TWAS hub - ARHGEF16

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.280	0.0560	6.6e-08	0.170	NA	0.178	NA	0.197	1.8e-11	NA	5.6e-12	NA	3.0e-13
2	GTEx	Nerve Tibial	0.207	0.0518	1.5e-05	0.089	NA	0.051	NA	0.084	6.9e-07	NA	1.5e-04	NA	1.6e-06
3	GTEx	Skin Sun Exposed Lower leg	0.220	0.0450	8.8e-09	0.077	NA	0.081	NA	0.090	6.4e-07	NA	3.0e-07	NA	6.6e-08
4	GTEx	Testis	0.261	0.0730	2.2e-04	0.206	NA	0.241	NA	0.244	1.6e-09	NA	4.5e-11	NA	3.6e-11
5	ROSMAP	Brain Pre-frontal Cortex	0.190	0.0316	5.2e-15	0.137	0.153	0.164	0.169	0.171	3.1e-17	3.9e-19	1.6e-20	3.8e-21	2.0e-21
6	TCGA	Brain Lower Grade Glioma	0.025	0.0153	6.4e-03	0.002	-0.001	-0.002	NA	0.020	1.8e-01	4.7e-01	5.5e-01	NA	2.2e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Tinnitus: Yes, but not now, but have in the past	14.8	15.8	16.5	-3.9	-3.9	-4.1	4.0	-3.9	-4.0
Lung FEV1/FVC ratio	5.9	30.1	46.1	5.5	4.0	6.8	-5.1	6.1	5.0
Wears glasses or contact lenses	5.3	6.1	7.0	2.5	2.2	2.5	-2.6	2.5	2.6
Chronotype (morning person)	4.8	11.2	14.0	3.7	3.2	3.7	-3.3	2.9	3.2
Migraine (self-reported)	4.5	5.5	6.9	2.5	1.7	2.4	-2.6	2.3	2.6
Guilty feelings	4.5	6.7	8.0	-2.5	-2.2	-2.7	2.8	-2.5	-2.8
Alcohol drinker status: Previous	4.5	5.2	7.3	-1.9	-1.9	-2.6	2.3	-2.7	-2.1
Forced vital capacity (FVC)	3.6	14.0	16.1	-3.5	-3.7	-3.7	3.9	-3.6	-4.0
Ever taken oral contraceptive pill	3.6	4.0	5.1	-2.1	-1.6	-2.1	2.2	-1.6	-2.2
Ulcerative Colitis	3.3	4.9	6.0	-2.4	-2.3	-1.6	2.5	-1.8	-2.4
Fractured/broken bones in last 5 years	3.2	4.1	8.0	-2.0	-2.8	-1.8	1.6	-2.2	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.9	3.4	4.9	-1.9	-1.8	-1.6	2.2	-1.3	-2.2
Prospective memory result	2.8	3.4	4.8	-1.7	-1.7	-1.9	1.7	-2.2	-1.8
Eye problems/disorders: None of the above	2.8	3.2	5.2	-1.8	-1.3	-2.3	1.7	-2.0	-1.6
Asthma	2.7	5.3	9.5	-2.1	-2.0	-2.4	2.1	-3.1	-1.9
Forced vital capacity (FVC), Best measure	2.7	10.0	11.5	-2.9	-3.2	-3.1	3.2	-3.1	-3.4
Neuroticism	2.6	6.2	7.4	-2.3	-2.7	-2.4	2.6	-2.4	-2.5
Pulse wave peak to peak time	2.6	3.1	4.0	1.7	2.0	1.6	-1.9	1.6	1.8
Qualifications: NVQ or HND or HNC or equivalent	2.6	3.1	4.7	-1.6	-1.7	-2.2	1.7	-1.6	-1.7
Long-standing illness, disability or infirmity	2.6	3.9	6.1	-1.9	-1.6	-2.1	1.9	-2.5	-1.8
Pulse wave Arterial Stiffness index	2.5	2.9	3.9	-1.6	-2.0	-1.5	1.8	-1.6	-1.7
Pulse wave reflection index	2.5	3.1	4.5	-1.7	-1.9	-1.2	2.0	-1.4	-2.1
Asthma (self-reported)	2.3	4.7	8.6	-1.9	-1.9	-2.4	1.9	-2.9	-1.7
Neck or shoulder pain in last month	2.2	3.2	4.4	-1.8	-1.7	-2.1	1.6	-1.9	-1.5
Bipolar Disorder (2018)	2.0	3.2	3.9	-1.8	-1.6	-1.6	1.8	-2.0	-1.8
Lung FVC	2.0	10.1	11.8	-2.9	-3.0	-3.4	3.1	-3.4	-3.2
Medication: Levothyroxine sodium	2.0	3.4	4.5	-1.8	-1.6	-1.8	2.1	-1.7	-2.0
Mouth/teeth dental problems: Dentures	2.0	3.4	4.4	1.8	2.1	1.5	-1.9	1.9	1.8
Leg pain on walking	2.0	2.5	3.6	-1.4	-1.5	-1.9	1.7	-1.5	-1.4
Fed-up feelings	1.9	3.4	4.2	-1.7	-1.4	-2.0	2.0	-1.8	-2.0
Eye problems/disorders: Cataract	1.9	2.2	3.1	1.6	1.4	1.8	-1.5	1.1	1.4
Risk taking	1.9	2.8	5.0	-1.5	-1.1	-2.2	1.6	-1.9	-1.5
Neuroticism (2016)	1.7	2.5	3.5	-1.5	-1.3	-1.5	1.6	-1.6	-1.9
