Hub : Genes

C3orf17

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.1862	0.0714	0.00480	0.034	NA	0.062	NA	0.064	0.00180	NA	3.5e-05	NA	2.6e-05
2	TCGA	Bladder Urothelial Carcinoma	0.0590	0.0290	0.00005	0.036	0.043	0.035	NA	0.026	0.00048	0.00014	5.3e-04	NA	2.4e-03
3	TCGA	Brain Lower Grade Glioma	0.0924	0.0460	0.00077	0.004	0.024	0.023	NA	0.003	0.11000	0.00089	1.1e-03	NA	1.2e-01
4	TCGA	Pancreatic Adenocarcinoma	0.2200	0.1010	0.00930	-0.005	0.015	-0.001	NA	-0.007	0.65000	0.07500	3.7e-01	NA	8.2e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.2	1.9	5.3	-0.6	-2.3	1.3	0.1
Bipolar Disorder or Schizophrenia	0.6	1.4	2.4	-1.0	-1.5	0.2	-1.5
Depressed Affect (Nagel 2018)	1.0	2.2	4.3	1.1	-0.4	1.8	2.1
Depression (Nagel 2018)	0.6	0.9	2.0	0.9	0.7	0.4	1.4
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.6	-0.3	-0.1	0.9	1.3
Neuroticism (Nagel 2018)	0.1	0.2	0.5	0.3	0.3	0.5	0.7
Schizophrenia (2018)	0.7	1.4	4.1	-0.9	-0.0	-0.8	-2.0
Schizophrenia vs Biploar Disorder	4.4	5.8	7.0	-2.4	2.7	-2.0	-2.5
Worry (Nagel 2018)	0.6	1.3	3.6	-0.6	1.9	-0.9	-0.7
Alzheimer’s Disease (in mother)	0.4	0.4	1.4	-0.5	-0.4	1.2	0.1
Alzheimer’s Disease (in father)	0.3	0.3	0.5	-0.1	0.7	-0.5	0.7
Alzheimer’s Disease (including proxy)	0.2	0.3	0.7	-0.4	0.0	0.9	0.6
Crohns Disease (2017)	0.3	0.6	1.1	0.7	0.8	-1.1	-0.3
Irritable Bowel Disease (IBD)	0.1	0.2	0.3	0.5	-0.2	-0.6	-0.4
Ulcerative Colitis (UC)	0.2	0.5	1.5	-0.2	-1.2	-0.0	-0.5
Major Depression (MDD)	1.0	1.2	2.6	-1.6	-0.4	-1.4	-0.3
Reaction Time	0.9	1.6	4.5	-0.5	-2.1	-1.2	-0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.9	-1.4	0.3	0.5	0.4
Breast Cancer	0.3	0.7	1.5	0.6	-1.2	0.0	0.8
Ovarian Cancer	0.2	0.3	0.6	0.7	0.1	-0.2	0.8
Prostate Cancer	1.0	1.4	3.7	1.9	-0.5	0.7	1.1
Age at First Birth	0.7	1.0	3.1	-1.8	0.7	-0.5	0.5
Bipolar Disorder (2011)	5.7	5.5	8.3	1.6	-2.9	2.5	2.2
Body Mass Index (BMI) (2010)	0.3	0.4	0.8	0.6	-0.3	0.9	0.7
Coronary Artery Disease (CAD)	2.4	2.9	5.5	1.4	1.9	0.4	2.4
Crohns Disease (2012)	0.7	1.1	2.9	-0.0	1.2	-1.7	-0.4
Mean Putamen Volume	0.3	0.3	0.9	1.0	-0.0	-0.4	0.2
Fasting Glucose	2.0	2.4	4.8	0.7	2.0	-2.2	-0.6
HbA1C	0.6	0.7	2.4	-1.6	-0.0	-0.1	-0.7
HDL Cholesterol	0.1	0.1	0.3	-0.5	-0.4	-0.1	0.4
LDL Cholesterol	0.7	1.1	1.4	-1.2	0.9	-1.1	-0.9
Lupus	0.7	1.0	2.3	1.5	1.1	0.1	-0.7
Neuroticism (2016)	0.3	0.5	1.0	0.3	1.0	-0.2	0.9
Primary Biliary Cirrhosis	0.9	1.3	3.1	1.8	1.3	-0.8	-0.1
Rheumatoid Arthritis	0.3	0.4	0.9	-0.2	0.7	0.0	0.9
Schizophrenia (2014)	0.3	0.6	1.2	-0.8	0.1	-0.8	-1.1
Triglycerides	0.7	1.1	1.8	-1.1	0.8	-1.0	-1.3
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.0	-0.3	-0.7	-0.2	1.0
