[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr8:21,758,119-23,240,950

Best TWAS P=3.76e-09 · Best GWAS P=5e-09 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous BIN3 0.11 0.10 enet 11 0.10 1.4e-08 5.0 5.1 3.0e-07 0.79 0.16 0.84 FALSE
2 GTEx Adipose Subcutaneous C8orf58 0.09 0.03 lasso 3 0.01 6.2e-02 5.6 5.7 1.2e-08 0.87 0.03 0.94 FALSE
3 GTEx Breast Mammary Tissue (Male) BIN3 0.22 0.00 lasso 4 -0.01 6.5e-01 5.7 5.2 2.3e-07 0.86 0.03 0.64 FALSE
4 GTEx Breast Mammary Tissue (Female) BIN3 0.03 0.00 lasso 2 0.02 7.6e-02 5.4 5.2 1.7e-07 0.84 0.04 0.26 FALSE
5 GTEx Esophagus Mucosa BIN3 0.13 0.09 lasso 3 0.10 5.4e-07 5.1 5.3 1.1e-07 0.90 0.03 0.97 FALSE
6 GTEx Lung CCAR2 0.11 0.07 enet 11 0.08 2.0e-06 5.4 5.5 3.3e-08 0.94 0.02 0.98 FALSE
7 GTEx Ovary BIN3 0.38 0.24 lasso 5 0.30 4.0e-08 5.6 5.3 1.2e-07 0.82 0.03 0.96 FALSE
8 GTEx Skin Not Sun Exposed Suprapubic BIN3 0.09 0.09 lasso 2 0.08 2.5e-05 5.7 5.7 1.5e-08 0.92 0.02 0.98 FALSE
9 GTEx Skin Not Sun Exposed Suprapubic CCAR2 0.11 0.08 lasso 4 0.05 8.8e-04 5.6 5.5 3.9e-08 0.92 0.02 0.98 FALSE
10 GTEx Whole Blood C8orf58 0.05 0.03 lasso 4 0.02 5.5e-03 5.4 5.2 1.7e-07 0.90 0.02 0.92 FALSE
11 METSIM Adipose C8orf58 0.04 0.02 enet 13 0.02 1.1e-03 4.7 5.2 2.5e-07 0.80 0.14 0.85 FALSE
12 ROSMAP Brain Pre-frontal Cortex CTD-3247F14.2 0.10 0.12 lasso 3 0.12 1.5e-14 5.6 5.8 8.2e-09 0.92 0.01 0.99 FALSE
13 YFS Blood KIAA1967 0.05 0.04 bslmm 505 0.04 2.4e-12 5.8 5.2 2.3e-07 0.86 0.00 1.00 FALSE
14 The Cancer Genome Atlas Lung Adenocarcinoma BIN3 0.04 0.03 lasso 4 0.04 3.6e-05 5.8 5.9 3.8e-09 0.99 0.00 0.99 TRUE