TWAS
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Usage
Models
Genes
Traits
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Traits
:
Lung FEV1/FVC ratio
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chr7:129,342,404-130,839,735
Best TWAS P=2.6e-08 · Best GWAS P=1.71e-08 conditioned to 0.0344
129.4M
129.6M
129.8M
130M
130.2M
130.4M
130.6M
130.8M
0
2
4
6
8
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Brain Cerebellum
CEP41
0.24
0.13
enet
20
0.13
0.00015
-5.6
-5.6
2.6e-08
0.77
0.01
0.96
TRUE
1
GTEx
Adipose Subcutaneous
MEST
0.10
0.02
lasso
4
0.01
0.02030
4.8
5.5
4.8e-08
-0.59
0.02
0.91
FALSE
3
GTEx
Cells Transformed fibroblasts
MEST
0.14
0.01
enet
56
0.04
0.00039
4.2
5.4
8.2e-08
-0.26
0.37
0.32
FALSE