Best TWAS P=1.16e-11 · Best GWAS P=5.06e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CENPW | 0.04 | 0.06 | lasso | 10 | 0.06 | 2.4e-07 | -6.9 | 6.8 | 1.2e-11 | -0.99 | 0.02 | 0.98 | TRUE |
| 2 | GTEx | Heart Atrial Appendage | CENPW | 0.17 | 0.01 | enet | 15 | 0.06 | 1.8e-03 | -6.7 | 5.8 | 8.3e-09 | -0.70 | 0.03 | 0.56 | FALSE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CENPW | 0.04 | 0.05 | lasso | 5 | 0.05 | 2.6e-06 | -6.9 | 6.2 | 7.5e-10 | -0.98 | 0.02 | 0.98 | FALSE |
| 4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CENPW | 0.04 | 0.06 | blup | 35 | 0.05 | 9.2e-07 | -6.7 | 6.1 | 1.1e-09 | -0.98 | 0.02 | 0.98 | FALSE |