Hub : Genes

ARHGEF16

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.280	0.0560	6.6e-08	0.170	NA	0.178	NA	0.197	1.8e-11	NA	5.6e-12	NA	3.0e-13
2	GTEx	Nerve Tibial	0.207	0.0518	1.5e-05	0.089	NA	0.051	NA	0.084	6.9e-07	NA	1.5e-04	NA	1.6e-06
3	GTEx	Skin Sun Exposed Lower leg	0.220	0.0450	8.8e-09	0.077	NA	0.081	NA	0.090	6.4e-07	NA	3.0e-07	NA	6.6e-08
4	GTEx	Testis	0.261	0.0730	2.2e-04	0.206	NA	0.241	NA	0.244	1.6e-09	NA	4.5e-11	NA	3.6e-11
5	ROSMAP	Brain Pre-frontal Cortex	0.190	0.0316	5.2e-15	0.137	0.153	0.164	0.169	0.171	3.1e-17	3.9e-19	1.6e-20	3.8e-21	2.0e-21
6	TCGA	Brain Lower Grade Glioma	0.025	0.0153	6.4e-03	0.002	-0.001	-0.002	NA	0.020	1.8e-01	4.7e-01	5.5e-01	NA	2.2e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	2.0	3.2	3.9	-1.8	-1.6	-1.6	1.8	-2.0	-1.8
Bipolar Disorder or Schizophrenia	0.1	0.2	0.6	0.3	0.8	-0.4	-0.0	-0.2	-0.2
Depressed Affect (Nagel 2018)	1.0	2.2	2.8	-1.4	-1.0	-1.5	1.6	-1.7	-1.6
Depression (Nagel 2018)	0.7	1.1	2.5	-1.0	-0.1	-1.6	0.9	-1.2	-1.0
Intelligence (Savage-Jansen 2018)	1.3	4.1	6.4	2.0	1.4	2.5	-1.9	2.0	2.1
Neuroticism (Nagel 2018)	0.8	1.8	2.2	-1.2	-1.3	-1.4	1.4	-1.5	-1.3
Schizophrenia (2018)	1.2	2.4	5.1	1.8	2.2	0.8	-1.5	1.3	1.2
Schizophrenia vs Biploar Disorder	0.5	0.6	1.2	1.1	0.8	0.7	-0.9	0.8	0.0
Worry (Nagel 2018)	0.4	0.9	1.1	-0.8	-1.1	-1.0	0.9	-1.1	-0.8
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	0.1	0.4	-0.2	-0.2	0.3	0.3
Alzheimer’s Disease (in father)	0.4	0.4	0.8	0.5	0.9	0.8	-0.5	0.3	0.6
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	0.0	0.2	0.2	-0.1	0.1	0.3
Crohns Disease (2017)	0.3	0.6	1.2	-0.7	-1.0	-0.7	0.3	-1.1	-0.3
Irritable Bowel Disease (IBD)	1.2	3.0	4.2	-1.8	-2.1	-1.1	1.6	-1.9	-1.7
Ulcerative Colitis (UC)	1.6	3.1	4.2	-1.9	-2.0	-0.9	1.9	-1.6	-1.9
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.2	0.4	1.0	0.5	0.7	0.1	-0.8	0.5	1.0
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.5	0.3	-0.4	0.7	-0.2	0.2	0.2
Breast Cancer	0.2	0.6	1.1	1.1	0.6	0.7	-0.9	0.1	0.9
Ovarian Cancer	0.2	0.3	1.5	-0.2	-1.2	0.1	0.1	0.0	-0.3
Prostate Cancer	0.6	0.9	1.6	0.9	0.7	1.3	-0.7	1.2	0.5
Age at First Birth	0.3	0.4	0.9	0.4	0.3	0.8	-0.6	0.9	0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	-0.2	-0.6	-0.5	0.2	-0.4	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.1	0.1	0.2	0.1	0.1	-0.4	-0.3	0.3
Mean Putamen Volume	0.2	0.2	0.4	0.5	0.5	-0.1	-0.6	0.2	0.7
Fasting Glucose	1.2	1.4	2.2	-1.2	-1.0	-1.4	1.3	-0.5	-1.5
HbA1C	0.3	0.3	0.5	-0.7	-0.6	-0.6	0.7	-0.1	-0.4
HDL Cholesterol	0.6	1.0	1.4	-1.0	-1.1	-1.1	0.9	-1.2	0.0
LDL Cholesterol	0.3	0.4	0.9	0.8	0.9	0.3	-0.6	0.7	0.0
Lupus	0.6	0.9	1.6	0.7	1.0	0.5	-1.2	0.7	1.3
Neuroticism (2016)	1.7	2.5	3.5	-1.5	-1.3	-1.5	1.6	-1.6	-1.9
Primary Biliary Cirrhosis	0.3	0.4	0.8	-0.7	-0.1	-0.1	0.9	-0.6	-0.9
Rheumatoid Arthritis	0.3	0.4	1.0	0.6	0.3	0.8	-0.5	1.0	0.6
Schizophrenia (2014)	0.3	0.8	2.0	1.1	1.4	0.5	-0.7	0.8	0.4
Triglycerides	0.0	0.1	0.2	-0.4	-0.4	-0.1	0.3	-0.2	0.0
Type 2 Diabetes (T2D) (2012)	1.0	1.1	1.9	-1.3	-0.3	-1.4	1.2	-1.4	0.0
Ulcerative Colitis	3.3	4.9	6.0	-2.4	-2.3	-1.6	2.5	-1.8	-2.4