Respiratory disease	1.7	3.9	7.1	-1.8	-1.4	-2.3	1.8	-2.7	-1.5
Neuroticism score	1.7	3.6	4.3	-1.7	-1.7	-1.9	2.1	-2.0	-2.0
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	4.3	-1.9	-1.4	-1.6	1.5	-2.1	-1.3
Osteoporosis (self-reported)	1.7	2.2	3.0	-1.6	-1.2	-1.6	1.3	-1.7	-1.3
Ulcerative Colitis (UC)	1.6	3.1	4.2	-1.9	-2.0	-0.9	1.9	-1.6	-1.9
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	5.2	-1.1	-0.4	-2.3	1.2	-1.7	-1.0
Myopia	1.6	2.3	3.2	1.4	1.3	1.8	-1.4	1.8	1.3
Sitting height	1.5	10.9	15.0	-3.1	-3.9	-2.7	3.4	-3.2	-3.4
Allergy	1.5	3.5	6.7	1.5	1.4	2.2	-1.7	2.6	1.6
Family relationship satisfaction	1.5	1.9	2.6	-1.5	-1.4	-0.8	1.6	-1.4	-1.5
Gout (self-reported)	1.4	1.9	3.7	1.3	1.9	0.6	-1.3	1.5	1.3
Medication: Aspirin	1.4	1.8	2.7	-1.4	-0.8	-1.6	1.6	-0.9	-1.5
Intelligence (Savage-Jansen 2018)	1.3	4.1	6.4	2.0	1.4	2.5	-1.9	2.0	2.1
Cardiovascular Disease	1.3	4.2	4.8	2.0	1.9	2.0	-2.1	2.1	2.2
Number of treatments/medications taken	1.3	2.3	3.8	-1.4	-1.1	-2.0	1.6	-1.6	-1.5
Townsend deprivation index at recruitment	1.3	1.9	2.6	-1.1	-1.0	-1.4	1.6	-1.3	-1.6
Chronic bronchitis/emphysema (mother)	1.3	1.5	2.1	-1.3	-1.3	-1.2	1.1	-1.4	-1.0
High blood pressure (siblings)	1.3	1.9	3.1	1.3	1.8	1.0	-1.3	1.4	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	2.5	-1.6	-0.9	-1.0	1.2	-1.4	-1.1
High cholesterol (Self-reported)	1.3	2.2	2.6	1.5	1.3	1.5	-1.6	1.5	1.6
Schizophrenia (2018)	1.2	2.4	5.1	1.8	2.2	0.8	-1.5	1.3	1.2
Irritable Bowel Disease (IBD)	1.2	3.0	4.2	-1.8	-2.1	-1.1	1.6	-1.9	-1.7
Fasting Glucose	1.2	1.4	2.2	-1.2	-1.0	-1.4	1.3	-0.5	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	3.3	-1.8	-1.7	-1.5	1.6	-1.4	-1.7
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	1.9	-1.2	-1.4	-1.2	1.0	-1.2	-0.9
Loud music exposure frequency	1.2	1.3	1.8	-1.2	-1.1	-1.3	1.2	-0.9	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	2.2	-1.3	-1.3	-1.0	1.3	-1.5	-1.1
Relative age of first facial hair	1.1	2.2	3.3	1.5	1.2	1.8	-1.3	1.8	1.2
Taking other prescription medications	1.1	1.6	1.9	-1.3	-1.0	-1.4	1.4	-1.3	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.6	2.9	-1.7	-1.4	-1.4	1.7	-1.7	-1.7
Hayfever, allergic rhinitis or eczema	1.1	2.3	3.6	-1.4	-1.6	-1.4	1.4	-1.9	-1.4
Medication: Allopurinol	1.1	1.4	3.2	1.2	1.8	0.4	-1.0	1.2	1.0
Arm fat percentage (left)	1.1	4.3	4.9	2.2	2.2	2.2	-2.2	1.6	2.0
Mood swings	1.1	1.9	3.2	-1.1	-1.0	-1.8	1.5	-1.2	-1.5
Smoking status: Current	1.1	1.7	2.9	-1.4	-1.7	-0.6	1.3	-1.2	-1.4
Average weekly beer plus cider intake	1.1	1.7	2.5	-1.2	-0.3	-1.6	1.4	-1.4	-1.4
Pain experienced in last month	1.1	1.9	2.9	1.1	0.7	1.7	-1.6	1.3	1.6
Depressed Affect (Nagel 2018)	1.0	2.2	2.8	-1.4	-1.0	-1.5	1.6	-1.7	-1.6
Type 2 Diabetes (T2D) (2012)	1.0	1.1	1.9	-1.3	-0.3	-1.4	1.2	-1.4	0.0
Severe depression (siblings)	1.0	1.1	2.1	-1.0	-1.4	-1.0	0.5	-1.5	-0.6
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	1.8	-1.1	-0.8	-1.0	1.1	-0.9	-1.3
Arm fat percentage (right)	1.0	3.8	4.4	2.1	2.1	2.0	-2.1	1.5	1.9
Number of children fathered	1.0	1.1	1.9	1.2	1.4	0.9	-1.0	1.1	0.8
