[Hub]/) : Traits : Lung FEV1/FVC ratio : →

chr1:1,781,220-4,040,155

Best TWAS P=1.1e-11 · Best GWAS P=7.84e-34 conditioned to 1.92e-24

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Skin Sun Exposed Lower leg	ARHGEF16	0.22	0.08	lasso	8	0.09	6.7e-08	5.1	6.8	1.1e-11	0.31	0.99	0.01	TRUE
4	GTEx	Spleen	RP3-395M20.9	0.42	0.14	lasso	3	0.15	1.1e-04	-5.3	-5.5	3.3e-08	-0.06	0.03	0.77	TRUE
5	ROSMAP	Brain Pre-frontal Cortex	ARHGEF16	0.19	0.14	lasso	8	0.17	2.0e-21	4.0	6.1	1.1e-09	0.28	1.00	0.00	FALSE
1	GTEx	Esophagus Mucosa	ARHGEF16	0.28	0.17	lasso	3	0.20	3.0e-13	5.3	5.5	4.6e-08	0.25	1.00	0.00	FALSE
2	GTEx	Esophagus Muscularis	RP3-395M20.12	0.08	0.06	enet	6	0.06	2.3e-04	3.1	-5.4	6.9e-08	0.00	0.08	0.82	FALSE