Blood Eosinophil Count	0.7	5.7	12.0	-2.4	-2.6	-1.5	2.0	-3.5	-1.8
Blood Platelet Count	0.0	0.1	0.2	-0.2	-0.3	-0.1	0.3	-0.4	-0.2
Blood Red Count	0.1	0.5	1.4	0.8	0.8	1.2	-0.4	0.3	0.4
Blood White Count	0.1	0.5	1.9	-0.4	-1.0	-0.1	-0.0	-1.4	0.2
Heel T-Score	0.1	0.4	0.7	-0.6	0.5	-0.8	0.9	0.1	-0.8
BMI	0.1	0.5	0.9	0.8	1.0	0.6	-0.8	0.0	0.8
Height	0.2	4.7	7.1	-1.9	-2.1	-1.7	2.6	-1.7	-2.7
Waist Hip Ratio (WHR)	0.2	1.1	1.3	-1.0	-1.2	-0.9	1.0	-1.1	-0.9
Systolic Blood Pressure	0.1	0.3	0.7	0.4	0.5	0.1	-0.6	0.8	0.7
Smoking Status	0.6	1.4	3.4	-1.3	-1.8	-0.7	0.9	-1.3	-0.8
Allergy or Eczema	0.5	1.3	2.5	-1.0	-1.6	-0.9	1.0	-1.4	-0.9
Cardiovascular Disease	1.3	4.2	4.8	2.0	1.9	2.0	-2.1	2.1	2.2
Hypothyroidism (self reported)	0.4	0.9	1.3	-0.8	-1.1	-0.8	0.9	-1.1	-0.8
Respiratory disease	1.7	3.9	7.1	-1.8	-1.4	-2.3	1.8	-2.7	-1.5
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.6	-0.5	-0.3	-0.1	0.7	-0.6	-0.8
Lung FEV1/FVC ratio	5.9	30.1	46.1	5.5	4.0	6.8	-5.1	6.1	5.0
Lung FVC	2.0	10.1	11.8	-2.9	-3.0	-3.4	3.1	-3.4	-3.2
Neuroticism	2.6	6.2	7.4	-2.3	-2.7	-2.4	2.6	-2.4	-2.5
Chronotype (morning person)	4.8	11.2	14.0	3.7	3.2	3.7	-3.3	2.9	3.2
Hair Pigment	0.0	0.2	0.5	0.1	-0.2	0.6	-0.0	0.7	0.0
Tanning	0.1	0.9	2.2	1.2	1.5	0.9	-0.7	0.6	0.5
Hand grip strength (left)	0.8	2.0	2.6	1.5	1.6	1.6	-1.1	1.6	1.1
Number of treatments/medications taken	1.3	2.3	3.8	-1.4	-1.1	-2.0	1.6	-1.6	-1.5
Average weekly spirits intake	0.1	0.1	0.4	-0.2	-0.4	-0.0	0.5	0.3	-0.6
Sensitivity / hurt feelings	0.5	0.8	1.5	-0.7	-0.9	-1.1	0.6	-1.2	-0.6
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.1	-0.3	0.3	-1.1	0.7	-0.7	-0.7
Hearing difficulty/problems: Yes	0.9	1.4	1.9	1.1	1.2	0.9	-1.2	1.1	1.4
Relative age of first facial hair	1.1	2.2	3.3	1.5	1.2	1.8	-1.3	1.8	1.2
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	5.2	-1.1	-0.4	-2.3	1.2	-1.7	-1.0
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.5	-0.1	-0.7	-0.3	0.1	0.0	0.0
Ever had hysterectomy (womb removed)	0.7	0.8	1.3	-0.8	-0.6	-1.1	0.8	-1.1	-0.8
Systolic blood pressure, automated reading	0.5	1.6	2.2	1.4	1.2	0.8	-1.4	1.1	1.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.5	0.1	-0.3	1.2	-0.1	0.9	0.2
Angina	0.2	0.2	0.5	-0.4	-0.0	-0.7	0.5	-0.5	-0.5
Medication for hormone replacement therapy	0.1	0.1	0.3	-0.0	-0.1	-0.5	-0.1	-0.3	0.1
Vitamin and mineral supplements	0.0	0.1	0.1	-0.1	-0.2	-0.2	0.3	-0.2	-0.3
Supplements: Zinc	0.1	0.1	0.2	0.5	0.3	0.4	-0.4	0.4	0.4
Medication: Co-codamol	0.8	0.9	1.5	-1.1	-0.7	-1.2	0.9	-0.8	-0.9
Medication: Metformin	0.8	1.1	2.0	-1.2	-0.8	-0.7	1.1	-1.4	-1.1
Diabetes (father)	0.4	0.5	1.3	0.6	1.2	0.4	-0.4	0.7	0.4
Diabetes (mother)	0.2	0.3	0.5	-0.5	-0.1	-0.4	0.7	-0.6	-0.7
Severe depression (siblings)	1.0	1.1	2.1	-1.0	-1.4	-1.0	0.5	-1.5	-0.6
Pack years adult smoking proportion	0.4	0.7	1.0	0.9	0.8	0.6	-0.7	1.0	0.7
Impedance of leg (right)	0.1	0.3	0.4	-0.4	-0.6	-0.2	0.7	-0.3	-0.6
Leg fat-free mass (left)	0.0	0.0	0.2	0.1	0.0	0.2	-0.0	-0.4	-0.1
Trunk fat percentage	0.5	2.1	2.8	1.6	1.7	1.7	-1.4	1.1	1.2