Alcohol intake frequency.	1.0	2.3	3.2	-1.3	-1.6	-1.4	1.4	-1.8	-1.5
Average weekly red wine intake	1.0	1.5	2.5	-1.2	-1.0	-1.6	1.2	-1.1	-1.3
Hearing difficulty/problems: Yes	0.9	1.4	1.9	1.1	1.2	0.9	-1.2	1.1	1.4
Relative age voice broke	0.9	1.5	2.6	1.2	0.9	1.6	-1.0	1.4	0.9
Medication: Simvastatin	0.9	1.3	1.6	1.1	1.1	1.3	-1.2	0.9	1.1
Worrier / anxious feelings	0.9	1.7	1.9	-1.1	-1.3	-1.4	1.4	-1.1	-1.4
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	2.1	-1.3	-1.5	-1.0	1.4	-1.4	-1.4
Wheeze or whistling in the chest in last year	0.9	1.7	3.1	-1.3	-0.9	-1.4	1.1	-1.8	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.0	1.1	0.0	1.4	-1.1	0.8	1.1
Chest pain or discomfort	0.9	1.3	3.3	-0.8	-0.1	-1.8	0.9	-1.5	-0.8
Neuroticism (Nagel 2018)	0.8	1.8	2.2	-1.2	-1.3	-1.4	1.4	-1.5	-1.3
Hand grip strength (left)	0.8	2.0	2.6	1.5	1.6	1.6	-1.1	1.6	1.1
Medication: Co-codamol	0.8	0.9	1.5	-1.1	-0.7	-1.2	0.9	-0.8	-0.9
Medication: Metformin	0.8	1.1	2.0	-1.2	-0.8	-0.7	1.1	-1.4	-1.1
Current tobacco smoking	0.8	1.3	2.5	-1.2	-1.6	-0.4	1.2	-1.1	-1.2
Qualifications: CSEs or equivalent	0.8	1.1	2.2	-1.1	-0.5	-1.5	0.9	-1.0	-1.0
Medication: Atenolol	0.8	1.0	1.2	-0.8	-0.9	-1.0	1.1	-1.0	-1.1
Illnesses of mother	0.8	0.9	1.4	1.1	1.0	1.0	-0.8	1.2	0.6
Exposure to tobacco smoke at home	0.8	0.9	1.3	-1.1	-0.9	-0.7	1.1	-0.8	-0.8
Medication: Seretide 50 evohaler	0.8	0.9	1.6	-0.9	-0.2	-1.3	0.9	-1.2	-0.8
Suffer from ‘nerves’	0.8	1.3	2.0	-1.0	-1.4	-1.1	1.0	-1.1	-1.0
Supplements: Vitamin C	0.8	1.0	1.1	-1.1	-1.0	-0.9	1.1	-0.8	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	1.9	-1.2	-0.6	-1.4	1.1	-1.3	-0.9
Illnesses of father: High blood pressure	0.8	1.0	2.2	1.0	1.5	0.2	-0.9	0.7	1.1
Depression (Nagel 2018)	0.7	1.1	2.5	-1.0	-0.1	-1.6	0.9	-1.2	-1.0
Blood Eosinophil Count	0.7	5.7	12.0	-2.4	-2.6	-1.5	2.0	-3.5	-1.8
Ever had hysterectomy (womb removed)	0.7	0.8	1.3	-0.8	-0.6	-1.1	0.8	-1.1	-0.8
Number of incorrect matches in round	0.7	1.2	1.9	-1.1	-1.4	-0.4	1.2	-0.9	-1.2
Qualifications: None of the above	0.7	1.6	2.9	1.4	1.7	1.1	-0.9	1.4	0.8
Standing height	0.7	6.6	7.7	-2.5	-2.8	-1.8	2.8	-2.6	-2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	1.4	-1.1	-0.8	-1.2	0.9	-1.1	-0.8
Emphysema/chronic bronchitis	0.7	0.8	2.3	-0.8	-0.1	-0.9	0.8	-1.5	-0.6
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.6	0.9	0.3	1.3	-1.1	0.8	1.1
Supplements: Calcium	0.7	0.8	1.5	0.9	0.4	0.9	-1.1	0.5	1.2
Prostate Cancer	0.6	0.9	1.6	0.9	0.7	1.3	-0.7	1.2	0.5
HDL Cholesterol	0.6	1.0	1.4	-1.0	-1.1	-1.1	0.9	-1.2	0.0
Lupus	0.6	0.9	1.6	0.7	1.0	0.5	-1.2	0.7	1.3
Smoking Status	0.6	1.4	3.4	-1.3	-1.8	-0.7	0.9	-1.3	-0.8
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.2	-0.9	-0.5	-1.0	1.0	-1.1	-1.0
Qualifications: A levels/AS levels or equivalent	0.6	1.4	3.2	-1.4	-0.8	-1.2	0.8	-1.8	-0.7
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.7	-0.8	-0.4	-1.1	0.7	-1.3	-0.7
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.6	-0.7	-0.6	-1.3	0.7	-1.3	-0.6
Body fat percentage	0.6	2.4	3.0	1.7	1.7	1.7	-1.5	1.1	1.3