Ulcerative Colitis	0.2	0.2	0.6	0.1	-0.5	0.3	-0.8
Blood Eosinophil Count	2.9	22.3	55.2	0.8	7.4	-2.7	-5.1
Blood Platelet Count	0.3	3.8	7.0	-1.3	2.0	-2.6	-1.6
Blood Red Count	0.0	0.3	0.8	-0.6	-0.1	-0.9	0.1
Blood White Count	0.4	3.1	9.2	-3.0	1.6	0.5	-0.5
Heel T-Score	0.1	0.5	0.8	-0.1	0.7	0.9	0.9
BMI	0.3	1.5	5.0	-0.9	2.2	-0.6	-0.0
Height	0.1	2.0	4.0	-0.9	1.7	-2.0	0.1
Waist Hip Ratio (WHR)	0.3	1.3	2.0	-1.2	1.4	-0.5	-1.2
Systolic Blood Pressure	0.5	2.4	6.0	0.0	2.4	-1.9	-0.5
Smoking Status	1.0	2.4	5.4	0.6	-1.4	1.4	2.3
Allergy or Eczema	1.9	5.0	11.1	0.7	3.3	-1.9	-2.1
Cardiovascular Disease	0.2	0.6	1.4	-1.2	-0.1	-0.1	-1.0
Hypothyroidism (self reported)	1.4	3.3	11.8	3.4	-0.2	0.4	1.1
Respiratory disease	1.3	2.8	8.3	-0.7	1.3	-0.9	-2.9
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.3	0.2	1.5	0.4	-0.2
Lung FEV1/FVC ratio	0.6	3.2	10.7	-0.1	3.3	-1.2	-0.8
Lung FVC	0.7	3.3	8.3	0.9	-2.9	1.6	1.3
Neuroticism	0.1	0.2	0.3	-0.5	0.4	-0.5	-0.5
Chronotype (morning person)	1.2	2.8	4.0	2.0	1.7	1.3	1.6
Hair Pigment	0.0	1.1	2.6	0.4	-1.6	1.2	0.6
Tanning	0.0	0.1	0.3	0.3	-0.1	0.5	0.3
Hand grip strength (left)	0.4	0.9	3.1	0.4	-1.8	0.4	-0.5
Number of treatments/medications taken	0.8	1.5	2.9	-0.3	1.7	-1.4	-1.1
Average weekly spirits intake	1.7	2.1	3.6	-1.9	-1.5	-0.5	-1.5
Sensitivity / hurt feelings	0.2	0.3	0.6	-0.8	-0.2	-0.3	-0.7
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.9	-0.0	2.0	-1.1	0.7
Hearing difficulty/problems: Yes	0.4	0.6	1.9	-0.1	1.4	-0.6	-0.3
Relative age of first facial hair	0.1	0.1	0.4	-0.6	0.0	-0.3	-0.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	3.3	-1.8	0.6	-0.0	-0.7
Ever used hormone-replacement therapy (HRT)	1.9	2.4	4.0	-2.0	-1.8	1.2	-0.9
Ever had hysterectomy (womb removed)	0.8	1.0	1.4	1.1	0.4	1.2	1.1
Systolic blood pressure, automated reading	0.6	1.8	5.1	0.0	2.3	-1.5	0.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.4	0.2	-0.2	-0.3	-1.6
Angina	0.6	0.8	1.9	-1.4	0.3	-0.6	-0.8
Medication for hormone replacement therapy	0.2	0.2	0.4	-0.4	-0.6	-0.4	0.2
Vitamin and mineral supplements	0.4	0.6	1.1	0.1	-1.0	1.1	-0.4
Supplements: Zinc	1.3	1.5	4.4	-0.4	1.0	-2.1	-0.6
Medication: Co-codamol	1.2	1.4	4.2	-0.5	0.0	-2.1	-1.1
Medication: Metformin	0.3	0.5	1.0	0.8	1.0	0.1	-0.5
Diabetes (father)	0.6	0.7	1.3	0.3	0.9	-1.1	-0.9
Diabetes (mother)	0.8	1.0	3.6	-1.9	-0.4	-0.6	-0.2
Severe depression (siblings)	0.3	0.3	0.6	-0.7	0.4	-0.8	0.1
Pack years adult smoking proportion	0.8	1.2	3.3	0.1	1.8	-1.1	0.7
Impedance of leg (right)	0.7	3.2	6.7	-1.9	-0.8	-1.4	-2.6
Leg fat-free mass (left)	0.4	1.9	5.9	0.6	2.4	-0.9	0.6
Trunk fat percentage	0.6	2.6	4.3	-2.1	1.7	-0.8	-1.6
