass (left)	1.0	3.9	7.9	-2.8	1.9	0.5
Arm predicted mass (left)	0.3	1.7	4.6	-2.1	0.6	-0.5