Mouth/teeth dental problems: Loose teeth	0.6	0.8	1.2	0.9	0.4	0.9	-1.0	0.6	1.1
Comparative height size at age 10	0.6	3.1	4.5	-1.6	-1.2	-1.7	2.0	-1.7	-2.1
Miserableness	0.6	1.0	1.5	-0.8	-0.7	-1.2	1.2	-0.8	-1.2
Hearing aid user	0.6	0.6	0.8	-0.9	-0.7	-0.9	0.9	-0.5	-0.9
Irritability	0.6	1.0	3.0	-0.8	-0.8	-1.7	1.0	-0.5	-0.9
Schizophrenia vs Biploar Disorder	0.5	0.6	1.2	1.1	0.8	0.7	-0.9	0.8	0.0
Allergy or Eczema	0.5	1.3	2.5	-1.0	-1.6	-0.9	1.0	-1.4	-0.9
Sensitivity / hurt feelings	0.5	0.8	1.5	-0.7	-0.9	-1.1	0.6	-1.2	-0.6
Systolic blood pressure, automated reading	0.5	1.6	2.2	1.4	1.2	0.8	-1.4	1.1	1.5
Trunk fat percentage	0.5	2.1	2.8	1.6	1.7	1.7	-1.4	1.1	1.2
Hair/balding pattern: Pattern 3	0.5	0.8	1.6	0.7	0.6	1.2	-1.0	0.4	1.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	2.9	-1.0	-1.5	-0.8	1.5	-0.9	-1.7
Leg fat percentage (right)	0.5	1.9	2.6	1.6	1.4	1.5	-1.5	0.8	1.3
Heart disease (mother)	0.5	0.7	1.2	-0.8	-0.5	-1.1	0.8	-0.8	-0.8
Number of full sisters	0.5	0.6	1.2	-0.7	-0.0	-1.1	0.8	-1.0	-0.7
Age at last live birth	0.5	0.7	1.1	-0.9	-0.7	-1.0	0.7	-0.9	-0.6
Loneliness, isolation	0.5	0.6	0.9	-0.8	-0.5	-0.5	0.9	-1.0	-0.9
Medication: Aspirin	0.5	0.7	1.2	-0.9	-0.5	-1.1	0.9	-0.6	-0.8
Number of self-reported non-cancer illnesses	0.5	0.9	2.0	-0.7	-0.7	-1.2	0.7	-1.4	-0.7
Pack years of smoking	0.5	0.8	1.2	1.0	0.8	0.8	-0.8	1.1	0.8
Worry (Nagel 2018)	0.4	0.9	1.1	-0.8	-1.1	-1.0	0.9	-1.1	-0.8
Alzheimer’s Disease (in father)	0.4	0.4	0.8	0.5	0.9	0.8	-0.5	0.3	0.6
Hypothyroidism (self reported)	0.4	0.9	1.3	-0.8	-1.1	-0.8	0.9	-1.1	-0.8
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.5	0.1	-0.3	1.2	-0.1	0.9	0.2
Diabetes (father)	0.4	0.5	1.3	0.6	1.2	0.4	-0.4	0.7	0.4
Pack years adult smoking proportion	0.4	0.7	1.0	0.9	0.8	0.6	-0.7	1.0	0.7
Hand grip strength (right)	0.4	1.2	2.6	1.2	0.9	1.6	-0.7	1.1	0.7
Maternal smoking around birth	0.4	0.6	1.8	0.6	1.3	0.7	-0.6	0.7	0.6
Serious illness, injury or assault to yourself	0.4	0.5	0.7	0.8	0.7	0.2	-0.7	0.8	0.7
Body mass index (BMI)	0.4	1.5	2.1	1.4	1.4	1.1	-1.4	0.8	1.2
Fluid intelligence score	0.4	0.8	1.2	1.0	0.2	1.1	-0.9	0.8	0.9
Father’s age at death	0.4	0.6	1.3	0.8	0.2	1.1	-0.8	0.7	0.7
Happiness	0.4	0.4	0.9	0.6	0.1	0.9	-0.5	0.8	0.6
Noisy workplace	0.4	0.5	1.5	0.6	1.2	0.3	-0.5	0.5	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	2.3	-0.8	-1.5	-1.0	1.3	-0.8	-1.5
Arm fat mass (right)	0.4	1.6	2.1	1.4	1.3	1.4	-1.4	0.7	1.1
Qualifications: College or University degree	0.4	1.3	1.7	1.2	1.1	1.0	-1.3	1.1	1.2
Medication for pain relief, constipation, heartburn	0.4	0.7	1.1	0.7	0.9	0.8	-1.1	0.6	0.9
Mean time to correctly identify matches	0.4	0.8	1.3	0.8	0.8	0.5	-1.0	0.8	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.0	-0.7	-1.0	-0.7	0.4	-1.0	-0.2
Hypertension (Self-reported)	0.4	1.1	1.5	1.0	1.1	0.7	-1.1	1.0	1.2
Back pain experienced in last month	0.4	0.6	1.5	-0.8	-0.2	-1.2	0.7	-0.4	-0.7
Mineral and other dietary supplements	0.4	0.5	0.9	-0.6	-0.2	-0.9	0.9	-0.5	-0.8
Illnesses of father: None of the above (group 1)	0.4	0.5	1.4	-0.6	-1.2	-0.1	0.6	-0.6	-0.5