Hand grip strength (right)	0.4	1.2	2.6	1.2	0.9	1.6	-0.7	1.1	0.7
Townsend deprivation index at recruitment	1.3	1.9	2.6	-1.1	-1.0	-1.4	1.6	-1.3	-1.6
Current tobacco smoking	0.8	1.3	2.5	-1.2	-1.6	-0.4	1.2	-1.1	-1.2
Average weekly fortified wine intake	0.2	0.2	0.4	-0.5	-0.5	-0.0	0.5	-0.1	-0.6
Maternal smoking around birth	0.4	0.6	1.8	0.6	1.3	0.7	-0.6	0.7	0.6
Fed-up feelings	1.9	3.4	4.2	-1.7	-1.4	-2.0	2.0	-1.8	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.5	0.1	0.7	-0.3	-0.0	-0.2	0.1
Relative age voice broke	0.9	1.5	2.6	1.2	0.9	1.6	-1.0	1.4	0.9
Taking other prescription medications	1.1	1.6	1.9	-1.3	-1.0	-1.4	1.4	-1.3	-1.3
Age when periods started (menarche)	0.3	0.8	1.6	-1.3	-0.5	-0.9	0.9	-0.5	-1.0
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	1.8	-1.1	-0.8	-1.0	1.1	-0.9	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.6	2.9	-1.7	-1.4	-1.4	1.7	-1.7	-1.7
Tinnitus: Yes, but not now, but have in the past	14.8	15.8	16.5	-3.9	-3.9	-4.1	4.0	-3.9	-4.0
Qualifications: CSEs or equivalent	0.8	1.1	2.2	-1.1	-0.5	-1.5	0.9	-1.0	-1.0
Serious illness, injury or assault to yourself	0.4	0.5	0.7	0.8	0.7	0.2	-0.7	0.8	0.7
High blood pressure	0.1	0.3	0.4	0.5	0.6	-0.0	-0.5	0.5	0.6
Hayfever, allergic rhinitis or eczema	1.1	2.3	3.6	-1.4	-1.6	-1.4	1.4	-1.9	-1.4
Multivitamins +/- minerals	0.1	0.1	0.2	0.4	0.2	0.4	-0.4	0.4	0.3
Stomach or abdominal pain in last month	0.2	0.2	0.4	0.6	0.6	0.3	-0.3	0.4	0.4
Supplements: Glucosamine	0.0	0.0	0.1	0.0	0.3	-0.3	-0.0	-0.2	-0.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.8	0.5	0.6	0.5	-0.3	0.9	0.2
Medication: Atenolol	0.8	1.0	1.2	-0.8	-0.9	-1.0	1.1	-1.0	-1.1
Medication: Levothyroxine sodium	2.0	3.4	4.5	-1.8	-1.6	-1.8	2.1	-1.7	-2.0
Sitting height	1.5	10.9	15.0	-3.1	-3.9	-2.7	3.4	-3.2	-3.4
Chronic bronchitis/emphysema (father)	0.2	0.3	0.6	-0.6	-0.4	-0.2	0.4	-0.8	-0.5
High blood pressure (mother)	0.3	0.4	1.4	-0.6	-1.2	-0.7	0.4	-0.4	-0.3
Body mass index (BMI)	0.4	1.5	2.1	1.4	1.4	1.1	-1.4	0.8	1.2
Impedance of leg (left)	0.3	1.2	1.8	-1.2	-1.1	-0.8	1.3	-0.9	-1.3
Leg predicted mass (left)	0.0	0.0	0.2	0.1	-0.0	0.1	-0.0	-0.5	-0.1
Trunk fat mass	0.2	0.9	1.5	1.1	1.1	1.2	-1.0	0.5	0.8
Waist circumference	0.0	0.1	0.3	0.2	0.1	0.1	-0.1	-0.6	-0.0
Number of incorrect matches in round	0.7	1.2	1.9	-1.1	-1.4	-0.4	1.2	-0.9	-1.2
Past tobacco smoking	0.3	0.5	1.0	0.6	1.0	0.9	-0.4	0.8	0.2
Alcohol usually taken with meals	0.1	0.2	0.7	0.2	-0.3	0.8	-0.5	0.2	0.5
Nervous feelings	0.3	0.6	1.0	-0.4	-1.0	-0.9	0.9	-0.5	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.9	-0.1	-0.0	-0.9	0.4	-0.1	-0.4
Hearing difficulty/problems with background noise	0.0	0.0	0.2	0.2	-0.1	0.1	-0.1	0.5	0.1
Hair/balding pattern: Pattern 2	0.0	0.0	0.1	-0.2	0.3	-0.2	0.1	0.1	-0.1
Had menopause	0.1	0.1	0.4	0.3	0.1	0.2	-0.4	0.7	0.4
Had other major operations	0.1	0.1	0.3	0.1	-0.2	-0.5	0.0	0.4	-0.1
Forced vital capacity (FVC)	3.6	14.0	16.1	-3.5	-3.7	-3.7	3.9	-3.6	-4.0
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	3.3	-1.8	-1.7	-1.5	1.6	-1.4	-1.7