Hand grip strength (right)	0.4	1.2	3.2	-0.3	-1.8	1.2	-0.2
Townsend deprivation index at recruitment	0.5	0.7	2.4	-1.5	0.4	0.2	0.4
Current tobacco smoking	0.7	1.2	1.9	1.2	-0.3	1.1	1.4
Average weekly fortified wine intake	0.4	0.5	1.7	0.0	0.5	-0.2	-1.3
Maternal smoking around birth	0.2	0.3	0.7	0.4	0.4	-0.8	0.3
Fed-up feelings	0.4	0.7	1.8	1.4	-0.0	0.2	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.7	0.6	1.6	-0.6	0.6
Relative age voice broke	0.1	0.2	0.5	-0.7	-0.6	-0.1	0.0
Taking other prescription medications	0.6	0.9	2.7	0.8	1.6	-0.4	0.1
Age when periods started (menarche)	0.1	0.3	1.0	0.3	0.3	-0.3	-1.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.7	0.9	0.6	0.6	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.7	-0.0	-0.1	0.8	0.2
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.7	0.1	1.6	-1.2	-0.9
Qualifications: CSEs or equivalent	0.6	0.8	2.8	1.7	0.3	0.5	0.1
Serious illness, injury or assault to yourself	0.7	0.9	1.7	-1.3	0.6	-1.2	0.1
High blood pressure	0.2	0.7	2.3	-0.5	1.5	0.3	-0.3
Hayfever, allergic rhinitis or eczema	2.3	5.0	11.4	0.1	3.4	-2.1	-2.0
Multivitamins +/- minerals	0.3	0.4	1.0	0.0	1.0	-0.5	0.5
Stomach or abdominal pain in last month	1.1	1.4	4.0	-2.0	-0.6	-0.7	-0.9
Supplements: Glucosamine	0.8	1.0	2.8	0.9	1.7	-0.2	0.7
Diverticular disease/diverticulitis (self-reported)	4.0	4.7	7.6	1.5	-1.2	2.8	2.8
Medication: Atenolol	1.3	1.6	3.0	-1.7	-1.7	0.2	-0.7
Medication: Levothyroxine sodium	1.4	2.3	7.6	2.8	0.3	0.8	0.9
Sitting height	0.3	2.0	4.5	-0.1	2.1	-1.7	-0.7
Chronic bronchitis/emphysema (father)	0.6	0.7	1.9	0.4	1.4	0.9	0.3
High blood pressure (mother)	1.1	1.5	4.2	0.1	-2.0	0.8	1.1
Body mass index (BMI)	0.3	1.2	4.5	-0.6	2.1	0.0	0.2
Impedance of leg (left)	0.7	3.6	7.0	-2.2	-0.5	-1.5	-2.6
Leg predicted mass (left)	0.3	1.8	5.7	0.6	2.4	-0.9	0.7
Trunk fat mass	0.6	2.8	6.5	-1.5	2.5	-1.0	-1.1
Waist circumference	1.1	3.9	13.4	-0.9	3.7	-0.9	-0.7
Number of incorrect matches in round	0.7	1.2	2.0	1.0	0.4	1.3	1.4
Past tobacco smoking	1.0	1.9	4.9	0.5	2.2	-0.9	-1.3
Alcohol usually taken with meals	0.1	0.1	0.2	-0.2	0.5	-0.1	0.4
Nervous feelings	0.8	1.5	2.6	-0.4	1.6	-1.6	-0.8
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	4.8	-1.3	2.2	-1.7	-1.1
Hearing difficulty/problems with background noise	1.1	1.8	2.7	-0.2	1.4	-1.5	-1.6
Hair/balding pattern: Pattern 2	0.5	0.7	1.6	0.1	1.3	-0.8	-0.6
Had menopause	0.5	0.6	1.8	-1.3	0.2	0.6	-0.3
Had other major operations	1.6	2.0	6.0	-2.5	-0.0	-1.4	0.0
Forced vital capacity (FVC)	0.2	0.7	1.6	1.2	-1.1	-0.3	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.3	-0.5	-1.5	1.0	0.5
