[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr8:21,758,119-23,240,950

Best TWAS P=3.76e-09 · Best GWAS P=5e-09 conditioned to 1

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
14	The Cancer Genome Atlas	Lung Adenocarcinoma	BIN3	0.04	0.03	lasso	4	0.04	3.6e-05	5.8	5.9	3.8e-09	0.99	0.00	0.99	TRUE
12	ROSMAP	Brain Pre-frontal Cortex	CTD-3247F14.2	0.10	0.12	lasso	3	0.12	1.5e-14	5.6	5.8	8.2e-09	0.92	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	C8orf58	0.09	0.03	lasso	3	0.01	6.2e-02	5.6	5.7	1.2e-08	0.87	0.03	0.94	FALSE
8	GTEx	Skin Not Sun Exposed Suprapubic	BIN3	0.09	0.09	lasso	2	0.08	2.5e-05	5.7	5.7	1.5e-08	0.92	0.02	0.98	FALSE
6	GTEx	Lung	CCAR2	0.11	0.07	enet	11	0.08	2.0e-06	5.4	5.5	3.3e-08	0.94	0.02	0.98	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	CCAR2	0.11	0.08	lasso	4	0.05	8.8e-04	5.6	5.5	3.9e-08	0.92	0.02	0.98	FALSE
5	GTEx	Esophagus Mucosa	BIN3	0.13	0.09	lasso	3	0.10	5.4e-07	5.1	5.3	1.1e-07	0.90	0.03	0.97	FALSE
7	GTEx	Ovary	BIN3	0.38	0.24	lasso	5	0.30	4.0e-08	5.6	5.3	1.2e-07	0.82	0.03	0.96	FALSE
4	GTEx	Breast Mammary Tissue (Female)	BIN3	0.03	0.00	lasso	2	0.02	7.6e-02	5.4	5.2	1.7e-07	0.84	0.04	0.26	FALSE
10	GTEx	Whole Blood	C8orf58	0.05	0.03	lasso	4	0.02	5.5e-03	5.4	5.2	1.7e-07	0.90	0.02	0.92	FALSE
3	GTEx	Breast Mammary Tissue (Male)	BIN3	0.22	0.00	lasso	4	-0.01	6.5e-01	5.7	5.2	2.3e-07	0.86	0.03	0.64	FALSE
13	YFS	Blood	KIAA1967	0.05	0.04	bslmm	505	0.04	2.4e-12	5.8	5.2	2.3e-07	0.86	0.00	1.00	FALSE
11	METSIM	Adipose	C8orf58	0.04	0.02	enet	13	0.02	1.1e-03	4.7	5.2	2.5e-07	0.80	0.14	0.85	FALSE
1	GTEx	Adipose Subcutaneous	BIN3	0.11	0.10	enet	11	0.10	1.4e-08	5.0	5.1	3.0e-07	0.79	0.16	0.84	FALSE