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.1	-0.2	0.1	0.4	0.1	0.3	-0.0
Qualifications: None of the above	0.7	1.6	2.9	1.4	1.7	1.1	-0.9	1.4	0.8
Financial difficulties in last 2 years	0.1	0.1	0.3	-0.1	-0.5	0.2	0.3	-0.1	-0.3
Mouth/teeth dental problems	0.2	0.3	0.7	0.5	-0.1	0.7	-0.2	0.8	0.2
Heart attack	0.0	0.0	0.1	-0.2	0.3	-0.1	0.0	0.0	0.3
Allergy	1.5	3.5	6.7	1.5	1.4	2.2	-1.7	2.6	1.6
Pain all over the body in last month	0.1	0.2	0.4	-0.1	0.7	-0.2	0.4	-0.2	-0.5
Diabetes (self-reported)	0.0	0.1	0.2	0.2	0.5	0.3	-0.1	0.1	0.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.2	-0.9	-0.5	-1.0	1.0	-1.1	-1.0
Medication: Ramipril	0.2	0.2	0.4	-0.6	-0.2	-0.3	0.4	-0.6	-0.4
Medication: Simvastatin	0.9	1.3	1.6	1.1	1.1	1.3	-1.2	0.9	1.1
Fluid intelligence score	0.4	0.8	1.2	1.0	0.2	1.1	-0.9	0.8	0.9
Illnesses of siblings	0.1	0.1	0.4	-0.2	-0.7	-0.2	0.2	-0.3	-0.3
Neuroticism score	1.7	3.6	4.3	-1.7	-1.7	-1.9	2.1	-2.0	-2.0
Weight	0.0	0.1	0.4	0.0	-0.1	0.1	0.1	-0.6	-0.2
Impedance of arm (right)	0.0	0.1	0.3	0.1	0.2	0.6	-0.3	0.5	0.2
Arm fat percentage (right)	1.0	3.8	4.4	2.1	2.1	2.0	-2.1	1.5	1.9
Trunk fat-free mass	0.3	1.5	2.8	-1.0	-1.4	-0.9	1.0	-1.7	-1.1
Hip circumference	0.0	0.1	0.2	0.3	0.1	0.1	-0.1	-0.4	-0.0
Time employed in main current job	0.0	0.0	0.1	0.0	0.3	-0.3	0.1	-0.0	-0.0
Alcohol intake versus 10 years previously	0.1	0.1	0.3	0.1	-0.3	0.3	0.1	-0.5	-0.0
Father’s age at death	0.4	0.6	1.3	0.8	0.2	1.1	-0.8	0.7	0.7
Worrier / anxious feelings	0.9	1.7	1.9	-1.1	-1.3	-1.4	1.4	-1.1	-1.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.2	-0.1	-0.1	-1.1	0.6	-0.3	-0.6
Falls in the last year	0.2	0.3	0.6	0.4	0.8	0.3	-0.6	-0.0	0.6
Hair/balding pattern: Pattern 3	0.5	0.8	1.6	0.7	0.6	1.2	-1.0	0.4	1.2
Number of live births	0.0	0.0	0.1	-0.1	-0.3	0.0	0.1	0.3	0.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	2.9	-1.0	-1.5	-0.8	1.5	-0.9	-1.7
Pulse rate	0.1	0.1	0.3	-0.3	-0.2	-0.3	0.1	-0.5	0.0
Happiness	0.4	0.4	0.9	0.6	0.1	0.9	-0.5	0.8	0.6
Noisy workplace	0.4	0.5	1.5	0.6	1.2	0.3	-0.5	0.5	0.7
Qualifications: A levels/AS levels or equivalent	0.6	1.4	3.2	-1.4	-0.8	-1.2	0.8	-1.8	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	1.9	-1.2	-1.4	-1.2	1.0	-1.2	-0.9
Mouth/teeth dental problems: Dentures	2.0	3.4	4.4	1.8	2.1	1.5	-1.9	1.9	1.8
Asthma	2.7	5.3	9.5	-2.1	-2.0	-2.4	2.1	-3.1	-1.9
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.4	-0.1	-0.6	-0.1	0.3	-0.3	-0.3
Medication: Cholesterol lowering	0.1	0.1	0.3	0.2	0.3	0.3	-0.1	0.5	0.0
Depression (self-reported)	0.1	0.1	0.2	-0.1	-0.4	0.5	0.1	-0.1	-0.3
Medication: Lansoprazole	0.0	0.0	0.2	0.1	0.1	0.1	-0.1	0.5	0.2
Prospective memory result	2.8	3.4	4.8	-1.7	-1.7	-1.9	1.7	-2.2	-1.8
Lung cancer (father)	0.1	0.1	0.3	0.2	0.5	0.0	-0.1	0.0	0.0
Illnesses of mother	0.8	0.9	1.4	1.1	1.0	1.0	-0.8	1.2	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	2.3	-0.8	-1.5	-1.0	1.3	-0.8	-1.5
Pulse wave Arterial Stiffness index	2.5	2.9	3.9	-1.6	-2.0	-1.5	1.8	-1.6	-1.7
Impedance of arm (left)	0.1	0.3	0.8	0.3	0.4	0.9	-0.3	0.8	0.3