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	3.6	0.1	-1.9	-1.0	-0.5
Qualifications: None of the above	0.3	0.7	2.7	-0.2	0.0	1.6	0.4
Financial difficulties in last 2 years	0.6	0.8	2.2	0.1	1.0	-0.1	1.5
Mouth/teeth dental problems	0.0	0.0	0.0	-0.0	0.1	-0.0	-0.2
Heart attack	0.6	0.8	2.4	-1.5	-0.7	0.3	0.4
Allergy	2.1	4.8	8.2	0.8	-2.6	2.0	2.9
Pain all over the body in last month	0.5	0.6	1.0	0.6	0.7	1.0	0.7
Diabetes (self-reported)	0.2	0.2	0.4	0.4	0.4	0.7	-0.5
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.5	-0.3	1.9	0.1	-0.8
Medication: Ramipril	0.6	0.8	1.7	-1.3	1.1	0.2	0.3
Medication: Simvastatin	0.6	0.8	1.3	-1.0	0.9	-0.3	-1.1
Fluid intelligence score	0.5	1.0	1.6	-1.2	-0.2	1.3	0.9
Illnesses of siblings	0.0	0.0	0.1	0.0	-0.3	-0.1	0.0
Neuroticism score	0.5	1.1	2.2	-0.3	1.5	-1.2	-0.9
Weight	0.5	2.6	8.9	-0.5	3.0	-1.0	-0.3
Impedance of arm (right)	0.7	3.1	6.4	-1.1	-1.9	-1.1	-2.5
Arm fat percentage (right)	0.2	0.9	2.1	-1.2	1.5	-0.1	-0.4
Trunk fat-free mass	0.5	2.9	8.3	0.6	2.9	-1.3	1.0
Hip circumference	0.4	1.9	5.0	-1.1	2.2	-1.0	-0.5
Time employed in main current job	2.5	2.9	8.1	1.1	2.8	1.0	1.1
Alcohol intake versus 10 years previously	0.6	0.9	1.8	-0.8	1.3	1.0	0.0
Father’s age at death	0.4	0.6	1.7	-1.3	-0.8	-0.2	0.0
Worrier / anxious feelings	0.6	1.1	3.2	-0.3	1.8	-0.7	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.4	-1.2	0.3	0.1	-0.2
Falls in the last year	0.1	0.1	0.2	-0.5	0.4	-0.4	-0.1
Hair/balding pattern: Pattern 3	0.3	0.4	1.3	-1.1	-0.6	0.1	-0.4
Number of live births	0.7	1.0	1.5	-1.2	-0.9	1.2	-0.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.1	1.1	-0.5	-0.4	-0.0
Pulse rate	1.0	1.7	3.4	-1.0	1.8	-1.3	-0.8
Happiness	0.1	0.1	0.4	0.2	0.6	-0.2	0.1
Noisy workplace	0.6	0.8	2.1	0.5	0.1	0.9	1.4
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.1	-0.1	-0.2	-0.3	0.2
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	5.8	2.4	0.3	-0.4	1.1
Mouth/teeth dental problems: Dentures	0.9	1.5	2.7	0.8	-0.4	1.6	1.6
Asthma	0.7	1.4	4.8	-0.6	0.5	0.4	-2.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.1	0.9	-1.1	-0.6	0.8
Medication: Cholesterol lowering	0.5	0.8	1.5	-0.2	1.2	-0.9	-0.9
Depression (self-reported)	0.2	0.2	0.4	-0.4	0.6	0.7	-0.0
Medication: Lansoprazole	1.0	1.1	4.2	-2.0	0.0	-0.5	0.0
Prospective memory result	0.5	0.6	0.9	1.0	0.7	-0.9	-0.5
Lung cancer (father)	1.4	1.7	4.1	0.1	-1.1	2.0	1.2
Illnesses of mother	0.4	0.5	0.9	0.9	0.9	-0.5	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.5	0.7	-0.2	-0.6	0.0
Pulse wave Arterial Stiffness index	0.3	0.4	1.5	-1.2	-0.1	-0.1	-0.2
Impedance of arm (left)	0.8	3.9	6.9	-1.4	-2.5	-0.7	-2.6
