Best TWAS P=1.23e-22 · Best GWAS P=1.05e-22 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LRRC34 | 0.08 | 0.09 | lasso | 3 | 0.08 | 4.5e-10 | 6.8 | -6.6 | 4.2e-11 | -0.61 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | LRRC34 | 0.08 | 0.07 | lasso | 6 | 0.06 | 1.1e-05 | 6.1 | -6.7 | 2.1e-11 | -0.65 | 0.48 | 0.50 | FALSE |
| 3 | GTEx | Adrenal Gland | LRRC34 | 0.23 | 0.08 | lasso | 7 | 0.09 | 4.4e-04 | 6.7 | -6.6 | 4.4e-11 | -0.59 | 0.24 | 0.20 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | LRRC34 | 0.14 | 0.09 | lasso | 5 | 0.10 | 9.6e-08 | 3.7 | -6.0 | 2.5e-09 | -0.68 | 0.37 | 0.62 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | RP11-362K14.6 | 0.08 | 0.00 | lasso | 3 | 0.00 | 1.5e-01 | 8.4 | -8.2 | 1.9e-16 | -0.85 | 0.07 | 0.70 | FALSE |
| 6 | GTEx | Nerve Tibial | LRRC34 | 0.18 | 0.11 | lasso | 7 | 0.10 | 1.8e-07 | 6.0 | -7.5 | 6.1e-14 | -0.75 | 0.67 | 0.32 | FALSE |
| 7 | GTEx | Testis | MYNN | 0.12 | 0.13 | lasso | 5 | 0.13 | 1.8e-06 | 9.8 | 9.8 | 1.2e-22 | 1.00 | 0.01 | 0.99 | TRUE |
| 8 | GTEx | Testis | RP11-362K14.5 | 0.12 | 0.16 | lasso | 3 | 0.14 | 1.0e-06 | 9.8 | 9.8 | 1.4e-22 | 1.00 | 0.01 | 0.99 | FALSE |
| 9 | GTEx | Whole Blood | GPR160 | 0.18 | 0.16 | enet | 17 | 0.18 | 6.6e-16 | -5.0 | -5.5 | 4.5e-08 | -0.12 | 1.00 | 0.00 | FALSE |
| 10 | YFS | Blood | GPR160 | 0.20 | 0.20 | enet | 25 | 0.27 | 1.1e-89 | -4.2 | -5.8 | 6.7e-09 | -0.21 | 1.00 | 0.00 | TRUE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PHC3 | 0.04 | 0.01 | lasso | 5 | 0.01 | 9.7e-03 | -5.3 | 5.6 | 2.2e-08 | 0.11 | 0.01 | 0.91 | FALSE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ARPM1 | 0.04 | 0.02 | blup | 27 | 0.02 | 3.4e-03 | 9.4 | -9.0 | 1.7e-19 | -0.91 | 0.04 | 0.85 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ARPM1 | 0.02 | 0.04 | lasso | 1 | 0.04 | 6.9e-05 | 9.6 | -9.6 | 5.2e-22 | -0.97 | 0.02 | 0.92 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LRRC34 | 0.10 | 0.08 | lasso | 5 | 0.08 | 8.9e-10 | 6.8 | -6.9 | 4.9e-12 | -0.71 | 0.91 | 0.09 | FALSE |
| 15 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LRRIQ4 | 0.06 | 0.07 | lasso | 3 | 0.12 | 2.4e-05 | 3.7 | 7.4 | 1.5e-13 | 0.81 | 0.02 | 0.89 | FALSE |