Arm fat mass (right)	0.4	1.6	2.1	1.4	1.3	1.4	-1.4	0.7	1.1
Trunk predicted mass	0.3	1.7	3.1	-1.1	-1.5	-1.0	1.1	-1.8	-1.1
Standing height	0.7	6.6	7.7	-2.5	-2.8	-1.8	2.8	-2.6	-2.8
Length of working week for main job	0.3	0.3	0.5	0.6	0.5	0.7	-0.5	0.4	0.6
Exposure to tobacco smoke at home	0.8	0.9	1.3	-1.1	-0.9	-0.7	1.1	-0.8	-0.8
Breastfed as a baby	0.0	0.1	0.2	-0.0	-0.3	-0.1	-0.1	-0.5	0.1
Tense / ‘highly strung’	0.0	0.0	0.1	0.3	0.0	-0.1	-0.2	0.2	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	1.4	-1.1	-0.8	-1.2	0.9	-1.1	-0.8
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	-0.5	-0.5	-0.7	0.7	0.2	-0.8
Birth weight of first child	0.2	0.3	0.5	-0.5	-0.2	-0.7	0.6	-0.5	-0.6
Peak expiratory flow (PEF)	0.0	0.1	0.3	-0.1	-0.6	-0.1	0.2	0.3	-0.2
Pulse wave reflection index	2.5	3.1	4.5	-1.7	-1.9	-1.2	2.0	-1.4	-2.1
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.6	-0.6	0.4	-0.6	0.5	-0.8	-0.6
Loud music exposure frequency	1.2	1.3	1.8	-1.2	-1.1	-1.3	1.2	-0.9	-1.1
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	4.3	-1.9	-1.4	-1.6	1.5	-2.1	-1.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.7	-0.8	-0.4	-1.1	0.7	-1.3	-0.7
Blood clot in the leg (DVT)	0.1	0.2	0.5	0.1	0.4	-0.7	0.4	-0.4	-0.4
Medication: Paracetamol	0.2	0.4	1.0	-0.3	-1.0	-0.2	0.6	-0.7	-0.5
Headache pain in last month	0.1	0.1	0.2	0.2	-0.5	-0.3	0.1	-0.4	-0.2
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.9	-0.7	-0.9	-0.5	0.7	-0.6	-0.6
Glaucoma (self-reported)	0.2	0.3	1.1	-0.5	-1.1	-0.2	0.1	-0.4	-0.2
Gout (self-reported)	1.4	1.9	3.7	1.3	1.9	0.6	-1.3	1.5	1.3
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	2.1	-1.3	-1.5	-1.0	1.4	-1.4	-1.4
Medication: Amlodipine	0.3	0.5	1.2	0.7	1.1	0.4	-0.6	0.3	0.6
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.6	-0.7	-0.6	-1.3	0.7	-1.3	-0.6
Birth weight	0.1	0.3	0.5	0.5	0.4	0.7	-0.6	0.2	0.6
Chronic bronchitis/emphysema (mother)	1.3	1.5	2.1	-1.3	-1.3	-1.2	1.1	-1.4	-1.0
High blood pressure (siblings)	1.3	1.9	3.1	1.3	1.8	1.0	-1.3	1.4	1.4
Forced vital capacity (FVC), Best measure	2.7	10.0	11.5	-2.9	-3.2	-3.1	3.2	-3.1	-3.4
Body fat percentage	0.6	2.4	3.0	1.7	1.7	1.7	-1.5	1.1	1.3
Leg fat percentage (right)	0.5	1.9	2.6	1.6	1.4	1.5	-1.5	0.8	1.3
Arm fat-free mass (right)	0.3	1.6	2.8	-1.1	-1.2	-1.1	1.2	-1.7	-1.3
Exposure to tobacco smoke outside home	0.3	0.4	1.1	0.6	1.1	0.1	-0.6	0.4	0.6
Comparative body size at age 10	0.1	0.2	0.4	0.6	0.4	0.0	-0.4	0.5	0.2
Number of full brothers	0.2	0.3	0.4	0.6	0.6	0.2	-0.7	0.2	0.6
Worry too long after embarrassment	0.0	0.0	0.1	0.3	0.2	0.1	0.0	0.3	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	2.2	-1.3	-1.3	-1.0	1.3	-1.5	-1.1
Wheeze or whistling in the chest in last year	0.9	1.7	3.1	-1.3	-0.9	-1.4	1.1	-1.8	-1.0
Number of children fathered	1.0	1.1	1.9	1.2	1.4	0.9	-1.0	1.1	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.0	1.1	0.0	1.4	-1.1	0.8	1.1
Age at first live birth	0.1	0.1	0.2	0.2	0.5	0.2	-0.4	0.0	0.4
Pulse wave peak to peak time	2.6	3.1	4.0	1.7	2.0	1.6	-1.9	1.6	1.8
Health satisfaction	0.0	0.0	0.1	-0.1	-0.3	0.1	0.1	-0.4	0.1