Arm fat mass (right)	0.3	1.1	3.6	-0.9	1.9	-0.3	-0.1
Trunk predicted mass	0.5	2.8	7.8	0.7	2.8	-1.2	1.1
Standing height	0.3	3.1	6.7	-0.1	2.1	-2.6	-1.2
Length of working week for main job	0.4	0.5	0.6	0.7	0.7	-0.8	-0.5
Exposure to tobacco smoke at home	1.3	1.5	2.6	-1.4	-0.3	-1.1	-1.6
Breastfed as a baby	0.7	0.8	1.3	-1.0	-0.2	-0.9	-1.2
Tense / ‘highly strung’	0.6	1.0	2.2	0.0	1.5	-1.3	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.8	-0.9	0.3	-0.8	-0.4
Hair/balding pattern: Pattern 4	0.2	0.4	1.4	0.2	-1.2	0.1	0.3
Birth weight of first child	0.4	0.6	1.5	-0.7	-1.2	0.7	0.3
Peak expiratory flow (PEF)	0.3	0.8	1.9	1.4	-1.0	-0.3	0.3
Pulse wave reflection index	0.2	0.2	0.7	0.2	-0.1	0.3	0.8
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.5	0.6	-0.1	-1.2	-0.6
Loud music exposure frequency	0.9	0.9	3.0	-0.3	1.7	-0.8	0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.4	1.2	-0.0	0.3	0.7
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	6.3	-0.1	1.4	-2.5	-1.4
Blood clot in the leg (DVT)	1.4	1.9	3.5	-1.9	-0.8	-1.5	-1.0
Medication: Paracetamol	0.9	1.5	2.0	-1.4	1.3	-1.3	-0.8
Headache pain in last month	0.1	0.1	0.2	-0.4	0.3	-0.4	0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.6	-0.3	-0.8	0.2	0.5
Glaucoma (self-reported)	1.0	1.2	2.4	1.6	-0.5	0.3	1.4
Gout (self-reported)	0.1	0.1	0.2	0.2	0.3	0.4	0.0
Hypothyroidism/myxoedema (self-reported)	2.2	4.2	14.2	3.8	-0.0	1.0	1.3
Medication: Amlodipine	0.5	0.7	1.1	0.8	1.0	0.2	1.1
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.2	1.1	0.9	0.1	-0.6
Birth weight	0.2	0.5	1.7	-0.5	-1.3	-0.1	-0.3
Chronic bronchitis/emphysema (mother)	1.2	1.4	4.2	-0.6	-0.5	2.1	0.9
High blood pressure (siblings)	0.1	0.2	0.3	-0.4	-0.2	0.6	0.3
Forced vital capacity (FVC), Best measure	0.2	0.7	1.2	0.9	-1.1	0.1	0.7
Body fat percentage	0.5	2.1	3.4	-1.8	1.9	-0.6	-1.3
Leg fat percentage (right)	0.5	2.0	6.1	-1.1	2.5	-0.5	-0.5
Arm fat-free mass (right)	0.4	2.2	8.1	0.2	2.9	-0.5	0.6
Exposure to tobacco smoke outside home	0.7	1.0	2.2	-1.2	-0.1	-1.5	-0.2
Comparative body size at age 10	0.5	1.3	2.7	0.1	-0.8	1.3	1.6
Number of full brothers	0.5	0.6	1.5	0.3	0.4	1.2	0.7
Worry too long after embarrassment	1.5	2.5	4.3	-1.3	0.4	-1.9	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.9	-1.4	-0.6	0.4	0.3
Wheeze or whistling in the chest in last year	2.6	4.7	11.6	-1.5	3.4	-1.5	-1.6
Number of children fathered	1.9	2.1	2.9	-1.7	-0.8	-1.5	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.9	-0.9	-0.1	-0.3	-1.0
Age at first live birth	0.7	1.3	2.5	-1.1	1.6	-0.9	-0.9
Pulse wave peak to peak time	0.4	0.5	1.6	1.3	-0.1	0.3	0.4
Health satisfaction	0.5	0.6	1.5	-1.2	0.1	-0.1	-1.0
