Best TWAS P=5.26e-08 · Best GWAS P=5.95e-08 conditioned to 0.35
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ROSMAP | Brain Pre-frontal Cortex | LEPROTL1 | 0.05 | 0.04 | enet | 6 | 0.04 | 8.3e-06 | 5.4 | 5.3 | 1.2e-07 | 0.92 | 0.00 | 0.99 | FALSE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | TMEM66 | 0.10 | 0.10 | lasso | 8 | 0.09 | 3.0e-11 | 5.4 | -5.4 | 5.3e-08 | -0.96 | 0.00 | 1.00 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MBOAT4 | 0.06 | 0.02 | blup | 38 | 0.04 | 5.1e-08 | 4.7 | 5.3 | 1.5e-07 | 0.87 | 0.03 | 0.97 | FALSE |
| 4 | The Cancer Genome Atlas | Glioblastoma Multiforme | MBOAT4 | 0.09 | 0.04 | lasso | 3 | 0.02 | 9.7e-02 | 5.1 | 5.2 | 2.5e-07 | 0.94 | 0.01 | 0.75 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MBOAT4 | 0.08 | 0.05 | lasso | 3 | 0.06 | 4.3e-07 | 5.4 | 5.4 | 6.1e-08 | 0.98 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | MBOAT4 | 0.09 | 0.00 | blup | 38 | 0.02 | 2.2e-02 | 4.2 | 5.3 | 1.1e-07 | 0.87 | 0.02 | 0.68 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | MBOAT4 | 0.04 | 0.03 | blup | 38 | 0.03 | 1.4e-04 | 5.4 | 5.4 | 8.1e-08 | 0.97 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MBOAT4 | 0.06 | 0.02 | blup | 38 | 0.05 | 1.0e-05 | 5.1 | 5.3 | 1.3e-07 | 0.94 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | LEPROTL1 | 0.03 | 0.04 | lasso | 4 | 0.03 | 4.7e-04 | 5.4 | 5.2 | 1.8e-07 | 0.97 | 0.00 | 0.95 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | MBOAT4 | 0.07 | 0.02 | blup | 38 | 0.05 | 1.2e-05 | 5.1 | 5.4 | 5.3e-08 | 0.94 | 0.01 | 0.99 | TRUE |