Shortness of breath walking on level ground	0.3	0.4	1.0	0.6	0.3	1.0	-0.5	0.3	0.6
Qualifications: College or University degree	0.4	1.3	1.7	1.2	1.1	1.0	-1.3	1.1	1.2
Eye problems/disorders: None of the above	2.8	3.2	5.2	-1.8	-1.3	-2.3	1.7	-2.0	-1.6
Mouth/teeth dental problems: Loose teeth	0.6	0.8	1.2	0.9	0.4	0.9	-1.0	0.6	1.1
Emphysema/chronic bronchitis	0.7	0.8	2.3	-0.8	-0.1	-0.9	0.8	-1.5	-0.6
Medication for pain relief, constipation, heartburn	0.4	0.7	1.1	0.7	0.9	0.8	-1.1	0.6	0.9
Neck or shoulder pain in last month	2.2	3.2	4.4	-1.8	-1.7	-2.1	1.6	-1.9	-1.5
Medication: Blood pressure	0.0	0.1	0.2	-0.2	-0.1	-0.4	0.2	-0.4	-0.3
Angina (self-reported)	0.2	0.3	0.6	-0.5	-0.2	-0.8	0.6	-0.5	-0.5
Migraine (self-reported)	4.5	5.5	6.9	2.5	1.7	2.4	-2.6	2.3	2.6
Medication: Ibuprofen	0.0	0.0	0.2	0.1	-0.4	-0.0	0.1	-0.2	-0.1
Medication: Allopurinol	1.1	1.4	3.2	1.2	1.8	0.4	-1.0	1.2	1.0
Medication: Omeprazole	0.2	0.2	0.7	-0.4	0.2	-0.9	0.3	-0.4	-0.1
Medication: Seretide 50 evohaler	0.8	0.9	1.6	-0.9	-0.2	-1.3	0.9	-1.2	-0.8
Mean time to correctly identify matches	0.4	0.8	1.3	0.8	0.8	0.5	-1.0	0.8	1.1
Heart disease (mother)	0.5	0.7	1.2	-0.8	-0.5	-1.1	0.8	-0.8	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.0	-0.7	-1.0	-0.7	0.4	-1.0	-0.2
Whole body fat mass	0.3	1.2	1.6	1.2	1.2	1.3	-1.1	0.5	1.0
Leg fat mass (right)	0.3	1.3	1.8	1.3	1.2	1.3	-1.2	0.5	1.1
Arm predicted mass (right)	0.3	1.5	2.3	-1.1	-1.1	-1.1	1.2	-1.5	-1.2
Pulse rate, automated reading	0.3	1.0	1.6	-1.1	-0.6	-1.2	0.9	-1.3	-0.7
Alcohol intake frequency.	1.0	2.3	3.2	-1.3	-1.6	-1.4	1.4	-1.8	-1.5
Comparative height size at age 10	0.6	3.1	4.5	-1.6	-1.2	-1.7	2.0	-1.7	-2.1
Number of full sisters	0.5	0.6	1.2	-0.7	-0.0	-1.1	0.8	-1.0	-0.7
Suffer from ‘nerves’	0.8	1.3	2.0	-1.0	-1.4	-1.1	1.0	-1.1	-1.0
Overall health rating	0.2	0.4	1.0	0.7	1.0	0.4	-0.5	0.3	0.5
Chest pain or discomfort	0.9	1.3	3.3	-0.8	-0.1	-1.8	0.9	-1.5	-0.8
Had major operations	0.0	0.0	0.1	0.3	0.2	0.1	-0.2	-0.1	0.2
Age at last live birth	0.5	0.7	1.1	-0.9	-0.7	-1.0	0.7	-0.9	-0.6
Family relationship satisfaction	1.5	1.9	2.6	-1.5	-1.4	-0.8	1.6	-1.4	-1.5
Leg pain on walking	2.0	2.5	3.6	-1.4	-1.5	-1.9	1.7	-1.5	-1.4
Qualifications: NVQ or HND or HNC or equivalent	2.6	3.1	4.7	-1.6	-1.7	-2.2	1.7	-1.6	-1.7
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	0.4	0.8	0.7	-0.5	0.3	0.6
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.1	-0.1	0.2	0.1	0.0	-0.3	-0.1
Medication: Aspirin	1.4	1.8	2.7	-1.4	-0.8	-1.6	1.6	-0.9	-1.5
Supplements: Vitamin C	0.8	1.0	1.1	-1.1	-1.0	-0.9	1.1	-0.8	-1.0
Knee pain experienced in last month	0.1	0.1	0.6	-0.1	0.8	-0.3	0.1	0.1	-0.0
Hypertension (Self-reported)	0.4	1.1	1.5	1.0	1.1	0.7	-1.1	1.0	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.9	3.4	4.9	-1.9	-1.8	-1.6	2.2	-1.3	-2.2
Illnesses of father: Heart disease	0.1	0.1	0.4	0.2	0.6	-0.4	-0.1	0.0	0.1
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.2	0.1	0.4	-0.2	0.3	0.2
Smoking status: Previous	0.2	0.2	0.5	-0.4	-0.7	-0.7	0.3	-0.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.5	-0.4	-1.2	0.1	0.6	-0.4	-0.7