Arm fat mass (left)	0.4	1.8	2.2	1.5	1.4	1.5	-1.4	0.8	1.2
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	-0.6	-0.3	-1.0	0.7	-0.6	-0.6
Crohns Disease (2017)	0.3	0.6	1.2	-0.7	-1.0	-0.7	0.3	-1.1	-0.3
Age at First Birth	0.3	0.4	0.9	0.4	0.3	0.8	-0.6	0.9	0.5
HbA1C	0.3	0.3	0.5	-0.7	-0.6	-0.6	0.7	-0.1	-0.4
LDL Cholesterol	0.3	0.4	0.9	0.8	0.9	0.3	-0.6	0.7	0.0
Primary Biliary Cirrhosis	0.3	0.4	0.8	-0.7	-0.1	-0.1	0.9	-0.6	-0.9
Rheumatoid Arthritis	0.3	0.4	1.0	0.6	0.3	0.8	-0.5	1.0	0.6
Schizophrenia (2014)	0.3	0.8	2.0	1.1	1.4	0.5	-0.7	0.8	0.4
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.1	-0.3	0.3	-1.1	0.7	-0.7	-0.7
Age when periods started (menarche)	0.3	0.8	1.6	-1.3	-0.5	-0.9	0.9	-0.5	-1.0
High blood pressure (mother)	0.3	0.4	1.4	-0.6	-1.2	-0.7	0.4	-0.4	-0.3
Impedance of leg (left)	0.3	1.2	1.8	-1.2	-1.1	-0.8	1.3	-0.9	-1.3
Past tobacco smoking	0.3	0.5	1.0	0.6	1.0	0.9	-0.4	0.8	0.2
Nervous feelings	0.3	0.6	1.0	-0.4	-1.0	-0.9	0.9	-0.5	-0.9
Trunk fat-free mass	0.3	1.5	2.8	-1.0	-1.4	-0.9	1.0	-1.7	-1.1
Trunk predicted mass	0.3	1.7	3.1	-1.1	-1.5	-1.0	1.1	-1.8	-1.1
Length of working week for main job	0.3	0.3	0.5	0.6	0.5	0.7	-0.5	0.4	0.6
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.6	-0.6	0.4	-0.6	0.5	-0.8	-0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.9	-0.7	-0.9	-0.5	0.7	-0.6	-0.6
Medication: Amlodipine	0.3	0.5	1.2	0.7	1.1	0.4	-0.6	0.3	0.6
Arm fat-free mass (right)	0.3	1.6	2.8	-1.1	-1.2	-1.1	1.2	-1.7	-1.3
Exposure to tobacco smoke outside home	0.3	0.4	1.1	0.6	1.1	0.1	-0.6	0.4	0.6
Shortness of breath walking on level ground	0.3	0.4	1.0	0.6	0.3	1.0	-0.5	0.3	0.6
Whole body fat mass	0.3	1.2	1.6	1.2	1.2	1.3	-1.1	0.5	1.0
Leg fat mass (right)	0.3	1.3	1.8	1.3	1.2	1.3	-1.2	0.5	1.1
Arm predicted mass (right)	0.3	1.5	2.3	-1.1	-1.1	-1.1	1.2	-1.5	-1.2
Pulse rate, automated reading	0.3	1.0	1.6	-1.1	-0.6	-1.2	0.9	-1.3	-0.7
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	0.4	0.8	0.7	-0.5	0.3	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	0.6	-0.7	-0.6	-0.3	0.5	-0.7	-0.5
Friendships satisfaction	0.3	0.4	0.8	-0.5	-0.9	0.1	0.7	-0.5	-0.7
Medication: Gliclazide	0.3	0.4	0.6	-0.6	-0.1	-0.7	0.5	-0.8	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.3	-0.4	-1.1	-0.6	0.9	-0.9	-0.9
Average weekly champagne plus white wine intake	0.3	0.4	0.5	0.7	0.7	0.7	-0.6	0.7	0.6
Mother’s age at death	0.3	0.4	0.8	0.3	-0.6	0.6	-0.8	0.4	0.9
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.7	0.4	0.2	0.6	-0.6	0.3	0.8
Commuting to job workplace: Public transport	0.3	0.3	0.5	-0.6	-0.7	-0.7	0.5	-0.4	-0.5
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.8	-0.4	-0.1	-0.9	0.8	-0.7	-0.7
Medication: Atorvastatin	0.3	0.3	0.9	-0.9	-0.3	-0.6	0.7	-0.4	-0.5
Leg fat percentage (left)	0.3	0.9	1.2	1.1	1.1	1.1	-1.0	0.5	0.8
Arm fat-free mass (left)	0.3	1.3	2.3	-1.0	-1.3	-0.9	1.0	-1.5	-1.1
Ever depressed for a whole week	0.3	0.4	0.8	-0.7	-0.9	-0.4	0.6	-0.3	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.7	-0.2	0.0	-0.9	0.6	-0.7	-0.6
