TWAS
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Models
Genes
Traits
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Traits
:
Lung FEV1/FVC ratio
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chr6:125,970,401-127,355,237
Best TWAS P=1.16e-11 · Best GWAS P=5.06e-12 conditioned to 1
126M
126.2M
126.4M
126.6M
126.8M
127M
127.2M
127.4M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
CommonMind
Brain Pre-frontal Cortex
CENPW
0.04
0.06
lasso
10
0.06
2.4e-07
-6.9
6.8
1.2e-11
-0.99
0.02
0.98
TRUE
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
CENPW
0.04
0.05
lasso
5
0.05
2.6e-06
-6.9
6.2
7.5e-10
-0.98
0.02
0.98
FALSE
4
The Cancer Genome Atlas
Brain Lower Grade Glioma
CENPW
0.04
0.06
blup
35
0.05
9.2e-07
-6.7
6.1
1.1e-09
-0.98
0.02
0.98
FALSE
2
GTEx
Heart Atrial Appendage
CENPW
0.17
0.01
enet
15
0.06
1.8e-03
-6.7
5.8
8.3e-09
-0.70
0.03
0.56
FALSE