Whole body fat-free mass	0.1	0.8	1.7	-0.7	-0.9	-0.6	0.7	-1.3	-0.8
Leg fat-free mass (right)	0.0	0.2	0.6	-0.3	-0.3	-0.3	0.4	-0.8	-0.5
Arm fat percentage (left)	1.1	4.3	4.9	2.2	2.2	2.2	-2.2	1.6	2.0
Average weekly red wine intake	1.0	1.5	2.5	-1.2	-1.0	-1.6	1.2	-1.1	-1.3
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.4	0.6	0.6	0.4	-0.6	0.5	0.5
Mood swings	1.1	1.9	3.2	-1.1	-1.0	-1.8	1.5	-1.2	-1.5
Loneliness, isolation	0.5	0.6	0.9	-0.8	-0.5	-0.5	0.9	-1.0	-0.9
Long-standing illness, disability or infirmity	2.6	3.9	6.1	-1.9	-1.6	-2.1	1.9	-2.5	-1.8
Ever had bowel cancer screening	0.1	0.1	0.4	-0.0	-0.1	0.3	-0.4	0.6	0.3
Diabetes diagnosed by doctor	0.0	0.0	0.0	-0.1	0.1	0.2	0.1	-0.1	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	0.6	-0.7	-0.6	-0.3	0.5	-0.7	-0.5
Friendships satisfaction	0.3	0.4	0.8	-0.5	-0.9	0.1	0.7	-0.5	-0.7
Qualifications: nursing, teaching	0.1	0.1	0.4	-0.3	-0.6	0.1	0.0	-0.3	0.1
Commuting to job workplace: Walk	0.1	0.1	0.3	-0.3	-0.1	-0.3	0.5	0.2	-0.5
Eye problems/disorders: Cataract	1.9	2.2	3.1	1.6	1.4	1.8	-1.5	1.1	1.4
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	1.9	-1.2	-0.6	-1.4	1.1	-1.3	-0.9
Medication for cholesterol	0.1	0.1	0.4	-0.4	-0.2	0.1	0.5	0.1	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	2.5	-1.6	-0.9	-1.0	1.2	-1.4	-1.1
Back pain experienced in last month	0.4	0.6	1.5	-0.8	-0.2	-1.2	0.7	-0.4	-0.7
Mineral and other dietary supplements	0.4	0.5	0.9	-0.6	-0.2	-0.9	0.9	-0.5	-0.8
Breast cancer (self-reported)	0.1	0.1	0.4	-0.1	-0.7	-0.1	-0.1	-0.3	-0.1
Asthma (self-reported)	2.3	4.7	8.6	-1.9	-1.9	-2.4	1.9	-2.9	-1.7
Osteoporosis (self-reported)	1.7	2.2	3.0	-1.6	-1.2	-1.6	1.3	-1.7	-1.3
Osteoarthritis (self-reported)	0.2	0.2	0.6	-0.3	0.0	-0.8	0.5	-0.2	-0.5
Medication: Aspirin	0.5	0.7	1.2	-0.9	-0.5	-1.1	0.9	-0.6	-0.8
Medication: Gliclazide	0.3	0.4	0.6	-0.6	-0.1	-0.7	0.5	-0.8	-0.6
Illnesses of father: None of the above (group 1)	0.4	0.5	1.4	-0.6	-1.2	-0.1	0.6	-0.6	-0.5
Smoking status: Current	1.1	1.7	2.9	-1.4	-1.7	-0.6	1.3	-1.2	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.3	-0.4	-1.1	-0.6	0.9	-0.9	-0.9
Whole body water mass	0.1	0.7	1.7	-0.7	-0.9	-0.5	0.7	-1.3	-0.8
Leg predicted mass (right)	0.0	0.1	0.5	-0.2	-0.2	-0.1	0.3	-0.7	-0.4
Arm fat mass (left)	0.4	1.8	2.2	1.5	1.4	1.5	-1.4	0.8	1.2
Number of self-reported non-cancer illnesses	0.5	0.9	2.0	-0.7	-0.7	-1.2	0.7	-1.4	-0.7
Average weekly champagne plus white wine intake	0.3	0.4	0.5	0.7	0.7	0.7	-0.6	0.7	0.6
Miserableness	0.6	1.0	1.5	-0.8	-0.7	-1.2	1.2	-0.8	-1.2
Guilty feelings	4.5	6.7	8.0	-2.5	-2.2	-2.7	2.8	-2.5	-2.8
Wears glasses or contact lenses	5.3	6.1	7.0	2.5	2.2	2.5	-2.6	2.5	2.6
Ever taken oral contraceptive pill	3.6	4.0	5.1	-2.1	-1.6	-2.1	2.2	-1.6	-2.2
Hearing aid user	0.6	0.6	0.8	-0.9	-0.7	-0.9	0.9	-0.5	-0.9
Mother’s age at death	0.3	0.4	0.8	0.3	-0.6	0.6	-0.8	0.4	0.9
Financial situation satisfaction	0.1	0.1	0.1	-0.3	-0.4	0.3	0.3	0.1	-0.1
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.7	0.4	0.2	0.6	-0.6	0.3	0.8