Reaction Time	0.2	0.4	1.0	0.5	0.7	0.1	-0.8	0.5	1.0
Breast Cancer	0.2	0.6	1.1	1.1	0.6	0.7	-0.9	0.1	0.9
Ovarian Cancer	0.2	0.3	1.5	-0.2	-1.2	0.1	0.1	0.0	-0.3
Mean Putamen Volume	0.2	0.2	0.4	0.5	0.5	-0.1	-0.6	0.2	0.7
Height	0.2	4.7	7.1	-1.9	-2.1	-1.7	2.6	-1.7	-2.7
Waist Hip Ratio (WHR)	0.2	1.1	1.3	-1.0	-1.2	-0.9	1.0	-1.1	-0.9
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.6	-0.5	-0.3	-0.1	0.7	-0.6	-0.8
Angina	0.2	0.2	0.5	-0.4	-0.0	-0.7	0.5	-0.5	-0.5
Diabetes (mother)	0.2	0.3	0.5	-0.5	-0.1	-0.4	0.7	-0.6	-0.7
Average weekly fortified wine intake	0.2	0.2	0.4	-0.5	-0.5	-0.0	0.5	-0.1	-0.6
Stomach or abdominal pain in last month	0.2	0.2	0.4	0.6	0.6	0.3	-0.3	0.4	0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.8	0.5	0.6	0.5	-0.3	0.9	0.2
Chronic bronchitis/emphysema (father)	0.2	0.3	0.6	-0.6	-0.4	-0.2	0.4	-0.8	-0.5
Trunk fat mass	0.2	0.9	1.5	1.1	1.1	1.2	-1.0	0.5	0.8
Mouth/teeth dental problems	0.2	0.3	0.7	0.5	-0.1	0.7	-0.2	0.8	0.2
Medication: Ramipril	0.2	0.2	0.4	-0.6	-0.2	-0.3	0.4	-0.6	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.2	-0.1	-0.1	-1.1	0.6	-0.3	-0.6
Falls in the last year	0.2	0.3	0.6	0.4	0.8	0.3	-0.6	-0.0	0.6
Birth weight of first child	0.2	0.3	0.5	-0.5	-0.2	-0.7	0.6	-0.5	-0.6
Medication: Paracetamol	0.2	0.4	1.0	-0.3	-1.0	-0.2	0.6	-0.7	-0.5
Glaucoma (self-reported)	0.2	0.3	1.1	-0.5	-1.1	-0.2	0.1	-0.4	-0.2
Number of full brothers	0.2	0.3	0.4	0.6	0.6	0.2	-0.7	0.2	0.6
Angina (self-reported)	0.2	0.3	0.6	-0.5	-0.2	-0.8	0.6	-0.5	-0.5
Medication: Omeprazole	0.2	0.2	0.7	-0.4	0.2	-0.9	0.3	-0.4	-0.1
Overall health rating	0.2	0.4	1.0	0.7	1.0	0.4	-0.5	0.3	0.5
Smoking status: Previous	0.2	0.2	0.5	-0.4	-0.7	-0.7	0.3	-0.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.5	-0.4	-1.2	0.1	0.6	-0.4	-0.7
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.4	0.6	0.6	0.4	-0.6	0.5	0.5
Osteoarthritis (self-reported)	0.2	0.2	0.6	-0.3	0.0	-0.8	0.5	-0.2	-0.5
Medication: Lisinopril	0.2	0.2	0.3	-0.4	-0.6	-0.6	0.4	-0.3	-0.4
Unable to work because of sickness or disability	0.2	0.3	0.8	0.6	0.9	0.2	-0.4	0.6	0.3
Commuting to job workplace: Cycle	0.2	0.2	0.4	0.4	0.5	0.1	-0.6	0.4	0.7
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	-0.1	0.6	-0.6	0.4	0.3	-0.5
Leg fat mass (left)	0.2	0.7	1.1	1.0	0.9	1.0	-0.9	0.3	0.8
Arm predicted mass (left)	0.2	1.1	2.0	-0.8	-1.1	-0.8	1.0	-1.4	-1.1
Bipolar Disorder or Schizophrenia	0.1	0.2	0.6	0.3	0.8	-0.4	-0.0	-0.2	-0.2
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	0.1	0.4	-0.2	-0.2	0.3	0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.5	0.3	-0.4	0.7	-0.2	0.2	0.2
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	-0.2	-0.6	-0.5	0.2	-0.4	0.0
Blood Red Count	0.1	0.5	1.4	0.8	0.8	1.2	-0.4	0.3	0.4
Blood White Count	0.1	0.5	1.9	-0.4	-1.0	-0.1	-0.0	-1.4	0.2
Heel T-Score	0.1	0.4	0.7	-0.6	0.5	-0.8	0.9	0.1	-0.8
BMI	0.1	0.5	0.9	0.8	1.0	0.6	-0.8	0.0	0.8
Systolic Blood Pressure	0.1	0.3	0.7	0.4	0.5	0.1	-0.6	0.8	0.7
Tanning	0.1	0.9	2.2	1.2	1.5	0.9	-0.7	0.6	0.5
Average weekly spirits intake	0.1	0.1	0.4	-0.2	-0.4	-0.0	0.5	0.3	-0.6
