Best TWAS P=1.1e-11 · Best GWAS P=7.84e-34 conditioned to 1.92e-24
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | ARHGEF16 | 0.28 | 0.17 | lasso | 3 | 0.20 | 3.0e-13 | 5.3 | 5.5 | 4.6e-08 | 0.25 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Esophagus Muscularis | RP3-395M20.12 | 0.08 | 0.06 | enet | 6 | 0.06 | 2.3e-04 | 3.1 | -5.4 | 6.9e-08 | 0.00 | 0.08 | 0.82 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | ARHGEF16 | 0.22 | 0.08 | lasso | 8 | 0.09 | 6.7e-08 | 5.1 | 6.8 | 1.1e-11 | 0.31 | 0.99 | 0.01 | TRUE |
| 4 | GTEx | Spleen | RP3-395M20.9 | 0.42 | 0.14 | lasso | 3 | 0.15 | 1.1e-04 | -5.3 | -5.5 | 3.3e-08 | -0.06 | 0.03 | 0.77 | TRUE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | ARHGEF16 | 0.19 | 0.14 | lasso | 8 | 0.17 | 2.0e-21 | 4.0 | 6.1 | 1.1e-09 | 0.28 | 1.00 | 0.00 | FALSE |