Shortness of breath walking on level ground	0.9	1.0	2.8	-1.7	-0.3	-0.6	-0.9
Qualifications: College or University degree	0.6	1.8	3.5	-0.8	0.5	-1.7	-1.9
Eye problems/disorders: None of the above	1.5	1.7	3.7	-0.0	1.9	1.0	1.5
Mouth/teeth dental problems: Loose teeth	1.3	1.5	3.6	-1.9	0.7	-1.3	-0.6
Emphysema/chronic bronchitis	2.2	2.4	3.3	-1.8	1.8	-1.2	-1.3
Medication for pain relief, constipation, heartburn	0.3	0.5	1.0	1.0	-0.2	1.0	0.3
Neck or shoulder pain in last month	0.4	0.6	1.3	0.8	-0.5	1.1	0.5
Medication: Blood pressure	0.3	0.4	1.5	0.2	1.2	0.5	0.0
Angina (self-reported)	0.7	0.9	2.5	-1.6	0.1	-0.7	-0.8
Migraine (self-reported)	1.7	2.1	4.7	-1.1	0.7	-2.2	-1.5
Medication: Ibuprofen	0.8	0.9	2.3	1.1	-0.5	-1.5	-0.1
Medication: Allopurinol	1.2	1.6	3.9	1.2	0.9	2.0	0.7
Medication: Omeprazole	0.9	1.1	2.6	-1.3	-0.0	1.6	-0.2
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.5	0.0	-0.1	0.3
Mean time to correctly identify matches	0.5	1.0	2.3	-0.9	-1.5	-0.9	-0.5
Heart disease (mother)	0.2	0.2	0.7	-0.8	0.0	0.3	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.0	1.0	0.8	0.8	0.5
Whole body fat mass	0.7	2.9	7.8	-1.4	2.8	-1.0	-1.0
Leg fat mass (right)	0.6	2.5	9.1	-0.7	3.0	-0.6	-0.3
Arm predicted mass (right)	0.5	2.3	8.2	0.2	2.9	-0.8	0.6
Pulse rate, automated reading	0.1	0.4	0.8	-0.7	0.5	0.5	0.9
Alcohol intake frequency.	0.4	0.9	3.3	-0.2	1.8	0.2	0.6
Comparative height size at age 10	0.5	2.8	8.6	0.2	2.9	-1.6	0.2
Number of full sisters	0.4	0.5	1.3	-0.7	-1.1	-0.6	-0.0
Suffer from ‘nerves’	3.1	4.8	5.9	-2.2	2.3	-2.4	-1.8
Overall health rating	0.4	0.8	2.8	-0.3	1.7	0.5	-0.1
Chest pain or discomfort	0.6	0.8	1.6	-0.8	1.0	-0.2	1.3
Had major operations	1.3	1.5	2.5	0.4	-1.4	1.2	1.6
Age at last live birth	0.2	0.4	0.7	-0.2	0.8	-0.7	-0.5
Family relationship satisfaction	4.3	5.3	8.3	0.8	-2.9	2.6	2.4
Leg pain on walking	0.3	0.3	1.2	0.2	0.3	-1.1	-0.1
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.3	0.2	-0.5	1.8	1.1
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.8	-0.4	0.9	-0.5	-0.9
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.6	-0.6	-0.3	-0.3	-0.8
Medication: Aspirin	0.4	0.6	1.2	-1.1	-1.1	0.2	-0.1
Supplements: Vitamin C	2.0	2.4	5.4	-1.3	0.8	-2.3	-1.4
Knee pain experienced in last month	0.4	0.7	1.2	-0.1	0.8	-1.1	-1.0
Hypertension (Self-reported)	0.2	0.6	1.3	-0.8	1.1	0.0	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.8	-0.9	0.8	-0.0	0.0
Illnesses of father: Heart disease	0.6	0.8	2.4	-0.5	1.5	-0.7	0.3
Illnesses of siblings: Diabetes	0.9	1.1	4.2	2.0	0.4	-0.2	0.0
Smoking status: Previous	1.1	1.7	4.2	-0.6	-2.0	0.9	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	3.4	0.4	0.7	-1.9	-1.0