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.5	-0.1	-0.7	-0.3	0.1	0.0	0.0
Medication for hormone replacement therapy	0.1	0.1	0.3	-0.0	-0.1	-0.5	-0.1	-0.3	0.1
Supplements: Zinc	0.1	0.1	0.2	0.5	0.3	0.4	-0.4	0.4	0.4
Impedance of leg (right)	0.1	0.3	0.4	-0.4	-0.6	-0.2	0.7	-0.3	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.5	0.1	0.7	-0.3	-0.0	-0.2	0.1
High blood pressure	0.1	0.3	0.4	0.5	0.6	-0.0	-0.5	0.5	0.6
Multivitamins +/- minerals	0.1	0.1	0.2	0.4	0.2	0.4	-0.4	0.4	0.3
Alcohol usually taken with meals	0.1	0.2	0.7	0.2	-0.3	0.8	-0.5	0.2	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.9	-0.1	-0.0	-0.9	0.4	-0.1	-0.4
Had menopause	0.1	0.1	0.4	0.3	0.1	0.2	-0.4	0.7	0.4
Had other major operations	0.1	0.1	0.3	0.1	-0.2	-0.5	0.0	0.4	-0.1
Financial difficulties in last 2 years	0.1	0.1	0.3	-0.1	-0.5	0.2	0.3	-0.1	-0.3
Pain all over the body in last month	0.1	0.2	0.4	-0.1	0.7	-0.2	0.4	-0.2	-0.5
Illnesses of siblings	0.1	0.1	0.4	-0.2	-0.7	-0.2	0.2	-0.3	-0.3
Alcohol intake versus 10 years previously	0.1	0.1	0.3	0.1	-0.3	0.3	0.1	-0.5	-0.0
Pulse rate	0.1	0.1	0.3	-0.3	-0.2	-0.3	0.1	-0.5	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.4	-0.1	-0.6	-0.1	0.3	-0.3	-0.3
Medication: Cholesterol lowering	0.1	0.1	0.3	0.2	0.3	0.3	-0.1	0.5	0.0
Depression (self-reported)	0.1	0.1	0.2	-0.1	-0.4	0.5	0.1	-0.1	-0.3
Lung cancer (father)	0.1	0.1	0.3	0.2	0.5	0.0	-0.1	0.0	0.0
Impedance of arm (left)	0.1	0.3	0.8	0.3	0.4	0.9	-0.3	0.8	0.3
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	-0.5	-0.5	-0.7	0.7	0.2	-0.8
Blood clot in the leg (DVT)	0.1	0.2	0.5	0.1	0.4	-0.7	0.4	-0.4	-0.4
Headache pain in last month	0.1	0.1	0.2	0.2	-0.5	-0.3	0.1	-0.4	-0.2
Birth weight	0.1	0.3	0.5	0.5	0.4	0.7	-0.6	0.2	0.6
Comparative body size at age 10	0.1	0.2	0.4	0.6	0.4	0.0	-0.4	0.5	0.2
Age at first live birth	0.1	0.1	0.2	0.2	0.5	0.2	-0.4	0.0	0.4
Knee pain experienced in last month	0.1	0.1	0.6	-0.1	0.8	-0.3	0.1	0.1	-0.0
Illnesses of father: Heart disease	0.1	0.1	0.4	0.2	0.6	-0.4	-0.1	0.0	0.1
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.2	0.1	0.4	-0.2	0.3	0.2
Whole body fat-free mass	0.1	0.8	1.7	-0.7	-0.9	-0.6	0.7	-1.3	-0.8
Ever had bowel cancer screening	0.1	0.1	0.4	-0.0	-0.1	0.3	-0.4	0.6	0.3
Qualifications: nursing, teaching	0.1	0.1	0.4	-0.3	-0.6	0.1	0.0	-0.3	0.1
Commuting to job workplace: Walk	0.1	0.1	0.3	-0.3	-0.1	-0.3	0.5	0.2	-0.5
Medication for cholesterol	0.1	0.1	0.4	-0.4	-0.2	0.1	0.5	0.1	-0.6
Breast cancer (self-reported)	0.1	0.1	0.4	-0.1	-0.7	-0.1	-0.1	-0.3	-0.1
Whole body water mass	0.1	0.7	1.7	-0.7	-0.9	-0.5	0.7	-1.3	-0.8
Financial situation satisfaction	0.1	0.1	0.1	-0.3	-0.4	0.3	0.3	0.1	-0.1
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.2	-0.1	0.4	-0.4	0.3	0.4
Medication: Blood pressure	0.1	0.1	0.5	-0.3	-0.1	-0.7	0.3	-0.5	-0.1
Medication: Paracetamol	0.1	0.1	0.3	-0.0	-0.5	-0.2	0.3	-0.5	-0.3
Alcohol drinker status: Never	0.1	0.2	0.7	-0.4	-0.9	-0.1	0.2	-0.0	-0.3
Ever smoked	0.1	0.1	0.3	0.0	-0.3	-0.2	-0.4	-0.1	0.6
