[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr1:5,611,729-7,460,433

Best TWAS P=1.13e-22 · Best GWAS P=4.87e-22 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	THAP3	0.05	0.04	blup	51	0.05	4.4e-06	-9.01	9.8	1.1e-22	-0.97	0.01	0.99	TRUE
1	CommonMind	Brain Pre-frontal Cortex	DNAJC11	0.03	0.03	lasso	5	0.04	3.1e-05	6.95	8.9	6.5e-19	-0.80	0.03	0.95	FALSE
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	DNAJC11	0.02	0.00	blup	74	0.01	9.1e-03	6.96	8.6	7.9e-18	-0.74	0.03	0.60	FALSE
19	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	THAP3	0.08	0.04	enet	7	0.04	3.7e-03	-9.30	8.5	1.9e-17	-0.90	0.01	0.91	FALSE
11	GTEx	Testis	THAP3	0.22	0.19	lasso	5	0.22	3.1e-10	6.96	8.5	2.6e-17	-0.73	0.28	0.72	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PLEKHG5	0.09	0.06	enet	28	0.05	3.1e-07	5.63	8.3	6.6e-17	-0.60	0.46	0.54	FALSE
8	GTEx	Heart Left Ventricle	THAP3	0.12	0.07	lasso	7	0.09	1.9e-05	-8.51	8.3	1.0e-16	-0.91	0.04	0.95	FALSE
15	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	THAP3	0.06	0.02	blup	51	0.03	2.8e-04	-9.01	7.3	2.8e-13	-0.86	0.02	0.94	FALSE
3	GTEx	Breast Mammary Tissue	GPR153	0.13	0.03	lasso	5	0.01	1.3e-01	6.96	-7.0	2.0e-12	0.50	0.12	0.10	FALSE
5	GTEx	Breast Mammary Tissue (Female)	GPR153	0.07	-0.01	enet	3	0.00	4.3e-01	6.96	-6.9	5.6e-12	0.51	0.04	0.08	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	NOL9	0.08	0.00	blup	44	0.01	4.9e-02	4.03	6.8	1.2e-11	-0.48	0.01	0.22	FALSE
9	GTEx	Muscle Skeletal	THAP3	0.14	0.10	lasso	8	0.14	2.4e-13	2.56	6.6	4.6e-11	-0.81	0.08	0.92	FALSE
21	The Cancer Genome Atlas	Testicular Germ Cell Tumors	KLHL21	0.11	0.12	lasso	2	0.09	5.4e-04	6.57	6.6	5.0e-11	-0.49	0.24	0.30	FALSE
6	GTEx	Cells Transformed fibroblasts	THAP3	0.19	0.11	lasso	5	0.17	1.2e-12	2.47	6.5	1.1e-10	-0.79	0.23	0.77	FALSE
4	GTEx	Breast Mammary Tissue (Female)	THAP3	0.10	0.03	lasso	2	0.02	6.8e-02	6.96	-6.4	1.2e-10	0.49	0.07	0.06	FALSE
12	ROSMAP	Brain Pre-frontal Cortex	KLHL21	0.04	0.03	lasso	3	0.02	7.8e-04	6.21	-6.2	5.4e-10	0.48	0.73	0.03	FALSE
22	The Cancer Genome Atlas	Thyroid Carcinoma	THAP3	0.06	0.03	lasso	4	0.05	1.1e-05	2.47	6.2	7.0e-10	-0.77	0.09	0.88	FALSE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	THAP3	0.04	0.04	blup	52	0.05	4.5e-10	2.52	5.7	1.5e-08	-0.73	0.70	0.30	FALSE
16	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	THAP3	0.10	0.07	blup	51	0.08	4.0e-05	0.41	5.5	2.8e-08	-0.69	0.06	0.74	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	PLEKHG5	0.09	0.10	enet	6	0.10	8.2e-13	5.63	5.4	6.7e-08	-0.38	1.00	0.00	FALSE
10	GTEx	Skin Sun Exposed Lower leg	THAP3	0.13	0.12	lasso	5	0.10	7.5e-09	2.52	5.3	8.9e-08	-0.70	0.52	0.48	FALSE
7	GTEx	Cells Transformed fibroblasts	ZBTB48	0.17	0.06	enet	31	0.11	1.7e-08	4.59	5.2	2.2e-07	-0.44	0.03	0.95	FALSE