Whole body fat-free mass	0.4	2.5	7.7	0.6	2.8	-1.0	0.9
Leg fat-free mass (right)	0.4	1.9	5.8	0.7	2.4	-0.9	0.7
Arm fat percentage (left)	0.2	0.8	1.8	-1.2	1.3	0.0	-0.4
Average weekly red wine intake	0.9	1.3	3.6	1.9	-0.1	0.7	1.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.5	1.2	-0.2	-0.2	-0.6
Mood swings	0.0	0.1	0.2	-0.2	-0.5	0.1	-0.2
Loneliness, isolation	2.0	2.8	4.5	0.7	1.9	1.7	2.1
Long-standing illness, disability or infirmity	1.2	1.9	4.8	-1.3	2.2	-0.9	-0.5
Ever had bowel cancer screening	2.2	2.5	4.5	-1.4	2.1	-1.5	-1.2
Diabetes diagnosed by doctor	0.4	0.6	1.5	0.8	1.2	0.1	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.0	-1.4	-1.2	-0.6	-0.1
Friendships satisfaction	0.8	1.0	3.0	-0.8	-1.7	0.5	-0.5
Qualifications: nursing, teaching	0.4	0.7	1.4	0.1	1.2	1.0	0.6
Commuting to job workplace: Walk	0.3	0.3	0.7	0.1	-0.1	0.9	0.7
Eye problems/disorders: Cataract	1.3	1.5	5.9	0.1	-2.4	0.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.1	0.5	-1.0	0.8	0.7
Medication for cholesterol	0.9	1.3	2.2	1.3	-0.6	1.0	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.0	-0.9	0.8	-1.4	-0.4
Back pain experienced in last month	0.2	0.3	0.8	-0.6	-0.9	-0.1	0.3
Mineral and other dietary supplements	1.7	2.3	4.9	0.8	-1.9	2.2	0.3
Breast cancer (self-reported)	0.5	0.6	1.1	-0.5	1.1	-0.9	0.4
Asthma (self-reported)	0.8	1.6	4.7	-0.8	0.3	0.9	-2.2
Osteoporosis (self-reported)	1.0	1.3	2.7	-0.7	-0.2	-1.6	-1.4
Osteoarthritis (self-reported)	1.0	1.3	2.8	0.5	1.2	0.9	1.7
Medication: Aspirin	0.3	0.4	0.9	-0.9	-0.8	0.1	0.0
Medication: Gliclazide	0.3	0.3	0.9	1.0	0.6	0.1	0.1
Illnesses of father: None of the above (group 1)	0.7	0.9	2.7	-0.0	-1.6	0.9	-0.2
Smoking status: Current	0.6	0.9	1.6	1.1	-0.3	0.9	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	0.8	0.9	-0.8	0.8	0.4
Whole body water mass	0.4	2.2	6.8	0.6	2.6	-1.0	0.9
Leg predicted mass (right)	0.4	1.9	5.8	0.6	2.4	-0.9	0.7
Arm fat mass (left)	0.2	0.9	2.6	-1.1	1.6	-0.1	-0.1
Number of self-reported non-cancer illnesses	0.5	0.9	2.3	-0.1	1.1	1.5	-0.2
Average weekly champagne plus white wine intake	2.0	2.8	7.9	-2.8	-1.7	-0.6	-0.5
Miserableness	0.3	0.6	0.9	0.9	-0.2	1.0	0.6
Guilty feelings	0.1	0.1	0.5	0.2	0.0	0.2	0.7
Wears glasses or contact lenses	0.2	0.2	0.3	-0.6	-0.5	-0.3	0.0
Ever taken oral contraceptive pill	1.8	2.0	6.8	-1.0	-2.6	0.1	-0.2
Hearing aid user	2.0	2.2	4.4	1.5	0.7	1.3	2.1
Mother’s age at death	0.8	1.0	1.7	-0.6	1.3	1.3	0.7
Financial situation satisfaction	0.5	0.7	1.5	-0.4	-1.2	0.5	0.8
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.5	-0.1	1.2	0.2	0.0