Basal metabolic rate	0.1	0.6	1.4	-0.5	-0.8	-0.4	0.6	-1.2	-0.7
Number of operations (self-reported)	0.1	0.1	0.4	-0.1	-0.6	-0.6	0.1	-0.2	-0.2
Diastolic blood pressure, automated reading	0.1	0.2	0.3	0.5	0.6	-0.1	-0.5	-0.4	0.6
Cholesterol lowering medication	0.1	0.2	0.5	0.3	0.4	0.1	-0.5	-0.0	0.7
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	-0.3	-0.1	-0.6	0.2	-0.3	0.0
Heart disease (siblings)	0.1	0.1	0.2	-0.1	0.3	-0.4	0.2	-0.4	-0.0
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	0.0	0.2	0.2	-0.1	0.1	0.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.1	0.1	0.2	0.1	0.1	-0.4	-0.3	0.3
Triglycerides	0.0	0.1	0.2	-0.4	-0.4	-0.1	0.3	-0.2	0.0
Blood Platelet Count	0.0	0.1	0.2	-0.2	-0.3	-0.1	0.3	-0.4	-0.2
Hair Pigment	0.0	0.2	0.5	0.1	-0.2	0.6	-0.0	0.7	0.0
Vitamin and mineral supplements	0.0	0.1	0.1	-0.1	-0.2	-0.2	0.3	-0.2	-0.3
Leg fat-free mass (left)	0.0	0.0	0.2	0.1	0.0	0.2	-0.0	-0.4	-0.1
Supplements: Glucosamine	0.0	0.0	0.1	0.0	0.3	-0.3	-0.0	-0.2	-0.0
Leg predicted mass (left)	0.0	0.0	0.2	0.1	-0.0	0.1	-0.0	-0.5	-0.1
Waist circumference	0.0	0.1	0.3	0.2	0.1	0.1	-0.1	-0.6	-0.0
Hearing difficulty/problems with background noise	0.0	0.0	0.2	0.2	-0.1	0.1	-0.1	0.5	0.1
Hair/balding pattern: Pattern 2	0.0	0.0	0.1	-0.2	0.3	-0.2	0.1	0.1	-0.1
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.1	-0.2	0.1	0.4	0.1	0.3	-0.0
Heart attack	0.0	0.0	0.1	-0.2	0.3	-0.1	0.0	0.0	0.3
Diabetes (self-reported)	0.0	0.1	0.2	0.2	0.5	0.3	-0.1	0.1	0.0
Weight	0.0	0.1	0.4	0.0	-0.1	0.1	0.1	-0.6	-0.2
Impedance of arm (right)	0.0	0.1	0.3	0.1	0.2	0.6	-0.3	0.5	0.2
Hip circumference	0.0	0.1	0.2	0.3	0.1	0.1	-0.1	-0.4	-0.0
Time employed in main current job	0.0	0.0	0.1	0.0	0.3	-0.3	0.1	-0.0	-0.0
Number of live births	0.0	0.0	0.1	-0.1	-0.3	0.0	0.1	0.3	0.0
Medication: Lansoprazole	0.0	0.0	0.2	0.1	0.1	0.1	-0.1	0.5	0.2
Breastfed as a baby	0.0	0.1	0.2	-0.0	-0.3	-0.1	-0.1	-0.5	0.1
Tense / ‘highly strung’	0.0	0.0	0.1	0.3	0.0	-0.1	-0.2	0.2	0.3
Peak expiratory flow (PEF)	0.0	0.1	0.3	-0.1	-0.6	-0.1	0.2	0.3	-0.2
Worry too long after embarrassment	0.0	0.0	0.1	0.3	0.2	0.1	0.0	0.3	-0.1
Health satisfaction	0.0	0.0	0.1	-0.1	-0.3	0.1	0.1	-0.4	0.1
Medication: Blood pressure	0.0	0.1	0.2	-0.2	-0.1	-0.4	0.2	-0.4	-0.3
Medication: Ibuprofen	0.0	0.0	0.2	0.1	-0.4	-0.0	0.1	-0.2	-0.1
Had major operations	0.0	0.0	0.1	0.3	0.2	0.1	-0.2	-0.1	0.2
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.1	-0.1	0.2	0.1	0.0	-0.3	-0.1
Leg fat-free mass (right)	0.0	0.2	0.6	-0.3	-0.3	-0.3	0.4	-0.8	-0.5
Diabetes diagnosed by doctor	0.0	0.0	0.0	-0.1	0.1	0.2	0.1	-0.1	-0.2
Leg predicted mass (right)	0.0	0.1	0.5	-0.2	-0.2	-0.1	0.3	-0.7	-0.4
Medication: Bendroflumethiazide	0.0	0.0	0.2	-0.0	0.4	-0.2	-0.1	-0.2	0.1
Age started oral contraceptive pill	0.0	0.0	0.1	0.1	0.1	0.3	-0.2	0.2	0.1
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	-0.1	-0.4	0.3	0.3	-0.1	-0.4
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	-0.3	0.1	-0.2	0.1	-0.1	0.2
Impedance of whole body	0.0	0.2	0.4	-0.5	-0.3	-0.1	0.6	-0.1	-0.6

Hub : Genes

ARHGEF16

Models

Trait associations