Commuting to job workplace: Public transport	0.3	0.3	0.5	-0.6	-0.7	-0.7	0.5	-0.4	-0.5
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.2	-0.1	0.4	-0.4	0.3	0.4
Medication: Blood pressure	0.1	0.1	0.5	-0.3	-0.1	-0.7	0.3	-0.5	-0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.8	-0.4	-0.1	-0.9	0.8	-0.7	-0.7
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.6	0.9	0.3	1.3	-1.1	0.8	1.1
High cholesterol (Self-reported)	1.3	2.2	2.6	1.5	1.3	1.5	-1.6	1.5	1.6
Medication: Bendroflumethiazide	0.0	0.0	0.2	-0.0	0.4	-0.2	-0.1	-0.2	0.1
Medication: Paracetamol	0.1	0.1	0.3	-0.0	-0.5	-0.2	0.3	-0.5	-0.3
Medication: Lisinopril	0.2	0.2	0.3	-0.4	-0.6	-0.6	0.4	-0.3	-0.4
Medication: Atorvastatin	0.3	0.3	0.9	-0.9	-0.3	-0.6	0.7	-0.4	-0.5
Illnesses of father: High blood pressure	0.8	1.0	2.2	1.0	1.5	0.2	-0.9	0.7	1.1
Alcohol drinker status: Never	0.1	0.2	0.7	-0.4	-0.9	-0.1	0.2	-0.0	-0.3
Ever smoked	0.1	0.1	0.3	0.0	-0.3	-0.2	-0.4	-0.1	0.6
Basal metabolic rate	0.1	0.6	1.4	-0.5	-0.8	-0.4	0.6	-1.2	-0.7
Leg fat percentage (left)	0.3	0.9	1.2	1.1	1.1	1.1	-1.0	0.5	0.8
Arm fat-free mass (left)	0.3	1.3	2.3	-1.0	-1.3	-0.9	1.0	-1.5	-1.1
Number of operations (self-reported)	0.1	0.1	0.4	-0.1	-0.6	-0.6	0.1	-0.2	-0.2
Average weekly beer plus cider intake	1.1	1.7	2.5	-1.2	-0.3	-1.6	1.4	-1.4	-1.4
Irritability	0.6	1.0	3.0	-0.8	-0.8	-1.7	1.0	-0.5	-0.9
Risk taking	1.9	2.8	5.0	-1.5	-1.1	-2.2	1.6	-1.9	-1.5
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	-0.6	-0.3	-1.0	0.7	-0.6	-0.6
Fractured/broken bones in last 5 years	3.2	4.1	8.0	-2.0	-2.8	-1.8	1.6	-2.2	-1.4
Age started oral contraceptive pill	0.0	0.0	0.1	0.1	0.1	0.3	-0.2	0.2	0.1
Diastolic blood pressure, automated reading	0.1	0.2	0.3	0.5	0.6	-0.1	-0.5	-0.4	0.6
Ever depressed for a whole week	0.3	0.4	0.8	-0.7	-0.9	-0.4	0.6	-0.3	-0.5
Unable to work because of sickness or disability	0.2	0.3	0.8	0.6	0.9	0.2	-0.4	0.6	0.3
Commuting to job workplace: Cycle	0.2	0.2	0.4	0.4	0.5	0.1	-0.6	0.4	0.7
Myopia	1.6	2.3	3.2	1.4	1.3	1.8	-1.4	1.8	1.3
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	-0.1	-0.4	0.3	0.3	-0.1	-0.4
Cholesterol lowering medication	0.1	0.2	0.5	0.3	0.4	0.1	-0.5	-0.0	0.7
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	-0.3	-0.1	-0.6	0.2	-0.3	0.0
Pain experienced in last month	1.1	1.9	2.9	1.1	0.7	1.7	-1.6	1.3	1.6
Supplements: Calcium	0.7	0.8	1.5	0.9	0.4	0.9	-1.1	0.5	1.2
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	-0.1	0.6	-0.6	0.4	0.3	-0.5
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	-0.3	0.1	-0.2	0.1	-0.1	0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.7	-0.2	0.0	-0.9	0.6	-0.7	-0.6
Heart disease (siblings)	0.1	0.1	0.2	-0.1	0.3	-0.4	0.2	-0.4	-0.0
Alcohol drinker status: Previous	4.5	5.2	7.3	-1.9	-1.9	-2.6	2.3	-2.7	-2.1
Pack years of smoking	0.5	0.8	1.2	1.0	0.8	0.8	-0.8	1.1	0.8
Impedance of whole body	0.0	0.2	0.4	-0.5	-0.3	-0.1	0.6	-0.1	-0.6
Leg fat mass (left)	0.2	0.7	1.1	1.0	0.9	1.0	-0.9	0.3	0.8
Arm predicted mass (left)	0.2	1.1	2.0	-0.8	-1.1	-0.8	1.0	-1.4	-1.1