Commuting to job workplace: Public transport	0.5	0.7	2.2	0.5	-1.5	-0.2	0.3
Eye problems/disorders: Glaucoma	0.3	0.4	0.6	0.7	-0.6	-0.3	0.7
Medication: Blood pressure	1.1	2.1	3.2	-1.3	1.8	-1.2	-1.5
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.4	0.4	1.1	0.9	1.2
Supplements: Fish oil (including cod liver oil)	2.0	2.5	6.0	-1.2	2.4	-1.7	-0.1
High cholesterol (Self-reported)	1.5	2.7	4.5	-2.1	1.1	-0.9	-2.1
Medication: Bendroflumethiazide	1.7	2.6	4.2	0.6	1.8	-1.7	-2.1
Medication: Paracetamol	0.8	1.2	1.9	-1.0	1.4	-1.3	-0.5
Medication: Lisinopril	1.0	1.4	4.5	0.7	2.1	-0.2	-0.6
Medication: Atorvastatin	0.8	1.0	1.8	-0.9	1.0	-0.8	-1.4
Illnesses of father: High blood pressure	0.5	0.6	1.5	-0.0	1.2	-0.4	-0.9
Alcohol drinker status: Never	0.6	0.8	1.8	0.6	1.3	-0.3	0.9
Ever smoked	1.7	3.0	7.8	-0.4	-2.8	1.4	1.4
Basal metabolic rate	0.5	2.5	8.4	0.2	2.9	-1.2	0.5
Leg fat percentage (left)	0.5	2.0	6.4	-1.1	2.5	-0.5	-0.4
Arm fat-free mass (left)	0.5	2.4	8.2	0.2	2.9	-0.9	0.7
Number of operations (self-reported)	0.9	1.4	3.6	-1.9	-0.9	0.8	0.8
Average weekly beer plus cider intake	0.9	1.3	4.4	-2.1	0.5	-0.5	-0.5
Irritability	0.5	0.9	1.6	1.2	-1.0	0.9	0.6
Risk taking	0.1	0.1	0.2	0.3	-0.3	0.3	0.5
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.0	0.4	-1.0	0.2	1.0
Fractured/broken bones in last 5 years	4.2	5.5	7.5	-1.6	2.1	-2.7	-2.7
Age started oral contraceptive pill	0.3	0.4	1.0	-0.0	1.0	0.7	-0.4
Diastolic blood pressure, automated reading	0.3	0.9	3.1	-0.3	1.8	-0.4	0.6
Ever depressed for a whole week	0.9	1.2	3.2	0.3	-1.8	-0.8	-0.8
Unable to work because of sickness or disability	2.4	3.1	6.6	-2.0	2.6	-0.6	-1.2
Commuting to job workplace: Cycle	0.6	0.7	1.4	-1.2	-1.1	-0.3	-0.4
Myopia	0.3	0.4	0.9	-0.4	0.8	1.0	-0.1
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.6	0.8	-0.8	-0.2	0.6
Cholesterol lowering medication	1.2	1.8	4.0	-2.0	0.6	1.0	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	3.3	-0.4	-0.3	1.8	0.3
Pain experienced in last month	0.1	0.2	0.5	0.7	0.1	-0.1	-0.5
Supplements: Calcium	0.5	0.5	1.7	-1.3	-0.1	-0.6	-0.2
Basal cell carcinoma (self-reported)	0.4	0.5	1.6	-1.3	-0.5	-0.2	-0.4
Heart attack/myocardial infarction (self-reported)	0.6	0.8	3.0	-1.7	-0.2	0.2	0.2
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.5	-1.6	-0.9	-1.1	-0.8
Heart disease (siblings)	0.8	1.0	2.0	-1.4	0.9	-0.5	-1.0
Alcohol drinker status: Previous	0.6	0.7	1.0	-0.8	1.0	-0.8	0.6
Pack years of smoking	0.9	1.3	3.2	0.4	1.8	-1.0	0.9
Impedance of whole body	1.1	5.4	10.8	-2.2	-1.8	-1.6	-3.3
Leg fat mass (left)	0.7	2.7	9.5	-0.9	3.1	-0.7	-0.4
Arm predicted mass (left)	0.5	2.8	9.2	-0.0	3.0	-1.2	0.6